Sleep promoting composition for balancing magnetic field and microenvironment as well as preparation method and use method of sleep promoting composition

Abstract

The invention relates to the technical field of plant extracts and mineral extracts, and particularly discloses a sleep promoting composition for balancing a magnetic field and a microenvironment and a preparation and use method thereof.The sleep promoting composition is prepared from, by weight, 10-30 parts of plant powder, 0.5-1.7 parts of mercuric sulfide and 2-8 parts of a bonding matrix; wherein the plant powder comprises at least one of a component A for promoting dopamine secretion, a component B with an aromatic curative effect and a component C with a sedative effect; the adhesive matrix contains a silicate. Natural plants and minerals are adopted, the mind tranquilizing and sleep promoting effects provided by the plants and the improvement of the minerals on a micro magnetic field of a sleep environment are utilized, the traditional Chinese medicine does not need to be taken and is not close to the skin, sleep disorders are effectively improved, and drug dependence is reduced.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a sleep-promoting composition that balances magnetic field and microenvironment, and a preparation and use method thereof. Background Art

[0002] Nearly one-third of a person's life is spent sleeping. According to the World Health Organization, 27% of the global population experiences sleep problems. The "2024 Chinese Residents' Sleep Health White Paper," released by the China Sleep Research Society on March 21, 2024, shows that 64% of respondents experience sleep problems, while only 19% have no sleep problems at all. Scientific research shows that sleep, especially deep sleep, has an inhibitory effect on the hypothalamic-pituitary-adrenal (HPA) axis, and activation of the HPA axis can cause arousals or insomnia. Insomnia, as a stress response, activates the HPA axis, leading to elevated levels of cortisol, the terminal hormone of the HPA axis. Elevated blood cortisol levels may play a core pathophysiological role in insomnia. Serotonin regulates the sleep-wake cycle, primarily through its dual effects on the sleep-wake cycle: it promotes arousals and is essential for the onset of restful sleep. Insomnia can increase the activity of the HPA axis, which in turn causes changes in the content of some neurotransmitters, including an increase in norepinephrine synthesized and secreted by the adrenal medulla. Increased norepinephrine can enhance myocardial contractility, increase heart rate, and be detrimental to stable sleep.

[0003] The main reasons for modern people's sleep problems are: first, irregular sleep schedules. Frequent late nights and irregular sleep schedules can disrupt the biological clock and affect sleep quality. Second, stress and anxiety. Pressure from work, study, and daily life, as well as worry and uncertainty about the future, can lead to overexcited brains and difficulty relaxing, resulting in insomnia or poor sleep quality. In addition, external factors such as noise, light, and temperature can also affect sleep.

[0004] Currently, people use white noise, aromatherapy, massage, and other methods to help them fall asleep. Doctors will prescribe sleeping pills for patients with severe sleep problems. For example, patent application CN116983324A proposes using Ganoderma lucidum polysaccharides and melatonin to synergistically improve sleep quality. Melatonin is an amine hormone produced by the pineal gland of mammals and humans that can regulate sleep disorders. Another example is the solid beverage composition for improving sleep disorders provided by patent application CN115669840A, whose raw materials, nutmeg, Chinese date seeds, and gamma-aminobutyric acid, have sedative and hypnotic effects. As can be seen from the above, over-the-counter oral sleeping pills are mainly composed of traditional Chinese medicines and Chinese herbal extracts, represented by Chinese date seeds, and hormone products, represented by melatonin. However, oral medications have the problem of dependence and are prone to recurring after discontinuation of the medication. In view of this, the present invention aims to provide an external regulation method to improve sleep quality and reduce drug dependence. Summary of the Invention

[0005] In response to the problems existing in the prior art, the present invention uses readily available natural plants and minerals as raw materials, and utilizes the calming and sleep-inducing effects provided by the plants and the improvement of the micromagnetic field of the sleeping environment by the minerals to provide a sleep-promoting composition that does not require oral administration, has a significant effect on promoting the length and depth of sleep, and effectively reduces drug dependence.

[0006] In order to achieve the above object, the technical solution adopted by the present invention is:

[0007] A first aspect of the present invention provides a sleep-promoting composition for balancing a magnetic field and a microenvironment, comprising the following raw materials, by weight: 10 to 30 parts of plant powder, 0.2 to 1 part of mercuric sulfide, and 1 to 4 parts of an adhesive matrix; wherein the plant powder comprises at least one of component A for promoting dopamine secretion, component B for aromatic therapeutic effect, and component C for sedative effect; and the adhesive matrix contains silicate.

[0008] In some embodiments, the component A comprises 1 to 3 parts of patchouli powder and 1 to 3 parts of calamus powder, by weight.

[0009] In some embodiments, the component B comprises 1 to 3 parts of Perilla frutescens powder and 1 to 3 parts of Costus root powder, by weight.

[0010] In some embodiments, the component C comprises 5 to 15 parts of fired mugwort powder and 1 to 3 parts of ginseng powder, by weight.

[0011] The present invention promotes the length and depth of sleep by combining natural plants and minerals. The plant powder improves the negative emotions of insomnia patients through aromatherapy, and reduces the impact of emotions such as anxiety and depression on sleep. For example, when costus root and perilla are used in combination, they have a certain auxiliary effect on improving sleep; patchouli contains ingredients that can increase the secretion of neurotransmitters such as serotonin and dopamine, has a sedative effect, and can help relieve anxiety and stress; Acorus calamus can improve the function of the nervous system by increasing the content of neurotransmitters such as dopamine and acetylcholine in the brain; the fired mugwort can have a calming effect on the brain, thereby accelerating the speed of falling asleep and improving sleep quality; ginseng can relieve stress and anxiety, thereby improving sleep quality, but the dosage needs to be controlled to avoid causing excitement.

[0012] In some embodiments, the adhesive matrix is prepared as follows:

[0013] S1. Dissolve dehydrated castor oil triol and 4-dimethylaminopyridine with stirring at 100-150° C., then add succinic anhydride dissolved in butanone, and stir to react for 3-8 hours; cool to 50-100° C., add water, stir for 20-50 minutes, cool to room temperature, and wash until pH = 7 to obtain a yellow oil;

[0014] S2. Evenly mix the catalyst, water, silicate and the yellow oil obtained in step S1, then add the polyisocyanate prepolymer and stir until the mixture is in a stringy state to obtain a bonding matrix.

[0015] The adhesive matrix of the present invention has high viscosity, which can effectively bond plant powder and mercury sulfide. Secondly, the adhesive matrix will micro-foam during the room temperature curing process, that is, the effective substance will be pushed to the surface of the particles as the foaming occurs, which improves the utilization rate compared with solid particles. Thirdly, the introduced silicate not only stabilizes the porous structure of the matrix, but also, when used in combination with mercury sulfide, mercury sulfide can provide local magnetic regulation, and the silicate can interact with mercury sulfide through silicon-oxygen tetrahedrons, which helps mercury sulfide to form a more stable arrangement in the micromagnetic field, thereby improving the regulation effect of the magnetic field. Appropriate magnetic field regulation can reduce the time to fall asleep and improve the depth of sleep.

[0016] In some embodiments, in step S1, the mass ratio of the dehydrated castor oil triol to succinic anhydride is 1:(0.17-0.31).

[0017] In some embodiments, in step S2, the silicate is any one of K2SiO3, Na2SiO3, and Li2SiO3.

[0018] Alkali metal metasilicate Li2SiO3 can better regulate the performance of mercury sulfide in the magnetic field and help balance the magnetic field of the sleeping environment. The possible reason is that the metal ions in it have a larger electron cloud distribution and can interact with the mercury atoms in mercury sulfide through electron clouds. It is this electron cloud interaction that optimizes the magnetic state of mercury sulfide and balances the magnetic field of the sleeping environment.

[0019] In some embodiments, in step S2, the mass ratio of the yellow oil to the polyisocyanate prepolymer is 1:(0.9-1.7).

[0020] The present invention controls the viscosity of the adhesive matrix by controlling the mass ratio between the yellow oily substance and the polyisocyanate prepolymer.

[0021] The second aspect of the present invention provides a method for preparing the sleep-promoting composition, which comprises the following steps: firstly, mixing the plant powder and mercuric sulfide uniformly, then adding a bonding matrix and kneading them into granules, and then drying and solidifying them at room temperature to obtain the sleep-promoting composition.

[0022] The third aspect of the present invention provides a method for using the sleep-promoting composition, which comprises the following steps: placing the sleep-promoting composition under a pillow and a bed sheet.

[0023] The sleep-promoting composition provided by the present invention does not need to be taken orally and does not need to be placed close to the skin, thereby reducing drug dependence. The natural plant scent emitted can have a calming and sleep-inducing effect, and the minerals balance the micromagnetic field of the sleeping environment, thereby improving the microenvironment and promoting sleep.

[0024] Compared with the prior art, the present invention has the following beneficial effects:

[0025] 1. The present invention provides a sleep-promoting composition with readily available raw materials and a reasonable combination. The composition effectively improves people's sleep through the tranquilizing and hypnotic effects provided by plants and the improvement of the micromagnetic field of the sleeping environment by minerals. Patchouli and Acorus calamus are used to increase the secretion of dopamine in the brain and improve the function of the nervous system. On this basis, aromatherapy is combined to improve the negative emotions of insomniac patients and reduce the impact of emotions such as anxiety and depression on sleep. The composition is then combined with the natural effects of Chinese herbal medicines such as mugwort and ginseng to improve sleep.

[0026] 2. The present invention provides an adhesive matrix with high viscosity. After being mixed with plant powder and mercury sulfide, the plant powder and mercury sulfide will be pushed to the surface of the particles as foaming occurs during the curing process at room temperature, thereby improving the utilization rate compared to solid particles. The introduced silicate not only stabilizes the porous structure of the matrix, but also, when used in combination with mercury sulfide, can interact with mercury sulfide through silicon-oxygen tetrahedrons, thereby helping mercury sulfide to form a more stable arrangement in the micromagnetic field. Through the specific selection of silicate, the metal ions thereof interact with the electron clouds of mercury atoms in mercury sulfide, thereby balancing the magnetic field of the sleeping environment, improving the microenvironment, and promoting sleep.

[0027] 3. The present invention uses plants and minerals in combination, and utilizes traditional Chinese medicine and magnetic therapy to synergistically improve the length and depth of sleep. When used, it only needs to be placed under the pillow and bed sheet, and does not need to be taken orally, thereby reducing the toxic side effects of drugs on the human body and being safe to use. DETAILED DESCRIPTION

[0028] The present invention will be described below in conjunction with specific embodiments. It should be noted that the following examples are illustrative of the present invention and are intended only to illustrate the present invention and are not intended to limit the present invention. Other combinations and various modifications within the scope of the present invention may be made without departing from the spirit or scope of the present invention.

[0029] It is worth noting that the raw materials used in the following preparations and examples, unless otherwise specified, can be obtained from any commercially available manufacturer:

[0030] Polyisocyanate prepolymer model is SC7930.

[0031] Preparation Example 1

[0032] The preparation steps of bonding substrate A are as follows:

[0033] S1. Dissolve 300 g of dehydrated castor oil triol and 0.8 g of 4-dimethylaminopyridine under stirring at 130° C., then add 70 g of succinic anhydride dissolved in 100 mL of butanone, and stir for 6 h; cool to 70° C., add 60 mL of water, stir for 40 min, then cool to room temperature, and wash with water until pH = 7 to obtain a yellow oil;

[0034] S2. 0.3 mL of bismuth neodecanoate, 0.5 mL of water, 300 g of Li2SiO3, and 100 g of the yellow oil obtained in step S1 were mixed evenly, and then 130 g of polyisocyanate prepolymer was added and stirred until the mixture was in a stringy state to obtain an adhesive matrix A.

[0035] Preparation Example 2

[0036] The preparation steps of bonding substrate B are as follows:

[0037] S1. Dissolve 300 g of dehydrated castor oil triol and 0.8 g of 4-dimethylaminopyridine under stirring at 130° C., then add 70 g of succinic anhydride dissolved in 100 mL of butanone, and stir for 6 h; cool to 70° C., add 60 mL of water, stir for 40 min, then cool to room temperature, and wash with water until pH = 7 to obtain a yellow oil;

[0038] S2. Evenly mix 0.3 mL of bismuth neodecanoate, 0.5 mL of water, and 100 g of the yellow oil obtained in step S1, then add 130 g of polyisocyanate prepolymer and stir until the mixture becomes stringy to obtain adhesive matrix B.

[0039] Preparation Example 3

[0040] The preparation steps of the adhesive matrix C are different from those of Preparation Example 1 in that the amount of polyisocyanate prepolymer used is 80 g.

[0041] Preparation Example 4

[0042] The preparation steps of adhesive matrix D are different from those of Preparation Example 1 in that the amount of polyisocyanate prepolymer used is 180 g.

[0043] Example 1

[0044] A sleep-promoting composition for balancing a magnetic field and a microenvironment comprises the following raw materials: 20 parts of plant powder, comprising component A, component B, and component C; component A comprises 2 parts of patchouli powder and 2 parts of calamus powder; component B comprises 2 parts of perilla powder and 2 parts of costus root powder; component C comprises 10 parts of fired mugwort powder and 2 parts of ginseng powder; 1.1 parts of mercuric sulfide; and 5 parts of an adhesive matrix A.

[0045] The preparation method of the sleep-promoting composition in this embodiment comprises the following specific steps: first, the plant powder and mercuric sulfide are uniformly mixed, then the adhesive matrix A is added and kneaded into granules, and the granules are dried and solidified at room temperature to obtain the sleep-promoting composition.

[0046] Example 2

[0047] A sleep-promoting composition for balancing a magnetic field and a microenvironment comprises the following raw materials: 10 parts of plant powder, comprising component A, component B, and component C; component A comprises 1 part of patchouli powder and 1 part of calamus powder; component B comprises 1 part of perilla powder and 1 part of costus root powder; component C comprises 5 parts of fired mugwort powder and 1 part of ginseng powder; 0.5 part of mercuric sulfide; and 2 parts of an adhesive matrix A.

[0048] The preparation method of the sleep-promoting composition in this example is the same as that in Example 1.

[0049] Example 3

[0050] A sleep-promoting composition for balancing a magnetic field and a microenvironment, comprising the following raw materials: 30 parts of plant powder, comprising component A, component B, and component C; component A comprising 3 parts of patchouli powder and 3 parts of calamus powder; component B comprising 3 parts of perilla powder and 3 parts of costus root powder; component C comprising 15 parts of fired mugwort powder and 3 parts of ginseng powder; 1.7 parts of mercuric sulfide; and 8 parts of an adhesive matrix A.

[0051] The preparation method of the sleep-promoting composition in this example is the same as that in Example 1.

[0052] Example 4

[0053] This embodiment provides a sleep-promoting composition that balances the magnetic field and microenvironment and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that the adhesive matrix A is replaced by an equal portion of the adhesive matrix C.

[0054] Example 5

[0055] This embodiment provides a sleep-promoting composition that balances the magnetic field and microenvironment and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that the adhesive matrix A is replaced by an equal portion of the adhesive matrix D.

[0056] Example 6

[0057] A sleep-promoting composition for balancing a magnetic field and a microenvironment comprises the following raw materials: 20 parts of plant powder, including 5 parts of patchouli powder, 5 parts of calamus powder, 5 parts of euphratica powder, and 5 parts of costus root powder; 1.1 parts of mercuric sulfide; and 5 parts of an adhesive matrix A.

[0058] The preparation method of the sleep-promoting composition in this example is the same as that in Example 1.

[0059] Example 7

[0060] A sleep-promoting composition for balancing a magnetic field and a microenvironment comprises the following raw materials: 20 parts of plant powder, including 3 parts of patchouli powder, 3 parts of calamus powder, 11 parts of fired mugwort powder, and 3 parts of ginseng powder; 1.1 parts of mercuric sulfide; and 5 parts of an adhesive matrix A.

[0061] The preparation method of the sleep-promoting composition in this example is the same as that in Example 1.

[0062] Example 8

[0063] A sleep-promoting composition for balancing a magnetic field and a microenvironment comprises the following raw materials: 20 parts of plant powder, including 3 parts of perilla powder, 3 parts of costus root powder, 11 parts of fired mugwort leaf powder, and 3 parts of ginseng powder; 1.1 parts of mercuric sulfide; and 5 parts of an adhesive matrix A.

[0064] The preparation method of the sleep-promoting composition in this example is the same as that in Example 1.

[0065] Comparative Example 1

[0066] This comparative example provides a sleep-promoting composition that balances the magnetic field and the microenvironment and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that the adhesive matrix A is replaced by an equal portion of the adhesive matrix B.

[0067] Comparative Example 2

[0068] A sleep-promoting composition for balancing a magnetic field and a microenvironment comprises the following raw materials, measured by weight: 21.1 parts of mercuric sulfide; and 5 parts of an adhesive matrix A.

[0069] The preparation method of the sleep-promoting composition in this comparative example is the same as that in Example 1.

[0070] Performance testing:

[0071] Sleep quality test:

[0072] This test used the Pittsburgh Sleep Quality Index and the Stress Perception Scale to randomly screen 66 subjects with sleep quality problems and high stress (all informed consent volunteers, with Pittsburgh Sleep Quality Index scores of 15-21 and Stress Perception Scale scores of 42-56). They were randomly divided into 11 groups, namely experimental groups 1 to 10 and a control group. Experimental groups 1 to 10 correspond to Examples 1 to 8 and Comparative Examples 1 to 2, respectively. The compositions provided in Examples 1 to 8 and Comparative Examples 1 to 2 were kneaded into particles with a diameter of 1±0.1 cm under the same conditions. Six particles were placed under the pillows and sheets of the experimental group, while no particles were placed under the sheets of the control group. 8:00 p.m. on Day 0 of the experiment was designated as Time Point 1. From Day 1 to Day 7 of the experiment, the sleep of all subjects was monitored in real time on the nights of Day 0 and Day 7 of the experiment, respectively. The results are shown in Table 1.

[0073] The Pittsburgh Sleep Quality Index (PSQI) consists of 19 self-assessment items and 5 peer-assessed items. Only the scores for the self-assessment questions are counted for scoring. The 19 self-assessment items are divided into 7 factors, each scored from 0 to 3, with "0" indicating no difficulty, "1" indicating mild difficulty, "2" indicating moderate difficulty, and "3" indicating severe difficulty. The cumulative scores of each factor component are the total score of the PSQI, which ranges from 0 to 21. Higher scores indicate worse sleep quality. "0" indicates no difficulty, "21" indicates extreme difficulty in all aspects, and scores from 0 to 14 are in the normal range.

[0074] The Chinese 14-item PSS (Perceived Stress Scale) uses 14 questions to investigate the frequency of various situations over the past month, thereby reflecting actual perceived stress. Each question has five options: 0: Never; 1: Occasionally; 2: Sometimes; 3: Often; 4: Always. Scores range from 0 to 42, representing a normal range.

[0075] Table 1 Performance test results

[0076] Sleep time (h) Time to fall asleep (min) Average number of night awakenings (times) Average time to fall asleep again (min) Example 1 6.21 47.1 0.8 30.2 Example 2 5.94 52.6 1.4 35.4 Example 3 6.10 49.2 1.1 32.8 Example 4 5.86 54.9 1.3 35.7 Example 5 5.73 54.3 1.4 38.5 Example 6 5.48 58.9 1.7 41.8 Example 7 5.53 57.6 1.9 41.4 Example 8 5.52 57.0 1.5 39.3 Comparative Example 1 5.35 60.4 1.7 40.7 Comparative Example 2 5.24 60.1 2.0 45.1 control group 4.87 72.4 2.3 58.6

[0077] As shown in Table 1, compared to the control group, Examples 1-8 and Comparative Examples 1-2 all improved the subjects' sleep quality to some extent after 7 days of the experiment, demonstrating the effectiveness of the formulation of the present invention. Examples 1-3 demonstrated the most significant improvement in sleep duration and reduction in nighttime awakenings. Compared to Example 1, the amount of polyisocyanate prepolymer used in the adhesive matrix used in Examples 4-5 was modified during synthesis, but this had little impact on the sleep-improving effect of the active ingredient.

[0078] It can be seen from Example 1 and Comparative Example 2 that although cinnabar (mercury sulfide) has a calming effect, the improvement in sleep quality achieved by using minerals alone is not as good as the combined use of plants and minerals, as shown in the extension of the time it takes to fall asleep. Furthermore, combined with the average number of nighttime awakenings in Examples 6 to 8, it can be seen that the absence of some components of plant extracts will also reduce the effect of improving sleep.

[0079] Compared with Example 1, the adhesive matrix used in Comparative Example 1 does not contain silicate, which may affect the coordination with mercuric sulfide, resulting in less obvious improvement in sleep effect.

[0080] The embodiments and comparative examples described above do not impose any form of limitation on the present invention. Although the present invention has been disclosed as a preferred embodiment as above, it is not intended to limit the present invention. Any technician familiar with the present profession can make some changes or modifications to equivalent embodiments of equivalent changes using the technical content disclosed above without departing from the scope of the technical solution of the present invention. However, any simple modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention still fall within the scope of the technical solution of the present invention.

Claims

1. A sleep-promoting composition that balances magnetic field and microenvironment, characterized in that: The invention comprises the following raw materials in parts by weight: 10 to 30 parts of plant powder, 0.5 to 1.7 parts of mercuric sulfide, and 2 to 8 parts of an adhesive matrix; wherein the plant powder comprises at least one of component A for promoting dopamine secretion, component B with aromatic therapeutic effect, and component C with a sedative effect; and the adhesive matrix contains silicate.

2. The sleep-promoting composition according to claim 1, characterized in that In parts by weight, the component A comprises 1 to 3 parts of patchouli powder and 1 to 3 parts of calamus powder.

3. The sleep-promoting composition according to claim 1, characterized in that In parts by weight, the component B comprises 1 to 3 parts of perilla powder and 1 to 3 parts of costus root powder.

4. The sleep-promoting composition according to claim 1, characterized in that In parts by weight, the component C comprises 5 to 15 parts of fired mugwort powder and 1 to 3 parts of ginseng powder.

5. The sleep-promoting composition according to claim 1, characterized in that The preparation steps of the bonding matrix are as follows: S1. Dissolve dehydrated castor oil triol and 4-dimethylaminopyridine with stirring at 100-150° C., then add succinic anhydride dissolved in butanone, and stir to react for 3-8 hours; cool to 50-100° C., add water, stir for 20-50 minutes, cool to room temperature, and wash until pH = 7 to obtain a yellow oil; S2. Evenly mix the catalyst, water, silicate and the yellow oil obtained in step S1, then add the polyisocyanate prepolymer and stir until the mixture is in a stringy state to obtain a bonding matrix.

6. The sleep-promoting composition according to claim 5, characterized in that In step S1, the mass ratio of the dehydrated castor oil triol to succinic anhydride is 1:(0.17-0.31).

7. The sleep-promoting composition according to claim 5, characterized in that In step S2, the silicate is any one of K2SiO3, Na2SiO3, and Li2SiO3.

8. The sleep-promoting composition according to claim 5, characterized in that In step S2, the mass ratio of the yellow oil to the polyisocyanate prepolymer is 1:(0.9-1.7).

9. A method for preparing the sleep-promoting composition according to any one of claims 1 to 8, characterized in that: The specific steps are as follows: firstly, the plant powder and mercuric sulfide are evenly mixed, then an adhesive matrix is added and kneaded into particles, and the particles are dried and solidified at room temperature to obtain a sleep-promoting composition.

10. A method for using the sleep-promoting composition according to any one of claims 1 to 8 and the sleep-promoting composition obtained by the preparation method according to claim 9, comprising the following steps: placing the sleep-promoting composition under a pillow and a bed sheet.