Delivery assembly and left atrial appendage occluder system

Abstract

The invention discloses a conveying assembly and a left atrial appendage occluder system. The conveying assembly comprises a conveying catheter and a pushing mechanism suitable for passing through the conveying catheter. The pushing mechanism comprises a pushing catheter and a pre-release part penetrating through the pushing catheter, the far end of the pushing catheter and the far end of the pre-release part are provided with a first connecting structure and a second connecting structure respectively, the near end of the second connecting structure is detachably connected with the first connecting structure, and the far end of the second connecting structure is detachably connected with the left auricle plugging device. An operator can stably push the left auricle plugging device to a target position through the pushing mechanism; after a target position is reached, the second connecting structure is separated from the first connecting structure, the pushing mechanism pre-releases the left auricle plugging device, and an operator can visually observe the implantation state of the left auricle plugging device; if the implantation state does not reach the standard, the pre-release part is controlled to recycle the left auricle plugging device for pre-release again until the implantation state reaches the standard; after the standard is reached, the second connecting structure is separated from the left auricle plugging device, and the left auricle plugging device is released, so that the effectiveness and the safety of the operation are improved.

Description

Technical Field

[0001] This application relates to the field of medical device technology, and more particularly to a delivery assembly and a left atrial appendage occluder delivery system. Background Technology

[0002] Atrial fibrillation (AF) is one of the most common arrhythmias in clinical practice. It can lead to thrombus formation in the left atrial appendage, and thrombus detachment can cause thromboembolic diseases. The Framingham Study (a long-term epidemiological study aimed at identifying risk factors for cardiovascular disease) showed that AF is significantly associated with stroke events. Transcatheter left atrial appendage occlusion can prevent thrombi formed in the left atrial appendage from entering the systemic circulation, thereby effectively reducing the risk of stroke and thromboembolism.

[0003] In practical application, the operator manipulates the left atrial appendage occluder to detach from the delivery catheter in the landing area within the left atrial appendage, restoring it to its preset shape. At this point, the operator needs to accurately check the occluder's status using medical imaging. If the status does not meet the implantation criteria, the operator retrieves the occluder, adjusts it, and repositions it. This entire process should be precisely observable and repeatable to ensure the effectiveness and safety of transcatheter left atrial appendage occlusion. Therefore, continuous improvement of the left atrial appendage occlusion system remains of significant clinical importance. Summary of the Invention

[0004] The purpose of this application is to provide a delivery component and a left atrial appendage occluder delivery system that can pre-release and retrieve the left atrial appendage occluder, allowing the operator to more intuitively and accurately observe the implantation status of the left atrial appendage occluder and adjust the implantation status of the left atrial appendage occluder in a timely manner until the implantation standard is met.

[0005] The technical solution provided in this application is as follows:

[0006] A delivery assembly for delivering a left atrial appendage occluder, comprising:

[0007] A delivery conduit having a first internal lumen extending axially;

[0008] The pusher mechanism is adapted to pass through the first inner cavity, and the distal end of the pusher mechanism is detachably connected to the left atrial appendage occluder;

[0009] The pushing mechanism includes a pushing catheter and a pre-release component. The pushing catheter has a second inner cavity that extends axially, and the pre-release component passes through the second inner cavity. The distal end of the pushing catheter is provided with a first connecting structure, and the distal end of the pre-release component is provided with a second connecting structure. The proximal end of the second connecting structure is detachably connected to the first connecting structure, and the distal end of the second connecting structure is detachably connected to the left atrial appendage occluder.

[0010] When the second connecting structure is connected to the first connecting structure, the first connecting structure restricts the second connecting structure from rotating radially and moving axially relative to the push catheter, so as to push the left atrial appendage occluder to the target position; when the second connecting structure is separated from the first connecting structure, the push mechanism pre-releases the left atrial appendage occluder; when the second connecting structure is separated from the left atrial appendage occluder, the push mechanism releases the left atrial appendage occluder.

[0011] In some embodiments, one of the first connecting structure and the second connecting structure is provided with a slot, and the other of the first connecting structure and the second connecting structure is provided with a boss, which is adapted to engage in the slot to limit the relative rotation and axial movement between the first connecting structure and the second connecting structure.

[0012] In some embodiments, the distal end of the first connecting structure is provided with a boss, and the proximal end of the second connecting structure is provided with a slot. The distal end face of the boss is adapted to abut against the bottom of the slot so as to push the pre-release member through the push conduit. The two side walls of the boss in the circumferential direction are adapted to abut against the two side walls of the slot in the circumferential direction to limit the relative rotation between the first connecting structure and the second connecting structure.

[0013] The number of bosses is three, and the three bosses are evenly spaced along the circumference of the first connecting structure.

[0014] In some embodiments, at least the distal portion of the delivery catheter is formed by spring coil winding; and / or,

[0015] The pre-release element is made of spring coil winding at least at its distal end, or the pre-release element is made of hyaluronic acid tube.

[0016] In some embodiments, the pre-release component is a sodium hypochlorite tube, the tube wall of which has a plurality of perforated hole groups, the perforated hole groups including a plurality of perforated holes distributed circumferentially along the sodium hypochlorite tube.

[0017] There is a circumferential offset between two adjacent sets of perforated holes along the waveguide, and there is an axial overlap between the perforated holes of two adjacent sets of perforated holes along the waveguide.

[0018] In some embodiments, the perforated hole group includes three perforated holes, and the three perforated holes are evenly spaced along the circumference of the waveguide; and / or,

[0019] The offset angle between two adjacent sets of perforated holes is 15°, and the perforated holes on the sodium hypochlorite tube are offset in either a clockwise or counterclockwise direction.

[0020] This application also provides a left atrial appendage occlusion system, comprising:

[0021] Left atrial appendage occluder and the delivery assembly provided in any of the above embodiments;

[0022] The left atrial appendage occluder has a third connection structure at its proximal end, which is suitable for docking with the second connection structure.

[0023] In some embodiments, the distal end of the second connecting structure is provided with a first threaded portion, and the proximal end of the third connecting structure is provided with a second threaded portion that is adapted to the first threaded portion; the first threaded portion is one of internal thread and external thread, and the second threaded portion is the other of internal thread and external thread.

[0024] In some embodiments, the left atrial appendage occluder includes an occlusion portion, which includes a first fixing member, a first mesh body, and a second fixing member. The distal end of the first mesh body is constricted within the first fixing member, and the proximal end of the first mesh body is constricted within the second fixing member.

[0025] In some embodiments, the left atrial appendage occlusion device further includes a covering portion, the covering portion including a third fixing member, a second mesh body, and a fourth fixing member, wherein the distal end of the second mesh body is constricted within the third fixing member, and the proximal end of the second mesh body is constricted within the fourth fixing member, wherein the third fixing member and the second fixing member are connected, and a third connecting structure is disposed at the proximal end of the fourth fixing member; and,

[0026] The orthographic projection of the covering part onto the sealing part covers the sealing part.

[0027] The technical advantages of this application are as follows:

[0028] This application utilizes a push tube encased in a pre-release element, and connects the push tube and the pre-release element via a first and second connecting structure. This facilitates stable delivery of the left atrial appendage occluder during the procedure. Furthermore, due to the detachable design of the first and second connecting structures, once the left atrial appendage occluder reaches the target position (implantation site), the first and second connecting structures separate, allowing the pre-release element to continue advancing and implanting the left atrial appendage occluder into the target location, achieving pre-release. At this point, the surgeon can directly and accurately observe the implantation status of the left atrial appendage occluder through medical imaging. If the implantation status does not meet the implantation criteria, the surgeon can manipulate the pre-release element to adjust or retract it before re-releasing the left atrial appendage occluder until the implantation status is satisfactory. The second connecting structure then separates from the left atrial appendage occluder, completely releasing it, thus ensuring the effectiveness and safety of transcatheter left atrial appendage occlusion. Attached Figure Description

[0029] The present application will be further described in detail below with reference to the accompanying drawings and specific embodiments:

[0030] Figure 1 This is a schematic diagram of the left atrial appendage occluder delivery system provided in one embodiment of the present application in one state;

[0031] Figure 2This is a schematic diagram of the left atrial appendage occluder delivery system provided in one embodiment of the present application in another state;

[0032] Figure 3 This is a schematic diagram of the structure of the conveying component provided in one embodiment of the present application in one state;

[0033] Figure 4 This is a schematic diagram of the structure of the conveying component provided in one embodiment of the present application in another state.

[0034] Explanation of icon numbers:

[0035] 100. Delivery conduit;

[0036] 200. Pushing mechanism; 210. Pushing guide tube; 211. First connecting structure; 2111. Boss;

[0037] 220. Pre-release component; 221. Second connection structure; 2211. Slot; 2212. First threaded portion;

[0038] 222, Hollow hole group; 2221, Hollow hole;

[0039] 300. Left atrial appendage occluder; 310. Occlusion part; 311. First fixing element; 312. First mesh body; 320. Covering part; 321. Second mesh body. Detailed Implementation

[0040] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the specific implementation methods of this application will be described below with reference to the accompanying drawings. The accompanying drawings described below are merely some embodiments of this application. For those skilled in the art, other drawings and other implementation methods can be obtained based on these drawings without creative effort. Adjustments and improvements made without departing from the concept of this application are all within the protection scope of this application.

[0041] To keep the drawings concise, the figures in this application only schematically show the parts relevant to this application, and they do not represent the actual structure of the product. Furthermore, to make the drawings concise and easy to understand, some figures only schematically show parts of components with the same structure or function; in reality, there may be more or fewer components with the same structure or function.

[0042] In this application, unless otherwise expressly specified and limited, ordinal numbers, such as "first," "second," etc., are used only to distinguish and describe related objects, and should not be construed as indicating or implying the relative importance or order between related objects; furthermore, they do not represent the number of related objects. "And / or" is used to describe the relationship between related objects, which includes any relationship between the related objects; for example, "a and / or b" includes: "a alone," "b alone," or "a and b." The terms "installation" and "connection" should be interpreted broadly; for example, "installation" can be direct installation or installation via other components; "connection" can be direct connection or connection via other components. The term "relative arrangement" includes parallel relative or relative at a certain angle, the angle of which is not limited and is determined according to the number of objects in the relative arrangement.

[0043] In the embodiments shown in the accompanying drawings, the directional indications (such as up, down, left, right, front, and back) are relative rather than absolute when describing the structure and movement of the various components, and are not intended to limit the direction of the product during actual use.

[0044] In the embodiments of this application, "proximal end" refers to the end of the associated object closer to the operator; "distal end" refers to the end of the associated object farther from the operator. "Proximal end" and "distal end" are the position or orientation of the associated object (e.g., a component of a medical device) relative to the operator (e.g., a doctor) from the perspective of the operator using the device (e.g., a medical device). For example, "proximal end" refers to the end closer to the doctor during normal operation of the medical device, while "distal end" refers to the end farther from the doctor during normal operation of the medical device, that is, the end that first enters the patient's body.

[0045] Atrial fibrillation (AF) is one of the most common arrhythmias in clinical practice. It can lead to thrombus formation in the left atrial appendage (LAA). When this thrombus enters the systemic circulation, it can easily cause stroke and thromboembolism, posing a significant threat to public health. Approximately 5% of AAF patients experience stroke annually, and about 20% of all strokes are related to AAF. Theoretically, transcatheter left atrial appendage occlusion (TALA) involves puncturing the femoral vein and inserting an occluder into the landing area within the LAA. This occlusion can prevent the thrombus from dislodging and forming an embolism, reducing the risk of AAF embolism by at least 90%.

[0046] In practical application, the operator manipulates the left atrial appendage occluder to detach from the delivery catheter in the landing area within the left atrial appendage, restoring it to its preset shape. At this point, the operator needs to accurately check the status of the occluder using medical imaging. If the status does not meet the implantation criteria, the operator retrieves the occluder, adjusts it, and then repositions it. To ensure the effectiveness and safety of transcatheter left atrial appendage occlusion, the above process should be accurately observed and repeatable.

[0047] In response, this application provides a delivery assembly for delivering, retrieving, and releasing a left atrial appendage occluder, allowing the surgeon to more intuitively and accurately observe the implantation status of the left atrial appendage occluder and adjust the implantation status in a timely manner until the implantation standard is met.

[0048] In one example embodiment, see Figure 1 and Figure 2 The delivery assembly includes a delivery catheter 100 and a pushing mechanism 200. The delivery catheter 100 is used to establish a delivery pathway in a blood vessel and has a first inner lumen extending axially. The pushing mechanism 200 can pass through the first inner lumen, and its distal end is detachably connected to a left atrial appendage occluder 300, for pushing the left atrial appendage occluder 300 along the first inner lumen of the delivery catheter 100 to the landing area of ​​the left atrial appendage. The pushing mechanism 200 includes a pushing catheter 210 and a pre-release member 220. The pushing catheter 210 has a second inner lumen extending axially, and the pre-release member 220 passes through the second inner lumen, with its distal end extending beyond the distal end of the pushing catheter 210. The distal end of the pushing catheter 210 has a first connecting structure 211, and the distal end of the pre-release member 220 has a second connecting structure 221. The proximal end of the second connecting structure 221 is detachably connected to the first connecting structure 211, and the distal end of the second connecting structure 221 is detachably connected to the left atrial appendage occluder 300.

[0049] In practical applications, transcatheter left atrial appendage occlusion (TALA) requires the left atrial appendage occluder 300 to be inserted via the femoral vein into the landing area within the left atrial appendage. This involves a relatively long delivery path, necessitating the operator to apply a pushing force or torque to the pushing mechanism 200. To ensure force transmission, the pushing mechanism 200 requires a certain level of rigidity and support. This embodiment addresses this by using a pushing tube over the pre-release member 220 and connecting the tube to the pre-release member 220 via a first connecting structure 211 and a second connecting structure 221. This provides the pushing mechanism 200 with a certain degree of rigidity, increasing the pushing force of the pushing mechanism 200 on the left atrial appendage occluder 300. In particular, when the second connecting structure 221 is connected to the first connecting structure 211, the first connecting structure 211 restricts the radial rotation and axial movement of the second connecting structure 221 relative to the pushing catheter 210, facilitating stable delivery of the left atrial appendage occluder 300 during the procedure.

[0050] In addition, this application also sets the first connecting structure 211 and the second connecting structure 221 as detachable connecting structures. At this time, the pushing mechanism 200 is combined into a whole with sufficient rigidity. When the left atrial appendage occluder 300 is pushed to the target position (implantation position / landing area), the first connecting structure 211 and the second connecting structure 221 separate, and the distal part of the pre-release member 220 is manipulated to extend out of the distal end of the pushing catheter 210 and continue to advance so as to implant the left atrial appendage occluder 300 into the target position and realize the pre-release of the left atrial appendage occluder 300. At this point, the pre-release element 220 is not constrained by the delivery catheter 210. External forces, such as torque, that may accumulate on the delivery catheter 210 do not act on the left atrial appendage occluder 300, resulting in a more realistic shape for the occluder 300. The surgeon can then use medical imaging to observe the implantation status of the occluder 300 more directly and accurately. If the implantation status does not meet the standards, the surgeon can directly manipulate the pre-release element 220 for fine-tuning, or retract the pre-release element 220 to withdraw the occluder 300 from the target position, make necessary adjustments, and then re-pre-release the occluder 300 until the implantation status is satisfactory. This allows for precise observation of the occluder 300's implantation status during the procedure, as well as the repeated retrieval and placement of the occluder 300, which improves the implantation effect and ensures the effectiveness and safety of transcatheter left atrial appendage occlusion.

[0051] Because the pre-release component 220 and the left atrial appendage occluder 300 are detachably connected, when the surgeon observes that the left atrial appendage occluder 300 is in the correct position after implantation, the surgeon can manipulate the pre-release component 220 to separate its second connecting structure 221 from the left atrial appendage occluder 300, thereby releasing the left atrial appendage occluder 300. Then, the pushing mechanism 200 is withdrawn from the body along the inner lumen of the delivery catheter 100, thus completing the transcatheter left atrial appendage occlusion procedure.

[0052] In actual production, the first connecting structure 211 and the second connecting structure 221 can be connected by threaded engagement or snap-fit ​​engagement, but considering the operability and convenience during surgery, see [link to relevant documentation]. Figure 3 and Figure 4 In a preferred embodiment, one of the first connecting structure 211 and the second connecting structure 221 is provided with a slot 2211, and the other of the first connecting structure 211 and the second connecting structure 221 is provided with a boss 2111. The boss 2111 is adapted to be engaged in the slot 2211 to limit the relative rotation and axial movement between the first connecting structure 211 and the second connecting structure 221.

[0053] During the pushing process, the operator can advance the pushing mechanism 200 by pushing the pushing tube. At this time, due to the connection between the boss 2111 and the slot 2211, plus the rigid structure of the second connecting structure 211, it is convenient to transmit torque or pushing force to the left atrial appendage occluder 300. The first connecting structure 211 can also push the second connecting structure 221 to advance together. At the same time, there will be no relative rotation between the first connecting structure 211 and the second connecting structure 221, so the operator can stably advance the left atrial appendage occluder 300. Specifically, taking the example of a protrusion 2111 at the distal end of the first connecting structure 211 and a slot 2211 at the proximal end of the second connecting structure 221, during the pushing process, the distal end face of the protrusion 2111 can abut against the bottom of the slot 2211, so that the pushing guide 210 can push the pre-release member 220. At the same time, the two side walls of the protrusion 2111 in the circumferential direction can abut against the two side walls of the slot 2211 in the circumferential direction, thereby restricting the relative rotation between the first connecting structure 211 and the second connecting structure 221. Preferably, there are three protrusions 2111, and the three protrusions 2111 are preferably extended distally along the central axis of the pushing guide 210 and are evenly spaced along the circumference of the first connecting structure 211. This embodiment uses three protrusions 2111, which provides better pushing stability than using only one protrusion 2111; compared with using too many protrusions 2111 (e.g., five or more protrusions 2111), the production cost and material consumption are lower.

[0054] When the surgeon needs to manipulate the distal portion of the pre-release member 220 to extend beyond the distal end of the delivery catheter 210, the pre-release member 220 can be directly advanced. The boss 2111 and the slot 2211 can be directly separated, meaning the surgeon's advancement action naturally separates the first connecting structure 211 and the second connecting structure 221, allowing for continued advancement of the release member. This operation is convenient and quick, facilitating rapid surgical advancement. Conversely, when the left atrial appendage occluder 300 needs to be withdrawn, the surgeon can also directly manipulate the delivery catheter 210, advancing its distal end along the distal portion of the pre-release member 220 to approach its distal end. The boss 2111 and the slot 2211 can directly engage, enabling the reassembly of the delivery catheter 210 and the pre-release member 220. The surgeon can then manipulate the pre-release member 220 to retrieve the left atrial appendage occluder 300 back into the delivery catheter 100 for adjustment and repositioning.

[0055] In some cases, the left atrial appendage occluder 300 does not need to be retrieved into the delivery catheter 100 during adjustment, as it has already been pre-pushed to the target position. The operator can also attempt to adjust the position of the left atrial appendage occluder 300 by manipulating the pre-release element 220. To ensure the force exerted by the distal end of the pre-release element 220 on the left atrial appendage occluder 300, while preserving the flexibility of the distal end of the pre-release element 220 so that it can naturally bend along the blood vessel or cavity, the distal part of the pre-release element 220 can be made of spring coils, or the entire element can be made of spring coils. A hypotube can also be used, which facilitates the operator's manipulation and pushing of the left atrial appendage occluder 300 while also ensuring the flexibility of this part.

[0056] Conversely, the delivery catheter 210 is at least partially wound with spring coils, which reduces the stiffness of the distal portion of the delivery catheter 210, improves the ability of the delivery mechanism 200 to pass through narrow / torsional paths, and enhances the safety of intracardiac procedures. In embodiments where both the delivery catheter 210 and the pre-release member 220 are wound with spring coils, the winding directions of the spring coils are opposite, which helps to cancel out possible torques during delivery, reducing torque accumulation on the delivery mechanism 200 and maintaining the sensitivity of the distal end of the delivery mechanism 200 to torque and delivery force transmission.

[0057] In one specific embodiment, see Figure 4 The pre-release component 220 is made of a thiocyanate tube, and the tube wall has several sets of perforated holes 222. Each set of perforated holes 222 includes several perforated holes 2221 distributed circumferentially along the thiocyanate tube. Adjacent sets of perforated holes 222 are offset circumferentially along the thiocyanate tube, and the perforated holes 2221 of adjacent sets of perforated holes 222 overlap axially along the thiocyanate tube. This design allows the distal part of the pre-release component 220 to be flexible, its bending angle to be more controllable, and provides a certain degree of support, which is beneficial for fine-tuning the left atrial appendage occluder 300 relative to its implantation position.

[0058] Specifically, each set of perforated holes 222 includes three perforated holes 2221, all of which are arc-shaped and evenly spaced along the circumference of the waveguide. In each pair of adjacent sets of perforated holes 222, the perforated hole set 222 near the proximal end is offset by 15° in a clockwise or counterclockwise direction relative to the perforated hole set 222 near the distal end, so that the adjacent perforated holes 2221 in the two sets have axial overlap.

[0059] See Figure 1 and Figure 2 This application also provides a left atrial appendage occlusion system, including a left atrial appendage occlusion device 300 and a delivery assembly provided in any of the above embodiments, wherein the left atrial appendage occlusion device 300 has a third connecting structure (not shown) at its proximal end, which is adapted to dock with the second connecting structure 221.

[0060] Specifically, the distal end of the second connecting structure 221 is provided with a first threaded portion 2212, and the proximal end of the third connecting structure is provided with a second threaded portion (not shown) that matches the first threaded portion 2212. The first threaded portion 2212 is either an internal thread or an external thread, and the second threaded portion is either an internal thread or an external thread. Thus, after confirming that the left atrial appendage occluder 300 is implanted correctly, the operator can easily and quickly separate and release the left atrial appendage occluder 300 by rotating the pre-release member 220.

[0061] Specifically, the left atrial appendage occluder 300 includes an occlusion portion 310, which comprises a first fixing member 311, a first mesh body 312, and a second fixing member. The first mesh body 312 is woven from multiple elastic metal wires, with its distal end bound within the first fixing member 311 and its proximal end bound within the second fixing member (not shown), forming a closed structure. The left atrial appendage occluder 300 may further include a covering portion 320, which comprises a third fixing member, a second mesh body 321, and a fourth fixing member. The second mesh body 321 is woven from multiple elastic metal wires, with its distal end bound within the third fixing member (not shown) and its proximal end bound within the fourth fixing member (not shown), forming a closed structure. The third fixing member and the second fixing member are connected to achieve the connection between the occlusion portion 310 and the covering portion 320. The third connection structure is located at the proximal end of the fourth fixing member, enabling the connection between the left atrial appendage occluder 300 and the delivery assembly. The orthographic projection of the covering portion 320 onto the blocking portion 310 covers the blocking portion 310. Thus, when the blocking portion 310 is implanted into the left atrial appendage, the covering portion 320 can cover the opening of the left atrial appendage, blocking blood flow between the left atrial appendage and the left atrium.

[0062] Preferably, the third and second fixation components are detachably connected, allowing the surgeon to select appropriate occlusion portion 310 and covering portion 320 for use according to the anatomical structure of the left atrial appendage, thus forming a more flexible and comprehensive implantation device specification. This increases the applicability of the left atrial appendage occluder 300, enabling it to cope with different occlusion strategies and providing high flexibility.

[0063] In the above embodiments, the descriptions of each embodiment have different focuses. For parts that are not described in detail or recorded in a certain embodiment, please refer to the relevant descriptions of other embodiments.

[0064] It should be noted that the above embodiments can be freely combined as needed. The above are merely preferred embodiments of this application. It should be pointed out that for those skilled in the art, several improvements and modifications can be made without departing from the principles of this application, and these improvements and modifications should also be considered within the scope of protection of this application.

Claims

1. A delivery assembly for delivering, retrieving, and releasing a left atrial appendage occluder, characterized in that, include: A delivery conduit having a first internal lumen extending axially; A pushing mechanism is adapted to pass through the first inner cavity, and the distal end of the pushing mechanism is detachably connected to the left atrial appendage occluder; The pushing mechanism includes a pushing catheter and a pre-release member. The pushing catheter has a second inner cavity that extends axially, and the pre-release member passes through the second inner cavity. The distal end of the pushing catheter is provided with a first connecting structure, and the distal end of the pre-release member is provided with a second connecting structure. The proximal end of the second connecting structure is detachably connected to the first connecting structure, and the distal end of the second connecting structure is detachably connected to the left atrial appendage occluder. When the second connecting structure is connected to the first connecting structure, the first connecting structure restricts the second connecting structure from rotating radially and moving axially relative to the push catheter, so as to push the left atrial appendage occluder to the target position; When the second connecting structure separates from the first connecting structure, the pushing mechanism pre-releases the left atrial appendage occluder; when the second connecting structure separates from the left atrial appendage occluder, the pushing mechanism releases the left atrial appendage occluder.

2. The conveying assembly according to claim 1, characterized in that, One of the first connecting structure and the second connecting structure is provided with a slot, and the other of the first connecting structure and the second connecting structure is provided with a boss. The boss is adapted to be engaged in the slot to restrict the relative rotation and axial movement between the first connecting structure and the second connecting structure.

3. The conveying assembly according to claim 2, characterized in that, The first connecting structure has a boss at its distal end and a slot at its proximal end. The distal end face of the boss is adapted to abut against the bottom of the slot so that the push conduit can push the pre-release member. The two side walls of the boss in the circumferential direction are adapted to abut against the two side walls of the slot in the circumferential direction to restrict the relative rotation between the first connecting structure and the second connecting structure. The number of protrusions is three, and the three protrusions are evenly spaced along the circumference of the first connecting structure.

4. The conveying assembly according to claim 1, characterized in that, The delivery conduit is at least partially wound with spring coils; and / or, The pre-release component is at least partially formed by a spring coil, or the pre-release component is made of a hyaluronic acid tube.

5. The conveying assembly according to claim 4, characterized in that, The pre-release component is a sodium hypochlorite tube, and the wall of the sodium hypochlorite tube is provided with a number of hollow hole groups, the hollow hole groups including a number of hollow holes distributed along the circumference of the sodium hypochlorite tube. Two adjacent sets of hollow holes are offset along the circumference of the hyaluronic acid tube, and the hollow holes of two adjacent sets of hollow holes overlap along the axial direction of the hyaluronic acid tube.

6. The conveying assembly according to claim 5, characterized in that, The perforated hole group includes three perforated holes, and the three perforated holes are evenly spaced along the circumference of the sodium hypochlorite tube; and / or, The offset angle between two adjacent perforated hole groups is 15°, and the perforated hole groups on the sodium hypochlorite tube are all offset in a clockwise or counterclockwise direction.

7. A left atrial appendage occlusion system, characterized in that, include: Left atrial appendage occluder and delivery assembly as described in any one of claims 1-6; The left atrial appendage occluder has a third connecting structure at its proximal end, which is suitable for docking with the second connecting structure.

8. The left atrial appendage occlusion system according to claim 7, characterized in that, The second connecting structure has a first threaded portion at its distal end, and the third connecting structure has a second threaded portion at its proximal end that is adapted to the first threaded portion; the first threaded portion is one of internal thread and external thread, and the second threaded portion is the other of internal thread and external thread.

9. The left atrial appendage occlusion system according to claim 7, characterized in that, The left atrial appendage occluder includes an occlusion part, which includes a first fixing member, a first mesh body, and a second fixing member. The distal end of the first mesh body is constricted within the first fixing member, and the proximal end of the first mesh body is constricted within the second fixing member.

10. The left atrial appendage occlusion system according to claim 7, characterized in that, The left atrial appendage occlusion device further includes a covering portion, the covering portion comprising a third fixing member, a second mesh body, and a fourth fixing member, wherein the distal end of the second mesh body is constricted within the third fixing member, and the proximal end of the second mesh body is constricted within the fourth fixing member, wherein the third fixing member and the second fixing member are connected, and the third connecting structure is disposed at the proximal end of the fourth fixing member; and, The orthographic projection of the covering portion onto the sealing portion covers the sealing portion.

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