Painless needleless injection system based on low-intensity laser treatment technology

Abstract

The invention relates to the field of medical instruments, in particular to a painless needleless injection system based on a low-intensity laser treatment technology. The needle-free injection system comprises a needle-free injection module, a low-intensity laser irradiation module and a control unit, low-intensity laser treatment is fused into needle-free injection, a low-intensity laser spot and a liquid medicine outlet coincide at the injection position, space coordination and time synchronization of low-intensity laser and liquid medicine jet flow at the injection position are achieved, and the injection effect is improved. The light biological regulation effect of low-intensity laser is cooperatively utilized, instantaneous pain and inflammatory response caused by high-speed liquid medicine jet flow are effectively inhibited, discomfort of a patient is greatly relieved by promoting local blood circulation, easing pain, resisting inflammation and accelerating tissue repair, the limitation that an existing needle-free injection system cannot achieve complete painless is overcome, and the application range of the needle-free injection system is widened. And the whole system is reasonable in structure and easy to integrally produce, and the painless injection performance and patient compliance are effectively improved on the basis of ensuring the convenient use experience of original needle-free injection.

Description

Technical Field

[0001] The present invention relates to the field of medical devices, and in particular to a painless needle-free injection system based on low-intensity laser treatment technology. Background Art

[0002] Needle-free injection is an innovative alternative to traditional injection methods. It uses driving mechanisms such as springs, high-pressure gas, laser pulses or electromagnetic force to generate a high-speed jet of liquid medicine to penetrate the surface of the skin and deliver the drug to the subcutaneous or muscle tissue. The core advantage of this technology is that it eliminates the fear and potential risk of medical cross-infection brought about by traditional needle puncture.

[0003] The pain of traditional needle injections primarily stems from direct mechanical stimulation and micro-trauma inflicted by the needle tip on the skin and the densely distributed nerve endings beneath it during puncture. In contrast, needle-free injections use a high-speed fluid stream rather than a solid needle to enter the tissue, theoretically causing far less overall disturbance and damage to tissue structure than traditional needle injections. While the injection process is typically completed in a very short time, making the overall pain experience far less than with traditional methods, needle-free injections are still not completely painless.

[0004] The sources of pain in needle-free injection systems are multifaceted, including: (1) the physical impact and pressure generated by the instantaneous contact of the high-speed drug jet with the skin; (2) the rapid diffusion and accumulation of the drug solution after the drug jet enters the subcutaneous space, which leads to increased tension in the local tissue and mechanical stress on the cells; (3) the physical and chemical properties of some drug solutions themselves (such as pH, osmotic pressure or irritating ingredients) may cause chemical stimulation to the surrounding tissues, further triggering or exacerbating pain or burning sensations. Therefore, even without a needle, needle-free injection cannot completely avoid all pain perception; in addition, individual physiological differences lead to significant differences in their perception thresholds and tolerance to pain, which means that some patients may still experience a certain degree of discomfort even with needle-free injection.

[0005] The information disclosed in the background technology section of the present invention is only intended to deepen the understanding of the general background technology of the present invention, and should not be regarded as an admission or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. Summary of the Invention

[0006] In view of the shortcomings of the existing technology, the present invention proposes a painless needle-free injection system based on low-intensity laser therapy technology, which aims to further reduce or eliminate the residual pain and discomfort during the needle-free injection process.

[0007] The present invention provides a painless needle-free injection system based on low-intensity laser therapy technology, which adopts the following technical solutions:

[0008] The needleless injection module is configured to deliver a liquid medicine to a subcutaneous or muscular tissue of an injection site in a jet form;

[0009] The low-intensity laser irradiation module is configured to irradiate the injection site with a low-intensity laser before, during and after the needleless injection, the low-intensity laser having a wavelength between 600-1000 nm;

[0010] The control unit is configured to control the needleless injection module to inject and to control the low-intensity laser irradiation module to irradiate.

[0011] Optionally, the low-intensity laser irradiation is performed on the injection site for 2-15 seconds before the needleless injection.

[0012] Optionally, the low-intensity laser irradiation is performed on the injection site for 2-15 seconds after the needleless injection.

[0013] Optionally, the needleless injection module comprises a housing, a laser generator one and an elastic membrane, the housing is provided with a medicine storage cavity and a pressure cavity, the medicine storage cavity is configured to store the liquid medicine, the housing is provided with a nozzle at the bottom, the nozzle is communicated with the medicine storage cavity; the pressure cavity is located above the medicine storage cavity, the elastic membrane is arranged at the communication between the pressure cavity and the medicine storage cavity and separates the pressure cavity and the medicine storage cavity, the pressure cavity is filled with a liquid, the laser generator one is configured to emit a mid-infrared laser to the pressure cavity under the control of the control unit.

[0014] Optionally, the top of the pressure cavity is provided with a laser window.

[0015] Optionally, the housing is provided with a jet channel, the jet channel is arranged below the medicine storage cavity and is provided with a one-way valve between the jet channel and the medicine storage cavity, the one-way valve is configured to allow the liquid medicine in the medicine storage cavity to flow only from the medicine storage cavity to the jet channel in a one-way manner, and the nozzle is communicated with the jet channel.

[0016] Optionally, the housing is provided with a medicine supplementing device, the medicine supplementing device is configured to supplement the medicine to the medicine storage cavity.

[0017] Optionally, the low-intensity laser irradiation module comprises a laser generator two, a lens and a reflecting mirror, the housing is provided with a laser channel, the laser channel is bent at the bottom towards the nozzle, the reflecting mirror is arranged at the bending position of the laser channel, the lens is arranged at the bottom of the laser channel, and the laser generator two is configured to emit a low-intensity laser to the laser channel under the control of the control unit.

[0018] Optionally, the top of the housing is provided with an upper connecting piece, the upper connecting piece is provided with a first through hole and a second through hole, the first through hole is communicated with the laser channel, and the second through hole is communicated with the laser window.

[0019] Optionally, the laser generator one, the laser generator two and the control unit are integrated in the housing.

[0020] The beneficial effects of the present invention are: a painless needle-free injection system based on low-intensity laser treatment technology of the present invention integrates low-intensity laser treatment into needle-free injection, so that the low-intensity laser spot coincides with the medicine outlet at the injection site, and realizes the spatial coordination and time synchronization of the low-intensity laser and the medicine jet at the injection site. The injection site is irradiated with low-intensity laser before, during and after the injection, and the photobiomodulation effect of the low-intensity laser is synergistically utilized to effectively inhibit the instantaneous pain and inflammatory response caused by the high-speed medicine jet. By promoting local blood circulation, analgesia, anti-inflammation and accelerating tissue repair, the patient's discomfort is greatly reduced, and the limitations of the existing needle-free injection system that cannot achieve complete painlessness are overcome. In addition, the entire system has a reasonable structure and is easy to integrate and produce. On the basis of ensuring the original convenient use experience of needle-free injection, the painless injection performance and patient compliance are effectively improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0022] Figure 1 This is an overall schematic diagram of a painless needle-free injection system based on low-intensity laser therapy technology of the present invention;

[0023] Figure 2 This is a schematic diagram of the main structure of a needle-free injection module in a painless needle-free injection system based on low-intensity laser therapy technology of the present invention;

[0024] Figure 3 for Figure 2 Internal structure diagram;

[0025] Figure 4 for Figure 2 Exploded view of

[0026] Figure 5 for Figure 2 Structural diagram from another angle;

[0027] In the picture:

[0028] 1. Nozzle; 2. First sub-shell; 3. Lens; 4. Reflector; 5. One-way valve; 6. Second sub-shell; 7. Side connector; 8. Elastic membrane; 9. Third sub-shell; 10. Sealing ring; 11. Laser window; 12. Upper connector; 13. Laser generator 1; 14. Laser generator 2; 15. Control unit.

[0029] 01. Drug storage chamber; 02. Pressure chamber; 03. Jet channel; 04. Liquid supply channel; 05. Laser channel. DETAILED DESCRIPTION

[0030] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts shall fall within the scope of protection of the present invention.

[0031] like Figures 1 to 5 As shown, an embodiment of the present invention provides a painless needle-free injection system based on low-intensity laser therapy technology, which includes a needle-free injection module, a low-intensity laser irradiation module and a control unit 15.

[0032] The needle-free injection module is configured to deliver the drug solution to the subcutaneous or muscle tissue at the injection site in the form of a jet; the low-intensity laser irradiation module is configured to perform low-intensity laser irradiation on the injection site before, during and after the needle-free injection, and the wavelength of the low-intensity laser is between 600 and 1000 nm; the control unit 15 is configured to control the injection of the needle-free injection module and control the irradiation of the low-intensity laser irradiation module.

[0033] It is understandable that compared to traditional needle injection, needle-free injection enters the tissue through a high-speed liquid flow rather than a solid needle. In theory, the overall disturbance and damage to the tissue structure is far less than that of traditional needle injection, making the overall pain much lower than the traditional method. However, needle-free injection still cannot be completely painless. Therefore, in-depth research and development of technical solutions aimed at further reducing the pain of needle-free injection systems have great practical significance and application value. The reduction in pain can not only effectively improve the treatment compliance of patients (especially patients with chronic diseases who require long-term and frequent injections, such as insulin injections for diabetic patients), but also significantly reduce the psychological burden of patients. At the same time, lower injection pain will expand the potential applicable population of needle-free injection technology, making it a better choice for children, people who are sensitive to pain, or when sensitive areas need to be injected.

[0034] The solution of this embodiment integrates low-intensity laser therapy with a wavelength between 600 and 1000 nm into needle-free injection, so that the low-intensity laser spot coincides with the drug outlet at the injection site. The injection site is irradiated with low-intensity laser before, during and after the injection. The photobiomodulation effect of the low-intensity laser is utilized to effectively combat the instantaneous pain and subsequent discomfort caused by factors such as the physical impact of the high-speed drug jet, tissue traction and drug stimulation, thereby greatly improving the comfort of needle-free injection and hopefully achieving a nearly painless injection experience.

[0035] At the same time, low-intensity laser therapy has the biological effects of promoting local blood circulation, anti-inflammation and accelerating tissue repair. By precisely applying the laser to the site where the drug jet penetrates and diffuses, it can effectively reduce the local inflammatory response and tissue edema that may be caused by injection, accelerate the healing of subcutaneous micro-damage, thereby reducing complications such as congestion, swelling or pain after injection, and shortening recovery time; low-intensity laser irradiation can promote local blood circulation, which may help improve the absorption and distribution of drugs, thereby improving the accuracy and efficacy of drug administration.

[0036] This invention significantly reduces injection pain and accelerates tissue recovery, significantly increasing patient enthusiasm and tolerance for injection treatments. This is particularly true for diabetic patients who require daily or even multiple insulin injections. It also allows needle-free injection technology to be more effectively applied to specific populations that are highly sensitive to pain, such as children and the elderly. Furthermore, low-intensity laser therapy itself is a non-invasive, low-energy treatment modality that is generally safe and reliable when used within prescribed parameters. It does not cause thermal damage to tissues or other side effects, ensuring the overall safety of the system.

[0037] In a further embodiment, preferably, the injection site is irradiated with low-intensity laser for 2-15 seconds before the needle-free injection, and the injection site is irradiated with low-intensity laser for 2-15 seconds after the needle-free injection, which can improve drug absorption, effectively reduce pain and accelerate tissue recovery.

[0038] In a further embodiment, the needle-free injection module includes a shell and a driving structure. A drug storage chamber 01 is opened in the shell, and the drug storage chamber 01 stores liquid medicine. A nozzle 1 is provided at the bottom of the shell, and the nozzle 1 is connected to the drug storage chamber 01. The nozzle 1 provides a flow channel for the liquid medicine, and its end provides a liquid medicine outlet with an outlet diameter of 25 to 1000 μm. The nozzle 1 can be disassembled for easy replacement and maintenance.

[0039] The driving mechanism is configured to drive the liquid medicine in the drug storage chamber 01 to be delivered to the subcutaneous or muscle tissue at the injection site in the form of a jet under the control of the control unit 15. The driving mechanism can be driven by laser, spring, high-pressure gas, or electromagnetic force to drive the injection of the liquid medicine in the drug storage chamber 01.

[0040] In a preferred embodiment of the present invention, the drive structure utilizes laser pulse drive to drive the injection of the drug solution. In this embodiment, the drive structure includes a laser generator 13 and an elastic membrane 8. A pressure chamber 02 is disposed within the housing, located above the drug storage chamber 01. The elastic membrane 8 is positioned at the connection between the pressure chamber 02 and the drug storage chamber 01, thereby separating the two chambers. The pressure chamber 02 is filled with a liquid, which can be water. The laser generator 13 is configured to emit a mid-infrared laser into the pressure chamber 02 under the control of a control unit 15.

[0041] In this embodiment, when an injection is required, laser generator 13 emits a mid-infrared laser into pressure chamber 02. Leveraging the strong absorption properties of mid-infrared laser light and water, the laser energy is converted into high-pressure steam bubbles. The shock waves generated by the expansion of these bubbles deform elastic membrane 8, thereby ejecting the drug solution within drug reservoir 01 into the subcutaneous tissue in the form of high-speed microjets. Elastic membrane 8 is made of a polymer material such as silicone rubber or polyurethane. In other embodiments, it is feasible to replace elastic membrane 8 with other structures capable of transmitting bubble pressure, such as pistons.

[0042] Furthermore, to ensure that the mid-infrared laser can successfully irradiate the liquid in pressure chamber 02, a laser window 11 is provided at the top of pressure chamber 02. Laser window 11 is made of a transparent material such as sapphire or fluoride glass that is permeable to mid-infrared laser light. A sealing ring 10 is provided at the connection between pressure chamber 02 and laser window 11 to prevent leakage. Sealing ring 10 is made of rubber. In other embodiments, other materials, such as adhesives, may be used to achieve a seal between laser window 11 and pressure chamber 02.

[0043] Furthermore, in order to make the flow of the medicine liquid more smooth and controllable, a jet channel 03 is provided in the shell, and the jet channel 03 is provided below the medicine storage chamber 01, and a one-way valve 5 is provided between the medicine storage chamber 01. The one-way valve 5 is configured so that the medicine liquid in the medicine storage chamber 01 can only flow in one direction from the medicine storage chamber 01 to the jet channel 03, and the nozzle 1 is connected to the jet channel 03.

[0044] In a further embodiment, a drug supply device is provided on the housing, and the drug supply device is configured to replenish drugs to the drug storage chamber 01. Specifically, the drug supply device includes a side connector 7 and a liquid supply channel 04. The liquid supply channel 04 is provided on the housing and connected to the drug storage chamber 01. The side connector 7 is provided on the side wall of the housing, and the interior of the side connector 7 is connected to the liquid supply channel 04. The top of the side connector 7 is provided with an interface that can be connected to an external container storing liquid medicine to ensure the supply of external liquid medicine to the spray head 1.

[0045] A one-way valve 5 is also provided in the liquid supply channel 04 . The one-way valve 5 is configured so that the liquid medicine can only flow from the side connector 7 to the liquid medicine storage chamber 01 , thereby preventing liquid medicine from being sucked back.

[0046] In a further embodiment, the low-intensity laser irradiation module includes a second laser generator 14, a lens 3 and a reflector 4. A laser channel 05 is provided in the shell. The bottom of the laser channel 05 is bent toward the nozzle 1. The reflector 4 is provided at the bend of the laser channel 05. The lens 3 is provided at the bottom of the laser channel 05. The second laser generator 14 is configured to emit low-intensity laser to the laser channel 05 under the control of the control unit 15.

[0047] The laser generator 2 14 emits a low-intensity laser. After being collimated, the low-intensity laser enters the laser channel 05 and is reflected by the reflector 4, where the optical path is deviated. The laser is incident on the lens 3 obliquely forward and then converted into divergent light by the lens 3. The light spot irradiates the injection site in a continuous or pulsed form. The light spot acts evenly on the tissue around the injection point, stimulating a local photobiological effect.

[0048] Laser generator 1 13 and laser generator 2 14 are controlled by a control unit 15. The control unit 15 controls laser generator 13 and laser generator 2 14 to work independently. The control unit 15 controls and coordinates laser generator 2 14 to perform low-intensity laser irradiation on the injection site before, during and after needle-free injection.

[0049] In a further embodiment, an upper connector 12 is provided at the top of the housing. Upper connector 12 seals the top of the housing and is provided with a first through-hole and a second through-hole. The first through-hole communicates with laser channel 05, and the second through-hole communicates with laser window 11. Laser generator 13 and laser generator 2 14 can be connected to upper connector 12 via a light guide arm or optical fiber.

[0050] In this embodiment, the upper connector 12 is provided to seal the housing and facilitate connection with laser generator 1 13, laser generator 2 14, light guide arms, optical fibers, and other structures. For ease of maintenance and replacement, the upper connector 12 and the housing are removable.

[0051] Furthermore, to facilitate processing, manufacturing and structural setting, the shell includes a first sub-shell 2, a second sub-shell 6 and a third sub-shell 9 connected in sequence from bottom to top, the nozzle 1 is arranged at the bottom of the first sub-shell 2, and the jet channel 03 is arranged inside the first sub-shell 2; the medicine storage chamber 01 and the liquid supply channel 04 are arranged in the second sub-shell 6, the side connecting member 7 is arranged on the side wall of the second sub-shell 6, the pressure chamber 02 is arranged in the third sub-shell 9, and the upper connecting member 12 is arranged at the top of the third sub-shell 9.

[0052] In one embodiment, the first partial shell 2 , the second partial shell 6 , and the third partial shell 9 may be connected by using adhesive or the like.

[0053] In other embodiments, to facilitate assembly and maintenance, the first partial shell 2 , the second partial shell 6 , and the third partial shell 9 are detachably connected, specifically, they are directly connected and fixed via a threaded structure.

[0054] Furthermore, the materials of the nozzle 1 , the first sub-shell 2 , the second sub-shell 6 , the third sub-shell 9 , the upper connecting member 12 , and the side connecting member 7 are polymer, metal, or ceramic.

[0055] Further, the control unit 15, the laser generator 13 and the laser generator 14 can be integrated into a housing, and a visual operation component such as an operation panel is arranged on the housing. The overall operation process is similar to that of the existing needleless injector, and is easy to master and use.

[0056] The above description is merely preferred embodiments of the present application, and is not intended to limit the present application. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A painless needle-free injection system based on low-intensity laser therapy technology, characterized in that: include: a needle-free injection module configured to deliver a drug solution in the form of a jet to subcutaneous or muscle tissue at an injection site; A low-intensity laser irradiation module is configured to irradiate the injection site with a low-intensity laser before, during, and after the needle-free injection, wherein the wavelength of the low-intensity laser is between 600 and 1000 nm; The control unit is configured to control the injection of the needle-free injection module and the irradiation of the low-intensity laser irradiation module.

2. The painless needle-free injection system based on low-intensity laser therapy technology according to claim 1, characterized in that: Prior to needle-free injection, the injection site is irradiated with a low-intensity laser for 2-15 seconds.

3. The painless needle-free injection system based on low-intensity laser therapy technology according to claim 1, characterized in that: After the needle-free injection, low-intensity laser light is applied to the injection site for 2-15 seconds.

4. The painless needle-free injection system based on low-intensity laser therapy technology according to claim 1, characterized in that: The needle-free injection module includes a shell, a laser generator and an elastic membrane. A drug storage chamber and a pressure chamber are provided in the shell. The drug storage chamber stores liquid medicine. A nozzle is provided at the bottom of the shell and is connected to the drug storage chamber. The pressure chamber is located above the drug storage chamber. The elastic membrane is provided at the connection between the pressure chamber and the drug storage chamber and blocks the pressure chamber and the drug storage chamber. The pressure chamber is filled with liquid. The laser generator is configured to emit mid-infrared laser to the pressure chamber under the control of the control unit.

5. The painless needle-free injection system based on low-intensity laser therapy technology according to claim 4 is characterized in that: A laser window is provided on the top of the pressure chamber.

6. The painless needle-free injection system based on low-intensity laser therapy technology according to claim 4, characterized in that: A jet channel is provided in the shell, which is provided below the medicine storage chamber and a one-way valve is provided between the jet channel and the medicine storage chamber. The one-way valve is configured so that the medicine liquid in the medicine storage chamber can only flow in one direction from the medicine storage chamber to the jet channel, and the nozzle is connected to the jet channel.

7. The painless needle-free injection system based on low-intensity laser therapy technology according to claim 4, characterized in that: The shell is provided with a medicine supply device, which is configured to replenish medicine into the medicine storage cavity.

8. The painless needle-free injection system based on low-intensity laser therapy technology according to claim 4, characterized in that: The low-intensity laser irradiation module includes a second laser generator, a lens and a reflector. A laser channel is provided in the shell. The bottom of the laser channel is bent toward the nozzle. The reflector is provided at the bend of the laser channel. The lens is provided at the bottom of the laser channel. The second laser generator is configured to emit low-intensity laser into the laser channel under the control of the control unit.

9. The painless needle-free injection system based on low-intensity laser therapy technology according to claim 5, characterized in that: An upper connecting piece is provided on the top of the shell. A first through hole and a second through hole are opened on the upper connecting piece. The first through hole is connected to the laser channel, and the second through hole is connected to the laser window.

10. The painless needle-free injection system based on low-intensity laser therapy technology according to claim 8, characterized in that: The first laser generator, the second laser generator and the control unit are integrated in the housing.

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