Crisaborole Pickering emulsion as well as preparation method and application thereof

By preparing Pickering emulsion with Ceribro nanocrystals or polymer nanoparticles as emulsifiers, the problems of poor water solubility and skin permeability of Ceribro are solved, efficient transdermal delivery and stability are achieved, cost and skin irritation are reduced, and it is suitable for local treatment of atopic dermatitis.

CN120459029APending Publication Date: 2025-08-12CHINA PHARM UNIV
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Patent Information

Application Number
CN202510445749.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-04-10
Publication Date
2025-08-12

AI Technical Summary

Technical Problem

The poor water solubility of Ceribol leads to poor drug stability, poor skin permeability, high cost of use, and traditional preparations are highly irritating to the skin, affecting the patient's medication compliance and economic burden.

Method used

Pickering emulsions are prepared by using Ceribro nanocrystals or polymer nanoparticles as emulsifiers. A stable O/W Pickering emulsion is formed through high-speed shearing and microjet homogenization technology, avoiding the use of surfactants, and improving drug solubility and transdermal efficiency.

Benefits of technology

It improves the solubility and transdermal efficiency of Ceriborole, reduces the dosage of traditional emulsifiers, enhances the drug loading and stability of the drug, reduces skin irritation, reduces costs, and improves the efficacy of local preparations.

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Abstract

The invention discloses a crisaborole Pickering emulsion as well as a preparation method and application of the crisaborole Pickering emulsion. The crisaborole Pickering emulsion prepared by the invention solves the problem of poor water solubility of crisaborole, improves the drug solubility, and has the characteristics of small particle size, high centrifugal stability, good long-term stability and the like. Compared with the traditional nanoemulsion, the Pickering emulsion disclosed by the invention shows certain advantages in the aspects of biocompatibility, cumulative transdermal amount and cutin retention, improves the curative effect of a local preparation and reduces skin toxicity, and can be used as an ideal local preparation for treating atopic dermatitis and other diseases.
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