Hydrogen-tea polyphenol supramolecular composite composition

Abstract

The invention discloses a hydrogen-tea polyphenol supramolecular composite composition, and belongs to the technical field of large health products. The composition comprises: 0.5%-1.2% of a hydrogen-tea polyphenol supramolecular compound, wherein electrolytic hydrogen and tea polyphenol form a supramolecular structure under a high pressure of 300-500 MPa; oSA is used for modifying a tea polyphenol steady-state carrier (0.05%-0.15%), and octenyl succinic anhydride is used for grafting to improve the stability; the hydrogen molecule sustained-release capsule (0.1%-0.3%) is used for realizing in-situ hydrogen production by using beta-cyclodextrin to include hydrogen and containing IrO2 and CeO2 as a catalyst; and the balance is a medicinal or edible carrier. Through triple technologies of supramolecular compounding, chemical modification and catalytic hydrogen production, the problems that hydrogen is easy to escape and tea polyphenol is easy to degrade are synergistically solved, efficient, stable and long-acting slow release of double active components is realized, the antioxidant synergistic effect and bioavailability are remarkably improved, and the tea polyphenol-modified supramolecular composite material is suitable for the fields of functional beverages, skin care products, health care products and the like.

Description

Technical Field

[0001] The present invention relates to the technical field of health products, in particular to a hydrogen-tea polyphenol supramolecular composite composition. Background Art

[0002] Excessive accumulation of reactive oxygen species (ROS) is a contributing factor to aging and various diseases, and exogenous supplementation of antioxidants is crucial. Hydrogen molecules (H2) have selective antioxidant properties and can accurately remove toxic free radicals (such as ·OH), but due to their extremely low water solubility and easy dissipation, they are difficult to store and use stably. As a broad-spectrum antioxidant, tea polyphenols have defects such as unstable chemical properties (easy to be oxidized and inactivated) and low bioavailability. Existing technologies (such as microcapsules) are mostly targeted at a single ingredient and cannot simultaneously solve the stability and synergistic delivery problems of hydrogen and tea polyphenols. Simply mixing the two is prone to accelerated degradation, and the lack of a long-term controlled-release mechanism results in a short-lived product effect. Therefore, there is an urgent need for an innovative technical solution that can synergistically stabilize hydrogen and tea polyphenols and achieve long-term release. Summary of the Invention

[0003] In view of the above situation, it is necessary to provide a hydrogen-tea polyphenol supramolecular composite composition that solves at least one of the above problems, which comprises the following components by weight percentage:

[0004] a) 0.5% to 1.2% hydrogen-tea polyphenol supramolecular complex;

[0005] b) 0.05% to 0.15% of a tea polyphenol stable carrier modified with octenylsuccinic anhydride (OSA), wherein the degree of substitution of OSA on tea polyphenol is 0.03 to 0.05;

[0006] c) 0.1% to 0.3% molecular hydrogen sustained-release capsules;

[0007] d) the balance is a pharmaceutically or food acceptable carrier.

[0008] In a preferred embodiment of the present invention, the hydrogen-tea polyphenol supramolecular complex is a supramolecular structure formed by combining electrolytic hydrogen with tea polyphenols under pressure conditions of 300 MPa to 500 MPa. This process utilizes ultra-high pressure physical effects to induce the formation of non-covalent bonds (such as hydrogen bonds and van der Waals forces), "anchoring" the easily dissipative hydrogen molecules in a specific spatial conformation of the tea polyphenol molecules. This supramolecular structure not only significantly increases hydrogen loading and stability, but also protects the phenolic hydroxyl activity of the tea polyphenols through close intermolecular interactions, forming a first-level sustained-release and stabilization system.

[0009] In another preferred embodiment of the present invention, the tea polyphenols used to prepare the supramolecular complex are extracted using deep eutectic solvents (DES). DES, as a new type of green solvent, is formed by mixing hydrogen bond acceptors (such as quaternary ammonium salts) and hydrogen bond donors (such as polyols and organic acids) in a specific molar ratio. It has the advantages of low vapor pressure, high solubility, flexible design, and biodegradability. Compared with traditional organic solvents, the use of DES to extract tea polyphenols can preserve its molecular structure and biological activity more gently and efficiently, avoid organic solvent residues, and provide high-quality raw materials for subsequent high-pressure compounding.

[0010] In another preferred embodiment of the present invention, the OSA-modified tea polyphenol stable carrier is formed by grafting octenyl succinic anhydride onto the tea polyphenol molecule through an esterification reaction. One end of the OSA molecule is a lipophilic octenyl long chain, and the other end is a carboxyl group after the hydrophilic succinic anhydride is opened. Through the esterification reaction, OSA is grafted onto the phenolic hydroxyl group or alcoholic hydroxyl group of the tea polyphenol, thereby introducing a group with both lipophilic and hydrophilic properties on the tea polyphenol molecule. By precisely controlling the degree of substitution (DS) between 0.03 and 0.05, its amphiphilicity can be optimized so that it forms stable micelles in the aqueous phase or plays an emulsifying role at the oil / water interface. This not only greatly improves the dispersibility and stability of tea polyphenols in complex formula systems (such as emulsions and gels), resists the effects of light, heat, and pH fluctuations, but also because of its lipophilicity, it can promote the interaction between tea polyphenols and cell membranes, improve its transmembrane absorption efficiency, and achieve secondary stability and targeted delivery.

[0011] In another preferred embodiment of the present invention, the structure of the hydrogen molecule sustained-release capsule is an inclusion complex formed by enclosing hydrogen molecules with β-cyclodextrin as the wall material. β-cyclodextrin is a cyclic oligosaccharide composed of 7 glucose units, and its molecular structure presents a conical hollow cylinder with "hydrophilic outside and hydrophobic inside". Its hydrophobic inner cavity can accommodate guest molecules of appropriate size (such as hydrogen molecules), and form a stable inclusion complex through non-covalent bonds such as van der Waals forces. This inclusion complex physically confines the hydrogen molecules in the cavity, effectively preventing them from escaping, and forming a second hydrogen storage and sustained-release mechanism.

[0012] In another preferred embodiment of the present invention, in order to achieve "in situ, on-demand" supply of hydrogen, the hydrogen molecule sustained-release capsule also creatively contains an IrO2@CeO2 core-shell structure catalyst for in situ electrolysis of water to produce hydrogen molecules. This is a cutting-edge nanocatalytic technology. When the capsule enters the aqueous environment, a trace amount of water molecules penetrates in, and the efficient catalyst can electrolyze water at an extremely low potential (which can be triggered by the micropotential of other components in the system or external energy) to continuously produce hydrogen. Part of the generated hydrogen is captured by the β-cyclodextrin cavity to achieve slow release, and part is directly replenished into the system. This design fundamentally solves the problem of hydrogen pre-storage, turning the product into a miniature "hydrogen generator" and achieving unprecedented long-term hydrogen supply.

[0013] In another preferred embodiment of the present invention, the IrO2@CeO2 core-shell structure catalyst has specific structural advantages. Among them, CeO2 (cerium dioxide) as a carrier, itself has excellent oxygen storage / release capacity and chemical stability, can provide a stable platform for catalysis and cooperate with the catalytic process. IrO2 (iridium dioxide) as the active site for oxygen / hydrogen production by electrolysis of water is highly dispersedly loaded on the surface of the CeO2 carrier to form a core (CeO2)-shell (IrO2) or loaded structure. This design not only maximizes the atomic utilization of the precious metal Ir and reduces costs, but also significantly improves the activity and durability of the catalyst through electronic interactions between the core-shell interface, ensuring that it can work continuously and stably during the product's shelf life.

[0014] In order to meet the needs of different application scenarios, the composition of the present invention may further include functional excipients.

[0015] In a preferred embodiment, the composition further comprises 0.01% to 0.05% by weight of isododecane. Isododecane is a highly branched alkane with excellent spreadability, a refreshing, non-greasy feel, and good solubility. In skincare applications, it acts as an oil phase regulator, significantly improving the product's spreadability and adding a silky texture. It also serves as a solubility aid for fat-soluble ingredients such as OSA and tea polyphenols.

[0016] In another preferred embodiment, it further comprises 2% to 5% by weight of oligofructose (FOS). Oligofructose is a recognized prebiotic that cannot be directly digested and absorbed by the human body, but can be utilized by beneficial bacteria in the intestine (such as Bifidobacterium) to promote their proliferation, thereby regulating the balance of intestinal flora and playing a role in improving digestion and enhancing immunity. Adding FOS to functional foods or health products can not only synergize with hydrogen and tea polyphenols to regulate intestinal health, but also act as a sweetener and thickener to improve the taste and texture of the product.

[0017] The carrier used in the present invention is a pharmaceutically or food-acceptable carrier, preferably ultrapure water. Ultrapure water removes impurities such as ions, organic matter, and microorganisms, thereby minimizing interference with the stability of the active ingredients and the formulation system.

[0018] 3. Beneficial Effects

[0019] Compared with the prior art, the present invention has achieved the following significant beneficial effects through the above creative combination design:

[0020] Synergistic Antioxidant Capacity: This invention organically combines a selective antioxidant (hydrogen molecules) with a broad-spectrum antioxidant (tea polyphenols). Hydrogen molecules precisely scavenge the most toxic ·OH radical, while tea polyphenols scavenge other free radicals and inhibit oxidation. The two coexist in a supramolecular complex, creating a synergistic effect when acting on the same target. Their combined antioxidant capacity far exceeds the linear sum of their individual components.

[0021] Multi-dimensional, multi-stage long-term controlled release: This invention has created the unique mechanisms of "dual-channel hydrogen supply" and "double-stabilization of tea polyphenols".

[0022] Controlled Hydrogen Release: A hydrogen-tea polyphenol supramolecular complex provides a first level of sustained release, with hydrogen and tea polyphenols released simultaneously. A second, longer-lasting background hydrogen supply is achieved through β-cyclodextrin inclusion and in-situ catalytic hydrogen production capsules. This design ensures a continuous supply of effective hydrogen concentrations throughout the product's lifecycle and even after entry into the body.

[0023] Controlled release and stabilization of tea polyphenols: By protecting some of its active groups through supramolecular complexes and through OSA chemical modification, its physicochemical stability and biocompatibility are fundamentally improved. This allows tea polyphenols to maintain high activity in complex environments.

[0024] High Component Stability: This multi-protection system effectively addresses the core challenges of hydrogen dissipation and tea polyphenol degradation. The supramolecular structure, OSA modification, and cyclodextrin inclusion act as three lines of defense, ensuring the high stability of the active ingredients during production, storage, transportation, and use, significantly extending the product's shelf life and efficacy.

[0025] Improved bioavailability and targeting: OSA modification imparts amphiphilicity to tea polyphenols, improving their dispersion and absorption in the gastrointestinal tract or the stratum corneum of the skin, helping to more efficiently deliver the active ingredients to the site of action. This type of targeting is unmatched by simple mixtures.

[0026] High safety and wide application potential: The in-situ hydrogen generation technology employed in this invention avoids the safety hazards associated with high-pressure hydrogen storage, allowing hydrogen-containing products to enter the market safely as common consumer goods. All components of the entire formulation exhibit excellent biocompatibility, and by adjusting the functional excipients, the product can be flexibly applied to a variety of dosage forms, including functional beverages, oral health supplements, anti-aging serums, and repair masks, promising broad market applications. DETAILED DESCRIPTION

[0027] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0028] In the description of the present invention, unless otherwise specified, "plurality" means two or more; the terms "center", "longitudinal", "lateral", "upper", "lower", "left", "right", "inner", "outer", "front end", "rear end", "head", "tail", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operate in a specific orientation, and therefore should not be understood as limiting the present invention. In addition, the terms "first", "second", "third", etc. are used for descriptive purposes only and should not be understood as indicating or implying relative importance.

[0029] In the description of the present invention, it should be noted that, unless otherwise specified or limited, the terms "mounted," "connected," and "connected" should be understood in a broad sense. For example, they can refer to fixed connections, detachable connections, or integral connections; mechanical connections, electrical connections; direct connections, indirect connections through an intermediate medium, and internal connections between two components. Those skilled in the art will understand the specific meanings of the above terms in this application based on specific circumstances.

[0030] The present invention will be further described in detail below in conjunction with specific examples. However, it should be understood that these examples are intended only to illustrate the present invention and are not intended to limit the scope of the present invention. Various non-substantial modifications and adjustments to the method, steps, or conditions of the present invention, without departing from the spirit and substance of the present invention, remain within the scope of protection of the present invention.

[0031] Unless otherwise specified, the reagents used in the examples are all commercially available products of analytical grade or higher, and the equipment used are all conventional equipment in the art.

[0032] Example 1: Preparation of antioxidant and repair functional beverage

[0033] 1. Recipe

[0034] Hydrogen-tea polyphenol supramolecular complex: 1.0%

[0035] OSA-tea polyphenols stable carrier (DS=0.04): 0.1%

[0036] Hydrogen molecule sustained-release capsules: 0.2%

[0037] Fructooligosaccharides: 4.0%

[0038] Citric acid: 0.05% (pH adjuster)

[0039] Natural fruit flavor: 0.1%

[0040] Ultrapure water: add to 100%

[0041] 2. Preparation of Components

[0042] a) Extraction of Tea Polyphenols with DES: Choline chloride and glycerol were weighed and placed in a reaction vessel. Stir and heat at 80°C until a homogeneous, transparent liquid was formed. After cooling, a deep eutectic solvent (DES) with a molar ratio of 1:2 was obtained. Pulverized green tea leaf powder was mixed with DES at a solid-liquid ratio of 1:20, and ultrasonic-assisted extraction was performed at 60°C for 60 minutes. The extract was centrifuged at high speed, filtered through a 0.45μm membrane, and then adsorbed and desorbed on a macroporous resin. Finally, vacuum freeze-dried to obtain a pale yellow powder with a tea polyphenol purity of >95%.

[0043] b) Preparation of hydrogen-tea polyphenol supramolecular complex: The tea polyphenol powder obtained in step a) is dissolved in ultrapure water to prepare a 5% solution. The solution is placed in a material tank of an ultra-high pressure homogenizer (model: AH-BASIC, ATS Engineering Inc.) equipped with an electrolysis device. Turn on the electrolysis device, introduce inert gas (nitrogen) to remove the air in the system, and electrolyze water to produce hydrogen. At the same time, start the high-pressure pump, set the homogenization pressure to 400 MPa, and circulate the process for 30 minutes. Under the action of high pressure and shear force, hydrogen molecules and tea polyphenols form supramolecular complexes. The obtained suspension is freeze-dried to obtain hydrogen-tea polyphenol supramolecular complex powder.

[0044] c) Preparation of OSA-tea polyphenols stable carrier: Weigh the tea polyphenols powder obtained in step a) and dissolve it in DMSO (dimethyl sulfoxide). Under nitrogen protection and ice bath conditions, slowly add octenylsuccinic anhydride (OSA) DMSO solution (the molar ratio of tea polyphenols to OSA is 1:0.5). After the addition is complete, warm to room temperature and react for 24 hours. After the reaction is completed, pour the reaction solution into a large amount of ethanol for precipitation, and collect the precipitate by centrifugation. The precipitate is washed repeatedly with ethanol three times to remove unreacted OSA and DMSO, and finally dried in vacuum to obtain OSA-tea polyphenols stable carrier powder. By nuclear magnetic resonance hydrogen spectrum ( 1 H NMR) calculations determined the degree of substitution (DS) to be approximately 0.04.

[0045] d) Preparation of hydrogen molecule sustained-release capsules:

[0046] d1. Synthesis of IrO2@CeO2 Core-Shell Catalyst: Spherical CeO2 nanoparticles were prepared as cores using a hydrothermal method. The CeO2 nanoparticles were then dispersed in a H2IrCl6 (chloroiridic acid) solution using an impregnation-calcination method. After adsorption with stirring, the mixture was filtered, dried, and calcined in air at 350°C for 2 hours to obtain a core-shell catalyst with highly dispersed IrO2 supported on the CeO2 surface.

[0047] d2. Inclusion and encapsulation: Dissolve β-cyclodextrin in water to form a saturated solution. Add the IrO2@CeO2 catalyst powder (accounting for 1% of the weight of β-cyclodextrin) prepared in step d1) to the solution and disperse it evenly by ultrasonication. Place the mixed solution in a sealed high-pressure reactor, introduce high-purity hydrogen to 2MPa, and vigorously stir at 25°C for 24 hours to allow the hydrogen molecules to fully enter the cavity of β-cyclodextrin. After the reaction is completed, the solution is quickly spray-dried or freeze-dried to obtain a hydrogen molecule sustained-release capsule powder containing both included hydrogen and a hydrogen production catalyst.

[0048] Preparation of functional drinks

[0049] Dissolve the formulated amount of oligofructose and citric acid in 80% of the total volume of ultrapure water and stir until completely dissolved. Slowly add the formulated amount of hydrogen-tea polyphenol supramolecular complex powder, OSA-tea polyphenol stable carrier powder, and hydrogen molecule sustained-release capsule powder in sequence under high-speed shear stirring. Continue shear emulsification for 20 minutes until a uniform and stable dispersion is formed. Finally, add natural fruit flavoring, dilute to 100% with ultrapure water, and aseptically fill to obtain the finished product.

[0050] Example 2: Preparation of anti-aging repair essence

[0051] formula

[0052] Hydrogen-tea polyphenol supramolecular complex: 1.2%

[0053] OSA-tea polyphenols stable carrier (DS=0.05): 0.15%

[0054] Hydrogen molecule sustained-release capsules: 0.3%

[0055] Isododecane: 0.05%

[0056] Sodium hyaluronate (1% aqueous solution): 10.0%

[0057] Glycerin: 5.0%

[0058] 1,3-Butanediol: 3.0%

[0059] Phenoxyethanol / Ethylhexylglycerin: 0.8% (preservative)

[0060] Ultrapure water: add to 100%

[0061] Preparation method

[0062] Phase A (aqueous phase): Dissolve glycerol, 1,3-butylene glycol and preservative in ultrapure water, heat to 80°C and stir well.

[0063] Phase B (functional phase): Mix the formulated amount of hydrogen-tea polyphenol supramolecular complex (prepared by the same method as in Example 1), OSA-tea polyphenol stable carrier (prepared by the same method as in Example 1, and adjust the reaction material ratio to make DS≈0.05), hydrogen molecule sustained-release capsule (prepared by the same method as in Example 1) and isododecane, and pre-disperse them evenly.

[0064] Phase C (thickening phase): 1% sodium hyaluronate aqueous solution.

[0065] Emulsification: Slowly add phase B into phase A and homogenize at 8000 rpm for 5 minutes using a high-speed homogenizer.

[0066] Cooling and finishing: Cool the emulsified material to below 40°C, add phase C and the remaining water, and stir evenly to obtain the finished anti-aging repair essence.

[0067] Example 3: Preparation of intestinal health prebiotic solid beverage

[0068] formula

[0069] Hydrogen-tea polyphenol supramolecular complex: 0.8%

[0070] OSA-tea polyphenols stable carrier (DS=0.03): 0.08%

[0071] Hydrogen molecule sustained-release capsules: 0.15%

[0072] Fructooligosaccharides: 90.0%

[0073] Inulin: 8.74%

[0074] Silicon dioxide: 0.2% (anti-caking agent)

[0075] Preparation method

[0076] The three core functional component powders prepared in Example 1 (hydrogen-tea polyphenol supramolecular complex, OSA-tea polyphenol stable carrier, and hydrogen molecule sustained-release capsules) were placed in a V-type mixer with oligofructose powder, inulin, and silicon dioxide and mixed for 30 minutes until uniform. The mixture was then packaged into individual small bags (10 g per bag) using a fully automatic packaging machine to obtain the finished product.

[0077] Test example

[0078] In order to demonstrate the beneficial effects of the composition of the present invention, we conducted the following comparative tests.

[0079] Test sample:

[0080] Sample of the present invention: the antioxidant repair functional beverage prepared in Example 1.

[0081] Comparative Example 1: The three core functional components in Example 1 were replaced with equal amounts of ordinary green tea extract powder (with the same tea polyphenol content as the sample of the present invention) and ordinary hydrogen-rich water (prepared using a hydrogen generator with an initial hydrogen concentration of 1.6 ppm). The other components and preparation methods were the same.

[0082] Comparative Example 2: The three core functional components in Example 1 were replaced with a simple physical mixture: tea polyphenol powder that had not been subjected to high pressure treatment, tea polyphenol powder that had not been modified with OSA, and capsules containing only hydrogen gas encapsulated with β-cyclodextrin (without a catalyst). The content of each component was the same as that of the present invention.

[0083] Test Example 1: Stability Test

[0084] The three samples were stored at 40°C under illumination (4500 Lux) for 30 days. Samples were collected on days 0, 7, 15, and 30 for determination of tea polyphenol content using high-performance liquid chromatography (HPLC). The hydrogen concentration in the headspace of the sealed container (an indirect reflection of the solution's hydrogen retention capacity) was measured using gas chromatography (GC) or a high-precision hydrogen analyzer.

[0085] Results: As shown in Table 1.

[0086]

[0087]

[0088] Table 1: Active ingredient retention rate under accelerated conditions (%)

[0089] Conclusion: The data show that the tea polyphenols and hydrogen in the samples of the present invention exhibit extremely high stability, with retention rates of approximately 90% after 30 days. In contrast, Comparative Example 1 (simple mixing) suffered severe losses of active ingredients, with hydrogen almost completely dissipating within 7 days and tea polyphenols also severely degraded. While Comparative Example 2 (a partial technical combination) was superior to Comparative Example 1, its stability was far inferior to that of the present invention. This fully demonstrates the tremendous advantage of the present invention's unique "supramolecular composite + OSA modification + catalytic hydrogen production capsule" synergistic system in stabilizing active ingredients.

[0090] Test Example 2: In vitro antioxidant capacity test (DPPH free radical scavenging ability)

[0091] The DPPH method was used to determine the free radical scavenging ability of the samples. The results were expressed as IC 50 The value (i.e., the sample concentration required to scaveng 50% of DPPH free radicals) indicates that the IC 50 The smaller the value, the stronger the antioxidant capacity.

[0092] Table 2: DPPH free radical scavenging ability of samples (IC 50 ,mg / mL)

[0093]

[0094]

[0095] Table 2: DPPH free radical scavenging ability of samples (IC 50 ,mg / mL)

[0096] *Note: The concentration of tea polyphenols is consistent with that of the sample of the present invention.

[0097] Conclusion: IC of the samples of the present invention 50 The value is significantly lower than that of all comparative examples, indicating that it has the strongest in vitro antioxidant activity. Its activity is much higher than that of the tea polyphenol solution alone, and is also better than the simple mixture (Comparative Example 1) and some technical combinations (Comparative Example 2), demonstrating the synergistic effect of hydrogen and tea polyphenols in the system of the present invention.

[0098] Test Example 3: Hydrogen slow-release performance test

[0099] The sample of the present invention and equal amounts of samples of Comparative Examples 1 and 2 were placed in sealed containers, respectively, and the dissolved hydrogen concentration in the solution was continuously monitored at 37°C.

[0100] Results: The hydrogen concentration of Comparative Example 1 dropped rapidly from 1.6 ppm to below 0.2 ppm within 1 hour. The hydrogen concentration of Comparative Example 2 dropped slowly within the first 4 hours, and then stabilized but remained at a low level. The hydrogen concentration of the sample of the present invention remained at a high level within the first 2 hours (due to the release of hydrogen from the supramolecular complex and inclusion complex). Although it slowly dropped thereafter, it was still able to maintain an effective concentration significantly higher than the baseline level (e.g., >0.5 ppm) during the 12-hour or even 24-hour monitoring period due to the continued action of in-situ catalytic hydrogen production.

[0101] Conclusion: The dual-channel hydrogen supply system of the present invention successfully achieves long-term and continuous release of hydrogen, solving the fundamental problem of short hydrogen action time in the prior art.

[0102] In summary, the present invention successfully constructs a stable, efficient and long-lasting hydrogen-tea polyphenols delivery system through sophisticated formula design and the organic integration of multiple cutting-edge technologies. Its technical effect is significantly better than the existing technology and has extremely high industrial application value.

[0103] The above description is only a preferred embodiment of the present invention and is not intended to limit the scope of protection of the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included in the scope of protection of the present invention.

Claims

1. A hydrogen-tea polyphenol supramolecular composite composition, characterized in that: By weight percentage, it comprises the following components: a) 0.5% to 1.2% hydrogen-tea polyphenol supramolecular complex; b) 0.05% to 0.15% of a tea polyphenol stable carrier modified with octenyl succinic anhydride (OSA), wherein the degree of substitution of the tea polyphenols by OSA is 0.03 to 0.05; c) 0.1% to 0.3% molecular hydrogen sustained-release capsules; d) the balance is a pharmaceutically or food acceptable carrier.

2. The composition according to claim 1, characterized in that The hydrogen-tea polyphenol supramolecular complex is a supramolecular structure formed by combining electrolytic hydrogen with tea polyphenol under a pressure condition of 300 MPa to 500 MPa.

3. The composition according to claim 2, characterized in that The tea polyphenols are obtained by extraction using a deep eutectic solvent (DES).

4. The composition according to claim 1, characterized in that The OSA-modified tea polyphenol stable carrier is formed by grafting octenyl succinic anhydride onto tea polyphenol molecules through an esterification reaction.

5. The composition according to claim 1, characterized in that The structure of the hydrogen molecule sustained-release capsule is an inclusion compound formed by enclosing hydrogen molecules using beta-cyclodextrin as a wall material.

6. The composition according to claim 5, characterized in that The hydrogen molecule sustained-release capsule also contains an IrO2@CeO2 core-shell structure catalyst for in-situ electrolysis of water to generate hydrogen molecules.

7. The composition according to claim 6, characterized in that In the IrO2@CeO2 core-shell structure catalyst, CeO2 is a carrier and IrO2 is an active site loaded thereon.

8. The composition according to claim 1, characterized in that It also contains 0.01 to 0.05% by weight of isododecane.

9. The composition according to claim 1, characterized in that It also contains 2 to 5% by weight of oligofructose.

Images