Auxiliary experiment device for pharmacology

Abstract

The invention discloses an auxiliary experimental device for pharmacology, which relates to the technical field of experimental equipment for pharmacology, and is characterized by comprising a sample culture module, a multi-parameter sensor, a data acquisition and analysis module, an environment control module and a man-machine interaction module. The sample culture module provides a suitable environment for a sample, the multi-parameter sensor module integrates multiple sensors to monitor drug action parameters in real time, the data acquisition and analysis module processes and analyzes data, the environment control module maintains a stable environment, and the man-machine interaction module realizes convenient operation and data management. The device can comprehensively monitor the drug action process in real time, the richness and accuracy of experimental data are improved, human intervention is reduced, the experimental efficiency and reliability are improved, and powerful support is provided for pharmacological research.

Description

Technical Field

[0001] The present invention relates to the technical field of pharmacology experimental equipment, and more particularly to an auxiliary experimental device for pharmacology. Background Art

[0002] Pharmacology is the study of drug-body interactions and their mechanisms of action. It primarily encompasses two aspects: pharmacodynamics and pharmacokinetics. The former elucidates the effects and mechanisms of drug action on the body, while the latter investigates the processes of drug absorption, distribution, biotransformation, and excretion within the body, as well as the temporal changes in drug effects and blood concentrations. Pharmacology aims to provide a theoretical basis for elucidating drug effects and mechanisms, improving drug quality, enhancing drug efficacy, and preventing and treating adverse reactions. It also researches and develops new drugs, discovers novel drug uses, and provides experimental data for exploring cellular physiological, biochemical, and pathological processes. The pharmacological approach is experimental, observing the effects of drugs on the body or its components under strictly controlled conditions and analyzing their objective mechanisms.

[0003] Existing pharmacology experiments rely heavily on endpoint methods to detect drug effects. This approach has significant limitations: First, it cannot capture dynamic changes in the drug's course of action, only the final results at the end of the experiment, making it difficult to delve deeper into the drug's mechanism of action. Second, the experimental process is cumbersome and time-consuming, requiring high levels of operator skill and prone to human error.

[0004] With the development of sensor technology, real-time monitoring of drug action processes has become possible. Static culture environments are difficult to simulate the dynamic metabolic process of drugs in organisms, and the lack of real-time monitoring leads to lag. However, there is currently a lack of experimental equipment that applies sensor technology to pharmacological experiments to achieve comprehensive and real-time monitoring of drug action processes. Existing cell and tissue culture methods are difficult to accurately capture subtle changes at the cellular level after drug intervention, and cannot meet the needs of in-depth exploration of drug action mechanisms. Traditional methods are often unable to sensitively reflect cellular responses at the moment and during the continuous process of drug action, and it is difficult to achieve precise and controllable adjustment of culture conditions, which limits the accuracy and repeatability of experimental results.

[0005] Therefore, developing a pharmacology-assisted experimental device capable of real-time monitoring of drug action is crucial. This device, sensitive, precise, and controllable, mimics the dynamic characteristics of the in vivo microenvironment to track drug concentration gradients, cellular mechanical responses, and metabolic signaling networks in real time, enabling sensitive and precise analysis of the temporal and spatial patterns of drug action. This device will better adapt to biomimetic environments, addressing the shortcomings of traditional cell and tissue culture after drug intervention, enabling precise capture and regulation of various indicators during drug action and promoting the development of pharmacological research. Summary of the Invention

[0006] The purpose of this invention is to provide an auxiliary experimental device for pharmacology. By introducing advanced sensor technology, it solves the problem that traditional endpoint detection cannot monitor the drug action process in real time, overcomes the defects of "static monitoring and passive response" of traditional culture systems, and provides more comprehensive and accurate data and technical support for pharmacological research.

[0007] The above technical objectives of the present invention are achieved through the following technical solutions: a pharmacology auxiliary experimental device, including a sample culture module, which provides a suitable culture environment for experimental samples; a modular design, comprising multiple independent culture units, each of which is connected to other modules through a standardized interface; each culture unit is equipped with a vibration device and a culture container, and is equipped with a high-precision micro-pipette to accurately control the addition amount of drugs and various reagents;

[0008] The multi-parameter sensor module is used to monitor the changes of multiple parameters during the drug action process in real time by setting multiple types of sensors in each culture unit;

[0009] The data acquisition and analysis module is installed inside the sample culture module to collect the signals output by the multi-parameter sensor module and process and analyze the data;

[0010] Environmental control module, with temperature control system and humidity control system in each culture unit, to provide stable environmental conditions for sample culture and sensor operation;

[0011] The human-computer interaction module uses a touch screen to provide experimenters with a convenient operation interface and intuitive display of experimental results.

[0012] The present invention is further configured as follows: the multi-type sensors provided in each culture unit of the multi-parameter sensor module include:

[0013] An optical sensor employs charge-coupled device (CCD) imaging technology, coupled with a fluorescence excitation light source and a filter set, with a spatial resolution of up to 1 micron.

[0014] Electrochemical sensors employ microelectrode array technology, with electrodes made of high-purity precious metals and modified at the nanometer level, resulting in a response time of less than 1 second and a detection limit of nanomolar levels.

[0015] Pressure sensor, the pressure sensor is a piezoresistive sensor with a measurement range of 0-10 atmospheres, an accuracy of 0.01% FS, a built-in temperature compensation circuit, and a response frequency of 1000Hz

[0016] The temperature sensor is a platinum resistance sensor with a measurement range of 0-100°C, an accuracy of ±0.01°C, a four-wire measurement method, and a response time of less than 0.5 seconds.

[0017] The present invention is further configured as follows: the data acquisition and analysis module includes a circuit board, a data acquisition card with a 16-bit A / D converter, a signal amplifier with a low-noise and high-gain operational amplifier, a microprocessor with a high-performance embedded processor, and modularly designed data analysis software; the data acquisition card has a sampling frequency of up to 1 MHz and is equipped with USB, Ethernet, and RS485 input and output interfaces; the signal amplifier has a gain range of 1-1000 times and a built-in anti-aliasing filter; the microprocessor has a main frequency of more than 1 GHz and a built-in real-time operating system; the data analysis software supports import and export of multiple data formats, can be connected to Excel and MATLAB tools, and adopts a graphical user interface.

[0018] The present invention is further configured as follows: the environmental control module includes a temperature control system using a PID control algorithm, a humidity control system combining spray humidification and condensation dehumidification, and a gas concentration control system, which can adjust the temperature, humidity and gas concentration of each culture unit; the temperature control system uses heating wires and semiconductor refrigeration chips to adjust the temperature, and the fluctuation range is controlled within ±0.1°C; the humidity control system is equipped with an ultrasonic atomizer and a semiconductor refrigeration chip, and maintains humidity stability through a high-precision humidity sensor; the gas concentration control system includes a gas flow controller, a gas mixer and an external gas cylinder for various gases; the gas flow controller of the gas concentration control system has an accuracy of ±1% FS, which can accurately control the flow of multiple gases and mix them evenly.

[0019] The present invention is further configured as follows: the human-computer interaction module adopts a high-resolution liquid crystal touch display screen and is provided with a multi-function button area, the surface of which is anti-glare treated, and has the functions of experimental parameter setting, experimental process monitoring, data analysis, and data display, query, and export.

[0020] The present invention is further configured as follows: the micro-pipette in the sample culture module is a high-precision pipette with a minimum sample volume of 1 nanoliter and a sample loading accuracy error controlled within ±0.5%; the vibration device uses a vibration motor, and its vibration power and intensity can be controlled and adjusted by the system; the culture container is made of biocompatible polystyrene, which has undergone special surface treatment to promote cell adhesion and growth, has a transmittance of more than 90%, and has different volume specifications of 10 ml, 30 ml, 50 ml, 80 ml, and 100 ml.

[0021] The present invention is further configured as follows: it also includes a box body, the front of the box body is provided with a hinged door, a touch display screen and a multi-function button area are arranged on the front of the box body, the back of the box body is provided with a detachable baffle, the inside of the box body is provided with a closed vertical plate near the baffle, and an ultrasonic nebulizer, a gas mixer and a main exhaust pipe are installed between the vertical plate and the baffle; the gas mixer is provided with a main air inlet connected to an external gas cylinder; the gas mixer is provided with a plurality of air inlet pipes respectively connected to the culture container of each culture unit; the ultrasonic nebulizer is provided with a plurality of atomization pipes connected to each air inlet pipe; the main exhaust pipe is provided with a plurality of exhaust branch pipes connected to the culture container of each culture unit, and the main exhaust pipe passes through the baffle and is provided with an exhaust port; the inside of the box body is provided with longitudinal and transverse staggered partitions between the vertical plate and the door to separate the inside of the box body into a plurality of independent culture units; the semiconductor refrigeration plate is arranged in a ring shape at the bottom of the culture unit, the heating wire is arranged on the side wall of the culture unit, and the vibration motor is arranged at the bottom of the culture unit where the culture container is placed.

[0022] The present invention is further configured as follows: one side of the box door is hinged to the box body through a hinge, the box door is provided with a through observation window corresponding to each culture unit, and the through observation window is provided with a magnetic window panel for sealing and shielding.

[0023] In summary, the present invention has the following beneficial effects: the experimental device of the present invention realizes real-time and all-round monitoring of the drug action process through the multi-parameter sensor module, makes up for the shortcomings of traditional endpoint detection, and provides a powerful tool for in-depth research on the mechanism of action of drugs.

[0024] The device integrates multiple types of sensors, enabling simultaneous acquisition of information on changes in multiple parameters, enhancing the richness and accuracy of experimental data. Its sensitivity, precision, and controllability make it ideally suited to biomimetic environments, addressing the shortcomings of traditional cell and tissue culture following drug intervention and enabling precise capture and regulation of various indicators during drug action. Comprehensive analysis of multi-parameter data using data analysis software can yield more valuable information, providing comprehensive support for pharmacological research. The design of the human-computer interaction module simplifies experimental operations and improves efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 This is a schematic diagram of the module structure of the auxiliary experimental device in an embodiment of the present invention;

[0026] Figure 2 is a functional schematic diagram of a multi-parameter sensor module in an embodiment of the present invention;

[0027] Figure 3 This is a schematic diagram of the main view of the box in an embodiment of the present invention;

[0028] Figure 4 2 is a schematic rear view of the box body in an embodiment of the present invention.

[0029] In the figure: 1. Box body; 2. Box door; 3. Culture container; 4. Window door; 5. Touch screen; 6. Multi-function button area; 7. Baffle; 8. Main air inlet; 9. Exhaust port. DETAILED DESCRIPTION

[0030] The following is combined with Figure 1-4 The present invention is described in further detail.

[0031] Example 1: A pharmacology auxiliary experimental device, such as Figure 1 、 Figure 2 As shown, it includes a sample culture module, which provides a suitable culture environment for experimental samples; it adopts a modular design and contains multiple independent culture units, each of which is connected to other modules through a standardized interface; each culture unit is equipped with a vibration device and a culture container 3, and is equipped with a high-precision micro-pipette to accurately control the addition amount of drugs and various reagents; a multi-parameter sensor module, which is used to monitor the changes of multiple parameters during the drug action process in real time by setting multiple types of sensors in each culture unit; a data acquisition and analysis module, which is installed inside the sample culture module, collects the signals output by the multi-parameter sensor module, and processes and analyzes the data; an environmental control module, which is equipped with a temperature control system and a humidity control system in each culture unit, to provide stable environmental conditions for sample culture and sensor operation; a human-computer interaction module, which uses a touch screen 5 to provide experimenters with a convenient operation interface and intuitive display of experimental results.

[0032] The micropipette in the sample culture module is a high-precision pipette with a minimum sample volume of 1 nanoliter and a sample accuracy error controlled within ±0.5%. The vibration device uses a vibration motor, and its vibration power and intensity can be controlled and adjusted by the system. The vibration motor is set at the position where the culture container 3 is placed in the culture unit, and the vibration is used to achieve uniform mixing of the sample and the drug in the culture container 3. The culture container 3 is made of biocompatible polystyrene and undergoes special surface treatment to promote cell adhesion and growth. The transmittance is over 90%, which meets the detection requirements of optical sensors. The container volume has different volume specifications of 10 ml, 30 ml, 50 ml, 80 ml, and 100 ml according to the scale of the experiment.

[0033] The multi-parameter sensor module has multiple types of sensors installed in each culture unit, including:

[0034] Optical Sensor: The optical sensor utilizes highly sensitive charge-coupled device (CCD) imaging technology, paired with a high-performance fluorescence excitation light source and filter set. The fluorescence excitation light source can generate excitation light at multiple wavelengths to meet the detection requirements of different fluorescent markers. The filter set provides precise wavelength selection, effectively separating excitation and emission light, improving detection sensitivity and specificity. With a spatial resolution of up to 1 micron, the optical sensor enables high-precision, real-time monitoring of the distribution and concentration changes of fluorescent markers in a sample.

[0035] Electrochemical sensors utilize microelectrode array technology, consisting of multiple microelectrodes with different functions, to simultaneously measure multiple electrical parameters in a sample. Electrode materials are made from high-purity precious metals such as platinum and gold, and their surfaces undergo nanoscale surface modification to enhance sensitivity and selectivity. With a response time of less than 1 second and a detection limit down to nanomolar levels, these sensors are capable of monitoring dynamic changes in sample parameters such as ion concentration and pH in real time.

[0036] Pressure Sensor: This high-precision piezoresistive pressure sensor offers a measurement range of 0-10 atmospheres and an accuracy of 0.01% FS. The sensor features a built-in temperature compensation circuit to eliminate the effects of temperature changes on measurement results. With a response frequency of up to 1000 Hz, the pressure sensor can capture instantaneous pressure changes within the culture vessel in real time, making it suitable for experiments involving gas exchange or fluid dynamics.

[0037] Temperature Sensor: The temperature sensor utilizes a high-precision platinum resistance sensor with a measurement range of 0-100°C and an accuracy of ±0.01°C. The sensor utilizes a four-wire measurement system, effectively eliminating the influence of wire resistance on measurement results. With a response time of less than 0.5 seconds, the temperature sensor can quickly and accurately monitor temperature changes in the culture environment.

[0038] The data acquisition and analysis module includes a circuit board, a data acquisition card with a 16-bit A / D converter, a signal amplifier with a low-noise, high-gain operational amplifier, a high-performance embedded microprocessor, and modular data analysis software. The data acquisition card has a sampling frequency of up to 1MHz and can simultaneously acquire signals from multiple sensors. The acquisition card offers a wide range of input and output interfaces, including USB, Ethernet, and RS485, facilitating data transmission and communication with other devices. The signal amplifier has a gain range of 1–1000x and can be flexibly adjusted based on the sensor output signal. A built-in anti-aliasing filter effectively prevents high-frequency noise from interfering with the signal. The microprocessor, with a main frequency exceeding 1GHz, offers powerful computing and data processing capabilities. The microprocessor also includes a built-in real-time operating system, enabling efficient management of data acquisition, processing, and transmission. The data analysis software utilizes a modular design and includes multiple functional modules, including data preprocessing, feature extraction, statistical analysis, and visualization. The software supports importing and exporting data in various formats and seamlessly integrates with common data analysis tools such as Excel and MATLAB. The software features an intuitive graphical user interface, making operation and data analysis easy for experimenters.

[0039] The environmental control module includes a temperature control system using a PID control algorithm, a humidity control system combining spray humidification and condensation dehumidification, and a gas concentration control system, capable of regulating the temperature, humidity, and gas concentration of each culture unit. The temperature control system employs a PID control algorithm, combining heating filaments and semiconductor coolers for temperature regulation. The heating filaments utilize high-power nickel-chromium alloy wires, and the coolers utilize high-performance bismuth telluride semiconductor material. The system is equipped with high-precision temperature sensors, providing real-time feedback on the temperature of the culture modules. By adjusting the operating current of the heating filaments and coolers, the system achieves precise temperature control within a ±0.1°C fluctuation range. The humidity control system utilizes a combination of spray humidification and condensation dehumidification. The humidification unit uses an ultrasonic atomizer to atomize water into tiny particles, which are evenly distributed throughout the culture environment. The dehumidification unit uses semiconductor coolers to remove moisture from the environment through condensation. The system is equipped with a high-precision humidity sensor to monitor the humidity of the culture environment in real time and maintains a stable humidity by adjusting the operating status of the humidification and dehumidification units. The gas concentration control system includes a gas flow controller, a gas mixer, and external gas cylinders for various gases. Gas cylinders are filled with common gases such as oxygen, carbon dioxide, and nitrogen. Mass flow controllers are used, with an accuracy of ±1% FS, to precisely control the flow of each gas. Static mixers are used to evenly mix multiple gases, simulating the in vivo atmosphere.

[0040] The human-computer interaction module utilizes a high-resolution LCD touchscreen display 5 with a multi-function keypad 6 and an anti-glare finish. Experimenters can use the touchscreen to input experimental parameters, such as drug dosage, incubation time, and sensor monitoring frequency. Simultaneously, the screen displays various experimental parameters and analysis results, including sensor data curves and sample images, in real time. It supports experimental parameter setting, experimental process monitoring, data display and analysis, and data storage, query, and export functions. The touchscreen display 5 utilizes a 15-inch, high-resolution LCD with a resolution of up to 1920×1080 and multi-touch functionality. The anti-glare finish ensures clear display of experimental information even in bright light conditions. The user interface features a simple and intuitive design and is divided into multiple areas: experimental parameter setting, experimental process monitoring, and data display and analysis. Experimenters can conveniently input experimental parameters and view experimental parameters and analysis results in real time through the touchscreen display 5. The human-computer interaction module supports data storage, query, and export. Data storage utilizes a large-capacity solid-state drive, capable of storing massive amounts of experimental data. Experimenters can quickly search for required experimental data by entering keywords or time ranges. Data export supports multiple formats, such as Excel and PDF, making it easier for experimenters to conduct subsequent data analysis and report writing. The multi-function keypad 6 serves as a backup for control.

[0041] Example 2, as Figure 3 and Figure 4This embodiment is essentially the same as Example 1, differing in that it further provides a housing 1, integrating the technical solutions of Example 1 into the housing 1 to form an integrated pharmacology auxiliary experimental device. Specifically, the front of the housing 1 is provided with a hinged door 2, a touchscreen display 5 and a multi-function keypad 6 are located on the front of the housing 1, and a removable baffle 7 is located on the back of the housing 1. Inside the housing 1, a closed vertical panel is located near the baffle 7. An ultrasonic nebulizer, a gas mixer, and a main exhaust pipe are installed between the vertical panel and the baffle 7. The gas mixer has a main air inlet 8 connected to an external gas cylinder. The gas mixer has multiple air inlet pipes connected to the culture containers 3 of each culture unit; the ultrasonic nebulizer has multiple atomization pipes connected to each air inlet pipe. Each atomization pipe and air inlet pipe is equipped with a solenoid valve to control the opening and closing and the degree of opening, thereby controlling the air intake. The main exhaust pipe has multiple exhaust branches connected to the culture containers 3 of each culture unit, and the main exhaust pipe passes through the baffle 7 and has an exhaust port 9. Inside the box 1, between the vertical panels and the door 2, there are vertical and horizontal partitions that separate the interior of the box 1 into multiple independent culture units. Each culture unit is independent of each other and can be insulated from heat and moisture. A semiconductor cooling plate is arranged in a ring shape at the bottom of the culture unit, a heating wire is arranged on the side wall of the culture unit, and a vibration motor is arranged at the bottom of the culture unit where the culture container 3 is placed. One side of the door 2 is hinged to the box 1, and the door 2 has an observation window that passes through for each culture unit. The through observation window is sealed and shielded with a magnetic window panel, which is convenient for removing the window panel for observation.

[0042] During use, the experimenter first enters the experimental plan on the operating interface of the human-computer interaction module, including the sample type, drug type and addition amount, experimental time, sensor monitoring parameters and frequency, etc. Then, the experimental sample is placed in the culture container 3 of the sample culture module. The experimenter uses a micropipette to accurately add drugs and reagents to each culture container 3 and connects multiple parameter sensor modules. At the same time, check whether the various parameters of the environmental control module are set correctly to ensure that the experimental device is in a ready state. The vibration device is started to fully mix the sample and the drug. The environmental control module adjusts the temperature, humidity and gas composition of the culture environment according to the preset parameters to provide suitable conditions for sample culture.

[0043] The multi-parameter sensor module monitors changes in various sample parameters during drug exposure in real time and transmits the collected signals to the data acquisition and analysis module. The data acquisition card collects sensor signals at high speed. After amplification by a signal amplifier and initial processing by a microprocessor, the signals are transmitted to the data analysis software for in-depth analysis.

[0044] The human-computer interaction module displays various experimental parameters and analysis results in real time. Experimenters can view sensor data curves, sample images, and other information through the touch screen 5. Data analysis software performs statistical analysis on the collected data and generates experimental reports based on experimental requirements. Experimenters can adjust experimental parameters based on the experimental results and conduct subsequent experiments.

[0045] This specific embodiment is merely an explanation of the present invention and is not intended to limit the present invention. After reading this specification, those skilled in the art may make non-creative modifications to this embodiment as needed. However, as long as such modifications are within the scope of the claims of the present invention, they are protected by patent law.

Claims

1. A pharmacology auxiliary experimental device, characterized in that: include: Sample culture module, providing a suitable culture environment for experimental samples; The modular design includes multiple independent culture units, each of which is connected to other modules through standardized interfaces. Each culture unit is equipped with a vibration device and a culture container, as well as a high-precision micro-pipette to precisely control the amount of drugs and various reagents added. The multi-parameter sensor module is used to monitor the changes of multiple parameters during the drug action process in real time by setting multiple types of sensors in each culture unit; The data acquisition and analysis module is installed inside the sample culture module to collect the signals output by the multi-parameter sensor module and process and analyze the data; Environmental control module, with temperature control system and humidity control system in each culture unit, to provide stable environmental conditions for sample culture and sensor operation; The human-computer interaction module uses a touch screen to provide experimenters with a convenient operation interface and intuitive display of experimental results.

2. A pharmacology auxiliary experimental device according to claim 1, characterized in that: The multi-parameter sensor module includes the following types of sensors installed in each culture unit: An optical sensor employs charge-coupled device (CCD) imaging technology, coupled with a fluorescence excitation light source and a filter set, with a spatial resolution of up to 1 micron. Electrochemical sensors employ microelectrode array technology, with electrodes made of high-purity precious metals and modified at the nanometer level, resulting in a response time of less than 1 second and a detection limit of nanomolar levels. Pressure sensor, the pressure sensor is a piezoresistive sensor with a measurement range of 0-10 atmospheres, an accuracy of 0.01% FS, a built-in temperature compensation circuit, and a response frequency of 1000Hz The temperature sensor is a platinum resistance sensor with a measurement range of 0-100°C, an accuracy of ±0.01°C, a four-wire measurement method, and a response time of less than 0.5 seconds.

3. The pharmacology auxiliary experimental device according to claim 1, characterized in that: The data acquisition and analysis module includes a circuit board, a data acquisition card with a 16-bit A / D converter, a signal amplifier with a low-noise, high-gain operational amplifier, a microprocessor with a high-performance embedded processor, and modularly designed data analysis software. The data acquisition card has a sampling frequency of up to 1MHz and is equipped with USB, Ethernet, and RS485 input and output interfaces. The signal amplifier has a gain range of 1-1000 times and a built-in anti-aliasing filter. The microprocessor has a main frequency of more than 1GHz and a built-in real-time operating system. The data analysis software supports importing and exporting data in multiple formats, can be connected to Excel and MATLAB tools, and uses a graphical user interface.

4. The pharmacology auxiliary experimental device according to claim 1, characterized in that: The environmental control module includes a temperature control system using a PID control algorithm, a humidity control system combining spray humidification and condensation dehumidification, and a gas concentration control system, which can adjust the temperature, humidity and gas concentration of each culture unit; the temperature control system uses heating wires and semiconductor refrigeration chips to adjust the temperature, and the fluctuation range is controlled within ±0.1°C; the humidity control system is equipped with an ultrasonic atomizer and a semiconductor refrigeration chip, and maintains humidity stability through a high-precision humidity sensor; the gas concentration control system includes a gas flow controller, a gas mixer and an external gas cylinder for various gases; the gas flow controller of the gas concentration control system has an accuracy of ±1% FS, which can accurately control the flow of multiple gases and evenly mix them.

5. The pharmacology auxiliary experimental device according to claim 1, characterized in that: The human-computer interaction module adopts a high-resolution LCD touch screen and is equipped with a multi-function button area with an anti-glare surface. It has the functions of experimental parameter setting, experimental process monitoring, data analysis, data display, query and export.

6. The pharmacology auxiliary experimental device according to claim 1, characterized in that: The micropipette in the sample culture module is a high-precision pipette with a minimum sample volume of 1 nanoliter and a sample accuracy error controlled within ±0.5%; the vibration device uses a vibration motor, and its vibration power and intensity can be controlled and adjusted by the system; the culture container is made of biocompatible polystyrene material, which has undergone special surface treatment to promote cell adhesion and growth, has a transmittance of more than 90%, and has different volume specifications of 10 ml, 30 ml, 50 ml, 80 ml, and 100 ml.

7. A pharmacology auxiliary experiment device according to claims 1-6, characterized in that: The invention also includes a box body, the front of which is provided with a hinged door, a touch display screen and a multi-function button area are arranged on the front of the box body, a removable baffle is provided on the back of the box body, a closed vertical plate is provided near the baffle inside the box body, and an ultrasonic nebulizer, a gas mixer and a main exhaust pipe are installed between the vertical plate and the baffle; the gas mixer is provided with a main air inlet connected to an external gas cylinder; the gas mixer is provided with a plurality of air inlet pipes respectively connected to the culture container of each culture unit; the ultrasonic nebulizer is provided with a plurality of atomizing pipes connected to each air inlet pipe; the main exhaust pipe is provided with a plurality of exhaust branch pipes connected to the culture container of each culture unit, and the main exhaust pipe is provided with an exhaust port through the baffle; the inside of the box body is provided with longitudinal and transverse staggered partitions between the vertical plate and the door to separate the inside of the box body into a plurality of independent culture units; the semiconductor refrigeration plate is arranged in a ring shape at the bottom of the culture unit, the heating wire is arranged on the side wall of the culture unit, and the vibration motor is arranged at the bottom of the culture unit where the culture container is placed.

8. The pharmacology auxiliary experiment device according to claim 7, characterized in that: One side of the box door is hinged to the box body through a hinge, and the box door is provided with a through observation window corresponding to each culture unit, and the through observation window is provided with a magnetic window panel for sealing and shielding.

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