Centella asiatica composition with soothing effect as well as preparation method and application of centella asiatica composition

Abstract

The invention discloses a centella asiatica composition with a soothing effect. The centella asiatica composition is prepared from the following raw materials in percentage by weight: 12 to 22 percent of plant extract, 10 to 31 percent of polyhydric alcohol, 0.1 to 1 percent of preservative and the balance of deionized water. The herba centellae extract, the herba artemisiae annuae extract, the white willow bark extract, the radix polygoni multiflori extract and the herba portulacae extract are combined, and the prepared composition has a soothing effect on facial skin and scalp and has a night repairing effect. In addition, under the optimal weight ratio, the composition has good formula compatibility, and can be stably stored when being applied to scalp care products.

Description

Technical Field

[0001] The present invention relates to the field of cosmetics, and in particular to a Centella asiatica composition with soothing effects, a preparation method and an application thereof. Background Art

[0002] As stress levels rise, people's facial skin and scalp are left with stubborn dust after a day's workday. This stress also leaves the skin and scalp in poor condition, causing them to automatically enter a repair phase at night. However, relying solely on the skin's own repair process cannot restore it to its normal state. Therefore, developing a serum with soothing properties can further improve nighttime repair. However, existing serums offer poor transdermal absorption while repairing, which can actually cause skin stress. Therefore, developing a serum with excellent transdermal absorption that can significantly enhance nighttime repair is crucial.

[0003] Chinese invention patent application CN118021695A discloses a soothing and dyeing hair care composition, its preparation method, and its use. The composition incorporates certain amounts of Portulaca oleracea extract, Salvia miltiorrhiza root extract, and Centella asiatica extract to enhance hair care during the dyeing process and further enhance the soothing effect. However, the composition comprises a large number of components and a complex production process. Chinese invention patent CN118021689B discloses a scalp microecological regulation and hair loss prevention composition, its preparation method, its use, and its cosmetics. The composition uses a plant fermentation filtrate, a filtrate obtained from yeast fermentation of plant powder, as a safe, mild, and non-irritating composition. It also regulates the scalp microecology, but its anti-allergic and soothing effects are suboptimal. Summary of the Invention

[0004] In order to develop an essence with good transdermal absorption and significantly improved nighttime repair effect, the first aspect of the present invention provides a Centella asiatica composition with a soothing effect. The preparation raw materials include, by weight percentage, 12-22% plant extract, 10-31% polyol, 0.1-1% preservative and deionized water supplemented to 100%.

[0005] As an embodiment, the plant extract includes an anti-inflammatory extract and an antioxidant extract, (9.05-17): (3-5).

[0006] As an embodiment, the anti-inflammatory extract includes at least Centella asiatica extract and Artemisia annua extract.

[0007] As an embodiment, the mass fraction of madecassoside in the Centella asiatica extract is 85-95 wt%.

[0008] As an embodiment, the mass fraction of madecassoside in the Centella asiatica extract is 90 wt%.

[0009] As an embodiment, the anti-inflammatory extract further comprises white willow bark extract and purslane extract.

[0010] As an embodiment, the antioxidant extract includes at least one of Polygonum multiflorum extract, Platycladus orientalis leaf extract, Zingiber officinale extract, and Eclalphia chinensis extract.

[0011] As an embodiment, the antioxidant extract is a Polygonum multiflorum extract.

[0012] As an embodiment, the plant extracts include Centella asiatica extract, Artemisia annua extract, Salix alba bark extract, Polygonum multiflorum extract and Portulaca oleracea extract.

[0013] As an embodiment, the weight ratio of the Centella asiatica extract, Artemisia annua extract, Salix alba bark extract, Polygonum multiflorum extract and Portulaca oleracea extract is (0.05-2):(3-5):(3-5):(3-5):(3-5).

[0014] As an embodiment, the weight ratio of the Centella asiatica extract, Artemisia annua extract, Salix alba bark extract, Polygonum multiflorum extract and Portulaca oleracea extract is (0.05-1):(3-5):(3-5):(3-5):(3-5).

[0015] As an embodiment, the weight ratio of the Centella asiatica extract, Artemisia annua extract, Salix alba bark extract, Polygonum multiflorum extract and Portulaca oleracea extract is 0.05:3:3:3:3.

[0016] As an embodiment, the weight ratio of the Centella asiatica extract, Artemisia annua extract, Salix alba bark extract, Polygonum multiflorum extract and Portulaca oleracea extract is 0.05:4:4:4:4.

[0017] As an embodiment, the weight ratio of the Centella asiatica extract, Artemisia annua extract, Salix alba bark extract, Polygonum multiflorum extract and Portulaca oleracea extract is 0.05:5:5:5:5.

[0018] As an embodiment, the weight ratio of the Centella asiatica extract, Artemisia annua extract, Salix alba bark extract, Polygonum multiflorum extract and Portulaca oleracea extract is 1:3:4:5:4.

[0019] During experiments, the inventors discovered that combining Centella asiatica, Artemisia annua, Willow bark, and Portulaca oleracea with Polygonum multiflorum can enhance the soothing effect of the composition. This effect can be further enhanced by applying it to a scalp serum at night, significantly improving the soothing and repairing properties. Polygonum multiflorum extract alone has poor transdermal penetration into the skin and scalp, potentially causing stress on the skin and scalp. Incorporating anti-inflammatory extracts further enhances the soothing and repairing effects and improves the transdermal absorption of Polygonum multiflorum, allowing it to remain on the scalp surface for a longer period of time. This enhances the user experience of the scalp serum and provides a soothing and repairing effect on the scalp, while being safe and non-irritating.

[0020] The inventors further discovered that the Centella asiatica extract, Artemisia annua extract, Salix alba bark extract, Polygonum multiflorum extract, and Portulaca oleracea extract need to be in an optimal weight ratio to obtain a stable composition so that it can be used in a scalp essence. If the weight ratio is not optimal, the composition will experience flocculation problems, affecting the stability of the product.

[0021] As an embodiment, the polyol includes at least one of butanediol, hexanediol, propylene glycol or ethylene glycol.

[0022] As an embodiment, the polyol includes butanediol and 1,2-hexanediol.

[0023] As an embodiment, the weight ratio of butanediol to 1,2-hexanediol is (10-30):0.5.

[0024] As an embodiment, the weight ratio of butanediol to 1,2-hexanediol is (10-20):0.5.

[0025] As an embodiment, the preservative is p-hydroxyacetophenone.

[0026] A second aspect of the present invention provides a method for preparing a Centella asiatica composition having a soothing effect, comprising the following steps:

[0027] Mixing the Centella asiatica extract and butylene glycol with stirring at room temperature to obtain a mixture A;

[0028] Add the preservative to hexylene glycol and dissolve it by stirring at 60-90°C, and mix it with mixture A to obtain mixture B;

[0029] The remaining anti-inflammatory extract and antioxidant extract are added to the mixture B and mixed evenly with deionized water to obtain a Centella asiatica composition with a soothing effect.

[0030] A third aspect of the present invention provides a scalp essence, the raw materials for preparing which include the above-mentioned Centella asiatica composition having a soothing effect.

[0031] As an embodiment, the raw materials for preparing the scalp essence include, by weight percentage, 1-10% of the Centella asiatica composition with a soothing effect, 40-45% of an auxiliary agent, and deionized water supplemented to 100%.

[0032] As an embodiment, the raw materials for preparing the scalp essence include, by weight percentage, 1-10% of a Centella asiatica composition with a soothing effect, 0.1% of disodium EDTA, 0.3% of dipotassium glycyrrhizate, 0.8% of hydrogenated starch hydrolysate, 0.03% of citric acid; 0.72% of phenoxyethanol, 0.08% of ethylhexylglycerin, 0.03% of fragrance, 20% of ethanol, 0.1% of PEG-40 hydrogenated castor oil, and deionized water supplemented to 100%.

[0033] A fourth aspect of the present invention provides a method for preparing a scalp essence, comprising the following steps: mixing a Centella asiatica composition having a soothing effect with an adjuvant and deionized water to obtain the scalp essence.

[0034] As an embodiment, the preparation method of the scalp essence comprises the following steps:

[0035] Mix dipotassium glycyrrhizate, disodium EDTA and deionized water evenly;

[0036] Then add phenoxyethanol, ethylhexylglycerin and hydrogenated starch hydrolysate and mix well;

[0037] Finally, citric acid, PEG-40 hydrogenated castor oil, ethanol, essence and the soothing Centella asiatica composition are added and mixed evenly to obtain a scalp essence.

[0038] Compared with the prior art, the present invention has the following beneficial effects:

[0039] (1) The soothing Centella asiatica composition of the present invention is prepared by combining Centella asiatica extract, Artemisia annua extract, Salix alba bark extract, Polygonum multiflorum extract and Portulaca oleracea extract. The composition has a soothing effect on facial skin and scalp, and has a nighttime repair effect.

[0040] (2) The soothing Centella asiatica composition of the present invention comprises Centella asiatica extract, Artemisia annua extract, Salix alba bark extract, Polygonum multiflorum extract and Portulaca oleracea extract in a preferred weight ratio, has good formula compatibility, and can be stably stored when applied to scalp care products.

[0041] (3) The soothing Centella asiatica composition of the present invention can be used in scalp essence to play a role in nighttime repair, effectively reduce skin inflammation, relieve redness, swelling and irritation, and various active ingredients work together to stay on the scalp surface for a long time to exert their effects, thereby extending the duration of action of the essence.

[0042] (4) The soothing Centella asiatica composition of the present invention is applied to scalp essence, which provides soothing and repairing effects to the scalp. At the same time, by supplementing lipids and moisturizing ingredients, the night repair product can repair the damaged skin barrier and enhance the skin's self-protection ability. It does not contain irritating ingredients, thereby improving the user experience of the scalp essence and being safe and non-irritating.

[0043] (5) The soothing Centella asiatica composition of the present invention is applied to scalp essence, can be stably stored in high and low temperature environments, is less likely to form flocs, and has good weather resistance.

[0044] (6) The soothing Centella asiatica composition of the present invention is applied to scalp essence, which can accelerate the repair and regeneration of skin cells, help damaged skin heal faster, and deeply moisturize the skin, prevent water loss, and keep the skin hydrated. BRIEF DESCRIPTION OF THE DRAWINGS

[0045] Figure 1 The following are actual photos of the Centella asiatica compositions with soothing effects prepared in Examples 1, 3, 5, and 9, which are Example 1, Example 3, Example 5, and Example 9 from left to right.

[0046] Figure 2 These are actual photos of the scalp essences prepared in Application Examples 1-4, which are Application Example 1, Application Example 2, Application Example 3, and Application Example 4 from left to right. DETAILED DESCRIPTION

[0047] Examples and Comparative Examples

[0048] A Centella asiatica composition with a soothing effect, the raw materials for its preparation are shown in Table 1 below in terms of weight percentage.

[0049] Table 1

[0050]

[0051]

[0052] The mass fraction of madecassoside in the Centella asiatica extract is 90 wt %, which is purchased from Guangxi Changzhou Natural Pharmaceutical Co., Ltd.

[0053] The Artemisia annua extract was purchased from Quzhou Zhanhong Biotechnology Co., Ltd.

[0054] The white willow bark extract was purchased from Quzhou Zhanhong Biotechnology Co., Ltd.

[0055] The Polygonum multiflorum extract was purchased from Quzhou Zhanhong Biotechnology Co., Ltd.

[0056] The purslane extract was purchased from Quzhou Zhanhong Biotechnology Co., Ltd.

[0057] A method for preparing a Centella asiatica composition having a soothing effect comprises the following steps:

[0058] Mixing the Centella asiatica extract and butylene glycol with stirring at room temperature to obtain a mixture A;

[0059] Add the preservative to hexylene glycol and dissolve it under stirring at 75°C, and mix it with mixture A to obtain mixture B;

[0060] The remaining anti-inflammatory extract and antioxidant extract are added to the mixture B and mixed evenly with deionized water to obtain a Centella asiatica composition with a soothing effect.

[0061] The actual photos of the Centella asiatica compositions with soothing effects prepared in Example 1, Example 3, Example 5, and Example 9 are shown in Figure 1 .

[0062] Application Example 1

[0063] A scalp essence is prepared by comprising, by weight percentage, 10% of a Centella asiatica composition having a soothing effect, 0.1% of disodium EDTA, 0.3% of dipotassium glycyrrhizate, 0.8% of hydrogenated starch hydrolysate, 0.03% of citric acid, 0.72% of phenoxyethanol, 0.08% of ethylhexylglycerin, 0.03% of fragrance, 20% of ethanol, 0.1% of PEG-40 hydrogenated castor oil, and deionized water supplemented to 100%.

[0064] The Centella asiatica composition with soothing effect is the Centella asiatica composition prepared in Example 1.

[0065] A method for preparing a scalp essence comprises the following steps:

[0066] Mix dipotassium glycyrrhizate, disodium EDTA and deionized water evenly;

[0067] Then add phenoxyethanol, ethylhexylglycerin and hydrogenated starch hydrolysate and mix well;

[0068] Finally, citric acid, PEG-40 hydrogenated castor oil, ethanol, essence and the soothing Centella asiatica composition are added and mixed evenly to obtain a scalp essence.

[0069] The actual photo of the prepared scalp essence is shown in Figure 2 Left 1.

[0070] Application Example 2

[0071] A scalp essence and a preparation method thereof. The specific implementation manner is the same as that of Example 1, except that the Centella asiatica composition with a soothing effect is the Centella asiatica composition prepared in Example 3.

[0072] The actual photo of the prepared scalp essence is shown in Figure 2 Left 2.

[0073] Application Example 3

[0074] A scalp essence and a preparation method thereof. The specific implementation manner is the same as that of Example 1, except that the Centella asiatica composition with a soothing effect is the Centella asiatica composition prepared in Example 5.

[0075] The actual photo of the prepared scalp essence is shown in Figure 2 Right 2.

[0076] Application Example 4

[0077] A scalp essence and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that the Centella asiatica composition with a soothing effect is the Centella asiatica composition prepared in Example 9.

[0078] The actual photo of the prepared scalp essence is shown in Figure 2 Right 1.

[0079] Comparative Application Example 1

[0080] A scalp essence and a preparation method thereof. The specific implementation manner is the same as that of Example 1, except that the Centella asiatica composition with a soothing effect is the Centella asiatica composition prepared in Comparative Example 1.

[0081] Application Comparative Example 2

[0082] A scalp essence and a preparation method thereof. The specific implementation manner is the same as that of Example 1, except that the Centella asiatica composition with a soothing effect is the Centella asiatica composition prepared in Comparative Example 2.

[0083] Application Comparative Example 3

[0084] A scalp essence and a preparation method thereof. The specific implementation manner is the same as that of Example 1, except that the Centella asiatica composition with a soothing effect is the Centella asiatica composition prepared in Comparative Example 3.

[0085] Performance Testing

[0086] 1. Hyaluronidase is a specific cleavage enzyme of hyaluronic acid, a participant in allergic reactions, and has a strong correlation with the release of histamine by mast cells. Whether the test sample has a soothing effect can be judged by the hyaluronidase inhibition rate. The higher the hyaluronidase inhibition rate, the stronger the soothing effect of the substance, and vice versa. This test refers to the laboratory method (HMC-WI-029 Hyaluronidase Inhibition Rate). The hyaluronidase inhibition rate test results of the test sample and the negative control are compared. If the inhibition rate of the test sample is higher than that of the negative control and there is a significant difference (P<0.05), the test sample can be considered to have a soothing effect. This test method is an in vitro method and is suitable for evaluating cosmetics that achieve soothing effects by inhibiting hyaluronidase.

[0087] Samples: the Centella asiatica compositions of Examples 1-9 and Comparative Examples 1-3, and the scalp essences of Application Examples 1-4 and Comparative Examples 1-3.

[0088] Positive control group: 3 wt% dipotassium glycyrrhizate aqueous solution.

[0089] Negative control group: pure water.

[0090] Set up sample group, sample background group, solvent group and solvent background group, set up 3 parallel samples for each group, shake well, stand at room temperature for 30 minutes for color development, and measure the absorbance value at a wavelength of 528nm using an ultraviolet spectrophotometer.

[0091] Sample group: 0.1 mL calcium chloride + 0.5 mL hyaluronidase + 0.5 mL sample + 0.5 mL sodium hyaluronate + 0.1 mL sodium hydroxide solution + 0.5 mL acetylacetone + 1 mL Ehrlich reagent + 3 mL anhydrous ethanol;

[0092] Sample background group: 0.1mL calcium chloride + 0.5mL acetate buffer solution + 0.5mL sample + 0.5mL sodium hyaluronate + 0.1mL sodium hydroxide solution + 0.5mL acetylacetone + 1mL Ehrlich reagent + 3mL anhydrous ethanol; solvent group: 0.1mL calcium chloride + 0.5mL hyaluronidase + 0.5mL acetate buffer solution + 0.5mL sodium hyaluronate + 0.1mL sodium hydroxide solution + 0.5mL acetylacetone + 1mL Ehrlich reagent + 3mL anhydrous ethanol; solvent background group: 0.1mL calcium chloride + 0.5mL acetate buffer solution + 0.5mL acetate buffer solution + 0.5mL sodium hyaluronate + 0.1mL sodium hydroxide solution + 0.5mL acetylacetone + 1mL Ehrlich reagent + 3mL anhydrous ethanol.

[0093] The concentration of calcium chloride is 2.5 mol / L, the concentration of sodium hyaluronate is 0.5 mg / mL, and the concentration of sodium hydroxide solution is 5 mol / L.

[0094]

[0095] Where: A is the absorbance of the solvent group; B is the absorbance of the solvent background group; C is the absorbance of the sample group; D is the absorbance of the sample background group.

[0096] The hyaluronidase inhibition rates of the sample group, positive control group, and negative control group were compared using an independent sample t-test. All statistical analyses were two-tailed, with a significance level of α = 0.05. The test results are shown in Table 2.

[0097] Table 2

[0098] name Test results / % P-value Example 1 48.120±2.348 <0.05 Example 2 48.130±2.135 <0.05 Example 3 48.250±2.376 <0.05 Example 4 49.150±2.187 <0.05 Example 5 49.170±2.153 <0.05 Example 6 49.226±2.236 <0.05 Example 7 50.342±1.865 <0.05 Example 8 50.357±1.769 <0.05 Example 9 50.376±1.723 <0.05 Application Example 1 28.236±1.579 <0.05 Application Example 2 28.245±1.535 <0.05 Application Example 3 48.132±2.226 <0.05 Application Example 4 48.126±2.257 <0.05 Comparative Example 1 2.316±0.586 / Comparative Example 2 49.082±2.183 <0.05 Comparative Example 3 2.245±0.783 / Comparative Application Example 1 2.432±0.461 / Application Comparative Example 2 49.136±2.173 <0.05 Application Comparative Example 3 2.185±0.812 / Negative control -0.528±0.457 / Positive control 68.338±1.371 <0.05

[0099] Note: P>0.05 indicates that there is no significant difference between the two groups; P<0.05 indicates that there is a significant difference between the two groups.

[0100] The test results show that the hyaluronidase inhibition rate of the positive control is >50%, and the reaction system is effective. When the sample is a Centella asiatica composition, the hyaluronidase inhibition rate of Examples 1 to 3 is about 48.120%, the hyaluronidase inhibition rate of Examples 4 to 6 is about 49.150%, and the hyaluronidase inhibition rate of Examples 7 to 9 is about 50.342%, which is significantly different from that of the negative control (P<0.05), indicating that the sample has a soothing effect.

[0101] 2. Weather resistance test

[0102] The stability of the Centella asiatica compositions of Examples 1-9 and Comparative Examples 1-3, and the scalp essences of Application Examples 1-4 and Comparative Examples 1-3 were tested.

[0103] Heat resistance: The Centella asiatica composition and scalp essence were placed at 48±2°C for 24 hours, then taken out and returned to room temperature, and the appearance was compared with that before and after the test;

[0104] Cold resistance: The Centella asiatica composition and scalp essence were placed at -18±2°C for 24 hours, then taken out and returned to room temperature, and the performance difference was compared with that before the test;

[0105] High and low temperature cycle test: The Centella asiatica composition and scalp essence were placed at 48±2°C for 1 hour, then quickly taken out and kept at -18±2°C for 1 hour. After 12 cycles, the mixture was taken out and returned to room temperature, and the performance difference was compared with that before the test.

[0106] The test results are shown in Table 3.

[0107] Table 3

[0108]

[0109]

Claims

1. A Centella asiatica composition with soothing effect, characterized in that: The preparation raw materials include, by weight percentage, 12-22% of plant extract, 10-31% of polyol, 0.1-1% of preservative and deionized water supplemented to 100%.

2. The Centella asiatica composition with soothing effect according to claim 1, characterized in that: The plant extracts include anti-inflammatory extracts and antioxidant extracts in a weight ratio of (9.05-17): (3-5).

3. The Centella asiatica composition with soothing effect according to claim 2, characterized in that: The anti-inflammatory extract comprises at least Centella asiatica extract and Artemisia annua extract.

4. The Centella asiatica composition with soothing effect according to claim 2, characterized in that: The anti-inflammatory extracts also include white willow bark extract and purslane extract.

5. The Centella asiatica composition with soothing effect according to claim 2, characterized in that: The antioxidant extract comprises at least one of a Polygonum multiflorum extract, a Platycladus orientalis leaf extract, a Zingiber officinale extract, and a Eclipta prostrata extract.

6. The Centella asiatica composition with soothing effect according to claim 3, characterized in that: The polyol includes at least one of butanediol, hexanediol, propylene glycol or ethylene glycol.

7. A method for preparing the Centella asiatica composition with soothing effect according to claim 6, characterized in that: The following steps are involved: Mixing the Centella asiatica extract and butylene glycol with stirring at room temperature to obtain a mixture A; Add the preservative to hexylene glycol and dissolve it by stirring at 60-90°C, and mix it with mixture A to obtain mixture B; The remaining anti-inflammatory extract and antioxidant extract are added to the mixture B and mixed evenly with deionized water to obtain a Centella asiatica composition with a soothing effect.

8. A scalp essence, characterized in that: The preparation raw materials include the Centella asiatica composition with soothing effect according to any one of claims 1 to 6.

9. The scalp essence according to claim 8, characterized in that: The preparation raw materials include, by weight percentage, 1-10% of the Centella asiatica composition with soothing effect according to any one of claims 1-6, 40-45% of an auxiliary agent, and deionized water to 100%.

10. A method for preparing a scalp essence, characterized in that: The method comprises the following steps: mixing a Centella asiatica composition with a soothing effect with an auxiliary agent and deionized water to obtain a scalp essence.

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