Probiotic ganoderma lucidum yeast tablet and production method thereof

Abstract

The invention relates to the technical field of medicine preparation, and provides a probiotic ganoderma lucidum yeast tablet which comprises 30-50% of ganoderma sinense extract; 20%-35% of yeast powder; 10%-25% of microcrystalline cellulose; 1%-3% of magnesium stearate; the content of polysaccharide in the ganoderma sinense extract is greater than or equal to 15%, the content of triterpenoids in the ganoderma sinense extract is greater than or equal to 8%, and the flavoring agent is selected from one or a combination of more of menthol, stevioside and citric acid. The probiotic ganoderma lucidum yeast tablet is rich in high-content ganoderma sinense extract and yeast powder, in the ganoderma sinense extract, polysaccharide regulates the immune function, enhances the body resistance and assists in gastric mucosa repair, triterpenoids have anti-inflammatory and antioxidant activity and effectively relieve symptoms of patients, the yeast powder can promote food digestion and absorption and improve the gastrointestinal function, and the health care effect is achieved. The main components of the product are all natural, the safety is high, and the toxic and side effects are greatly reduced compared with traditional chemical synthesis drugs.

Description

Technical Field

[0001] The present invention relates to the technical field of drug preparation, in particular to a probiotic ganoderma lucidum yeast tablet and a production method thereof. Background Art

[0002] Chronic gastrointestinal diseases such as gastritis, gastric ulcer, and reflux esophagitis have a high incidence rate and seriously affect the quality of life of patients. At present, these diseases are difficult to cure clinically. Conventional treatments can often only relieve symptoms but cannot fundamentally repair damaged gastrointestinal tissues. As the disease progresses, some patients may even develop malignant tumors, which brings heavy physical and mental burdens and financial pressures to patients.

[0003] Traditional therapeutic drugs have many limitations. Long-term use of drugs that inhibit gastric acid secretion may lead to insufficient gastric acid secretion, affecting food digestion and nutrient absorption, and may also increase the risk of intestinal infections. Although gastric mucosal protectants can protect the gastric mucosa to a certain extent, they have limited effects on repairing damaged mucosa, and some drugs may cause adverse reactions such as constipation. Gastrointestinal motility-promoting drugs may cause side effects such as abdominal pain and diarrhea, and are not effective in improving the root causes of the disease. In addition, these diseases are often prone to recurrence, and traditional treatment options are difficult to achieve a complete cure of the disease, causing long-term physical pain and economic burden to patients.

[0004] Therefore, the development of a drug or health food for treating chronic gastritis, gastric ulcer or reflux esophagitis with significant therapeutic effect and few side effects has important clinical significance and market demand. Summary of the Invention

[0005] In view of the shortcomings of the existing technology, the present invention provides a probiotic Ganoderma lucidum yeast tablet and a production method thereof, which solves the problems of poor therapeutic effect and side effects of the existing gastrointestinal drugs.

[0006] To achieve the above objectives, the present invention is implemented through the following technical scheme: probiotic Ganoderma lucidum yeast tablets, comprising the following components in weight percentage: purple Ganoderma lucidum extract: 30%-50%; yeast powder: 20%-35%; microcrystalline cellulose: 10%-25%; magnesium stearate: 1%-3%; flavoring agent: 0.5%-2%.

[0007] Preferably, the polysaccharide content in the purple Ganoderma lucidum extract is ≥15%, and the triterpenoid content is ≥8%.

[0008] Preferably, the flavoring agent is selected from one or more combinations of menthol, steviol glycoside or citric acid.

[0009] Preferably, the production method of probiotic Ganoderma lucidum yeast tablets comprises the following steps: S1. The dried purple Ganoderma lucidum was crushed to 80-100 mesh, 70%-90% ethanol was added at a material-liquid ratio of 1:10-1:15, and refluxed at 60-80 ° C for 2-3 times, each for 1-2 hours. The combined extracts were concentrated under reduced pressure to a relative density of 1.2-1.3 and dried to obtain a purple Ganoderma lucidum extract; S2. Weigh the purple Ganoderma lucidum extract, yeast powder, microcrystalline cellulose, magnesium stearate and flavoring agent in proportion; S3. The purple Ganoderma lucidum extract and yeast powder were mixed evenly, microcrystalline cellulose was added, and stirred at 40-50 ° C for 30-45 minutes to form a premix; S4. Magnesium stearate and flavoring agents were added to the premix and stirring was continued for 10-15 minutes to obtain a total mixture; S5. The total mixture is compressed into tablets, with a tablet weight of 0.5-1.0 g and a hardness of 5-8 kg / cm 2 ; S6. Coat the tablets with a coating liquid of hydroxypropyl methylcellulose solution, with a coating weight gain of 2%-5%. The finished product is obtained after drying.

[0010] Preferably, the stirring speed in S3 is 20-30 r / min, and the stirring temperature is 45±2°C.

[0011] Preferably, the tablet press in S5 has a pressure of 10-15 kN and a tablet pressing speed of 20-30 tablets / minute.

[0012] Preferably, the concentration of the coating solution in S6 is 5%-8%, and the drying temperature is 40-50°C.

[0013] Preferably, the invention is used in medicines or health foods for treating chronic gastritis, gastric ulcer or reflux esophagitis.

[0014] The present invention provides a probiotic Ganoderma lucidum yeast tablet and a production method thereof, which has the following beneficial effects: 1. The probiotic Ganoderma lucidum yeast tablets of the present invention contain a high content of purple Ganoderma lucidum extract. The purple Ganoderma lucidum polysaccharide has the function of regulating immune function, can enhance the body's resistance, help resist the invasion of pathogens such as Helicobacter pylori on the gastric mucosa, and promote the repair of the gastric mucosa. The triterpenoid compounds have significant anti-inflammatory and antioxidant activities, can effectively reduce gastric inflammatory reactions, and relieve pain, heartburn and other symptoms in patients with chronic gastritis, gastric ulcers and reflux esophagitis. Yeast powder is rich in various vitamins, minerals and digestive enzymes, can promote the digestion and absorption of food, improve gastrointestinal function, and further assist in the recovery of gastric diseases.

[0015] 2. The main ingredients of the probiotic Ganoderma lucidum yeast tablets of the present invention, purple Ganoderma lucidum extract and yeast powder, are both derived from natural raw materials. Purple Ganoderma lucidum, as a traditional Chinese medicinal material, has been proven to be highly safe during long-term use. Yeast powder, as a commonly used raw material for food fermentation, also has good safety. Compared with traditional chemical synthetic drugs, it greatly reduces toxic side effects on the human body. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 Flow chart of the method of the present invention. DETAILED DESCRIPTION

[0017] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention. Example 1

[0018] Please see the attached Figure 1 The embodiment of the present invention provides a probiotic Ganoderma lucidum yeast tablet, including 30g of purple Ganoderma lucidum extract, 25g of yeast powder, 20g of microcrystalline cellulose, 2g of magnesium stearate, and 1g of steviol glycoside.

[0019] Magnesium stearate is a commonly used pharmaceutical excipient with high safety at the prescribed dosage. It is only used to improve the molding and lubrication properties of tablets. Microcrystalline cellulose plays a filling role, facilitating the preparation of tablets and has no adverse effects on the human body. Flavoring agents are selected from one or more combinations of menthol, steviol glycosides or citric acid. These flavoring agents are all food-grade additives, safe and reliable, and will not produce additional side effects while improving the taste of the product.

[0020] Preparation of probiotic Ganoderma lucidum yeast tablets: S1. Weigh dry Ganoderma lucidum and crush it to 80 mesh. Add 70% ethanol at a solid-liquid ratio of 1:10 and extract under reflux at 60 ° C twice for 1 hour each time. After the combined extracts are concentrated under reduced pressure to a relative density of 1.2, the extract is dried to obtain a Ganoderma lucidum extract. S2. Weigh 30g of purple Ganoderma lucidum extract, 25g of yeast powder, 20g of microcrystalline cellulose, 2g of magnesium stearate, and 1g of steviol glycosides; S3. The purple Ganoderma lucidum extract and yeast powder were mixed evenly, microcrystalline cellulose was added, and stirred at 40 ° C at a stirring speed of 20r / min for 30 minutes to form a premix; S4. Magnesium stearate and steviol glycosides were added to the premix and stirring was continued for 10 minutes to obtain a total mixture; S5. Using a tablet press, the total blend was compressed into tablets having a weight of 0.5 g and a hardness of 5 kg / cm² at a pressure of 10 kN and a tableting speed of 20 tablets / min; S6. Coat with a 5% concentration of hydroxypropyl methylcellulose solution, and the coating weight gain is 2%. After drying at 40°C, the finished product is obtained.

[0021] Patient performance: Mr. Chen, a 48-year-old patient, suffered from chronic gastritis for 3 years and often experienced symptoms such as stomach pain, bloating, and indigestion. After taking the probiotic Ganoderma lucidum yeast tablets prepared in this example for 3 days, the frequency of stomach pain was significantly reduced, the bloating was alleviated, the appetite increased, and the digestion condition improved. After taking it for 1 month, the symptoms of stomach pain and bloating basically disappeared, and the digestive function returned to normal. Example 2

[0022] The embodiment of the present invention provides a probiotic Ganoderma lucidum yeast tablet, comprising 40g of purple Ganoderma lucidum extract, 30g of yeast powder, 15g of microcrystalline cellulose, 2.5g of magnesium stearate, and 1.5g of menthol.

[0023] Preparation of probiotic Ganoderma lucidum yeast tablets: S1. The dried purple Ganoderma lucidum was crushed to 90 mesh, 80% ethanol was added at a solid-liquid ratio of 1:12, and refluxed at 70 ° C for 2 times, each for 1.5 hours. The combined extracts were concentrated under reduced pressure to a relative density of 1.25 and dried to obtain a purple Ganoderma lucidum extract; S2. Weigh 40g of purple Ganoderma lucidum extract, 30g of yeast powder, 15g of microcrystalline cellulose, 2.5g of magnesium stearate, and 1.5g of menthol; S3. Mix the purple Ganoderma lucidum extract and yeast powder, add microcrystalline cellulose, and stir at 45 ° C and a stirring speed of 25r / min for 40 minutes to form a premix; S4. Magnesium stearate and menthol were added to the premix and stirring was continued for 12 minutes to obtain a total mixture; S5. Under a pressure of 12kN and a tableting speed of 25 tablets / min, the total mixture was compressed into tablets having a weight of 0.7g and a hardness of 6kg / cm²; S6. Coat with 6% hydroxypropyl methylcellulose solution, increase the coating weight by 3%, and dry at 45℃ to make the finished product.

[0024] Patient performance: Ms. Li, 52 years old, suffered from gastric ulcer for 2 years and often experienced abdominal pain and acid reflux after meals. After taking the probiotic Ganoderma lucidum yeast tablets prepared in this example for 3 days, the abdominal pain was alleviated and the number of acid reflux episodes decreased. After taking it for 2 consecutive months, the abdominal pain and acid reflux symptoms after meals almost disappeared, the stomach discomfort was significantly relieved, and the physical condition improved. Example 3

[0025] The embodiment of the present invention provides a probiotic Ganoderma lucidum yeast tablet, which includes 50g of purple Ganoderma lucidum extract, 20g of yeast powder, 10g of microcrystalline cellulose, 3g of magnesium stearate, and 1g of citric acid.

[0026] Preparation of probiotic Ganoderma lucidum yeast tablets: S1. The dried purple Ganoderma lucidum was crushed to 100 mesh, 90% ethanol was added at a solid-liquid ratio of 1:15, and refluxed at 80 ° C for 3 times, each for 2 hours. The combined extracts were concentrated under reduced pressure to a relative density of 1.3 and dried to obtain a purple Ganoderma lucidum extract; S2. Weigh 50g of purple Ganoderma lucidum extract, 20g of yeast powder, 10g of microcrystalline cellulose, 3g of magnesium stearate, and 1g of citric acid; S3. The purple Ganoderma lucidum extract and yeast powder were mixed evenly, microcrystalline cellulose was added, and stirred at 50 ° C and a stirring speed of 30r / min for 45 minutes to form a premix; S4. Magnesium stearate and citric acid were added to the premix and stirring was continued for 15 minutes to obtain a total mixture; S5. The total blend was compressed into tablets having a weight of 1.0 g and a hardness of 8 kg / cm² at a pressure of 15 kN and a rate of 30 tablets / min; S6. Coat with 8% hydroxypropyl methylcellulose solution, with a coating weight gain of 5%, and dry at 50°C to obtain the finished product.

[0027] Patient performance: Mr. Wang, 60 years old, was diagnosed with reflux esophagitis for 4 years and often suffered from symptoms such as heartburn and dysphagia. After taking the probiotic Ganoderma lucidum yeast tablets prepared in this example for 3 days, the heartburn was alleviated and the discomfort when swallowing was relieved. After taking it continuously for 3 months, the heartburn symptoms basically disappeared, the dysphagia was significantly improved, and the quality of life was improved. Example 4

[0028] The embodiment of the present invention provides a probiotic Ganoderma lucidum yeast tablet, comprising 35g, 28g yeast powder, 18g microcrystalline cellulose, 2.2g magnesium stearate, and a mixture of menthol and steviol glycoside, wherein the menthol is 0.8g and the steviol glycoside is 0.5g.

[0029] Preparation of probiotic Ganoderma lucidum yeast tablets: S1. The dried purple Ganoderma lucidum was crushed to 90 mesh, 85% ethanol was added at a solid-liquid ratio of 1:13, and refluxed at 75 ° C for 3 times, each time for 1.5 hours. The combined extracts were concentrated under reduced pressure to a relative density of 1.28 and dried to obtain a purple Ganoderma lucidum extract; S2 weighed purple Ganoderma lucidum extract 35g, yeast powder 28g, microcrystalline cellulose 18g, magnesium stearate 2.2g, menthol and steviol glycoside mixture, menthol 0.8g, steviol glycoside 0.5g; S3. The purple Ganoderma lucidum extract and yeast powder were mixed evenly, microcrystalline cellulose was added, and stirred at 45 ° C and a stirring speed of 23r / min for 35 minutes to form a premix; S4 was added to the premix magnesium stearate and mixed flavoring agents, stirring was continued for 13 minutes to obtain a total mixture; S5. Under a pressure of 13kN and a tableting speed of 22 tablets / min, the total mixture was compressed into tablets having a tablet weight of 0.8g and a hardness of 7kg / cm²; S6. Coat with 7% hydroxypropyl methylcellulose solution, with a coating weight gain of 4%, and dry at 47°C to produce the finished product.

[0030] Patient Performance: Ms. Zhao, 45, suffered from chronic gastritis and indigestion. After taking the probiotic Ganoderma lucidum yeast tablets prepared in this example for three days, her bloating and indigestion symptoms were alleviated, and her appetite improved. After taking it for 1.5 months, her stomach discomfort was significantly relieved, her digestive function was basically back to normal, and she felt more energetic. Example 5

[0031] The embodiment of the present invention provides a probiotic Ganoderma lucidum yeast tablet, comprising 45g of purple Ganoderma lucidum extract, 22g of yeast powder, 12g of microcrystalline cellulose, 1.5g of magnesium stearate, and a mixture of citric acid and menthol, wherein the citric acid is 0.8g and the menthol is 0.7g.

[0032] Preparation of probiotic Ganoderma lucidum yeast tablets: S1. Ganoderma lucidum was dried and crushed to 85 mesh. 75% ethanol was added at a solid-liquid ratio of 1:11 and extracted twice at 65°C under reflux for 1.2 hours each time. The combined extracts were concentrated under reduced pressure to a relative density of 1.22 and dried to obtain a Ganoderma lucidum extract. S2 weighed purple Ganoderma lucidum extract 45g, yeast powder 22g, microcrystalline cellulose 12g, magnesium stearate 1.5g, citric acid and menthol mixture, citric acid 0.8g; menthol 0.7g; S3. The purple Ganoderma lucidum extract and yeast powder were mixed evenly, microcrystalline cellulose was added, and stirred at 43 ° C and a stirring speed of 27r / min for 42 minutes to form a premix; S4 was added to the premix magnesium stearate and mixed flavoring agents, stirring was continued for 14 minutes to obtain a total mixture; S5. The total blend was compressed into tablets having a tablet weight of 0.6 g and a hardness of 6.5 kg / cm² at a pressure of 11 kN and a rate of 28 tablets / min; S6. Coat with a 5.5% concentration of hydroxypropyl methylcellulose solution, with a coating weight gain of 3.5%, and dry at 42°C to obtain the finished product.

[0033] Patient performance: Mr. Sun, 50 years old, had a history of gastric ulcer for one year. After taking the probiotic Ganoderma lucidum yeast tablets prepared in this example for three days, his abdominal pain symptoms were alleviated and his sleep quality improved. After taking it for 2.5 months, the gastric ulcer-related symptoms basically disappeared, his physical condition was good, and his mental state also improved.

[0034] In summary, the present invention prepares various probiotic Ganoderma lucidum yeast tablet embodiments through different raw material ratios and production process parameters. In terms of raw material selection, purple Ganoderma lucidum extract, yeast powder, microcrystalline cellulose, magnesium stearate and different flavoring agents are combined in different proportions. In terms of production process, parameters such as the crushing size of purple Ganoderma lucidum, the material-liquid ratio during extraction, ethanol concentration, extraction temperature and time, the temperature, stirring speed and time when the various ingredients are mixed, and the pressure, speed, tablet weight, hardness, coating solution concentration, coating weight gain and drying temperature of the tableting are all different.

[0035] From the patient experience, for patients with different chronic gastrointestinal diseases such as chronic gastritis, gastric ulcer, reflux esophagitis, etc., after taking the probiotic Ganoderma lucidum yeast tablets prepared in these examples, symptoms were alleviated in the short term, such as reduced stomach pain frequency, reduced abdominal pain, relieved bloating, reduced heartburn, and improved indigestion symptoms. As the duration of use prolonged, the related symptoms of various diseases basically disappeared, digestive function returned to normal, and physical condition and quality of life were significantly improved. This fully demonstrates that the probiotic Ganoderma lucidum yeast tablets of the present invention have a significant effect in treating chronic gastrointestinal diseases.

[0036] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. Probiotic Ganoderma lucidum yeast tablets, characterized in that: The composition includes the following components in weight percentage: Purple Ganoderma Lucidum Extract: 30%-50%; Yeast powder: 20%-35%; Microcrystalline cellulose: 10%-25%; Magnesium stearate: 1%-3%; Flavoring agent: 0.5%-2%.

2. The probiotic Ganoderma lucidum yeast tablet according to claim 1, characterized in that: The polysaccharide content in the purple ganoderma lucidum extract is ≥15%, and the triterpenoid compound content is ≥8%.

3. The probiotic Ganoderma lucidum yeast tablet according to claim 1, characterized in that: The flavoring agent is selected from one or more combinations of menthol, steviol glycoside or citric acid.

4. A method for producing a probiotic Ganoderma lucidum yeast tablet, using the probiotic Ganoderma lucidum yeast tablet according to any one of claims 1 to 3, characterized in that: The following steps are involved: S1. The dried purple Ganoderma lucidum was crushed to 80-100 mesh, 70%-90% ethanol was added at a material-liquid ratio of 1:10-1:15, and refluxed at 60-80 ° C for 2-3 times, each for 1-2 hours. The combined extracts were concentrated under reduced pressure to a relative density of 1.2-1.3 and dried to obtain a purple Ganoderma lucidum extract; S2. Weigh the purple Ganoderma lucidum extract, yeast powder, microcrystalline cellulose, magnesium stearate and flavoring agent in proportion; S3. The purple Ganoderma lucidum extract and yeast powder were mixed evenly, microcrystalline cellulose was added, and stirred at 40-50 ° C for 30-45 minutes to form a premix; S4. Magnesium stearate and flavoring agents were added to the premix and stirring was continued for 10-15 minutes to obtain a total mixture; S5. The total mixture is compressed into tablets, with a tablet weight of 0.5-1.0 g and a hardness of 5-8 kg / cm 2 ; S6. Coat the tablets with a coating liquid of hydroxypropyl methylcellulose solution, with a coating weight gain of 2%-5%. The finished product is obtained after drying.

5. The method for producing the probiotic Ganoderma lucidum yeast tablet according to claim 4, characterized in that: In S3, the stirring speed is 20-30 r / min and the stirring temperature is 45±2°C.

6. The method for producing the probiotic Ganoderma lucidum yeast tablets according to claim 4, characterized in that: The compression force of the S5 tablet press is 10-15 kN and the tableting speed is 20-30 tablets / minute.

7. The method for producing the probiotic Ganoderma lucidum yeast tablets according to claim 4, characterized in that: The concentration of the coating solution in S6 is 5%-8%, and the drying temperature is 40-50°C.

8. The probiotic Ganoderma lucidum yeast tablet according to claim 1, characterized in that Application in medicines or health foods for treating chronic gastritis, gastric ulcer or reflux esophagitis.

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