Lactoferrin with strong iron absorption capability as well as preparation method and application of lactoferrin

By methacrylation and gradient dialysis of low-iron lactoferrin, its iron saturation content is increased, which solves the problem of insufficient iron absorption capacity of existing lactoferrin, achieves stronger iron absorption capacity and antibacterial effect, and is suitable for the treatment of iron overload diseases.

CN120718138APending Publication Date: 2025-09-30MAIRUN MEDICAL TECHNOLOGY (SHAOXING) CO LTD
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Patent Information

Application Number
CN202411970254.6
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-03-28
Publication Date
2025-09-30

AI Technical Summary

Technical Problem

The iron saturation content of existing lactoferrin is low, resulting in insufficient iron absorption capacity, inability to effectively and quickly reduce the iron content in the microenvironment, inability to effectively treat iron overload diseases and insufficient antibacterial ability.

Method used

By methacrylating low-iron lactoferrin and adjusting the PBS solution concentration during dialysis with a gradient, the iron removal efficiency is increased, the iron binding sites of lactoferrin are enhanced, and its iron absorption capacity is improved.

Benefits of technology

The iron saturation content of lactoferrin is increased to more than 10 mg/g, which can quickly reduce the iron content in the microenvironment and effectively treat iron overload diseases such as myocardial ischemia-reperfusion, renal ischemia-reperfusion and cerebral infarction, and has stronger antibacterial ability.

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Abstract

The invention relates to lactoferrin with high iron absorption capacity and a preparation method and application thereof. The iron saturation content of the lactoferrin with high iron absorption capacity is 10 mg / g or above. The lactoferrin with strong iron absorption capability prepared by the invention can quickly reduce the iron content in a microenvironment, and can better reduce iron to treat iron overload diseases, including but not limited to myocardial ischemia reperfusion, kidney ischemia reperfusion, cerebral infarction and other diseases; meanwhile, the better iron deprivation and antibacterial capacity is achieved.
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Citation Information

Patent Citations

  • Method of preparing low-iron lactoferrin

    CN102459328B