Traditional Chinese medicine formula for treating chronic intractable stomach disease and application of traditional Chinese medicine formula

Abstract

The invention discloses a traditional Chinese medicine formula for treating chronic intractable stomach diseases and application thereof. A compound preparation is prepared from the following traditional Chinese medicine raw materials in parts by mass: 30-35g of fried endothelium corneum gigeriae galli, 20-25g of cuttlebone, 20-25g of fried malt, 20-25g of fried hawthorn, 15-20g of astragalus membranaceus, 20-25g of bletilla striata and 12-15g of pseudo-ginseng. The traditional Chinese medicine formula takes genuine traditional Chinese medicinal materials as raw materials, is definite in components, controllable in quality, exact in clinical curative effect, relatively small in toxic and side effects and suitable for clinical popularization. The traditional Chinese medicine compound is in a powder form, is prepared by the steps of cleaning, selecting, drying, sterilizing, crushing and the like, is low in preparation process cost, can ensure that effective components are dissolved out, is suitable for large-scale production, and is convenient to take, carry and store. The traditional Chinese medicine compound powder is orally taken, decoction is avoided, time is saved, and medication convenience is also increased for the old, children, patients difficult to swallow the whole tablet of medicine and the like.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine formulas, in particular to a traditional Chinese medicine formula for treating chronic intractable gastropathy and application thereof. Background Art

[0002] Persistent stomach problems may be related to Helicobacter pylori infection, chronic gastritis, peptic ulcer, functional dyspepsia, or gastric cancer. Currently, the main clinical treatments for intractable stomach problems include dietary adjustments and medication. Different types of stomach problems require different treatments with Chinese and Western medicine. While Western medicine is effective quickly, it has a high recurrence rate after discontinuation, and long-term use can easily lead to drug resistance. Traditional Chinese Medicine offers unique advantages in treating intractable gastrointestinal diseases, with minimal side effects and a high safety profile. Prescriptions can be tailored to the patient's specific symptoms, signs, and syndrome differentiation.

[0003] Currently, most traditional Chinese medicine treatments are decoctions, and the processing of medicinal materials is relatively cumbersome, which greatly reduces patient compliance and reduces efficacy. Because the preparation method and compatibility of traditional Chinese medicines can affect their efficacy, the present invention provides a safe and effective new traditional Chinese medicine formula and its use instructions, which are of great significance for the treatment of intractable gastritis. Summary of the Invention

[0004] The purpose of the present invention is to provide a traditional Chinese medicine formula for treating chronic intractable gastropathy and its application, so as to solve the problems raised in the above background technology.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a traditional Chinese medicine formula for treating chronic intractable gastropathy, wherein the compound preparation is prepared from the following traditional Chinese medicine raw materials in the following parts by weight: 30-35 grams of stir-fried chicken gizzard lining, 20-25 grams of cuttlebone, 20-25 grams of stir-fried malt, 20-25 grams of stir-fried hawthorn, 15-20 grams of astragalus, 20-25 grams of white hyacinth and 12-15 grams of Panax notoginseng.

[0006] Preferably, the compound preparation is prepared from the following Chinese medicinal raw materials in the following parts by mass: 30 grams of fried chicken gizzard lining, 22 grams of cuttlebone, 20 grams of fried malt, 22 grams of fried hawthorn, 20 grams of astragalus, 24 grams of white hyacinth and 12 grams of Panax notoginseng.

[0007] Preferably, the compound preparation is prepared with the following parts by mass of Chinese medicinal raw materials: 35 grams of fried chicken gizzard lining, 20 grams of cuttlebone, 25 grams of fried malt, 20 grams of fried hawthorn, 18 grams of astragalus, 22 grams of white hyacinth and 15 grams of Panax notoginseng.

[0008] Preferably, the preparation is an oral preparation.

[0009] Preferably, the method for preparing the oral preparation comprises the following steps:

[0010] Step 1: Select the herbs: Choose authentic stir-fried chicken gizzard lining, cuttlebone, stir-fried malt, stir-fried hawthorn, astragalus root, white hyacinth root, and Panax notoginseng;

[0011] Step 2: Processing: Stir-fry chicken gizzard lining, malt, and hawthorn at 100°C until slightly yellow, and stir-fry cuttlebone at 80°C for 10 minutes.

[0012] Step 3: Crushing and sterilization: ultrafine grinding, passing through a 200-mesh sieve, and sterilizing by 60Co-γ ray irradiation at a dose of 5-10 kGy;

[0013] Step 4: Formulation: Divide into 6-7g / bag and seal with aluminum foil.

[0014] Preferably, the oral preparation is taken in an amount of 6-7 grams each time, and is taken three times a day with 40-50° warm water.

[0015] Application of a traditional Chinese medicine formula for treating chronic intractable gastropathy in medicine for treating chronic intractable gastropathy.

[0016] Compared with the prior art, the present invention has the following beneficial effects:

[0017] The traditional Chinese medicine formula of the present invention uses authentic traditional Chinese medicine as raw materials, has clear ingredients and controllable quality, definite clinical efficacy, relatively small toxic and side effects, and is suitable for clinical promotion.

[0018] The traditional Chinese medicine compound of the present invention is in the form of powder and is prepared through the steps of cleaning, drying, sterilizing, pulverizing and the like. The preparation process has low cost, can ensure the dissolution of effective ingredients, is suitable for large-scale production, and is easy to take, carry and store.

[0019] The present invention selects the Chinese medicine compound powder for oral administration, avoids decocting, saves time, and increases the convenience of medication for the elderly, children, and patients who have difficulty swallowing whole tablets.

[0020] The powder form adopted by the traditional Chinese medicine formula of the present invention can better individualize the medication, flexibly prepare it according to the needs of different patients, and add or subtract it according to the symptoms.

[0021] The traditional Chinese medicine formula of the present invention adopts the powder form, and the absorption rate of some medicinal materials is greatly improved after being crushed, which can better exert the medicinal effect and thus reduce the waste of medicinal materials.

[0022] The traditional Chinese medicine formula of the present invention is prepared by reasonable combination of medicinal materials and powder, and then stir-fried, so as to reduce toxicity, improve heat-clearing effect, and have the effects of replenishing qi and strengthening the exterior. DETAILED DESCRIPTION

[0023] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0024] The invention provides a traditional Chinese medicine formula for treating chronic intractable gastropathy. The compound preparation is prepared from the following traditional Chinese medicine raw materials in parts by weight: 30-35 grams of stir-fried chicken gizzard lining, 20-25 grams of cuttlebone, 20-25 grams of stir-fried malt, 20-25 grams of stir-fried hawthorn, 15-20 grams of astragalus, 20-25 grams of bletilla striata and 12-15 grams of notoginseng.

[0025] Stir-fried Chicken Gizzard Neck is the dried inner wall of the gizzard of the domesticated chicken (Phasianidae). It is sweet and neutral in nature. It stimulates gastric secretion and enhances digestion, and is used to treat indigestion and malnutrition in children. The Southern Yunnan Materia Medica records that Chicken Gizzard Neck can soothe stomachaches, strengthen the spleen, and aid digestion. Modern research confirms that it contains gastric hormones and keratin, which regulate gastrointestinal motility and emptying. Grinding it into a powder is more effective than a decoction.

[0026] Cuttlebone is the dried inner shell of the needleless or golden cuttlefish, both members of the family Sepia. It has a salty, astringent flavor and warm properties. It has astringent, hemostatic, analgesic, and sore-resolving properties. It also contains calcium carbonate, which can effectively relieve stomach pain and acid reflux and promote ulcer healing.

[0027] Roasted barley malt is mainly used to treat indigestion, abdominal distension and pain, and poor appetite due to spleen deficiency. It has the effects of promoting qi and digestion, strengthening the spleen and appetite, stimulating gastric juice secretion, strengthening spleen and stomach function, increasing appetite, and helping to improve the body's digestion and absorption capacity.

[0028] Stir-fried hawthorn is a good remedy for strengthening the spleen and appetite, relieving food stagnation, and promoting blood circulation and resolving phlegm. Certain compounds in hawthorn have antimicrobial activity, inhibiting bacteria such as Helicobacter pylori that cause stomach problems. The flavonoids in hawthorn also have analgesic properties, helping to relieve stomach pain and providing some relief from pain caused by gastritis and gastric ulcers.

[0029] According to the Chinese Pharmacopoeia, Astragalus is mainly used to: "tonify Qi and raise Yang, consolidate the exterior and stop sweating, promote the production of body fluids and nourish blood. It is used for Qi deficiency and fatigue, poor appetite and loose stools, sinking of Qi in the middle, spontaneous sweating due to exterior deficiency, edema due to Qi deficiency, internal heat and thirst, and sallow complexion due to blood deficiency." Astragalus helps to enhance the body's immunity and promote the repair of gastrointestinal mucosa, and has a positive effect on stomach problems.

[0030] The rhizome of Bletilla striata is used as a traditional Chinese medicine. It has a bitter taste, sweet, astringent properties, and a slightly cold nature. It enters the lung, stomach, and liver meridians, and has astringent, hemostatic, and tissue-stimulating properties. Pharmacological studies have confirmed that Bletilla striata contains a large amount of mucilage, which includes various polysaccharides, volatile oils, and starch. Adding fine Bletilla striata powder to water or boiling it produces a colloid-like liquid that has a potent hemostatic effect when applied topically to wounds. It shortens clotting time and inhibits fibrinolysis, allowing for the formation of artificial thrombi to stop bleeding. It also repairs capillary defects, promoting wound healing and growth.

[0031] Panax notoginseng is warm in nature, with a sweet and slightly bitter taste. It enters the liver and stomach meridians. It has the effects of nourishing blood, combating inflammation, and promoting blood circulation and removing blood stasis. It can help improve circulation in the digestive tract and promote the repair of the gastric mucosa. Panax notoginseng also has anti-inflammatory and analgesic properties, as well as spleen-tonifying and stomach-regulating properties. It can be used as an adjunct treatment for gastric ulcers, duodenal ulcers, and other stomach problems.

[0032] The preparation is an oral preparation.

[0033] The preparation method of the oral preparation comprises the following steps:

[0034] Step 1: Select the herbs: Choose authentic stir-fried chicken gizzard lining, cuttlebone, stir-fried malt, stir-fried hawthorn, astragalus root, white hyacinth root, and Panax notoginseng;

[0035] Step 2: Processing: Stir-fry chicken gizzard lining, malt, and hawthorn at 100°C until slightly yellow, and stir-fry cuttlebone at 80°C for 10 minutes.

[0036] Step 3: Crushing and sterilization: ultrafine grinding, passing through a 200-mesh sieve, and sterilizing by 60Co-γ ray irradiation at a dose of 5-10 kGy;

[0037] Step 4: Formulation: Divide into 6-7g / bag and seal with aluminum foil.

[0038] The dosage of oral preparation is 6-7 grams each time, and the dosage is three times a day, taken with 40-50° warm water.

[0039] Application of a traditional Chinese medicine formula for treating chronic intractable gastropathy in medicine for treating chronic intractable gastropathy.

[0040] Example 1:

[0041] Weigh the raw materials: Take 30g of chicken gizzard lining, 22g of cuttlebone, 20g of malt, 22g of hawthorn, 20g of astragalus, 24g of white hyacinth, and 12g of Panax notoginseng;

[0042] Processing: Stir-fry chicken gizzard lining, malt, and hawthorn at 100℃ for 15 minutes until the surface turns slightly yellow. Stir-fry cuttlebone at 80℃ for 10 minutes.

[0043] Crushing and sterilization: put into ultrafine grinder to crush to 200 mesh (pass rate ≥ 95%), and sterilize by 60Co-γ ray irradiation (dose 8kGy);

[0044] Packaging and molding: Pack 6g / bag, seal in aluminum foil bag to get the finished product.

[0045] Example 2:

[0046] Weigh the ingredients: Take 35g of chicken gizzard lining, 20g of cuttlebone, 25g of malt, 20g of hawthorn, 18g of astragalus, 22g of white hyacinth and 15g of Panax notoginseng;

[0047] Processing: Stir-fry chicken gizzard lining, malt, and hawthorn at 100℃ for 15 minutes until the surface turns slightly yellow. Stir-fry cuttlebone at 80℃ for 10 minutes.

[0048] Crushing and sterilization: put into ultrafine grinder to crush to 200 mesh (pass rate ≥ 95%), and sterilize by 60Co-γ ray irradiation (dose 8kGy);

[0049] Packaging and molding: Pack 7g / bag, seal in aluminum foil bag to get the finished product.

[0050] Clinical application cases

[0051] Patient: A 45-year-old male patient had recurrent stomach pain and acid reflux for 3 years. Endoscopy diagnosed him with chronic atrophic gastritis with gastric ulcer (0.8 cm in diameter).

[0052] Usage: 3 times a day, 6g each time, taken with 40℃ warm water, 30 minutes before meals, the course of treatment is 8 weeks.

[0053] Efficacy: Acid reflux disappeared after 2 weeks, stomach pain was relieved after 4 weeks, ulcer healed (diameter ≤ 0.3 cm) during gastroscopy after 8 weeks, gastric mucosal inflammation score decreased by 60%, and serum pepsinogen I (PG I) level rebounded by 25%.

[0054] The formula, using the aforementioned quantitative ratio, can be used to treat chronic, intractable gastritis and its complications, while also repairing gastric ulcer wounds and alleviating patient discomfort. Based on the degree of relief of the patient's clinical symptoms, the herbal ratio and dosage can be gradually adjusted to further repair the gastric mucosa and prevent recurrence.

[0055] Although the present invention has been described in detail with reference to the aforementioned embodiments, it is still possible for those skilled in the art to modify the technical solutions described in the aforementioned embodiments, or to make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A Chinese medicine formula for treating chronic intractable gastropathy, characterized by: The compound preparation is prepared with the following parts by mass of Chinese medicinal raw materials: 30-35 grams of fried chicken gizzard lining, 20-25 grams of cuttlebone, 20-25 grams of fried malt, 20-25 grams of fried hawthorn, 15-20 grams of astragalus, 20-25 grams of white hyacinth and 12-15 grams of Panax notoginseng.

2. A Chinese medicine formula for treating chronic intractable gastropathy according to claim 1, characterized in that: The compound preparation is prepared from the following Chinese medicinal raw materials in parts by weight: 30 grams of stir-fried chicken gizzard lining, 22 grams of cuttlebone, 20 grams of stir-fried malt, 22 grams of stir-fried hawthorn, 20 grams of astragalus, 24 grams of white hyacinth and 12 grams of Panax notoginseng.

3. A Chinese medicine formula for treating chronic intractable gastropathy according to claim 1, characterized in that: The compound preparation is prepared with the following parts by mass of Chinese medicinal raw materials: 35 grams of fried chicken gizzard lining, 20 grams of cuttlebone, 25 grams of fried malt, 20 grams of fried hawthorn, 18 grams of astragalus, 22 grams of white hyacinth and 15 grams of Panax notoginseng.

4. A Chinese medicine formula for treating chronic intractable gastropathy according to any one of claims 1 to 3, characterized in that: The preparation is an oral preparation.

5. A Chinese medicine formula for treating chronic intractable gastropathy according to any one of claim 4, characterized in that: The preparation method of the oral preparation comprises the following steps: Step 1: Select the herbs: Choose authentic stir-fried chicken gizzard lining, cuttlebone, stir-fried malt, stir-fried hawthorn, astragalus root, white hyacinth root, and Panax notoginseng; Step 2: Processing: Stir-fry chicken gizzard lining, malt, and hawthorn at 100°C until slightly yellow, and stir-fry cuttlebone at 80°C for 10 minutes. Step 3: Crushing and sterilization: ultrafine grinding, passing through a 200-mesh sieve, and sterilizing by 60Co-γ ray irradiation at a dose of 5-10 kGy; Step 4: Formulation: Divide into 6-7g / bag and seal with aluminum foil.

6. A Chinese medicine formula for treating chronic intractable gastropathy according to any one of claim 5, characterized in that: The oral preparation is taken in an amount of 6-7 grams each time, and is taken three times a day with 40-50° warm water.

7. Use of a traditional Chinese medicine formula for treating chronic intractable gastropathy according to any one of claims 1 to 6 in a medicine for treating chronic intractable gastropathy.