Multi-imaging animal fixing device, tray, animal cabin and animal imaging system

Abstract

The embodiment of the invention discloses a multi-imaging animal fixing device, a tray, an animal cabin and an animal imaging system. The multi-imaging animal fixing device comprises a supporting part and trays, wherein the supporting part is configured to support the trays; and the tray is detachably connected with the supporting part. The tray comprises a first end part, the first end part is configured to place the head of an imaging animal, each tray is provided with a detachably connected marker accommodating part, the marker accommodating part is configured to accommodate a marker, and the marker can be developed in an imaging mode of at least one mode.

Description

Technical Field

[0001] This specification relates to the field of animal imaging, and in particular to a multi-imaging animal restraint device, tray, animal cabin, and animal imaging system. Background Technology

[0002] Animal experiments refer to scientific research using animals (e.g., mice) to gain new knowledge in biology, medicine, and other fields, or to solve specific problems. Some animal experiments require scanning and imaging of the animals. To ensure image quality (e.g., reducing motion artifacts), the animals need to be secured. However, existing animal fixation solutions for imaging cannot achieve standardized animal placement and are inefficient. For example, researchers often use tape to randomly fix mice to a flat surface, and typically fix the animals directly inside the animal chamber. This places high demands on the animal chamber itself and cannot meet the needs of animal experiments. Existing animal chambers are mostly customized products based on scanning equipment, which cannot meet diverse experimental requirements. Furthermore, the structure of the animal chamber and its fixation devices are provided by the manufacturer, making them unsuitable for different users' varying experimental needs, resulting in low experimental efficiency. Summary of the Invention

[0003] This specification provides one or more embodiments of a multi-imaging animal restraint device, the multi-imaging animal restraint device comprising: a support portion and a plurality of trays, the support portion being configured to support the plurality of trays; the trays being detachably connected to the support portion, the trays including a first end portion being configured to place the head of an imaging animal, each of the trays having a detachably connected marker receiving portion being configured to receive a marker, the marker being developable in at least one imaging modality.

[0004] In some embodiments, the tray includes a second end portion disposed opposite to the first end portion, and the support portion includes a first portion and a second portion disposed opposite to each other; the first portion is configured to support the first end portion of the tray; the second portion is configured to support the second end portion of the tray; the support portion further includes a third portion between the first portion and the second portion, the third portion having a cutout portion.

[0005] In some embodiments, an anesthesia port is provided on the first end, the anesthesia port being configured to deliver anesthetic gas to the imaging animal; a dental rod is also provided on the first end for the occlusal fixation of the imaging animal's teeth.

[0006] In some embodiments, the support is configured to support 2-4 trays.

[0007] In some embodiments, the tray has a first hole structure and a second hole structure that penetrate the tray. The first hole structure includes two through holes configured for the two forelimbs of the imaging animal to pass through, and the second hole structure includes two through holes configured for the two hindlimbs of the imaging animal to pass through.

[0008] In some embodiments, the through hole is a waist-shaped hole.

[0009] In some embodiments, the tray is provided with a fixing structure, the fixing structure having multiple components, and the multiple marker receiving portions are detachably mounted to the tray via the fixing structure.

[0010] In some embodiments, the fixing structure is a retaining ring structure, which includes a resilient retaining ring arm configured to fix the marker receiving portion.

[0011] In some embodiments, the marker receiving portion includes a first receiving channel, a second receiving channel, and a marker receiving cavity. The first receiving channel is configured to inject the marker, the second receiving channel is configured to discharge gas when the marker is injected, and the marker receiving cavity is connected to the first receiving channel and the second receiving channel respectively, and is configured to receive the marker.

[0012] In some embodiments, the first receiving channel is cylindrical and the marker receiving cavity is spherical, with the center of the marker receiving cavity located on the central axis of the first receiving channel.

[0013] In some embodiments, the marker is a liquid, the marker is developable in at least one first mode of imaging, and the marker receiving portion is developable in at least one second mode of imaging; the first mode includes at least one of positron emission tomography, single-photon emission imaging, or magnetic resonance imaging, and the second mode includes X-ray imaging.

[0014] In some embodiments, the marker receiving portion is 3D printed; the diameter of the first receiving channel is larger than that of the second receiving channel.

[0015] In some embodiments, the first portion is provided with a marker for placing the head of the imaging animal.

[0016] In some embodiments, the support includes a first portion configured to support a first end of the tray, the first portion being provided with a snap-fit ​​structure configured to snap into the first end of the tray; the snap-fit ​​structure includes an outwardly protruding snap-fit ​​boss, and the anesthesia interface is provided with an inwardly recessed snap-fit ​​structure, the snap-fit ​​boss being configured to embed into the snap-fit ​​structure to achieve snap-fit ​​between the anesthesia interface and the snap-fit ​​structure.

[0017] In some embodiments, the anesthesia interface includes a first anesthesia channel and a second anesthesia channel. The first anesthesia channel includes a first end and a second end, and the second anesthesia channel includes a third end and a fourth end. The first end is the inlet of the anesthetic gas, and the third end is the outlet of the anesthetic gas and is located near the nose of the imaging animal. The second end is connected to the fourth end, and at the connection point, there is a preset angle between the second end and the fourth end.

[0018] This specification provides one or more embodiments of a tray for securing an imaging animal, the tray being configured to accommodate a single imaging animal, the tray including a first end and a second end, the first end being configured to secure the head of the imaging animal, and the second end being disposed opposite to the first end; the tray being detachably connected to a support portion of a multi-imaging animal securing device, the multi-imaging animal securing device being detachably placed within an animal chamber; the tray having a detachably connected marker receiving portion configured to accommodate a marker that is developable in at least one imaging modality.

[0019] This specification provides one or more embodiments of an animal cabin, the animal cabin including a cabin body; and a multi-image animal restraint device as described in any of the above embodiments, the multi-image animal restraint device being detachably placed within the cabin body.

[0020] This specification provides one or more embodiments of an animal imaging system, the animal imaging system including a scanning imaging device having a scanning cavity; and a multi-imaging animal restraint device as described in any of the above embodiments, the multi-imaging animal restraint device being able to enter the scanning cavity; or an animal cabin as described in any of the above embodiments, the animal cabin being able to enter the scanning cavity.

[0021] In some embodiments, the scanning imaging device is one of a computed tomography (CT) device, a magnetic resonance imaging (MRI) device, a positron emission tomography (PET) device, and a single-photon emission tomography (SPECT) device, or a multimodal imaging device that combines multiple of these devices.

[0022] This specification provides a multi-imaging animal restraint device, a tray, an animal chamber, and an animal imaging system. The multi-imaging animal restraint device enables multiple imaging animals (e.g., multiple mice) to be scanned simultaneously in a standardized position. Using the tray, multimodal image templates can be created, thereby establishing a multimodal image database. The animal chamber includes either the tray or the multi-imaging animal restraint device; the number of imaging animal restraint devices within the animal chamber can be flexibly adjusted according to needs, maximizing the utilization of the internal space of the animal chamber. Attached Figure Description

[0023] This specification will be further described by way of exemplary embodiments, which will be described in detail with reference to the accompanying drawings. These embodiments are not limiting; in these embodiments, the same reference numerals denote the same structures, wherein:

[0024] Figure 1 This is a schematic diagram of the structure of a tray for a multi-imaging animal restraint device according to some embodiments of this specification;

[0025] Figure 2 This is a schematic diagram of a dual-layer multi-imaging animal restraint device according to some embodiments of this specification;

[0026] Figure 3 This is a structural schematic diagram of the animal compartment according to some embodiments shown in this specification;

[0027] Figure 4A This is a schematic diagram of the structure of another tray for a multi-image animal restraint device, as shown in some embodiments of this specification;

[0028] Figure 4B This is an enlarged structural schematic diagram of region I of the tray for a multi-imaging animal restraint device, as shown in some embodiments of this specification;

[0029] Figure 5 This is a schematic diagram of the anesthesia interface shown in some embodiments of this specification;

[0030] Figure 6A and 6B This is a schematic diagram of the structure of the marker receiving portion according to some embodiments of this specification;

[0031] Figure 7A This is a schematic diagram of the structure of the support portion of the multi-imaging animal fixation device according to some embodiments of this specification;

[0032] Figure 7B This is an enlarged structural schematic diagram of region II of the support portion shown in some embodiments of this specification;

[0033] Figure 8A This is a structural schematic diagram of yet another double-layered multi-imaging animal restraint device according to some embodiments of this specification;

[0034] Figure 8B This is an enlarged structural schematic diagram of region III according to some embodiments of this specification;

[0035] Figure 9 This is a cross-sectional structural schematic diagram of a multi-imaging animal restraint device according to some embodiments of this specification;

[0036] Figure 10 This is a structural schematic diagram of yet another animal cabin shown according to some embodiments of this specification.

[0037] Reference numerals: 10-Single-image animal restraint device; 20-Multi-image animal restraint device; 30-Animal chamber; 40-Single-image animal restraint device; 60-Tag container; 70-Multi-image animal restraint device; 1000-Animal chamber; 100-Tray; 110-Head restraint; 111-Head cap; 112-Tooth bar; 120-Forelimb restraint; 130-Hhind limb restraint; 140-Tail restraint; 150-First tag container; 160-Second tag container; 210-First part; 220-Second part; 230-Third part; 300-Bed body; 400-Tray; 410-First end; 411-Anesthesia interface; 411-1-First Anesthesia channel; 411-1A-First end; 411-1B-Second end; 411-2-Second anesthesia channel; 411-2A-Third end; 411-2B-Fourth end; 411-3-Snap-fit ​​structure; 420-Second end; 430-First hole structure; 440-Second hole structure; 450-Fixing structure; 451-Snap-fit ​​arm; 460-Snap-fit ​​groove; 610-First receiving channel; 620-Marker receiving cavity; 630-Second receiving channel; 640-Shaft; 700-Support part; 710-First part; 711-Marker; 712-Snap-fit ​​structure; 712-1-Snap-fit ​​boss; 720-Second part; 721-Snap-fit ​​groove structure; 730-Third part. Detailed Implementation

[0038] Exemplary embodiments or implementations will now be described in detail, examples of which are illustrated in the accompanying drawings. When the following description relates to the drawings, unless otherwise indicated, the same numbers in different drawings denote the same or similar elements. The implementations described in the following exemplary embodiments do not represent all implementations consistent with this specification. Rather, they are merely examples of apparatuses and methods consistent with some aspects of this specification as detailed in the appended claims.

[0039] The terminology used in this specification is for the purpose of describing particular embodiments only and is not intended to be limiting of this specification. The singular forms “a,” “the,” and “the” as used in this specification and the appended claims are also intended to include the plural forms unless the context clearly indicates otherwise.

[0040] It should be understood that the terms "first," "second," and similar terms used in this specification and claims do not indicate any order, quantity, or importance, but are merely used to distinguish different components. Similarly, the terms "an" or "a" and similar terms do not indicate a quantity limitation, but rather indicate the presence of at least one. Unless otherwise stated, the terms "front," "rear," "lower," and / or "upper" and similar terms are for illustrative purposes only and are not limited to a location or spatial orientation. The terms "comprising" or "including" and similar terms mean that the elements or objects preceding "comprising" or "including" encompass the elements or objects listed following "comprising" or "including" and their equivalents, but do not exclude other elements or objects.

[0041] It should be noted that although the embodiments in this specification are mainly illustrated using mice (e.g., mice, rats), the fixation devices provided in the embodiments of this specification can also be applied to the fixation of other imaging animals, especially small mammals, such as guinea pigs, hamsters, bamboo rats, weasels, rabbits, etc.

[0042] This specification provides a multi-imaging animal restraint device in some embodiments, see reference. Figure 8A The multi-image animal restraint device 70 includes a support 700 and a plurality of trays 400, wherein the support 700 is configured to support the plurality of trays 400; the trays 400 are detachably connected to the support 700.

[0043] refer to Figure 4A The tray 400 includes a first end 410 configured to hold the head of an imaging animal. Each tray 400 has a detachably connected marker receiving portion configured to hold a marker that is developable in at least one imaging modality.

[0044] The support is configured to support multiple trays. In some embodiments, the support has multiple tray positions. In some embodiments, the number of tray positions is 2-4. Each tray position can connect to one tray. In some embodiments, the number of tray positions is 2, 3, or 4. In a single experiment, the number of trays can be less than or equal to the number of tray positions. For example, if the number of tray positions is 4, the number of trays that can be connected can be 1-4. This is just an example. Figure 8A As shown, the four trays 400 are connected together by the support 700.

[0045] Figure 1 This is a schematic diagram of the structure of a tray for a multi-image animal restraint device, as shown in some embodiments of this specification.

[0046] like Figure 1 As shown, each tray 100 can be used to accommodate a single imaging animal, and each tray 100 can constitute a single imaging animal restraint device 10. The tray 100 is provided with a head restraint part 110, a forelimb restraint part 120, a hindlimb restraint part 130, and a tail restraint part 140. In some embodiments, the end of the tray 100 where the head restraint part 110 is located is referred to as the first end, and the end where the tail restraint part 140 is located is referred to as the second end.

[0047] A head-fixing part 110 is used to fix the head of the imaging animal. In some embodiments, the head-fixing part 110 may include a head cap 111 and a tooth bar 112. The head cap 111 is a sleeve-like structure for accommodating the head of the imaging animal, and the tooth bar 112 is a rod-like structure for fixing the teeth of the imaging animal (e.g., rods such as mice and rabbits). The tooth bar 112 has an opening (e.g., a circular or other shaped opening) to hook onto the teeth of the imaging animal (e.g., rods such as mice and rabbits). In some embodiments, the head-fixing part 110 may include an ear bar (not shown), which is a rod-like structure that can fix the head of the imaging animal by inserting the ear bar into the ear canal of the imaging animal and pressing it against the skull of the imaging animal. The head-fixing part 110 may include two ear bars, one ear bar for inserting into the left ear canal of the imaging animal and the other ear bar for inserting into the right ear canal of the imaging animal.

[0048] The forelimb fixation part 120 is used to fix the forelimb of the imaging animal.

[0049] like Figure 1 As shown, the forelimb fixing part 120 can be designed as a groove structure, which provides ample operating space, making it convenient for the operator to fix the forelimb of the imaging animal to or remove it from the forelimb fixing part 120.

[0050] In some embodiments, the forelimb fixation portion can also be designed as other structures (such as...). Figure 4A For example, the forelimb fixation part can be designed as a perforated structure with a cavity that extends through it. After the forelimb of the imaging animal is inserted into the cavity of the forelimb fixation part, it can be effectively fixed under the constraint of the cavity. The perforated structure not only makes it easier to fix the animal's forelimb but also avoids compressing it, making subsequent imaging areas easier to distinguish and resulting in better imaging effects.

[0051] The hind limb fixation part 130 is used to fix the hind limbs of the imaging animal.

[0052] like Figure 1 As shown, the hind limb fixation part 130 can be designed as a groove structure, which provides ample operating space, making it convenient for the operator to fix the hind limb of the imaging animal to or remove it from the hind limb fixation part 130.

[0053] In some embodiments, the hind limb fixation portion can also be designed as other structures (such as...). Figure 4A For example, the hind limb fixation part can be designed as a perforated structure with a cavity extending through it. After the hind limb of the imaging animal is inserted into the cavity of the hind limb fixation part, the hind limb can be effectively fixed under the constraint of the cavity. The perforated structure not only makes it easier to fix the animal's hind limb but also avoids compressing it, making subsequent imaging areas easier to distinguish and resulting in better imaging effects.

[0054] Animals used in animal experiments are typically four-limbed animals. Accordingly, the tray 100 is provided with two forelimb fixing parts 120 and two hindlimb fixing parts 130 to fix the four limbs (i.e., two forelimbs and two hindlimbs) of the imaging animal.

[0055] The tail fixing part 140 is used to fix the tail of the imaging animal. It should be noted that for some imaging animals without tails (e.g., guinea pigs) or with relatively short tails (where tail movement has negligible effects on imaging, e.g., weasels), the tail fixing part 140 can be omitted. For some imaging animals with longer tails (e.g., mice), the tail fixing part 140 is necessary.

[0056] like Figure 1 As shown, the tail fixing part 140 can be designed as a groove structure, which provides ample operating space, making it convenient for the operator to fix the tail of the imaging animal to the tail fixing part 140 or remove it from the tail fixing part 140.

[0057] The tail fixing part 140 can also be designed as other structures (not shown). For example, the tail fixing part 140 can also be designed as a perforated structure (i.e., a structure with a cavity). After the tail of the imaging animal is inserted into the cavity of the tail fixing part 140, the tail of the imaging animal can be effectively fixed under the constraint of the cavity.

[0058] It is worth noting that in some scenarios, it is necessary to insert an indwelling needle into the tail of the imaging animal. Due to the fixing effect of the tail fixing part 140, the indwelling needle located in the tail of the imaging animal is also fixed. This prevents the indwelling needle from failing due to changes in position.

[0059] The advantages of using a tray-type single-imaging animal fixation device 10 include, but are not limited to: (1) enabling rapid switching of samples (imaging animals, such as mice) on different scanning devices (e.g., CT devices, MR devices, PET devices, etc.) without changing the relative position between the sample and the tray, thereby achieving the fusion of multimodal images; (2) enabling the establishment of multimodal image templates, thereby establishing a multimodal image database.

[0060] In some embodiments, the shape of the tray 100 is consistent with the shape of the imaging animal. Specifically, the size of the surface of the tray 100 that contacts the imaging animal can be designed according to the body size of the imaging animal. Taking a mouse as an example, based on mouse ergonomic design, when the mouse is placed in the tray 100, the mouse's body can fit better with the tray 100, which helps to achieve rapid fixation of various parts of the mouse, tail vein injection, positioning, and subsequent imaging.

[0061] In some embodiments, such as Figure 1 As shown, the tray 100 is further provided with a first marker receiving portion 150 adjacent to the forelimb fixation portion 120 and a second marker receiving portion 160 adjacent to the hindlimb fixation portion 130. Both the first marker receiving portion 150 and the second marker receiving portion 160 are used to hold markers (sometimes also called tracers), which are visible in the medical images of the imaging animal. The markers can be solid or liquid. The medical images include one or more of magnetic resonance images, positron emission tomography (PET) images, computed tomography (CT) images, and single-photon emission tomography (SPECT) images. In some embodiments, the markers can be visible in multiple imaging modalities. For example, the markers can be visible in both CT and MR images simultaneously. The ability of the markers to be visible in multiple imaging modalities facilitates image localization and registration. In some embodiments, the markers can be placed in a specific location in a feasible manner. Since the markers are visible in medical images, by using the first marker receiving portion 150 and the second marker receiving portion 160, and by setting multiple markers, the fusion accuracy of multimodal images can be improved, enabling rapid positioning and registration. This solves the pain points in existing technologies where image fusion accuracy is limited by the motion accuracy of mechanical structures and the positioning of the imaging animal. Furthermore, since the first marker receiving portion 150 and the second marker receiving portion 160 are located at the four corners of the tray, not only is the space distribution of the tray fully utilized, but interference between the first marker receiving portion 150 and the second marker receiving portion 160 and the body of the imaging animal is also avoided, making the markers more visible in medical images and facilitating positioning. In some embodiments, the structure of the first marker receiving portion 150 and / or the second marker receiving portion 160 is similar to... Figure 6A and 6B The structure of the marker receiving portion 60 shown is the same or similar.

[0062] Figure 4A This is a schematic diagram of the structure of another tray for a multi-image animal restraint device, as shown in some embodiments of this specification. Figure 4B This is a magnified structural diagram of area I of the tray.

[0063] like Figure 4A As shown, the tray 400 includes a first end 410 and a second end 420. The tray 400 can constitute a single imaging animal fixation device 40 for accommodating a single imaging animal.

[0064] In some embodiments, the shape of the tray 400 is consistent with the shape of the imaging animal. Specifically, the dimensions of the surface of the tray 400 that contacts the imaging animal can be designed according to the body size of the imaging animal. Taking a mouse as an example, based on mouse ergonomic design, when the mouse is placed in the tray 400, the mouse's body can fit better with the tray 400, which helps to achieve rapid fixation of various parts of the mouse, tail vein injection, positioning, and subsequent imaging.

[0065] The first end portion 410 is configured to fix the head of the imaging animal. The second end portion 420 is disposed opposite to the first end portion 410. In some embodiments, the second end portion 420 may be configured to fix the tail of the imaging animal. This is merely an example. Figure 4A As shown, the second end portion 420 is provided with a tail fixing portion 140 for fixing the tail of the imaging animal. In some embodiments, the second end portion 420 further includes a slot configured to engage with the slot structure of the support portion.

[0066] In some embodiments, a head fixing part is provided on the first end 410, which includes a tooth bar 112 for fixing the teeth of the imaging animal (e.g., rodents such as mice and rabbits) in a biting motion. In some embodiments, the head fixing part of the tray 400 is similar to the head fixing part 110 of the tray 100, and may also include structures such as a head cover and ear bars.

[0067] In some embodiments, an anesthesia interface 411 is provided on the first end 410, and the anesthesia interface 411 is configured to deliver anesthetic gas to the imaging animal.

[0068] Figure 5 This is a schematic diagram of the anesthesia interface according to some embodiments of this specification. For example... Figure 5As shown, the anesthesia interface 411 includes a first anesthesia channel 411-1 and a second anesthesia channel 411-2. The first anesthesia channel 411-1 includes a first end 411-1A and a second end 411-1B, and the second anesthesia channel 411-2 includes a third end 411-2A and a fourth end 411-2B. The first end 411-1A is the inlet of the anesthetic gas, and the third end 411-2A is the outlet of the anesthetic gas and is positioned close to the nose of the imaging animal. By placing the third end at the nose of the imaging animal, the anesthetic gas can be absorbed by the imaging animal at the outlet, which helps to improve the anesthetic effect.

[0069] In some embodiments, the second end 411-1B is connected to the fourth end 411-2B, and at the connection point, there is a preset angle between the second end 411-1B and the fourth end 411-2B. For example, the preset angle can be 30°. In some embodiments, the preset angle can also be other angles, such as 25°, 35°, etc.

[0070] For example only, such as Figure 5 As shown, anesthetic gas can be injected into the anesthesia interface 411 through the first end 411-1A, pass through the first anesthesia channel 411-1 and the second anesthesia channel 411-2, and flow out from the third end 411-2A to anesthetize the imaging animal.

[0071] In some embodiments of this specification, by setting an anesthesia interface and setting a preset angle between the second and fourth ends, the anesthetic gas can be directly aimed at the nose of the imaging animal after passing through the first and second anesthesia channels, without the need for additional pipes or accessories, making the anesthesia device simpler and improving the anesthesia effect.

[0072] In some embodiments, such as Figure 4A As shown, the tray 400 has a first hole structure 430 and a second hole structure 440 that penetrate the tray 400. The first hole structure 430 includes two through holes configured for the two forelimbs of the imaging animal to pass through, and the second hole structure 440 includes two through holes configured for the two hindlimbs of the imaging animal to pass through. By inserting the forelimbs of the imaging animal into the first hole structure 430 and the hindlimbs into the second hole structure 440, the forelimbs and hindlimbs of the imaging animal can be effectively fixed within the constraints of the hole structures.

[0073] In some embodiments, the through holes of the first hole structure 430 and the second hole structure 440 can be waist-shaped holes. Setting them as waist-shaped holes not only simplifies the structure but also allows the limbs of imaging animals of a certain size range to pass through and be fixed, without the need for additional fixing accessories or to replace other sizes or different trays.

[0074] In some embodiments of this specification, the forelimbs and hindlimbs of the imaging animal are fixed by a perforated structure. The limbs can be naturally fixed after passing through the perforated structure. This not only makes it easier to fix the forelimbs and hindlimbs of the animal, but also avoids compressing the forelimbs and hindlimbs of the imaging animal, reduces contact between different parts, and facilitates separate imaging and structural analysis of the limbs or body parts of the imaging animal.

[0075] In some embodiments, continue to refer to Figure 4A The tray 400 is provided with a fixing structure 450 and a marker receiving part (such as...). Figure 1 The first marker receiving portion 150 and the second marker receiving portion 160, Figure 6A and 6B The marker receiving portion 60 is detachably mounted to the tray 400 via a fixing structure 450. The marker receiving portion can be connected to the fixing structure 450 via threaded connection, snap-fit, or other means. There can be multiple fixing structures 450. For example, such as... Figure 4A As shown, the tray 400 may have two fixing structures 450 respectively provided near the first end 410 and the second end 420.

[0076] In some embodiments, such as Figure 4B As shown, the fixing structure 450 is a retaining ring structure. The retaining ring structure includes a resilient retaining ring arm 451, which is configured to fix the marker receiving portion. The structure of the marker receiving portion matches the retaining ring structure. During installation, the marker receiving portion can be inserted into the retaining ring structure through the opening of the retaining ring arm 451, and the retaining ring arm 451 clamps the marker receiving portion, thereby fixing the marker receiving portion. This is only an example. Figure 8A As shown, the second receiving channel 630 of the marker receiving part 60 cooperates with the retaining ring structure to fix the marker receiving part 60 to the fixing structure 450. The retaining ring structure allows for easy disassembly and installation of the marker receiving part. The marker receiving part can be temporarily configured according to experimental needs, and can be set for single use or reuse, while the main structure of the tray itself can be used continuously.

[0077] Figure 6A and 6B This is a schematic diagram of the structure of the marker receiving portion according to some embodiments of this specification.

[0078] like Figure 6A and 6BAs shown, the marker receiving portion 60 includes a first receiving channel 610, a second receiving channel 630, and a marker receiving cavity 620. The first receiving channel 610 is configured to inject the marker; the second receiving channel 630 is configured to expel gas when the marker is injected; the marker receiving cavity 620 communicates with both the first and second receiving channels 610 and 630, and is configured to receive the marker. In some embodiments, the marker is a liquid, and the marker can be of various types, such as water, positron-emitting radionuclide-labeled glucose solution, etc. The marker is visible in at least one imaging modality.

[0079] In some embodiments, the marker is visible in at least one first modality of medical imaging. For example, the first modality includes at least one of positron emission tomography (PET), single-photon emission imaging (SPEE), or magnetic resonance imaging (MRI).

[0080] In some embodiments, the marker receiving portion 60 is visible in at least one second modality of medical imaging. The second modality includes X-ray imaging. For example, the marker receiving portion 60 can be made of plastic.

[0081] In some embodiments of this specification, since the marker is visible in the first modality of the medical image and the marker receiving portion is visible in the second modality of the medical image, the fusion accuracy of the multimodal images can be improved by using the marker and the marker receiving portion. Furthermore, since the marker receiving portion is located at the four corners of the tray, it not only makes full use of the tray's spatial distribution but also avoids interference between the marker receiving portion and the imaging animal's body, making the marker more visible in the medical image and easier to locate.

[0082] In some embodiments, the first receiving channel 610 and the second receiving channel 630 are cylindrical and hollow inside. In some embodiments, the first receiving channel 610 and the second receiving channel 630 may also include other shapes, such as hollow cuboids, triangular prisms, etc. In some embodiments, the shapes of the first receiving channel 610 and the second receiving channel 630 may be the same or different. In some embodiments, the marker receiving cavity 620 may be spherical and hollow inside. For example, a sphere with a diameter of 4 mm. In some embodiments, the marker receiving cavity 620 may also include other shapes, such as hollow cuboids, cubes, etc.

[0083] In some embodiments, the center of the marker receiving cavity 620 is located on the central axis of the first receiving channel 610. For example... Figure 6BAs shown, the central axis of the first accommodating channel 610 is axis 640, and the center of the marker accommodating cavity 620 is also located on axis 640. By setting the center of the marker accommodating cavity 620 to be located on the central axis of the first accommodating channel 610, registration during multimodal imaging can be facilitated, and registration efficiency and accuracy can be improved.

[0084] In some embodiments, the marker receiving portion 60 is formed by 3D printing. In some embodiments, the marker receiving portion 60 may also be formed by other methods, such as injection molding.

[0085] In some embodiments of this specification, the first accommodating channel, the second accommodating channel, and the marker accommodating cavity are coaxially arranged such that the markers developed in the first modality of the medical image and the marker accommodating portions developed in the second modality of the medical image have the same central axis, thereby enabling precise fusion of multimodal images by means of the markers and the marker accommodating portions.

[0086] In some embodiments, the length of the first accommodating channel 610 is greater than that of the second accommodating channel 630, and the diameter of the first accommodating channel 610 is greater than that of the second accommodating channel 630. For example, the length of the first accommodating channel 610 may be 7.5 mm and the diameter may be 1.6 mm; the diameter of the second accommodating channel 630 may be 0.6 mm.

[0087] In some embodiments of this specification, the length of the first accommodating channel is set to be greater than that of the second accommodating channel. Extending the length of the first accommodating channel helps researchers more precisely control the injection of the marker and prevents the marker from overflowing during injection. Furthermore, setting the diameter of the second accommodating channel to be smaller than that of the first accommodating channel reduces the diameter of the second accommodating channel. This allows the marker solution surface at the outlet of the second accommodating channel to prevent it from flowing out due to surface tension after the gas is successfully expelled during the injection process.

[0088] This specification also provides a multi-imaging animal restraint device, which includes multiple (two or more) single-imaging animal restraint devices (such as single-imaging animal restraint devices 10 or 40) connected together. The single-imaging animal restraint devices may be constructed from trays. The multiple single-imaging animal restraint devices may be arranged in one layer or in multiple layers (at least two layers). Using this multi-imaging animal restraint device, simultaneous scanning of multiple imaging animals (e.g., multiple mice) can be achieved.

[0089] When the plurality of single-image animal restraints are arranged in at least two layers, the single-image animal restraints in different layers can be connected together by a support. The support includes a first part and a second part disposed opposite to each other. The first part is used to support a first end of the single-image animal restraint (such as a head restraint in the first end), and the second part is used to support a second end of the single-image animal restraint (such as a tail restraint in the second end).

[0090] In some embodiments, the first portion is connected to the single-image animal restraint device via a snap-fit ​​structure (e.g., a slot or a snap fastener). In some embodiments, the second portion is connected to the single-image animal restraint device via a snap-fit ​​structure (e.g., a slot or a snap fastener).

[0091] Figure 2 This is a schematic diagram of a dual-layer multi-imaging animal restraint device according to some embodiments of this specification. Figure 2 As shown, the multi-image animal restraint device 20 includes four single-image animal restraint devices 10 connected together by a support portion. The four single-image animal restraint devices 10 are arranged in two layers, with two single-image animal restraint devices 10 in each layer. The support portion includes a first part 210 and a second part 220. The first part 210 is used to support the four head restraint devices 110. The second part 220 is used to fix the four tail restraint devices 140.

[0092] In some embodiments, the bottom of the head fixing portion 110 has a first groove, and the edge of the first portion 210 is embedded in the first groove to support the single-image animal fixing device 10. In some embodiments, the bottom of the tail fixing portion 140 has a second groove, and the edge of the second portion 220 is embedded in the second groove to support the single-image animal fixing device 10. In some embodiments, the edge of the first portion 210 has a first groove, and the head fixing portion 110 is embedded in the first groove to obtain support for the first portion 210. Similarly, the edge of the second portion 220 has a second groove, and the tail fixing portion 140 is embedded in the second groove to obtain support for the second portion 220.

[0093] Different support structures allow for various combination methods to meet different usage requirements. For example, see reference. Figure 2 Both the first part 210 and the second part 220 retain only the lower half (e.g., omitting the upper T-shaped structure) to achieve a combination of two single-layer single-imaging animal fixation devices 10. For example, see reference... Figure 2 When the second layer is changed to have only one single imaging animal fixation device, it allows the upper end of the first part 210 and the upper end of the second part 220 to be designed to be shorter (e.g., simplified from a T-shaped structure to a handle-shaped structure).

[0094] In some embodiments, reference Figure 2 The support also includes a third portion 230 between the first portion 210 and the second portion 220. Based on the third portion 230, the plurality of single-image animal restraint devices 10 can be more stably combined, and this facilitates the overall movement of the multi-image animal restraint device 20.

[0095] It should be understood that the multi-imaging animal restraint 20 can also be used to support other single-imaging animal restraints or trays disclosed in this specification, such as... Figure 4A The single-image animal fixation device 40 shown.

[0096] Figure 7A This is a schematic diagram of the support portion of a multi-image animal fixation device according to some embodiments of this specification. Figure 7B This is an enlarged structural diagram of region II of the support section.

[0097] like Figure 7A As shown, the multi-imaging animal restraint 70 includes a support 700 configured to support a plurality of trays 400. The trays 400 can constitute a single-imaging animal restraint 40 for accommodating an imaging animal. In some embodiments, the number of trays 400 connected to the support 700 can be 2-4. This is merely an example. Figure 8A As shown, four trays 400 are connected together by a support 700. In some embodiments, the support 700 and the trays 400 are detachably connected. For example, by snap-fit ​​connection, slot connection, etc.

[0098] The support portion 700 includes a first portion 710 and a second portion 720 disposed opposite to each other. The first portion 710 is configured to support a first end of the tray 400; the second portion 720 is configured to support a second end of the tray 400. (This is merely an example.) Figure 8A As shown, the first end of the tray 400 mates with the first part 710, and the second end mates with the second part 720 to achieve the connection between the tray 400 and the support part 700.

[0099] In some embodiments, the first portion 710 is provided with a label 711 for placing the head of the imaging animal, allowing the user to quickly locate the first end of the mounting tray. The label 711 can be represented in various ways, such as by color, by characters, or by patterns. This is merely an example. Figure 7A As shown, identifier 711 is the character "H".

[0100] In some embodiments, such as Figure 7AAs shown, the first portion 710 is provided with a snap-fit ​​structure 712, which is configured to snap into the first end 410 of the tray 400. In some embodiments, the second portion 720 is provided with a slot structure 721, which is configured to snap into the second end 420 of the tray 400. For example, the slot structure 721 of the second portion 720 snaps into a slot 460. The slot structure 721 and the slot 460 can have various shapes, as long as their shapes match to achieve snap-fit.

[0101] In some embodiments, see Figure 7B and Figure 4B The snap-fit ​​structure 712 includes an outwardly protruding snap-fit ​​boss 712-1 and an inwardly recessed snap-fit ​​structure 411-3 on the anesthesia interface 411. The snap-fit ​​boss 712-1 is configured to be embedded in the snap-fit ​​structure 411-3 to achieve snap-fit ​​between the anesthesia interface 411 and the snap-fit ​​structure 712. The snap-fit ​​structure 712 has a certain degree of elasticity, and the anesthesia interface 411 can be inserted into the snap-fit ​​structure 712 through the opening. Installation is completed when the snap-fit ​​boss 712-1 is embedded in the snap-fit ​​structure 411-3.

[0102] like Figure 8B As shown, when the snap-fit ​​boss 712-1 is inserted into the snap-fit ​​structure 411-3, the snap-fit ​​boss 712-1 abuts against the anesthesia interface 411, and its protruding portion can restrict the movement of the anesthesia interface 411, thereby achieving the purpose of fixing the anesthesia interface 411 and thus realizing the stable installation of the tray. The snap-fit ​​boss 712-1 and the snap-fit ​​structure 411-3 can have various shapes, as long as their shapes match and can achieve snap-fit.

[0103] In some embodiments of this specification, by providing a snap-fit ​​protrusion on the snap-fit ​​structure and a snap-fit ​​structure on the anesthesia interface, the cooperation of the snap-fit ​​protrusion and the snap-fit ​​structure can enable the tray to be quickly and easily installed onto the support, and improve the installation stability of the tray.

[0104] In some embodiments, the support portion 700 further includes a third portion 730 located between the first portion 710 and the second portion 720, the third portion 730 having a cutout portion. The cutout portion can include various shapes, such as square, circular, etc. This is merely an example. Figure 7A As shown, the third part 730 has multiple perforated sections. By providing perforated sections on the third part of the support, it is beneficial to reduce the weight of the support, thereby reducing the weight of the multi-image animal fixation device.

[0105] In some embodiments, such as Figure 9As shown, the bottom of the lowest tray 400 and the third part 730 of the support have a certain distance to ensure that the limbs of the imaging animal are not squeezed and can be extended naturally.

[0106] This specification also provides an animal cabin, which includes a cabin body for accommodating one or more multi-image animal restraint devices.

[0107] In some embodiments, the multi-imaging animal restraint device is detachably connected to the cabin. By way of example only, the multi-imaging animal restraint device can be detachably secured to the inner wall of the cabin via a snap-fit ​​connection.

[0108] Traditional animal chambers have slots on their inner walls for securing imaging animals. On one hand, these slots cannot be removed from the animal chamber to secure the imaging animal, making it impossible to prepare the animal for the scan during use (e.g., to secure it). Furthermore, the large size of the animal chamber occupies considerable space in scanning scenarios. On the other hand, the fixed slot design of a single animal chamber hinders flexible support for multiple simultaneous scanning methods (especially multi-layer simultaneous scanning). The single-imaging animal fixation device and multi-imaging animal fixation device provided in the embodiments of this specification separate the centralized storage function and auxiliary imaging function of the traditional animal chamber, saving more space in scanning scenarios and supporting more simultaneous scanning methods (especially multi-layer simultaneous scanning). In addition, relying on the flexible and versatile multi-imaging animal fixation device (especially a multi-layer structure multi-imaging animal fixation device), the animal chamber provided in the embodiments of this specification can centrally store more secured imaging animals. Furthermore, the single / multi-imaging animal restraint device in this manual has built-in restraint and positioning functions, and its simple structure and easy manufacturing make it easy to place inside existing animal cabins. It is not only suitable for various types of animal cabins and scanning equipment, but also allows for the configuration of multiple and / or different models of multi-imaging animal restraint devices for a single animal imaging system to meet different user needs.

[0109] In some embodiments, an animal cabin includes one or more multi-imaging animal restraints. Each multi-imaging animal restraint can be configured with multiple trays. Of course, the multiple multi-imaging animal restraints can be all identical, partially identical, or all different models. The multiple trays can be all identical, partially identical, or all different models. When multiple multi-imaging animal restraints are placed in an animal cabin, the multiple multi-imaging animal restraints can be arranged along the axial direction (i.e., longitudinal direction) of the animal cabin. This can further increase the number of imaging animals that can be scanned simultaneously. For example, if a multi-imaging animal restraint has four tray positions, and two multi-imaging animal restraints can be placed in each animal cabin simultaneously, then eight imaging animals can be scanned at once.

[0110] Figure 3 This is a structural schematic diagram of the animal compartment according to some embodiments of this specification. For example... Figure 3 As shown, the animal cabin 30 includes a cabin body 300 and a multi-image animal restraint device 20. Figure 10 This is a structural schematic diagram of yet another animal cabin shown according to some embodiments of this specification. For example... Figure 10 As shown, the animal cabin 1000 includes a cabin body 1010 and a multi-image animal restraint device 70. Both the multi-image animal restraint device 70 and the multi-image animal restraint device 20 shown in the figure have four tray positions, which can accommodate four trays at the same time.

[0111] In some embodiments, for larger imaging animals (e.g., guinea pigs), a multi-imaging animal restraint device with two tray positions arranged vertically can be provided. The animal compartment can accommodate only the two trays arranged vertically in two layers.

[0112] In some embodiments, the third portion of the support has an arc-shaped bottom surface that matches the inner wall of the cabin. In some embodiments, the radius of the arc of the arc-shaped bottom surface of the support is the same as the radius of the arc of the inner wall of the cabin. The multi-image animal restraint device composed of the support and the tray can be directly placed inside the cabin without the need for additional fixing structures to secure the multi-image animal restraint device. This configuration further improves assembly efficiency and enhances applicability.

[0113] In some embodiments, this specification also provides a tray for an imaging animal restraint device, which can be a tray for the aforementioned multi-imaging animal restraint device. Of course, the tray can also be used alone as a single-imaging animal restraint device. In some embodiments, a single-imaging animal restraint device may also be provided, including a support having a tray position, the support being detachably connected to a tray.

[0114] This specification also provides an animal imaging system, which includes a scanning imaging device having a scanning cavity. The scanning imaging device includes one of the following: computed tomography (CT) equipment, magnetic resonance (MR) equipment, positron emission tomography (PET) equipment, and single-photon emission tomography (SPECT) equipment, or a combination of multiple modal imaging devices (e.g., PET-CT equipment, PET-MR equipment, etc.). In some embodiments, the animal imaging system further includes a multi-imaging animal restraint device or an animal chamber. The multi-imaging animal restraint device or animal chamber can enter the scanning cavity so that the scanning imaging device can scan and image the animal.

[0115] The beneficial effects that the embodiments of this specification may bring include, but are not limited to: (1) providing a single-imaging animal fixation device or tray, which can realize the rapid switching of samples (imaging animals, such as mice) on different scanning devices (e.g., CT devices, MR devices, PET devices, etc.) without changing the relative position between the sample and the tray, thereby realizing the fusion of multimodal images; (2) relying on the tray, multimodal image templates can be established, thereby establishing a multimodal image database; (3) providing a multi-imaging animal fixation device, which can realize the synchronous scanning of multiple imaging animals (e.g., multiple mice); (4) the tray and the multi-imaging animal fixation device separate the centralized storage function and auxiliary imaging function of the traditional animal cabin, which saves more space in the scanning scenario and supports more synchronous scanning methods (especially multi-layer synchronous scanning methods); (5) by detachably connecting the marker receiving part to the tray, it is convenient to inject the marker and (6) By setting an anesthesia interface and setting a preset angle between the second and fourth ends, the anesthetic gas can be directly aimed at the nose of the imaging animal after passing through the first and second anesthesia channels, so that the anesthetic gas can be absorbed by the imaging animal at the outlet position without the need for additional pipes or accessories, making the anesthesia device simpler and improving the anesthesia effect; (7) The forelimbs and hindlimbs of the imaging animal are fixed through the hole structure, which not only makes it easier to fix the forelimbs and hindlimbs of the animal, but also does not put pressure on the forelimbs and hindlimbs of the imaging animal, and reduces the contact between different parts, while also facilitating separate imaging and structural analysis of the limbs or body parts of the imaging animal; (8) Since the marker can be visualized in the first modality of medical images and the marker receiving part can be visualized in the second modality of medical images, the fusion accuracy of multimodal images can be improved by using the marker and the marker receiving part. In addition, since the marker receiving part is set at the four corners of the tray, it not only makes full use of the space distribution of the tray, but also avoids interference between the marker receiving part and the body of the imaging animal, making the marker more obvious in the medical images and easier to locate. (9) By setting a snap-fit ​​protrusion on the snap-fit ​​structure and a snap-fit ​​structure on the anesthesia interface, the single-image animal fixation device can be quickly and easily installed onto the support by utilizing the cooperation of the snap-fit ​​protrusion and the snap-fit ​​structure, thereby improving the installation stability of the single-image animal fixation device; (10) An animal cabin is provided, which can freely combine and place multiple imaging animal fixation devices and / or trays to achieve simultaneous scanning of different animal types or numbers, meeting different experimental needs. It should be noted that different embodiments may produce different beneficial effects. In different embodiments, the beneficial effects that may be produced can be any one or a combination of the above, or any other possible beneficial effects.

[0116] The basic concepts have been described above. Obviously, for those skilled in the art, the detailed disclosure above is merely illustrative and does not constitute a limitation of this specification. Although not explicitly stated herein, those skilled in the art may make various modifications, improvements, and corrections to this specification. Such modifications, improvements, and corrections are suggested in this specification and therefore remain within the spirit and scope of the exemplary embodiments described herein.

[0117] Furthermore, this specification uses specific terms to describe embodiments thereof. For example, "an embodiment," "one embodiment," and / or "some embodiments" refer to a particular feature, structure, or characteristic associated with at least one embodiment of this specification. Therefore, it should be emphasized and noted that references to "an embodiment," "one embodiment," or "an alternative embodiment" in different locations throughout this specification do not necessarily refer to the same embodiment. Moreover, certain features, structures, or characteristics in one or more embodiments of this specification can be appropriately combined.

Claims

1. A multi-image animal restraint device, characterized in that, include: A support portion and a plurality of trays, the support portion being configured to support the plurality of trays; The tray is detachably connected to the support. The tray includes a first end configured to hold the head of the imaging animal. Each of the trays has a detachably connected marker receiving portion configured to receive a marker that is developable in at least one imaging modality.

2. The multi-imaging animal fixation device according to claim 1, characterized in that, The tray includes a second end, which is disposed opposite to the first end. The support portion includes a first part and a second part that are disposed opposite to each other; The first portion is configured to support a first end of the tray; The second portion is configured to support the second end of the tray; The support portion also includes a third portion between the first portion and the second portion, and the third portion has a hollowed-out portion.

3. The multi-imaging animal fixation device according to claim 1, characterized in that, An anesthesia interface is provided on the first end, and the anesthesia interface is configured to deliver anesthetic gas to the imaging animal; The first end is also provided with a tooth rod for fixing the teeth of the imaging animal in a bite position.

4. The multi-imaging animal fixation device according to claim 1, characterized in that, The number of trays that the support is configured to support is 2-4.

5. The multi-imaging animal fixation device according to claim 1, characterized in that, The tray has a first hole structure and a second hole structure that penetrate the tray. The first hole structure includes two through holes configured for the two forelimbs of the imaging animal to pass through, and the second hole structure includes two through holes configured for the two hindlimbs of the imaging animal to pass through.

6. The multi-image animal fixation device according to claim 5, wherein the through hole is a waist-shaped hole.

7. The multi-imaging animal fixation device according to claim 1, characterized in that, The tray is provided with a fixing structure, and the fixing structure has multiple parts, through which the multiple marker receiving parts are detachably installed on the tray.

8. The multi-imaging animal fixation device according to claim 7, characterized in that, The fixing structure is a retaining ring structure, which includes a resilient retaining ring arm configured to fix the marker receiving portion.

9. The multi-imaging animal fixation device according to claim 1, characterized in that, The marker receiving portion includes a first receiving channel, a second receiving channel, and a marker receiving cavity. The first receiving channel is configured to inject the marker. The second receiving channel is configured to expel gas during injection of the marker. The marker receiving cavity is connected to the first receiving channel and the second receiving channel respectively, and is configured to receive the marker.

10. The multi-imaging animal fixation device according to claim 9, characterized in that, The first accommodating channel is cylindrical, and the marker accommodating cavity is spherical, with the center of the marker accommodating cavity located on the central axis of the first accommodating channel.

11. The multi-imaging animal fixation device according to claim 1, characterized in that, The marker is a liquid, the marker is developable in at least one first mode of imaging, and the marker receiving portion is developable in at least one second mode of imaging. The first mode includes at least one of positron emission tomography, single-photon emission imaging, or magnetic resonance imaging, and the second mode includes X-ray imaging.

12. The multi-imaging animal fixation device according to claim 9, characterized in that, The marker receiving portion is 3D printed; the diameter of the first receiving channel is larger than that of the second receiving channel.

13. The multi-imaging animal fixation device according to claim 2, characterized in that, The first part is provided with a mark for placing the head of the imaging animal.

14. The multi-imaging animal fixation device according to claim 3, characterized in that, The support includes a first portion configured to support a first end of the tray, the first portion being provided with a snap-fit ​​structure configured to snap into the first end of the tray; The snap-fit ​​structure includes an outwardly protruding snap-fit ​​boss, and the anesthesia interface is provided with an inwardly recessed snap-fit ​​structure. The buckle protrusion is configured to be embedded in the buckle structure to achieve the snap-fit ​​connection between the anesthesia interface and the snap-fit ​​structure.

15. The multi-imaging animal fixation device according to claim 3, characterized in that, The anesthesia interface includes a first anesthesia channel and a second anesthesia channel. The first anesthesia channel includes a first end and a second end, and the second anesthesia channel includes a third end and a fourth end. The first end is the inlet of the anesthetic gas, and the third end is the outlet of the anesthetic gas and is positioned close to the nose of the imaging animal. The second end is connected to the fourth end, and at the connection point, there is a preset angle between the second end and the fourth end.

16. A tray for fixing imaging animals, characterized in that, The tray is configured to accommodate a single imaging animal. The tray includes a first end and a second end, the first end being configured to fix the head of the imaging animal, and the second end being disposed opposite to the first end; The tray is detachably connected to the support of the multi-imaging animal restraint device, which is detachably placed inside the animal compartment. The tray has a detachably connected marker receiving portion configured to receive markers that are developable in at least one imaging modality.

17. An animal cabin, characterized in that, include: hull; as well as The multi-imaging animal restraint device as described in any one of claims 1 to 15, wherein the multi-imaging animal restraint device is detachably placed within the cabin.

18. An animal imaging system, comprising: A scanning imaging device, the scanning imaging device having a scanning cavity; as well as The multi-imaging animal fixation device as described in any one of claims 1 to 15 is capable of entering the scanning cavity; Or, as in claim 17, the animal compartment is capable of entering the scanning cavity.

19. The animal imaging system according to claim 18, characterized in that, The scanning imaging device is one of the following: a computed tomography (CT) device, a magnetic resonance imaging (MRI) device, a positron emission tomography (PET) device, or a single-photon emission tomography (SPECT) device, or a multimodal imaging device combining multiple of these devices.

Images