Composition of poppy seed oil, shiny-leaved yellowhorn oil and cistanche water extract for treating Alzheimer's disease and application of composition

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a poppy seed oil, shiny-leaved yellowhorn oil and cistanche water extract composition for treating Alzheimer's disease and application of the poppy seed oil, shiny-leaved yellowhorn oil and cistanche water extract composition. The poppy seed oil, shiny-leaved yellowhorn oil and cistanche water extract composition provided by the invention shows a remarkable treatment effect on the Alzheimer's disease in a caenorhabditis elegans obesity pathological model, can remarkably reduce the paralysis proportion of human-derived A beta protein transgenic caenorhabditis elegans, has the potential of treating the Alzheimer's disease, and can be used for treating the Alzheimer's disease. The compound can be applied to preparation of medicines for treating the Alzheimer's disease, and has a wide application prospect.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a composition of royal rice oil, Xanthoceras sorbifolia oil and Cistanche deserticola water extract for treating Alzheimer's disease and application thereof. Background Art

[0002] As a rare new resource agricultural product of state-controlled level, Royal Rice Oil contains polyunsaturated fatty acids, tocopherols and other nutritional and health ingredients that are beneficial to the human body, and has antioxidant effects. 1 Xanthoceras sorbifolia oil has significant effects in anti-inflammatory, antioxidant, etc. [2] At the same time, studies have shown that Xanthoceras sorbifolia oil has the effects of neuroprotection, improving memory, and improving Alzheimer's disease. 3 Cistanche deserticola has the effects of anti-oxidation, anti-apoptosis, anti-aging, and improving learning and memory abilities. 4 ].

[0003] Alzheimer's disease is a progressive neurodegenerative disease that mainly affects the elderly and is the most common type of dementia. The disease is characterized by the loss of neurons in the brain, leading to memory loss, cognitive dysfunction and behavioral changes, which ultimately affect the patient's daily life and work ability. The exact cause of Alzheimer's disease is not yet fully understood, but studies have shown that it may be related to genetics, environmental factors, lifestyle and abnormal accumulation of beta-amyloid protein (Aβ), Tau protein and oxidative stress in the brain. [5] In 2021, the number of people with Alzheimer's disease and other dementias in the world reached 57,010,854 (49,508,597 to 65,155,679 cases), of which 16,990,827 (14,488,494 to 19,672,741) were in my country, accounting for about 29.8% of the global total. [6] .

[0004] Currently, the drugs that have been marketed in China for improving cognitive symptoms of Alzheimer's disease include cholinesterase inhibitors [donepezil, rivastigmine (rivastigmine), galantamine, and huperzine A], N-methyl-D-aspartate (NMDA) receptor antagonists (memantine hydrochloride), ginkgo biloba extract tablets, and mannitol sodium capsules [ 7 These drugs can only slow down the progression of the disease to a certain extent, but cannot effectively prevent or reverse the disease process. [5] , and has side effects such as nausea, headache, dizziness, gastrointestinal side effects, etc.[ 8]. More and more evidence shows that oxidative stress may be one of the key factors in cognitive aging and the induction of Alzheimer's disease. In response to this phenomenon, improving the ability to resist oxidative stress and clearing Aβ aggregates may be more critical for the treatment of Alzheimer's disease. 9 ].

[0005] Abnormal deposition of Aβ blocks neurotransmitter transmission, leading to synaptic dysfunction and neuronal loss, and forming senile plaques in the brains of Alzheimer's patients. The nematode model simulates Aβ neural damage by expressing human Aβ1-40 or Aβ1-42 genes. The role of Aβ oligomers in Alzheimer's disease and its study in the nematode model help to understand the pathogenesis of Alzheimer's disease. The present invention uses the Caenorhabditis elegans Alzheimer's disease model to discover anti-Alzheimer's drug candidates. 10 ].

[0006] Based on the above research status, the present invention now provides a composition of royal rice oil, Xanthoceras sorbifolia oil, and Cistanche deserticola water extract for the treatment of Alzheimer's disease. The composition shows significant therapeutic effects in a Caenorhabditis elegans Alzheimer's disease pathological model, can significantly reduce the paralysis rate of human Aβ protein transgenic Caenorhabditis elegans, has the potential to treat Alzheimer's disease, and can be used in the preparation of drugs for the treatment of Alzheimer's disease.

[0007] References

[0008] [1] Lu Bin, Tong Hongmei, Yang Jiawei. Research progress on the nutritional efficacy of royal rice oil[J]. Food Safety Guide, 2023, (21): 112-4+26.

[0009] [2] Gao Weiwei, Liu Min. Research progress on nutritional components and functional activities of Xanthoceras sorbifolia oil[J]. China Food Industry, 2024, (09): 171-3.

[0010] [3] Chen Ziyi. Revealing the mechanism of action of Xanthoceras sorbifolia oil in improving Alzheimer's disease based on multi-omics technology[D], 2024.

[0011] [4] Wang Lu, Wu Li'e, Jia Jianxin. Pharmacological effects of Cistanche deserticola and its research progress in central nervous system diseases[J]. Chinese Journal of Traditional Chinese Medicine, 2024, 42(03): 50-4.

[0012] [5]SCHELTENSP,DESTROOPERB,KIVIPELTOM,etal.Alzheimer'sdisease[J].Lancet,2021,397(10284):1577-90.

[0013] [6] Wang Gang, Qi Jinlei, Liu Xinya, et al. China Alzheimer's Disease Report 2024[J]. Diagnostics Theory and Practice, 2024, 23(03): 219-56.

[0014] [7] Ren Rujing, Yin Peng, Wang Zhihui, et al. China Alzheimer's Disease Report 2021[J]. Diagnostics Theory and Practice, 2021, 20(04): 317-37.

[0015] [8]FARLOWMR,MILLERML,PEJOVICV.Treatmentoptions in Alzheimer'sdisease:maximizingbenefit,managingexpectations[J].DementGeriatrCognDisord,2008,25(5):408-22.

[0016] [9] Wang Zhun, Sun Yuying, Huang Hanchang. Pathological relationship between oxidative stress and Alzheimer's disease and intervention measures[J]. Life Science, 2023, 35(04): 519-28.

[0017]

[10] Tang Xiaoli, Yang Yi, Liu Yue, et al. Application of Caenorhabditis elegans model in Alzheimer's disease research [J]. Chinese Pharmacological Bulletin, 2020, 36(03): 317-21. Summary of the Invention

[0018] In response to the above technical problems, the present invention aims to provide a composition of royal rice oil, Xanthoceras sorbifolia oil, and Cistanche deserticola water extract for treating Alzheimer's disease and its application. Specifically, it includes the following contents:

[0019] In a first aspect, the present invention provides a composition for treating Alzheimer's disease, wherein the active ingredients of the composition include royal rice oil and Xanthoceras sorbifolia oil.

[0020] Preferably, the mass ratio of the royal rice oil to the Xanthoceras sorbifolia oil is 1:1.

[0021] Preferably, the composition is a solution of royal rice oil and Xanthoceras sorbifolia oil dissolved in Tween 80.

[0022] Preferably, the present invention conducts experiments using a Caenorhabditis elegans Alzheimer's disease pathological model, and the preferred final concentrations of the rice oil and Xanthoceras sorbifolia oil in the rice oil and Xanthoceras sorbifolia oil solution are 0.01-10 mg / mL.

[0023] Preferably, the optimal final concentration of royal rice oil and Xanthoceras sorbifolia oil in the royal rice oil and Xanthoceras sorbifolia oil solution is 0.1 mg / mL.

[0024] Preferably, the active ingredient of the composition further includes a water extract of Cistanche deserticola.

[0025] Preferably, the mass ratio of the royal rice oil, Xanthoceras sorbifolia oil and Cistanche deserticola water extract is 1-10:1-10:10.

[0026] Preferably, the composition consists of rice oil and Xanthoceras sorbifolia oil solution dissolved in Tween 80 and Cistanche deserticola water extract.

[0027] Preferably, the ratio of the royal rice oil and Xanthoceras sorbifolia oil solution dissolved by Tween 80 to the Cistanche deserticola water extract is 1-10:5.

[0028] Preferably, the present invention conducts experiments using a Caenorhabditis elegans Alzheimer's disease pathological model, and the final concentrations of the rice oil and Xanthoceras sorbifolia oil in the rice oil and Xanthoceras sorbifolia oil solution are 0.01-10 mg / mL, and the final concentration of the Cistanche deserticola water extract is 0.05 mg / mL.

[0029] Preferably, the final concentration of the royal rice oil and the Xanthoceras sorbifolia oil in the royal rice oil and Xanthoceras sorbifolia oil solution is 0.1-10 mg / mL, and the final concentration of the Cistanche deserticola water extract is 0.05 mg / mL.

[0030] In a second aspect, the present invention provides use of the composition described in the first aspect in preparing a drug for preventing or treating Alzheimer's disease.

[0031] Preferably, the composition is added with pharmaceutically acceptable carriers / excipients to prepare any pharmaceutically acceptable dosage form.

[0032] Preferably, the dosage form is selected from any one of powder, granule, powder, pill, tablet, capsule, and oral liquid.

[0033] The present invention provides a composition of royal rice oil, Xanthoceras sorbifolia oil, and Cistanche deserticola water extract for treating Alzheimer's disease, and experiments are conducted on a Caenorhabditis elegans Alzheimer's disease pathological model, demonstrating that the composition described in the present application has a significant therapeutic effect on the Caenorhabditis elegans Alzheimer's disease pathological model: (1) Compared with royal rice oil and Xanthoceras sorbifolia oil as single herbs, the royal rice oil and Xanthoceras sorbifolia oil composition described in the present application has a significant therapeutic effect on the Caenorhabditis elegans Alzheimer's disease pathological model; (2) Compared with royal rice oil, Xanthoceras sorbifolia oil, and Cistanche deserticola water extract as single herbs, the royal rice oil, Xanthoceras sorbifolia oil, and Cistanche deserticola water extract composition described in the present application has a significant therapeutic effect on the Caenorhabditis elegans Alzheimer's disease pathological model; (3) Compared with the royal rice oil and Xanthoceras sorbifolia oil composition, the royal rice oil, Xanthoceras sorbifolia oil, and Cistanche deserticola water extract composition described in the present application has a significant therapeutic effect on the Caenorhabditis elegans Alzheimer's disease pathological model. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] Figure 1 The therapeutic effect of royal rice oil, Xanthoceras sorbifolia oil, and Cistanche deserticola water extract composition on Alzheimer's disease nematodes; wherein, Ctrl-blank control group; MJG-positive drug memantine hydrochloride group; 0.01Y+W+R-a combination of royal rice oil and Xanthoceras sorbifolia oil with a final concentration of 0.01 mg / mL and a Cistanche deserticola water extract composition group with a final concentration of 0.05 mg / mL; 0.1Y+W+R-a combination of royal rice oil and Xanthoceras sorbifolia oil with a final concentration of 0.1 mg / mL and a Cistanche deserticola water extract composition group with a final concentration of 0.05 mg / mL; 1Y+W+R-a combination of royal rice oil and Xanthoceras sorbifolia oil with a final concentration of 1 mg / mL and a Cistanche deserticola water extract composition group with a final concentration of 0.05 mg / mL; 10Y+W+R-a combination of royal rice oil and Xanthoceras sorbifolia oil with a final concentration of 10 mg / mL and a Cistanche deserticola water extract composition group with a final concentration of 0.05 mg / mL;

[0035] Figure 2 Comparison of the therapeutic effects of royal rice oil and Xanthoceras sorbifolia oil on Alzheimer's disease nematodes; Ctrl-blank control group; MJG-positive drug memantine hydrochloride group; 0.01RCR-final concentration of 0.01mg / mL Cistanche deserticola water extract group; 0.01YMY-final concentration of 0.01mg / mL royal rice oil group; 0.1YMY-final concentration of 0.1mg / mL royal rice oil group; 1YMY-final concentration of 1mg / mL royal rice oil group; 0.01WGGY-final concentration of 0.01mg / mL Xanthoceras sorbifolia oil group; 0.1WGGY-final concentration of 0.1mg / mL Xanthoceras sorbifolia oil group; 1WGGY-final concentration of 1mg / mL Xanthoceras sorbifolia oil group;

[0036] Figure 3 The therapeutic effect of the combination of royal rice oil and Xanthoceras sorbifolia oil on Alzheimer's nematodes; among them, Ctrl-blank control group; MJG-positive drug memantine hydrochloride group; 0.01Y+W-royal rice oil and Xanthoceras sorbifolia oil group with a final concentration of 0.01 mg / mL and group; 0.1Y+W-royal rice oil and Xanthoceras sorbifolia oil group with a final concentration of 0.1 mg / mL and group. DETAILED DESCRIPTION

[0037] Example 1 Preparation method of royal rice oil, Xanthoceras sorbifolia oil, and Cistanche deserticola water extract composition

[0038] YMY: Weigh 1 mass fraction of YMY, add 1 times the amount of Tween 80, vortex mix, filter and sterilize, and set aside.

[0039] Xanthoceras sorbifolia oil (WGGY): Weigh 1 mass fraction of Xanthoceras sorbifolia oil, add 1 times the amount of Tween 80, vortex to mix, filter and sterilize, and set aside.

[0040] Cistanche deserticola water extract (RCR): Weigh 1 mass fraction of Cistanche deserticola powder, add 6 times the amount of distilled water, heat and reflux in a condenser reflux apparatus for 1 hour, repeat twice, filter and take the supernatant solution for later use; combine the two supernatants and concentrate the solution using a rotary evaporator, then freeze the concentrated solution in a -80℃ refrigerator for 24 hours, place it in a freeze dryer for freeze drying, collect the freeze-dried powder, and store it at -20℃ for later use.

[0041] Preparation of Cistanche deserticola aqueous extract solution: 0.05 g of Cistanche deserticola aqueous extract freeze-dried powder was added with distilled water to make up to 1 mL, filtered and sterilized, and set aside.

[0042] Royal rice oil and Xanthoceras sorbifolia oil composition (Y+W): Weigh 1 mass part of royal rice oil and 1 mass part of Xanthoceras sorbifolia oil, add 2 times the amount of Tween 80, vortex mix, filter and sterilize, and set aside.

[0043] Composition of royal rice oil, Xanthoceras sorbifolia oil and Cistanche deserticola water extract (Y+W+R): Combine the royal rice oil and Xanthoceras sorbifolia oil composition and the Cistanche deserticola water extract liquid to form a composition.

[0044] Example 2 Therapeutic Effect of a Composition of Royal Rice Oil, Xanthoceras sorbifolia Oil, and Cistanche Deserticola Water Extract on Alzheimer's Nematodes 1. Biomaterials:

[0045] (1) The wild-type Caenorhabditis elegans strain CL4176 was purchased from the Caenorhabditis Genetics Center (CGC);

[0046] (2) Escherichia coli OP50 (uracil leaky mutant), purchased from Caenorhabditis Genetics Center (CGC), was used as food for Caenorhabditis elegans.

[0047] 2. Reagents

[0048] (1) Solid NGM (Nematode Growth Medium) culture medium composition and preparation (taking 1 L as an example), the composition is shown in Table 1:

[0049] Table 1 Composition of solid NGM medium

[0050] Element content NaCl 3.00g <![CDATA[K2HPO4]]> 2.34g <![CDATA[KH2PO4]]> 17.23g Peptone 2.50g agar 17.00g <![CDATA[Add H2O to]]> 1000mL

[0051] After preparing solid NGM medium, autoclave at 121°C for 20 minutes. Under a sterile operating table, add 1 mL of 5 mg / mL cholesterol-ethanol solution, 1 mL of 1 M MgSO₄, and 1 mL of 1 M CaCl₂, shake well, and pour into sterilized 9 cm culture plates while still hot, approximately 20 mL per plate. Let the medium stand until it solidifies and set aside.

[0052] (2) The formula of M9 liquid is shown in Table 2.

[0053] Table 2M9 liquid formula

[0054] Element content <![CDATA[Na2HPO4]]> 6.00g <![CDATA[KH2PO4]]> 3.00g NaCl 5.00g <![CDATA[1MMgSO4]]> 1.00mL <![CDATA[Add H2O to]]> 1000mL

[0055] (3) Preparation of lysis buffer: 6.4% NaClO solution and 1 M NaOH solution were mixed in a volume ratio of 1:1.

[0056] 3. Preparation of NGM plates containing rice oil, Xanthoceras sorbifolia oil, and Cistanche deserticola water extract

[0057] Preparation of Cistanche deserticola aqueous extract solution: 0.05 g of Cistanche deserticola aqueous extract freeze-dried powder was added with distilled water to make up to 1 mL, filtered and sterilized, and set aside.

[0058] Prepare NGM plates containing royal rice oil, Xanthoceras sorbifolia oil, and Cistanche deserticola water extract: take a Cistanche deserticola water extract solution of appropriate dilution and royal rice oil and Xanthoceras sorbifolia oil dissolved in Tween 80, add them to NGM culture medium, and pour the plates.

[0059] The final concentrations of the combination of royal rice oil and Xanthoceras sorbifolia oil (Y+W) were 0.01 mg / mL, 0.1 mg / mL, 1 mg / mL, and 10 mg / mL, respectively, at 100-fold, 1000-fold, 10,000-fold, and 100,000-fold dilutions of the initial preparation solution.

[0060] The final concentration of the Cistanche deserticola water extract (R) was 1000-fold diluted from the initial prepared solution, resulting in a final concentration of 0.01 mg / mL;

[0061] The combination of royal rice oil, Xanthoceras sorbifolia oil and Cistanche deserticola water extract (Y+W+R) is prepared by adding Cistanche deserticola water extract with a final concentration of 0.05 mg / mL to the combination of royal rice oil and Xanthoceras sorbifolia oil.

[0062] The culture medium was allowed to solidify and evenly spread with E. coli OP50 on the culture medium as food for the nematodes.

[0063] 4. Implementation steps

[0064] (1) Cultivation of nematodes:

[0065] The nematodes were plated on solid NGM plates coated with Escherichia coli OP50 and then cultured in an incubator at 15°C. When the nematodes grew into adults, they were synchronized.

[0066] (2) Synchronization of nematodes:

[0067] Select an NGM culture medium containing a large number of adult nematodes and some hatched eggs. Wash the nematodes off the culture medium with M9 solution and transfer them to a centrifuge tube. Allow the nematodes to settle to the bottom of the tube and discard the supernatant. Add lysis buffer to the centrifuge tube depending on the number of nematodes. Vortex the tube for 5-7 minutes until all nematodes are broken. Discontinue vortexing and aliquot into 1.5 mL centrifuge tubes. Wash the eggs three times with M9 solution.

[0068] (3) Experimental group settings:

[0069] The blank control group (Ctrl); the positive drug memantine hydrochloride group (MJG, 50 μM); the combination groups of royal rice oil, Xanthoceras sorbifolia oil, and Cistanche deserticola water extract (0.01Y+W+R, 0.1Y+W+R, 01Y+W+R, 10Y+W+R), wherein 0.01Y+W+R consisted of a combination of royal rice oil and Xanthoceras sorbifolia oil (Y+W) with a final concentration of 0.01 mg / mL and 0.05 mg / mL of Cistanche deserticola water extract; 0.1Y+W +R consists of a combination of royal rice oil and Xanthoceras sorbifolia oil (Y+W) with a final concentration of 0.1 mg / mL and 0.05 mg / mL of Cistanche deserticola water extract; 1Y+W+R consists of a combination of royal rice oil and Xanthoceras sorbifolia oil (Y+W) with a final concentration of 1 mg / mL and 0.05 mg / mL of Cistanche deserticola water extract; 10Y+W+R consists of a combination of royal rice oil and Xanthoceras sorbifolia oil (Y+W) with a final concentration of 10 mg / mL and 0.05 mg / mL of Cistanche deserticola water extract.

[0070] (4) Therapeutic effect of a combination of royal rice oil, Xanthoceras sorbifolia oil, and Cistanche deserticola water extract on a Caenorhabditis elegans Alzheimer's disease model

[0071] Nematode drug treatment: The hatched L1 nematodes were transferred to NGM plates coated with OP50 and mixed with different concentrations of royal rice oil, Xanthoceras sorbifolia oil, and Cistanche deserticola water extract. 60-80 nematodes were plated on each plate. After incubation at 15°C for 40 hours, the plates were transferred to 25°C for 32 hours. The non-paralysis rate was recorded every 2 hours for 10 hours.

[0072] Data processing and statistical analysis: SPSS 23.0 statistical software was used for data processing. Data are presented as mean ± standard deviation (mean ± SD). Data were analyzed using one-way ANOVA, with Tukey's test for significant differences. P < 0.05 indicated statistical significance. Statistical graphs were generated using GraphPad Prism 9.5.0 software.

[0073] (5) Experimental results

[0074] The results are as follows Figure 1As shown, compared with the positive drug memantine hydrochloride group (MJG), the royal rice oil, Xanthoceras sorbifolia oil, and Cistanche deserticola water extract composition described in the present application has a significant therapeutic effect on the Caenorhabditis elegans Alzheimer's disease pathological model.

[0075] Example 3 Comparison of the therapeutic effects of royal rice oil and Xanthoceras sorbifolia oil on Alzheimer's disease nematodes

[0076] Verification of the therapeutic effects of royal rice oil, Xanthoceras sorbifolia oil, and Cistanche deserticola water extract on the Caenorhabditis elegans Alzheimer's disease model:

[0077] 1. Experimental Group Setup

[0078] Blank control group (Ctrl); positive drug memantine hydrochloride group (MJG, 50μM); royal rice oil group (0.01-1YMY, indicating royal rice oil with a final concentration of 0.01mg / mL, 0.1mg / mL royal rice oil, and 1mg / mL royal rice oil, respectively); Xanthoceras sorbifolia oil group (0.01-1WGGY, indicating Xanthoceras sorbifolia oil with a final concentration of 0.01mg / mL, 0.1mg / mL, and 1mg / mL Xanthoceras sorbifolia oil, respectively); Cistanche deserticola water extract (0.01RCR, indicating Cistanche deserticola water extract with a final concentration of 0.01mg / mL).

[0079] 2. Experimental Procedure

[0080] The specific implementation steps are the same as those in Example 2.

[0081] 3. Experimental Results

[0082] The experimental results are as follows Figure 2 As shown in the results: compared with the blank, royal rice oil and Xanthoceras sorbifolia oil alone had no therapeutic effect on the Alzheimer's disease pathological model of Caenorhabditis elegans; compared with the positive drug memantine hydrochloride, the Cistanche deserticola water extract alone had a poor therapeutic effect on the Alzheimer's disease pathological model of Caenorhabditis elegans.

[0083] Compared with Example 2, the composition of royal rice oil, Xanthoceras sorbifolia oil and Cistanche deserticola water extract described in this application has a significant therapeutic effect on Alzheimer's disease

[0084] Example 4 Therapeutic Effect of the Composition of Royal Rice Oil and Xanthoceras sorbifolia Oil on Alzheimer's Nematodes

[0085] 1. Experimental Group Setup

[0086] Blank control group (Ctrl); positive drug memantine hydrochloride group (MJG, 50μM); royal rice oil and Xanthoceras sorbifolia oil combination group (0.01Y+W, 0.1Y+W), among which 0.01Y+W is a combination of royal rice oil and Xanthoceras sorbifolia oil (Y+W) with a final concentration of 0.01 mg / mL; 0.1Y+W is a combination of royal rice oil and Xanthoceras sorbifolia oil (Y+W) with a final concentration of 0.1 mg / mL.

[0087] 2. Experimental Procedure

[0088] Same as Example 2.

[0089] 3. Experimental Results

[0090] The experimental results are as follows Figure 3 As shown in the figure: compared with the blank group and the positive control group, the royal rice oil and Xanthoceras sorbifolia oil composition described in the present application has a significant therapeutic effect on the Caenorhabditis elegans Alzheimer's disease pathological model; and Figure 1 In comparison, the combination of royal rice oil, Xanthoceras sorbifolia oil, and Cistanche deserticola water extract described in the present application has a more significant therapeutic effect on the Caenorhabditis elegans Alzheimer's disease pathological model.

[0091] The results of the above examples show that the combination of royal rice oil, Xanthoceras sorbifolia oil, and the combination of royal rice oil, Xanthoceras sorbifolia oil, and Cistanche deserticola water extract can significantly reduce the paralysis rate of human Aβ protein transgenic Caenorhabditis elegans, and have a significant therapeutic effect on the Caenorhabditis elegans Alzheimer's disease pathological model. This shows that the combination of royal rice oil, Xanthoceras sorbifolia oil, and Cistanche deserticola water extract has the potential to treat Alzheimer's disease, can be used in the preparation of drugs for treating Alzheimer's disease, and can also be used in the preparation of health products for the prevention and auxiliary treatment of Alzheimer's disease. It is expected to be developed into a new generation of drugs for treating Alzheimer's disease or health products for preventing Alzheimer's disease.

Claims

1. A composition for treating Alzheimer's disease, characterized in that: The active ingredients of the composition include royal rice oil and Xanthoceras sorbifolia oil.

2. The composition according to claim 1, wherein The mass ratio of the royal rice oil to the Xanthoceras sorbifolia oil is 1:

1.

3. The composition according to claim 2, wherein The composition is a solution of royal rice oil and Xanthoceras sorbifolia oil dissolved in Tween 80.

4. The composition according to claim 1, wherein The active ingredient of the composition also includes a water extract of Cistanche deserticola.

5. The composition according to claim 4, wherein The mass ratio of the royal rice oil, Xanthoceras sorbifolia oil and Cistanche deserticola water extract is 1-10:1-10:

10.

6. The composition according to claim 5, wherein The composition consists of rice oil dissolved in Tween 80, Xanthoceras sorbifolia oil solution and Cistanche deserticola water extract.

7. The composition according to claim 6, wherein The ratio of the rice oil and Xanthoceras sorbifolia oil solution dissolved by Tween 80 to the Cistanche deserticola water extract is 1-10:

5.

8. Use of the composition according to any one of claims 1 to 7 in the preparation of a medicament for preventing or treating Alzheimer's disease.

9. The use according to claim 8, characterized in that The composition is added with pharmaceutically acceptable carriers / excipients to prepare any pharmaceutically acceptable dosage form.

10. The use according to claim 9, characterized in that The dosage form is selected from any one of powder, granule, powder, pill, tablet, capsule and oral solution.

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