Trace element selenium sustained release tablet and preparation method thereof

Abstract

The invention discloses a selenium element sustained-release tablet and a preparation method thereof, and belongs to the technical field of microelement sustained-release tablet manufacturing. The sustained release tablet is prepared from the following components in percentage by weight: 94.1 to 99.8 percent of calcium sulfate dihydrate, 0.1 to 5.0 percent of nano silicon dioxide and 0.1 to 0.9 percent of sodium selenite. The preparation method of the sustained-release tablet comprises the following steps: uniformly mixing and ball-milling calcium sulfate hemihydrate, nano silicon dioxide and sodium selenite, adding deionized water, stirring, uniformly dispersing and adsorbing selenite ions to the surfaces of calcium sulfate hemihydrate and silicon dioxide particles, injecting slurry into a mold for molding, and drying in an environment with room temperature and relative humidity of 60-90% RH after molding. The sustained release tablet prepared by the invention can slowly and stably release trace element selenium; the preparation process does not need granulation, a pressure forming process, calcination and a low-pressure high-temperature curing process; the prepared sustained release tablet is wide in application, such as a selenium-rich electric cooker, a selenium-rich pressure cooker, a selenium-rich tea cup and the like.

Description

Technical Field

[0001] The invention belongs to the technical field of trace element sustained-release tablet manufacturing, and specifically relates to a trace element selenium sustained-release tablet and a preparation method thereof, and particularly relates to a preparation method of a cast-molded trace element selenium sustained-release tablet. Technical Background

[0002] Selenium is an essential trace element for living organisms, existing in the form of low-molecular-weight compounds (including free selenium) and high-molecular-weight compounds. Its antioxidant effects include: scavenging lipid peroxidation free radical intermediates; decomposing lipid peroxides; repairing molecular damage to sulfur compounds caused by hydrated free radicals (such as HO· and H·); removing or converting hydrated free radicals to stable compounds before they damage living matter; and catalyzing reactions in which sulfhydryl compounds act as protective agents. Selenium and vitamin E exhibit synergistic antioxidant effects. Selenium also possesses anti-cancer and cancer prevention properties.

[0003] Selenium is crucial for human health. A daily intake of 60-400 micrograms is ideal for adults. Long-term daily intake exceeding 400 micrograms can lead to poisoning. Therefore, developing a sustained-release tablet that can slowly and steadily release selenium for use in rice cookers, pressure cookers, teacups, and drinking fountains is crucial. Summary of the Invention

[0004] The technical problem to be solved by the present invention is to provide a sustained-release tablet which releases the trace element selenium slowly and stably and a simple preparation method of the sustained-release tablet.

[0005] The present invention is achieved through the following technical solutions.

[0006] The present invention provides a selenium sustained-release tablet, which is composed of calcium sulfate dihydrate, nano-silicon dioxide and sodium selenite. The proportions of the components by mass are as follows:

[0007] Calcium sulfate dihydrate 94.1-99.8%;

[0008] Nano-silicon dioxide 0.1-5.0%;

[0009] Sodium selenite 0.1-0.9%.

[0010] Furthermore, the particle size of the nano-silicon dioxide is 20-100 nanometers.

[0011] Furthermore, the calcium sulfate dihydrate is 98.1%, nano silicon dioxide is 1%, and sodium selenite is 0.9%.

[0012] The present invention also provides a method for preparing the above-mentioned selenium sustained-release tablets, which specifically comprises the following steps:

[0013] (1) Calcium sulfate hemihydrate, nano-silica and sodium selenite are mixed and ball-milled to form a uniform powder, and then deionized water is added and stirred to form a slurry, so that the selenite ions are uniformly dispersed and adsorbed on the surface of the calcium sulfate hemihydrate and nano-silica; the mass of the deionized water is 20-80% of the mass of the powder;

[0014] (2) The slurry prepared in step (1) is injected into a mold for forming, and after forming, it is placed in an environment of room temperature and relative humidity of 60-90% RH to dry. During this process, calcium sulfate hemihydrate is converted into calcium sulfate dihydrate. After drying, selenium sustained-release tablets can be obtained.

[0015] Furthermore, in step (1), the mass of the deionized water is 40% of the mass of the powder.

[0016] Compared with the prior art, the present invention has the following technical effects:

[0017] 1. The amount of selenium released by the sustained-release tablet prepared by the present invention can be adjusted by controlling the composition of the sustained-release tablet. When the sodium selenite content in the sustained-release tablet is 0.9% and 0.1%, after standing in 300 ml of deionized water for 180 seconds, the selenium content released is 98 μg and 16 μg, respectively.

[0018] 2. The sustained-release tablets prepared by the present invention can stably release selenium. After 20 cycles in static water, the amount of selenium released is 70 μg and 69 μg respectively.

[0019] 3. The preparation process of the present invention does not require granulation, pressure forming, calcination, or low-pressure and high-temperature curing.

[0020] 4. The sustained-release tablets prepared by the present invention have a wide range of uses, such as components of selenium-enriched rice cookers, selenium-enriched pressure cookers, selenium-enriched tea cups, etc. DETAILED DESCRIPTION

[0021] The present invention is described in detail below with reference to specific embodiments, but the present invention is not limited to the following embodiments.

[0022] The preparation process of the sustained-release tablets of the present invention comprises weighing calcium sulfate hemihydrate (calculating the amount of calcium sulfate dihydrate generated by reacting with water), nano-silica, and sodium selenite, placing the mixture in a ball mill jar of a ball mill and subjecting the mixture to high-speed ball milling for uniform mixing; adding deionized water and stirring to obtain a uniform slurry; adding the slurry into a mold, and demolding the mold after the slurry solidifies to obtain a sustained-release tablet; and drying the sustained-release tablet in an environment of room temperature and relatively high relative humidity for 96 hours.

[0023] The selenium-releasing performance of the sustained-release tablets was tested using two methods: first, the sustained-release tablets were added to 300 ml of deionized water, allowed to stand for 180 seconds, the sustained-release tablets were taken out, and the resulting selenium-containing water was subjected to ICP elemental analysis; second, 300 ml of deionized water was added to a 1.8-liter electric cooker (heated at two settings of 300W and 600W, with a pot mouth diameter of 16 cm), a 5.5-cm-high 304 stainless steel steaming rack was placed in the cooker, the sustained-release tablets were placed on the steaming rack, the pot was covered, and heating was performed at 300W. After the water boiled, heating was continued for 30 minutes, and the remaining selenium-rich water was collected for ICP elemental analysis.

[0024] Example 1

[0025] Weigh 82.7 g of calcium sulfate hemihydrate (which reacts with water to form 98.1 g of calcium sulfate dihydrate), 1 g of 20 nm silica, and 900 mg of sodium selenite, place them in the ball mill of a ball mill and mix them evenly at high speed; add 20 g of deionized water, and stir to obtain a uniform slurry; add the slurry to a mold with an inner diameter of 33 mm and a depth of 20 mm, and demold after the slurry solidifies to obtain a sustained-release tablet. Dry the sustained-release tablet in an environment of room temperature and relative humidity of 60% for 96 hours.

[0026] The sustained-release tablet was added to 300 ml of deionized water and allowed to stand for 180 seconds. The sustained-release tablet was removed and the resulting selenium-containing water was subjected to ICP elemental analysis. The total selenium content in the water was 98 μg. The sustained-release tablet was allowed to stand in 300 ml of deionized water for 180 seconds. The selenium-containing water was discarded and a new 300 ml of deionized water was added. The solution was allowed to stand for 180 seconds. After 20 cycles, the selenium-enriched water was subjected to ICP elemental analysis again. The total selenium content in the selenium-enriched water was 96 μg.

[0027] In a 1.8-liter electric cooker (heating at two settings, 300W and 600W, with a 16-cm diameter), add 300 ml of deionized water and place a 5.5-cm-high 304 stainless steel steaming rack. Place the sustained-release tablet on the steaming rack, cover the pot, and heat at 300W. Once the water boils, continue heating for 30 minutes. Collect the remaining selenium-rich water, and perform ICP elemental analysis, which reveals a total selenium content of 94 μg. Place the sustained-release tablet on the steaming rack and steam under the same conditions for 24 hours. During the steaming process, continuously add boiling deionized water to the pot, maintaining the water level roughly constant. Discard the remaining selenium-rich water. Then, steam the sustained-release tablet with 300 ml of deionized water for 30 minutes under the same conditions. Collect the remaining selenium-rich water, and perform ICP elemental analysis, which reveals a total selenium content of 92 μg.

[0028] Example 2

[0029] Weigh 82.1 g of calcium sulfate hemihydrate (which reacts with water to form 97.4 g of calcium sulfate dihydrate), 2.0 g of silica with a particle size of 40 nm, and 600 mg of sodium selenite, place them in the ball mill of a ball mill and mix them at high speed; add 40 g of deionized water, and stir to obtain a uniform slurry; add the slurry to a mold with an inner diameter of 33 mm and a depth of 20 mm, and demold after the slurry solidifies to obtain a sustained-release tablet. Dry the sustained-release tablet in an environment of room temperature and a relative humidity of 80% for 120 hours.

[0030] The sustained-release tablet was added to 300 ml of deionized water and allowed to stand for 180 seconds. The sustained-release tablet was removed and the resulting selenium-containing water was subjected to ICP elemental analysis. The total selenium content in the water was 70 μg. The sustained-release tablet was allowed to stand for 180 seconds in 300 ml of deionized water. The selenium-containing water was discarded and a new 300 ml of deionized water was added. The water was allowed to stand for 180 seconds. After 20 cycles, the selenium-enriched water was subjected to ICP elemental analysis again. The total selenium content in the selenium-enriched water was 69 μg.

[0031] In a 1.8-liter electric cooker (heated at two settings, 300W and 600W, with a 16-cm diameter), add 300 ml of deionized water and place a 5.5-cm-high 304 stainless steel steaming rack. Place the sustained-release tablet on the steaming rack, cover the pot, and heat at 300W. Once the water boils, continue heating for 30 minutes. Collect the remaining selenium-rich water, and perform ICP elemental analysis, which reveals a total selenium content of 72 μg. Place the sustained-release tablet on the steaming rack and steam under the same conditions for 24 hours. During the steaming process, continuously add boiling deionized water to the pot, maintaining the water level at a constant level. Discard the remaining selenium-rich water. Then, steam the sustained-release tablet with 300 ml of deionized water for 30 minutes under the same conditions. Collect the remaining selenium-rich water, and perform ICP elemental analysis, which reveals a total selenium content of 73 μg.

[0032] Example 3

[0033] Weigh 79.3 g of calcium sulfate hemihydrate (which reacts with water to form 94.1 g of calcium sulfate dihydrate), 5.0 g of 60 nm silica, and 900 mg of sodium selenite, place them in the ball mill of a ball mill and mix them evenly at high speed. Add 60 g of deionized water and stir to obtain a uniform slurry. Add the slurry to a mold with an inner diameter of 33 mm and a depth of 20 mm. After the slurry solidifies, demold the mold to obtain a sustained-release tablet. Dry the sustained-release tablet in an environment of room temperature and a relative humidity of 90% for 144 hours.

[0034] The sustained-release tablet was added to 300 ml of deionized water and allowed to stand for 180 seconds. The sustained-release tablet was removed and the resulting selenium-containing water was subjected to ICP elemental analysis. The total selenium content in the water was 75 μg. The sustained-release tablet was allowed to stand for 180 seconds in 300 ml of deionized water. The selenium-containing water was discarded and a new 300 ml of deionized water was added. The solution was allowed to stand for 180 seconds. After 20 cycles, the selenium-enriched water was subjected to ICP elemental analysis again. The total selenium content in the selenium-enriched water was 77 μg.

[0035] In a 1.8-liter electric cooker (heated at two settings, 300W and 600W, with a 16-cm diameter), add 300 ml of deionized water and place a 5.5-cm-high 304 stainless steel steaming rack. Place the sustained-release tablet on the steaming rack, cover the pot, and heat at 300W. Once the water boils, continue heating for 30 minutes. Collect the remaining selenium-rich water, and perform ICP elemental analysis, which reveals a total selenium content of 73 μg. The sustained-release tablet was then placed on the steaming rack and steamed under the same conditions for 24 hours. During the steaming process, boiled deionized water was continuously added to the pot, maintaining the water level at a constant level. The resulting selenium-rich water was discarded. Another 300 ml of deionized water was then added to the sustained-release tablet under the same conditions for 30 minutes. The remaining selenium-rich water was collected, and ICP elemental analysis revealed a total selenium content of 71 μg.

[0036] Example 4

[0037] Weigh 82.5 g of calcium sulfate hemihydrate (which reacts with water to form 97.9 g of calcium sulfate dihydrate), 2.0 g of 100 nm silica, and 100 mg of sodium selenite, place them in the ball mill of a ball mill and mix them evenly at high speed. Add 80 g of deionized water and stir to obtain a uniform slurry. Add the slurry to a mold with an inner diameter of 33 mm and a depth of 20 mm. After the slurry solidifies, demold the mold to obtain a sustained-release tablet. Dry the sustained-release tablet at room temperature and a relative humidity of 80% for 100 hours.

[0038] The sustained-release tablet was added to 300 ml of deionized water and allowed to stand for 180 seconds. The sustained-release tablet was removed and the resulting selenium-containing water was subjected to ICP elemental analysis. The total selenium content in the water was 16 μg. The sustained-release tablet was allowed to stand for 180 seconds in 300 ml of deionized water. The selenium-containing water was discarded and a new 300 ml of deionized water was added. The solution was allowed to stand for 180 seconds. After 20 cycles, the selenium-enriched water was subjected to ICP elemental analysis again. The total selenium content in the selenium-enriched water was 15 μg.

[0039] In a 1.8-liter electric cooker (heating at two settings, 300W and 600W, with a 16-cm diameter), add 300 ml of deionized water and place a 5.5-cm-high 304 stainless steel steaming rack. Place the sustained-release tablet on the steaming rack, cover the pot, and heat at 300W. Once the water boils, continue heating for 30 minutes. Collect the remaining selenium-rich water, and perform ICP elemental analysis, which reveals a total selenium content of 18 μg. Place the sustained-release tablet on the steaming rack and steam under the same conditions for 24 hours. During the steaming process, continuously add boiling deionized water to the pot, maintaining the water level roughly constant. Discard the remaining selenium-rich water. Then, steam the sustained-release tablet with 300 ml of deionized water for 30 minutes under the same conditions. Collect the remaining selenium-rich water, and perform ICP elemental analysis, which reveals a total selenium content of 19 μg.

[0040] Example 5

[0041] Weigh 83.1 g of calcium sulfate hemihydrate (which reacts with water to form 98.6 g of calcium sulfate dihydrate), 1.0 g of 60 nm silica, and 400 mg of sodium selenite, place them in the ball mill of a ball mill and mix them evenly at high speed. Add 70 g of deionized water and stir to obtain a uniform slurry. Add the slurry to a mold with an inner diameter of 33 mm and a depth of 20 mm. After the slurry solidifies, demold the mold to obtain a sustained-release tablet. Dry the sustained-release tablet in an environment of room temperature and a relative humidity of 85% RH for 120 hours.

[0042] The sustained-release tablet was added to 300 ml of deionized water and allowed to stand for 180 seconds. The sustained-release tablet was removed and the selenium-containing water obtained after 96 hours was subjected to ICP elemental analysis. The total selenium content in the water was 48 μg. The sustained-release tablet was allowed to stand for 180 seconds in 300 ml of deionized water. The selenium-containing water was discarded and a new 300 ml of deionized water was added. The water was allowed to stand for 180 seconds. After 20 cycles, the selenium-enriched water was subjected to ICP elemental analysis again. The total selenium content in the selenium-enriched water was 49 μg.

[0043] In a 1.8-liter electric cooker (heated at two settings, 300W and 600W, with a 16-cm diameter), add 300 ml of deionized water and place a 5.5-cm-high 304 stainless steel steaming rack. Place the sustained-release tablet on the steaming rack, cover the pot, and heat at 300W. Once the water boils, continue heating for 30 minutes. Collect the remaining selenium-rich water, and perform ICP elemental analysis, which reveals a total selenium content of 43 μg. The sustained-release tablet was placed on the steaming rack and steamed under the same conditions for 24 hours. During the steaming process, boiled deionized water was continuously added to the pot, maintaining the water level essentially constant. The resulting selenium-rich water was discarded. Another 300 ml of deionized water was then added to the sustained-release tablet under the same conditions for 30 minutes. The remaining selenium-rich water was collected, and ICP elemental analysis revealed a total selenium content of 41 μg.

[0044] Example 6

[0045] Weigh 84.1 g of calcium sulfate hemihydrate (which reacts with water to form 99.8 g of calcium sulfate dihydrate), 0.1 g of 100 nm silica, and 100 mg of sodium selenite, place them in the ball mill of a ball mill and mix them evenly at high speed. Add 80 g of deionized water and stir to obtain a uniform slurry. Add the slurry to a mold with an inner diameter of 33 mm and a depth of 20 mm. After the slurry solidifies, demold the mold to obtain a sustained-release tablet. Dry the sustained-release tablet in an environment of room temperature and a relative humidity of 80% for 96 hours.

[0046] The sustained-release tablet was added to 300 ml of deionized water and allowed to stand for 180 seconds. The sustained-release tablet was removed and the resulting selenium-containing water was subjected to ICP elemental analysis. The total selenium content in the water was 22 μg. The sustained-release tablet was allowed to stand in 300 ml of deionized water for 180 seconds. The selenium-containing water was discarded and a new 300 ml of deionized water was added. The water was allowed to stand for 180 seconds. After 20 cycles, the selenium-enriched water was subjected to ICP elemental analysis again. The total selenium content in the selenium-enriched water was 25 μg.

[0047] In a 1.8-liter electric cooker (heating at two settings, 300W and 600W, with a 16-cm diameter), add 300 ml of deionized water and place a 5.5-cm-high 304 stainless steel steaming rack. Place the sustained-release tablet on the steaming rack, cover the pot, and heat at 300W. Once the water boils, continue heating for 30 minutes. Collect the remaining selenium-rich water, and perform ICP elemental analysis, which reveals a total selenium content of 19 μg. Place the sustained-release tablet on the steaming rack and steam under the same conditions for 24 hours. During the steaming process, continuously add boiling deionized water to the pot, maintaining the water level roughly constant. Discard the remaining selenium-rich water. Then, steam the sustained-release tablet with 300 ml of deionized water for 30 minutes under the same conditions. Collect the remaining selenium-rich water, and perform ICP elemental analysis, which reveals a total selenium content of 18 μg.

Claims

1. A selenium sustained-release tablet, characterized in that: The sustained-release tablets are composed of calcium sulfate dihydrate, nano-silicon dioxide and sodium selenite. The proportions of the components by mass are as follows: Calcium sulfate dihydrate 94.1-99.8%; Nano-silicon dioxide 0.1-5.0%; Sodium selenite 0.1-0.9%.

2. The selenium sustained-release tablet according to claim 1, characterized in that The particle size of the nano-silicon dioxide is 20-100 nanometers.

3. The selenium sustained-release tablet according to claim 1, characterized in that The calcium sulfate dihydrate is 98.1%, the nano silicon dioxide is 1%, and the sodium selenite is 0.9%.

4. The method for preparing the selenium sustained-release tablet according to claim 1, wherein The following steps are included: (1) Calcium sulfate hemihydrate, nano-silica and sodium selenite are mixed and ball-milled to form a powder, and then deionized water is added and stirred to form a slurry; the mass of the deionized water is 20-80% of the mass of the powder; (2) The slurry prepared in step (1) is injected into a mold for molding, and then placed in an environment with room temperature and relative humidity of 60-90% RH for drying.

5. The method for preparing the selenium sustained-release tablet according to claim 4, wherein: In step (1), the mass of the deionized water is 40% of the mass of the powder.