Traditional Chinese medicine composition containing medicinal powder and extracting solution for external application, internal regulation, dampness elimination, cold expelling and bone health care

Abstract

The invention discloses a traditional Chinese medicine external application and internal regulation bone health-care composition containing medicine powder and an extracting solution, and belongs to the technical field of traditional Chinese medicines. Aiming at the problems of slow curative effect, low transdermal absorption rate and the like of the traditional medicine for treating bone diseases, the composition is prepared from 27 traditional Chinese medicines through compatibility, plant extract health-care essence powder is prepared through nanoscale crushing and extraction processes, the particle size is less than or equal to 100nm, and the drug loading capacity is 60 times of that of the conventional amount; through a nano drug-loaded transdermal enhancer and a targeted drug delivery technology, rapid drug permeation and precise focus repair are realized, pain is significantly relieved within 3 minutes, the efficacy lasts for 36 hours, and the drug is safe and noninvasive. The composition is suitable for various bone diseases such as hyperostosis, old fracture, femoral head necrosis and the like. The invention also provides a preparation method and an external application conditioning method of the composition, and indicates that the improvement reaction possibly occurring in use is a normal phenomenon. The patent protection range of the invention covers the compatibility proportion of 27 traditional Chinese medicines, a preparation process, an essence powder extraction method and an external application conditioning method.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and specifically to an external application and internal conditioning composition prepared by combining 27 kinds of traditional Chinese medicines, which is used for removing dampness and cold, relaxing muscles and activating blood circulation, strengthening bones and treating related arthritis. Background Art

[0002] Traditional Chinese medicine has long relied on single means such as oral decoctions or external plasters to treat bone diseases such as bone hyperplasia, old fractures, and femoral head necrosis. Although oral medications can act on the whole body through blood circulation, they have problems such as significant first-pass effect and heavy metabolic burden on the liver and kidneys, resulting in a concentration of less than 30% of the active ingredients reaching the lesion site, especially limited penetration into deep muscle and bone lesions; and although traditional plasters can be administered topically, they are limited by the particle size of the crushed medicinal materials (usually >100μm) and the transdermal performance of the matrix, resulting in a slow drug release rate (usually more than 24 hours), and it is difficult to break through the skin's stratum corneum barrier, with an actual absorption rate of less than 15%. In addition, existing technologies mostly use single drugs or simple compound prescriptions, and lack in-depth research on the synergistic effects of multiple targets such as "dispelling wind and cold, promoting blood circulation and removing blood stasis, and tonifying the kidneys and strengthening bones", resulting in a treatment cycle of several months or even years, and are prone to skin allergies, drug resistance, and other problems due to drug residues.

[0003] In recent years, the integration of nanotechnology and transdermal drug delivery systems has provided a new direction for the modernization of traditional Chinese medicine. Studies have shown that reducing the drug particle size to the nanoscale (<100nm) can significantly increase the specific surface area, increasing the contact efficiency of the drug with the biomembrane by more than 10 times; at the same time, by encapsulating the drug through carriers such as liposomes and microemulsions, a hydrophilic-lipophilic dual-channel transdermal pathway can be constructed, breaking through the limitation of traditional plasters that rely solely on passive diffusion. However, existing nano-TCM technology still has the following defects: (1) poor biocompatibility of carrier materials, which can easily induce local inflammatory reactions; (2) low drug loading (usually <20%), which makes it difficult to meet the long-term treatment needs of chronic diseases; (3) lack of precise regulation of the synergistic effects of multiple components of traditional Chinese medicine compound, resulting in unstable efficacy. Summary of the Invention

[0004] The present invention aims to provide a Chinese medicine composition containing medicine powder and extract for external application, internal regulation, dehumidification and cold removal, and bone health care. Through nano-drug transdermal promoter and targeted drug delivery technology, combined with the synergistic effect of 27 Chinese medicines, the drug release rate and human absorption efficiency are significantly improved, achieving rapid analgesia, long-lasting sustained release and precise repair of lesions.

[0005] To achieve the above object, the present invention is implemented through the following technical solutions:

[0006] The Chinese medicine composition for external application, internal regulation, expelling dampness and removing cold, and bone health care, comprising medicine powder and extract, is prepared by combining the following raw materials within the following weight ranges:

[0007] 290-350g of Panax notoginseng, 1500-1700g of ginger, 280-330g of Millettia reticulata, 190-240g of Salvia miltiorrhiza, 260-310g of Clematis chinensis, 290-350g of Angelica sinensis, 380-430g of Radix schizonepetae, 390-430g of Herba Lycopodii, 430-510g of Rhizoma Cynanchi, 500-620g of cinnamon twig, 270-350g of Pinellia ternata, 380-420g of Pueraria root, 530-620g of Licorice root, 300-300g of Scutellaria baicalensis. 50-450 grams, Eucommia ulmoides 520-610 grams, Cynomorium songaricum 260-320 grams, Earthworm 600-700 grams, Gastrodia elata 420-450 grams, Myrrh 210-280 grams, Drynaria fortunei 300-400 grams, Borneolum 230-310 grams, Alum 230-350 grams, Ganoderma lucidum 450-550 grams, Sambucus 670-760 grams, Mint 500-600 grams, Yellow rice wine 800-950 grams, Rice vinegar 800-950 grams;

[0008] The composition is prepared into plant-extracted health-care essence powder through nano-scale pulverization and low-temperature extraction processes, with a particle size of ≤100 nm, a drug loading amount that is 60 times the conventional amount, and a nano-drug loading transdermal enhancer is added.

[0009] Furthermore, the nano drug-carrying transdermal enhancer is at least one of liposomes, nano-microemulsions or chitosan derivatives, and its mass accounts for 1% to 5% of the total amount of the composition.

[0010] Furthermore, the preparation method of the plant extract health essence powder comprises the following steps:

[0011] (1) 27 Chinese medicinal herbs were weighed in proportion and ultrafinely ground into nano-sized particles at low temperature;

[0012] (2) adding yellow rice wine and rice vinegar for low-temperature extraction, filtering and concentrating to obtain essence powder;

[0013] (3) Mix the nano-TCM powder and the essence powder, add the nano-drug-carrying transdermal enhancer, stir evenly and seal the mixture.

[0014] Furthermore, a Chinese medicine composition containing powder and extract for external application, internal regulation, expelling dampness and removing cold for bone health care is used in the preparation of drugs for treating bone diseases, including bone hyperplasia, old fractures, femoral head necrosis, muscle and bone pain, traumatic injuries and numbness of the limbs.

[0015] Furthermore, a method for external application of a Chinese medicine composition containing a powder and an extract for internal regulation of dampness, cold and bone health care, comprising the following steps:

[0016] (1) Prepare the medicinal solution: Pour the essence powder into a clean container, add the permeate and appropriate amount of hot water, and stir evenly until it becomes a paste. The permeate is a mixture of yellow wine and rice vinegar;

[0017] (2) Apply and wrap: Apply the liquid medicine evenly to the painful area, cover with plastic wrap, and use for 30 minutes for the first time and 40 to 60 minutes each time thereafter;

[0018] (3) Cleaning the residue: After removing the plastic wrap, use a card to scrape off the remaining liquid, wipe it clean with a dry towel, and do not use water to clean it;

[0019] (4) Usage cycle: once a day for the first three days, then twice a week, and adjust the course of treatment according to physical condition and condition;

[0020] (5) Dietary taboos: Do not eat spicy food, irritating food, seafood and alcohol during the conditioning period.

[0021] Furthermore, during the conditioning process, there may be improvement reactions such as local fever or slight tingling, which are normal phenomena of drug action and there is no need to interrupt treatment.

[0022] Furthermore, the mass ratio of ginger to mint in the raw materials is (1500-1700):(500-600), and the mass ratio of cassia twig to licorice is (500-620):(530-620), so as to optimize transdermal absorption and anti-inflammatory and analgesic effects.

[0023] Furthermore, a preparation device for a Chinese medicine external application, internal regulation, dehumidification, cold removal and bone health care composition based on medicinal powder and extract liquid includes a low-temperature ultrafine grinder, a nano-scale sieving instrument, a low-temperature extraction tank and a mixing agitator. The device is used to achieve nano-processing of raw materials and low-temperature concentration of essence powder.

[0024] Furthermore, the pulverizing temperature of the low-temperature ultrafine pulverizer is controlled at -20°C to 10°C, and the aperture of the sieve is 50 to 100 nm.

[0025] Beneficial effects of the present invention:

[0026] Rapid pain relief: Nano-drug-loaded transdermal enhancers allow the drug to penetrate into the lesion within 3 minutes, significantly reducing pain.

[0027] Targeted repair: Through transdermal absorption and targeted drug delivery technology, it acts directly on the affected area, softens and ablates the diseased tissue, and repairs deformed bones.

[0028] Long-lasting sustained release: The effect lasts for 36 hours, and the efficacy is significantly better than traditional topical medications.

[0029] Safe and non-invasive: Combining external application with internal regulation to avoid the side effects of oral medications on the liver and kidneys. DETAILED DESCRIPTION

[0030] The scheme of the present invention is described in more detail and completely below. Specific embodiment:

[0032] 1. Composition formula and raw material selection

[0033] Core API Ratio (Weight Range)

[0034] 290-350g of Panax notoginseng, 1500-1700g of ginger, 280-330g of Millettia reticulata, 190-240g of Salvia miltiorrhiza, 260-310g of Clematis chinensis, 290-350g of Radix Angelicae Sinensis, 380-430g of Radix Achyranthis Bidentatae, 390-430g of Herba Lycopodii, 430-510g of Rhizoma Cynanchi, 500-620g of Cassia twig, 270-350g of Pinellia ternata, 380-420g of Pueraria root, 530-620g of Licorice root, 300-300g of Radix Scutellariae. 50-450g, Eucommia ulmoides 520-610g, Cynomorium songaricum 260-320g, Earthworm 600-700g, Gastrodia elata 420-450g, Myrrh 210-280g, Drynaria fortunei 300-400g, Borneolum 230-310g, Alum 230-350g, Ganoderma lucidum 450-550g, Comfrey 670-760g, Mint 500-600g, Yellow rice wine 800-950g, Rice vinegar 800-950g.

[0035] Among them, the medicinal properties of the above 27 raw materials are analyzed as follows:

[0036] Blood-activating and blood-stasis-removing drugs (9 types) Panax notoginseng

[0038] Medicinal properties: warm in nature, sweet and slightly bitter in taste, enters the liver and stomach meridians;

[0039] Efficacy: dissipates blood stasis and stops bleeding, reduces swelling and relieves pain, promotes callus formation, and inhibits platelet aggregation;

[0040] Application: In the early stage of fracture, blood stasis, swelling and pain can be treated with Drynaria fortunei to enhance the effect of promoting blood circulation and setting bones.

[0041] Salvia miltiorrhiza

[0042] Medicinal properties: slightly cold, bitter, enters the heart and liver meridians;

[0043] Efficacy: Activate blood circulation, remove blood stasis, relieve menstruation and pain, improve microcirculation, and reduce blood viscosity;

[0044] Application: It can be used to treat blood stasis in chronic bone disease and can work together with Angelica sinensis to replenish blood and activate blood circulation.

[0045] Millettia reticulata

[0046] Medicinal properties: warm in nature, sweet and bitter in taste, enters the liver and kidney meridians;

[0047] Efficacy: Promotes blood circulation and replenishes blood, relaxes tendons and activates collaterals, dilates blood vessels, and increases blood supply to bone tissue;

[0048] Application: Rheumatic pain accompanied by blood deficiency, combined with Rhizoma Cynanchum to enhance the effect of clearing the meridians.

[0049] Niu Ma Teng

[0050] Medicinal properties: warm in nature, bitter in taste, enters the liver and stomach meridians;

[0051] Efficacy: Promotes blood circulation, dredges meridians, dispels wind and relieves pain, contains luteolin for anti-inflammatory and analgesic effects;

[0052] Application: It can be used to relax the fascia by synergizing with Stretching Muscle Grass to relieve muscle spasms after trauma.

[0053] Angelica

[0054] Medicinal properties: warm in nature, sweet and spicy in taste, enters the liver, heart and spleen meridians;

[0055] Efficacy: replenishing blood and activating blood circulation, regulating menstruation and relieving pain, promoting red blood cell production, and improving anemic bone pain;

[0056] Application: For osteoporosis of blood deficiency type, it can be used with Astragalus membranaceus (although not included in this prescription, it is often used in combination) to replenish Qi and generate blood.

[0057] Herba Lycopodii

[0058] Medicinal properties: sweet, neutral, spicy, enters the liver and kidney meridians;

[0059] Efficacy: dispel wind and dampness, disperse blood stasis and reduce swelling, penetrate the periosteum and act directly on the lesion;

[0060] Application: Deep bone spur pain, combined with Clematis chinensis to enhance the bone penetrating effect.

[0061] Stretching grass

[0062] Medicinal properties: warm in nature, enters the liver, spleen and kidney meridians;

[0063] Efficacy: Relaxes muscles and tendons, dispels wind and cold, relieves muscle spasms and joint stiffness;

[0064] Application: Joint contracture after old fracture, synergistically used with Radix Polygoni Multiflori to loosen adhesions.

[0065] Myrrh

[0066] Medicinal properties: neutral in nature, pungent and bitter in taste, enters the heart, liver and spleen meridians;

[0067] Efficacy: Promotes blood circulation and relieves pain, reduces swelling and promotes tissue regeneration, inhibits prostaglandin synthesis, and reduces inflammatory reactions;

[0068] Application: For swollen and painful bones and joints, it can be used together with frankincense (although not included in this prescription, it is often used in combination) to promote blood circulation and relieve pain.

[0069] comfrey

[0070] Medicinal properties: Cool in nature, sweet and bitter in taste, enters the liver meridian;

[0071] Efficacy: Activates blood circulation and removes blood stasis, strengthens bones and tendons, and contains flavonoids to promote callus growth;

[0072] Application: Repair of fractures in the middle and late stages, combined with Drynaria fortunei and Earthworm to form a core bone-setting medicine group.

[0073] Wind-dispelling and cold-relieving drugs (7 types)

[0074] ginger

[0075] Medicinal properties: slightly warm in nature, pungent in taste, enters the lung, spleen, and stomach meridians;

[0076] Efficacy: dispels cold and warms the middle part of the body to stop vomiting, contains gingerol to promote local blood circulation;

[0077] Application: When applied externally, it can dispel cold pathogens through fever, and can be used with cinnamon twigs to enhance the effect of warming the meridians.

[0078] Clematis

[0079] Medicinal properties: warm in nature, pungent and salty in taste, enters the bladder meridian;

[0080] Efficacy: dispel rheumatism, dredge meridians and relieve pain, soften bone spurs, and relieve smooth muscle spasms;

[0081] Application: It can treat pain caused by bone hyperplasia in the cervical and lumbar vertebrae and can be used together with Radix Poriae to penetrate the periosteum.

[0082] cinnamon twig

[0083] Medicinal properties: warm in nature, pungent and sweet in taste, enters the heart, lung and bladder meridians;

[0084] Efficacy: induces sweating and relieves muscle tension, warms and dredges the meridians, dilates peripheral blood vessels, and reduces vascular resistance;

[0085] Application: Cold pain in limbs caused by wind-cold-dampness, combined with ginger to enhance the cold-dispelling effect.

[0086] Pinellia

[0087] Medicinal properties: warm in nature, pungent in taste, toxic, enters the spleen, stomach, and lung meridians;

[0088] Efficacy: Drying dampness and resolving phlegm, relieving adverse reactions and stopping vomiting, external application to reduce swelling and relieve pain, and regulate local metabolism;

[0089] Application: For bone and joint swelling of cold and dampness type, it can be used together with Scutellaria baicalensis to harmonize the cold and heat tendencies.

[0090] Mint

[0091] Medicinal properties: Cool in nature, pungent in taste, enters the lung and liver meridians;

[0092] Efficacy: Dispels wind-heat, clears the head, contains menthol to promote drug transdermal absorption;

[0093] Application: It relieves pain through cooling sensation when applied externally, and balances the warm and cool properties when used with ginger.

[0094] Pueraria root

[0095] Medicinal properties: Cool in nature, sweet and spicy in taste, enters the spleen, stomach and lung meridians;

[0096] Efficacy: Relieves muscle pain, reduces fever, promotes the production of body fluids and quenches thirst, and relieves skin redness and swelling caused by external application irritation;

[0097] Application: Balance the dryness and heat of warm herbs in prescriptions and improve patients' skin tolerance.

[0098] Gastrodia elata

[0099] Medicinal properties: neutral in nature, sweet in taste, enters the liver meridian;

[0100] Efficacy: calms wind and stops spasms, calms liver yang, dispels wind and dredges meridians. Contains ingredients such as gastrodin, which can calm, resist convulsions, and improve cerebral blood flow.

[0101] Application: It is used to treat dizziness and headache caused by internal liver wind (such as hypertension, migraine), limb numbness, and rheumatic pain. It can be used in combination with Uncaria rhynchophylla, Ligusticum chuanxiong, etc. to enhance the effect of calming the liver and relieving wind or dispelling wind and relieving pain.

[0102] Kidney-tonifying and bone-strengthening products (4 types)

[0103] Eucommia ulmoides

[0104] Medicinal properties: warm in nature, sweet in taste, enters the liver and kidney meridians;

[0105] Efficacy: Nourishes the liver and kidneys, strengthens tendons and bones, and contains Eucommia gum to enhance ligament elasticity;

[0106] Application: Kidney deficiency type osteoporosis with soreness of waist and knees, combined with Cynomorium songaricum to enhance the kidney-tonifying effect.

[0107] Cynomorium songaricum

[0108] Medicinal properties: warm in nature, sweet in taste, enters the liver, kidney and large intestine meridians;

[0109] Efficacy: replenishes kidney yang, improves essence and blood, contains estrogen-like substances to regulate bone metabolism;

[0110] Application: Kidney Yang deficiency type bone disease, synergistically improves bone microstructure with Eucommia ulmoides.

[0111] Drynaria fortunei

[0112] Medicinal properties: warm in nature, bitter in taste, enters the liver and kidney meridians;

[0113] Efficacy: nourishes the kidney and strengthens bones, heals injuries and relieves pain, promotes osteoblast activity, and inhibits osteoclast differentiation;

[0114] Application: During the fracture repair period, it can be used together with earthworms to form a "bone-setting medicine".

[0115] Earth Element (earth beetle)

[0116] Medicinal properties: cold in nature, salty in taste, slightly toxic, enters the liver meridian;

[0117] Efficacy: It can break blood and remove blood stasis, strengthen tendons and bones, and contains amino acids and collagen to promote bone healing;

[0118] Application: For fractures caused by trauma, it can be used together with Drynaria fortunei to accelerate callus formation.

[0119] Heat-clearing and detoxifying products (3 types)

[0120] Scutellaria baicalensis

[0121] Medicinal properties: cold in nature, bitter in taste, enters the lung, gallbladder, spleen, stomach, large intestine, and small intestine meridians;

[0122] Efficacy: Clears away heat and dampness, purges fire and detoxifies, inhibits the release of inflammatory factors, and reduces tissue edema;

[0123] Application: Balances the dryness and heat of warm herbs in prescriptions, and treats swelling and pain in bones and joints due to damp-heat.

[0124] Alum

[0125] Medicinal properties: cold in nature, sour and astringent in taste, enters the lung, spleen, liver and large intestine meridians;

[0126] Efficacy: External use for detoxification and killing insects, drying dampness and relieving itching, tightening wounds and preventing infection;

[0127] Application: Skin ulcers after external application for bone diseases, combined with borneol to enhance the antibacterial effect.

[0128] borneol

[0129] Medicinal properties: slightly cold in nature, pungent and bitter in taste, enters the heart, spleen and lung meridians;

[0130] Efficacy: refreshing, clearing away heat and relieving pain; containing borneol to promote drug transdermal absorption;

[0131] Application: When applied externally, it acts as a transdermal enhancer, synergizing with mint to enhance the cooling and analgesic effects.

[0132] Blending medicinal properties (2 types)

[0133] Licorice

[0134] Medicinal properties: neutral in nature, sweet in taste, enters the heart, lung, spleen, and stomach meridians;

[0135] Efficacy: tonifies the spleen and replenishes Qi, clears away heat and detoxifies, relieves pain, and harmonizes various medicines;

[0136] Application: Alleviate the toxicity of some medicinal materials in the prescription (such as Pinellia ternata) and reconcile the conflict between cold and hot medicinal properties.

[0137] Ganoderma lucidum

[0138] Medicinal properties: neutral in nature, sweet in taste, enters the heart, lung, liver, and kidney meridians;

[0139] Efficacy: replenishes qi and calms the mind, relieves cough and asthma, enhances immunity, and regulates the bone metabolism microenvironment;

[0140] Application: Improves the patient's overall physical condition and assists in bone repair, with similar effects to astragalus (although not included in this prescription).

[0141] Transdermal enhancement (2 types)

[0142] Yellow rice wine

[0143] Medicinal properties: warm in nature, pungent and sweet in taste, enters the heart, liver, lung and stomach meridians;

[0144] Efficacy: Activates blood circulation, dredges meridians, dispels cold and relieves pain; contains ethanol to dissolve fat-soluble components and promote drug penetration;

[0145] Application: As a solvent to enhance the transdermal efficiency of herbs such as Radix Scutellariae and Radix Clematis.

[0146] rice vinegar

[0147] Medicinal properties: warm in nature, sour and bitter in taste, enters the liver and stomach meridians;

[0148] Efficacy: dispersing blood stasis and stopping bleeding, detoxifying and killing insects, containing organic acids to soften the stratum corneum and improve drug bioavailability;

[0149] Application: Used in combination with rice wine as a permeate to create an acidic environment to promote drug release.

[0150] Key ratio optimization:

[0151] The mass ratio of ginger to mint is (1500-1700):(500-600), which enhances transdermal heat dissipation and anti-inflammatory effects;

[0152] The mass ratio of cinnamon twig to liquorice is (500-620):(530-620), which balances the effects of warming the meridians and unblocking the collaterals with harmonizing the medicinal properties.

[0153] Nano drug-loaded transdermal enhancers

[0154] At least one of liposomes, nano-microemulsions or chitosan derivatives is selected, with a mass proportion of 1% to 5% of the total amount of the composition, to improve the transdermal absorption rate of the drug.

[0155] 2. Preparation process implementation steps

[0156] Low temperature ultrafine grinding

[0157] Equipment: Low-temperature ultrafine pulverizer (pulverization temperature -20℃~10℃);

[0158] Operation: Weigh 27 kinds of Chinese medicine according to the proportion and put them into the grinder, grind them into nano-scale particles (particle size ≤ 100nm), and filter them through a nano-scale sieving instrument (pore size 50-100nm) to ensure the uniformity of particle size.

[0159] Low temperature extraction

[0160] Equipment: Low temperature extraction tank;

[0161] Operation: Mix nano-scale Chinese medicine powder with rice wine and rice vinegar in proportion, extract at low temperature of 40℃~50℃ for 2~3 hours, filter and concentrate to obtain plant extract health essence powder, with a drug loading capacity 60 times that of the conventional amount.

[0162] Mixing and drug loading promoter addition

[0163] Equipment: Mixing agitator;

[0164] Operation: Mix nano-TCM powder and essence powder in a ratio of 1:0.8-1.2, add nano-drug-carrying transdermal enhancer (such as liposomes), stir until uniform and seal for packaging.

[0165] 3. Application method implementation steps

[0166] External application conditioning process

[0167] Prepare the liquid: Pour 50g of the essence powder into a non-metallic container, add 30ml of the permeation solution (a mixture of yellow rice wine and rice vinegar in a ratio of 1:1) and 50ml of hot water, and stir until it becomes a paste.

[0168] Apply and wrap: Apply the liquid medicine evenly to the painful area (such as knee joint, lumbar spine), cover with plastic wrap, and use it for 30 minutes for the first time and 40 to 60 minutes each time thereafter;

[0169] Cleaning residues: After removing the plastic wrap, use a plastic card to scrape off the remaining liquid, wipe it clean with a dry towel, and do not use water to clean it;

[0170] Usage cycle: once a day for the first 3 days, then twice a week. The course of treatment is adjusted according to the physical condition and condition (usually 4 to 6 weeks as a course of treatment).

[0171] Dietary taboos and precautions

[0172] During the conditioning period, do not eat spicy food, irritating foods (such as mutton, seafood), or alcohol;

[0173] Local fever or slight tingling may occur, which is an improvement reaction and does not require interruption of treatment;

[0174] Pregnant women and people with damaged skin are prohibited from using this product.

[0175] 4. Preparation device parameters and implementation conditions

[0176] Low temperature ultrafine grinder

[0177] Crushing temperature: -20℃~10℃ (to prevent heat-sensitive components from becoming ineffective);

[0178] Speed: 8000~12000r / min;

[0179] Crushing time: 30 to 60 minutes per batch.

[0180] Nanoscale sieving instrument

[0181] Pore ​​diameter: 50-100 nm;

[0182] Screening efficiency: ≥95% (ensuring particle size uniformity).

[0183] Low temperature extraction tank

[0184] Temperature control: 40℃~50℃ (to avoid high temperature damage to active ingredients);

[0185] Extraction time: 2 to 3 hours;

[0186] Stirring speed: 100~150r / min.

[0187] V. Implementation Verification

[0188] Efficacy verification

[0189] Cases: 50 patients with bone hyperplasia were selected and applied externally once a day for 4 consecutive weeks;

[0190] Results: The pain scores of 90% of patients were reduced by ≥50%, and the bone deformity was significantly improved in 36% of patients.

[0191] Transdermal absorption rate test

[0192] Methods: Franz diffusion cell method was used;

[0193] Results: The transdermal absorption rate of the nano-scale composition reached 85%, which was three times higher than that of traditional plasters.

[0194] 6. Summary of Technical Advantages

[0195] Nanoscale preparation technology: particle size ≤100nm, drug loading capacity increased by 60 times, and transdermal absorption efficiency significantly enhanced;

[0196] Low temperature process protection: prevent heat-sensitive ingredients (such as volatile oils and enzymes) from becoming ineffective;

[0197] Targeted drug delivery: precise release at the lesion site is achieved through nano-drug-carrying promoters;

[0198] Comprehensive conditioning: combining external application with internal conditioning to dredge meridians, remove blood stasis and toxins, and repair bones.

[0199] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any changes or substitutions that can be easily conceived by a person skilled in the art within the technical scope disclosed in the present invention should be included in the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be based on the scope of protection of the claims.

Claims

1. A Chinese medicine composition for external application, internal regulation, expelling dampness and removing cold, and strengthening bones, comprising a powder and an extract, characterized in that: Made from the following raw materials in the following weight ranges: 290-350g of Panax notoginseng, 1500-1700g of ginger, 280-330g of Millettia reticulata, 190-240g of Salvia miltiorrhiza, 260-310g of Clematis chinensis, 290-350g of Angelica sinensis, 380-430g of Radix schizonepetae, 390-430g of Herba Lycopodii, 430-510g of Rhizoma Cynanchi, 500-620g of cinnamon twig, 270-350g of Pinellia ternata, 380-420g of Pueraria root, 530-620g of Licorice root, 300-300g of Scutellaria baicalensis. 50-450 grams, Eucommia ulmoides 520-610 grams, Cynomorium songaricum 260-320 grams, Earthworm 600-700 grams, Gastrodia elata 420-450 grams, Myrrh 210-280 grams, Drynaria fortunei 300-400 grams, Borneolum 230-310 grams, Alum 230-350 grams, Ganoderma lucidum 450-550 grams, Sambucus 670-760 grams, Mint 500-600 grams, Yellow rice wine 800-950 grams, Rice vinegar 800-950 grams; The composition is prepared into plant-extracted health-care essence powder through nano-scale pulverization and low-temperature extraction processes, with a particle size of ≤100 nm, a drug loading amount that is 60 times the conventional amount, and a nano-drug loading transdermal enhancer is added.

2. The Chinese medicine composition for external application, internal regulation, expelling dampness and removing cold, and strengthening bones comprising the powder and extract according to claim 1, characterized in that: The nano drug-carrying transdermal enhancer is at least one of liposomes, nano-microemulsions or chitosan derivatives, and its mass accounts for 1% to 5% of the total amount of the composition.

3. The Chinese medicine composition for external application, internal regulation, expelling dampness and removing cold, and strengthening bones comprising the powder and extract according to claim 1, characterized in that: The preparation method of the plant extract health-promoting essence powder comprises the following steps: (1) 27 Chinese medicinal herbs were weighed in proportion and ultrafinely ground into nano-sized particles at low temperature; (2) adding yellow rice wine and rice vinegar for low-temperature extraction, filtering and concentrating to obtain essence powder; (3) Mix the nano-TCM powder and the essence powder, add the nano-drug-carrying transdermal enhancer, stir evenly and seal the mixture.

4. Use of the traditional Chinese medicine composition for external application, internal regulation, expelling dampness and removing cold, and bone health care containing the powder and extract according to claim 1 in the preparation of a drug for treating bone diseases, characterized in that: The bone diseases include bone hyperplasia, old fractures, femoral head necrosis, muscle and bone pain, traumatic injuries and numbness of the limbs.

5. A method for external application of the Chinese medicine composition for internal regulation of dampness, cold and bone health care containing the powder and extract according to claim 1, characterized in that: The following steps are involved: (1) Prepare the medicinal solution: Pour the essence powder into a clean container, add the permeate and appropriate amount of hot water, and stir evenly until it becomes a paste. The permeate is a mixture of yellow wine and rice vinegar; (2) Apply and wrap: Apply the liquid medicine evenly to the painful area, cover with plastic wrap, and use for 30 minutes for the first time and 40 to 60 minutes each time thereafter; (3) Cleaning the residue: After removing the plastic wrap, use a card to scrape off the remaining liquid, wipe it clean with a dry towel, and do not use water to clean it; (4) Usage cycle: once a day for the first three days, then twice a week, and adjust the course of treatment according to physical condition and condition; (5) Dietary taboos: Do not eat spicy food, irritating food, seafood and alcohol during the conditioning period.

6. The external application conditioning method according to claim 5, characterized in that: During the conditioning process, local fever or slight tingling may occur, which is a normal phenomenon of drug action and there is no need to interrupt treatment.

7. The Chinese medicine composition for external application, internal regulation, expelling dampness and removing cold, and strengthening bones comprising the powder and extract according to claim 1, characterized in that: The mass ratio of ginger to mint in the raw materials is (1500-1700):(500-600), and the mass ratio of cassia twig to liquorice is (500-620):(530-620), so as to optimize transdermal absorption and anti-inflammatory and analgesic effects.

8. A preparation device for the Chinese medicine external application, internal regulation, dehumidification, cold removal and bone health-promoting composition containing the medicine powder and extract according to claim 1, characterized in that: The device comprises a low-temperature ultrafine pulverizer, a nano-level sieving instrument, a low-temperature extraction tank and a mixing agitator. The device is used to realize nano-processing of raw materials and low-temperature concentration of essence powder.

9. The preparation device according to claim 8, characterized in that: The pulverizing temperature of the low-temperature ultrafine pulverizer is controlled at -20°C to 10°C, and the aperture of the sieve is 50 to 100 nm.