Traditional Chinese medicine composition for treating gastroesophageal reflux and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating gastroesophageal reflux and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises the following components in parts by weight: 10-30 parts of ochre, 2-8 parts of inula flower, 5-15 parts of codonopsis pilosula, 3-9 parts of scutellaria baicalensis, 10-30 parts of cuttlebone, 5-15 parts of thunberg fritillary bulb, 10-20 parts of hairyvein agrimony, 5-15 parts of fructus aurantii, 5-15 parts of mangnolia officinalis, 3-9 parts of rhizoma bletillae, 1-4 parts of fructus evodiae and 2-9 parts of coptis chinensis. The traditional Chinese medicine composition plays a role through multiple targets, can treat gastroesophageal reflux fundamentally, and avoids relapse.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating gastroesophageal reflux and application thereof. BACKGROUND

[0002] Gastroesophageal reflux (GER) is a disease that gastric contents (including gastric acid, pepsin, bile, etc.) refluxes to the esophagus, even to the oropharynx, causing discomfort symptoms and / or esophageal mucosa injury.

[0003] Modern medicine considers that its pathogenesis is mainly related to factors such as dysfunction of lower esophageal sphincter, reduced esophageal clearance, delayed gastric emptying, and weakened esophageal mucosa barrier function. If the reflux exists for a long time, it may develop into gastroesophageal reflux disease, and even cause complications such as esophagitis and Barrett's esophagus. Traditional Chinese medicine considers that the core pathogenesis is stomach qi going up, which is closely related to dysfunction of liver, spleen and stomach.

[0004] At present, the main drugs for treating gastroesophageal reflux include acid suppressants, mucosa protective agents, pro-gastrointestinal motility drugs and anti-bile reflux drugs. The above drugs achieve the purpose of relieving symptoms by reducing gastric acid secretion, forming a protective film on the esophageal mucosa, reducing the damage of gastric acid and bile, etc. However, the above drugs have a great dependence, need to be taken for a long time, and about 70% of patients will relapse after stopping taking the drugs. In addition, western medicines have large side effects, long-term use will cause osteoporosis, vitamin B12 deficiency and intestinal flora imbalance, etc., which seriously affect the work and life of patients. SUMMARY

[0005] In view of the above deficiencies in the prior art, the application provides a traditional Chinese medicine composition for treating gastroesophageal reflux and application thereof. The traditional Chinese medicine composition plays a role through multiple targets, can fundamentally treat gastroesophageal reflux, avoid recurrence, and has the advantage of small side effects.

[0006] To achieve the above object, the technical scheme adopted by the application to solve its technical problem is:

[0007] A traditional Chinese medicine composition for treating gastroesophageal reflux comprises the following components in parts by weight: 10-30 parts of ocher, 2-8 parts of xuanfuhua, 5-15 parts of dangshen, 3-9 parts of huangqin, 10-30 parts of haipiaoxie, 5-15 parts of zhebeimu, 10-20 parts of xianhecao, 5-15 parts of zhike, 5-15 parts of hupao, 3-9 parts of baiji, 1-4 parts of wuzhuyu and 2-9 parts of huanglian.

[0008] Further, the invention includes the following components in parts by weight: 15-25 parts of ochre, 3-6 parts of inula flower, 8-12 parts of codonopsis pilosula, 4-8 parts of scutellaria baicalensis, 15-25 parts of cuttlefish scaly, 8-12 parts of thunbergia thunbergii, 12-17 parts of agrimony, 8-12 parts of fructus aurantii, 8-12 parts of magnolia bark, 4-8 parts of bletilla striata, 1-3 parts of evodia rutaecarpa and 4-8 parts of coptis chinensis.

[0009] Further, the invention comprises the following components in parts by weight: 20 parts of ochre, 5 parts of inula flower, 10 parts of codonopsis pilosula, 6 parts of scutellaria baicalensis, 20 parts of cuttlefish scaly, 10 parts of thunbergia thunbergii, 15 parts of agrimony, 10 parts of fructus aurantii, 10 parts of magnolia bark, 6 parts of bletilla striata, 2 parts of evodia rutaecarpa and 6 parts of coptis chinensis.

[0010] Further, the invention comprises the following components in parts by weight: 25 parts of ochre, 3 parts of inula flower, 12 parts of codonopsis pilosula, 4 parts of scutellaria baicalensis, 25 parts of cuttlefish scaly, 8 parts of thunbergia thunbergii, 17 parts of agrimony, 8 parts of fructus aurantii, 12 parts of magnolia bark, 4 parts of bletilla striata, 3 parts of evodia rutaecarpa and 8 parts of coptis chinensis.

[0011] Further, the invention comprises the following components in parts by weight: 15 parts of ochre, 6 parts of inula flower, 8 parts of codonopsis pilosula, 8 parts of scutellaria baicalensis, 15 parts of cuttlefish scaly, 12 parts of thunbergia thunbergii, 12 parts of agrimony herb, 12 parts of fructus aurantii, 8 parts of magnolia bark, 8 parts of bletilla striata, 1 part of evodia rutaecarpa and 4 parts of coptis chinensis.

[0012] Furthermore, the Citrus aurantium is stir-fried Citrus aurantium with bran.

[0013] Application of the above-mentioned traditional Chinese medicine composition for treating gastroesophageal reflux in preparing medicine for gastroesophageal reflux.

[0014] The beneficial effects produced by the present invention are:

[0015] The ochre in the present invention is heavy and has a strong effect of settling the adverse symptoms, and is specifically used to treat the upward adverse stomach qi, and is an important medicine for lowering the adverse symptoms; the scutellaria baicalensis can eliminate phlegm and promote water circulation, lower the qi and stop belching, and help the ochre to enhance the power of lowering the adverse symptoms and resolving phlegm; the two are together the monarch medicine,

[0016] Codonopsis nourishes the spleen and stomach, supports the vital energy, and prevents excessive downward flow from damaging the vital energy, embodying the principle of "reducing while replenishing". Cuttlefish herb reduces acidity and relieves pain, is astringent and stops bleeding, and has a therapeutic effect on gastric acid reflux and esophageal burns. Fritillaria thunbergii clears heat and resolves phlegm, disperses stagnation and detoxifies, and can help Cuttlefish herb reduce acidity and prevent phlegm and heat from forming. Among them, Codonopsis strengthens the vital energy, while Cuttlefish herb and Fritillaria thunbergii reduce acidity and resolve phlegm, assisting the monarch herb in enhancing the therapeutic effect. The above are collectively referred to as ministerial herbs.

[0017] Huangqin clears heat from the stomach, helps Zhebeimu to clear heat and reduce phlegm, Xianhecao contracts and stops bleeding, prevents gastric acid reflux from causing damage to the esophageal mucosa, and Huochejuancha and Houpu regulate qi and eliminate stagnation, strengthen the descending force, help the monarch drug restore the ascending and descending of qi, Baiji contracts and stops bleeding, promotes tissue regeneration, protects the esophageal mucosa, and promotes repair of damage; Huanglian clears heat from the stomach, and Wuzhuyu soothes the liver and promotes qi, the two drugs are used together, with pungent and bitter flavors, to regulate the liver and stomach; the above-mentioned drugs are auxiliary drugs that clear heat, stop bleeding, regulate qi, promote tissue regeneration, regulate the liver and stomach, and treat symptoms and pathological products;

[0018] In the present application, multiple targets are used to play a role, ochre, xuanfuhua, haipiaoxie and zhebeimu are used to play the role of descending and acid reducing, huangqin, huanglian and wuzhuyu are used to play the role of clearing heat and soothing the liver, danshen and xianhecao are used to play the role of strengthening the spleen and supporting the healthy, preventing damage to the healthy by eliminating evil, and preventing damage to yin by reducing acid, the above-mentioned drugs complement each other, and together play the role of treating the root and the branch, and fundamentally achieve the treatment of gastroesophageal reflux. DETAILED DESCRIPTION

[0019] In order to make the purpose, technical scheme and advantages of the present application clearer, the present application will be further described in detail below in combination with embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and are not used to limit the present application, that is, the described embodiments are only a part of the embodiments of the present application, but not all the embodiments.

[0020] Therefore, the detailed description of the embodiments of the present application provided below is not intended to limit the scope of the claimed application, but only represents selected embodiments of the present application. Based on the embodiments of the present application, all other embodiments obtained by those skilled in the art without creative work are within the scope of protection of the present application.

[0021] It should be noted that the terms "first" and "second" and the like relational terms are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between the entities or operations. Moreover, the terms "include", "contain" or any other variant thereof are intended to cover non-exclusive inclusion, so that the process, method, article or device including a series of elements not only includes those elements, but also includes other elements not explicitly listed or inherent to such process, method, article or device. Without more limitations, the element defined by the statement "including a" does not exclude the presence of another identical element in the process, method, article or device including the element.

[0022] The features and properties of the present application will be further described below in combination with embodiments.

[0023] Example 1

[0024] A traditional Chinese medicine composition for treating gastroesophageal reflux comprises the following components in parts by weight: ocher 30 parts, inula 2 parts, radix codonopsitis 15 parts, radix scrophulariae 3 parts, concha arcae 30 parts, fritillariae thunbergii 5 parts, herba potentillae 20 parts, fructus aurantii 5 parts, magnoliae officinalis 15 parts, bletilla striata 3 parts, evodia 4 parts and coptis 9 parts.

[0025] Example 2

[0026] A traditional Chinese medicine composition for treating gastroesophageal reflux comprises the following components in parts by weight: ocher 10 parts, inula 8 parts, radix codonopsitis 5 parts, radix scrophulariae 9 parts, concha arcae 10 parts, fritillariae thunbergii 15 parts, herba potentillae 10 parts, fructus aurantii 15 parts, magnoliae officinalis 5 parts, bletilla striata 9 parts, evodia 1 part and coptis 2 parts.

[0027] Example 3

[0028] A traditional Chinese medicine composition for treating gastroesophageal reflux comprises the following components in parts by weight: ocher 20 parts, inula 5 parts, radix codonopsitis 10 parts, radix scrophulariae 6 parts, concha arcae 20 parts, fritillariae thunbergii 10 parts, herba potentillae 15 parts, fructus aurantii 10 parts, magnoliae officinalis 10 parts, bletilla striata 6 parts, evodia 2 parts and coptis 6 parts.

[0029] Example 4

[0030] A traditional Chinese medicine composition for treating gastroesophageal reflux comprises the following components in parts by weight: ocher 25 parts, inula 3 parts, radix codonopsitis 12 parts, radix scrophulariae 4 parts, concha arcae 25 parts, fritillariae thunbergii 8 parts, herba potentillae 17 parts, fructus aurantii 8 parts, magnoliae officinalis 12 parts, bletilla striata 4 parts, evodia 3 parts and coptis 8 parts.

[0031] Example 5

[0032] A traditional Chinese medicine composition for treating gastroesophageal reflux comprises the following components in parts by weight: ocher 15 parts, inula 6 parts, radix codonopsitis 8 parts, radix scrophulariae 8 parts, concha arcae 15 parts, fritillariae thunbergii 12 parts, herba potentillae 12 parts, fructus aurantii 12 parts, magnoliae officinalis 8 parts, bletilla striata 8 parts, evodia 1 part and coptis 4 parts.

[0033] Comparative Example 1

[0034] A traditional Chinese medicine composition for treating gastroesophageal reflux comprises the following components in parts by weight: ocher 20 parts, pinellia 5 parts, radix codonopsitis 10 parts, radix scrophulariae 6 parts, concha arcae 20 parts, trichosanthes 10 parts, herba potentillae 15 parts, pericarpium citri reticulatae 10 parts, saussurea 10 parts, bletilla striata 6 parts, evodia 2 parts and coptis 6 parts.

[0035] Comparative Example 2

[0036] A traditional Chinese medicine composition for treating gastroesophageal reflux, comprising the following components in parts by weight: ocher 20 parts, xuanfuhua 5 parts, huangqi 10 parts, huangqin 6 parts, calcined mume 20 parts, zhebeimu 10 parts, wumei 15 parts, zhike 10 parts, hupao 10 parts, baiji 6 parts, wuzhuyu 2 parts, and huanglian 6 parts.

[0037] Test Example

[0038] I. General information

[0039] 80 patients diagnosed with gastroesophageal reflux were selected, including 41 males and 39 females, aged 25-60 years, with an average age of 42.6 years.

[0040] II. Disease diagnosis criteria

[0041] Main symptoms: acid reflux (upward flow of acid water in the stomach), heartburn (burning sensation in the back of the sternum or stomach), often aggravated after meals, in a lying position or emotional fluctuations;

[0042] Secondary symptoms: bitter mouth, dry throat, irritability, constipation, or chest distention, frequent belching, depression, or postprandial abdominal distension, fatigue, loss of appetite, loose stools, or chest tightness, excessive phlegm, sticky mouth, obesity, or stomach pain, warm and pressing, but also heartburn, acid reflux, dry mouth and unwilling to drink.

[0043] Tongue and pulse: red tongue with yellow fur, or pale tongue with white or greasy fur, or thick white and greasy fur, or pale tongue with thin yellow or yellow and white fur;

[0044] Pulse: stringy pulse, weak pulse or slippery pulse.

[0045] III. Administration method

[0046] The patients diagnosed with gastroesophageal reflux were randomly divided into 3 groups, 20 patients in each group. The patients in different groups were treated with the drugs in Example 3, Comparative Example 1 and Comparative Example 2, respectively, three times a day, with a dosage equivalent to 20g of raw medicinal materials each time, for 30 consecutive days. During the treatment period, the patients should eat light and avoid spicy food.

[0047] IV. Efficacy evaluation criteria

[0048] Each symptom was scored according to the severity (mild 1 point, moderate 2 points and severe 3 points) before and after treatment, and then the total symptom score was calculated;

[0049] Symptom score reduction rate = (pre-treatment score - post-treatment score) / pre-treatment score * 100%;

[0050] Cure: main symptoms such as acid reflux and heartburn disappeared, secondary symptoms were completely relieved, tongue and pulse returned to normal, and no recurrence within 3 months.

[0051] Marked effect: main symptoms such as acid reflux and heartburn disappear (symptom score reduction ≥ 70%), secondary symptoms are relieved;

[0052] Effective: main symptoms are alleviated (symptom score reduction ≥ 30% but < 70%), secondary symptoms are partially relieved, and tongue and pulse are improved;

[0053] Ineffective: symptoms are not improved or aggravated (symptom score reduction < 30%), and tongue and pulse are not changed;

[0054] V. Therapeutic effect results

[0055]

[0056] From the results in the above table, it can be seen that the traditional Chinese medicine composition in Example 3 of the present application has good therapeutic effect on gastroesophageal reflux, and the total effective rate of treatment is as high as 100%. However, the compositions in Comparative Example 1 and Comparative Example 2 are adjusted in composition, and the results show that the therapeutic effect of the adjusted composition is decreased, only a small part of patients' symptoms are relieved to a certain extent, and most of the patients' symptoms have no obvious change. It is speculated that the complementary effect between the drugs is weakened or disappeared after the adjustment of the composition, resulting in the deterioration of the final therapeutic effect of the composition.

Claims

1. A Chinese medicine composition for treating gastroesophageal reflux, characterized in that: The invention comprises the following components in parts by weight: 10-30 parts of ochre, 2-8 parts of inula flower, 5-15 parts of codonopsis pilosula, 3-9 parts of scutellaria baicalensis, 10-30 parts of cuttlefish scaly, 5-15 parts of thunbergia thunbergii, 10-20 parts of agrimony, 5-15 parts of fructus aurantii, 5-15 parts of magnolia bark, 3-9 parts of bletilla striata, 1-4 parts of evodia rutaecarpa and 2-9 parts of coptis chinensis.

2. The Chinese medicine composition for treating gastroesophageal reflux according to claim 1, wherein The invention comprises the following components in parts by weight: 15-25 parts of ochre, 3-6 parts of inula flower, 8-12 parts of codonopsis pilosula, 4-8 parts of scutellaria baicalensis, 15-25 parts of cuttlefish scaly, 8-12 parts of thunbergia thunbergii, 12-17 parts of agrimony, 8-12 parts of fructus aurantii, 8-12 parts of magnolia bark, 4-8 parts of bletilla striata, 1-3 parts of evodia rutaecarpa and 4-8 parts of coptis chinensis.

3. The Chinese medicine composition for treating gastroesophageal reflux according to claim 1, wherein The invention comprises the following components in parts by weight: 20 parts of ochre, 5 parts of inula flower, 10 parts of codonopsis pilosula, 6 parts of scutellaria baicalensis, 20 parts of cuttlefish scaly, 10 parts of thunbergia thunbergii, 15 parts of agrimony, 10 parts of fructus aurantii, 10 parts of magnolia bark, 6 parts of bletilla striata, 2 parts of evodia rutaecarpa and 6 parts of coptis chinensis.

4. The Chinese medicine composition for treating gastroesophageal reflux according to claim 1, wherein The invention comprises the following components in parts by weight: 25 parts of ochre, 3 parts of inula flower, 12 parts of codonopsis pilosula, 4 parts of scutellaria baicalensis, 25 parts of cuttlefish scaly, 8 parts of thunbergia thunbergii, 17 parts of agrimony, 8 parts of fructus aurantii, 12 parts of magnolia bark, 4 parts of bletilla striata, 3 parts of evodia rutaecarpa and 8 parts of coptis chinensis.

5. The Chinese medicine composition for treating gastroesophageal reflux according to claim 1, wherein The invention comprises the following components in parts by weight: 15 parts of ochre, 6 parts of inula flower, 8 parts of codonopsis pilosula, 8 parts of scutellaria baicalensis, 15 parts of cuttlefish scaly, 12 parts of thunbergia thunbergii, 12 parts of agrimony herb, 12 parts of fructus aurantii, 8 parts of magnolia bark, 8 parts of bletilla striata, 1 part of evodia rutaecarpa and 4 parts of coptis chinensis.

6. The Chinese medicine composition for treating gastroesophageal reflux according to any one of claims 1 to 5, characterized in that: The fructus aurantii is fried fructus aurantii with bran.

7. Use of the traditional Chinese medicine composition for treating gastroesophageal reflux according to any one of claims 1 to 6 in the preparation of a drug for treating gastroesophageal reflux.

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