Straight guide type medicine feeding device

Abstract

The invention relates to a straight guide type medicine feeding device which is formed by connecting a balloon and a handle seat through a pushing tube, the balloon is of a double-layer structure composed of an attachment bag and an inner bag, protrusions are arranged on the outer surface of the attachment bag at intervals in the radial direction, and the inner bag is arranged in the attachment bag. The protrusions are arranged on the surface of the balloon in the radial direction, in the balloon dilatation process, safe dilatation of blood vessels can be effectively guaranteed through gaps between the radial protrusions, and the risk of blood vessel dilatation tearing is greatly reduced; a syringe connected with the handle end directly guides medicine to an affected part through a medicine feeding hole in the top end of the protrusion on the surface of the balloon to be released, blood can normally pass through a blood circulation groove formed by gaps of the protrusion while the medicine is released, the problem of local tissue necrosis or tissue intolerance caused by blood cutoff is avoided, and the safety of a patient is improved. In addition, no medicine participates and is lost in the whole conveying process, the surgical operation difficulty of an operator is reduced, and the treatment effect is improved.

Description

Technical Field

[0001] The present invention relates to an intravascular drug delivery device, and particularly to a direct guiding drug delivery device, belonging to the technical field of medical devices. Background Art

[0002] With the development of social economy, the national lifestyle has undergone profound changes. Especially with the acceleration of population aging and urbanization, the epidemic trend of cardiovascular risk factors in China shows an obvious upward trend, resulting in a continuous increase in the number of cardiovascular disease patients. In the next 10 years, the number of cardiovascular disease patients will still grow rapidly.

[0003] Currently, cardiovascular disease deaths rank first among the total causes of death of urban and rural residents, accounting for 44.8% in rural areas and 41.9% in urban areas. Moreover, thrombosis shows a trend of getting younger, having an increasing impact on human health. Rapid recanalization of complex calcified lesions is an essential means for treating patients and a prerequisite for subsequent treatment of interventional surgery. Ensuring the patency of the human circulation during the process of opening or establishing a cavity is a necessary condition for maintaining the normal operation of the diseased organ and its upstream and downstream organs. During the treatment of stenosis in the heart, brain, and peripheral blood vessels, drugs are usually delivered by spraying them on the surface of the balloon. The operator has to first reach the lesion site with treatment instruments through a guiding catheter, an intermediate catheter, a microcatheter, etc. This process is very difficult, involving a large number of instrument passing-through and retraction processes, which is time-consuming. The drug coating is prone to falling off, affecting the treatment effect. Moreover, when the drug balloon expands and delivers drugs, it will block blood flow, causing clinical problems that patients cannot tolerate. Therefore, it is extremely urgent to design a product that can directly deliver drugs to the lesion site without blocking blood flow. Summary of the Invention

[0004] To solve the above technical problems, the present invention proposes a direct guiding drug delivery device, and its technical solution is as follows: A direct guiding drug delivery device is composed of a balloon connected to a handle base through a push tube. The balloon is a double-layer structure composed of an attachment sac and an inner sac. The outer surface of the attachment sac is radially and spacedly provided with protrusions, and the inner sac is arranged inside the attachment sac.

[0005] Further, the push tube is a tubular double-chamber structure, and a double-chamber channel is axially formed inside.

[0006] Further, the handle base includes an inner sac handle base and an attachment sac handle base. The inner sac handle base is axially arranged at the proximal end of the push tube, and the attachment sac handle base is radially arranged on the proximal end of the push tube.

[0007] Further, the attachment sac and the inner sac are respectively communicated with the attachment sac handle base and the inner sac handle base through the double-chamber channel of the push tube.

[0008] Further, a radiopaque ring is circumferentially arranged at the distal end of the attachment sac.

[0009] Furthermore, the attachment balloon is a compliant balloon and can fit according to the blood vessel morphology.

[0010] Furthermore, the inner balloon is a non-compliant balloon and can provide sufficient support for the attachment balloon.

[0011] Furthermore, the heights of the protrusions are the same, and the spacing is 0.1 mm to 0.6 mm.

[0012] Furthermore, a medicine delivery hole is provided at the top end of the protrusion, and the medicine can directly reach the lesion site.

[0013] Furthermore, medicine delivery holes are provided on the surface of the attachment balloon, and the diameter is 0.05 mm to 0.9 mm.

[0014] Furthermore, for the direct guiding medicine delivery device, the whole system reaches the lesion site through a loach guide wire, a micro guide wire or a nerve guide wire at the corresponding application position.

[0015] Compared with the prior art, the beneficial effects of the present invention are as follows: Radial protrusions are provided on the surface of the balloon. During the balloon dilation process, the gaps between the radial protrusions can effectively ensure the safe dilation of the blood vessel, greatly reducing the risk of blood vessel dilation and tearing; the syringe connected to the handle end releases the medicine directly to the affected area through the medicine delivery holes at the top ends of the protrusions on the balloon surface. While the medicine is being released, blood can normally pass through the blood flow channels formed by the protrusion gaps, enabling the blood to pass through normally and avoiding problems such as local tissue necrosis or tissue intolerance caused by blood flow interruption. At the same time, the outer diameter and flexibility of the present invention are consistent with those of the guiding catheter, intermediate catheter and micro catheter used clinically. Therefore, its ability to pass through the lesion is much greater than that of any corresponding dilation balloon, drug balloon and thrombectomy device at the same position. During the operation, the operator does not need to use other instruments to dilate the lesion blood vessel or deliver medicine. The treatment of the affected area is carried out while establishing the blood vessel access. There is no participation and loss of medicine during the delivery process, reducing the surgical operation difficulty of the operator and improving the treatment effect. Description of the Drawings

[0016] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the following drawings are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings.

[0017] Figure 1 It is a schematic diagram of the overall structure of the direct guiding medicine delivery device; Figure 2 It is a schematic diagram of the cluster balloon structure; Figure 3Schematic diagram of a double-lumen channel structure; In the figure: 1. Attachment sac, 2. Inner sac, 3. Drug delivery hole, 4. Imaging ring, 5. Pushing tube, 6. Inner sac handle seat, 7. Attachment sac handle seat, 8. Double-lumen channel. Embodiment

[0018] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention. Embodiment

[0019] As Figure 1 shown, a direct guiding drug delivery device is composed of a pushing tube 5, an attachment sac 1, an inner sac 2, a drug delivery hole 3, an imaging ring 4, an inner sac handle seat 6 and an attachment sac handle seat 7. The pushing tube 5 is woven from metal or non-metal wires and is composed of a composite of an inner layer of PTFE material and an outer layer of polymer material. The pushing tube 5 is a tubular double-lumen structure, and a double-lumen channel 8 is axially formed inside. The attachment sac 1 and the inner sac 2 are respectively communicated with the attachment sac handle seat 7 and the inner sac handle seat 6 through the double-lumen channel 8 of the pushing tube 5 to form a direct guiding drug delivery device; the outer surface of the attachment sac 1 is radially provided with protrusions at intervals, the inner sac 2 is arranged inside the attachment sac 1, and the drug delivery hole 3 is arranged at the top of the protrusion, and the drug can directly reach the lesion position. Embodiment

[0020] A direct guiding drug delivery device has the common attributes of a catheter and a balloon, and can make both the catheter and the balloon reach the lesion position through a one-time pushing operation. When in use, the device is advanced along a guide wire or a micro-guide wire to the lesion position. The inner sac handle seat 6 is connected to a stamping device such as a pressure pump to expand the inner sac 2 to achieve the effect of expanding blood vessels; then a syringe filled with a therapeutic drug is connected to the attachment sac handle seat 7, and the syringe is pushed to administer the drug according to the treatment requirements. The drug directly reaches the lesion to be treated from the drug delivery hole 3, and during the whole treatment process, the blood vessel will not be blocked, and the blood flow can pass normally, avoiding clinical problems such as hypoxia of distal tissues caused by blood stasis or patient intolerance. Embodiment

[0021] The imaging ring 4 is arranged at the distal end of the attachment sac and is wrapped by a polymer material, which will not damage the blood vessel and can indicate the position reached by the system. Embodiment

[0022] The length of the attachment sac 1 is 5 mm to 120 mm, which is suitable for peripheral blood vessels, coronary blood vessels and intracranial blood vessels. Embodiment

[0023] The material of the push tube is at least one of polyether block amide, polyamide, polytetrafluoroethylene, polyurethane, stainless steel, and nitinol.

[0024] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. A direct-conducting drug delivery device, which is composed of a balloon connected to a handle base through a push tube, is characterized in that, The balloon is a double-layer structure composed of an attachment balloon (1) and an inner balloon (2). The outer surface of the attachment balloon (1) is radially provided with protrusions at intervals, and the inner balloon (2) is arranged inside the attachment balloon (1).

2. The direct-conducting medicine delivery device according to claim 1, characterized in that, The push tube (5) is a tubular double-chamber structure, and a double-chamber channel (8) is axially formed inside it.

3. The direct guiding type medicine delivery device according to claim 1, characterized in that, The handle seat includes an inner balloon handle seat (6) and an attachment balloon handle seat (7). The inner balloon handle seat (6) is axially arranged at the proximal end of the push tube (5), and the attachment balloon handle seat (7) is radially arranged on the proximal end of the push tube (5).

4. A direct guiding drug delivery device according to any one of claims 1-3, characterized in that, The attachment balloon (1) and the inner balloon (2) are respectively communicated with the attachment balloon handle seat (7) and the inner balloon handle seat (6) through the double-chamber channel (8) of the push tube (5).

5. A direct guiding drug delivery device according to any one of claims 1, characterized in that A developing ring (4) is circumferentially arranged at the distal end of the attachment balloon (1).

6. The direct-conducting medicine delivery device according to any one of claims 1, wherein The attachment balloon (1) is a compliant balloon.

7. A direct guiding drug delivery device according to any one of claims 1, characterized in that, The inner balloon (2) is a non-compliant balloon.

8. A direct guiding drug delivery device according to any one of claims 1, characterized in that The heights of the protrusions are the same.

9. A direct guiding drug delivery device according to any one of claims 1, characterized in that, A drug delivery hole (3) is arranged at the top of the protrusion.

10. A direct guiding drug delivery device according to any one of claims 1, characterized in that, Drug delivery holes (3) are arranged on the surface of the attachment balloon (1).

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