Traditional Chinese medicine formula for effectively reducing serum creatinine toxin as well as preparation method and application of traditional Chinese medicine formula

Abstract

The invention relates to a traditional Chinese medicine formula for effectively reducing serum creatinine toxin as well as a preparation method and application thereof, and relates to the technical field of traditional Chinese medicine, the traditional Chinese medicine formula comprises the following raw materials in parts by weight: 15-25 parts of dried ginger, 10-20 parts of radix aconiti lateralis preparata, 10-20 parts of fresh ginger, 3-8 parts of cinnamon, 3-7 parts of fructus amomi, 5-10 parts of cassia twig, 10-20 parts of bighead atractylodes rhizome, 8-12 parts of salvia miltiorrhiza, 8-12 parts of codonopsis pilosula, 8-12 parts of honey-fried licorice root, 10-20 parts of poria cocos and 10-20 parts of charred rheum officinale. According to the traditional Chinese medicine formula provided by the invention, the effects are enhanced, the body resistance is strengthened, the pathogenic factors are eliminated, the spleen and stomach are protected, the kidney qi and yang qi are protected, acupuncture therapy is assisted, the effects of dredging, clearing and tonifying are achieved, and a new treatment method is provided for reducing serum creatinine toxin and treating renal failure.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine formula for effectively reducing blood creatinine toxins, and a preparation method and application thereof. Background Art

[0002] Serum creatinine is an endogenous toxin produced by human muscle metabolism and is mainly excreted from the body through glomerular filtration. When renal function is impaired (such as chronic kidney disease, acute kidney injury or drug-induced renal damage), the excretion of serum creatinine is blocked, causing it to accumulate in the blood, leading to serious complications such as water and sodium retention, electrolyte imbalance, acidosis and anemia, and even progressing to uremia. Secondly, for patients with kidney disease, most have spleen and stomach deficiency, which leads to kidney failure. At present, clinical methods for lowering serum creatinine include dietary regulation (such as limiting protein intake), drug therapy (such as diuretics, antihypertensive drugs and nephrotoxic drug replacement) and dialysis treatment, but the above methods have limitations: dietary control requires long-term strict management and poor patient compliance; Western medicine treatment may cause electrolyte imbalance or increase the burden on the kidneys; dialysis treatment is effective but costly and cannot reverse renal damage.

[0003] Traditional Chinese medicine has unique advantages in lowering blood creatinine. Existing studies have shown that Chinese herbs such as rhubarb, salvia miltiorrhiza, and astragalus can promote creatinine excretion through mechanisms such as promoting blood circulation and removing blood stasis, clearing the bowels and purging turbidity, and strengthening the spleen and kidney. For example, emodin in rhubarb can inhibit glomerular mesangial cell proliferation, tanshinone in salvia miltiorrhiza can improve renal microcirculation, and astragalus polysaccharide can alleviate renal interstitial fibrosis by regulating immune function. However, traditional Chinese medicine formulas have problems such as complex ingredients, unclear mechanisms of action, and large individual differences in efficacy. Long-term use of some single herbs (such as rhubarb) may lead to intestinal flora imbalance or electrolyte imbalance, and the lack of standardized preparation technology for compound prescriptions leads to insufficient drug stability.

[0004] Yang-boosting and health-preserving is one of the core concepts of Chinese medicine. It takes "Yang Qi as the basis of life" as its theoretical foundation. It strengthens the body, strengthens the spleen and stomach, prevents diseases, and delays aging by warming and replenishing Yang Qi and harmonizing the balance of Yin and Yang. At present, there are few Chinese medicines on the market that use the pharmacology of Yang-boosting and health-preserving to treat kidney diseases, and the effects are not good. Summary of the Invention

[0005] To solve the above problems, the present invention provides a traditional Chinese medicine formula for effectively reducing blood creatinine toxins, as well as a preparation method and application thereof.

[0006] In a first aspect, the present invention provides a traditional Chinese medicine formula for effectively reducing blood creatinine toxins, wherein the traditional Chinese medicine formula comprises the following raw materials in parts by weight:

[0007] 15-25 parts of dried ginger, 10-20 parts of processed aconite root, 10-20 parts of fresh ginger, 3-8 parts of cinnamon bark, 3-7 parts of Amomum villosum, 5-10 parts of cassia twig, 10-20 parts of Atractylodes macrocephala, 8-12 parts of Salvia miltiorrhiza, 8-12 parts of Codonopsis pilosula, 8-12 parts of roasted liquorice root, 10-20 parts of Poria cocos, and 10-20 parts of charred rhubarb.

[0008] Furthermore, the Chinese medicine formula comprises the following raw materials in parts by weight:

[0009] 20 parts of dried ginger, 15 parts of processed aconite root, 15 parts of fresh ginger, 6 parts of cinnamon bark, 5 parts of Amomum villosum, 8 parts of cassia twig, 15 parts of Atractylodes macrocephala, 10 parts of Salvia miltiorrhiza, 10 parts of Codonopsis pilosula, 10 parts of roasted liquorice root, 15 parts of Poria cocos, and 15 parts of charcoaled rhubarb.

[0010] Furthermore, the Chinese medicine formula comprises the following raw materials in parts by weight:

[0011] 15 parts of dried ginger, 10 parts of processed aconite root, 10 parts of fresh ginger, 3 parts of cinnamon bark, 3 parts of Amomum villosum, 5 parts of cassia twig, 10 parts of Atractylodes macrocephala, 8 parts of Salvia miltiorrhiza, 8 parts of Codonopsis pilosula, 8 parts of roasted Licorice root, 10 parts of Poria cocos, and 10 parts of charcoaled rhubarb.

[0012] Furthermore, the Chinese medicine formula comprises the following raw materials in parts by weight:

[0013] 25 parts of dried ginger, 20 parts of processed aconite root, 20 parts of fresh ginger, 8 parts of cinnamon bark, 7 parts of Amomum villosum, 10 parts of cassia twig, 20 parts of Atractylodes macrocephala, 12 parts of Salvia miltiorrhiza, 12 parts of Codonopsis pilosula, 12 parts of roasted liquorice root, 20 parts of Poria cocos, and 20 parts of charcoaled rhubarb.

[0014] In a second aspect, based on the same inventive concept, the present invention provides a method for preparing a traditional Chinese medicine formula for effectively reducing blood creatinine toxins as described in any one of the first aspects, the preparation method comprising:

[0015] Adding the prepared aconite root into water for a first decoction to obtain a first mixed material;

[0016] adding the remaining raw materials in the traditional Chinese medicine formula to the first mixed material for a second decoction to obtain a second mixed material;

[0017] The second mixed material is filtered to obtain the traditional Chinese medicine formula.

[0018] Furthermore, based on 100 g of the traditional Chinese medicine formula, the amount of water added is 2000-2500 ml.

[0019] Furthermore, the first decoction time is 60 to 90 minutes.

[0020] Furthermore, based on 100 g of the traditional Chinese medicine formula, the endpoint of the second decoction is that the volume of the second mixture is 1000-1200 ml.

[0021] In a third aspect, the present invention provides use of the traditional Chinese medicine formula for effectively reducing blood creatinine toxins as described in any one of the first and second aspects in the preparation of a drug for treating renal failure.

[0022] Furthermore, the application includes the combined use of the traditional Chinese medicine formula for effectively reducing blood creatinine toxins described in any one of the first aspect and the second aspect, the external treatment method of supporting yang through moxibustion, and the external treatment method of supporting yang through acupuncture.

[0023] The above technical solution provided by the embodiment of the present invention has at least the following advantages compared with the prior art:

[0024] The embodiments of the present invention provide a traditional Chinese medicine formula for effectively reducing blood creatinine toxins, as well as a preparation method and application thereof. The traditional Chinese medicine formula provided by the present invention, through maintaining the traditional principles and making innovations, utilizes ancient prescriptions for modification and adaptation, takes advantage of their benefits, enhances their efficacy, strengthens the body's resistance, dispels evil, protects the spleen and stomach, and preserves kidney qi and yang, and is supplemented by acupuncture treatment to play the role of clearing and replenishing the body. With the core theory of supporting yang and maintaining health, the traditional Chinese medicine formula provides a new treatment method for reducing blood creatinine toxins and treating renal failure. DETAILED DESCRIPTION

[0025] To make the objectives, technical solutions, and advantages of the embodiments of the present invention more clear, the technical solutions in the embodiments of the present invention are clearly and completely described below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. All other embodiments obtained by ordinary technicians in this field based on the embodiments of the present invention without making any creative efforts are within the scope of protection of the present invention.

[0026] Unless otherwise specified, various raw materials, reagents, instruments and equipment used in the present invention can be purchased from the market or prepared by existing methods.

[0027] The present invention will be further described below in conjunction with specific examples. It should be understood that these examples are intended to illustrate the present invention only and are not intended to limit the scope of the invention. The experimental methods in the following examples where specific conditions are not specified are generally measured in accordance with national standards. If there are no corresponding national standards, then the methods are carried out in accordance with general international standards, conventional conditions, or the conditions recommended by the manufacturer.

[0028] Example 1

[0029] This example provides a traditional Chinese medicine formula that effectively reduces blood creatinine toxins. The traditional Chinese medicine formula includes the following raw materials in parts by weight:

[0030] 20 parts of dried ginger, 15 parts of processed aconite root, 15 parts of fresh ginger, 6 parts of cinnamon bark, 5 parts of Amomum villosum, 8 parts of cassia twig, 15 parts of Atractylodes macrocephala, 10 parts of Salvia miltiorrhiza, 10 parts of Codonopsis pilosula, 10 parts of roasted liquorice root, 15 parts of Poria cocos, and 15 parts of charcoaled rhubarb.

[0031] The above-mentioned method for preparing the Chinese medicine formula comprises:

[0032] Adding the prepared aconite root into water for a first decoction to obtain a first mixed material;

[0033] adding the remaining raw materials in the traditional Chinese medicine formula to the first mixed material for a second decoction to obtain a second mixed material;

[0034] filtering the second mixed material to obtain the traditional Chinese medicine formula;

[0035] Among them, based on 100g of the traditional Chinese medicine formula, the amount of water added is 2200ml; the time of the first decoction is 75 minutes; based on 100g of the traditional Chinese medicine formula, the end point of the second decoction is that the volume of the second mixture is 1100ml.

[0036] Example 2

[0037] This example provides a traditional Chinese medicine formula that effectively reduces blood creatinine toxins. The traditional Chinese medicine formula includes the following raw materials in parts by weight:

[0038] 15 parts of dried ginger, 10 parts of processed aconite root, 10 parts of fresh ginger, 3 parts of cinnamon bark, 3 parts of Amomum villosum, 5 parts of cassia twig, 10 parts of Atractylodes macrocephala, 8 parts of Salvia miltiorrhiza, 8 parts of Codonopsis pilosula, 8 parts of roasted Licorice root, 10 parts of Poria cocos, and 10 parts of charcoaled rhubarb.

[0039] The above-mentioned method for preparing the Chinese medicine formula comprises:

[0040] Adding the prepared aconite root into water for a first decoction to obtain a first mixed material;

[0041] adding the remaining raw materials in the traditional Chinese medicine formula to the first mixed material for a second decoction to obtain a second mixed material;

[0042] filtering the second mixed material to obtain the traditional Chinese medicine formula;

[0043] Among them, based on 100g of the traditional Chinese medicine formula, the amount of water added is 2200ml; the time of the first decoction is 75 minutes; based on 100g of the traditional Chinese medicine formula, the end point of the second decoction is that the volume of the second mixture is 1100ml.

[0044] Example 3

[0045] This example provides a traditional Chinese medicine formula that effectively reduces blood creatinine toxins. The traditional Chinese medicine formula includes the following raw materials in parts by weight:

[0046] 25 parts of dried ginger, 20 parts of processed aconite root, 20 parts of fresh ginger, 8 parts of cinnamon bark, 7 parts of Amomum villosum, 10 parts of cassia twig, 20 parts of Atractylodes macrocephala, 12 parts of Salvia miltiorrhiza, 12 parts of Codonopsis pilosula, 12 parts of roasted liquorice root, 20 parts of Poria cocos, and 20 parts of charcoaled rhubarb.

[0047] The above-mentioned method for preparing the Chinese medicine formula comprises:

[0048] Adding the prepared aconite root into water for a first decoction to obtain a first mixed material;

[0049] adding the remaining raw materials in the traditional Chinese medicine formula to the first mixed material for a second decoction to obtain a second mixed material;

[0050] filtering the second mixed material to obtain the traditional Chinese medicine formula;

[0051] Among them, based on 100g of the traditional Chinese medicine formula, the amount of water added is 2200ml; the time of the first decoction is 75 minutes; based on 100g of the traditional Chinese medicine formula, the end point of the second decoction is that the volume of the second mixture is 1100ml.

[0052] Test Case

[0053] The Chinese medicine formula obtained in Example 1 was used to treat patients with renal failure, and conventional dialysis treatment was used as a comparison.

[0054] Case inclusion criteria: Kidney Disease Improving Global Outcomes (KDIGO) guidelines: chronic renal failure (CKD stage 5) glomerular filtration rate (GFR) <15ml / min / 1.75m 2 , which belongs to end-stage renal disease (ESRD). At this time, the kidneys cannot effectively remove metabolic waste and regulate fluid balance, and dialysis or kidney transplantation is required to maintain life.

[0055] Treatment plan: Yang-boosting triple therapy: Yang-boosting decoction, Yang-boosting moxibustion, and Yang-boosting acupuncture

[0056] Internal use of Fuyang Decoction: warms the middle and warms the yang, promotes blood circulation and removes blood stasis, removes dampness and strengthens the spleen, and nourishes the yang and kidneys

[0057] External treatment method: moxibustion to support yang: warm the meridians and dispel cold, expel cold and dampness, promote qi and relieve blood stasis, replenish yang and consolidate deficiency

[0058] External treatment method: Yang-supporting acupuncture: warming the meridians and dispelling cold, regulating qi and removing stagnation, activating blood circulation and removing blood stasis, strengthening the spleen and kidney, and consolidating the foundation and nourishing the vital energy.

[0059] For case reference, please refer to the PPT introduction.

[0060] After 8 years, 368 cases were treated with chronic renal failure (CKD stage 5) as defined by international standards, with a treatment efficacy rate of over 90%.

[0061] About 28.7% of patients experienced renal failure reversal or cessation of progression for 2 years or more.

[0062] The rate of non-dialysis patients was 90.6% with a one-year delay as the standard.

[0063] The two-year delay reached 78.3%.

[0064] 50.7% of patients were delayed for more than three years and then transferred to the Yang-boosting and less dialysis group.

[0065] The longest time without dialysis was 6 years.

[0066] According to clinical treatment standards, all patients were diagnosed with chronic renal failure stage 5 (CKD stage 5) in other tertiary hospitals. The patients required conventional dialysis 2-3 times / week, while the Fuyang TCM treatment group required dialysis 1-4 times / month. In our research cohort, patients who required dialysis more than 5 times / month or had a urine output of <1200 ml / day were discharged from the Fuyang TCM treatment group and entered the conventional dialysis group.

[0067] The test results are shown in Table 1.

[0068] Table 1 Comparison of Example 1 and dialysis treatment of renal failure (serum creatinine 500-700)

[0069] index Example 1 Treatment Group Dialysis treatment group Urine volume Normal urine output Decreased urine output or no urine output Heart failure none Happens frequently High potassium None or very little Happens frequently anemia Normal or mild Moderate or severe Auxiliary medication Little or no Protect heart, lower blood pressure, calcium and phosphorus, etc. Work Normal work Unemployment or inability to work complication none More and more

[0070] Various embodiments of the present invention may be presented in the form of a range; it should be understood that the description in a range format is only for convenience and brevity and should not be construed as an inflexible limitation on the scope of the invention; therefore, the range description should be considered to have specifically disclosed all possible subranges and single numerical values within the range. For example, the description of a range from 1 to 6 should be considered to have specifically disclosed subranges such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6, etc., as well as single numbers within the range, such as 1, 2, 3, 4, 5, and 6, regardless of the range. In addition, whenever a numerical range is indicated herein, it is intended to include any cited numeral (fractional or integer) within the indicated range.

[0071] The foregoing description is intended only to provide specific embodiments of the present invention, which will enable those skilled in the art to understand and implement the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention is not intended to be limited to the embodiments shown herein, but is intended to be accorded the widest scope consistent with the principles and novel features claimed herein.

Claims

1. A Chinese medicine formula for effectively reducing blood creatinine toxin, characterized in that: The Chinese medicine formula includes the following raw materials in parts by weight: 15-25 parts of dried ginger, 10-20 parts of processed aconite root, 10-20 parts of fresh ginger, 3-8 parts of cinnamon bark, 3-7 parts of Amomum villosum, 5-10 parts of cassia twig, 10-20 parts of Atractylodes macrocephala, 8-12 parts of Salvia miltiorrhiza, 8-12 parts of Codonopsis pilosula, 8-12 parts of roasted liquorice root, 10-20 parts of Poria cocos, and 10-20 parts of charred rhubarb.

2. The Chinese medicine formula for effectively reducing blood creatinine toxin according to claim 1, characterized in that: The Chinese medicine formula includes the following raw materials in parts by weight: 20 parts of dried ginger, 15 parts of processed aconite root, 15 parts of fresh ginger, 6 parts of cinnamon bark, 5 parts of Amomum villosum, 8 parts of cassia twig, 15 parts of Atractylodes macrocephala, 10 parts of Salvia miltiorrhiza, 10 parts of Codonopsis pilosula, 10 parts of roasted liquorice root, 15 parts of Poria cocos, and 15 parts of charcoaled rhubarb.

3. The Chinese medicine formula for effectively reducing blood creatinine toxin according to claim 1, characterized in that: The Chinese medicine formula includes the following raw materials in parts by weight: 15 parts of dried ginger, 10 parts of processed aconite root, 10 parts of fresh ginger, 3 parts of cinnamon bark, 3 parts of Amomum villosum, 5 parts of cassia twig, 10 parts of Atractylodes macrocephala, 8 parts of Salvia miltiorrhiza, 8 parts of Codonopsis pilosula, 8 parts of roasted Licorice root, 10 parts of Poria cocos, and 10 parts of charcoaled rhubarb.

4. The Chinese medicine formula for effectively reducing blood creatinine toxin according to claim 1, characterized in that: The Chinese medicine formula includes the following raw materials in parts by weight: 25 parts of dried ginger, 20 parts of processed aconite root, 20 parts of fresh ginger, 8 parts of cinnamon bark, 7 parts of Amomum villosum, 10 parts of cassia twig, 20 parts of Atractylodes macrocephala, 12 parts of Salvia miltiorrhiza, 12 parts of Codonopsis pilosula, 12 parts of roasted liquorice root, 20 parts of Poria cocos, and 20 parts of charcoaled rhubarb.

5. A method for preparing the Chinese medicinal formula for effectively reducing blood creatinine toxin according to any one of claims 1 to 4, characterized in that: The preparation method comprises: Adding the prepared aconite root into water for a first decoction to obtain a first mixed material; adding the remaining raw materials in the traditional Chinese medicine formula to the first mixed material for a second decoction to obtain a second mixed material; The second mixed material is filtered to obtain the traditional Chinese medicine formula.

6. The method for preparing the Chinese medicinal formula for effectively reducing blood creatinine toxin according to claim 5, characterized in that: Based on 100g of the traditional Chinese medicine formula, the amount of water added is 2000-2500ml.

7. The method for preparing the Chinese medicinal formula for effectively reducing blood creatinine toxin according to claim 1, characterized in that: The first decoction time is 60 to 90 minutes.

8. The method for preparing the Chinese medicinal formula for effectively reducing blood creatinine toxin according to claim 1, characterized in that: Based on 100 g of the traditional Chinese medicine formula, the endpoint of the second decoction is that the volume of the second mixture is 1000-1200 ml.

9. Use of the traditional Chinese medicine formula for effectively reducing blood creatinine toxin according to any one of claims 1 to 8 in the preparation of a drug for treating renal failure.

10. The use according to claim 9, characterized in that The application comprises the combined use of the Chinese medicinal formula for effectively reducing blood creatinine toxins according to any one of claims 1 to 8, external treatment methods of supporting yang through moxibustion, and external treatment methods of supporting yang through acupuncture.