A probiotic and prebiotic composition and methods of preparation, uses thereof

By combining probiotics with multiple strains and optimizing the combination of prebiotics, the problems of unreasonable strain selection and process defects in existing probiotic compositions have been solved, achieving effective relief of intestinal flora imbalance caused by antibiotics and enhancement of immune function.

CN120285023BActive Publication Date: 2026-07-07LUNAN BETTER PHARMA
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Patent Information

Application Number
CN202510443414.X
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-04-10
Publication Date
2026-07-07
Estimated Expiration
2045-04-10

AI Technical Summary

Technical Problem

Current probiotic compositions suffer from problems such as unreasonable strain selection and ratio, single prebiotic combination, lack of synergistic components, low viability due to process defects, and lack of clinical suitability, which cannot effectively alleviate intestinal flora imbalance and related symptoms caused by antibiotics.

Method used

A multi-strain synergistic probiotic composition is employed, including Bifidobacterium animalis subsp. lactis BLa80, Pediococcus lactis CCFM7902, Lactobacillus acidophilus LA85, Lactobacillus plantarum N13, Lactobacillus paracasei LC86, Bifidobacterium bifidum BBi32, Lactobacillus rhamnosus LRa05, and Lactobacillus casei LC89, combined with resistant dextrin, xylooligosaccharides, fructooligosaccharides, stachyose, erythritol, and vitamin C. By optimizing the granulation process of the binder erythritol, the stability and functionality of the probiotic composition are ensured.

Benefits of technology

It significantly improves antibiotic-induced gut microbiota dysbiosis, relieves diarrhea and constipation, enhances immune function, reduces antibiotic-related inflammatory responses, increases gut microbiota diversity, and provides precise intervention for antibiotic adjuvants.

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Abstract

This invention belongs to the food or pharmaceutical field, specifically relating to a probiotic and prebiotic composition, its preparation process, and its application. The composition includes probiotics, resistant dextrin, xylooligosaccharides, fructooligosaccharides, stachyose, erythritol, and cranberry powder, prepared using a fluidized bed spray granulation process. As an adjuvant to antibiotics, this composition has been verified in animal and clinical trials to synergistically treat upper / lower respiratory tract infections and urinary tract infections, shorten symptom duration, accelerate recovery from the primary disease, maintain intestinal flora diversity, increase the abundance of beneficial bacteria such as Bifidobacteria, reduce the incidence of adverse reactions, and alleviate antibiotic-associated diarrhea. This invention provides a microecological restoration solution for antibiotic treatment, possessing clear clinical value and technological feasibility.
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