Traditional Chinese medicine composition for preventing constipation after stroke, plaster and preparation method thereof

Abstract

The invention relates to a traditional Chinese medicine composition for preventing constipation after stroke, an application and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 12 to 15 parts of fructus aurantii, 9 to 12 parts of radix aucklandiae, 10 to 15 parts of fructus akebiae, 6 to 8 parts of cassia twig, 10 to 12 parts of vinegar rhizoma cyperi, 6 to 8 parts of rhizoma zingiberis, 10 to 15 parts of poria cocos and 3 to 5 parts of rhizoma cimicifugae. The traditional Chinese medicine composition disclosed by the invention is reasonable in compatibility, has the effects of relaxing bowel, warming yang, relaxing bowels, invigorating spleen, replenishing qi, ascending lucidity, descending turbid and the like, promotes the recovery of normal conduction functions of intestinal tracts, and effectively prevents the occurrence of early constipation of apoplexy patients.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine composition for preventing post-stroke constipation, a patch and a preparation method thereof. Background Art

[0002] Stroke is one of the common diseases in middle-aged and elderly people. It has the characteristics of rapid onset, severe condition, high mortality rate and high recurrence rate, which seriously affects human health. Constipation is one of the common complications of cerebral stroke, which is mainly manifested in reduced stool volume, reduced bowel movement frequency, difficulty in defecation, prolonged defecation time, etc. The main causes of constipation are the influence of the disease and the negative emotions such as tension and anxiety caused by the disease, reduced patient activity, changes in defecation posture and habits and environment, gastrointestinal dysfunction, etc. Once constipation occurs, the toxins in the feces accumulated in the body will be absorbed. The longer the time, the greater the harm, and even other complications such as worsening of the cerebral stroke condition may occur. Therefore, it is very important for stroke patients to keep their bowels open, and it is best to avoid the occurrence of constipation in the early stages of stroke. The present invention is based on the guiding principle of "preventive treatment" of traditional Chinese medicine, and prevents its occurrence before constipation occurs in stroke patients, promotes stroke condition recovery and reduces complications. Summary of the Invention

[0003] In order to solve the above technical problems, the present invention provides a traditional Chinese medicine composition, a patch and a preparation method thereof for preventing post-stroke constipation.

[0004] In a first aspect, the present invention provides a traditional Chinese medicine composition for preventing post-stroke constipation, comprising the following raw materials in parts by weight: 12-15 parts of Citrus aurantium, 9-12 parts of costus root, 10-15 parts of cyperus rotundus, 6-8 parts of cinnamon twig, 10-12 parts of vinegar-soaked Cyperus rotundus, 6-8 parts of dried ginger, 10-15 parts of Poria cocos, and 3-5 parts of Cimicifuga heracleifolia.

[0005] In the above further technical solution, the Chinese medicine composition includes the following raw materials in parts by weight: 12 parts of Citrus aurantium, 10 parts of costus root, 10 parts of eucommia bark, 7 parts of cinnamon twig, 10 parts of vinegar-soaked Cyperus rotundus, 6 parts of dried ginger, 15 parts of Poria cocos, and 5 parts of Cimicifuga heracleifolia.

[0006] In the above further technical solution, the Chinese medicine composition includes the following raw materials in parts by weight: 13 parts of Citrus aurantium, 9 parts of costus root, 14 parts of euphorbia pulegosa, 6 parts of cinnamon twig, 11 parts of vinegar-soaked Cyperus rotundus, 8 parts of dried ginger, 13 parts of Poria cocos, and 4 parts of Cimicifuga heracleifolia.

[0007] In the above further technical solution, the Chinese medicine composition includes the following raw materials in parts by weight: 15 parts of Citrus aurantium, 12 parts of costus root, 12 parts of eucommia bark, 8 parts of cinnamon twig, 12 parts of vinegar-soaked Cyperus rotundus, 7 parts of dried ginger, 10 parts of Poria cocos, and 3 parts of Cimicifuga heracleifolia.

[0008] In the above further technical solution, the Citrus aurantium is stir-fried Citrus aurantium.

[0009] In a second aspect, the present invention provides a traditional Chinese medicine patch for preventing post-stroke constipation, comprising the above-mentioned traditional Chinese medicine composition.

[0010] Furthermore, the Chinese medicine patch is applied on the Shenque acupoint.

[0011] In a third aspect, the present invention provides a method for preparing a Chinese medicine patch for preventing post-stroke constipation, comprising the following steps: weighing a certain amount of raw materials, processing them into powder, and passing them through a 50-250 mesh sieve to obtain fine powder; placing them into a container, mixing the fine powder raw materials, adding an application medium and blending them into a paste; taking the paste and spreading it in an application anti-seepage circle to obtain a Chinese medicine patch.

[0012] Furthermore, the application medium is at least one of sesame oil, vinegar, honey, glycerin, and rice wine, and the mass ratio of the fine powder to the application medium is 1:(0.5-3).

[0013] Furthermore, the application medium is sesame oil, and the mass ratio of the fine powder to the application medium is 1:1.

[0014] Furthermore, the paste is placed at 3-4° C. for later use and is returned to temperature before use.

[0015] The efficacy and pharmacological effects of the above-mentioned prescription drugs are analyzed as follows:

[0016] Citrus aurantium [Nature and Flavor and Meridians] Bitter, pungent, sour, slightly cold. Enters the spleen and stomach meridians. [Functions and Indications] Regulates qi and relieves fullness, promotes circulation, and relieves bloating. It can be used to treat chest and flank qi stagnation, distension and pain, indigestion, phlegm and fluid retention, and organ prolapse.

[0017] Costus Root [Nature and Flavor and Meridians] Pungent, bitter, and warm. It enters the spleen, stomach, large intestine, triple burner, and gallbladder meridians. [Functions and Indications] It promotes qi circulation and relieves pain, strengthens the spleen, and aids digestion. It is used for chest, flank, and abdominal distension and pain, heaviness after diarrhea, indigestion, and loss of appetite.

[0018] Yuzhizi [Nature and Flavor and Meridians] Bitter, cold. Enters the Liver, Gallbladder, Stomach, and Bladder meridians. [Functions and Indications] Soothes the Liver and regulates Qi, promotes blood circulation and relieves pain, disperses stagnation, and promotes urination. Used for epigastric and flank pain, dysmenorrhea, amenorrhea, phlegm nodules, and dysuria.

[0019] Cinnamon Twig [Nature and Flavor and Meridians] Pungent, sweet, warm. Entries the Heart, Lung, and Bladder meridians. [Functions and Indications] Induces sweating and relaxes muscles, warms and unclogs the meridians, enhances yang and transforms qi, and balances and descends qi. Used for colds, cold and pain in the abdomen due to wind and cold, amenorrhea due to blood cold, joint pain, phlegm and fluid retention, edema, palpitations, and typhoid fever.

[0020] Vinegar-scented Cyperus rotundus [Nature and Flavor and Meridians] Pungent, slightly bitter, slightly sweet, neutral. Enters the Liver, Spleen, and Triple Burner meridians. [Functions and Indications] Soothes the liver and relieves depression, regulates qi and relieves fullness, regulates menstruation and relieves pain. Used for liver depression and qi stagnation, chest and flank pain, hernia pain, breast pain, spleen and stomach qi stagnation, abdominal distension and pain, menstrual irregularities, amenorrhea, and dysmenorrhea.

[0021] Dried Ginger [Nature and Flavor and Meridians] Pungent, hot. Enters the spleen, stomach, kidney, heart, and lung meridians. [Functions and Indications] Warms the middle and dispels cold, restores yang and unblocks the meridians, warms the lungs and transforms fluid. Used for cold pain in the abdomen, vomiting and diarrhea, cold extremities and weak pulse, and cough and wheezing due to cold fluid.

[0022] Poria [Nature and Flavor and Meridians] Sweet, mild, neutral. Entries the Heart, Lung, Spleen, and Kidney meridians. [Functions and Indications] Diuresis and dampness removal, spleen strengthening, and tranquilizing the mind. Used for edema, oliguria, phlegm and fluid retention, dizziness and palpitations, spleen deficiency, poor appetite, loose stools and diarrhea, restlessness, palpitations, and insomnia.

[0023] Cimicifuga [Nature and Flavor and Meridians] Pungent, slightly sweet, slightly cold. It enters the Lung, Spleen, Stomach, and Large Intestine meridians. [Functions and Indications] It releases heat and clears rashes, clears heat and detoxifies, and raises Yang Qi. It is used for wind-heat headaches, toothaches, mouth sores, sore throats, measles that have not cleared up, rash caused by Yang poison, rectal prolapse, and uterine prolapse.

[0024] Compared with the prior art, the present invention has the following beneficial effects:

[0025] The present invention is based on the pathological and pathological theory of constipation in traditional Chinese medicine and the treatment experience in clinical practice, and continuously optimizes and forms a Chinese medicine prescription. Among them, Citrus aurantium promotes qi circulation and eliminates accumulation, and clears and descends intestinal qi; costus root promotes qi circulation and relieves pain, and eliminates food stagnation; costus root and Citrus aurantium are compatible, which promotes intestinal peristalsis and enhances intestinal qi circulation; euphorbia pulex soothes the liver and regulates qi, disperses stagnation and eliminates stagnation; vinegar-soaked angelica regulates qi and relieves depression, and harmonizes the liver and spleen; cinnamon twig warms yang and dredges the collaterals, and promotes the circulation of qi and blood; dried ginger warms the middle and dispels cold, and enhances spleen yang; tuckahoe strengthens the spleen and eliminates dampness, and helps transport water and grain; and cimicifuga raises clear yang to help the large intestine conduction. The Chinese medicine composition of the present invention has a reasonable compatibility, and each medicine works together, taking into account both clearing and moving, and has the effects of regulating qi and clearing the intestinal tract, warming yang and relieving constipation, strengthening the spleen and helping transport, and raising the clear and lowering the turbid, promoting the recovery of the normal intestinal conduction function, directly preventing constipation caused by intestinal qi stagnation in stroke patients, effectively preventing the occurrence of early constipation in stroke patients, and promoting the recovery of stroke.

[0026] The present invention takes regulating qi, dredge bowels, warm yang, strengthen spleen and harmonize ascending and descending as fundamental conditioning, is safe, has no side effects and has mild efficacy, and acupoint application can avoid the extra burden of oral medication on the spleen and stomach, is suitable for "prevention before illness", is easy to operate, and is easier for patients to accept, and is suitable for elderly stroke patients with a constitution of deficiency and stagnation. DETAILED DESCRIPTION

[0027] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0028] The invention provides a traditional Chinese medicine composition for preventing post-stroke constipation. The composition comprises the following raw materials in parts by weight: 12-15 parts of fructus aurantii, 9-12 parts of costus root, 10-15 parts of fructus euphorbiae, 6-8 parts of cassia twig, 10-12 parts of vinegar-soaked cyperus, 6-8 parts of dried ginger, 10-15 parts of poria cocos, and 3-5 parts of cimicifuga.

[0029] The present invention also provides a method for preparing a traditional Chinese medicine patch for preventing post-stroke constipation, comprising the following steps: weighing the above raw materials, processing them into powder, and passing them through a 50-250 mesh sieve to obtain fine powder; placing them in a container, mixing the fine powder raw materials, adding an application medium and blending them into a paste; taking the paste and spreading it in an application anti-seepage circle to obtain a traditional Chinese medicine patch.

[0030] In some embodiments, the application medium may be sesame oil, vinegar, honey, glycerin, rice wine, etc., and the mass ratio of the fine powder to the application medium is 1:(0.5-3).

[0031] In some embodiments, the paste is placed at 3-4° C. for standby use, and is then allowed to warm up at room temperature before use.

[0032] Example 1

[0033] A traditional Chinese medicine composition for preventing post-stroke constipation comprises the following raw materials in parts by weight: 12 parts of Citrus aurantium, 10 parts of Aucklandia lappa, 10 parts of Fructus sylvestris, 7 parts of Cinnamomum cassia, 10 parts of Cyperus rotundus with vinegar, 6 parts of dried ginger, 15 parts of Poria cocos, and 5 parts of Cimicifuga heracleifolia. The raw materials are weighed in proportion, processed into powder, and passed through an 80-mesh sieve to obtain a fine powder. The fine powders are placed in a container, mixed, and blended with sesame oil to form a paste, with the total weight ratio of the fine powders to the sesame oil being 1:1. The paste is spread on an anti-seepage ring of an application, which is 2*2 cm in size and approximately 0.3 cm thick, to obtain a traditional Chinese medicine application.

[0034] Example 2

[0035] A traditional Chinese medicine composition for preventing post-stroke constipation comprises the following raw materials in parts by weight: 13 parts of Citrus aurantium, 9 parts of Aucklandia lappa, 14 parts of Fructus sylvestris, 6 parts of Cinnamomum cassia, 11 parts of Cyperus rotundus with vinegar, 8 parts of dried ginger, 13 parts of Poria cocos, and 4 parts of Cimicifuga heracleifolia. The raw materials are weighed in proportion, processed into powder, and passed through an 80-mesh sieve to obtain a fine powder. The fine powders are placed in a container, mixed, and blended with sesame oil to form a paste, with the total weight ratio of the fine powders to the sesame oil being 1:1. The paste is then spread on an anti-seepage ring of a 2x2 cm (approximately 0.3 cm) anti-seepage ring to obtain a traditional Chinese medicine dressing.

[0036] Example 3

[0037] A traditional Chinese medicine composition for preventing post-stroke constipation comprises the following raw materials in parts by weight: 15 parts of Citrus aurantium, 12 parts of Aucklandia lappa, 12 parts of Fructus sylvestris, 8 parts of Cinnamomum cassia, 12 parts of Cyperus rotundus, 7 parts of dried ginger, 10 parts of Poria cocos, and 3 parts of Cimicifuga heracleifolia. The raw materials are weighed in proportion, processed into powder, and passed through an 80-mesh sieve to obtain a fine powder. The fine powders are placed in a container, mixed, and blended with sesame oil to form a paste, with the total weight ratio of the fine powders to the sesame oil being 1:1. The paste is spread on an anti-seepage ring of an application, which is 2*2 cm in size and approximately 0.3 cm thick, to obtain a traditional Chinese medicine application.

[0038] clinical trials

[0039] 1. General Information

[0040] Research subjects: 80 patients with cerebral stroke inpatients from the Department of Neurology, Ezhou Hospital of Traditional Chinese Medicine, Hubei Province from May 2021 to October 2022 were selected. A completely randomized controlled trial method was used to divide the patients into a treatment group and a control group, with 40 people in each group. There was no significant difference in age, gender, and course of disease between the two groups of patients, see Table 1. Inclusion criteria: ① Patients who meet the diagnostic criteria for stroke and have stable vital signs; ② Patients hospitalized within 3 days of onset; ③ Normal bowel movements before admission; ④ Actively cooperate with treatment and voluntarily participate in the study. Exclusion criteria: ① Patients with trauma or recent surgery; ② Malignant tumors, especially digestive system tumors; ③ Moderate to severe diabetes; ④ Severe liver and kidney dysfunction; ⑤ Myocardial infarction or angina pectoris; ⑥ Patients who need to fast; ⑦ Patients with diarrhea; ⑧ Patients with rectal and perianal lesions affecting bowel function.

[0041] Table 1 Comparison of general conditions of the two groups of patients

[0042]

[0043] 2. Nursing methods

[0044] The control group received conventional psychological care, dietary adjustments, anal contraction exercise guidance, and massage. In addition to the control group, the treatment group received the Chinese medicine composition of Example 1 applied to the Shenque acupoint once daily for 4-6 hours. The time of first defecation and daily bowel movement frequency were recorded for all patients for 7 consecutive days. The occurrence of constipation and adverse reactions were observed.

[0045] 3. Data analysis: The observed indicators were statistically analyzed, and the quantitative data were expressed as mean ± standard deviation. The time to first defecation and the occurrence of constipation in the treatment group and the control group were compared.

[0046] 4. Trial Results: Comparison of the time to first bowel movement between the two groups showed a statistically significant difference (p < 0.05), with the treatment group experiencing a shorter first bowel movement than the control group. The incidence of constipation also showed a statistically significant difference (p < 0.05). See Table 2. The diagnostic criteria for constipation in the "Standards for Diagnosis and Efficacy of Traditional Chinese Medicine Diseases and Syndromes" are as follows: ① Prolonged bowel movements, with bowel movements occurring more than once every three days, and dry, hard stools; ② In severe cases, stools are difficult, dry, and chestnut-like, and may be accompanied by abdominal distension and pain when pressed.

[0047] Table 2 Time to first defecation and occurrence of constipation in two groups of patients

[0048]

[0049] Patients in the treatment group had a shorter first bowel movement than those in the control group, with normal bowel movement frequency and stool shape, effortless defecation, and no constipation. Patients in the control group had a later first bowel movement and experienced constipation. These experimental results demonstrate that the traditional Chinese medicine composition of the present invention is more effective in preventing constipation in stroke patients than the control group, with no adverse reactions.

[0050] In summary, the Chinese medicine composition of the present invention has a reasonable compatibility, the various medicines work synergistically, and take into account both the function of promoting circulation and movement. It has the effects of regulating qi and relieving bowel movements, warming yang and relieving constipation, strengthening the spleen and assisting transportation, raising the clear and lowering the turbid, promoting the recovery of normal intestinal conduction function, directly targeting the core of intestinal qi blockage in stroke patients to prevent constipation, effectively preventing the occurrence of early constipation in stroke patients, and promoting recovery from stroke.

[0051] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine composition for preventing post-stroke constipation, characterized in that: The invention comprises the following raw materials in parts by weight: 12-15 parts of fructus aurantii, 9-12 parts of costus root, 10-15 parts of fructus cyperi, 6-8 parts of cassia twig, 10-12 parts of vinegar-cooked cyperus, 6-8 parts of dried ginger, 10-15 parts of poria and 3-5 parts of cimicifuga.

2. A Chinese medicine composition for preventing post-stroke constipation according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 12 parts of Citrus aurantium, 10 parts of costus root, 10 parts of euphorbia pulegosa, 7 parts of cinnamon twig, 10 parts of vinegar-cooked cyperus, 6 parts of dried ginger, 15 parts of Poria cocos and 5 parts of Cimicifuga heracleifolia.

3. A Chinese medicine composition for preventing post-stroke constipation according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 13 parts of Citrus aurantium, 9 parts of costus root, 14 parts of euphorbia pulegosa, 6 parts of cinnamon twig, 11 parts of vinegar-cooked cyperus, 8 parts of dried ginger, 13 parts of Poria cocos and 4 parts of Cimicifuga heracleifolia.

4. A Chinese medicine composition for preventing post-stroke constipation according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 15 parts of Citrus aurantium, 12 parts of costus root, 12 parts of euphorbia pulegosa, 8 parts of cinnamon twig, 12 parts of vinegar-soaked cyperus, 7 parts of dried ginger, 10 parts of Poria cocos and 3 parts of Cimicifuga heracleifolia.

5. A Chinese medicine patch for preventing post-stroke constipation, characterized in that: The invention relates to a Chinese medicine composition comprising the Chinese medicine composition according to any one of claims 1 to 4.

6. A Chinese medicine patch for preventing post-stroke constipation according to claim 5, characterized in that: The Chinese medicine patch is applied on the Shenque acupoint.

7. The method for preparing the Chinese medicine patch for preventing post-stroke constipation according to claim 5, characterized in that: The following steps are involved: A certain amount of raw materials are weighed, processed into powder, and passed through a 50-250 mesh sieve to obtain fine powder; the raw materials are put into a container, the fine powder is mixed, and the dressing medium is added to form a paste; the paste is spread in the dressing anti-seepage circle to obtain a traditional Chinese medicine dressing.

8. The method for preparing the Chinese medicine patch for preventing post-stroke constipation according to claim 7, characterized in that: The application medium is at least one of sesame oil, vinegar, honey, glycerin, and rice wine, and the mass ratio of the fine powder to the application medium is 1:(0.5-3).

9. The method for preparing the Chinese medicine patch for preventing post-stroke constipation according to claim 8, characterized in that: The application medium is sesame oil, and the mass ratio of the fine powder to the application medium is 1:

1.

10. The method for preparing the Chinese medicine patch for preventing post-stroke constipation according to claim 7, characterized in that: The paste is placed at 3-4°C for later use and returned to temperature before use.

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