External medicinal liquor formula for treating arthralgia and myalgia

Abstract

The invention relates to the field of medicinal liquor, in particular to an external medicinal liquor formula for treating arthralgia and myalgia. Comprising the following components: folium artemisiae argyi, ramulus mori, folium mori, cassia twig, ephedra, lycopodium clavatum, notopterygium root, radix angelicae pubescentis, fennel seed, cucumber seed, lettuce seed, galangal, parasitic loranthus, cyathula officinalis, rhizoma drynariae, fructus psoraleae, beautiful sweetgum fruit, datura stramonium, red ginseng, astragalus membranaceus, liquorice, moxibustion semen strychni, moxibustion radix aconiti carmichaeli, moxibustion tripterygium wilfordii core, borneol, water-soluble azone, salvia miltiorrhiza and 60-degree white spirit. The multi-dimensional treatment of arthralgia and myalgia is realized on the premise of ensuring the safety by means of processing attenuation, transdermal controlled release, multi-component synergy and the like.

Description

Technical Field

[0001] The present invention relates to the field of medicinal wines, and particularly to an external medicinal wine formula for treating bone and muscle pain. Background Art

[0002] In the fields of traditional Chinese medicine and external medicinal wines, the treatment of bone and muscle pain has a long history. However, traditional external medicinal wines still have some limitations:

[0003] 1. Low transdermal absorption rate: Most medicinal wines rely on the permeation-promoting effect of alcohol itself. However, many active ingredients (such as alkaloids and saponins) are difficult to penetrate the skin barrier, resulting in limited efficacy.

[0004] 2. Insufficient toxicity control: Some formulas use highly toxic herbs such as raw Strychnos nux-vomica and raw Aconitum carmichaelii, and the processing technology is not standardized, posing potential safety hazards.

[0005] 3. Insufficient scientific compatibility: Some prescriptions are based solely on experience and lack modern pharmacological verification, which may lead to antagonism or toxicity superposition among some ingredients.

[0006] 4. Stability problems: It is prone to precipitation and oxidation during long-term storage, affecting the medicinal efficacy.

[0007] Existing external medicinal wines still have deficiencies in terms of safety, transdermal efficiency, and scientific compatibility. Summary of the Invention

[0008] In order to solve the above technical problems, the present invention provides an external medicinal wine formula for treating bone and muscle pain.

[0009] An external medicinal wine formula for treating bone and muscle pain, comprising the following ingredients: Folium Artemisiae Argyi, Ramulus Mori, Folium Mori, Ramulus Cinnamomi, Herba Ephedrae, Herba Lycopodii, Rhizoma seu Radix Notopterygii, Rhizoma seu Radix Angelicae Pubescentis, Fructus Foeniculi, Semen Cucurbitae, Semen Lactucae, Rhizoma Zingiberis Officinalis, Herba Taxilli, Caulis Spatholobi, Rhizoma Drynariae, Fructus Psoraleae, Fructus Liquidambaris, Datura stramonium, Radix Ginseng Rubra, Radix Astragali, Radix Glycyrrhizae, Semen Strychni Praeparatum, Radix Aconiti Lateralis Praeparata, Caulis Tripterygii Wilfordii Praeparata, Borneolum Syntheticum, Solubilized Azone, Radix Salviae Miltiorrhizae, and 60-degree Chinese liquor.

[0010] Further, it includes the following raw materials by weight: 10 - 500 g of Artemisia argyi, 10 - 150 g of Ramulus Mori, 10 - 100 g of Folium Mori, 10 - 150 g of Ramulus Cinnamomi, 10 - 100 g of Ephedra sinica, 10 - 200 g of Lycopodium clavatum, 10 - 100 g of Notopterygium incisum, 10 - 150 g of Angelica pubescens, 10 - 200 g of Fructus Foeniculi, 10 - 80 g of Cucumber Seeds, 10 - 80 g of Lettuce Seeds, 10 - 60 g of Galangal, 10 - 150 g of Taxillus chinensis, 10 - 200 g of Cyathula officinalis Kuan, 10 - 200 g of Drynaria fortunei, 10 - 150 g of Psoralea corylifolia, 10 - 200 g of Clerodendrum trichotomum Thunb., 50 - 200 g of Datura stramonium, 10 - 500 g of Red Ginseng, 10 - 1000 g of Astragalus membranaceus, 10 - 150 g of Glycyrrhiza uralensis Fisch., 50 - 150 g of Borneol, 10 - 200 g of Salvia miltiorrhiza, 40 - 80 g of Stir-fried Strychnos nux-vomica, 100 - 200 g of Stir-fried Aconitum carmichaelii Debx., 40 - 150 g of Stir-fried Tripterygium wilfordii Hook.f. heart, and 100 - 120 jin of 60-degree Baijiu;

[0011] The water-soluble azone is added in a proportion of 500 - 1500 ml per 100 jin of medicinal liquor.

[0012] Further, the method for making the medicinal liquor includes the following steps:

[0013] S1. Weigh the raw materials and add them to a wine-making container. The raw materials include Artemisia argyi, Ramulus Mori, Folium Mori, Ramulus Cinnamomi, Ephedra sinica, Lycopodium clavatum, Notopterygium incisum, Angelica pubescens, Fructus Foeniculi, Cucumber Seeds, Lettuce Seeds, Galangal, Taxillus chinensis, Cyathula officinalis Kuan, Drynaria fortunei, Psoralea corylifolia, Clerodendrum trichotomum Thunb., Datura stramonium, Red Ginseng, Astragalus membranaceus, Glycyrrhiza uralensis Fisch., Stir-fried Strychnos nux-vomica, Stir-fried Aconitum carmichaelii Debx., Stir-fried Tripterygium wilfordii Hook.f. heart, and Borneol. Among them, Stir-fried Strychnos nux-vomica, Stir-fried Aconitum carmichaelii Debx., and Stir-fried Tripterygium wilfordii Hook.f. heart need to be processed by roasting. Strychnos nux-vomica is stir-fried until it bulges, Aconitum carmichaelii Debx. is stir-fried until it cracks, and part of Tripterygium wilfordii Hook.f. heart is stir-fried until slightly yellow and black;

[0014] S2. Pour 60-degree Baijiu into the wine-making container and soak for 10 - 30 days. During the soaking period, set the stirring time for stirring operation;

[0015] S3. Filter the mixed liquor processed in step S2 to remove the dregs;

[0016] S4. Add Borneol and azone to the liquor filtered in S3 and stir.

[0017] The compatibility of Notopterygium incisum, Angelica pubescens, Ramulus Cinnamomi, Ephedra sinica, etc. can relieve wind-cold-damp arthralgia, which is in line with traditional Chinese medicine theory.

[0018] Salvia miltiorrhiza, Cyathula officinalis Kuan, Clerodendrum trichotomum Thunb., etc. can promote local blood circulation and may improve pain and stiffness.

[0019] Drynaria fortunei, Psoralea corylifolia, Taxillus chinensis, etc. are targeted at chronic strain and are suitable for senile degenerative diseases.

[0020] Datura stramonium and Strychnos nux-vomica (which need to be processed) contain alkaloids and may take effect by blocking pain conduction, but the dosage needs to be strictly controlled.

[0021] The Chinese medicine "moxibustion" in this prescription is a highly toxic Chinese medicine. After processing by sand roasting, its toxicity can be greatly reduced to ensure the safety of patients' medication.

[0022] Both azone and borneol are transdermal agents, which can enable the medicinal liquor to quickly penetrate the skin barrier, directly enter the capillaries (meridians), and participate in blood circulation to achieve the purpose of treating diseases.

[0023] Compared with the prior art, the present invention has the following advantages: The present invention embodies the design concept of "slow release of powerful drugs". Through methods such as reducing toxicity by processing, transdermal controlled release, and multi-component synergy, multi-dimensional treatment of bone and muscle pain is achieved on the premise of ensuring safety;

[0024] Multi-target synergistic effect. The wind-expelling and dampness-removing group (Notopterygium incisum, Angelica pubescens, Cinnamomum cassia, etc.) and the promoting blood circulation and removing stasis group (Salvia miltiorrhiza, Cyathula officinalis, etc.) form a synergy, which conforms to the traditional Chinese medicine principle of "treating wind first by treating blood";

[0025] The liver and kidney tonifying group (Drynaria fortunei, Taxillus chinensis, etc.) and the pain relieving group (Datura stramonium, Strychnos nux-vomica, etc.) take both the root cause and symptoms into consideration, and are suitable for the process of reducing toxicity and enhancing efficacy for chronic strain;

[0026] Process Strychnos nux-vomica (the strychnine content is reduced by 40 - 60%), Aconitum carmichaeli (the conversion rate of aconitine > 90%), and Tripterygium wilfordii Hook. f. After processing the heart part, the toxic component triptolide is reduced by more than 50% by using the sand roasting method;

[0027] Adopt transdermal technology. Water-soluble azone (concentration of 1 - 3%) can disorder the lipid arrangement of the stratum corneum of the skin, and the transdermal absorption rate is increased by 5 - 8 times;

[0028] Borneol has a dual effect. It not only promotes penetration (increasing absorption by 3 times), but also guides the medicinal effect to penetrate into deep tissues

[0029] Safety control. Limit 60-degree white liquor as the solvent, which can not only ensure the dissolution of active ingredients (alkaloid extraction rate > 85%), but also inhibit the growth of microorganisms;

[0030] The present invention improves the curative effect while ensuring safety through standardized processing, optimized transdermal technology, and scientific formula, and is applicable to modern clinical needs. Detailed implementation mode

[0031] The detailed implementation mode of the present invention

[0032] Example

[0033] A method for making an external medicinal liquor for treating bone and muscle pain, comprising the following steps:

[0034] S1. Weigh 250 g of Artemisia argyi leaves, 250 g of Mulberry twigs, 50 g of Mulberry leaves, 80 g of Cinnamon twigs, 50 g of Ephedra, 100 g of Lycopodium clavatum, 50 g of Notopterygium incisum, 80 g of Angelica pubescens, 100 g of Fennel seeds, 40 g of Cucumber seeds, 40 g of Lettuce seeds, 30 g of Galangal, 80 g of Taxillus chinensis, 100 g of Cyathula officinalis, 100 g of Drynaria fortunei, 80 g of Psoralea corylifolia, 100 g of Clerodendrum fortunatum, 130 g of Datura stramonium, 250 g of Red ginseng, 500 g of Astragalus membranaceus, 80 g of Licorice root, 100 g of Salvia miltiorrhiza, 60 g of Stir-fried Strychnos nux-vomica, 150 g of Stir-fried Aconite root, 100 g of Stir-fried Tripterygium wilfordii heart. Put the weighed raw materials into a wine-making container. Among them, Stir-fried Strychnos nux-vomica, Stir-fried Aconite root, and Stir-fried Tripterygium wilfordii heart need to be processed by stir-frying. Strychnos nux-vomica is stir-fried with sand until it swells, Aconite root is stir-fried with sand until it cracks, and part of Tripterygium wilfordii heart is stir-fried with sand until it turns slightly yellow and black.

[0035] S2. Pour 120 jin of 60-degree Baijiu (Chinese liquor) into the wine-making container and soak for 30 days. During the soaking period, stir once a day.

[0036] S3. Filter the mixed liquor processed in step S2 to remove the dregs.

[0037] S4. Add borneol and azone to the liquor filtered in S3 and stir. Add 100 g of borneol, and add azone in a proportion of 500 - 1500 ml per 100 jin of medicinal liquor.

[0038] Comparison between the present invention and traditional medicinal liquors

[0039] Index Traditional medicinal liquor The present invention Toxicity control Direct use of crude drugs, high risk Processing to reduce toxicity + dosage limit Transdermal efficiency Rely on alcohol for promoting penetration (absorption rate < 10%) Azone + borneol composite for promoting penetration (absorption rate > 50%) Scientific compatibility Empirical formula, may be antagonistic Multi-component synergy, in line with the principle of "treating wind first by treating blood" Stability Prone to precipitation and oxidation 60-degree white liquor for bacteriostasis, salvia miltiorrhiza for antioxidant

[0040] Clinical application of the present invention

[0041] The present invention is applicable to rheumatoid arthritis, lumbar disc herniation, chronic strain, etc., and has a better effect especially on cold-damp type pain (aggravated by cold). It is prohibited for those with skin damage, pregnant women, and those allergic to alcohol.

[0042] Usage method of the present invention

[0043] After external application, cooperate with hot compress (about 40 °C), which can further promote drug penetration. Apply 2 - 3 times a day, and the single dosage does not exceed 10 mL (to avoid skin irritation).

[0044] Safety monitoring

[0045] For the first use, a skin allergy test needs to be done (apply on the inner side of the wrist and observe for 24 hours). If skin redness, dizziness (possibly allergic to azone or toxic reaction) occur, stop using immediately and seek medical attention.

[0046] Through the "attenuation - enhanced penetration - multi - target" trinity design, the present invention solves the pain points of poor penetration and high toxicity of traditional medicinal wines. Its core technology lies in the combination of the processing technology and the transdermal technology, providing a feasible path for the modernization of external treatment of traditional Chinese medicine. It should be noted that the formula containing toxic medicinal materials must be used under the guidance of a doctor to avoid the risks caused by home - made preparations.

[0047] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. For those skilled in the art, the present invention can have various changes and modifications. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. An external medicinal liquor formula for treating pain in muscles and bones, characterized in that, It includes the following ingredients: Folium Artemisiae Argyi, Ramulus Mori, Folium Mori, Ramulus Cinnamomi, Herba Ephedrae, Herba Lycopodii, Rhizoma seu Radix Notopterygii, Radix Angelicae Pubescentis, Fructus Foeniculi, Semen Cucurbitae, Semen Lactucae Sativae, Rhizoma Zingiberis Officinalis, Herba Taxilli, Radix Cyathulae Officinalis, Rhizoma Drynariae, Fructus Psoraleae, Fructus Liquidambaris, Datura stramonium, Radix Ginseng Rubra, Radix Astragali, Radix Glycyrrhizae, Semen Strychni Praeparatum, Radix Aconiti Lateralis Praeparata, Caulis Tripterygii Wilfordii Praeparatus, Borneolum Syntheticum, Azone, Radix Salviae Miltiorrhizae and 60-degree Chinese liquor.

2. The external medicinal liquor formula for treating bone and muscle pain according to claim 1, characterized in that, It includes the following raw materials by weight: 10 - 500 g of Folium Artemisiae Argyi, 10 - 150 g of Ramulus Mori, 10 - 100 g of Folium Mori, 10 - 150 g of Ramulus Cinnamomi, 10 - 100 g of Herba Ephedrae, 10 - 200 g of Herba Lycopodii, 10 - 100 g of Rhizoma seu Radix Notopterygii, 10 - 150 g of Radix Angelicae Pubescentis, 10 - 200 g of Fructus Foeniculi, 10 - 80 g of Semen Cucurbitae, 10 - 80 g of Semen Lactucae Sativae, 10 - 60 g of Rhizoma Zingiberis Officinalis, 10 - 150 g of Herba Taxilli, 10 - 200 g of Radix Cyathulae Officinalis, 10 - 200 g of Rhizoma Drynariae, 10 - 150 g of Fructus Psoraleae, 10 - 200 g of Fructus Liquidambaris, 50 - 200 g of Datura stramonium, 10 - 500 g of Radix Ginseng Rubra, 10 - 1000 g of Radix Astragali, 10 - 150 g of Radix Glycyrrhizae, 50 - 150 g of Borneolum Syntheticum, 10 - 200 g of Radix Salviae Miltiorrhizae, 40 - 80 g of Semen Strychni Praeparatum, 100 - 200 g of Radix Aconiti Lateralis Praeparata, 40 - 150 g of Caulis Tripterygii Wilfordii Praeparatus, and 100 - 120 jin of 60-degree Chinese liquor; The azone is added in a proportion of 500 - 1500 ml per 100 jin of medicinal liquor.

3. The formula of an external medicinal liquor for treating bone and muscle pain according to claim 2, characterized in that, The method for making the medicinal liquor includes the following steps: S1. Weigh the raw materials and add them to a wine-making container. The raw materials include Folium Artemisiae Argyi, Ramulus Mori, Folium Mori, Ramulus Cinnamomi, Herba Ephedrae, Herba Lycopodii, Rhizoma seu Radix Notopterygii, Radix Angelicae Pubescentis, Fructus Foeniculi, Semen Cucurbitae, Semen Lactucae Sativae, Rhizoma Zingiberis Officinalis, Herba Taxilli, Radix Cyathulae Officinalis, Rhizoma Drynariae, Fructus Psoraleae, Fructus Liquidambaris, Datura stramonium, Radix Ginseng Rubra, Radix Astragali, Radix Glycyrrhizae, Semen Strychni Praeparatum, Radix Aconiti Lateralis Praeparata, Caulis Tripterygii Wilfordii Praeparatus and Borneolum Syntheticum. Among them, Semen Strychni Praeparatum, Radix Aconiti Lateralis Praeparata and Caulis Tripterygii Wilfordii Praeparatus need to be processed by roasting. Semen Strychni is stir-fried with sand until it swells, Radix Aconiti Lateralis is stir-fried with sand until it cracks, and part of Caulis Tripterygii Wilfordii is stir-fried with sand until it turns slightly yellow and black. S2. Pour 60-degree Chinese liquor into the wine-making container for soaking. The soaking time is controlled within 10 - 30 days. During the soaking period, set the stirring time for stirring operation. S3. Filter the mixed liquor obtained in step S2 to remove the dregs. S4. Add Borneolum Syntheticum and azone to the liquor filtered in S3 and stir.