Traditional Chinese medicine compound preparation for prostate postoperative urination disorder based on double-effect synergistic effect

Abstract

The invention relates to the technical field of traditional Chinese medicine compositions, and discloses a traditional Chinese medicine compound preparation for prostate postoperative urination disorder based on a double-effect synergistic effect. The traditional Chinese medicine composition is prepared from the following components: commelina communis, cowherb seed, semen plantaginis, rhizoma phragmitis, bamboo leaves, lalang grass rhizome, herba cepbalanoplosis segeti, pyrrosia lingua, pollen typhae, rhizoma anemarrhenae, folium mori, chrysanthemum, fructus gardeniae, herba artemisiae scopariae, oldenlandia diffusa, radix cynanchi atrati, folium ilicis purpurea, dandelion and herba violae. The traditional Chinese medicine is prepared from cortex erythrinae, radix achyranthis bidentatae, herba taxilli, cortex eucommiae, radix ampelopsis, flos sophorae, cortex magnoliae officinalis, semen raphani, fructus amomi rotundus, semen coicis, poria cocos, capsella bursa-pastoris, radix astragali, the traditional Chinese medicine compound preparation for the prostate postoperative urination disorder based on the double-effect synergistic effect can effectively relieve pain; aiming at intractable cases with ineffective arterial injection, the urination pain is reduced by more than or equal to 50% within 2 hours; the component I is used for resisting inflammation, inhibiting bacteria and improving urinary tract spasm; and the component II has the effects of enhancing kidney functions, tonifying spleen, promoting diuresis and regulating nerves.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine compound preparation for postoperative urinary dysfunction of prostate based on double-effect synergistic action. BACKGROUND

[0002] In the prior art, patients after prostate surgery often have intractable urinary pain and distending pain, and the treatment effect of conventional arterial injection is limited. In the prior art, the treatment of postoperative urinary dysfunction of prostate has the following defects:

[0003] 1. Western medicine therapy (such as alpha receptor blocker) can easily cause side effects such as postural hypotension;

[0004] 2. Single-effect traditional Chinese medicine (such as Bazheng Powder) has insufficient curative effect on intractable cases;

[0005] 3. After arterial injection, 30%-40% of patients still have persistent pain (see Chinese Journal of Urology, 2020, No. 5).

[0006] At present, there is a lack of treatment scheme with multiple effects of clearing heat and removing stranguria, anti-inflammatory hemostasis, tonifying kidney and dredging collaterals and no side effects. SUMMARY

[0007] To solve the problems in the background art, the present application provides a traditional Chinese medicine compound preparation for postoperative urinary dysfunction of prostate based on double-effect synergistic action, which clears heat and removes stranguria, detoxifies and stops bleeding, and tonifies kidney and dredges collaterals to synergistically treat intractable urinary pain and distension in patients with severe prostate after surgery.

[0008] To achieve the above-mentioned purpose, the present application provides the following technical scheme: a traditional Chinese medicine compound preparation for postoperative urinary dysfunction of prostate based on double-effect synergistic action, which is composed of the following two groups of components:

[0009] Component I: heat-clearing and stranguria-removing detoxification group (for treating heat stranguria, blood stranguria, liver yang hyperactivity, dizziness, jaundice, red urine, urinary tract infection), containing 25-35g of Commelina communis, 10-20g of Ficus hispida, 15-25g of Plantago asiatica, 25-35g of Phragmites communis, 10-20g of Bambusa vulgaris, 25-35g of Imperata cylindrica, 25-35g of Asteriscus chinensis, 10-20g of Typha angustifolia, 10-20g of Anemarrhena asphodeloides, 10-20g of Morus alba, 10-20g of Chrysanthemum morifolium, 10-20g of Gardenia jasminoides, 15-25g of Artemisia capillaris, 25-35g of Sarcandra glabra, 10-20g of Polygonum aviculare, 10-20g of Taraxacum mongolicum, and 25-35g of Viola yedoensis;

[0010] Component II: kidney and spleen invigorating and dampness expelling group (for treating wind and dampness, waist and leg muscle pain, kidney deficiency and waist pain, hemorrhoid bleeding and pain, dryness and qi movement, middle jiao dampness, food accumulation and abdominal distension, defecation, spleen and stomach, food and body, forgetfulness and insomnia, diuresis and edema, qi and yin), including Haitongpi 10-20g, Niuxi 15-25g, Sangjisheng 10-20g, Duzhong 15-25g, Baixian 15-25g, Huaihua 15-25g, Houpu 15-25g, Laihu 25-35g, Doukou 15-25g, Yiyiren 25-35g, Fuling 20-30g, Jicai 30-40g, Huangqi 30-40g, Dazao 20-30g, Baishu 20-30g, Gouqi 20-30g, Tiandong 20-30g.

[0011] Further, the weight ratio of each medicinal material in component I is:

[0012] Duckweed 30g, King not stay 15g, Psyllium 20g, Phragmites 30g, Bamboo leaves 15g, White 30g, Small 25g, Stone 25g, Puhuang 15g, Zhimu 15g, Mulberry leaves 15g, Chrysanthemum 15g, Gardenia 15g, Artemisia 20g, White snake 30g, White 15g, Four seasons 30g, Dandelion 20g, Purple flower 30g.

[0013] Further, the weight ratio of each medicinal material in component II is:

[0014] Haitongpi 15g, Niuxi 20g, Sangjisheng 15g, Duzhong 20g, Baixian 20g, Huaihua 20g, Houpu 20g, Laihu 30g, Doukou 20g, Yiyiren 30g, Fuling 25g, Jicai 35g, Huangqi 35g, Dazao 25g, Baishu 25g, Gouqi 25g, Tiandong 25g.

[0015] Further, the weight ratio of component I and component II is 1:1-1.2.

[0016] Further, the preparation is water decoction, concentrated granules or pills.

[0017] The application also provides the following technical scheme: a method for preparing the traditional Chinese medicine compound preparation according to any one of claims 1-5, comprising the following steps:

[0018] (1) the medicinal materials of component I are mixed, 8-10 times the amount of water is added and decocted for 1-1.5 hours, and then filtered to obtain medicinal liquid;

[0019] (2) the medicinal materials of component II are mixed, 8-10 times the amount of water is added and decocted for 1-1.5 hours, and then filtered to obtain medicinal liquid;

[0020] (3) the medicinal liquids obtained in steps (1) and (2) are respectively concentrated to a relative density of 1.10-1.20 (60℃).

[0021] Further, it also includes:

[0022] The concentrated component I liquid medicine is divided into 6 parts, and one part is taken after breakfast every day;

[0023] The concentrated component II liquid medicine is divided into 6 parts, and one part is taken after dinner every day;

[0024] The remaining liquid medicine is stored in a refrigerator, and is heated to 40-50 DEG C when taken.

[0025] Further, it is suitable for postoperative patients of prostate who are invalid for arterial injection treatment;

[0026] The treatment standard is VAS score >=7 and residual urine volume >=100 mL.

[0027] Compared with the prior art, the beneficial effects of the present application are as follows:

[0028] 1. Efficiently relieving pain: for intractable cases invalid for arterial injection, the urination pain (VAS score) is reduced by >=50% within 3 days.

[0029] 2. Multi-target treatment:

[0030] Component I: anti-inflammatory (reducing IL-6, TNF-alpha), bacteriostatic (Escherichia coli, Staphylococcus aureus), improving urinary tract spasm;

[0031] Component II: enhancing kidney function (reducing creatinine), invigorating spleen and removing dampness (improving weak spleen and stomach), regulating nerves (relieving insomnia).

[0032] 3. Safe without side effects: 50 cases of clinical verification, no liver and kidney function abnormalities (ALT / AST, Cr are normal).

[0033] 4. Clear indication: specifically treating intractable urination disorders after prostate surgery (residual urine volume >=100 mL, VAS >=7).

[0034] The following are the effects of the traditional Chinese medicines used in the present application:

[0035] Commelina: sweet, bitter and cold; clearing heat and resolving toxins, treating wind-heat cold, diuresis, heat and stranguria, edema and oliguria.

[0036] Tetragonal stachys herb: bitter and flat; promoting blood circulation and unblocking channels, diuresis and treating stranguria, treating heat stranguria, stopping bleeding, having anti-inflammatory and anticancer effects.

[0037] Vehicle seed: sweet and cold; diuresis and treating stranguria, treating edema, dysuria, damp heat stranguria, preventing kidney stone formation, and preventing kidney stone formation.

[0038] Phragmites communis: sweet and cold; clearing heat and generating fluid, relieving restlessness, stopping vomiting, diuresis and treating heat stranguria and pain, and not permeable.

[0039] Bamboo leaves: sweet, light and cold; clear away heat and relieve restlessness, promote salivation and quench thirst, treat thirst caused by fever, and act as a diuretic to treat dribbling and painful urination.

[0040] Imperata Root: Sweet and cold; cools blood and stops bleeding, treats blood heat, hemoptysis, hematemesis, and hematuria. Clears heat and promotes urination, treating fever, thirst, damp-heat jaundice, painful stranguria caused by heat, and edema caused by nephritis.

[0041] Thistle: Bitter, sweet, and cool; cools blood and stops bleeding, treats blood heat bleeding, detoxifies, disperses blood stasis, and relieves pain, treats heat-induced pain and swelling, clears dampness and heat, and treats jaundice. Modern use is for kidney and hypertension.

[0042] Selaginella: bitter, sweet, slightly cold; diuretic and relieving stranguria, treat stranguria, clear the lungs and relieve cough, treat lung heat, cough and sputum, stop bleeding, treat blood heat, and leukocytopenia caused by chemotherapy.

[0043] Puhuang: sweet and neutral; it can dissipate blood stasis and stop bleeding, treat various internal and external bleeding diseases, stasis and pain, diuretic and urinary tract infections, treat hematuria, lower blood lipids, and treat hyperlipidemia.

[0044] Anemarrhena: Bitter, sweet, and cold. It clears heat and purges fire, treating feverish thirst and lung-heat cough. It nourishes yin and moistens dryness, treating bone steaming, hot flashes, thirst, and constipation caused by dry intestines. It has antipyretic, antibacterial, anti-inflammatory, sedative, anti-tumor, and blood sugar-lowering effects.

[0045] Mulberry leaves: bitter, sweet, and cold; dispel wind-heat, treat wind-heat colds, calm the liver and improve eyesight, treat hyperactivity of liver yang, dizziness, red and swollen eyes, clear the lungs and moisten dryness, treat autumn dry cough and lung heat hemoptysis.

[0046] Wild chrysanthemum: bitter, sweet, slightly cold; clears away heat and detoxifies, treats sores, swelling and pain, eczema, wind-heat cold, sore throat, calms the liver and purges fire, treats red and swollen eyes, dizziness.

[0047] Gardenia: bitter and cold; it can purge heat and relieve restlessness, treat restlessness caused by fever, clear away dampness and heat, treat jaundice, dark urine, painful and astringent hematuria, cool blood and stop bleeding, treat hematemesis caused by blood heat, clear away heat and detoxify, treat red and swollen eyes, fire poison sores, reduce swelling and relieve pain, and treat sprains and bruises.

[0048] Artemisia capillaris: bitter, slightly cold; clears heat and dampness, promotes bile secretion and relieves bitterness, treats jaundice, wet sores, eczema, has antipyretic, analgesic, anti-inflammatory effects, has inhibitory effects on many pathogenic cocci and fungi, can improve the body's immune function in many ways, has anti-tumor effects, and has diuretic, antiasthmatic, and caries prevention effects.

[0049] Hedyotis diffusa: Bitter, sweet, and cold. It clears heat and detoxifies, treating lung heat, wheezing, cough, sores, sore throat, intestinal carbuncle, bacterial dysentery, adnexitis, cancer, and snake bites. It also promotes diuresis and urination, treating jaundice and gonorrhea. It has antibacterial and anti-inflammatory properties. At high concentrations, it inhibits tumors and various leukemia cancer cells. It also has analgesic, sedative, and hypnotic properties, inhibits spermatogenesis, and protects the liver and promotes bile secretion.

[0050] Radix Angelicae Pubescentis: bitter, salty, cold; clearing heat and cooling blood, treating heat due to yin deficiency, diuresis and treating urinary tract infection, prostatitis, detoxification and treating sore, treating sore, swelling, and snake bite, and has the effects of antipyretic and diuresis.

[0051] Ilex asprella: bitter and cold; clearing heat and resolving toxin, treating influenza, pneumonia, sore throat, and urinary tract infection, and has the effects of anti-inflammatory and anti-tumor.

[0052] Herba Taraxaci: sweet, bitter, and cold; clearing heat and resolving toxin, relieving pain and resolving mass, treating sore, mastalgia, mumps, sore throat, red and swollen eyes, and snake bite, and has the effects of diuresis, treating urinary tract infection, and anti-tumor.

[0053] Herba Violae: bitter, pungent, and cold; clearing heat and resolving toxin, cooling blood and resolving swelling, treating sore, swelling, mastalgia, snake bite, red and swollen eyes, and sore throat, and has the effects of anti-virus, destroying endotoxin, antipyretic, anti-inflammatory, and resolving swelling.

[0054] Fructus Pittospori: bitter, pungent, and neutral; dispelling wind and dampness, unblocking collaterals and relieving pain, treating numbness due to wind and dampness, pain in waist, legs, and joints, and injury, and has the effects of anti-inflammatory, analgesic, sedative, antihypertensive, and enhancing myocardial contractility.

[0055] Radix Achyranthis Bidentatae: bitter, sweet, sour, and neutral; activating blood and resolving stasis, treating blood stasis, benefiting joints, and strengthening waist and knees, treating arthralgia, flaccidity, diuresis and treating urinary tract infection, and has the effects of anti-inflammatory, analgesic, resolving swelling, improving immune function, and delaying aging.

[0056] Lignum Sappan: bitter, sweet, and neutral; dispelling wind and dampness, tonifying liver and kidney, and strengthening bones and muscles, treating blood deficiency due to long-term arthralgia due to wind and dampness, and deficiency of liver and kidney, and has the effects of lowering blood pressure, treating habitual abortion and metrorrhagia due to deficiency of liver and kidney, and inhibiting allergic reaction.

[0057] Radix Eucommiae: sweet and warm; tonifying liver and kidney, and strengthening bones and muscles, treating kidney deficiency, arthralgia due to wind and dampness, impotence, and premature ejaculation, and has the effects of lowering blood pressure, enhancing immune function, and reducing absorption of cholesterol.

[0058] Radix Ampelopsis: bitter, pungent, cold; clearing heat and detoxifying, cooling blood and reducing swelling, treating sores, swelling, lymph node tuberculosis, hemorrhoids, leprosy, damp-heat, injury, promoting tissue regeneration and healing, treating non-healing sores, burns and scalds, having strong antibacterial and antifungal effects, strong anti-liver toxin effect and strong anti-lipid peroxidation activity.

[0059] Flos Sophorae: bitter, cold; cooling blood and stopping bleeding, treating hemorrhoids, hematochezia, hematemesis, clearing liver and fire, treating liver fire, headache, red eyes, hypertension.

[0060] Magnolia Bark: bitter, pungent, warm; drying dampness and promoting qi, treating qi stagnation and cold-dampness obstruction. Clearing the intestines and removing stagnation: treating constipation, food accumulation, abdominal distension. Promoting qi and relieving asthma: treating phlegm accumulation, qi reversal, cough and asthma, melon seed qi. Small doses of Magnolia Bark can stimulate the intestines, while large doses can inhibit them. It can also stimulate the bronchial tubes. It can prevent ulcers, significantly prevent stress-induced bleeding, and has a strong inhibitory or killing effect on bacillus and various skin fungi. It also has a significant analgesic and anti-inflammatory effect.

[0061] Radix Raphani: pungent and sweet; resolving food accumulation and reducing distension, treating food accumulation and abdominal distension, constipation, and simple intestinal obstruction. It can lower blood pressure, relieve asthma, improve urinary function, and lower cholesterol to prevent arteriosclerosis. It can contract the bladder detrusor muscle and relax the bladder sphincter, thereby improving urinary function.

[0062] Radix Alpiniae Officinarum: pungent and warm; resolving dampness and promoting qi, treating dampness in the middle jiao and qi stagnation in the spleen and stomach. It can increase gastric mucosal blood flow and serum gastrin levels, promote gastric juice secretion, enhance gastrointestinal peristalsis, stop abnormal fermentation in the intestines, remove gas accumulation in the stomach and intestines, and has an aromatic and stomach-strengthening effect. It can also stop vomiting. It has an inhibitory effect on Shigella dysenteriae.

[0063] Radix Alpiniae Officinarum: pungent and warm; resolving dampness and promoting qi, treating dampness in the middle jiao and qi stagnation in the spleen and stomach. It can increase gastric mucosal blood flow and serum gastrin levels, promote gastric juice secretion, enhance gastrointestinal peristalsis, stop abnormal fermentation in the intestines, remove gas accumulation in the stomach and intestines, and has an aromatic and stomach-strengthening effect. It can also stop vomiting. It has an inhibitory effect on Shigella dysenteriae.

[0064] Radix Alpiniae Officinarum: pungent and warm; resolving dampness and promoting qi, treating dampness in the middle jiao and qi stagnation in the spleen and stomach. It can increase gastric mucosal blood flow and serum gastrin levels, promote gastric juice secretion, enhance gastrointestinal peristalsis, stop abnormal fermentation in the intestines, remove gas accumulation in the stomach and intestines, and has an aromatic and stomach-strengthening effect. It can also stop vomiting. It has an inhibitory effect on Shigella dysenteriae.

[0065] Radix Alpiniae Officinarum: pungent and warm; resolving dampness and promoting qi, treating dampness in the middle jiao and qi stagnation in the spleen and stomach. It can increase gastric mucosal blood flow and serum gastrin levels, promote gastric juice secretion, enhance gastrointestinal peristalsis, stop abnormal fermentation in the intestines, remove gas accumulation in the stomach and intestines, and has an aromatic and stomach-strengthening effect. It can also stop vomiting. It has an inhibitory effect on Shigella dysenteriae.

[0066] Radix Astragali: sweet, slightly warm. Tonifying Qi and raising Yang, treating deficiency of spleen and lung, deficiency of middle-Jiao. Stopping sweating, treating spontaneous sweating due to deficiency of Qi. Diuresis and eliminating edema, treating chronic nephritis proteinuria. Promoting metabolism, anti-fatigue, stimulating respiration, diuresis, eliminating urinary protein, promoting hematopoiesis, enhancing immune function, anti-virus, anti-bacteria, anti-aging, anti-tumor, anti-radiation, anti-inflammatory, protecting liver.

[0067] Fructus Jujubae: sweet, warm. Tonifying Qi and invigorating the spleen, treating deficiency of the spleen and poor appetite. Nourishing blood and tranquilizing the mind, treating blood deficiency and insomnia, blood deficiency and skin itching. Softening the nature of drugs, increasing appetite, correcting gastrointestinal damage, protecting the liver, inhibiting cancer cell proliferation, and anti-mutation. It also has the effects of anti-allergy, sedation, hypnotic, inhibition of cancer cell proliferation, anti-inflammatory, and cough and sputum.

[0068] Rhizoma Atractylodis Macrocephalae: bitter, sweet, warm. Benefiting Qi and invigorating the spleen, treating deficiency of the spleen and poor appetite. Drying dampness and promoting diuresis, treating edema caused by dampness and spleen deficiency. Stopping sweating, treating spontaneous sweating due to deficiency of Qi. Tonifying Qi and stabilizing the fetus, treating deficiency of Qi and unstable fetus. Promoting protein synthesis in the small intestine, promoting cellular immune function, increasing white blood cells, protecting the liver, promoting diuresis, reducing blood sugar, anti-bacterial, anti-tumor, anti-mutagenic, and delaying renal failure.

[0069] Fructus Lycii: sweet and flat. Nourishing liver and kidney, benefiting essence and eyesight, treating deficiency of liver and kidney, impotence and spermatorrhea, infertility, dizziness, blurred vision, dry eyes, and diabetes. Modernly used for the treatment of chronic atrophic gastritis and chronic hepatitis. Contains betaine, polysaccharides, crude fat, crude protein, vitamin B2, carotene, vitamin C, and calcium, phosphorus, zinc, iron, etc. It can regulate cellular immunity and enhance the phagocytic ability of macrophages. It can delay aging and reduce cholesterol. It can promote hematopoietic function, reduce blood sugar, anti-tumor, protect the liver, and reduce blood pressure.

[0070] Radix Asparagi: sweet, bitter, cold. Nourishing Yin and generating fluid, treating heat disease, Yin deficiency, internal heat, dryness-evil, constipation. Clearing lung and reducing fire, treating dryness-evil of lung and stomach, cough, thirst, diabetes, pulmonary tuberculosis, etc. It can inhibit tumor cell proliferation and has obvious anti-cell mutation effect. It can promote antibody production and prolong antibody survival time. It has the effects of relieving cough and reducing sputum. DETAILED DESCRIPTION

[0071] The technical solutions in the embodiments of the present application will be clearly and completely described below in combination with the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, not all. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor are within the scope of protection of the present application.

[0072] Embodiment one

[0073] The application provides a technical scheme: a traditional Chinese medicine compound preparation for postoperative dysuria of prostate based on double-effect synergism

[0074] Component I is used for treating heat stranguria, blood stranguria, liver yang hyperactivity, dizziness, jaundice, red urine, and urinary tract infection.

[0075] The weight ratio of the medicinal materials in component I is as follows:

[0076] Herba commelinae 30g, fumitory 15g, psyllium 20g, reed root 30g, bamboo leaf 15g, imperata cylindrical rhizome 30g, small thistle 25g, pyrrosia 25g, pollen typhae 15g, anemarrhena 15g, mulberry leaf 15g, chrysanthemum 15g, gardenia 15g, capillary giant knotweed 20g, oldenlandia diffusa 30g, halenia 15g, evergreen 30g, dandelion 20g, and purple flowered sedum 30g are used.

[0077] Component II is used for treating wind-dampness, dredging collaterals and relieving pain, wind-dampness numbness, waist and leg muscle pain, joint benefit, strengthening waist and knees, long-term arthralgia, long-term kidney deficiency, hemorrhoids, dryness and dampness, dampness in the middle jiao, food accumulation, defecation, and improvement of urination function; treating dampness and spleen, spleen and stomach weakness, food less and body tired, and improving sleep, diuresis, tonifying qi, and tonifying yin.

[0078] The weight ratio of the medicinal materials in component II is as follows:

[0079] Cortex syzygii aromatici 15g, radix astragali 20g, lindera 15g, eucommia 20g, radix ampelopsis 20g, sophora flower 20g, magnolia officinalis 20g, raphanus sativus 30g, amomum 20g, coix seed 30g, poria 25g, brassica rapa 35g, radix astragali 35g, 25 dates, white atractylodes 25g, medlar 25g, radix oppositifolii 25g, and radix ophiopogonis 25g are used.

[0080] The above two doses of medicinal materials are each divided into 6 times, and the component I is taken after breakfast every day, and the component II is taken after dinner every day, and three doses are taken as a course of treatment.

[0081] A male patient, 68 years old, is treated with the application after 7 days of prostate cancer surgery, and arterial injection is invalid.

[0082] In the first course of treatment, the VAS score of urination pain is reduced from 8.2 to 4.5.

[0083] In the third course of treatment, the residual urine volume is reduced from 150mL to 30mL (verified by ultrasound).

[0084] Example two

[0085] The application provides a technical scheme: a double-effect synergistic post-prostatectomy urinary dysfunction traditional Chinese medicine compound preparation, the formula used in the application is compared with the Bazhengsan group and the western medicine control group, and the results are as follows:

[0086] In summary, the efficiency of the group of the application is improved by 26.8% (89.2% vs. 62.4%) compared with the single-effect Bazhengsan group;

[0087] Fast relief of symptoms: the VAS pain score of the refractory patients is reduced by more than 50% within 3 days, which is better than that of the western medicine control group (p<0.05).

[0088] The application realizes the following for the first time through the synergistic combination of the two components: multi-target regulation: acting on three pathological links of inflammatory factors (IL-6), bladder detrusor spasm and kidney deficiency and blood stasis at the same time; attenuation and synergistic effect: reducing liver toxicity through the specific proportion of Yinchen and Niuxi.

[0089] Example three

[0090] The application provides a technical scheme: a double-effect synergistic post-prostatectomy urinary dysfunction traditional Chinese medicine compound preparation, component one (heat-clearing and uricant, detoxifying and hemostatic): Commelina communis L.-Vaccaria pyramidata (30:15) can significantly reduce urinary tract smooth muscle spasm (p<0.01,); Wufu Sha Shexie- Sophora japonica (30:20) synergistically inhibits Staphylococcus aureus and Escherichia coli (MIC≤0.5 mg / mL).

[0091] Component two (kidney-tonifying and meridian-activating): Niuxi-Milkvetch (20:15) promotes tissue repair by activating the TGF-β1 pathway.

[0092] Through proportion optimization of the two components, the clinical pain points of refractory post-prostatectomy urinary dysfunction are solved, and the three breakthroughs of rapid effect, safety and precision are achieved, and the treatment blank of patients ineffective for arterial injection is filled.

[0093] Although the embodiments of the application have been shown and described, it can be understood by those of ordinary skill in the art that various changes, modifications, replacements and variations can be made to the embodiments without departing from the principles and spirits of the application, and the scope of the application is defined by the appended claims and their equivalents.

Claims

1. A Chinese herbal compound preparation for urinary dysfunction after prostate surgery based on dual-effect synergistic effects, comprising 36 Chinese medicinal materials, characterized in that It consists of the following two groups of components: Component I: Heat-clearing, stranguria-draining and detoxifying group (treats stranguria caused by heat, stranguria caused by blood, hyperactivity of liver yang, dizziness, jaundice and dark urine, urinary tract infection), including Commelina communis 25-35g, Vaccaria segetalis 10-20g, Plantago seed 15-25g, Phragmites australis 25-35g, Bamboo leaf 10-20g, Imperata cylindrica 25-35g, Thistle 25-35g, Pyrola 25-35g, Pollen cattail 10-20g, Anemarrhena 10-20g, Mulberry leaf 10-20g, Chrysanthemum 10-20g, Gardenia 10-20g, Artemisia capillaris 15-25g, Hedyotis diffusa 25-35g, White violet 10-20g, Evergreen 25-35g, Taraxacum mongolicum 10-20g, Viola yedoensis 25-35g; Component II: Kidney-tonifying, spleen-strengthening and dampness-removing group (treats wind-removing and dampness-removing, pain in waist and leg muscles and bones, chronic pain in waist and leg due to kidney deficiency, hemorrhoids and bleeding pain, dampness-clearing and qi-promoting, dampness blocking the middle jiao, abdominal distension due to food accumulation, laxative, dampness-clearing and spleen-strengthening, loss of appetite and fatigue, forgetfulness and insomnia, diuresis and swelling-reducing, qi-tonifying and yin-tonifying), contains 10-20g of Pittosporum tobira bark, 15-25g of Achyranthes bidentata, 10-20g of Mulberry parasite, 15-25g of Eucommia ulmoides g, white ampel 15-25g, Sophora japonica 15-25g, Magnolia officinalis 15-25g, radish seed 25-35g, cardamom 15-25g, coix seed 25-35g, Poria 20-30g, shepherd's purse 30-40g, astragalus 30-40g, jujube 20-30 pieces, Atractylodes macrocephala 20-30g, wolfberry 20-30g, asparagus 20-30g.

2. The Chinese medicinal compound preparation according to claim 1, characterized in that The weight ratio of each medicinal material in the component I is: Commelina 30g, Vaccaria segetalis 15g, Plantago seed 20g, Phragmites australis 30g, Bamboo leaf 15g, Imperata root 30g, Thistle 25g, Pyrola 25g, Pollen Typhae 15g, Anemarrhena 15g, Mulberry leaf 15g, Chrysanthemum 15g, Gardenia 15g, Artemisia capillaris 20g, Hedyotis diffusa 30g, White mulberry 15g, Evergreen 30g, Taraxacum mongolicum 20g, Viola yedoensis 30g.

3. The Chinese medicinal compound preparation according to claim 1, characterized in that The weight ratio of each medicinal material in the component II is: 15g of Pittosporum tobira bark, 20g of Achyranthes bidentata, 15g of Viscum album, 20g of Eucommia ulmoides, 20g of Bletilla striata, 20g of Sophora japonica flower, 20g of Magnolia officinalis, 30g of Radish seed, 20g of Cardamom, 30g of Coix seed, 25g of Poria cocos, 35g of Shepherd's purse, 35g of Astragalus membranaceus, 25 jujubes, 25g of Atractylodes macrocephala, 25g of Lycium barbarum, and 25g of Asparagus cochinchinensis.

4. The Chinese medicinal compound preparation according to any one of claims 1 to 3, characterized in that The weight ratio of component I to component II is 1:1-1.

2.

5. The Chinese medicinal compound preparation according to any one of claims 1 to 4, characterized in that The preparation is in the form of water decoction, concentrated granules or pills.

6. A method for preparing the Chinese medicinal compound preparation according to any one of claims 1 to 5, characterized in that The following steps are involved: (1) Mix the medicinal materials of component I, add 8-10 times the amount of water, and boil for 1-1.5 hours, then filter to obtain the medicinal solution; (2) Mix the medicinal materials of component II, add 8-10 times the amount of water, and boil for 1-1.5 hours, then filter to obtain the medicinal solution; (3) Concentrating the medicinal solutions obtained in step (1) and step (2) to relative densities of 1.10-1.20 (60° C.) respectively.

7. The preparation method according to claim 6, characterized in that Also includes: Divide the concentrated component I solution into 6 portions and take 1 portion every day after breakfast; Divide the concentrated component II solution into 6 portions and take 1 portion after dinner every day; The remaining liquid medicine should be refrigerated and heated to 40-50℃ before taking.

8. The use according to any one of claims 1 to 7, characterized in that: Suitable for patients after prostate surgery who are ineffective with arterial injection therapy; Treatment criteria were a VAS score ≥7 and residual urine volume ≥100 mL.

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