Compound lotion suitable for dissolving traditional Chinese medicines as well as preparation method and application of compound lotion

Abstract

The invention provides a compound lotion suitable for dissolving traditional Chinese medicines as well as a preparation method and application thereof, and relates to the technical field of daily chemical products. The compound washing agent is composed of a specific content of a surfactant system, a nonionic solubilizer and a cationic conditioner. Wherein the mass ratio of the cocamidopropyl betaine to the sodium laureth sulfate to the sodium lauroyl sarcosine is (2.0 to 2.5) to (8.0 to 9.0) to (2.8 to 3.2). According to the compound lotion obtained by synergistically compounding the surfactant system, the nonionic solubilizer and the cationic conditioner, on one hand, the compound lotion can be independently applied to effectively relieve discomfort such as scalp greasiness, itching and desquamation; on the other hand, the compound lotion has better compatibility and solubility for the traditional Chinese medicine particles, and on the premise of high drug loading capacity of the traditional Chinese medicine particles, the shampoo is stable in character and good in washing feeling, and the preparation requirements of the traditional Chinese medicine particle shampoo can be fully met.

Description

Technical Field

[0001] This invention relates to the field of daily chemical product technology, and in particular to a compound detergent suitable for dissolving traditional Chinese medicine, its preparation method, and its application. Background Technology

[0002] The scalp is part of the skin. Although its structure is not significantly different from the skin on other parts of the face, the scalp has a high density of hair follicles, vigorous sebum secretion, and a large number of sweat glands. The secretion of shed keratinocytes and lipids from sebum often causes various discomforts, such as oily scalp, itching and dandruff, scalp bumps, greasy and unclean hair, and flat and lacking volume.

[0003] There are many hair care products on the market, but relatively few specifically target the scalp for oil control and dandruff suppression. Most products focus on a single oil-control function, such as adding alcohol or aluminum salts to tighten pores, adding kaolin or starch to absorb sebum, or adding surfactants to dissolve oil. However, these products have limited ability to balance the scalp's microecology and repair the keratin barrier, and users may still experience discomfort such as oily scalp, itching, and inflammation after use.

[0004] Furthermore, traditional Chinese medicine classics record numerous formulas with effects such as preventing hair loss, promoting hair growth, and darkening hair (e.g., "He Shou Wu Tang" in *Compendium of Materia Medica*, "Fu Ling Sheng Fa Gao" in *Secret Essentials from the Outer Terrace*), the effectiveness of which has been confirmed by modern research. However, the application of traditional Chinese medicine in hair care faces the following technical bottlenecks: 1. Poor solubility: Herbal granules (such as extracts of Polygonatum sibiricum and Platycladus orientalis leaves) contain polysaccharides and tannins, which are prone to precipitation or uneven dissolution in water or conventional compound shampoos, resulting in low utilization of active ingredients. 2. Poor formulation compatibility: Existing shampoo product bases (such as SLES / SLS systems) easily react with herbal ingredients, reducing efficacy or causing flocculation. 3. Unpleasant washing experience: After adding herbal granules, products are prone to stickiness and difficulty rinsing, affecting the user experience.

[0005] Therefore, it is both necessary and urgent to research and develop a compound shampoo that can effectively relieve discomfort such as oily scalp, itching and dandruff, has good solubility and compatibility with traditional Chinese medicine granules, and provides a better washing experience.

[0006] In view of this, the present invention is hereby proposed. Summary of the Invention

[0007] The primary objective of this invention is to provide a compound shampoo, which, through the synergistic combination of a surfactant system, a nonionic solubilizer, and a cationic conditioning agent, can effectively alleviate discomfort such as oily scalp, itching, and dandruff when used alone. Furthermore, this compound shampoo exhibits excellent compatibility and solubility with traditional Chinese medicine granules. Under the premise of high drug loading of the granules, the shampoo remains stable and provides a pleasant washing experience, thus fully meeting the preparation requirements for shampoos containing traditional Chinese medicine granules.

[0008] The second objective of this invention is to provide a method for preparing a compound detergent.

[0009] A third objective of this invention is to provide an application of a compound detergent.

[0010] In order to achieve the above-mentioned purpose of the present invention, the following technical solutions are adopted: This invention provides a compound detergent suitable for dissolving traditional Chinese medicine, the compound detergent comprising: (a) A surfactant system comprising 12-15% of the total mass of the compound detergent, wherein the surfactant system comprises: cocamidopropyl betaine, sodium lauryl ether sulfate and sodium lauroyl sarcosinate; The mass ratio of cocamidopropyl betaine, sodium lauryl ether sulfate, and sodium lauroyl sarcosinate is 2.0~2.5:8.0~9.0:2.8~3.2.

[0011] (b) 0.3-0.7% of a nonionic solubilizer relative to the total mass of the compound detergent; (c) 0.2 to 0.4% of the cationic conditioner polyquaternium salt-10 relative to the total mass of the compound detergent.

[0012] Furthermore, the nonionic solubilizer includes at least one of PEG-7 glyceryl cocoate, PEG-40 hydrogenated castor oil, and PPG-26-butanol polyether, preferably PEG-40 hydrogenated castor oil.

[0013] Furthermore, the compound detergent also includes a pH adjuster, wherein the pH adjuster is citric acid.

[0014] Furthermore, the pH value of the compound detergent is 5.5~6.5.

[0015] Furthermore, the compound lotion also includes one or a combination of two of the following: Curcuma longa extract and Curcuma zedoaria extract.

[0016] Furthermore, by mass fraction, the compound detergent comprises the following components: The ingredients are: cocamidopropyl betaine 1.9-2.3%, sodium lauryl ether sulfate 8.0-8.8%, sodium lauroyl sarcosinate 2.8-3.2%, nonionic solubilizer 0.3-0.7%, cationic conditioner 0.2-0.4%, pH adjuster 0.12-0.18%, Curcuma longa extract and / or Curcuma zedoaria extract 0.04-0.06%, with the balance being water.

[0017] Furthermore, by mass fraction, the compound detergent comprises the following components: The ingredients are: 2.1% cocamidopropyl betaine, 8.4% sodium lauryl ether sulfate, 3.0% sodium lauroyl sarcosinate, 0.5% nonionic solubilizer, 0.3% cationic conditioner, 0.155% pH adjuster, 0.05% Curcuma longa extract and / or Curcuma zedoaria extract, with the balance being water.

[0018] The present invention provides a method for preparing the above-mentioned compound detergent, the preparation method comprising: S1: Cocamidopropyl betaine, sodium lauryl ether sulfate, and sodium lauroyl sarcosinate were added to water in sequence and homogenized to obtain solution A; S2: Add nonionic solubilizer, cationic conditioner, pH adjuster and oil control component to solution A and mix well to obtain compound detergent.

[0019] Furthermore, in step S1, the homogenization temperature is 85-90℃ and the time is 1-30 min; And / or, the mixing temperature in step S2 is 85-40℃, and the time is 1-30 min.

[0020] The application of the above-mentioned compound detergent provided by the present invention in the preparation of traditional Chinese medicine granule shampoo.

[0021] Compared with the prior art, the beneficial effects of the present invention are as follows: The compound shampoo provided by this invention comprises a surfactant system, a nonionic solubilizer, and a cationic conditioning agent in specific amounts; wherein the mass ratio of cocamidopropyl betaine, sodium lauryl ether sulfate, and sodium lauroyl sarcosinate is 2.0~2.5:8.0~9.0:2.8~3.2. This compound shampoo, obtained through the synergistic compounding of the above-mentioned surfactant system, nonionic solubilizer, and cationic conditioning agent, effectively alleviates discomfort such as oily scalp, itching, and dandruff when used alone. Furthermore, it exhibits good compatibility and solubility with traditional Chinese medicine granules, ensuring stable shampoo properties and a pleasant washing experience even with high drug loading of the granules, thus fully meeting the preparation requirements for shampoos containing traditional Chinese medicine granules.

[0022] The present invention provides a method for preparing a compound detergent. The method involves first adding cocamidopropyl betaine, sodium lauryl ether sulfate, and sodium lauroyl sarcosinate sequentially to water and homogenizing them to obtain solution A. Subsequently, a nonionic solubilizer, a cationic conditioning agent, a pH adjuster, and an oil-controlling component are added to solution A and mixed thoroughly to obtain the compound detergent. The above preparation method has the advantages of simple processing and ease of operation.

[0023] The compound shampoo provided by this invention can be widely used in the preparation of traditional Chinese medicine granule shampoos. Attached Figure Description

[0024] To more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0025] Figure 1 This is a comparative graph showing the results of skin oil content after use in Example 1 of Experiment 2 of the present invention; Figure 2 This is a comparison chart of the skin desquamation index results after use in Example 1 of the present invention, provided in Experimental Example 2 of the present invention; Figure 3 This is a comparison chart of the skin scaling index results after use in Example 1 provided in Experimental Example 2 of the present invention; Figure 4 The attached figure shows the stability of the traditional Chinese medicine granules of the Shuangbai external wash prepared using the compound wash solution of Example 1, which is provided in Experimental Example 3 of the present invention. Detailed Implementation

[0026] The technical solution of the present invention will be clearly and completely described below with reference to the embodiments. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0027] According to one aspect of the present invention, a compound detergent suitable for dissolving traditional Chinese medicine, the compound detergent comprising: (a) A surfactant system comprising 12-15% of the total mass of the compound detergent, wherein the surfactant system comprises: cocamidopropyl betaine, sodium lauryl ether sulfate and sodium lauroyl sarcosinate; The mass ratio of cocamidopropyl betaine, sodium lauryl ether sulfate, and sodium lauroyl sarcosinate is 2.0~2.5:8.0~9.0:2.8~3.2.

[0028] (b) 0.3-0.7% of a nonionic solubilizer relative to the total mass of the compound detergent; (c) 0.2 to 0.4% of the cationic conditioner polyquaternium salt-10 relative to the total mass of the compound detergent.

[0029] The compound shampoo provided by this invention comprises a surfactant system, a nonionic solubilizer, and a cationic conditioning agent in specific amounts; wherein the mass ratio of cocamidopropyl betaine, sodium lauryl ether sulfate, and sodium lauroyl sarcosinate is 2.0~2.5:8.0~9.0:2.8~3.2. This compound shampoo, obtained through the synergistic compounding of the above-mentioned surfactant system, nonionic solubilizer, and cationic conditioning agent, effectively alleviates discomfort such as oily scalp, itching, and dandruff when used alone. Furthermore, it exhibits good compatibility and solubility with traditional Chinese medicine granules, ensuring stable shampoo properties and a pleasant washing experience even with high drug loading of the granules, thus fully meeting the preparation requirements for shampoos containing traditional Chinese medicine granules.

[0030] In a preferred embodiment of the present invention, the nonionic solubilizer includes at least one of PEG-7 glyceryl cocoate, PEG-40 hydrogenated castor oil, and PPG-26-butanol polyether, preferably PEG-40 hydrogenated castor oil.

[0031] In a preferred embodiment of the present invention, the compound detergent further includes a pH adjuster, wherein the pH adjuster is citric acid.

[0032] In a preferred embodiment of the present invention, the pH value of the compound detergent is 5.5 to 6.5.

[0033] In a preferred embodiment of the present invention, the compound lotion further includes one or a combination of two of Curcuma longa extract and Curcuma zedoaria extract.

[0034] As a preferred embodiment, the addition of the above-mentioned Curcuma longa extract and Curcuma zedoaria extract is beneficial to improving the oil control effect of the compound lotion of this application.

[0035] Preferably, the extracts of Curcuma longa and Curcuma zedoaria in this application are both purchased from Shanghai Ruimu Chemical Technology Co., Ltd.

[0036] In a preferred embodiment of the present invention, the compound detergent comprises, by mass fraction, the following components: 1.9-2.3% cocamidopropyl betaine, 8.0-8.8% sodium lauryl ether sulfate, 2.8-3.2% sodium lauroyl sarcosinate, 0.3-0.7% nonionic solubilizer, 0.2-0.4% cationic conditioner, 0.12-0.18% pH adjuster, 0.04-0.06% Curcuma longa extract and / or Curcuma zedoaria extract, with the balance being water.

[0037] The proportion of cocamidopropyl betaine can be, but is not limited to, 1.9%, 2.0%, 2.1%, 2.2%, or 2.3%, or any proportion between 1.9% and 2.3%; the proportion of sodium lauryl ether sulfate can be, but is not limited to, 8.0%, 8.1%, 8.2%, 8.3%, 8.4%, 8.5%, 8.6%, 8.7%, or 8.8%, or any proportion between 8.0% and 8.8%; the proportion of sodium lauroyl sarcosinate can be, but is not limited to, 2.8%, 2.9%, 3.0%, 3.1%, or 3.2%, or any proportion between 2.8% and 3.2%; and the proportion of nonionic solubilizer can be, but is not limited to, 0.3%, 0.4%, 0.5%, 0.6%, or any proportion between 0.6% and 0.4%. The percentage can be 0.3% or 0.7%, or any percentage between 0.3% and 0.7%; wherein, the percentage of the cationic conditioner can be, but is not limited to, 0.2%, 0.3%, or 0.4%, or any percentage between 0.2% and 0.4%; wherein, the percentage of the pH adjuster can be, but is not limited to, 0.12%, 0.13%, 0.14%, 0.15%, 0.16%, 0.17%, or 0.18%, or any percentage between 0.12% and 0.18%; the percentage of the Curcuma longa extract and / or Curcuma zedoaria extract can be, but is not limited to, 0.04%, 0.05%, or 0.06%, or any percentage between 0.04% and 0.06%.

[0038] In a preferred embodiment of the present invention, the compound detergent comprises, by mass fraction, the following components: 2.1% cocamidopropyl betaine, 8.4% sodium lauryl ether sulfate, 3.0% sodium lauroyl sarcosinate, 0.5% nonionic solubilizer, 0.3% cationic conditioner, 0.155% pH adjuster, and 0.05% Curcuma longa extract and Curcuma zedoaria extract (of which Curcuma longa extract is 0.025% and Curcuma zedoaria extract is 0.025%), with the balance being water.

[0039] According to one aspect of the present invention, a method for preparing the above-mentioned compound detergent, the method comprising: S1: Cocamidopropyl betaine, sodium lauryl ether sulfate, and sodium lauroyl sarcosinate were added to water in sequence and homogenized to obtain solution A; S2: Add nonionic solubilizer, cationic conditioner, pH adjuster and oil control component to solution A and mix well to obtain compound detergent.

[0040] The present invention provides a method for preparing a compound detergent. The method involves first adding cocamidopropyl betaine, sodium lauryl ether sulfate, and sodium lauroyl sarcosinate sequentially to water and homogenizing them to obtain solution A. Subsequently, a nonionic solubilizer, a cationic conditioning agent, a pH adjuster, and an oil-controlling component are added to solution A and mixed thoroughly to obtain the compound detergent. The above preparation method has the advantages of simple processing and ease of operation.

[0041] In a preferred embodiment of the present invention, the homogenization temperature in step S1 is 85-90°C and the time is 1-30 min; In a preferred embodiment of the present invention, the mixing temperature in step S2 is 85-40°C and the time is 1-30 min.

[0042] According to one aspect of the present invention, the above-mentioned compound detergent is used in the preparation of traditional Chinese medicine granule shampoo.

[0043] The compound shampoo provided by this invention can be widely used in the preparation of traditional Chinese medicine granule shampoos. Specifically, it is manifested in: 1. Highly Soluble Carrier System: This application utilizes a surfactant system obtained by compounding cocamidopropyl betaine, sodium lauryl ether sulfate and sodium lauroyl sarcosinate in a specific ratio, which, in synergy with a nonionic solubilizer, has been verified to effectively enhance the solubility of traditional Chinese medicine granules in compound detergents, thereby forming a highly soluble carrier system for traditional Chinese medicine granules.

[0044] 2. Optimized washing feel design: The surfactant system of this application, by compounding with a specific amount of nonionic solubilizer and cationic conditioner system, can balance the astringent feeling of Chinese medicine granules and achieve a smooth and easy-to-rinse skin feel.

[0045] 3. Stability assurance: Based on the above-mentioned highly soluble carrier system, this application also effectively prevents the oxidation or precipitation of the Chinese medicine granule components by using citric acid, which has a chelating effect, to adjust the pH buffer system of this application (pH 5.5-6.5).

[0046] Therefore, compared with the prior art, this invention has for the first time achieved efficient dissolution of Chinese herbal medicine granules and compatibility of compound lotions in terms of washing feel, providing an industrial solution for the modern application of traditional Chinese medicine prescriptions.

[0047] The technical solution of the present invention will be further described below with reference to the embodiments.

[0048] It should be noted that this application uses water, expressed as "balance," as a necessary component to overcome the problem that the percentage range of each component in the compound detergent is less than 100%.

[0049] Example 1 A compound detergent, by mass fraction, comprises the following components: The ingredients are: 2.1% cocamidopropyl betaine, 8.4% sodium lauryl ether sulfate, 3% sodium lauroyl sarcosinate, 0.5% PEG-40 hydrogenated castor oil, 0.3% polyquaternium-10, 0.155% citric acid, 0.025% Curcuma longa extract, 0.025% Curcuma zedoaria extract, and the balance being water.

[0050] The pH value of the compound detergent is 5.5~6.5.

[0051] The preparation method of the compound detergent includes: (1) Cocamidopropyl betaine, sodium lauryl ether sulfate and sodium lauroyl sarcosinate were added to water and homogenized to obtain solution A. The homogenization temperature in step S1 is 85-90℃ and the time is 1-30 min. (2) Stir and cool to 80-85℃, add PEG-40 hydrogenated castor oil and stir evenly; stir and cool to 60-65℃, add polyquaternium-10 and turmeric extract and turmeric extract and stir evenly; stir and cool to 35-40℃, add citric acid and stir evenly, adjust pH to 5.5-6.5 to obtain compound detergent.

[0052] Examples 2-4 A compound detergent, by mass fraction, comprises the following components, as detailed in Table 1.

[0053] Table 1:

[0054] Note: "-" in the table above indicates the same as in Example 1.

[0055] The preparation method of the compound detergent is as described in Example 1.

[0056] Example 5 The difference between this embodiment and Embodiment 1 is that the amount of citric acid added is adjusted so that the pH value of the compound detergent is 7.0~7.5, and the rest is the same as in Embodiment 1.

[0057] Example 6 The difference between this embodiment and Embodiment 1 is that the amount of citric acid added is adjusted so that the pH value of the compound detergent is 4.5~5.0, and the rest is the same as in Embodiment 1.

[0058] Comparative Examples 1-7 A compound detergent, by mass fraction, comprises the following components, as detailed in Table 2.

[0059] Table 2:

[0060] Note: "-" in the table above indicates the same as in Example 1.

[0061] The preparation method of the compound detergent is as described in Example 1.

[0062] Comparative Examples 8-10 A compound detergent, by mass fraction, comprises the following components, as detailed in Table 3.

[0063] Table 3:

[0064] Note: "-" in the table above indicates the same as in Example 1.

[0065] The preparation method of the compound detergent is as described in Example 1.

[0066] Comparative Example 11 The difference between this comparative example and Example 1 is that polyquaternium-10 is replaced with an equal amount of polyquaternium-7, and the rest is the same as in Example 1.

[0067] Comparative Example 12 The difference between this comparative example and Example 1 is that polyquaternium-10 is replaced with an equal amount of behenyltrimethylammonium chloride, and the rest is the same as in Example 1.

[0068] Comparative Example 13 The difference between this comparative example and Example 1 is that polyquaternium-10 is replaced with an equal amount of guar hydroxypropyltrimethylammonium chloride, and the rest is the same as in Example 1.

[0069] It should be noted that the data processing methods for the following experimental examples in this application are as follows: The experimental data were statistically analyzed using SPSS 26.0 software. Descriptive statistics were performed on the measured values ​​and baseline values ​​at different time points, including mean, standard error, maximum value, and minimum value. In addition, subject self-assessment was conducted, using the percentage of participants who agreed with the assessment. Using SPSS analysis software, the comparison of measured values ​​and baseline values ​​at different time points was first performed using a normality test. If the data met the normality requirement (P > 0.05), a paired-samples t-test was used; otherwise, a Wilcoxon signed-rank test was used. All the above statistical analyses were two-tailed tests with a significance level of α = 0.05. The rate of change before and after product use = (data after N days of use - data before use) / data before use * 100%.

[0070] Experimental Example 1 To further demonstrate the effectiveness of Examples 1-6 and Comparative Examples 1-13, subjects with oily scalps, itchy scalp, and severe dandruff were selected for shampoo testing. Based on daily usage habits, 1-2 pumps (approximately 3-5 mL) were used; short hair was washed for about 5 minutes, and long hair for no more than 10 minutes. Ten participants were blind-selected for each product group, and the test results are detailed in Tables 4-9.

[0071] Table 4: Results of skin oil content detection in Examples 1-6 (sample size = 10)

[0072] Note: a - Change rate (%) = (Test value after N days of product use - Test value before product use) / Test value before product use * 100%, the same applies to the following tables.

[0073] Table 5: Results of skin oil content detection in Examples 1-6 (sample size = 10)

[0074] As shown in Tables 4 and 5 above, compared with before product use, after 30 minutes of product use, all examples 1-6 showed a significant effect on reducing scalp oil, with statistically significant differences (P < 0.001). However, there were significant differences in the rate of change in skin oil content. In Examples 1-3, the skin oil content changed by approximately -95% after 30 minutes of product use, demonstrating a significant oil-control effect. Example 4, which did not include "Curcuma longa extract" and "Curcuma zedoaria extract," showed a slightly weaker effect, indicating that the addition of these extracts improves the oil-control effect of the compound lotion. Examples 5 and 6, where the compound lotion's pH value was not between 5.5 and 6.5, only achieved an oil control of approximately -78%, a significantly poorer effect compared to Examples 1-3.

[0075] Table 6: Results of skin oil content detection for comparative examples 1-7 (sample size = 10)

[0076] Table 7: Results of skin oil content detection in comparative examples 1-7 (sample size = 10)

[0077] As shown in Tables 6 and 7 above, compared with before product use, after 30 minutes of product use, all Comparative Examples 1-7 showed a significant effect in reducing scalp oil, with statistically significant differences (P < 0.001). However, there were significant differences in the rate of change in skin oil content. In Comparative Examples 1-3, which did not include some surfactants, the skin oil content change rate after 30 minutes of product use was only about -81%. Comparative Examples 4-7, whose surfactant system component contents were selected within the range of Examples 1-3 of this application, also showed poor oil control, significantly different from the approximately -95% oil control achieved in Examples 1-3. This fully demonstrates that the selection of raw materials and the component content ratio of the surfactant system "cocamidopropyl betaine, sodium lauryl ether sulfate, and sodium lauroyl sarcosinate" in this application have a significant impact on the oil control effect of the compound lotion. Embodiments outside the surfactant system range of Examples 1-3 of this application showed poor oil control.

[0078] Table 8: Results of skin oil content detection for comparative examples 8-13 (sample size = 10)

[0079] Table 9: Results of skin oil content detection for comparative examples 8-13 (sample size = 10)

[0080] As shown in Tables 8 and 9 above, compared with before using the product, after 30 minutes of using the product, the comparative examples 8 to 13 all had a poor effect on reducing scalp oil.

[0081] The technical solutions of Comparative Examples 11-13, which used other conditioning agents to replace polyquaternium-10, had poor oil control effects, and the skin oil content test results showed no significant difference. The effects were far lower than those of the implementation methods in Examples 1-3 of this application.

[0082] Experiment Example 2 To further demonstrate the repairing effect of the compound shampoo of this invention, Example 1 is used as an example for verification. This study included 31 subjects (16 males and 15 females), with 31 participants ultimately completing the procedure. The participants' ages ranged from 18 to 25 years, with a mean age of 20.74 years. Based on daily usage habits, 1-2 pumps (approximately 3-5 mL) were used; short hair was washed for about 5 minutes, and long hair for no more than 10 minutes.

[0083] (I) Oil control test Measuring instrument: Skin oil content testing probe (MPA580-Sebumeter, Germany). Measurement requirements: Data collection of scalp oil content. Parameter interpretation: The higher the collected value, the higher the oil content.

[0084] Figure 1This is a comparative graph showing the results of skin oil content after use in Example 1 of this application.

[0085] Table 10: Results of skin oil content detection (sample size = 31)

[0086] Note: a - Change rate (%) = (Test value after N days of product use - Test value before product use) / Test value before product use * 100%.

[0087] Table 11: Results of the test on differences in skin oil content (sample size = 31)

[0088] Note: NS is an abbreviation for "No Significant", meaning "no significant difference", P > 0.05; "*" indicates a significant difference, 0.01 ≤ P < 0.05; "**" indicates a highly significant difference, 0.001 ≤ P < 0.01; "***" indicates a highly significant difference, P < 0.001.

[0089] (ii) Desquamation test Measuring instrument: visioscan 20 plus Corneofix (Courage & Khazaka, Germany). Measurement site: Scalp. Parameter explanation: The lower the measurement value, the less dandruff on the scalp. Skin dandruff index (SEsc) measuring instrument: visioscan 20 plus Topography (Courage & Khazaka, Germany). Measurement site: Scalp. Parameter explanation: The lower the measurement value, the less dandruff on the scalp.

[0090] Figure 2 This is a comparison chart of the skin desquamation index results after use in Example 1 of this application.

[0091] Table 12: Results of Skin Desquamation Index Detection (Sample Size = 31)

[0092] Note: a - Change rate (%) = (Test value after N days of product use - Test value before product use) / Test value before product use * 100%.

[0093] Table 13: Results of the test for differences in skin desquamation index (sample size = 31)

[0094] Note: NS is an abbreviation for "No Significant", meaning "no significant difference", P > 0.05; "*" indicates a significant difference, 0.01 ≤ P < 0.05; "**" indicates a highly significant difference, 0.001 ≤ P < 0.01; "***" indicates a highly significant difference, P < 0.001.

[0095] Figure 3 This is a comparison chart of the skin scaling index results after use in Example 1 of this application.

[0096] Table 14: Results of Skin Scaly Index Detection (Sample Size = 31)

[0097] Note: a - Change rate (%) = (Test value after N days of product use - Test value before product use) / Test value before product use * 100%.

[0098] Table 15: Results of the test for differences in skin scaling index (sample size = 31)

[0099] Note: NS is an abbreviation for "No Significant", meaning "no significant difference", P > 0.05; "*" indicates a significant difference, 0.01 ≤ P < 0.05; "**" indicates a highly significant difference, 0.001 ≤ P < 0.01; "***" indicates a highly significant difference, P < 0.001.

[0100] In summary, compared with before using the product of Example 1 of this application, after 7 days of product use, the change rate of skin scaling index was -3.54%, which was significantly different (0.01≤P<0.05). Compared with before using the product, after 14 days of product use, the change rate of skin scaling index was -4.89%, which was also significantly different (0.01≤P<0.05).

[0101] Compared with before product use, after 7 days of product use, the skin desquamation index changed by -33.22%, which was statistically significant (0.001≤P<0.01). Compared with before product use, after 14 days of product use, the skin desquamation index changed by -33.58%, which was statistically significant (P<0.001).

[0102] Compared with before product use, after 7 days of product use, the change rate of skin oil content was -48.63%, which was statistically significant (P < 0.001). Compared with before product use, after 14 days of product use, the change rate of skin oil content was -54.40%, which was statistically significant (P < 0.001).

[0103] Experimental Example 3 To further demonstrate the solubility and stabilization effects of Examples 1-6 and Comparative Examples 1-13 on traditional Chinese medicine granules, a verification experiment was conducted using Shuangbai external wash as an example.

[0104] (I) The raw material formula of the Shuangbai external wash is as follows: 3g of Phellodendron bark, 3g of Platycladus orientalis leaves, 2.5g of Portulaca oleracea, 3.3g of Lonicera japonica, 1.7g of Glycyrrhiza uralensis, and a total raw material weight of 13.5g; The preparation method of the Shuangbai external wash is as follows: after mixing the above raw materials, add 20 times the amount of water and decoct for 1.5 hours, filter, and concentrate the filtrate into a concentrated solution with a relative density of 1.03~1.06; spray dry the concentrated solution to obtain powder that passes through an 80-mesh sieve, and then dry granulate it into particles that pass through a 12-mesh sieve to obtain Shuangbai external wash particles. The dry granulation process involves mixing the sieved, spray-dried powder with 0.02% magnesium stearate and 0.02% maltodextrin by weight of the total raw materials. A 12-mesh sieve is then installed on a dry granulator, and granulation is performed by adjusting the main hydraulic cylinder pressure, roller speed, and feeding screw speed. Specifically, the hydraulic cylinder pressure is controlled at 20 MPa, the feeding speed at 150 rpm, the tableting speed at 40 rpm, and the granulation speed at 120 rpm.

[0105] (II) Dissolve 10g of Shuangbai external wash granules prepared by the above method in 100g of sample (the compound wash of this application), stir for 2-3 minutes to ensure that the medicinal granules are evenly distributed in the compound wash, and let stand at room temperature for 30-60 minutes. After standing, stir the compound mixture thoroughly for 2-3 minutes to obtain the Chinese herbal granule shampoo to be tested.

[0106] The maximum solubility of the compound Chinese medicine is as follows: after shampooing the Chinese medicine granules to be tested, pass them through a 200-mesh gauze, weigh the grams of undissolved Chinese medicine granules remaining on the gauze, and the total grams minus the grams of remaining granules is recorded as the maximum solubility.

[0107] The stability test involves storing the obtained herbal granule shampoo at 45℃, 20℃, 2℃, and -16℃ for one week to check its stability.

[0108] Table 16: Maximum solubility and stability of compound traditional Chinese medicines in Examples 1-6

[0109] As shown in the table above, the Shuangbai external wash prepared by the compound washes in Examples 1-4 of this application has a high solubility for Chinese medicine granules (the maximum solubility can reach about 9.9 grams), and it has good stability after being stored at different temperatures for one week. However, in the embodiments of Examples 5 and 6, where the pH value is not within the range of Examples 1-3, some solvents showed precipitation and flocculation after one week of storage.

[0110] Figure 4 The attached figure shows the stability of the Chinese herbal medicine granules of the Shuangbai external wash prepared using Example 1 as the compound wash for this experimental example.

[0111] Table 17: Maximum solubility and stability of compound traditional Chinese medicines in Comparative Examples 1-7

[0112] Comparative Examples 1-7 of this application are embodiments for examining the surfactant system of this application. As shown in Table 18, the embodiments of Comparative Examples 1-7 that are not within the scope of the surfactant system of Examples 1-3 of this application do not have good compatibility and stability for traditional Chinese medicine granules, and their maximum solubility and stability cannot meet the performance requirements of traditional Chinese medicine granule lotion.

[0113] Table 18: Maximum solubility and stability of compound traditional Chinese medicines in Comparative Examples 8-13

[0114] As shown in the table above, the maximum solubility of the traditional Chinese medicine granules was relatively low in Comparative Example 8 (1% nonionic solubilizer, PEG-40 hydrogenated castor oil) and Comparative Example 9 (0.1% nonionic solubilizer, PEG-40 hydrogenated castor oil). This indicates that the content of the nonionic solubilizer in this application has a certain synergistic effect with the surfactant system in this application. The implementation methods outside the nonionic solubilizer content range of Examples 1-3 of this application have poor solubility in traditional Chinese medicine granules and poor stability under high temperature conditions.

[0115] Furthermore, this experimental example uses the Shuangbai external wash prepared as a compound detergent in Example 1 as an example to conduct a self-evaluation and verification of the washing feel. The specific method is as follows: Verification method: Questionnaire survey; Validation requirements: Subjects must evaluate their experience using the product; Participants: 31 subjects were included in this test (16 males and 15 females), with 31 ultimately completing the test. The participants ranged in age from 18 to 25 years, with a mean age of 20.74 years. Based on daily usage habits, 1-2 pumps (approximately 3-5 mL) were used. Short hair was washed for about 5 minutes, and long hair for no more than 10 minutes.

[0116] Parameter explanation: Calculates the positive review rate; the higher the score, the higher the rating.

[0117] Table 19: Results of Subjects' Skin Feelings (Acceptance Level) After Using the Product

[0118] Note: "*" indicates that participants' evaluations of their experience using the product were based solely on the location where the product was used. "#": Rating criteria: 1 point indicates strong disagreement, 2 points indicates some disagreement, 3 points indicates neutral (neither agree nor disagree), 4 points indicates some agreement, and 5 points indicates strong agreement; and the percentage of participants who agree is calculated as (number of participants who rated 4 points + number of participants who rated 5 points) / total number of participants × 100. If more than 50% of participants reported improvement for a particular indicator, the product is considered to have that effect.

[0119] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the above embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the above embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A compound detergent suitable for dissolving traditional Chinese medicine, characterized in that, The compound detergent includes: (a) A surfactant system comprising 12-15% of the total mass of the compound detergent, wherein the surfactant system comprises: cocamidopropyl betaine, sodium lauryl ether sulfate and sodium lauroyl sarcosinate; The mass ratio of cocamidopropyl betaine, sodium lauryl ether sulfate, and sodium lauroyl sarcosinate is 2.0~2.5:8.0~9.0:2.8~3.2; (b) 0.3-0.7% of a nonionic solubilizer relative to the total mass of the compound detergent; (c) 0.2 to 0.4% of the cationic conditioner polyquaternium salt-10 relative to the total mass of the compound detergent.

2. The compound detergent according to claim 1, characterized in that, The nonionic solubilizer includes at least one of PEG-7 glyceryl cocoate, PEG-40 hydrogenated castor oil, and PPG-26-butanol polyether, preferably PEG-40 hydrogenated castor oil.

3. The compound detergent according to claim 1, characterized in that, The compound detergent also includes a pH adjuster, namely citric acid.

4. The compound detergent according to claim 1, characterized in that, The pH value of the compound detergent is 5.5~6.

5.

5. The compound detergent according to claim 1, characterized in that, The compound lotion also includes one or a combination of two of the following: Curcuma longa extract and Curcuma zedoaria extract.

6. The compound detergent according to any one of claims 1 to 5, characterized in that, The compound detergent comprises the following components by mass fraction: The ingredients are: cocamidopropyl betaine 1.9-2.3%, sodium lauryl ether sulfate 8.0-8.8%, sodium lauroyl sarcosinate 2.8-3.2%, nonionic solubilizer 0.3-0.7%, cationic conditioner 0.2-0.4%, pH adjuster 0.12-0.18%, Curcuma longa extract and / or Curcuma zedoaria extract 0.04-0.06%, with the balance being water.

7. The compound detergent according to claim 6, characterized in that, The compound detergent comprises the following components by mass fraction: The ingredients are: 2.1% cocamidopropyl betaine, 8.4% sodium lauryl ether sulfate, 3.0% sodium lauroyl sarcosinate, 0.5% nonionic solubilizer, 0.3% cationic conditioner, 0.155% pH adjuster, 0.05% Curcuma longa extract and / or Curcuma zedoaria extract, with the balance being water.

8. A method for preparing a compound detergent according to any one of claims 1 to 7, characterized in that, The preparation method includes: S1: Cocamidopropyl betaine, sodium lauryl ether sulfate, and sodium lauroyl sarcosinate were added to water in sequence and homogenized to obtain solution A; S2: Add nonionic solubilizer, cationic conditioner, pH adjuster and oil control component to solution A and mix well to obtain compound detergent.

9. The method for preparing the compound detergent according to claim 8, characterized in that, The homogenization temperature in step S1 is 85-90℃, and the time is 1-30 min, preferably 10 min. And / or, the mixing temperature in step S2 is 85-40℃, and the time is 1-30 min, preferably 10 min.

10. The use of the compound shampoo according to any one of claims 1 to 7 in the preparation of traditional Chinese medicine granule shampoo.

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