Traditional Chinese medicine composition for treating rhinitis, nasosinusitis and adenoid hypertrophy and application thereof

Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating rhinitis, nasosinusitis and adenoid hypertrophy and application thereof. The traditional Chinese medicine composition for treating rhinitis and nasosinusitis comprises a goldthread root aqueous solution, a rhizoma acori graminei aqueous solution and fructus cnidii powder, wherein the goldthread root aqueous solution is prepared from goldthread roots, flos magnoliae and fructus perillae; the rhizoma acori graminei water aqua is prepared from flos magnoliae, rhizoma The fructus cnidii powder comprises the following components: cnidium monnieri, radix peucedani, radix angelicae and After patients suffering from rhinitis and nasosinusitis use the traditional Chinese medicine composition, the cure rate is 94% or above, the obvious effective rate of patients suffering from adenoid hypertrophy is 92% or above, and relapse is not prone to occurring.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine combination for treating rhinitis, sinusitis and adenoids hypertrophy and application thereof. Background Art

[0002] Rhinitis is an inflammatory disease of the nasal cavity, with symptoms including nasal congestion, excessive mucus, decreased sense of smell, headache, dizziness, loss of appetite, and memory loss. Rhinitis is further divided into acute and chronic rhinitis. Acute rhinitis is characterized by nasal congestion, sneezing, and clear or mucous nasal discharge. Nasal examination reveals congestion of the nasal mucosa and increased endocrine secretions. The symptoms are more acute and the course of the disease is shorter. Chronic rhinitis is characterized by long-term, intermittent or alternating nasal congestion, and a large amount of nasal discharge. It is also accompanied by symptoms such as dizziness, memory loss, insomnia, and tinnitus. The course of the disease is longer. Nasal examination reveals congestion of the mucosa, which is red or dark red, and swelling of the nasal mucosa, mainly below the inferior turbinate.

[0003] Sinusitis is a nonspecific inflammation of the sinus mucosa and is categorized as acute or chronic. Acute sinusitis is often caused by an upper respiratory tract infection, which can be complicated by both bacterial and viral infections. Chronic sinusitis is more common than acute sinusitis. Multiple sinuses are often affected simultaneously. Sinusitis can lead to decreased sleep quality at night and daytime lethargy. It can also spread to the orbits, causing orbital inflammatory edema, eyelid edema, congestion, swelling, and tenderness.

[0004] The adenoids are located at the junction of the roof and posterior walls of the nasopharynx, between the bilateral pharyngeal recesses. Adenoid hypertrophy is a common childhood disease, occurring most frequently in children aged 3-10 years. It is often caused by repeated bacterial or viral infection of the nasopharynx and its adjacent areas, or repeated inflammation and stimulation of the adenoids themselves, leading to pathological proliferation of the adenoids. Clinical manifestations may include high fever, dull pain in the nasopharynx, headache, general malaise, severe nasal congestion, mouth breathing, snoring during sleep, and in severe cases, obstructive sleep apnea-hypopnea syndrome. Clinically, children with adenoid hypertrophy are primarily treated with surgery, which causes pain to the children.

[0005] Currently, there are two types of medications for rhinitis and sinusitis. Topical medications, such as sprays and nasal drops, lack long-term efficacy and are prone to relapse after discontinuation. Oral medications, primarily traditional Chinese medicine, also offer limited efficacy. Therefore, effective, long-term medications are needed to treat rhinitis, sinusitis, and adenoids. Summary of the Invention

[0006] In order to solve the above problems, the present invention provides a Chinese medicine combination for treating rhinitis, sinusitis and adenoids hypertrophy and its application. The Chinese medicine combination provided by the present invention can effectively treat rhinitis, sinusitis and adenoids hypertrophy and is not prone to recurrence.

[0007] In order to achieve the above object, the present invention provides the following technical solutions:

[0008] The present invention provides a Chinese medicine combination for treating rhinitis, sinusitis and adenoids hypertrophy, comprising a coptis chinensis aqueous solution, acorus tatarinowii aqueous solution and cnidium monnieri powder; the coptis chinensis aqueous solution, acorus tatarinowii aqueous solution and cnidium monnieri powder are packaged separately;

[0009] The coptis chinensis aqueous solution is prepared from the following components in parts by weight: 25-35 parts of coptis chinensis, 25-35 parts of magnolia flower and 15-25 parts of perilla seed;

[0010] The Acorus calamus water preparation is prepared from the following components in parts by weight: 25-35 parts of magnolia flower, 25-35 parts of Acorus calamus and 25-35 parts of asarum;

[0011] The cnidium monnieri powder comprises the following components in parts by weight: 15-25 parts of cnidium monnieri, 10-20 parts of peucedanum chinense, 5-15 parts of angelica dahurica, 1-5 parts of artemisia annua, 1-5 parts of mulberry leaves, 3-8 parts of ligusticum chuanxiong, 1-5 parts of wolfberry fruits, 1-5 parts of oriental rhizome, 1-8 parts of inula flower, 1-5 parts of lotus root, 1-5 parts of linseed, 1-5 parts of bupleurum root, 3-8 parts of sea buckthorn and 8-15 parts of borneol.

[0012] Preferably, the Coptidis lotus water solution is prepared from the following components in parts by weight: 30 parts of Coptidis lotus, 30 parts of Magnolia Flos and 20 parts of Perilla Seed.

[0013] Preferably, the Acorus calamus aqueous solution is prepared from the following components in parts by weight: 30 parts of magnolia flower, 30 parts of Acorus calamus and 30 parts of asarum.

[0014] Preferably, the Cnidium monnieri powder comprises the following components in parts by weight: 20 parts of Cnidium monnieri, 15 parts of Peucedanum chinense, 9 parts of Angelica dahurica, 3 parts of Artemisia annua, 3 parts of Morus alba, 5 parts of Ligusticum chuanxiong, 3 parts of Lycium barbarum, 3 parts of Alisma orientale, 5 parts of Inula flower, 3 parts of Lotus japonica, 3 parts of Linseed, 3 parts of Bupleurum chinense, 5 parts of Seabuckthorn and 11 parts of Borneol.

[0015] Preferably, the preparation method of the Coptidis Rhizoma aqueous solution comprises the following steps: mixing the Coptidis Rhizoma, Magnoliae Flos, Perilla Fructus and ethanol solution and performing alcohol extraction to obtain an alcohol extract;

[0016] The alcohol extract is filtered to obtain a filtrate which is a Coptis chinensis aqueous solution.

[0017] Preferably, the volume ratio of the total mass of the Coptidis Rhizoma, Magnoliae Flos and Perilla Fructus to the ethanol solution is 1 g:1.5 mL; and the volume percentage of the ethanol solution is 80%.

[0018] Preferably, the preparation method of the Acorus calamus aqueous solution comprises the following steps: mixing the Acorus calamus, Magnolia Flos, Asarum and an ethanol solution and performing alcohol extraction to obtain an alcohol extract;

[0019] The alcohol extract is filtered to obtain a filtrate which is an Acorus calamus aqueous solution.

[0020] Preferably, the volume ratio of the total mass of the Acorus calamus, Magnolia Flos and Asarum to the ethanol solution is 1 g:1.5 mL; and the volume percentage of the ethanol solution is 80%.

[0021] Preferably, the preparation method of the Cnidium monnieri powder comprises the following steps: mixing the Cnidium monnieri, Peucedanum chinense, Angelica dahurica, Artemisia selengensis, mulberry leaves, Ligusticum chuanxiong, Lycium barbarum fruit, Alisma orientale, Inula japonica, Lotus japonica, linseed, Bupleurum chinense, Hippophae rhamnoides and borneol, then grinding the mixture, passing through a 200-mesh sieve, and the sieved material is the Cnidium monnieri powder.

[0022] The present invention also provides the use of the Chinese medicine combination described in the above technical solution in preparing medicines for treating rhinitis, sinusitis and adenoids hypertrophy.

[0023] The Chinese medicine combination provided by the present invention comprises a coptis chinensis aqueous solution with antibacterial and anti-inflammatory effects, a calamus tatarinowii aqueous solution with orifice-opening and brain-awakening effects, and a cnidium monnieri powder with the effects of dispelling cold, dissipating heat, strengthening the spleen, and stimulating appetite and nourishing the lungs. The combination of the three can effectively treat rhinitis, sinusitis, and adenoids hypertrophy, and is less likely to relapse.

[0024] Beneficial effects of the present invention:

[0025] After the patients with rhinitis and sinusitis use the Chinese medicine combination of the present invention, the cure rate is above 94%, the markedly effective rate of the patients with adenoid hypertrophy is above 92%, and the disease is not prone to relapse. DETAILED DESCRIPTION

[0026] The present invention provides a traditional Chinese medicine combination for treating rhinitis, sinusitis and adenoid hypertrophy, comprising a coptis chinensis aqueous solution, acorus calamus aqueous solution and cnidium monnieri powder; the coptis chinensis aqueous solution, acorus calamus aqueous solution and cnidium monnieri powder are packaged separately; the coptis chinensis aqueous solution is prepared from the following components in parts by weight: 25-35 parts of coptis chinensis, 25-35 parts of magnolia buds and 15-25 parts of perilla seeds; the acorus calamus aqueous solution is prepared from the following components in parts by weight: 25-35 parts of magnolia buds The cnidium monnieri powder comprises the following components in parts by weight: 15-25 parts of cnidium monnieri, 10-20 parts of peucedanum, 5-15 parts of angelica dahurica, 1-5 parts of artemisia, 1-5 parts of mulberry leaves, 3-8 parts of chuanxiong, 1-5 parts of wolfberry fruits, 1-5 parts of oriental rhizome, 1-8 parts of inula flower, 1-5 parts of lotus root, 1-5 parts of linseed, 1-5 parts of bupleurum root, 3-8 parts of sea buckthorn and 8-15 parts of borneol. The present invention does not specifically limit the sources of the above-mentioned traditional Chinese medicines, and those skilled in the art can use conventional commercially available ones.

[0027] In the present invention, the Coptidis lotus root aqueous solution is preferably prepared from the following components in parts by weight: 30 parts Coptidis lotus root, 30 parts magnolia flower, and 20 parts perilla seed. In the present invention, the method for preparing the Coptidis lotus root aqueous solution preferably comprises the following steps: mixing the Coptidis lotus root, magnolia flower, and perilla seed with an ethanol solution and performing alcohol extraction to obtain an alcohol extract; and filtering the alcohol extract to obtain a filtrate as the Coptidis lotus root aqueous solution. In the present invention, the volume ratio of the total mass of the Coptidis lotus root, magnolia flower, and perilla seed to the ethanol solution is preferably 1g:1.5mL. In the present invention, the volume percentage of the ethanol solution is preferably 80%.

[0028] In the present invention, the Acorus calamus aqueous solution is preferably prepared from the following components in parts by weight: 30 parts of Magnolia Flos, 30 parts of Acorus calamus, and 30 parts of Asarum. In the present invention, the preparation method of the Acorus calamus aqueous solution preferably includes the following steps: mixing the Acorus calamus, Magnolia Flos, and Asarum with an ethanol solution and performing alcohol extraction to obtain an ethanol extract; filtering the ethanol extract to obtain a filtrate as the Acorus calamus aqueous solution. In the present invention, the volume ratio of the total mass of the Acorus calamus, Magnolia Flos, and Asarum to the ethanol solution is preferably 1g:1.5mL. In the present invention, the volume percentage of the ethanol solution is preferably 80%.

[0029] In the present invention, the Cnidium monnieri powder preferably comprises the following components in parts by weight: 20 parts of Cnidium monnieri, 15 parts of Peucedanum chinense, 9 parts of Angelica dahurica, 3 parts of Artemisia herba, 3 parts of Morus alba, 5 parts of Ligusticum chuanxiong, 3 parts of Lycium barbarum, 3 parts of Rhizoma Alismatis, 5 parts of Inula flower, 3 parts of Lotus japonicus, 3 parts of Linseed, 3 parts of Bupleurum chinense, 5 parts of Hippophae rhamnoides, and 11 parts of Borneol. In the present invention, the preparation method of the Cnidium monnieri powder preferably comprises the following steps: mixing the Cnidium monnieri, Peucedanum chinense, Angelica dahurica, Artemisia herba, mulberry leaf, Ligusticum chuanxiong, Lycium barbarum, Rhizoma Alismatis, Inula flower, Lotus japonicus, linseed, Bupleurum chinense, Hippophae rhamnoides, and Borneol, then grinding the mixture, passing through a 200-mesh sieve, and the sieved material is the Cnidium monnieri powder.

[0030] In the present invention, the method of using the Chinese medicine combination for treating rhinitis, sinusitis and adenoids hypertrophy is preferably as follows: spray the Coptis chinensis aqueous solution twice in each nostril, after a 1-minute interval, spray the Acorus calamus aqueous solution twice in each nostril, after a 1-minute interval, spray the Cnidium monnieri powder six times in each nostril, and the patient should do this once in the morning and evening every day.

[0031] The present invention also provides the use of the Chinese medicine combination described in the above technical solution in preparing medicines for treating rhinitis and sinusitis.

[0032] In order to further illustrate the present invention, the present invention is described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention.

[0033] Example 1

[0034] A traditional Chinese medicine combination for treating rhinitis, sinusitis and adenoids hypertrophy comprises coptis chinensis water, calamus tatarinowii water and cnidium monnieri powder; the coptis chinensis water, calamus tatarinowii water and cnidium monnieri powder are packaged separately.

[0035] The coptis chinensis aqueous solution is prepared from the following components in parts by weight: 30 parts of coptis chinensis, 30 parts of magnolia buds, and 20 parts of perilla seeds. The preparation method of the coptis chinensis aqueous solution comprises: mixing the coptis chinensis, magnolia buds, perilla seeds, and an ethanol solution, performing alcohol extraction to obtain an alcohol extract; filtering the alcohol extract to obtain a filtrate as the coptis chinensis aqueous solution; wherein the volume ratio of the total mass of the coptis chinensis, magnolia buds, and perilla seeds to the ethanol solution is 1 g:1.5 mL, and the volume percentage of the ethanol solution is 80%.

[0036] The Acorus calamus aqueous solution is prepared from the following components in parts by weight: 30 parts of magnolia flower, 30 parts of Acorus calamus, and 30 parts of asarum. The preparation method of the Acorus calamus aqueous solution comprises: mixing the Acorus calamus, magnolia flower, asarum, and an ethanol solution, performing alcohol extraction to obtain an ethanol extract; filtering the ethanol extract to obtain a filtrate as the Acorus calamus aqueous solution, wherein the volume ratio of the total mass of the Acorus calamus, magnolia flower, and asarum to the ethanol solution is 1 g:1.5 mL, and the volume percentage of the ethanol solution is 80%.

[0037] The cnidium monnieri powder comprises the following components in parts by weight: 20 parts of cnidium monnieri, 15 parts of peucedanum chinense, 9 parts of angelica dahurica, 3 parts of artemisia herba, 3 parts of mulberry leaves, 5 parts of ligusticum chuanxiong, 3 parts of wolfberry fruits, 3 parts of oriental rhizome, 5 parts of inula flower, 3 parts of lotus root, 3 parts of linseed, 3 parts of bupleurum, 5 parts of sea buckthorn and 11 parts of borneol. The preparation method of the cnidium monnieri powder comprises the following steps: mixing cnidium monnieri, peucedanum chinense, angelica dahurica, artemisia herba, mulberry leaves, ligusticum chuanxiong, wolfberry fruits, oriental rhizome, inula flower, lotus root, linseed, bupleurum, sea buckthorn and borneol, then grinding the mixture and passing the mixture through a 200-mesh sieve. The sieved material is the cnidium monnieri powder.

[0038] Example 2

[0039] A traditional Chinese medicine combination for treating rhinitis, sinusitis and adenoids hypertrophy comprises coptis chinensis water, calamus tatarinowii water and cnidium monnieri powder; the coptis chinensis water, calamus tatarinowii water and cnidium monnieri powder are packaged separately.

[0040] The coptis chinensis aqueous solution is prepared from the following components in parts by weight: 25 parts of coptis chinensis, 35 parts of magnolia flower and 18 parts of perilla seed; the preparation method of the coptis chinensis aqueous solution comprises: mixing coptis chinensis, magnolia flower, perilla seed and an ethanol solution, performing alcohol extraction to obtain an alcohol extract; filtering the alcohol extract to obtain a filtrate as the coptis chinensis aqueous solution; wherein the volume ratio of the total mass of coptis chinensis, magnolia flower and perilla seed to the ethanol solution is 1 g:1.5 mL, and the volume percentage of the ethanol solution is 80%.

[0041] The Acorus calamus aqueous solution is prepared from the following components in parts by weight: 35 parts of magnolia flower, 28 parts of Acorus calamus and 32 parts of asarum. The preparation method of the Acorus calamus aqueous solution comprises: mixing the Acorus calamus, magnolia flower, asarum and an ethanol solution, performing alcohol extraction to obtain an ethanol extract; filtering the ethanol extract to obtain a filtrate as the Acorus calamus aqueous solution, wherein the volume ratio of the total mass of the Acorus calamus, magnolia flower and asarum to the ethanol solution is 1 g:1.5 mL, and the volume percentage of the ethanol solution is 80%.

[0042] The cnidium monnieri powder comprises the following components in parts by weight: 25 parts of cnidium monnieri, 10 parts of peucedanum chinense, 8 parts of angelica dahurica, 4 parts of artemisia herba, 5 parts of mulberry leaves, 6 parts of ligusticum chuanxiong, 2 parts of wolfberry fruits, 5 parts of oriental rhizome, 6 parts of inula flower, 1 part of lotus root, 5 parts of linseed, 3 parts of bupleurum, 5 parts of sea buckthorn and 10 parts of borneol. The preparation method of the cnidium monnieri powder comprises the following steps: mixing cnidium monnieri, peucedanum chinense, angelica dahurica, artemisia herba, mulberry leaves, ligusticum chuanxiong, wolfberry fruits, oriental rhizome, inula flower, lotus root, linseed, bupleurum, sea buckthorn and borneol, then grinding the mixture and passing the mixture through a 200-mesh sieve. The sieved material is the cnidium monnieri powder.

[0043] Example 3

[0044] A traditional Chinese medicine combination for treating rhinitis, sinusitis and adenoids hypertrophy comprises coptis chinensis water, calamus tatarinowii water and cnidium monnieri powder; the coptis chinensis water, calamus tatarinowii water and cnidium monnieri powder are packaged separately.

[0045] The coptis chinensis aqueous solution is prepared from the following components in parts by weight: 32 parts of coptis chinensis, 25 parts of magnolia flower and 25 parts of perilla seed; the preparation method of the coptis chinensis aqueous solution comprises: mixing coptis chinensis, magnolia flower, perilla seed and an ethanol solution and performing alcohol extraction to obtain an alcohol extract; filtering the alcohol extract to obtain a filtrate as the coptis chinensis aqueous solution; wherein the volume ratio of the total mass of coptis chinensis, magnolia flower and perilla seed to the ethanol solution is 1 g:1.5 mL, and the volume percentage of the ethanol solution is 80%.

[0046] The Acorus calamus aqueous solution is prepared from the following components in parts by weight: 25 parts of magnolia flower, 35 parts of Acorus calamus, and 25 parts of asarum. The preparation method of the Acorus calamus aqueous solution comprises: mixing the Acorus calamus, magnolia flower, asarum, and an ethanol solution, performing alcohol extraction to obtain an ethanol extract; filtering the ethanol extract to obtain a filtrate as the Acorus calamus aqueous solution, wherein the volume ratio of the total mass of the Acorus calamus, magnolia flower, and asarum to the ethanol solution is 1 g:1.5 mL, and the volume percentage of the ethanol solution is 80%.

[0047] The cnidium monnieri powder comprises the following components in parts by weight: 22 parts of cnidium monnieri, 25 parts of peucedanum chinense, 9 parts of angelica dahurica, 4 parts of artemisia herba, 1 part of mulberry leaf, 6 parts of ligusticum chuanxiong, 5 parts of wolfberry fruit, 1 part of oriental rhizome, 3 parts of inula flower, 2 parts of lotus root, 4 parts of linseed, 2 parts of bupleurum root, 4 parts of sea buckthorn and 9 parts of borneol. The preparation method of the cnidium monnieri powder comprises the following steps: mixing cnidium monnieri, peucedanum chinense, angelica dahurica, artemisia herba, mulberry leaf, ligusticum chuanxiong, wolfberry fruit, oriental rhizome, inula flower, lotus root, linseed, bupleurum root, sea buckthorn and borneol, then grinding the mixture and passing the mixture through a 200-mesh sieve. The sieved material is the cnidium monnieri powder.

[0048] Application Example 1

[0049] 1. In 2024, 300 patients with sinusitis, aged 6-70 years, with a disease course of 1 month to 8 years, were recruited and randomly divided into 3 groups, with 100 patients in each group.

[0050] 2. Patient selection criteria:

[0051] Headache: manifested as dull pain, bloating, etc., which is worse during the day and lighter at night;

[0052] Runny nose: The nasal discharge is purulent or mucopurulent, yellow or yellow-green in color, and the amount of nasal discharge is variable;

[0053] Nasal congestion: accompanied by temporary olfactory impairment or complete obstruction of the nasal cavity.

[0054] 3. Treatment methods:

[0055] Using the Chinese herbal combination prepared in Examples 1 to 3, the patient sprayed the Rhizoma Coptidis aqueous solution twice in each nostril, after a 1-minute interval, then sprayed the Rhizoma Acorus Tatarinowii aqueous solution twice in each nostril, after a 1-minute interval, and then sprayed the Fructus Cnidium monnieri powder six times in each nostril, once daily, morning and evening. The treatment results were recorded for 15 days, and recurrence was recorded after 6 months.

[0056] 4. Treatment standards:

[0057] Cured: Symptoms such as nasal congestion, runny nose, and headache disappear, sense of smell is restored, and breathing becomes smooth;

[0058] Markedly effective: Headache and nasal congestion basically disappeared, nasal discharge was significantly reduced, breathing became smoother, and sense of smell was significantly improved;

[0059] Effective: Headache and nasal congestion are relieved, purulent nasal discharge is reduced, and improvement in sense of smell is not obvious;

[0060] Ineffective: No significant improvement in headache, runny nose, and nasal congestion.

[0061] The statistical results are shown in Table 1.

[0062] Table 1 Results of treating sinusitis with the combination of Chinese medicines in Examples 1 to 3

[0063] Number of patients cure Significant effect efficient invalid Relapse Example 1 100 98 1 1 0 no Example 2 100 95 3 2 0 no Example 3 100 96 2 2 0 no

[0064] It can be seen from Table 1 that after the sinusitis patients used the Chinese medicine combination of the present invention, the cure rate was above 95% and the disease was not prone to relapse.

[0065] Application Example 2

[0066] 1. In 2024, 300 patients with rhinitis were collected, aged 10-65 years, with a disease course of 1-6 years; they were randomly divided into 3 groups, with 100 people in each group.

[0067] 2. Patient selection criteria:

[0068] Runny nose: clear or mucous, variable amount of nasal discharge;

[0069] Nasal congestion: continuous, intermittent or alternating.

[0070] 3. Treatment methods:

[0071] Using the Chinese herbal combination prepared in Examples 1 to 3, the patient sprayed the Rhizoma Coptidis aqueous solution twice in each nostril, after a 1-minute interval, then sprayed the Rhizoma Acorus Tatarinowii aqueous solution twice in each nostril, after a 1-minute interval, and then sprayed the Fructus Cnidium monnieri powder six times in each nostril, once daily, morning and evening. The treatment results were recorded for 15 days, and recurrence was recorded after 6 months.

[0072] 4. Treatment standards:

[0073] Cured: All symptoms of nasal congestion and runny nose disappeared;

[0074] Significantly effective: Symptoms of nasal congestion and runny nose were significantly improved;

[0075] Effective: relieved nasal congestion and runny nose symptoms;

[0076] Ineffective: There was no significant improvement in nasal congestion and runny nose symptoms.

[0077] The statistical results are shown in Table 2.

[0078] Table 2 Results of rhinitis treated with the Chinese medicine combination of Examples 1 to 3

[0079] Number of patients cure Significant effect efficient invalid Relapse Example 1 100 97 3 0 0 no Example 2 100 96 2 2 0 no Example 3 100 94 4 2 0 no

[0080] It can be seen from Table 2 that after rhinitis patients use the Chinese medicine combination of the present invention, the cure rate is above 94% and the disease is less likely to relapse.

[0081] Application Example 3

[0082] 1. In 2024, 300 patients with adenoid hypertrophy, aged 2-7 years, with a disease course of more than 6 months, were recruited and randomly divided into 3 groups, with 100 patients in each group.

[0083] 2. Patient selection criteria:

[0084] 1) Nasal symptoms: nasal congestion, snoring during sleep, daytime lethargy, poor memory, slurred speech, nasal voice, and increased nasal discharge;

[0085] 2) Ear symptoms: tinnitus, hearing loss, ear discharge, etc.

[0086] 3) Throat and lower respiratory tract symptoms: cough, throat discomfort, often upper respiratory tract infection and concurrent bronchitis;

[0087] 4) Maxillofacial skeletal dysplasia: narrow and enlarged maxilla, narrow and high-arched hard palate, irregular teeth, protruding upper incisors, thick and short upper lip, eversion; lack of expression, and dumb mouth opening;

[0088] 5) X-ray examination can show enlarged adenoids.

[0089] 3. Treatment methods:

[0090] Using the Chinese herbal combination prepared in Examples 1 to 3, the patient sprayed the Rhizoma Coptidis aqueous solution twice in each nostril, after a 1-minute interval, then sprayed the Rhizoma Acorus Tatarinowii aqueous solution twice in each nostril, after a 1-minute interval, and then sprayed the Fructus Cnidium monnieri powder six times in each nostril, once daily, morning and evening. The treatment results were recorded for 15 days, and recurrence was recorded after 6 months.

[0091] 4. Treatment standards:

[0092] Markedly effective: clinical symptoms and signs of adenoid hypertrophy disappear, and adenoid hypertrophy disappears on lateral nasopharyngeal X-ray;

[0093] Effective: clinical symptoms and signs of adenoid hypertrophy are alleviated, and nasopharyngeal X-ray shows adenoid hypertrophy is reduced;

[0094] Ineffective: There was no change in the clinical symptoms and signs of adenoid hypertrophy and in the nasopharyngeal X-ray.

[0095] Table 3 Results of the Chinese medicine combination for treating adenoid hypertrophy in Examples 1 to 3

[0096] Number of patients Significant effect efficient invalid Relapse Example 1 100 96 4 0 no Example 2 100 92 7 1 no Example 3 100 94 6 0 no

[0097] It can be seen from Table 3 that after the patients with adenoid hypertrophy use the Chinese medicine combination of the present invention, the effective rate is above 92% and the disease is not prone to relapse.

[0098] Although the above embodiment provides a detailed description of the present invention, it is only a part of the embodiments of the present invention, not all of the embodiments. People can also obtain other embodiments based on this embodiment without creativity, and these embodiments all fall within the scope of protection of the present invention.

Claims

1. A Chinese medicine combination for treating rhinitis, sinusitis and adenoids hypertrophy, characterized in that: It includes coptis chinensis water, calamus tatarinowii water and cnidium monnieri powder; the coptis chinensis water, calamus tatarinowii water and cnidium monnieri powder are packaged separately; The coptis chinensis aqueous solution is prepared from the following components in parts by weight: 25-35 parts of coptis chinensis, 25-35 parts of magnolia flower and 15-25 parts of perilla seed; The Acorus calamus water preparation is prepared from the following components in parts by weight: 25-35 parts of magnolia flower, 25-35 parts of Acorus calamus and 25-35 parts of asarum; The cnidium monnieri powder comprises the following components in parts by weight: 15-25 parts of cnidium monnieri, 10-20 parts of peucedanum chinense, 5-15 parts of angelica dahurica, 1-5 parts of artemisia annua, 1-5 parts of mulberry leaves, 3-8 parts of ligusticum chuanxiong, 1-5 parts of wolfberry fruits, 1-5 parts of oriental rhizome, 1-8 parts of inula flower, 1-5 parts of lotus root, 1-5 parts of linseed, 1-5 parts of bupleurum root, 3-8 parts of sea buckthorn and 8-15 parts of borneol.

2. The Chinese medicine combination according to claim 1, characterized in that The coptis chinensis aqueous solution is prepared from the following components in parts by weight: 30 parts of coptis chinensis, 30 parts of magnolia flower and 20 parts of perilla seed.

3. The Chinese medicine combination according to claim 1, characterized in that The Acorus calamus water preparation is prepared from the following components in parts by weight: 30 parts of magnolia flower, 30 parts of Acorus calamus and 30 parts of asarum.

4. The Chinese medicine combination according to claim 1, characterized in that The cnidium monnieri powder comprises the following components in parts by weight: 20 parts of cnidium monnieri, 15 parts of peucedanum chinense, 9 parts of angelica dahurica, 3 parts of artemisia, 3 parts of mulberry leaves, 5 parts of ligusticum chuanxiong, 3 parts of wolfberry fruits, 3 parts of oriental water chestnuts, 5 parts of inula flower, 3 parts of lotus root, 3 parts of linseed, 3 parts of bupleurum root, 5 parts of sea buckthorn and 11 parts of borneol.

5. The Chinese medicine combination according to claim 1 or 2, characterized in that: The preparation method of the coptis chinensis aqueous solution comprises the following steps: mixing the coptis chinensis, magnolia flower, perilla seed and ethanol solution and performing alcohol extraction to obtain an alcohol extract; The alcohol extract is filtered to obtain a filtrate which is a Coptis chinensis aqueous solution.

6. The Chinese medicine combination according to claim 5, characterized in that: The volume ratio of the total mass of the coptis chinensis, magnolia flower and perilla seed to the ethanol solution is 1g:1.5mL; and the volume percentage of the ethanol solution is 80%.

7. The Chinese medicine combination according to claim 1 or 3, characterized in that: The preparation method of the Acorus calamus aqueous solution comprises the following steps: mixing the Acorus calamus, Magnolia flos, Asarum sieboldii and ethanol solution and performing alcohol extraction to obtain an alcohol extract; The alcohol extract is filtered to obtain a filtrate which is an Acorus calamus aqueous solution.

8. The Chinese medicine combination according to claim 7, characterized in that: The volume ratio of the total mass of the Acorus calamus, the magnolia flower and the asarum to the ethanol solution is 1 g:1.5 mL; and the volume percentage of the ethanol solution is 80%.

9. The Chinese medicine combination according to claim 1 or 3, characterized in that: The preparation method of the Cnidium monnieri powder comprises the following steps: mixing the Cnidium monnieri, Peucedanum chinense, Angelica dahurica, Artemisia selengensis, mulberry leaves, Chuanxiong rhizome, Lycium barbarum fruit, Rhizoma Alismatis, Inula flower, Lotus japonica root, linseed, Bupleurum chinense, Sea buckthorn and borneol, then grinding the mixture, passing the mixture through a 200-mesh sieve, and the sieved product is the Cnidium monnieri powder.

10. Use of the Chinese medicinal combination according to any one of claims 1 to 9 in the preparation of a medicament for treating rhinitis, sinusitis and adenoids hypertrophy.