Blood component separator and separation method

Abstract

The invention relates to the technical field of medical instruments, and discloses a blood component separator and a separation method, the blood component separator comprises a main machine body, an extrusion mechanism, a mounting mechanism and a uniform mixing mechanism; the extrusion mechanism comprises a moving plate and an extrusion driving assembly; the extrusion driving assembly is used for driving the moving plate to move; the uniform mixing mechanism comprises a tray and a uniform mixing driving assembly, and the uniform mixing driving assembly is used for driving the tray to rotate between a first position and a second position; after the mother bag is extruded and separated and a preservative solution or other liquid is injected into the mother bag, the liquid in the mother bag can be uniformly mixed by overturning the tray, then the tray is rotated back to the first position, and the mother bag can be continuously extruded and separated after standing and layering, so that the mother bag does not need to be manually taken and placed for many times; and the primary bag can be subjected to extrusion separation, liquid injection, uniform mixing and secondary extrusion separation on line, so that the operation continuity is guaranteed, the manual intervention is reduced, and the treatment efficiency is improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to a blood component separation machine and a separation method. BACKGROUND

[0002] The blood component separation machine is used for separating different components in blood, and is usually provided with a blood component separation machine for hanging a blood bag (a mother bag) containing components to be separated. The blood bag is squeezed by moving a movable squeezing plate, so that the components to be separated (such as blood plasma) are squeezed out of the mother bag and sent to other containers (such as other blood bags) through a pipeline. In the related art, after the blood component separation machine separates the components in the mother bag, red blood cells are retained in the mother bag, and a red blood cell preservation solution is injected into the mother bag. Then, the mother bag needs to be manually taken down and placed in a shaking device for shaking or manually shaken, which has the problems of complicated operation, poor continuity, uneven mixing, and the like, and affects the separation effect and component quality. SUMMARY

[0003] The present application aims to at least solve one of the technical problems existing in the prior art. To this end, the present application provides a blood component separation machine and a separation method.

[0004] In a first aspect, the blood component separation machine of the embodiments of the present application comprises a main body, a squeezing mechanism, a hanging mechanism and a mixing mechanism.

[0005] One side of the main body has a fixed plate;

[0006] The squeezing mechanism comprises a movable plate and a squeezing driving assembly. The movable plate is arranged opposite to the fixed plate. The squeezing driving assembly is connected to the main body and the movable plate, and is used to drive the movable plate to move to approach or move away from the fixed plate.

[0007] The hanging mechanism is connected to the main body.

[0008] The mixing mechanism comprises a tray and a mixing driving assembly. The mixing driving assembly is connected to the main body and the tray, and is used to drive the tray to rotate between a first position and a second position. In the first position, the tray is located between the movable plate and the fixed plate and below the hanging mechanism. The hanging mechanism is at least partially located on the side of the tray away from the fixed plate, and is used to hang the blood bag. In the second position, the tray is at least partially rotated to a position higher than the hanging mechanism, so that the bottom of the blood bag is turned to above the hanging position.

[0009] According to the blood component separation machine provided by the embodiments of the present application, the following advantages are achieved: the blood components can be separated accurately and efficiently. After the mother bag is separated by extrusion, the remaining components in the mother bag and the newly added liquid can be mixed by turning the tray, and the tray can be turned back to the first position after the mixing operation. The mother bag can be separated by extrusion again after being separated by layering. The mother bag can be separated by extrusion, liquid injection, mixing and extrusion again on line, which ensures the continuity of the operation, improves the processing efficiency, and reduces the adverse effects of the mounting position error and the poor mixing effect caused by manual intervention on the separation effect.

[0010] According to the blood component separation machine provided by some embodiments of the present application, a plurality of sensors are arranged on the outer side of the fixed plate in the vertical direction. The tray is provided with a first avoiding opening penetrating through both sides of the tray. When the tray is located at the first position, the first avoiding opening corresponds to the sensor, and the sensor is used to detect the layering surface of the remaining blood components in the blood bag through the first avoiding opening.

[0011] According to the blood component separation machine provided by some embodiments of the present application, the main body includes a cabinet, the fixed plate is fixed to one side of the cabinet, and the sensor is arranged on the side of the cabinet facing the fixed plate. The fixed plate is provided with a second avoiding opening corresponding to the position of the sensor, which is used to avoid the sensor.

[0012] Alternatively, the fixed plate serves as a side wall of the main body, and the fixed plate has a containing groove for containing the sensor. The sensor is contained in the containing groove and fixedly connected to the fixed plate.

[0013] According to the blood component separation machine provided by some embodiments of the present application, the tray has opposite first and second extrusion surfaces. When the tray is located at the first position, the first extrusion surface abuts against the fixed plate, and the second extrusion surface faces the moving plate and is used to abut against the outer wall of one side of the blood bag and is arranged in parallel with the moving plate. According to the blood component separation machine provided by some embodiments of the present application, when the tray is located at the second position, the second extrusion surface has an included angle with the fixed plate, and the included angle is obtuse.

[0014] According to the blood component separation machine provided by some embodiments of the present application, the upper end of the tray is provided with a notch corresponding to the position of the mounting mechanism, which is used to avoid the mounting mechanism during the turning of the tray.

[0015] According to some embodiments of the present application, the blood component separator comprises a mixing driving assembly, which comprises a mixing motor and a transmission device, the mixing motor is fixed to the main body, the transmission device connects the output end of the mixing motor and the tray, and the mixing motor drives the tray to rotate through the transmission device to control the rotation angle and frequency of the tray.

[0016] According to some embodiments of the present application, the blood component separator comprises a hanging mechanism, which comprises:

[0017] A connecting piece is movably connected to the main body along the first direction, one side of the connecting piece is provided with a first inclined surface, the first inclined surface is inclined forward and downward along the first direction, and the connecting piece is provided with an abutting portion at the rear side of the first inclined surface;

[0018] A hanging needle assembly is connected to the connecting piece and extends forward along the first direction, the hanging needle assembly is located above the fixed plate and is used for hanging a blood bag;

[0019] A linkage assembly is connected to the extrusion driving assembly and the connecting piece, the linkage assembly is driven by the extrusion driving assembly and moves with the movement of the moving plate;

[0020] When the moving plate is located at the initial position, the linkage assembly abuts against the first inclined surface to limit the backward movement of the connecting piece; when the moving plate moves forward of the initial position, the linkage assembly keeps abutting against the first inclined surface; when the moving plate moves backward of the initial position, the linkage assembly abuts against the abutting portion at the set position to drive the connecting piece to move backward.

[0021] According to some embodiments of the present application, the main body is provided with a control module and a detection module, the detection module is used for detecting at least one of the running state of the extrusion mechanism, the running state of the hanging mechanism and the running state of the mixing mechanism, the control module is communicatively connected to the extrusion mechanism and the mixing mechanism, and the control module is used for controlling the start and stop of the extrusion mechanism and the mixing mechanism according to the data of the detection module.

[0022] In the second aspect, the blood component separation method according to the embodiments of the present application is applied to the blood component separator according to any one of the embodiments of the first aspect, and the separation method comprises the following steps.

[0023] The tray is located at the first position, and the centrifuged blood mother bag is hung on the hanging mechanism;

[0024] The mobile plate is moved towards the tray direction by the extrusion driving assembly and extrudes the mother bag to extrude the first component of blood in the mother bag into the first component bag in communication with the mother bag, and stops the passage of the first component bag and the mother bag;

[0025] The mobile plate is moved to the avoiding position, the mother bag is injected with the maintenance liquid, and the tray is driven to rotate at a preset angle and frequency for multiple times by the mixing driving assembly, so that the tray is located at the first position.

[0026] According to the blood component separation method, the extrusion separation is realized by the mobile plate, the online mixing after liquid injection is realized by the tray, no additional manual operation mixing is needed, and the efficient and accurate separation of blood components is facilitated.

[0027] Additional aspects and advantages of the application will be described in part below, will become apparent from the following description, or will be learned by practice of the application. BRIEF DESCRIPTION OF DRAWINGS

[0028] Figure 1 It is a schematic diagram of a blood component separation machine according to an embodiment of the application, which shows the state of the tray in the first position;

[0029] Figure 2 It is another state schematic diagram of the embodiment shown, which shows the state of the tray in the second position; Figure 1

[0030] Figure 3 It is a front view of a blood component separation machine according to an embodiment of the application;

[0031] Figure 4 It is a structural schematic diagram of a mixing mechanism in an embodiment of the application, which shows the state of the tray in the second position;

[0032] Figure 5 It is a front view of a mixing mechanism in an embodiment of the application, which shows the state of the tray in the first position;

[0033] Figure 6 It is a partial structural schematic diagram of a mounting mechanism and an extrusion mechanism in an embodiment of the application;

[0034] Figure 7 It is another state schematic diagram of the structure shown, which shows the state of the mobile plate in the initial position; Figure 6

[0035] Figure 8 It is a schematic diagram of a four-component blood bag.

[0036] Reference signs: ​​

[0037] A host body 100;

[0038] A fixed plate 110; a second avoiding port 111; a containing groove 112;

[0039] A case 120;

[0040] A hanging mechanism 200;

[0041] A connecting piece 210; a first inclined surface 211; an abutting part 212;

[0042] A hanging needle assembly 220;

[0043] A linkage assembly 230; a guide piece 231; a first guide groove 2311; a second guide groove 2312; a follower 232; a first stroke 232a; a second stroke 232b; a second inclined surface 2321; a guide part 2322;

[0044] A pressing mechanism 300;

[0045] A moving plate 310;

[0046] A pressing driving assembly 320; a pressing motor 321; a synchronous belt mechanism 322; a driving shaft 323; a driving piece 324;

[0047] A first fixed plate 330; a second fixed plate 340; a top pressing plate 350;

[0048] A mixing mechanism 400;

[0049] A tray 410; a first avoiding port 411; a first pressing surface 412; a second pressing surface 413; a notch 414;

[0050] A mixing driving assembly 420; a mixing motor 421; a transmission device 422; a rotating shaft 423;

[0051] A sensor 500;

[0052] A plunger pulling mechanism 600; a plunger pulling rod 610; a rotating mechanism 620;

[0053] An initial position A; an original position B; a mother bag C; a first separated liquid bag D; a second separated liquid bag E; a maintenance liquid bag F. DETAILED DESCRIPTION

[0054] The concept and the resulting technical effects of the present application will be described below in conjunction with embodiments so as to fully understand the purposes, features and effects of the present application. Obviously, the described embodiments are only some of the embodiments of the present application, but not all the embodiments. Based on the embodiments of the present application, other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0055] In the description of the embodiments of the present application, if the orientation description such as "upper", "lower", "front", "back", "left", "right" and the like indicates the orientation or positional relationship shown in the drawings, it is only for the convenience of describing the present application and simplifying the description, and does not indicate or imply that the device or apparatus referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application.

[0056] In the description of the embodiments of the present application, if a certain feature is referred to as "set", "fixed", "connected", "mounted" on another feature, it can be directly set, fixed, connected or mounted on the other feature, or indirectly set, fixed, connected or mounted on the other feature. In the description of the embodiments of the present application, if "several" is referred to, it means more than one, if "multiple" is referred to, it means more than two, and if "greater than", "less than", "exceeds" is referred to, it should be understood as not including the number itself, if "and above", "and below", "and within" are referred to, it should be understood as including the number itself. If "first", "second" are referred to, it should be understood as being used to distinguish technical features, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of indicated technical features or implicitly indicating the sequence of indicated technical features.

[0057] Reference Figure 1 and Figure 2 The blood component separator according to the embodiments of the present application comprises a main body 100, a squeezing mechanism 300, a mounting mechanism 200 and a mixing mechanism 400.

[0058] One side of the main body 100 has a fixed plate 110, the mounting mechanism 200 is connected to the main body 100, used to mount a blood bag (mother bag C) to be separated in front of the fixed plate 110, the mixing mechanism 400 is used to overturn the mother bag C to mix the liquid in the mother bag C, and the squeezing mechanism 300 is used to squeeze the mother bag C to make the layered blood components in the mother bag C flow out to other containers (such as a sub-bag for collecting blood components) through the pipeline connected with the mother bag C to realize component separation.

[0059] The squeezing mechanism 300 comprises a moving plate 310 and a squeezing driving assembly 320, the moving plate 310 is arranged opposite to the fixed plate 110, and the squeezing driving assembly 320 is connected to the main body 100 and the moving plate 310, used to drive the moving plate 310 to move to approach or move away from the fixed plate 110. The mixing mechanism 400 comprises a tray 410 and a mixing driving assembly 420, the mixing driving assembly 420 is connected to the main body 100 and the tray 410, used to drive the tray 410 to rotate between a first position and a second position.

[0060] When the tray 410 is in the first position, the tray 410 is located between the moving plate 310 and the fixed plate 110 and below the mounting mechanism 200, the mounting mechanism 200 is at least partially located on the side of the tray 410 away from the fixed plate 110, used for hanging a blood bag (such as the mother bag C in the figure, hereinafter the mother bag C is taken as an example for description), so that the mother bag C is hung between the tray 410 and the moving plate 310, and then the moving plate 310 is moved towards the tray 410 to contact the mother bag C, and then the moving plate 310 is continuously moved to squeeze the mother bag C for separation operation.

[0061] When the tray 410 is in the second position, the tray 410 is at least partially rotated to a position higher than the mounting mechanism 200, so that the bottom of the blood bag (such as the mother bag C in the figure, hereinafter the mother bag C is taken as an example for description) is turned to above the hanging position, and the liquid in the mother bag C can be mixed by turning, without the need to take the mother bag C from the mounting mechanism 200, simplifying the manual operation. Rotating the tray 410 multiple times can accelerate the mixing, improve the mixing efficiency and quality. The rotation angle and frequency of the tray 410 can be adjusted according to the mixing requirements to ensure uniform distribution of blood components and preservative solution.

[0062] After the mother bag C is squeezed and separated, the mother bag C is injected with preservative solution or other liquid, and then the tray 410 is turned to mix the remaining components in the mother bag C with the newly added liquid. After the mixing operation, the tray 410 can be turned back to the first position, and the mother bag C can be conveniently taken out for storage, or the mother bag C can be continuously squeezed to pack the mixed blood components into other blood bags, or the mother bag C can be vented, without the need for multiple manual operations to take and place the mother bag C. The mother bag C can be on-line squeezed, separated, injected, mixed, and then squeezed and packed or vented, ensuring the continuity of the operation, not only improving the processing efficiency, but also reducing the adverse effects of mounting position errors and mixing differences caused by manual intervention on the separation effect.

[0063] Therefore, by optimizing the cooperative work of each mechanism, the blood component separation machine of the embodiment of the application not only ensures the separation effect, but also significantly improves the operation convenience and work efficiency. The mixing mechanism 400 is integrated to turn the liquid, avoiding frequent manual taking and hanging of the bag, reducing the operation error, and effectively improving the processing speed and consistency.

[0064] Reference Figure 3In some embodiments, the outer side of the fixed plate 110 is spaced apart in the vertical direction by a plurality of sensors 500. The detection end of the sensor 500 faces the moving plate 310, and the sensor 500 is used to detect the stratification surface of the blood components in the mother bag C. The stratification surface position can be detected by a photoelectric sensor. Different color objects have different light transmittances, and the photoelectric sensor can sense the target to be detected by detecting the light value of the reflected light. For example, after the blood in the mother bag C is centrifuged and separated, different blood components are stratified, and different blood components have different light transmittances. For example, the plasma and red blood cells are stratified and have different light transmittances, so that the photoelectric sensor can determine the blood components by detecting the light value of the reflected light, thereby detecting the position of the stratification surface. The tray 410 is provided with a first avoiding opening 411 penetrating through both sides of the tray 410. When the tray 410 is located at the first position, the first avoiding opening 411 corresponds to the sensor 500, that is, the first avoiding opening 411 is located in front of the sensor 500, so as to form an avoiding between the sensor 500 and the mother bag C. During the extrusion of the mother bag C, the surface of the mother bag C is attached to the tray 410, and the sensor 500 is used to detect the stratification surface of the remaining blood components in the blood bag through the first avoiding opening 411.

[0065] Reference Figures 1 to 3 For example, taking the stratification of the upper and lower components in the mother bag C as an example, during the extrusion of the mother bag C, the upper component is extruded from the connecting pipe above the mother bag C. As the extrusion proceeds, the internal volume of the mother bag C is compressed, so that the stratification surface of the lower component and the upper component gradually moves upward, and thus can be detected by part of the plurality of sensors 500 spaced apart in the vertical direction. When the stratification surface is moved to the sensor 500 corresponding to the top position or slightly lower position of the inner cavity of the mother bag C, it can be confirmed that the separation of the upper component is basically completed, that is, the backward movement of the moving plate 310 is stopped to stop the extrusion, so as to avoid mixing with the lower component and ensure the separation effect. Alternatively, a connecting pipe can be connected to the bottom of the mother bag C to lead out the lower component during the extrusion. As the extrusion proceeds, the internal volume of the mother bag C is compressed, so that the stratification surface of the lower component and the upper component gradually moves downward, and thus can be detected by part of the plurality of sensors 500 spaced apart in the vertical direction. When the stratification surface is moved to the sensor 500 corresponding to the bottom position or slightly higher position of the inner cavity of the mother bag C, it can be confirmed that the separation of the lower component is basically completed, that is, the backward movement of the moving plate 310 is stopped to stop the extrusion, so as to avoid mixing with the upper component and ensure the separation effect.

[0066] By accurately controlling the displacement of the moving plate 310 and the real-time monitoring of the sensor 500, the sensor 500 is spaced apart in the vertical direction, so as to ensure that the stratification surface movement is sensed in time, avoid mixing with the lower component, and make the separation process more efficient and accurate.

[0067] Reference Figure 3In some embodiments, the fixed plate 110 is a side wall of the main body 100, and the fixed plate 110 has a receiving groove 112 for accommodating the sensor 500. The sensor 500 is accommodated in the receiving groove 112 and fixedly connected to the fixed plate 110. The sensor 500 can be connected to the fixed plate 110 by commonly used fixing methods such as adhesive, screw connection, clamping, or the sensor 500 and the fixed plate 110 are formed as an integrated structure.

[0068] Alternatively, referring to Figure 2 、 Figure 3 and Figure 5 In other embodiments, the main body 100 includes a cabinet 120, and the fixed plate 110 is fixed to one side of the cabinet 120, and the sensor 500 is arranged on the side of the cabinet 120 facing the fixed plate 110. The fixed plate 110 is provided with a second avoiding opening 111 corresponding to the position of the sensor 500, for avoiding the sensor 500. When the tray 410 is located at the first position, the first avoiding opening 411 and the second avoiding opening 111 correspond to the sensor 500, that is, the second avoiding opening 111 is located in front of the sensor 500, and the first avoiding opening 411 is located in front of the second avoiding opening 111, so as to form an avoiding between the sensor 500 and the mother bag C. The mother bag C is pressed against the surface of the tray 410 during the pressing process, and the sensor 500 is used to detect the stratification surface of the blood component remaining in the blood bag through the first avoiding opening 411 and the second avoiding opening 111.

[0069] Referring to Figures 1 to 3 In some embodiments, the tray 410 has opposite first and second pressing surfaces 412 and 413. When the tray 410 is located at the first position: the first pressing surface 412 abuts against the fixed plate 110, and during the pressing process, the fixed plate 110 abuts against the first pressing surface 412 to keep the tray 410 stable during the pressing of the mother bag C, so as to ensure that the mother bag C remains stable during the pressing process and avoid affecting the separation effect due to shaking. The second pressing surface 413 faces the moving plate 310 and is arranged in parallel with the moving plate 310, and is used to abut against one side of the outer wall of the blood bag. During the pressing process, one side of the mother bag C abuts against the second pressing surface 413, and the moving plate 310 abuts against the other side of the mother bag C to be pressed, so that the blood bag is uniformly stressed during the pressing process, and the separation effect is ensured.

[0070] Referring to Figure 2 and Figure 4In some embodiments, when the tray 410 is in the second position, the second pressing surface 413 has an included angle a with the fixed plate 110, the included angle a is obtuse, when the tray 410 rotates from the first position to the second position, the female bag C mounted on the mounting mechanism 200 can be lifted to overturn the bottom of the female bag C to a position higher than the hanging position, so that the liquid and the sediment in the bottom of the female bag C are redistributed under the action of gravity, and the tray 410 is driven to rotate back and forth between the first position and the second position, so as to mix the contents of the female bag C, without the need for manual taking and placing the female bag C, which is beneficial to improve the operation efficiency, and by reasonably configuring the rotation speed and angle of the tray 410, the mixing efficiency and consistency can be effectively guaranteed.

[0071] The included angle a can be in the range of 120° to 170°, for example, it can be 120°, 125°, 130°, 135°, 140°, 145°, 150°, 155°, 160°, 165°, 170° or any other value between 120° and 170°, and in some examples, the included angle a is preferably 160°, which can make the tray 410 repeatedly overturn between 0° and 160° to drive the liquid in the female bag C to mix upward and downward. The specific selection of the included angle is determined according to the separation effect and the structure of the device, so as to ensure smooth flow of the liquid during mixing, reduce residue at the bottom of the female bag C, mix the ingredients evenly, and improve the separation efficiency.

[0072] Reference Figure 3 and Figure 5 In some embodiments, the upper end of the tray 410 is provided with a notch 414 corresponding to the position of the mounting mechanism 200, which is used to avoid the mounting mechanism 200 during the overturning process of the tray 410, and also provides a deformation space for the adaptive deformation of the female bag C during the overturning process of the tray 410, effectively avoiding the problems of extrusion and jamming between the mounting mechanism 200 and the tray 410 at the position of the female bag C for suspension, and reducing the damage to the position of the female bag C for suspension.

[0073] Reference Figure 3 and Figure 5In some embodiments, the notch 414 on the tray 410 is located above the first avoiding port 411, and when the tray 410 is in the first position, the notch 414 on the upper end of the tray 410 corresponds to the upper region of the fixed plate 110, so as to avoid the sensors 500 distributed in the region. During the separation process, when the layered surface of the blood components rises to the region corresponding to the notch 414, the sensor 500 can detect the layered surface of the blood components remaining in the blood bag through the notch 414. In the case of the second avoiding port 111 of the fixed plate 110, the notch 414 of the tray 410 is opposite to the upper part of the second avoiding port 111, and the female bag C is attached to the surface of the tray 410 during the extrusion process. When the layered surface of the blood components rises to the region corresponding to the notch 414, the sensor 500 can detect the layered surface of the blood components remaining in the blood bag through the notch 414 and the second avoiding port 111.

[0074] Reference Figures 3 to 5 In some embodiments, the mixing driving assembly 420 includes a mixing motor 421 and a transmission device 422. The mixing motor 421 is fixed to the main body 100, and the transmission device 422 connects the output end of the mixing motor 421 and the tray 410. The mixing motor 421 drives the tray 410 to rotate through the transmission device 422, so as to control the rotation angle and frequency of the tray 410. Through the accurate control of the mixing motor 421, the tray 410 can be flipped at a preset angle and frequency, so as to realize the uniform mixing of the liquid in the female bag C.

[0075] The transmission device 422 can adopt various forms such as gear transmission, synchronous belt transmission or chain transmission to connect the output end of the mixing motor 421 and the tray 410, so that the mixing motor 421 accurately controls the rotation angle and frequency of the tray 410 through the transmission device 422. The tray 410 can be connected with a rotating shaft 423, which is rotatably connected with the main body 100. The rotating shaft 423 is directly connected with the output end of the mixing motor 421 or connected with the output end of the mixing motor 421 through the transmission device 422 such as a synchronous belt mechanism. The tray 410 is fixedly connected with the rotating shaft 423. The mixing motor 421 drives the rotating shaft 423 to rotate, which can drive the tray 410 to flip, so as to ensure that the flipping action is stable and accurate.

[0076] In some embodiments, the main body 100 can be provided with a reserved position beside the fixed plate 110 and the mounting mechanism 200, and the mixing mechanism 400 can further comprise a transfer mechanism, which comprises a transfer motor and a carrier. The transfer motor is fixed to the reserved position of the main body 100. The carrier is movably connected to the main body 100, and the mixing motor 421 is fixed to the carrier to set the tray 410 in the reserved position. The movement of the carrier driven by the transfer motor can make the tray 410 move between the reserved position and a predetermined position between the moving plate 310 and the fixed plate 110, so as to enter and exit between the moving plate 310 and the fixed plate 110. When the carrier is driven by the transfer motor to move the tray 410 from the reserved position to the predetermined position between the fixed plate 110, the tray 410 can be flipped between the first position and the second position by the mixing motor 421; by driving the carrier to move the tray 410 out of the predetermined position, i.e., from between the moving plate 310 and the fixed plate 110 to the reserved position, the moving plate 310 and the female bag C can be avoided.

[0077] In use, after the female bag C is separated by extrusion once, the tray 410 can be moved from the reserved position to the predetermined position between the moving plate 310 and the fixed plate 110 by driving the carrier to move by the transfer motor during the liquid injection process, the moving plate 310 is retracted, and then the tray 410 is flipped between the first position and the second position by the mixing motor 421, so that the female bag C is mixed; after the mixing is completed, the tray 410 can be moved from the predetermined position between the moving plate 310 and the fixed plate 110 to the reserved position by driving the carrier to move by the transfer motor again, to ensure that the tray 410 is reset smoothly, and then the next extrusion separation operation is performed, and the female bag C is extruded between the fixed plate 110 and the moving plate 310.

[0078] Reference Figure 1 , Figure 6 and Figure 7 In some embodiments, the mounting mechanism 200 can comprise a connecting piece 210, a hanging needle assembly 220, and a linkage assembly 230.

[0079] The connecting piece 210 is movably connected to the main body 100 in the first direction. One side of the connecting piece 210 is provided with a first inclined surface 211 inclined forward and downward in the first direction, and the connecting piece 210 is provided with an abutting portion 212 at the rear side of the first inclined surface 211. The hanging needle assembly 220 is connected to the connecting piece 210 and extends forward in the first direction, and the hanging needle assembly 220 is located above the fixed plate 110 for mounting the blood bag. The linkage assembly 230 is connected to the extrusion driving assembly 320 and the connecting piece 210, and the linkage assembly 230 is driven by the extrusion driving assembly 320 and moves with the moving plate 310.

[0080] When the moving plate 310 is located at the initial position A, the linkage assembly 230 abuts against the first inclined surface 211 to limit the rearward movement of the connecting piece 210; when the moving plate 310 moves forward of the initial position A, the linkage assembly 230 keeps abutting against the first inclined surface 211; when the moving plate 310 moves rearward of the initial position A, the linkage assembly 230 abuts against the abutting portion 212 at a set position to drive the connecting piece 210 to move rearward. Thus, the movement of the needle hanging assembly 220 and the moving plate 310 is linked, which can effectively ensure that the blood bag always maintains a suitable hanging state during the separation process, and avoid problems such as that the tray 410 is flipped and the mother bag C is separated from the needle hanging assembly 220, or that the position of the mother bag C affects the detection accuracy.

[0081] The extrusion driving assembly 320 can include an extrusion motor 321, a synchronous belt mechanism 322, a driving shaft (not shown in the figure) and a driving piece 324. The extrusion motor 321 drives the driving shaft 323 to rotate through the synchronous belt mechanism 322, thereby driving the driving piece 324 to move. The driving shaft and the driving piece 324 can be connected by threads, thereby forming a screw drive structure. The moving plate 310 and the follower 232 are connected to the driving piece 324, thereby being driven to move.

[0082] Reference Figure 1 , Figure 6 and Figure 7 In some embodiments, one side of the connecting piece 210 is provided with a first inclined surface 211, which is inclined forward and downward along a first direction. The rear side of the connecting piece 210 is provided with an abutting portion 212. When the moving plate 310 is located at the initial position A, the linkage assembly 230 abuts against the first inclined surface 211 to limit the rearward movement of the connecting piece 210, so that the position of the connecting piece 210 and the needle hanging assembly 220 is fixed. The extrusion driving assembly 320 drives the moving plate 310 to move forward of the initial position A, and the linkage assembly 230 keeps abutting against the first inclined surface 211, so that the position of the connecting piece 210 and the needle hanging assembly 220 is fixed. When the extrusion driving assembly 320 drives the moving plate 310 to move rearward of the initial position A, the linkage assembly 230 abuts against the abutting portion 212 at a set position to drive the connecting piece 210 to move rearward, so that the needle hanging assembly 220 moves rearward. When the extrusion driving assembly 320 drives the moving plate 310 to move forward of the initial position A, the linkage assembly 230 abuts against the first inclined surface 211 to drive the connecting piece 210 to move forward, so that the needle hanging assembly 220 moves forward to return to the original position. Thus, the needle hanging assembly 220 can have multiple action requirements such as keeping the position fixed, moving rearward and moving forward to return to the original position according to the movement of the follower 232. The linkage assembly 230 keeps abutting against the first inclined surface 211 to keep the position of the needle hanging assembly 220 stable, which can effectively ensure that the position of the mother bag C is stable during the flipping of the tray 410, and avoid that the mother bag C is separated from the needle hanging assembly 220.

[0083] Reference Figure 1 、 Figure 6 and Figure 7 In some embodiments, the linkage assembly 230 can include a guide 231 and a follower 232. The guide 231 is arranged on one side of the connecting piece 210 having the first slope 211, and is fixedly connected with the main body 100. The guide 231 is provided with a first guide groove 2311 and a second guide groove 2312. The first guide groove 2311 is consistent with the inclination direction of the first slope 211, and the second guide groove 2312 is communicated with the first guide groove 2311 and is arranged extending backward along the first direction. The follower 232 is arranged between the guide 231 and the connecting piece 210, and is movably connected with the extrusion driving assembly 320 along the vertical direction. The extrusion driving assembly 320 drives the follower 232 to move along the first guide groove 2311 to have a first stroke 232a, and to move along the second guide groove 2312 to have a second stroke 232b.

[0084] Wherein, the moving plate 310 is located at the initial position A, and the upper end of the follower 232 abuts against the first slope 211 to limit the backward movement of the connecting piece 210; the extrusion driving assembly 320 drives the moving plate 310 to move forward of the initial position A while driving the follower 232 to move along the first stroke 232a, and the follower 232 abuts against and slides along the first slope 211 in the first stroke 232a to limit the forward and backward positions of the connecting piece 210; the extrusion driving assembly 320 drives the moving plate 310 to move backward of the initial position A while driving the follower 232 to move along the second stroke 232b, and the follower 232 abuts against the abutting portion 212 when moving backward at the set position of the second stroke 232b to drive the connecting piece 210 to move backward. Therefore, when the extrusion driving assembly 320 drives the moving plate 310 to move, the follower 232 moves accordingly to drive the needle hanging assembly 220 to realize the action requirements of fixing the position, adjusting the backward movement, and moving forward to reset, etc. Therefore, the stroke of the follower 232 can be linked with the movement of the moving plate 310 to ensure that the needle hanging assembly 220 is adaptively adjusted in position, and to ensure the convenience of hanging the blood bag and the accuracy of separating the blood components.

[0085] While the moving plate 310 moves backward to extrude the mother bag C from the initial position A, the follower 232 moves backward at the second stroke 232b to push the connecting piece 210 and the needle hanging assembly 220 to move backward, which on the one hand ensures that the mother bag C and the needle hanging assembly 220 are adaptively moved backward with the extrusion, and the stress is uniform in the separation process, and on the other hand ensures that the rear side of the mother bag C is kept in close contact with the fixed plate 110 and the sensor 500, and ensures that the sensor 500 accurately detects the layered surface of the blood, thereby ensuring the continuity and accuracy of the separation process.

[0086] Reference Figure 1 、 Figure 6And Figure 7 In the mounting mechanism 200 of some embodiments, the guide 231 can be provided with a guide groove to limit or guide the movement of the follower 232. For example, the guide 231 is provided with a first guide groove 2311 for guiding the follower 232 to slide in the first stroke 232a, and a second guide groove 2312 for guiding the follower 232 to move in the second stroke 232b. The first guide groove 2311 is consistent with the inclination direction of the first inclined surface 211, and the second guide groove 2312 is connected to the first guide groove 2311 and extends backward in the first direction. The follower 232 moves along the first guide groove 2311 in the first stroke 232a, and moves along the second guide groove 2312 in the second stroke 232b.

[0087] During operation, when the follower 232 slides along the first guide groove 2311, its movement trajectory is constrained by the groove type, ensuring close contact with the first inclined surface 211. When the follower 232 moves along the second guide groove 2312, the groove design ensures that it accurately avoids contact with the first inclined surface 211, and can abut the abutting portion 212 during backward movement to drive the hanger pin assembly 220 to move backward, achieving smooth backward movement of the connecting piece 210 and the hanger pin assembly 220, avoiding interference with the backward movement of the hanger pin assembly 220, and during the process of the follower 232 moving forward from the rear end along the second guide groove 2312, it can again contact the first inclined surface 211 to drive the connecting piece 210 and the hanger pin assembly 220 to move forward and return to the original position B. Ensure that the follower 232 can accurately abut the corresponding part in both strokes, further optimizing the stability and adjustment accuracy of the hanger pin assembly 220.

[0088] The upper end of the follower 232 can be provided with a second inclined surface 2321 parallel to the first inclined surface 211, thereby forming a structure that fits with the first inclined surface 211. In the first stroke 232a, the second inclined surface 2321 contacts and abuts the first inclined surface 211, thereby interacting with the parallel inclined surfaces to generate a stable forward component force of the follower 232 on the connecting piece 210, improving the position stability of the hanger pin assembly 220, and effectively ensuring the position stability of the mother bag C during the turnover of the tray 410.

[0089] Reference Figure 1 、 Figure 6 And Figure 7In some embodiments, the follower 232 is provided with a guide portion 2322 on the side facing the guide 231, which can slide or roll along the first guide groove 2311 and the second guide groove 2312. For example, the guide portion 2322 can be designed as a boss protruding from the side of the follower 232 facing the guide 231, which is fitted with the inner wall of the guide groove (i.e. the first guide groove 2311 and the second guide groove 2312), and the boss can be cylindrical, elliptical cylindrical or prismatic; or the guide portion 2322 can also be designed as a roller matched with the inner wall of the guide groove, and the follower 232 is provided with a connecting shaft for mounting the roller, which rolls in the first guide groove 2311 and the second guide groove 2312, which can reduce the frictional resistance, ensure the flexible movement of the follower 232, and reduce the jamming.

[0090] Referring to Figure 6 , Figure 7 and Figure 1 In some embodiments, the side of the follower 232 facing away from the guide 231 is provided with a sliding portion extending in the vertical direction, and the follower 232 is driven to move in the vertical direction relative to the guide 231 through the sliding portion. Therefore, when the follower 232 moves forward in the first stroke 232a, the top of the follower 232 abuts against the first inclined surface 211, and the first inclined surface 211 has a downward reaction force on the follower 232, which moves the follower 232 forward along the first inclined surface 211 while moving downward relative to the guide 231 through the sliding portion, thereby ensuring stable abutment with the first inclined surface 211, and during the backward movement of the follower 232 in the first stroke 232a, the first guide groove 2311 has an upward supporting force on the follower 232, which moves the follower 232 backward along the first inclined surface 211 while moving upward relative to the guide 231 through the sliding portion, ensuring continuous and stable contact with the first inclined surface 211, so as to maintain a suitable mounting position during the liquid injection process of the mother bag C and the overturning and mixing process of the tray 410.

[0091] The sliding portion can include a matched slider and slide rail structure, one of the slider and the slide rail is connected to the follower 232, and the other is adapted to be connected to the extrusion driving assembly 320 for driving the movement of the moving plate 310, the slide rail has a track extending in the vertical direction, and the slider is tightly fitted with the slide rail to ensure smooth movement of the sliding portion in the vertical direction, and the extrusion driving assembly 320 drives the moving plate 310 and the sliding portion to move in the first direction to make the follower 232 move together with the moving plate 310.

[0092] The follower 232 moves backward into the second stroke 232b and disengages from the abutment with the first slope 211 in the first stroke 232a, and then continues to move backward to abut against and move backward with the abutment portion 212, so that the connecting piece 210 and the needle assembly 220 move stably backward. In the second stroke 232b, the follower 232 moves along the second guide groove 2312, which defines the movement track of the follower 232 as moving in the first direction, so that the follower 232 does not move up and down due to sliding, and ensures that the follower 232 moves stably in the second stroke 232b.

[0093] With reference to Figure 6 and Figure 7 In some embodiments, the first slope 211 of the connecting piece 210 is partially in the range of the second stroke 232b, i.e., the first slope 211 is partially above the second guide groove 2312, or the part of the first slope 211 is moved above the second guide groove 2312 when the follower 232 moves backward in the second stroke 232b to move the abutment portion 212 backward. Therefore, the follower 232 can re-abut against the first slope 211 after moving forward for a certain distance at the rear end of the second stroke 232b, so as to push the connecting piece 210 and the needle assembly 220 to move stably forward in the first direction until completely reset. In this process, the follower 232 cooperates with the second guide groove 2312 so as not to slide downward, and ensures that the connecting piece 210 and the needle assembly 220 remain stable during the resetting process.

[0094] In addition, with reference to Figure 1 , Figure 6 and Figure 7 During the process that the follower 232 re-abuts against the first slope 211 and pushes the connecting piece 210 and the needle assembly 220 to reset, the reaction force of the first slope 211 on the follower 232 and the movement track of the follower 232 in the second guide groove 2312 are mutually coordinated, so that the follower 232 can move stably and accurately along the predetermined path to reset, so as to reset the needle assembly 220, so as to maintain a suitable hanging position during the liquid injection process of the mother bag C and the overturning and mixing process of the tray 410.

[0095] With reference to Figure 1 , Figure 2 and Figure 6In some embodiments, the squeezing mechanism 300 further comprises another fixed plate arranged opposite to the front side of the moving plate 310 along the first direction. For the sake of convenience, the fixed plate located at the back side of the moving plate 310 is defined as the first fixed plate 330, and the fixed plate located at the front side of the moving plate 310 is defined as the second fixed plate 340. The first fixed plate 330 and the second fixed plate 340 are connected to the main body 100. The needle-hanging assembly 220 is located above the first fixed plate 330, and is used to hang the mother bag C after blood centrifugation at the front side of the first fixed plate 330. The back side of the second fixed plate 340 is used to hang the child bag. The moving plate 310 moves forward from the initial position A to move towards the child bag and squeeze the child bag. The moving plate 310 moves backward from the initial position A to move towards the mother bag C and squeeze the mother bag C, so as to ensure that the blood components are separated as required.

[0096] Reference Figure 7 、 Figure 1 、 Figure 2 and Figure 6 In some embodiments of the blood component separation machine, the hanging mechanism 200 suspends the mother bag C at the back side of the moving plate 310 and suspends another blood bag (for example, the child bag) at the front side of the moving plate 310. The hanging mechanism 200 can be connected to the squeezing driving assembly 320 through the follower 232 so as to be linked with the moving plate 310. The squeezing driving assembly 320 controls the displacement of the moving plate 310 through the preset stroke parameters, so as to synchronously adjust the position of the follower 232, and further adjust the state and position of the needle-hanging assembly 220, for example:

[0097] When the moving plate 310 is at the initial position A, the needle-hanging assembly 220 corresponds to the original position B. At this time, the follower 232 abuts against the first inclined surface 211 of the connecting piece 210, so that the needle-hanging assembly 220 keeps a stable position and cannot move backward, and the mother bag C is conveniently suspended.

[0098] During the process that the moving plate 310 moves forward to squeeze the front side blood bag and moves backward to return to the initial position A after the squeezing is completed, the follower 232 keeps in the first stroke 232a, so as to keep abutting against the first inclined surface 211, and the needle-hanging assembly 220 keeps a stable position, so that the mother bag C suspended on the needle-hanging assembly 220 keeps a stable position.

[0099] In the process of moving plate 310 extruding mother bag C (located at the rear side of moving plate 310) suspended on the needle assembly 220 from the initial position A, the follower 232 moves in the second stroke 232b, and abuts against the abutting portion 212 of the connecting piece 210 at a set position (for example, when the moving plate 310 starts to move backward or after moving a distance, which can be set according to the program) and drives the connecting piece 210 to move backward, so that the needle assembly 220 adaptively retreats, thereby ensuring that the mother bag C keeps abutting against the abutting surface located at the rear of the mother bag C in the process of extrusion. The abutting surface is provided with a sensor for detecting the height of the remaining blood components in the mother bag C. Keeping the mother bag C abutting against the abutting surface in the process of extrusion can effectively improve the accuracy of detection, thereby ensuring the separation effect.

[0100] In the process of moving plate 310 moving forward to the initial position A after completing the extrusion of the rear mother bag C, the follower 232 moves forward and abuts against the first inclined surface 211, thereby driving the connecting piece 210 and the needle assembly 220 to move forward to the original position B. At this time, the follower 232 keeps abutting against the first inclined surface 211, thereby ensuring the stability of the position of the needle assembly 220 and facilitating the liquid injection again.

[0101] After liquid injection, before mixing the mother bag C, it is necessary to ensure that the moving plate 310 is outside the turning range of the tray 410. For example, if the moving plate 310 is in the initial position A, the tray 410 can be turned without moving the moving plate 310. If the moving plate 310 needs to be moved, the moving plate 310 is adjusted to a safe position by the extrusion driving assembly 320, so as to ensure that the tray 410 is not hindered when it is turned. Then, the tray 410 is turned to mix the contents of the mother bag C by the mixing motor. After mixing, the mother bag C can be extruded again by the moving plate 310.

[0102] Therefore, the blood component separator of the embodiment of the present application adopts the hanging mechanism 200, which can not only be used for hanging the mother bag C in the blood component separator, but also can be linked with the moving plate 310 of the blood component separator through the follower 232. The linkage design can realize the stable hanging and adaptive position adjustment of the needle assembly 220 when the moving plate 310 performs different operations, thereby ensuring the stability of the hanging of the mother bag C and effectively improving the efficiency and precision of the blood component separation.

[0103] Reference Figure 1 , Figure 2 and Figure 1In some embodiments, the blood component separator further comprises a dislodging mechanism 600, which comprises two dislodging rods 610 arranged at intervals and a rotating mechanism 620 connected to the main body 100, the rotating mechanism 620 being configured to drive the dislodging rods 610 to rotate. After the mother bag C is hung on the hanging mechanism 200, the connecting plug of the mother bag C can be located between the two dislodging rods of the dislodging mechanism 600, and the dislodging mechanism 600 can rotate the dislodging rods to dislodge the connecting plug of the mother bag C to make the inner cavity of the mother bag C communicate with the pipeline.

[0104] In addition, by precisely controlling the displacement of the moving plate 310 and the real-time monitoring of the sensor 500, the separation process is more efficient and accurate. While the moving plate 310 moves backward from the initial position A to extrude the mother bag C, the follower 232 moves backward in the second stroke 232b to push the connecting piece 210 and the needle hanging assembly 220 to move backward, on the one hand, it ensures that the hanging of the mother bag C and the needle hanging assembly 220 is self-adapting to move backward with the extrusion, and the stress is uniform during the separation process, on the other hand, it makes the rear side of the mother bag C keep in contact with the first fixed plate 330 and the sensor 500, which ensures that the sensor 500 accurately detects the stratification surface of the blood, thereby ensuring the continuity and accuracy of the separation process.

[0105] Reference Figure 2 and Figures 1 to 8 In some embodiments, the main body 100 is provided with a control module and a detection module, the detection module being configured to detect at least one of the running state of the extrusion mechanism 300, the running state of the hanging mechanism 200 and the running state of the mixing mechanism 400, and the control module being communicatively connected to the extrusion mechanism 300 and the mixing mechanism 400, and being configured to control the start and stop of the extrusion mechanism 300 and the mixing mechanism 400 according to the data of the detection module.

[0106] The detection module can comprise a plurality of sensors distributed in multiple places, such as position sensors and angle sensors, which are configured to detect whether the execution components in each mechanism are at the positions planned in the preset program, and assist in confirming the running state of each mechanism. For example, the detection module can monitor the position of the moving plate 310 in the extrusion mechanism 300 through the position sensor, and when the detection module finds that the position of the moving plate 310 is abnormal, the control module can stop operation, and then output an error prompt or an alarm. The detection module can also detect the position of the needle hanging assembly 220 through the position sensor to ensure that the mother bag C always maintains the correct position during the separation process, avoiding the influence of position deviation on the separation effect. The detection module can also monitor whether the tray 410 is at the predetermined position through the position sensor, and monitor the running state of the mixing mechanism 400 through the angle sensor and the counter to detect the turning angle and the number of times of the tray 410, so as to ensure that the mixing operation can achieve the expected effect, thereby ensuring the accuracy and efficiency of the blood component separation.

[0107] In industrial automation equipment, monitoring the running state of the movement mechanism by the sensor, and controlling the start and stop of the movement mechanism according to whether the running state meets the state planned by the preset program by the control module is a widely used means in the field, and the specific control principle and method are not described here. The controller can be implemented by using a single-chip microcomputer, PLC, etc. Through the preset program logic, the blood component separation machine of the embodiment of the application can realize various action requirements of the extrusion mechanism 300, the mounting mechanism 200, and the mixing mechanism 400.

[0108] The embodiment of the application also provides a blood component separation method applied to the blood component separation machine of any one of the embodiments of the application. Figure 3 and ​ The blood component separation method comprises the following steps.

[0109] The tray 410 is located at the first position, and the centrifuged blood mother bag C is hung on the mounting mechanism 200.

[0110] The moving plate 310 is moved towards the tray 410 by the extrusion driving assembly 320 and extrudes the mother bag C, so that the first component of the blood in the mother bag C is extruded into the first separation bag D in communication with the mother bag C, and the passage between the first separation bag D and the mother bag C is stopped.

[0111] The moving plate 310 is moved to the avoiding position, the mother bag C is injected with the maintenance liquid, and the tray 410 is rotated at a preset angle and frequency for multiple times by the mixing driving assembly 420, so that the tray 410 is located at the first position.

[0112] Therefore, the extrusion separation and online mixing after liquid injection are realized by the extrusion mechanism 300 and the mixing mechanism 400, and manual mixing is not required, which is beneficial to the efficient and accurate separation of blood components.

[0113] In some embodiments, after the mixing operation, the tray 410 is located at the first position, and then the connecting pipe connected with the mother bag C is closed, and the mother bag C is taken off from the hanging needle assembly 220.

[0114] In some other embodiments, after the mixing operation, the mother bag C can be extruded again, so that the mixed blood component is sub-packed or the mother bag C is exhausted. For example, after the mixing operation, the tray 410 is located at the first position, the moving plate 310 is moved towards the tray 410 by the extrusion driving assembly 320 and extrudes the mother bag C, so that part of the mixed blood component in the mother bag C is extruded into the second separation bag E in communication with the mother bag C, thereby being sub-packed. Alternatively, after the mixing operation, the tray 410 is located at the first position, the moving plate 310 is moved towards the tray 410 by the extrusion driving assembly 320 and extrudes the mother bag C, so that the excess air in the mother bag C is exhausted.

[0115] Reference​ In the separation method of some embodiments, a quadruple blood bag is exemplified:

[0116] The quadruple blood bag can include a mother bag C and three sub-bags connected to the mother bag C, the three sub-bags are connected to a collecting pipe through a pipe respectively, the collecting pipe is connected to the mother bag C, and the three sub-bags include a first sub-bag D, a second sub-bag E and a preservative bag F. By controlling the forward and backward movement of the moving plate 310, the accurate separation of different blood components in the mother bag C is realized.

[0117] In the first stage of the extrusion process, the moving plate 310 moves backward to extrude the mother bag C, and the first blood component (such as plasma) is extruded into the first sub-bag D. Then, the passage between the first sub-bag D and the mother bag C is stopped, which can be achieved by pressing the connecting pipe between the first sub-bag D and the mother bag C with the hot melt pressure head 700. After that, the moving plate 310 retreats to the avoidance position to make room for the subsequent liquid injection and mixing operation.

[0118] In the liquid injection stage, the preservative liquid is injected into the mother bag C from the preservative bag F. The preservative bag F can be hung at the second fixed plate 340 on the front side of the moving plate 310, and the preservative liquid is injected into the mother bag C by moving the moving plate 310 forward to extrude the preservative bag F. Alternatively, the preservative bag F can be hung at other positions on the main body 100, and the preservative liquid is injected into the mother bag C by extruding the preservative bag F with other extrusion plates (such as the schematic top extrusion plate 350) on the main body 100. After the injection, the passage between the second sub-bag E and the mother bag C can be stopped, and the connecting pipe between the second sub-bag E and the mother bag C can be pressed with the hot melt pressure head 700 to prevent the second blood component from entering the preservative bag F in the subsequent secondary separation. ​

[0119] In the mixing stage, the mother bag C after the injection is mixed. After the tray 410 is driven to the first position by the mixing drive assembly 420, it is rotated multiple times at a predetermined angle and frequency, so that the preservative liquid and the remaining blood components (such as red blood cells) in the mother bag C are fully mixed, and then the tray 410 returns to the first position to prepare for the next stage of extrusion and separation.

[0120] In the second stage of the extrusion process, the moving plate 310 moves backward again to extrude the mother bag C, and the second blood component (such as red blood cells) is extruded into the second sub-bag E.

[0121] Therefore, by using the blood component separation machine and the separation method of the embodiments of the present application, online mixing after injection is realized, and no additional manual operation is required, which is conducive to the efficient and accurate separation of blood components.

[0122] ​The embodiments of the present application are described in detail above with reference to the drawings, but the present application is not limited to the above embodiments, and various changes can be made within the knowledge of those skilled in the art without departing from the spirit of the present application. In addition, the embodiments of the present application and the features in the embodiments can be combined with each other without conflict.

Claims

1. A blood component separation machine characterized by, The utility model relates to a blood bag mixing device, comprising: a main body, one side of the main body having a fixed plate; a pressing mechanism, comprising a moving plate and a pressing drive assembly, the moving plate being arranged opposite to the fixed plate, the pressing drive assembly being connected to the main body and the moving plate, for driving the moving plate to move to approach or move away from the fixed plate; a mounting mechanism connected to the main body; a mixing mechanism, comprising a tray and a mixing drive assembly, the mixing drive assembly being connected to the main body and the tray, for driving the tray to rotate between a first position and a second position; in the first position, the tray is located between the moving plate and the fixed plate and below the mounting mechanism, the mounting mechanism being at least partially located on the side of the tray away from the fixed plate, for suspending a blood bag; in the second position, the tray is at least partially rotated to a position higher than the mounting mechanism, so that the bottom of the blood bag is turned over to above the suspension position.

2. The blood component separation machine of claim 1, wherein, The outer side of the fixed plate is spaced apart in the vertical direction and provided with a plurality of sensors; The tray is provided with a first avoiding opening penetrating through both sides of the tray, when the tray is located in the first position, the first avoiding opening corresponds to the sensors, and the sensors are used for detecting the stratification surface of the remaining blood components in the blood bag through the first avoiding opening.

3. The blood component separation machine of claim 2, wherein, The main body comprises a cabinet, the fixed plate is fixed to one side of the cabinet, and the sensors are arranged on the side of the cabinet facing the fixed plate; the fixed plate is provided with a second avoiding opening corresponding to the position of the sensors, for avoiding the sensors; Alternatively, the fixed plate serves as a side wall of one side of the main body, the fixed plate has a containing groove accommodating the sensors, and the sensors are accommodated in the containing groove and fixedly connected to the fixed plate.

4. The blood component separation machine of claim 1, wherein, The tray has opposite first and second pressing surfaces; When the tray is located in the first position: the first pressing surface abuts against the fixed plate, and the second pressing surface faces the moving plate, for abutting against the side outer wall of the blood bag and being arranged in parallel with the moving plate.

5. The blood component separation machine of claim 4, wherein, When the tray is located in the second position, the second pressing surface has an included angle with the fixed plate, and the included angle is obtuse.

6. The blood component separation machine of claim 1, wherein, The upper end of the tray is provided with a notch corresponding to the position of the mounting mechanism, for avoiding the mounting mechanism during the turning over of the tray.

7. The blood component separation machine of claim 1, wherein, The mixing drive assembly comprises a mixing motor and a transmission device, the mixing motor being fixed to the main body, the transmission device connecting the output end of the mixing motor and the tray, and the mixing motor driving the tray to rotate through the transmission device, so as to control the rotation angle and frequency of the tray.

8. The blood component separation machine of claim 1, wherein, The mounting mechanism comprises: a connecting piece movably connected to the main body in the first direction, one side of the connecting piece being provided with a first inclined surface, the first inclined surface being inclined forward and downward along the first direction, and the connecting piece being provided with an abutting portion on the rear side of the first inclined surface; a hanging needle assembly connected to the connecting piece and extending forward along the first direction, the hanging needle assembly being located above the fixed plate, for suspending a blood bag; A linkage assembly is connected to the extrusion driving assembly and the connecting member, and is driven by the extrusion driving assembly and moves with the movement of the moving plate; When the moving plate is at the initial position, the linkage assembly abuts against the first inclined surface to limit the backward movement of the connecting member; when the moving plate moves forward of the initial position, the linkage assembly keeps abutting against the first inclined surface; when the moving plate moves backward of the initial position, the linkage assembly abuts against the abutting portion at a set position to drive the connecting member to move backward.

9. The blood component separation machine according to any one of claims 1 to 8, characterized in that, The main body is provided with a control module and a detection module, the detection module is used to detect at least one of the running state of the extrusion mechanism, the running state of the mounting mechanism and the running state of the mixing mechanism, the control module is communicatively connected to the extrusion mechanism and the mixing mechanism, and the control module is used to control the start and stop of the extrusion mechanism and the mixing mechanism according to the data of the detection module.

10. A method of separating blood components, characterized by, The blood component separation machine of any one of claims 1 to 9; the separation method comprises: The tray is located at the first position, and the centrifuged blood mother bag is hung on the mounting mechanism; The moving plate is moved toward the tray by the extrusion driving assembly and extrudes the mother bag to extrude the first component of the blood in the mother bag into a first separation bag in communication with the mother bag, and the passage between the first separation bag and the mother bag is cut off; The moving plate is moved to a avoiding position, the mother bag is injected with a maintenance liquid, and the tray is rotated at a preset angle and frequency for multiple times by the mixing driving assembly, and then the tray is located at the first position. The blood component separation machine of any one of claims 1 to 9; the separation method comprises: The tray is located at the first position, and the centrifuged blood mother bag is hung on the mounting mechanism; The moving plate is moved toward the tray by the extrusion driving assembly and extrudes the mother bag to extrude the first component of the blood in the mother bag into a first separation bag in communication with the mother bag, and the passage between the first separation bag and the mother bag is cut off; The moving plate is moved to a avoiding position, the mother bag is injected with a maintenance liquid, and the tray is rotated at a preset angle and frequency for multiple times by the mixing driving assembly, and then the tray is located at the first position.

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