Bidirectional blood plasma separation device

By combining a dual-output hose design with a flat-push squeezer, the problem of simultaneous separation of upper and lower components in blood separation devices is solved, achieving stable and uniform output of blood components and improving operating efficiency and separation effect.

CN120861281APending Publication Date: 2025-10-31BEIJING JIACHENHONG BIOLOGICAL TECH CO LTD
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Patent Information

Application Number
CN202511288403.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-09-10
Publication Date
2025-10-31

AI Technical Summary

Technical Problem

Existing blood separation devices cannot achieve simultaneous separation and output of components at both ends of the blood bag, and the uneven output rate affects the separation effect. They cannot be separated and output again by inverting the blood bag, and multiple centrifugation operations are required.

Method used

The blood bag features a dual-output tubing design, combined with a flat-push squeezer and a flow controller. Blood stratification can be observed through a transparent fixing plate and an indicator scale. A spring pushes the squeezing plate to achieve stable squeezing, and the flow controller controls the flow of the upper and lower output tubing separately to ensure balanced output.

Benefits of technology

It enables the simultaneous output of blood components from both the upper and lower layers of the blood bag, improving separation efficiency and ensuring output stability and uniformity. The transparent clamp facilitates observation, the indicator scale enables quantitative control, and the flow controller balances the output rate.

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Abstract

A two-way blood plasma separating device is used for extruding and outputting liquid in a blood bag 10 and comprises a horizontal pushing extruder and a flow controller, the horizontal pushing extruder is provided with a fixing clamping plate 20 and an extruding clamping plate 30, the plate face of the extruding clamping plate 30 is parallel to the plate face of the fixing clamping plate 20, and a first output hose 11 and a second output hose 12 are arranged at the two ends of the blood bag 10. The squeezing clamping plate 30 squeezes the blood bag in the direction perpendicular to the plate face of the fixing clamping plate 20, and the flow controller 40 is provided with a first flow control valve and a second flow control valve. The blood bag provided with the double output hoses is adopted, the horizontal pushing squeezer is adopted for horizontally pushing and squeezing the blood bag, simultaneous output of upper and lower layers of blood components in the blood bag can be achieved, the blood bag can be stably and evenly squeezed, and the flow controller can control the flow of the two output hoses of the blood bag and balance the output speed of the upper and lower blood components. And the flow controller is divided into an upper valve body and a lower valve body, so that loading and unloading of the output hose are facilitated.
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Description

Technical Field

[0001] This invention relates to blood plasma separation technology, and more particularly to a bidirectional blood plasma separation device. Background Technology

[0002] Blood plasma separation technology refers to the separation of various components in blood after centrifugation, according to different needs. After centrifugation, the different components of the blood in the blood bag will form a layered state (e.g., red blood cell layer, white blood cell layer, and plasma layer). Most existing blood plasma separation devices use blood plasma separation clamps to physically squeeze the different components out of the blood bag step by step, achieving the separation of different blood components. This type of blood plasma separation clamp can meet the needs of ordinary blood testing and plasma separation. However, the unidirectional fan-shaped clamp structure usually only squeezes the components at the top of the blood bag out of the blood bag, which is not suitable for separating the upper and lower components of the blood bag at the same time. Even after squeezing out the components at the top of the blood bag, two or more components at the bottom will mix, making it impossible to separate and output them again by inverting the blood bag, or requiring multiple centrifugations to separate the multi-layered blood components. There are also some blood plasma separation clamp solutions using parallel clamps in the existing technology, such as Chinese invention patent (application number 2015202193672), but these technical solutions do not provide a method to achieve simultaneous plasma output from both ends of the blood bag. Simultaneous separation of blood components from both the top and bottom of the blood bag requires stable squeezing and precise control. Effective flow control and balanced output rates are essential for bidirectional blood component separation, as varying output rates can affect the separation outcome. Accurate output control also necessitates clear observation of changes in the liquid level within the blood bag. Summary of the Invention

[0003] The purpose of this invention is to provide a bidirectional blood separation device to achieve reliable bidirectional blood component output from blood bags.

[0004] To achieve the above objectives, the technical solution of the present invention is: a bidirectional blood separation device for squeezing out liquid from a blood bag (10), characterized in that it includes a flat-push squeezer and a flow controller, the flat-push squeezer is provided with a fixed clamping plate (20) and a squeezing clamping plate (30), the plate surface of the squeezing clamping plate (30) is parallel to the plate surface of the fixed clamping plate (20), the two ends of the blood bag (10) are provided with a first output hose (11) and a second output hose (12), the squeezing clamping plate (30) squeezes the blood bag in a direction perpendicular to the plate surface of the fixed clamping plate (20), the flow controller (40) is provided with a first flow control valve and a second flow control valve, the first flow control valve compresses the first output hose (11), and the second flow control valve compresses the second output hose (12).

[0005] Furthermore, in order to clearly observe the blood component separation process, the fixing clamp (20) is a transparent plate.

[0006] Furthermore, in order to precisely control the separation of blood components, the fixing clamp (20) is provided with an indicator scale (21). The indicator scale is a transparent scale that adjusts the displacement in the vertical direction. The indicator scale has a dovetail structure in cross-section. The fixing clamp is provided with a dovetail groove (22) corresponding to the indicator scale. The indicator scale slides in the dovetail groove. The center of the indicator scale is provided with a central engraving line (21a). The upper and lower sides of the central engraving line are respectively provided with equidistant engraving lines (21b).

[0007] Furthermore, in order to make the extrusion clamp (30) move parallel to the fixed clamp (20), the flat extruder is provided with a transmission plate (50), the extrusion clamp (30) is provided with a drive shaft (31) connected to the transmission plate, the drive shaft is perpendicular to the plate surface of the extrusion clamp, the flat extruder is provided with a drive spring (51), the drive spring (51) is sleeved on the spring guide shaft (52), the drive spring (51) pushes the transmission plate (50) to make the extrusion clamp (30) move towards the fixed clamp.

[0008] Furthermore, in order to ensure the stability of the transmission force and the accuracy of the transmission direction, the extrusion clamp is provided with two drive shafts (31), which are symmetrically arranged on the extrusion clamp (30). The flat extruder is provided with two drive springs (51), which are symmetrically arranged on the upper and lower sides relative to the transmission plate (50).

[0009] Furthermore, a driving structure for a flat-push extruder is provided, wherein the flat-push extruder is provided with a driving link (60), a driving rocker (61) and a driving handle (62), wherein the driving handle (62) drives the driving rocker (61) to rotate, the driving rocker (61) drives the driving link (60) to move, and the driving link (60) drives the transmission plate (50) to compress the driving spring (51).

[0010] Furthermore, in order to facilitate the connection of the blood output device, the ends of the first output hose (11) and the second output hose (12) are respectively provided with Luer connectors (13).

[0011] Furthermore, the flow controller has the following structure: the flow controller (40) is provided with a first hose channel (41) and a second hose channel (42), the first output hose (11) passes through the first hose channel (41), and the second output hose (12) passes through the second hose channel (42). The flow controller is provided with a first control valve core (43), a first valve stem (44), a second control valve core (45), and a second valve stem (46). The first valve stem (44) pushes the first control valve core (43) to squeeze the first output hose (11), and the second valve stem (46) pushes the second control valve core (45) to squeeze the second output hose (12).

[0012] Furthermore, to facilitate the connection between the flow controller and the first output hose (11) and the second output hose (12), the flow controller is provided with a bottom valve body (71) and an upper valve body (72). The bottom valve body (71) and the upper valve body (72) are movably connected. The bottom valve body (71) is provided with a first hose bottom groove (73) and a second hose bottom groove (74) on the docking surface. The upper valve body (72) is provided with a first hose upper groove (75) and a second hose upper groove (76) on the docking surface. After the bottom valve body (71) and the upper valve body (72) are connected, the first soft bottom groove (73) and the first hose upper groove (75) form the first hose channel (41). The second hose bottom groove, (74) and the second hose upper groove (76) form the second hose channel (42). A docking positioning pin (77) is provided between the bottom valve body (71) and the upper valve body (72). The bottom valve body and the upper valve body are fixedly connected by bolts.

[0013] Furthermore, a preferred valve core driving structure is as follows: the first control valve core (43) and the second control valve core (45) are disposed on the upper valve body (72). The upper valve body (72) is provided with a first valve core hole (78) and a second valve core hole. The first valve core hole and the second valve core hole are square holes. The first control valve core (43) is a cuboid that slides in the first valve core hole (78). The first control valve core (43) is provided with an arc-shaped head that squeezes the first output hose. The first control valve core is provided with a first screw hole (43b). The first valve stem (44) is provided with a screw. The first valve stem drives the first control valve core (43) to slide in the first valve core hole (78) through the screw. The second control valve core (45) is a cuboid that slides in the second valve core hole. The second control valve core is provided with an arc-shaped head that squeezes the second output hose. The second control valve core is provided with a second screw hole (45b). The second valve stem (46) is provided with a screw. The second valve stem drives the second control valve core (45) to slide in the first valve core hole through the screw.

[0014] The beneficial effects of this invention are as follows: A blood bag with dual output hoses is used, and a flat-push squeezer is employed for flat-push compression of the blood bag, enabling simultaneous output of the upper and lower layers of blood components within the blood bag. The spring-driven compression operation ensures stable and uniform compression of the blood bag. A transparent fixing clamp facilitates observation of the blood bag, and an indicator scale allows for quantitative observation and control of the blood stratification. A flow controller can separately control the flow rate of the two output hoses of the blood bag, balancing the output speed of the upper and lower blood components and ensuring separation effectiveness. The flow controller is divided into upper and lower valve bodies, facilitating the loading and unloading of the output hoses.

[0015] The present invention will now be described in detail with reference to the accompanying drawings and embodiments. Attached Figure Description

[0016] Figure 1 This invention comprises a flat-push extruder, a flow controller, and a blood bag; Figure 2 This is a structural diagram of the flat-push extruder of the present invention, omitting the outer shell; Figure 3 yes Figure 2 View from direction A; Figure 4 This is an exploded view of the structure of the flat-push extruder of the present invention; Figure 5 This is a structural diagram of the flow controller assembly of the present invention; Figure 6 This is an exploded view of the flow controller structure of the present invention; Figure 7 This is a cross-sectional view of the flow controller of the present invention; Figure 8 This is a schematic diagram of the operation of the present invention, showing the blood bag being placed in the gap between the fixing clamp and the squeezing clamp; Figure 9 This is a schematic diagram of the operation of the present invention, showing the blood bag being clamped between a fixed clamping plate and a squeezing clamping plate; Figure 10 This is a schematic diagram of the invention, showing how the lines on the indicator scale correspond to the blood layers inside the blood bag; Figure 11 This is a schematic diagram of the operation of the present invention, which controls the stable output of blood components in the upper and lower layers. Detailed Implementation

[0017] like Figure 1 As shown, a bidirectional blood separation device includes a pusher squeezer, a flow controller, and a blood bag.

[0018] like Figure 1As shown, the blood bag 10 is a transparent, flexible blood bag. The blood bag has an upper outlet and a lower outlet. The lower outlet 14 is connected to the first outlet hose 11, and the upper outlet 15 is connected to the second outlet hose 12. A Luer connector 13 is provided at each end of the first outlet hose 11 and the second outlet hose 12. The Luer connector allows for quick and safe connection to other hoses, improving work efficiency.

[0019] like Figures 1 to 4 The flat extruder includes a fixed clamping plate 20, an extrusion clamping plate 30, a base plate 23, a front baffle 24, and a rear baffle 25. The base plate 23 is horizontally set, and the front baffle 24 and the rear baffle 25 are vertically fixed on the base plate 23 to form the frame of the flat extruder. The front baffle 24 and the rear baffle 25 are reinforced by a crossbeam 26.

[0020] A fixing plate 20 is vertically fixed to the front end of the floor 23. The fixing plate 20 is a transparent plate made of a transparent material (such as plexiglass). The fixing plate 20 is equipped with an indicator scale 21, which is a transparent scale for adjusting displacement in the vertical direction. The indicator scale has a central graduation line 21a in the middle, and equidistant graduation lines 21b on both the upper and lower sides of the central graduation line 21a. The indicator scale has a dovetail cross-section, and the fixing plate 20 has a dovetail groove 22 corresponding to the indicator scale. The indicator scale 21 slides within the dovetail groove 22, adjusting its position in the fixing plate 20 in the vertical direction. The indicator scale 21 has a horizontally oriented open plate 21c at its upper end. The upper end of the fixed clamping plate 20 has an adjusting seat 27. The adjusting seat 27 has an adjusting screw hole 28. There is an adjusting screw 29 in the adjusting screw hole 28. The adjusting screw 29 is embedded in the open plate 21c. By rotating the two ends 29, the indicator scale 21 can slide in the dovetail groove 22.

[0021] The surface of the extrusion clamp 30 is parallel to the surface of the fixed clamp 20. The extrusion clamp 30 is provided with two drive shafts 31, which are symmetrically arranged vertically and perpendicular to the surface of the extrusion clamp 30. The two drive shafts 31 are slidably engaged with the drive shaft guide holes 31a on the front baffle 24, so that the extrusion clamp 30 moves in a direction perpendicular to the surface of the fixed clamp 20, and the surface of the extrusion clamp 30 approaches or moves away from the surface of the fixed clamp 20.

[0022] The drive shaft 31 passes through the front baffle 24 and connects to the transmission plate 50. The flat extruder is equipped with two drive springs 51, which are symmetrically arranged vertically relative to the transmission plate 50. A spring guide shaft 52 is provided between the front baffle 24 and the rear baffle 25. The drive springs 51 are sleeved on the spring guide shaft 52. One end of the drive spring 51 presses against the rear baffle 25, and the other end of the drive spring 51 presses against the transmission plate 50. The drive springs 51 push the transmission plate 50, causing the extrusion clamping plate 30 to move towards the fixed clamping plate.

[0023] The flat extruder is equipped with a drive link 60, a drive rocker arm 61, and a drive handle 62. One end of the drive link 60 is hinged to the transmission plate 50, and the other end of the drive link 60 is hinged to the drive rocker arm 61. The drive handle 62 drives the drive rocker arm 61 to rotate, the drive rocker arm 61 drives the drive link 60 to move, and the drive link 60 drives the transmission plate 50 to compress the drive spring 51, causing the extrusion clamping plate 30 to move away from the fixed clamping plate 20.

[0024] When using the flat-push squeezer, crank the drive handle 62 to increase the gap between the squeeze clamp 30 and the fixed clamp 20, allowing the blood bag to be placed between the squeeze clamp 30 and the fixed clamp 20. When the drive handle 62 is released, the squeeze clamp 30 can press the blood bag firmly onto the fixed clamp 20 under the elastic force of the drive spring 51.

[0025] like Figures 5 to 7 The flow controller 40 is provided with a bottom valve body 71 and an upper valve body 72. The bottom valve body 71 and the upper valve body 72 are movably connected. A docking positioning pin 77 is provided between the bottom valve body 71 and the upper valve body 72. The docking positioning pin 77 is fixed on the bottom valve body 71. The upper valve body 72 is provided with a pin hole 70. The bottom valve body and the upper valve body are fixedly connected by bolts.

[0026] The bottom valve body 71 has a first soft tube bottom groove 73 and a second soft tube bottom groove 74 on its mating surface. The upper valve body 72 has a first soft tube upper groove 75 and a second soft tube upper groove 76 on its mating surface. After the bottom valve body 71 and the upper valve body 72 are mated, the first soft tube bottom groove 73 and the first soft tube upper groove 75 form a first soft tube channel 41, and the second soft tube bottom groove 74 and the second soft tube upper groove 76 form a second soft tube channel 42. The first soft tube channel 41 and the second soft tube channel 42 are circular through holes. The first soft tube channel 41 corresponds to the first output tube 11 of the blood bag, that is, the diameter of the first soft tube channel 41 is slightly larger than the diameter of the first output tube 11; the second soft tube channel 42 corresponds to the second output tube 12, that is, the diameter of the second soft tube channel 42 is slightly larger than the diameter of the second output tube 12, so that the first output tube 11 can pass smoothly through the first soft tube channel 41, and the second output tube 12 can pass smoothly through the second soft tube channel 42.

[0027] The flow controller is provided with a first control valve core 43, a first valve stem 44, a second control valve core 45, and a second valve stem 46. The first valve stem 44 pushes the first control valve core 43 to squeeze the first output hose 11, and the second valve stem 46 pushes the second control valve core 45 to squeeze the second output hose 12.

[0028] The first control valve core 43 and the second control valve core 45 are disposed on the upper valve body 72, and the upper valve body 72 is provided with a first valve core hole 78 and a second valve core hole 79.

[0029] The first valve core hole 78 is a square hole that penetrates the upper valve body 72 and connects to the upper groove 75 of the first flexible hose. The first control valve core 43 is a cuboid that slides within the first valve core hole 78. One end of the first control valve core 43 is provided with an arc-shaped head 43a for compressing the first output flexible hose, and the other end is provided with a first threaded hole 43b. The first valve stem 44 is provided with a screw 44a, which drives the first control valve core 43 to slide within the first valve core hole 78 via a thread. The first valve stem 44 is provided with a first stepped shaft 44b, and the upper end of the first valve core hole 78 is provided with a stepped hole 44c to accommodate the first stepped shaft 44b. The first valve stem 44 is mounted on the upper valve body 72 via a first pressure plate 44d. The first valve stem 44 rotates on the upper valve body 72 but cannot move axially. The upper end of the first valve stem 44 is provided with a first adjusting knob 47, which drives the first valve stem to rotate. The first adjusting knob 47 has a scale, and the first pressure plate 44d has a scale pointer, enabling quantitative adjustment of the first control valve core. The position of the first control valve core can be adjusted via the first valve stem 44, changing the pressure applied to the first output hose 11 in the first hose passage 41, thereby adjusting the damping of the liquid flow within the first output hose 11. When the first control valve core 43 fully compresses the first output hose 11, the liquid flow within the first output hose 11 can be interrupted. Using an arc-shaped head 43a to compress the first output hose 11 avoids damage to the first output hose. A first expansion groove 73a is provided on the bottom valve body 71 at the position corresponding to the first control valve core 43. The first expansion groove 73a can accommodate the compressed and deformed first output hose 11, ensuring the stability of flow control.

[0030] Similarly, the second valve core hole is also a square hole, penetrating the upper valve body 72 and connecting to the upper groove 76 of the second flexible hose. The second control valve core 45 is a cuboid that slides within the second valve core hole. One end of the second control valve core 45 has an arc-shaped head 45a for compressing the second output flexible hose, and the other end has a second threaded hole 45b. The second valve stem 46 has a screw 46a, which drives the second control valve core 45 to slide within the second valve core hole via the thread. The second valve stem 46 has a second stepped shaft 46b, and the upper end of the second valve core hole has a stepped hole 46c to accommodate the second stepped shaft 46b. The second valve stem 46 is mounted on the upper valve body 72 via a second pressure plate 46d, and rotates on the upper valve body 72. The upper end of the second valve stem 46 has a second adjusting knob 48, which drives the second valve stem to rotate. The second adjusting knob 48 has a scale, and the second pressure plate 46d has a scale pointer, enabling quantitative adjustment of the second control valve core. The position of the second control valve core can be adjusted via the second valve stem 46, changing the pressure on the second output hose 12 in the second hose passage 42, thereby adjusting the damping of the liquid flow within the second output hose 12. When the second control valve core 45 fully compresses the second output hose 12, the liquid flow within the second output hose 12 can be interrupted. Using an arc-shaped head 45a to compress the second output hose 12 can avoid damage to the second output hose. A second expansion groove 74a is provided on the bottom valve body 71 at the position corresponding to the second control valve core 45. The second expansion groove 74a can accommodate the compressed and deformed second output hose 12, ensuring the stability of flow control.

[0031] like Figures 8 to 11 During the blood separation process, the blood bags containing plasma are centrifuged, and the different components of the blood in the blood bags will form a layered state. In this embodiment, after centrifugation, the blood components in the blood bags are divided into three layers: the upper layer is the red blood cell layer 16, the middle layer is the white blood cell layer 17, and the lower layer is the plasma layer 18.

[0032] First, crank the drive handle 62 to create a sufficient gap between the fixed clamp 20 and the compression clamp 30. Place the blood bag 10 into the gap between the fixed clamp and the compression clamp, and align the center of the blood bag approximately with the center mark 21a of the indicator scale. Figure 8 As shown.

[0033] Then, release the drive handle 62. Under the action of the drive spring 51, the squeeze clamp 30 moves towards the fixed clamp 20, clamping the blood bag 10 between the fixed clamp 20 and the squeeze clamp 30. Figure 9 As shown. Adjust the indicator scale 21 so that the scale lines correspond to the blood layers within the blood bag, for example, so that the upper and lower layers correspond to the equidistant scale lines 21b on the upper and lower sides respectively. Figure 10 As shown.

[0034] Next, separate the bottom valve body 71 and the upper valve body 72 of the flow controller. Lift the upper valve body 72 and place the first output tubing 11 of the blood bag into the first tubing bottom groove 73 of the bottom valve body 71 and the second output tubing 12 into the second tubing bottom groove 74 of the bottom valve body 71. Fasten the bottom valve body 71 and the upper valve body 72 together. Rotate the first adjusting knob 47, and the first control valve core 43 will fully press the first output tubing 11, causing the first output tubing to be in a flow-off state. Rotate the second adjusting knob 48, and the second control valve core 45 will fully press the second output tubing 12, causing the second output tubing to be in a flow-off state.

[0035] Next, open the Luer connectors of the first and second output hoses. Then, rotate the first adjusting knob 47 and the second adjusting knob 48 to adjust the opening of the first and second output hoses. The upper red blood cell layer 16 in the blood bag is discharged through the first output hose 11, and the lower plasma layer 18 is discharged through the second output hose 12. During this process, observe the changes in the stratification of different components in the blood bag 10, and adjust the pressure of the first control valve core 43 on the first output hose 11 and the pressure of the second control valve core 45 on the second output hose 12 in a timely manner to ensure a balanced and stable output of the blood components in both layers. Figure 11 As shown.

[0036] The process continues until the upper red blood cell layer 16 and the lower plasma layer 18 are completely drained from the blood bag, while the middle white blood cell layer 17 remains inside the blood bag.

[0037] Then, the first control valve core 43 fully compresses the first output hose 11, and the second control valve core 45 fully compresses the second output hose 12, closing both the first and second output hoses 11 and 12. The Luer connectors of the first and second output hoses are then closed. The bottom valve body 71 and the upper valve body 72 are separated, and the first and second output hoses 11 and 12 of the blood bag are removed. The drive handle 62 is cranked to separate the fixing clamp 20 from the squeezing clamp 30, and the blood bag is removed. This completes the blood separation operation.

[0038] This invention utilizes a blood bag with dual output tubing and employs a flat-push squeezer to simultaneously output the upper and lower layers of blood components within the bag. A single blood separation operation can discharge two different components, significantly improving the efficiency of blood separation. The spring-driven squeezing mechanism ensures stable and uniform compression of the blood bag, making it more convenient than manual squeezing and guaranteeing the bag's safety. A transparent clamp facilitates observation of the blood bag, and an indicator scale allows for quantitative observation and control of the blood stratification. The movable indicator scale allows for accurate alignment with the blood stratification position. A flow controller independently controls the flow rate of the two output tubings, balancing the output speed of the upper and lower blood components to ensure effective separation. The flow controller consists of upper and lower valve bodies for easy loading and unloading of the blood bag's output tubing. A control valve core with an arc-shaped head effectively controls the flow rate of the output tubing, and a graduated adjustment knob allows for quantitative flow rate adjustment.

Claims

1. A bidirectional blood separation device for squeezing and discharging liquid from a blood bag (10), characterized in that, The device includes a flat-push squeezer and a flow controller. The flat-push squeezer is provided with a fixed clamp (20) and a squeeze clamp (30). The surface of the squeeze clamp (30) is parallel to the surface of the fixed clamp (20). The blood bag (10) is provided with a first output hose (11) and a second output hose (12) at both ends. The squeeze clamp (30) squeezes the blood bag in a direction perpendicular to the surface of the fixed clamp (20). The flow controller (40) is provided with a first flow control valve and a second flow control valve. The first flow control valve compresses the first output hose (11), and the second flow control valve compresses the second output hose (12).

2. The bidirectional blood plasma separation device according to claim 1, characterized in that, The fixing clamp (20) is a transparent plate.

3. The bidirectional blood separation device according to claim 1, characterized in that, The fixed clamp (20) is provided with an indicator scale (21). The indicator scale is a transparent scale that adjusts the displacement in the vertical direction. The indicator scale has a dovetail structure in cross-section. The fixed clamp is provided with a dovetail groove (22) corresponding to the indicator scale. The indicator scale slides in the dovetail groove. The middle part of the indicator scale is provided with a central engraving line (21a). The upper and lower sides of the central engraving line are respectively provided with equidistant engraving lines (21b).

4. The bidirectional blood separation device according to claim 1, characterized in that, The flat extruder is provided with a transmission plate (50), and the extrusion clamp (30) is provided with a drive shaft (31) connected to the transmission plate. The drive shaft is perpendicular to the plate surface of the extrusion clamp. The flat extruder is provided with a drive spring (51), and the drive spring (51) is sleeved on the spring guide shaft (52). The drive spring (51) pushes the transmission plate (50) to move the extrusion clamp (30) toward the fixed clamp.

5. The bidirectional blood separation device according to claim 4, characterized in that, The extrusion clamp is provided with two drive shafts (31), which are symmetrically arranged on the extrusion clamp (30). The flat extruder is provided with two drive springs (51), which are symmetrically arranged on the upper and lower sides relative to the transmission plate (50).

6. The bidirectional blood separation device according to claim 4, characterized in that, The flat extruder is provided with a drive link (60), a drive rocker (61) and a drive handle (62). The drive handle (62) drives the drive rocker (61) to rotate, the drive rocker (61) drives the drive link (60) to move, and the drive link (60) drives the transmission plate (50) to compress the drive spring (51).

7. The bidirectional blood separation device according to claim 1, characterized in that, The ends of the first output hose (11) and the second output hose (12) are respectively provided with Luer connectors (13).

8. The bidirectional blood separation device according to claim 1, characterized in that, The flow controller (40) is provided with a first hose channel (41) and a second hose channel (42). The first output hose (11) passes through the first hose channel (41), and the second output hose (12) passes through the second hose channel (42). The flow controller is provided with a first control valve core (43), a first valve stem (44), a second control valve core (45), and a second valve stem (46). The first valve stem (44) pushes the first control valve core (43) to squeeze the first output hose (11), and the second valve stem (46) pushes the second control valve core (45) to squeeze the second output hose (12).

9. The bidirectional blood separation device according to claim 8, characterized in that, The flow controller is provided with a bottom valve body (71) and an upper valve body (72). The bottom valve body (71) and the upper valve body (72) are movably connected. The bottom valve body (71) is provided with a first hose bottom groove (73) and a second hose bottom groove (74) on the docking surface. The upper valve body (72) is provided with a first hose upper groove (75) and a second hose upper groove (76) on the docking surface. After the bottom valve body (71) and the upper valve body (72) are connected, the first hose bottom groove (73) and the first hose upper groove (75) form the first hose channel (41). The second hose bottom groove, the second hose upper groove (74) and the second hose upper groove (76) form the second hose channel (42). A docking positioning pin (77) is provided between the bottom valve body (71) and the upper valve body (72). The bottom valve body and the upper valve body are fixedly connected by bolts.

10. The bidirectional blood separation device according to claim 9, characterized in that, The first control valve core (43) and the second control valve core (45) are disposed on the upper valve body (72). The upper valve body (72) is provided with a first valve core hole (78) and a second valve core hole. The first valve core hole and the second valve core hole are square holes. The first control valve core (43) is a cuboid that slides in the first valve core hole (78). The first control valve core (43) is provided with an arc-shaped head that squeezes the first output hose. The first control valve core is provided with a first screw hole (43b). The first valve stem (44) is provided with a screw. The first valve stem drives the first control valve core (43) to slide in the first valve core hole (78) through the thread. The second control valve core (45) is a cuboid that slides in the second valve core hole. The second control valve core is provided with an arc-shaped head that squeezes the second output hose. The second control valve core is provided with a second screw hole (45b). The second valve stem (46) is provided with a screw. The second valve stem drives the second control valve core (45) to slide in the first valve core hole through the thread.