External medicine for promoting discharge of urinary calculi

By mixing yellow dan, black pepper, Glauber's salt, alum and aged vinegar on the urethra, the problem that the drug is difficult to directly act on the lesions is solved, and efficient and safe treatment of urinary stones is achieved.

CN120478456APending Publication Date: 2025-08-15CHENYANG RUIYANG PHARMACEUTICAL CO LTD
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Patent Information

Application Number
CN202510783675.6
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-06-12
Publication Date
2025-08-15

AI Technical Summary

Technical Problem

When existing traditional Chinese medicine preparations treat urinary stones, it is difficult for the effective ingredients of the drug to act directly on the lesions, resulting in slow efficacy, low cure rate and gastrointestinal discomfort.

Method used

The topical drug formula is adopted, including yellow dan, black pepper, Glauber's salt and alum. It is mixed with aged vinegar and applied externally to the urethra opening. The drug ingredients directly reach the lesion, and the medicinal properties of each component enhance penetration and therapeutic effect.

Benefits of technology

The drug ingredients can directly act on the lesions, avoiding gastrointestinal discomfort, fast efficacy, high cure rate, low cost, safe and convenient.

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Abstract

The invention provides an external medicine for promoting discharge of urinary calculi, and belongs to the technical field of traditional Chinese medicine preparations for calculi, the external medicine for promoting discharge of urinary calculi is prepared from, by weight, 3-6 parts of yellow lead, 2-4 parts of black pepper, 3-6 parts of mirabilite and 3-6 parts of alumen, the external medicine for promoting discharge of urinary calculi is used for external application, and before external application, the external medicine for promoting discharge of urinary calculi is used for promoting discharge of urinary calculi. The urinary system calculus discharge promoting external medicine is mixed with mature vinegar to obtain paste, and then the paste is externally applied to the urethral orifice of a patient. The external medicine for promoting excretion of urinary calculus provided by the invention is low in cost, simple in preparation method, free of toxic and side effects, quick in effect taking and high in cure rate, and the medicinal components can directly reach the focus.
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Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine preparations for stones, and particularly relates to an external medicine for promoting the excretion of urinary stones. Background Art

[0002] Urinary stones are one of the common clinical diseases, causing great pain to patients. Existing treatment methods, such as extracorporeal shock wave lithotripsy, ureteroscopy and percutaneous nephrolithotomy, are not only expensive and time-consuming, but also cause physical pain to patients.

[0003] my country's traditional Chinese medicine treatment methods are relatively mild. Generally, stones are dispelled and expelled by taking Chinese herbal preparations, such as stone-eliminating agents and stone-removing granules. However, most Chinese herbal preparations are oral medications, which can easily cause gastrointestinal discomfort. At the same time, due to the body's internal absorption and diffusion effects, the effective ingredients of the drugs are difficult to act directly on the lesion site, the drug effect is slow, the cure rate is low, and it is difficult to achieve ideal treatment results. Summary of the Invention

[0004] In order to solve the problems existing in the background technology, the present invention provides an external-use medicine for promoting the excretion of urinary stones. The drug ingredients can directly reach the lesion, have no toxic side effects, have a fast efficacy, and a high cure rate.

[0005] In order to achieve the above object, the present invention provides the following technical solutions:

[0006] A urinary stone excretion-promoting external-use medicine is prepared from the following raw materials, measured by weight: 3-6 parts of yellow lead, 2-4 parts of black pepper, 3-6 parts of sodium sulfate and 3-6 parts of alum.

[0007] Furthermore, the external medicine for promoting the excretion of urinary stones is prepared from the following raw materials in parts by weight: 4.5 parts of yellow lead, 3 parts of black pepper, 4.5 parts of sodium sulfate and 4.5 parts of alum.

[0008] Furthermore, the external medicine for promoting the excretion of urinary stones is stored in a light-proof and heat-insulated manner.

[0009] Furthermore, the external medicine for promoting the excretion of urinary stones is stored in a vacuum-sealed manner at room temperature.

[0010] Furthermore, the external medicine for promoting the excretion of urinary stones is used by external application. Before external application, the external medicine for promoting the excretion of urinary stones is mixed with aged vinegar to obtain a paste.

[0011] Furthermore, the external application site of the urinary stone excretion-promoting medicine is the patient's urethral opening, and the external application time is 2-3 hours.

[0012] Furthermore, for male patients, the method of use of the external medicine for promoting the excretion of urinary stones includes the following: pouring the paste obtained from the external medicine for promoting the excretion of urinary stones into an external application bag, and then inserting the penis into the external application bag, turning back the foreskin when inserting, so that the external application bag is in close contact with the urethral opening.

[0013] Furthermore, for female patients, the method of use of the external medicine for promoting the excretion of urinary stones includes the following: pouring the paste obtained from the external medicine for promoting the excretion of urinary stones into the center of the external patch, and then applying the external patch to the urethral opening, pulling apart the labia majora when applying the patch, so that the external patch is in close contact with the urethral opening.

[0014] Furthermore, for the external medication for promoting the excretion of urinary stones, the patient should sweat 10-30 minutes in advance before taking the medication. At the same time, the patient is prohibited from using air conditioning or fans before and after taking the medication to avoid catching a cold. After taking the medication, the body is allowed to sweat naturally.

[0015] The present invention also provides a preparation method of an external medicine for promoting the excretion of urinary stones. The method comprises the following steps: weighing yellow ochre, black pepper, sodium sulfate and alum in parts by weight, grinding each raw material separately until they are powdered, mixing each powdered raw material to obtain a mixed powder, that is, obtaining the external medicine for promoting the excretion of urinary stones.

[0016] The compatibility relationship of the traditional Chinese medicine prescription provided by the present invention is as follows: the monarch drug is yellow ochre, also known as lead ochre, which has the functions of removing toxins, promoting tissue regeneration, killing insects and relieving itching. Yellow ochre is the core of the prescription and directly exerts the effect of detoxification and astringing sores for the main symptoms such as sores, swelling, eczema, scabies and tinea, and is a commonly used medicine for external treatment of skin diseases; the ministerial drugs are alum and sodium sulfate. Alum can dry out dampness and relieve itching, detoxify and kill insects, and assists yellow ochre in enhancing the power of drying dampness and astringency, and is particularly suitable for exudative eczema or ulcers. Its sour and astringent nature can protect the sore surface. Sodium sulfate can clear away heat and reduce swelling, soften and disperse nodules, and cooperates with yellow ochre to resolve heat and toxins, and is especially good at dissipating redness, swelling and induration, and is often used for heat and toxin stagnation. At the beginning of sores and carbuncles; the adjuvant is black pepper, which can dispersing heat, promote qi and blood circulation, counteract coldness and promote penetration. Huang Dan, Glauber's Salt and Alum are all cold in nature. The pungent heat of black pepper can prevent excessive coldness and avoid stagnation of qi and blood. At the same time, its pungent and dispersing nature enhances local blood circulation and helps the medicine penetrate deeply into the diseased area. In addition, aged vinegar has strong penetrating power and can effectively integrate the effective components of the medicine. When applied externally, the drug ingredients can reach the lesion directly and can be better absorbed by the human body, thereby enhancing the therapeutic effect of the entire prescription, and ultimately making the combined medicine achieve the effects of clearing away heat, dampness and detoxification, and playing a role of diuresis, relieving stranguria and dilating the ureters and urinary tract.

[0017] This application has the following beneficial effects:

[0018] 1. The external-use medicine for promoting the excretion of urinary stones provided by the present invention is made of common Chinese medicinal materials as raw materials, has low cost, simple preparation method, does not require complicated processes and equipment, is safe and convenient to use, and avoids the physical trauma and risks brought to patients by traditional treatment methods. The drug ingredients can directly reach the lesion, have no toxic side effects, have a fast efficacy, and a high cure rate, providing a new and effective treatment option for patients with urinary stones.

[0019] 2. The external medicine for promoting the excretion of urinary stones provided by the present invention has a reasonable drug combination, and the main, auxiliary and adjuvant drugs cooperate with each other. By using yellow lead, sodium sulfate, alum and black pepper in combination, it can not only effectively treat the symptoms of urinary stones, but also avoid the adverse effects of excessive coldness of the drugs on the body. When taking the medicine, it is supplemented with aged vinegar to promote drug penetration, so that the drug power can better act on the lesion and achieve the best therapeutic effect. DETAILED DESCRIPTION

[0020] The present application is further described in detail below with reference to the embodiments.

[0021] Unless otherwise specified, the raw materials used in the examples and comparative examples of the present application are all commercially available.

[0022] Example 1

[0023] A urinary stone excretion-promoting external-use medicine is prepared by the following steps: weighing, by weight, 4.5 parts of yellow ochre, 3 parts of black pepper, 4.5 parts of sodium sulfate, and 4.5 parts of alum; grinding the yellow ochre, black pepper, sodium sulfate, and alum separately until they are powdered; and mixing the ground powdered raw materials to obtain a mixed powder, namely, the urinary stone excretion-promoting external-use medicine;

[0024] Before applying the medicine externally, use 6-degree Shanxi aged vinegar to mix with the mixed preparation. The specific mixing process is to first add the aged vinegar to the external medicine for promoting the excretion of urinary stones. After adding, heat it with the palm of your hand to allow the medicine and the aged vinegar to fully contact and mix to obtain a paste, and then apply it externally for treatment.

[0025] Example 2

[0026] A urinary stone excretion-promoting external-use medicine is prepared by the following steps: weighing, by weight, 6 parts of yellow ochre, 2 parts of black pepper, 3 parts of mirabilite, and 3 parts of alum; grinding the yellow ochre, black pepper, mirabilite, and alum separately until they are powdered; and mixing the ground powdered raw materials to obtain a mixed powder, namely, the urinary stone excretion-promoting external-use medicine;

[0027] Before applying the medicine externally, use 6-degree Shanxi aged vinegar to mix with the mixed preparation. The specific mixing process is to first add the aged vinegar to the external medicine for promoting the excretion of urinary stones. After adding, heat it with the palm of your hand to allow the medicine and the aged vinegar to fully contact and mix to obtain a paste, and then apply it externally for treatment.

[0028] Example 3

[0029] A urinary stone excretion-promoting external-use medicine is prepared by the following steps: weighing, by weight, 3 parts of yellow ochre, 4 parts of black pepper, 6 parts of mirabilite, and 6 parts of alum; grinding the yellow ochre, black pepper, mirabilite, and alum separately until they are powdered; and mixing the powdered raw materials obtained by grinding to obtain a mixed powder, namely, the urinary stone excretion-promoting external-use medicine;

[0030] Before applying the medicine externally, use 6-degree Shanxi aged vinegar to mix with the mixed preparation. The specific mixing process is to first add the aged vinegar to the external medicine for promoting the excretion of urinary stones. After adding, heat it with the palm of your hand to allow the medicine and the aged vinegar to fully contact and mix to obtain a paste, and then apply it externally for treatment.

[0031] Proven effectiveness

[0032] Through clinical trials, patients were divided into three groups, with 35 people in each group. They were treated with the stone-promoting external medicine prepared in Examples 1-3 of the present invention, with 3 weeks as one course of treatment and the medicine taken twice a week. The efficacy and cure rate of the patients after two courses of treatment were calculated. The efficacy rate was the proportion of patients with no stones, smaller stones or alleviated symptoms after B-ultrasound reexamination after treatment, and the cure rate was the proportion of patients with no stones after B-ultrasound reexamination after treatment. The specific treatment results are shown in Table 1:

[0033] Table 1

[0034] Effectiveness% Cure rate% Example 1 97.1 77.1 Example 2 94.2 74.3 Example 3 91.4 71.4

[0035] Result Analysis

[0036] From the analysis of Examples 1-3 and the data in Table 1, it can be seen that the stone-promoting external-use medicine provided by the present invention has an efficacy of up to 97.1%, and a cure rate of up to 77.1%, indicating that the stone-promoting external-use medicine provided by the present invention has a good therapeutic effect.

[0037] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any appropriate manner without contradiction. In order to avoid unnecessary repetition, the present invention will not further describe various possible combinations.

[0038] In addition, the various embodiments of the present invention may be arbitrarily combined, and as long as they do not violate the concept of the present invention, they should also be regarded as the contents disclosed by the present invention.

Claims

1. A medicine for promoting the excretion of urinary stones, characterized in that: The preparation method is prepared from the following raw materials in parts by weight: 3-6 parts of yellow ochre, 2-4 parts of black pepper, 3-6 parts of sodium sulfate and 3-6 parts of alum.

2. The external medicine for promoting the excretion of urinary stones according to claim 1, characterized in that The product is prepared from the following raw materials in parts by weight: 4.5 parts of yellow lead, 3 parts of black pepper, 4.5 parts of sodium sulfate and 4.5 parts of alum.

3. The external medicine for promoting the excretion of urinary stones according to claim 1, characterized in that The external medicine for promoting the excretion of urinary stones is stored in a light-proof and heat-insulated manner.

4. The external medicine for promoting the excretion of urinary stones according to claim 3, characterized in that The external medicine for promoting the excretion of urinary stones is stored in a vacuum-sealed manner at room temperature.

5. The external medicine for promoting the excretion of urinary stones according to claim 1, characterized in that: The method of use is external application. Before external application, the urinary stone excretion-promoting external medicine is mixed with aged vinegar to obtain a paste.

6. The external medicine for promoting the excretion of urinary stones according to claim 5, characterized in that: The external application site is the patient's urethral opening, and the application time is 2-3 hours.

7. The external medicine for promoting the excretion of urinary stones according to claim 6, characterized in that: For male patients, the usage includes the following: Pour the paste into the external compress bag, then insert the penis into the external compress bag. When inserting, turn back the foreskin to make the external compress bag in close contact with the urethral opening.

8. The external medicine for promoting the excretion of urinary stones according to claim 6, characterized in that: For female patients, the instructions include the following: Pour the paste into the center of the external compress, then stick the external compress on the urethral opening. When sticking it in, pull apart the labia majora to make the external compress in close contact with the urethral opening.

9. The external medicine for promoting the excretion of urinary stones according to claim 6, characterized in that: Before taking the medicine, the patient should sweat 10-30 minutes in advance. At the same time, the patient is prohibited from using air conditioning or fans before and after taking the medicine to avoid catching cold. After taking the medicine, let the body sweat naturally.

10. A method for preparing an external medicine for promoting the excretion of urinary stones, which is used to prepare the external medicine for promoting the excretion of urinary stones according to any one of claims 1 to 9, characterized in that: Weigh yellow ochre, black pepper, sodium sulfate and alum by weight, grind each raw material separately until it is powdered, mix the powdered raw materials to obtain a mixed powder, that is, an external medicine for promoting the excretion of urinary stones.