Universal rat enema device

Abstract

The invention discloses a universal rat enema device, and relates to the technical field of rat enema experiments.The universal rat enema device comprises an injector pump, the injector pump and a control module, a liquid feeding pipe is arranged at the output end of the injector pump, and a liquid outlet spray head is fixedly connected to the end, away from the injector pump, of the liquid feeding pipe; the liquid outlet spray head is of an oval hollow porous structure, a support is arranged on the lower portion of the end, close to the liquid outlet spray head, of the liquid feeding pipe, and a fixing mechanism is arranged on the upper portion of the support and arranged on the outer side of the liquid feeding pipe and comprises a fixing ring. The fixing mechanism is combined to support and fix the body of the rat, so that the pressure in the abdominal cavity of the rat is properly increased, the local rapid expansion of the intestinal tract caused by direct injection of liquid is reduced, the tissue damage or perforation risk is reduced, the consistency and safety of enema operation are improved, and the device has the characteristic of improving the repeatability of experimental data.

Description

Technical Field

[0001] The invention relates to the technical field of rat enema experiments, in particular to a universal rat enema device. Background Art

[0002] In existing rat enema experiments, the procedure is usually completed by directly inserting an enema tube into the rat's anus and injecting liquid. However, in actual operation, the rat's intra-abdominal pressure state is uncontrollable, which can easily lead to the following problems: First, when the abdominal cavity pressure is insufficient, the intestinal wall has low resistance to the perfusion fluid, which can easily cause abnormal swelling in the area, causing micro-injury or even perforation;

[0003] On the other hand, if the intra-abdominal pressure is too high or rises too quickly, it may cause stress response, intestinal dysfunction and data deviation in rats;

[0004] In addition, due to the large individual differences in intra-abdominal pressure, failure to monitor and control it in real time can easily lead to poor experimental repeatability and decreased accuracy of the results. This problem is particularly prominent under conditions of large perfusion volumes or fast perfusion speeds.

[0005] Therefore, there is an urgent need for an enema device that can monitor and control changes in intraperitoneal pressure in real time to ensure animal safety and improve the reliability and comparability of experimental data. The existing publication number is.

[0006] In view of this, it is necessary to develop a rat enema device that can regulate the intra-abdominal pressure in real time through the linkage between external pressure and internal air pressure and has an automatic protection mechanism, so as to achieve precise control of intra-abdominal pressure, reduce the risk of animal injury, and improve the data consistency and result accuracy during the enema experiment. Summary of the Invention

[0007] The object of the present invention is to provide a universal rat enema device to solve the problems raised in the above background technology.

[0008] In order to solve the above technical problems, the present invention provides the following technical solutions: a universal rat enema device, comprising a syringe pump and a control module, wherein the syringe pump is electrically connected to the control module, a liquid delivery tube is provided at the output end of the syringe pump, an end of the liquid delivery tube away from the syringe pump is fixedly connected to a liquid discharge nozzle, the liquid discharge nozzle is an elliptical hollow porous structure, a bracket is provided at the lower portion of one end of the liquid delivery tube close to the liquid discharge nozzle, a fixing mechanism is provided at the upper portion of the bracket, and the fixing mechanism is provided on the outer side of the liquid delivery tube;

[0009] The fixing mechanism includes a fixing ring;

[0010] The fixing ring is arranged on the outside of the liquid feeding tube, and a circular hole is provided in the middle of the fixing ring, and the diameter of the circular hole is larger than the outer diameter of the liquid feeding tube. A connecting plate that can be deflected relative to the fixing ring is provided on the outside of the fixing ring, and the connecting plate is provided with an enclosing mechanism and a squeezing mechanism;

[0011] The enclosing mechanism includes an arc-shaped plate and an elastic membrane. The arc-shaped plate is an arc-shaped hollow structure, and a plurality of mounting openings are opened on the arc-shaped plate. The elastic membrane is arranged inside the mounting openings.

[0012] The squeezing mechanism comprises a pressing roller, the outer wall of the pressing roller contacts the outer wall of the liquid feeding tube, and the pressing roller can move relative to the fixing ring.

[0013] According to the above technical solution, the outer wall of the fixing ring is hinged to the outer wall of the bracket, and connecting plates are provided on the upper and lower sides of the fixing ring. The connecting plate and the fixing ring are connected through a ratchet assembly. In the limited state, the ratchet assembly only allows the connecting plate to deflect toward the side of the fixing ring away from the syringe pump.

[0014] According to the above technical solution, an arc-shaped plate is provided on each of the connecting plates, and the outer walls of the convex sides of the two arc-shaped plates are fixedly connected to the surfaces of the two connecting plates close to each other, and the connecting plates are arranged on the concave surface of the fixed ring. Each fixed ring is provided with several connecting plates, and the convex surface of the arc-shaped plate is fixedly connected to the air pipe, and the other end of the air pipe is connected to a micro-flow air pump, and the output end of the micro-flow air pump is connected to the inside of the arc-shaped plate through the air pipe.

[0015] According to the above technical solution, the micro-flow air pump is electrically connected to the control module, and the control module can monitor the output pressure and real-time power of the micro-flow air pump in real time. When the output pressure or power of the micro-flow air pump is greater than the threshold, the control module can shut down the micro-flow air pump.

[0016] According to the above technical solution, a pressure gauge is also provided on the arc plate, which can detect the internal pressure of the arc plate, and the pressure gauge is electrically connected to the control module. When the pressure gauge detects that the internal pressure of the arc plate is greater than the threshold, the micro-flow air pump can be turned off through the control module.

[0017] According to the above technical solution, the extrusion mechanism also includes an electric telescopic rod, one end of the electric telescopic rod intersects with the outer wall of the connecting plate, and the electric telescopic rod is arranged on a side where the two connecting plates are close to each other, and the other end of the electric telescopic rod is hinged to an articulated frame, and the other side of the articulated frame is hinged to a limit strip, one side of the limit strip is hinged to the outer wall of the fixed ring, the outer wall of the articulated frame is rotatably connected to the outer wall of the pressure roller through a bearing, and one side of the articulated frame is fixedly connected to a drive motor, and the output end of the drive motor is fixedly connected to the pressure roller.

[0018] According to the above technical solution, the electric telescopic rod and the driving motor are both electrically connected to the control module, and the movement stroke of the electric telescopic rod and the operating state of the driving motor are both controllable.

[0019] According to the above technical solution, the fixed ring is provided with an electric telescopic rod and a pressure roller, and the liquid delivery pipe is located between the two pressure rollers, and the pressure rollers are made of elastic rubber material.

[0020] Compared with the prior art, the present invention has the following beneficial effects: the present invention is capable of effectively achieving stable positioning and precise enema in the rat's anus region by providing a syringe pump, a liquid delivery tube, a liquid discharge nozzle, a bracket, and a fixing mechanism. The fixing mechanism is combined to support and fix the rat's body, thereby moderately increasing the rat's intra-abdominal pressure, reducing the local rapid expansion of the intestine caused by direct liquid injection, reducing the risk of tissue damage or perforation, and improving the consistency and safety of the enema operation.

[0021] By providing a fixing ring, a connecting plate, an enveloping mechanism, a squeezing mechanism, and a ratchet assembly, the flexible enveloping structure formed by the enveloping mechanism can apply moderate wrapping pressure to the dorsal and ventral regions of rats, and the ratchet assembly can achieve position control. After the operation is completed, the pressure can be released to avoid local blood flow obstruction or tissue damage in rats caused by continuous pressure, thereby improving the comfort and protection of animal experiments.

[0022] By setting up a curved plate, elastic membrane, trachea, micro-flow air pump and pressure gauge, the micro-flow air pump can provide precise and controllable micro-flow gas input, and the pressure gauge can detect internal pressure changes in real time. Combined with the power monitoring results of the micro-flow air pump, the initial intra-abdominal pressure can be calculated in real time, and the pressure conditions can be adjusted according to the individual differences of different rats, thereby improving the accuracy and comparability of experimental data;

[0023] By providing an electric telescopic rod, an articulated frame, a limit bar, a pressure roller and a drive motor, the electric telescopic rod and the electric telescopic mechanism can drive the pressure roller to perform controllable extrusion and deformation of the liquid delivery tube. The rotating motion of the pressure roller can effectively eliminate bubbles on the inner wall of the liquid delivery tube, avoiding gas injection to interfere with the experimental results. At the same time, the foreign body sensation of intubation is reduced after the pressure roller is deformed and rebounded, reducing the risk of intestinal mucosal damage, thereby improving the overall enema experience and the success rate of the experiment. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings:

[0025] Figure 1 It is a schematic diagram of the three-dimensional structure of the present invention;

[0026] Figure 2 It is a schematic diagram of the local structure of the present invention;

[0027] Figure 3 is a schematic diagram of the fixed ring profile structure of the present application;

[0028] Figure 4 is a schematic diagram of the surrounding mechanism structure of the present application;

[0029] Figure 5 is a schematic diagram of the arc-shaped plate internal structure of the present application;

[0030] Figure 6 is a schematic diagram of the extrusion mechanism structure of the present application;

[0031] In the figure: 1, syringe pump; 2, liquid delivery pipe; 3, liquid outlet nozzle; 4, support; 5, fixing mechanism; 501, fixed ring; 502, connecting plate; 503, surrounding mechanism; 504, extrusion mechanism; 505, ratchet assembly; 301, arc-shaped plate; 302, elastic film; 303, air pipe; 304, micro-flow air pump; 305, pressure gauge; 401, electric telescopic rod; 402, hinged frame; 403, limiting strip; 404, compression roller; 405, driving motor. DETAILED DESCRIPTION

[0032] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative work fall within the scope of protection of the present application.

[0033] Please refer to Figure 1-6 The present application provides a technical solution: a general-purpose rat enema device, which comprises a syringe pump 1 and a control module, wherein the syringe pump 1 is electrically connected with the control module, the output end of the syringe pump 1 is provided with a liquid delivery pipe 2, the end of the liquid delivery pipe 2 away from the syringe pump 1 is fixedly connected with a liquid outlet nozzle 3, the liquid outlet nozzle 3 is an elliptical hollow porous structure, the lower part of the end of the liquid delivery pipe 2 close to the liquid outlet nozzle 3 is provided with a support 4, the upper part of the support 4 is provided with a fixing mechanism 5, and the fixing mechanism 5 is arranged on the outer side of the liquid delivery pipe 2.

[0034] The fixing mechanism 5 comprises a fixing ring 501 provided outside the liquid delivery pipe 2, the middle part of the fixing ring 501 is provided with a circular hole, the diameter of the circular hole is larger than the outer diameter of the liquid delivery pipe 2, the outer side of the fixing ring 501 is provided with a connecting plate 502 which can be deflected relative to the fixing ring 501, the connecting plate 502 is provided with a surrounding mechanism 503 and a pressing mechanism 504, the outer wall of the fixing ring 501 is hinged to the outer wall of the support 4, and the upper and lower sides of the fixing ring 501 are both provided with the connecting plate 502, the connecting plate 502 is connected with the fixing ring 501 through a ratchet assembly 505, and the ratchet assembly 505 only allows the connecting plate 502 to be deflected away from the side of the syringe pump 1 of the fixing ring 501 in the limiting state;

[0035] The surrounding mechanism 503 comprises an arc-shaped plate 301 and an elastic film 302, the arc-shaped plate 301 is an arc-shaped hollow structure, a plurality of installation openings are formed in the arc-shaped plate 301, and the elastic film 302 is arranged in the installation opening; the connecting plate 502 is provided with the arc-shaped plate 301, the convex side outer walls of the two arc-shaped plates 301 are fixedly connected with the mutually close surfaces of the two connecting plates 502 respectively, and the connecting plate 502 is arranged on the concave surface of the fixing ring 501; a plurality of connecting plates 502 are arranged on each fixing ring 501, the convex surface of the arc-shaped plate 301 is fixedly connected with an air pipe 303, one end of the air pipe 303 is connected with a micro-flow air pump 304, and the output end of the micro-flow air pump 304 is communicated with the inside of the arc-shaped plate 301 through the air pipe 303;

[0036] During use of the device, the upper limbs of the rat are fixed, the anus of the rat is fully exposed when the rat is fixed, the lower body of the rat is placed on the upper side of the lower arc-shaped plate 301, the lower body of the rat is wrapped by the two arc-shaped plates 301, the lower arc-shaped plate 301 is located between the abdomen of the rat and the rib, and the upper arc-shaped plate 301 is located on the upper side of the back of the rat; at this time, the micro-flow air pump 304 is used for pumping air, air flows into the inside of the arc-shaped plate 301 through the air pipe 303, the elastic film 302 is inflated to wrap the rat as the air pressure in the inside of the arc-shaped plate 301 rises, the intra-abdominal pressure of the rat is increased, the inside of the liquid delivery pipe 2 and the liquid outlet nozzle 3 is emptied of air by the syringe pump 1 outputting the enema liquid, the liquid outlet nozzle 3 and the liquid delivery pipe 2 are fully lubricated and then inserted into the anus of the rat to the rectal area, and the enema liquid is injected; during the process, the intestinal tract is moderately pre-expanded by abdominal and back pressure, the risk of local intestinal wall acute expansion and micro-injury or perforation caused by direct liquid injection during enema is reduced, the anus of the rat is convex, the anal muscle of the rat is more tense due to the increased intra-abdominal pressure, the displacement of the skin during the insertion of the liquid outlet nozzle 3 is reduced, the friction is reduced, the drug liquid is less likely to be discharged outward from the anus due to the tight anal muscle of the rat after the liquid delivery, and the connecting plate 502 is opened outward by removing the limitation of the ratchet assembly 505 after the experiment is completed, so that the rat is not continuously pressed;

[0037] The micro-flow air pump 304 is electrically connected to the control module. The control module can monitor the output pressure and real-time power of the micro-flow air pump 304 in real time. When the output pressure or power of the micro-flow air pump 304 is greater than a threshold, the control module can shut down the micro-flow air pump 304. A pressure gauge 305 is also provided on the curved plate 301. The pressure gauge 305 can detect the internal pressure of the curved plate 301. The pressure gauge 305 is electrically connected to the control module. When the pressure gauge 305 detects that the internal pressure of the curved plate 301 is greater than a threshold, the micro-flow air pump 304 can be shut down by the control module.

[0038] By simultaneously monitoring the output power and output pressure of the micro-flow air pump 304 through the control module and monitoring the internal air pressure of the curved plate 301 through the pressure gauge 305, numerical inaccuracies caused by drift of a single component can be avoided, ensuring that the device can operate safely without damaging the rat's body during operation. In addition, by comparing the power of the micro-flow air pump 304 with the internal pressure value of the curved plate 301, the initial intra-abdominal pressure value of the rat and physiological differences such as the flexibility of the abdominal wall of individual rats can be estimated, thereby improving the accuracy of the experiment.

[0039] Specifically:

[0040] Intra-abdominal pressure estimation formula:

[0041] P_abdomen=k×(P_inner-P_baseline)

[0042] in:

[0043] P_abdomen is the estimated intra-abdominal pressure of rats, unit: Pa;

[0044] P_inner is the internal pressure of the curved plate 301 detected by the pressure gauge 305, unit: Pa;

[0045] P_baseline is the initial airbag internal pressure, unit: Pa;

[0046] k is the calibration coefficient, which is determined through preliminary experiments based on the airbag material, wrapping area, and rat body size;

[0047] The anomaly detection conditions are:

[0048] When any of the following conditions is met, the control module automatically turns off the micro-flow air pump 304:

[0049] P_out>P_out_threshold or W_out>W_out_threshold or P_inner>P_inner_threshold

[0050] in:

[0051] P_out is the output pressure value of the micro-flow air pump 304;

[0052] W_out is the output power value of the micro-flow air pump 304;

[0053] P_inner is the internal pressure value of the curved plate 301 detected by the pressure gauge 305;

[0054] P_out_threshold, W_out_threshold, and P_inner_threshold are the protection thresholds set respectively;

[0055] The squeezing mechanism 504 includes a pressing roller 404, the outer wall of the pressing roller 404 contacts the outer wall of the liquid feeding tube 2, and the pressing roller 404 can move relative to the fixed ring 501. The squeezing mechanism 504 also includes an electric telescopic rod 401, one end of the electric telescopic rod 401 intersects with the outer wall of the connecting plate 502, and the electric telescopic rod 401 is arranged on a side of the two connecting plates 502 close to each other, the other end of the electric telescopic rod 401 is hinged to a hinge frame 402, and the other side of the hinge frame 402 is hinged to a limit strip 403, one side of the limit strip 403 is hinged to the outer wall of the fixed ring 501, and the hinge The outer wall of the connecting frame 402 is rotatably connected to the outer wall of the pressure roller 404 via a bearing. A drive motor 405 is fixedly connected to one side of the articulated frame 402. The output end of the drive motor 405 is fixedly connected to the pressure roller 404. The electric telescopic rod 401 and the drive motor 405 are both electrically connected to the control module. The movement stroke of the electric telescopic rod 401 and the operating state of the drive motor 405 are both controllable. The electric telescopic rod 401 and the pressure roller 404 are both provided on the fixed ring 501. The liquid delivery pipe 2 is located between the two pressure rollers 404. The pressure roller 404 is made of elastic rubber material.

[0056] After the liquid discharge nozzle 3 is inserted into the rat's body, the electric telescopic rod 401 can be started to push the articulated frame 402 so that the pressure rollers 404 clamp the liquid delivery tube 2, thereby causing the two pressure rollers 404 to clamp the liquid delivery tube 2 in the middle and deform. At this time, the drive motor 405 is started or the liquid delivery tube 2 is manually pushed into the rat's body. During this process, the movement of the liquid delivery tube 2 causes the pressure rollers 404 to rotate. During the rotation of the pressure rollers 404, the bubbles adhered to the inner wall of the liquid delivery tube 2 are squeezed to the right, which helps to discharge the bubbles on the inner wall of the liquid delivery tube 2, prevents the bubbles from entering the rat's body through the pressure rollers 404, and avoids interfering with the experimental data.

[0057] At the same time, when the liquid delivery tube 2 passes through the pressure roller 404, the liquid delivery tube 2 is squeezed flat, and the internal liquid is discharged to the right. After the liquid delivery tube 2 passes through the pressure roller 404, the deformation rebounds. At this time, the liquid outlet nozzle 3 is located in the rat body, and the outer side of the liquid outlet nozzle 3 is wrapped by the intestine. The air cannot enter the inside of the liquid delivery tube 2 and the diameter is smaller. Therefore, the foreign body sensation can be kept small before injection, and the influence of adhesions on the surface of the rat intestine is reduced, which helps to improve data accuracy.

[0058] It should be noted that, in this document, relational terms such as first and second, etc., are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprises," "comprising," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that includes a list of elements includes not only those elements but also other elements not explicitly listed, or elements inherent to such process, method, article, or apparatus.

[0059] Finally, it should be noted that the above descriptions are merely preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art will be able to modify the technical solutions described in the aforementioned embodiments or substitute equivalents for some of the technical features. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention shall be included within the scope of protection of the present invention.

Claims

1. A universal rat enema device, comprising a syringe pump (1) and a control module, characterized in that: The syringe pump (1) is electrically connected to the control module, and a liquid delivery pipe (2) is provided at the output end of the syringe pump (1), and a liquid discharge nozzle (3) is fixedly connected to the end of the liquid delivery pipe (2) away from the syringe pump (1), and the liquid discharge nozzle (3) is an elliptical hollow porous structure. A bracket (4) is provided at the lower part of the end of the liquid delivery pipe (2) close to the liquid discharge nozzle (3), and a fixing mechanism (5) is provided on the upper part of the bracket (4), and the fixing mechanism (5) is arranged on the outer side of the liquid delivery pipe (2); The fixing mechanism (5) comprises a fixing ring (501); The fixing ring (501) is arranged on the outside of the liquid delivery tube (2), and a circular hole is provided in the middle of the fixing ring (501), and the diameter of the circular hole is larger than the outer diameter of the liquid delivery tube (2). A connecting plate (502) is provided on the outside of the fixing ring (501) and can be deflected relative to the fixing ring (501), and an enclosing mechanism (503) and a squeezing mechanism (504) are provided on the connecting plate (502); The enclosing mechanism (503) comprises an arc-shaped plate (301) and an elastic membrane (302); the arc-shaped plate (301) is an arc-shaped hollow structure, and a plurality of mounting openings are provided on the arc-shaped plate (301); the elastic membrane (302) is arranged inside the mounting openings; The squeezing mechanism (504) includes a pressing roller (404), the outer wall of the pressing roller (404) contacts the outer wall of the liquid delivery tube (2), and the pressing roller (404) is movable relative to the fixing ring (501).

2. A universal rat enema device according to claim 1, characterized in that: The outer wall of the fixing ring (501) is hinged to the outer wall of the bracket (4), and connecting plates (502) are provided on both the upper and lower sides of the fixing ring (501). The connecting plates (502) are connected to the fixing ring (501) via a ratchet assembly (505). In a limited state, the ratchet assembly (505) only allows the connecting plates (502) to deflect toward the side of the fixing ring (501) away from the syringe pump (1).

3. A universal rat enema device according to claim 2, characterized in that: Each of the connecting plates (502) is provided with an arc-shaped plate (301), and the outer walls of the convex sides of the two arc-shaped plates (301) are fixedly connected to the mutually adjacent surfaces of the two connecting plates (502), and the connecting plates (502) are provided on the concave surface of the fixing ring (501). Each fixing ring (501) is provided with a plurality of connecting plates (502), and the convex surface of the arc-shaped plate (301) is fixedly connected to the air pipe (303), and the other end of the air pipe (303) is connected to the micro-flow air pump (304), and the output end of the micro-flow air pump (304) is connected to the interior of the arc-shaped plate (301) through the air pipe (303).

4. A universal rat enema device according to claim 3, characterized in that: The micro-flow air pump (304) is electrically connected to a control module, and the control module can monitor the output pressure and real-time power of the micro-flow air pump (304) in real time. When the output pressure or power of the micro-flow air pump (304) is greater than a threshold, the control module can shut down the micro-flow air pump (304).

5. A universal rat enema device according to claim 4, characterized in that: The arc-shaped plate (301) is further provided with a pressure gauge (305), which can detect the internal pressure of the arc-shaped plate (301). The pressure gauge (305) is electrically connected to the control module. When the pressure gauge (305) detects that the internal pressure of the arc-shaped plate (301) is greater than a threshold value, the micro-flow air pump (304) can be turned off by the control module.

6. A universal rat enema device according to claim 5, characterized in that: The squeezing mechanism (504) further comprises an electric telescopic rod (401), one end of the electric telescopic rod (401) intersecting with the outer wall of the connecting plate (502), and the electric telescopic rod (401) being arranged on a side of the two connecting plates (502) close to each other, the other end of the electric telescopic rod (401) being hinged to an articulated frame (402), the other side of the articulated frame (402) being hinged to a limit bar (403), one side of the limit bar (403) being hinged to the outer wall of the fixing ring (501), the outer wall of the articulated frame (402) being rotatably connected to the outer wall of the pressing roller (404) via a bearing, one side of the articulated frame (402) being fixedly connected to a driving motor (405), the output end of the driving motor (405) being fixedly connected to the pressing roller (404).

7. A universal rat enema device according to claim 6, characterized in that: The electric telescopic rod (401) and the driving motor (405) are both electrically connected to the control module, and the movement stroke of the electric telescopic rod (401) and the operating state of the driving motor (405) are both controllable.

8. The universal rat enema device according to claim 7, characterized in that: The fixing ring (501) is provided with an electric telescopic rod (401) and a pressure roller (404), and the liquid delivery pipe (2) is located between the two pressure rollers (404). The pressure rollers (404) are made of elastic rubber material.

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