Wood vinegar traditional Chinese medicine composition for treating vulva lichen sclerosus as well as preparation method and application of wood vinegar traditional Chinese medicine composition

Abstract

The invention relates to the technical field of traditional Chinese medicine, in particular to a pyroligneous liquid traditional Chinese medicine composition for treating vulva lichen sclerosus and a preparation method and application of the pyroligneous liquid traditional Chinese medicine composition. The wood vinegar traditional Chinese medicine composition comprises a Yanghe decoction and Chinese angelica four-inverse concentrated extract, a common cnidium fruit and pepper extract, a suberect spatholobus stem and red sage root water extract, zedoary turmeric oil and refined wood vinegar. After the compound lotion provided by the invention is used for one month, the cure rate of the vulva lichen sclerosus reaches 90% or above, and the effective rate reaches 100%.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and in particular to a wood vinegar-based traditional Chinese medicine composition for treating vulvar lichen sclerosus, its preparation method, and its application. Background Technology

[0002] Vulvar lichen sclerosus, also known as lichen sclerosus, is a chronic disease characterized by degeneration and pigmentation changes in the skin and mucous membranes of the female vulva. It is a stubborn and difficult-to-treat gynecological condition with an unknown cause. The International Vulvar Research Association defines it as chronic vulvar dystrophy. Vulvar lichen sclerosus manifests as degeneration of the vulvar skin and mucous membranes, along with localized pigmentation changes. The most common symptom is persistent vulvar pruritus, which is most pronounced during sleep and often causes severe itching, disrupting sleep. In some patients, the condition progresses, leading to atrophy and adhesions at the clitoris and vaginal opening, causing urinary difficulties and dyspareunia. Scratching due to intense itching can cause local skin fissures and ulcers, significantly impacting the patient's quality of life. If patients delay treatment due to mild or absent symptoms, or if treatment is ineffective, the disease can progress and lead to numerous sequelae, commonly including scarring at the clitoris and vaginal opening adhesions and stenosis. Patients often experience sexual psychological disorders. Clinically, most medications used to treat vulvar lichen sclerosus are potent corticosteroids, such as clobetasol propionate. Long-term use can cause side effects such as skin atrophy, decreased elasticity, and telangiectasia. Therefore, a traditional Chinese medicine combination is needed for the treatment of vulvar lichen sclerosus. Summary of the Invention

[0003] To address the aforementioned problems, this invention provides a wood vinegar-based traditional Chinese medicine composition for treating vulvar lichen sclerosus, along with its preparation method and application. The wood vinegar-based traditional Chinese medicine composition provided by this invention can effectively treat vulvar lichen sclerosus.

[0004] To achieve the above objectives, the present invention provides the following technical solution:

[0005] This invention provides a traditional Chinese medicine composition of wood vinegar for treating vulvar lichen sclerosus, comprising the following components in parts by weight: 50-60 parts of Yanghe Decoction combined with concentrated extract of Angelica sinensis and Angelica dahurica, 10-15 parts of extract of Cnidium monnieri and Zanthoxylum bungeanum, 8-10 parts of extract of Spatholobus suberectus and Salvia miltiorrhiza, 3-5 parts of Curcuma zedoaria oil, and 20-25 parts of refined wood vinegar.

[0006] Preferably, the wood vinegar herbal composition comprises the following components in parts by weight: 55 parts of Yanghe Decoction combined with concentrated extract of Angelica sinensis and Angelica dahurica, 12 parts of extract of Cnidium monnieri and Zanthoxylum bungeanum, 9 parts of extract of Spatholobus suberectus and Salvia miltiorrhiza, 4 parts of Curcuma zedoaria oil, and 22 parts of refined wood vinegar.

[0007] Preferably, the preparation method of the Yanghe Decoction combined with the concentrated extract of Angelica sinensis and Angelica dahurica includes the following steps:

[0008] 1) Mix Rehmannia glutinosa, cinnamon, ephedra, deer antler glue, white mustard seed, ginger charcoal, angelica sinensis, cinnamon twig, white peony root, asarum and raw licorice to obtain a mixture;

[0009] The mass ratio of Rehmannia glutinosa, cinnamon, ephedra, deer antler glue, white mustard seed, ginger charcoal, angelica sinensis, cinnamon twig, white peony root, asarum and raw licorice is 30:3:2:9:6:2:12:9:9:3:5;

[0010] 2) After mixing the mixture described in step 1) with water, decoct for 50-60 minutes, filter, and concentrate the obtained filtrate to a density of 1.25-1.30 g / ml to obtain Yanghe Decoction combined with Angelica sinensis and Angelica sinensis concentrated extract.

[0011] The mass ratio of the mixture to water is 1:10.

[0012] Preferably, the preparation method of the Cnidium monnieri and Zanthoxylum bungeanum co-extract in step 1) includes the following steps: supercritical carbon dioxide extraction at a temperature of 50-60℃ and a pressure of 25-30MPa, CO2 circulating extraction for 2-3 hours, and concentration of the extract to a density of 0.8-1.0g / ml to obtain the Cnidium monnieri and Zanthoxylum bungeanum co-extract.

[0013] Preferably, the preparation method of the aqueous extract of chicken blood vine and salvia miltiorrhiza in step 1) includes the following steps: mixing chicken blood vine, salvia miltiorrhiza and water, decocting, filtering, and obtaining the filtrate as the aqueous extract of chicken blood vine and salvia miltiorrhiza;

[0014] The mass ratio of chicken blood vine, salvia miltiorrhiza and water is 1-2:5-7:60-90.

[0015] Preferably, the preparation method of the refined wood vinegar in step 1) includes the following steps:

[0016] Rice straw is pyrolyzed, and the gas produced by pyrolysis is condensed to obtain crude wood vinegar. The pyrolysis conditions include: a temperature of 400-500℃, a heating rate of 5-8℃ / min, and a holding time of 2-3 hours.

[0017] The crude wood vinegar solution is left to stand for more than one month, and the middle and upper layers of liquid are refined wood vinegar solution.

[0018] The present invention also provides a method for preparing the wood vinegar traditional Chinese medicine composition described in the above technical solution, wherein the Yanghe Decoction is combined with the concentrated extract of Angelica sinensis and Scutellaria baicalensis, the extract of Cnidium monnieri and Zanthoxylum bungeanum, the extract of Spatholobus suberectus and Salvia miltiorrhiza, Curcuma zedoaria oil and refined wood vinegar to obtain the wood vinegar traditional Chinese medicine composition.

[0019] The present invention also provides the application of the wood vinegar traditional Chinese medicine composition described in the above technical solution in the preparation of a drug for treating vulvar lichen sclerosus.

[0020] The present invention also provides a compound wash for treating vulvar lichen sclerosus, comprising the following components in parts by weight: 43.5 parts of the wood vinegar traditional Chinese medicine composition described in the above technical solution, 5 parts of glycerin, 50 parts of water, 1 part of chitosan and 0.5 parts of phenoxyethanol.

[0021] The present invention also provides a sanitary napkin dressing for treating vulvar lichen sclerosus, characterized in that the sanitary napkin dressing has the following structure from top to bottom: a contact layer, a drug sustained-release layer, an isolation layer and a backing layer;

[0022] The method for preparing the drug sustained-release layer is as follows: the wood vinegar traditional Chinese medicine composition described in the above technical solution is mixed with carbomer 940 to obtain the drug sustained-release layer;

[0023] The mass ratio of the herbal composition in the wood vinegar solution to carbomer 940 is 98.5:1.5;

[0024] The drug loading capacity of the drug-releasing layer on the contact layer is 0.5 g / cm³. 2 .

[0025] The beneficial effects of this invention are:

[0026] In this invention, Yanghe Decoction combined with concentrated extracts of Angelica sinensis and Sini Decoction warms the Yang, dispels cold, and invigorates blood circulation; Cnidium monnieri and Zanthoxylum bungeanum extracts have antibacterial and antipruritic properties and improve microcirculation; Spatholobus suberectus and Salvia miltiorrhiza water extracts invigorate blood circulation, remove blood stasis, and resist fibrosis; Curcuma zedoaria oil breaks up blood stasis, eliminates masses, and softens keratin; refined wood vinegar promotes penetration, regulates pH (3.5-4.5), synergistically fights bacteria, and enhances the permeability of the stratum corneum. These combined ingredients are used to treat vulvar lichen sclerosus. After one month of use of the compound wash provided by this invention, the cure rate of vulvar lichen sclerosus reached over 90%, and the effective rate reached 100%. Detailed Implementation

[0027] This invention provides a traditional Chinese medicine composition of wood vinegar for treating vulvar lichen sclerosus, comprising the following components in parts by weight: 50-60 parts of Yanghe Decoction combined with concentrated extract of Angelica sinensis and Scutellaria baicalensis, 10-15 parts of co-extract of Cnidium monnieri and Zanthoxylum bungeanum, 8-10 parts of aqueous extract of Spatholobus suberectus and Salvia miltiorrhiza, 3-5 parts of Curcuma zedoaria oil, and 20-25 parts of refined wood vinegar. Preferably, the wood vinegar composition comprises the following components in parts by weight: 55 parts of Yanghe Decoction combined with concentrated extract of Angelica sinensis and Scutellaria baicalensis, 12 parts of co-extract of Cnidium monnieri and Zanthoxylum bungeanum, 9 parts of aqueous extract of Spatholobus suberectus and Salvia miltiorrhiza, 4 parts of Curcuma zedoaria oil, and 22 parts of refined wood vinegar. In this invention, the Yanghe Decoction combined with concentrated extract of Angelica sinensis and Scutellaria baicalensis warms the yang, dispels cold, and invigorates blood circulation. In this invention, the co-extract of Cnidium monnieri and Zanthoxylum bungeanum has antibacterial and antipruritic properties and improves microcirculation. In this invention, the aqueous extract of Spatholobus suberectus and Salvia miltiorrhiza invigorates blood circulation, removes blood stasis, and has anti-fibrotic effects. In this invention, the Curcuma zedoaria oil breaks up blood stasis, eliminates masses, and softens the stratum corneum. In this invention, the refined wood vinegar promotes penetration, adjusts pH (3.5-4.5), synergistically fights bacteria, and enhances the permeability of the stratum corneum. In this invention, the xanthocyanin in the Cnidium monnieri and Zanthoxylum bungeanum co-extract increases the drug's transdermal penetration rate by 3.2 times in synergistic effect with the refined wood vinegar. In this invention, the Spatholobus suberectus polysaccharide in the Spatholobus suberectus and Salvia miltiorrhiza water extract repairs mucosal damage.

[0028] In this invention, the preferred method for preparing the concentrated extract of Yanghe Decoction combined with Angelica sinensis and Scutellaria baicalensis includes the following steps: 1) Mixing Rehmannia glutinosa, Cinnamomum cassia, Ephedra sinica, Cervi cornu colla, Sinapis alba, Zingiber officinale charcoal, Angelica sinensis, Cinnamomum cassia twig, Paeonia lactiflora, Asarum heterotropoides, and Glycyrrhiza uralensis to obtain a mixture; the mass ratio of Rehmannia glutinosa, Cinnamomum cassia, Ephedra sinica, Cervi cornu colla, Sinapis alba, Zingiber officinale charcoal, Angelica sinensis, Cinnamomum cassia twig, Paeonia lactiflora, Asarum heterotropoides, and Glycyrrhiza uralensis is 30:3:2:9:6:2:12:9:9:3:5; 2) After mixing the mixture obtained in step 1) with water, decoct for 50-60 minutes, filter, and concentrate the obtained filtrate to a density of 1.25-1.30 g / ml (at room temperature 25℃) to obtain the concentrated extract of Yanghe Decoction combined with Angelica sinensis and Scutellaria baicalensis; the mass ratio of the mixture to water is 1:10.

[0029] In this invention, the preferred method for preparing the co-extract of Cnidium monnieri and Zanthoxylum bungeanum includes the following steps: supercritical carbon dioxide extraction at a temperature of 50-60°C and a pressure of 25-30 MPa, CO2 circulating extraction for 2-3 hours, and concentration of the extract to a density of 0.8-1.0 g / ml (at room temperature of 25°C) to obtain the co-extract of Cnidium monnieri and Zanthoxylum bungeanum.

[0030] In this invention, the preferred method for preparing the aqueous extract of *Spatholobus suberectus* and *Salvia miltiorrhiza* includes the following steps: mixing *Spatholobus suberectus*, *Salvia miltiorrhiza* and water, decocting, filtering, and obtaining the filtrate as the aqueous extract of *Spatholobus suberectus* and *Salvia miltiorrhiza*; the mass ratio of *Spatholobus suberectus*, *Salvia miltiorrhiza* and water is 1-2:5-7:60-90.

[0031] In this invention, the preferred method for preparing the refined wood vinegar includes the following steps: pyrolyzing rice straw and condensing the gas produced by pyrolysis to obtain crude wood vinegar; the pyrolysis conditions include: a temperature of 400-500℃, a heating rate of 5-8℃ / min, and holding for 2-3 hours; and allowing the obtained crude wood vinegar to stand for more than one month, with the upper and middle layers being the refined wood vinegar.

[0032] This invention also provides a method for preparing the wood vinegar traditional Chinese medicine composition described in the above technical solution. The method involves mixing the Yanghe Decoction with concentrated extracts of Angelica sinensis and Cnidium monnieri, extracts of Cnidium monnieri and Zanthoxylum bungeanum, extracts of Spatholobus suberectus and Salvia miltiorrhiza, Curcuma zedoaria oil, and refined wood vinegar to obtain the wood vinegar traditional Chinese medicine composition. This invention does not impose any particular limitation on the mixing process; uniform mixing is sufficient.

[0033] The present invention also provides the application of the wood vinegar traditional Chinese medicine composition described in the above technical solution in the preparation of a drug for treating vulvar lichen sclerosus.

[0034] This invention also provides a compound wash for treating vulvar lichen sclerosus, comprising the following components in parts by weight: 43.5 parts of the wood vinegar herbal composition described in the above technical solution, 5 parts of glycerin, 50 parts of water, 1 part of chitosan, and 0.5 parts of phenoxyethanol. This invention does not specify a particular method for preparing the compound wash; conventional mixing is sufficient. This invention also does not specify a particular method for using the compound wash; patients with vulvar lichen sclerosus can simply wash the affected area after evening cleansing.

[0035] This invention also provides a sanitary napkin dressing for treating vulvar lichen sclerosus. The sanitary napkin dressing has the following structure from top to bottom: a contact layer, a drug-releasing layer, a release layer, and a backing layer. The drug-releasing layer is prepared by mixing the wood vinegar herbal composition described in the above technical solution with carbomer 940 to obtain the drug-releasing layer. The mass ratio of the wood vinegar herbal composition to carbomer 940 is 98.5:1.5. The drug loading of the drug-releasing layer on the contact layer is 0.5 g / cm³. 2 In this invention, the contact layer is made of pure cotton non-woven fabric, which is breathable and skin-friendly. In this invention, the drug-releasing layer continuously releases the drug for 8-12 hours. In this invention, the isolation layer is a microporous PE membrane, preventing leakage. In this invention, the backing layer is medical pressure-sensitive adhesive + release paper for secure application. This invention does not specifically limit the preparation method of the sanitary napkin dressing; conventional methods are acceptable. This invention does not specifically limit the usage method of the sanitary napkin dressing; conventional methods are acceptable.

[0036] To further illustrate the present invention, the following detailed description is provided in conjunction with embodiments, but these should not be construed as limiting the scope of protection of the present invention.

[0037] Example 1

[0038] A traditional Chinese medicine composition for treating vulvar lichen sclerosus, comprising the following components in parts by weight: 55 parts of Yanghe Decoction combined with concentrated extract of Angelica sinensis and Angelica dahurica, 12 parts of extract of Cnidium monnieri and Zanthoxylum bungeanum, 9 parts of extract of Spatholobus suberectus and Salvia miltiorrhiza, 4 parts of Curcuma zedoaria oil, and 22 parts of refined wood vinegar.

[0039] The preparation method of Yanghe Decoction combined with concentrated extract of Angelica sinensis and Angelica dahurica includes the following steps:

[0040] 1) Mix Rehmannia glutinosa, cinnamon, ephedra, deer antler glue, white mustard seed, ginger charcoal, angelica sinensis, cinnamon twig, white peony root, asarum, and raw licorice root to obtain a mixture; the mass ratio of Rehmannia glutinosa, cinnamon, ephedra, deer antler glue, white mustard seed, ginger charcoal, angelica sinensis, cinnamon twig, white peony root, asarum, and raw licorice root is 30:3:2:9:6:2:12:9:9:3:5;

[0041] 2) After mixing the mixture from step 1) with water, decoct for 50-60 minutes, filter, and concentrate the filtrate to a density of 1.30 g / ml to obtain Yanghe Decoction combined with Angelica sinensis and Angelica sinensis concentrated extract; the mass ratio of the mixture to water is 1:10.

[0042] The preparation method of the co-extract of Cnidium monnieri and Zanthoxylum bungeanum is as follows: supercritical carbon dioxide extraction is performed at a temperature of 60℃ and a pressure of 25MPa. CO2 is circulated for 3 hours. The extract is concentrated to a density of 1.0g / ml to obtain the co-extract of Cnidium monnieri and Zanthoxylum bungeanum.

[0043] The preparation method of the aqueous extract of chicken blood vine and salvia miltiorrhiza is as follows: chicken blood vine, salvia miltiorrhiza and water are mixed and decocted, filtered, and the filtrate is the aqueous extract of chicken blood vine and salvia miltiorrhiza; the mass ratio of chicken blood vine, salvia miltiorrhiza and water is 1:5:60.

[0044] The preparation method of refined wood vinegar includes the following steps: pyrolyzing rice straw, condensing the gas produced by pyrolysis to obtain crude wood vinegar; the pyrolysis conditions include: temperature of 500℃, heating rate of 8℃ / min, and holding for 2 hours; the obtained crude wood vinegar is left to stand for 1 month, and the middle and upper liquid is refined wood vinegar.

[0045] A method for preparing a wood vinegar traditional Chinese medicine composition for treating vulvar lichen sclerosus involves mixing the above-mentioned amounts of Yanghe Decoction with concentrated extracts of Angelica sinensis and Scutellaria baicalensis, extracts of Cnidium monnieri and Zanthoxylum bungeanum, extracts of Spatholobus suberectus and Salvia miltiorrhiza, Curcuma zedoaria oil, and refined wood vinegar to obtain the wood vinegar traditional Chinese medicine composition.

[0046] Example 2

[0047] A traditional Chinese medicine composition for treating vulvar lichen sclerosus, comprising the following components in parts by weight: 50 parts of Yanghe Decoction combined with concentrated extract of Angelica sinensis and Angelica dahurica, 15 parts of extract of Cnidium monnieri and Zanthoxylum bungeanum, 8 parts of extract of Spatholobus suberectus and Salvia miltiorrhiza, 5 parts of Curcuma zedoaria oil, and 20 parts of refined wood vinegar.

[0048] The rest is the same as in Example 1.

[0049] Example 3

[0050] A traditional Chinese medicine composition for treating vulvar lichen sclerosus, comprising the following components in parts by weight: 60 parts of Yanghe Decoction combined with concentrated extract of Angelica sinensis and Angelica dahurica, 10 parts of extract of Cnidium monnieri and Zanthoxylum bungeanum, 810 parts of extract of Spatholobus suberectus and Salvia miltiorrhiza, 3 parts of Curcuma zedoaria oil, and 25 parts of refined wood vinegar.

[0051] The rest is the same as in Example 1.

[0052] Example 4

[0053] A compound wash for treating vulvar lichen sclerosus comprises the following components in parts by weight: 43.5 parts of the wood vinegar herbal composition prepared in Example 1, 5 parts of glycerin, 50 parts of water, 1 part of chitosan, and 0.5 parts of phenoxyethanol. The components are mixed to obtain the compound wash.

[0054] Example 5

[0055] A compound wash for treating vulvar lichen sclerosus comprises the following components in parts by weight: 43.5 parts of the wood vinegar herbal composition prepared in Example 2, 5 parts of glycerin, 50 parts of water, 1 part of chitosan, and 0.5 parts of phenoxyethanol. The components are mixed to obtain the compound wash.

[0056] Example 6

[0057] A compound wash for treating vulvar lichen sclerosus comprises the following components in parts by weight: 43.5 parts of the wood vinegar herbal composition prepared in Example 3, 5 parts of glycerin, 50 parts of water, 1 part of chitosan, and 0.5 parts of phenoxyethanol. The components are mixed to obtain the compound wash.

[0058] Application Example 1

[0059] 1. In 2024, 300 patients with vulvar lichen sclerosus, aged 30 to 50 years, were randomly divided into 3 groups of 100 patients each, and used the compound lotion prepared in Examples 4 to 6 respectively.

[0060] 2. Observation indicators

[0061] Clinical symptoms include itching, pain, burning sensation, and dyspareunia.

[0062] Physical signs: skin atrophy, hypopigmentation, chapped skin, erosion, etc.

[0063] 3. Treatment methods

[0064] Patients with lichen sclerosus were cleansed at night with a compound wash once a night for one month, and the treatment results were recorded.

[0065] 4. Efficacy evaluation criteria

[0066] Cure: Clinical symptoms and signs completely disappear, and the skin recovers.

[0067] Significant effect: Clinical symptoms and signs are significantly improved, and the area of ​​skin lesions is reduced by more than 50%.

[0068] Effective: Clinical symptoms and signs improved, and the area of ​​skin lesions decreased by 20-50%.

[0069] Ineffective: No significant improvement in clinical symptoms and signs, and a reduction in the area of ​​skin lesions of less than 20%.

[0070] Table 1. Treatment efficacy of vulvar lichen sclerosus

[0071]

[0072]

[0073] As can be seen from Table 1, after one month of use of the compound wash provided by this invention, the cure rate of vulvar lichen sclerosus reached over 90%, and the effectiveness rate reached 100%.

[0074] Although the above embodiments have provided a detailed description of the present invention, they are only some embodiments of the present invention, and not all embodiments. People can obtain other embodiments based on these embodiments without creative effort, and these embodiments all fall within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine composition using wood vinegar for treating vulvar lichen sclerosus, characterized in that, The product comprises the following components in parts by weight: 50-60 parts of Yanghe Decoction combined with concentrated extract of Angelica sinensis and Sini Decoction, 10-15 parts of extract of Cnidium monnieri and Zanthoxylum bungeanum, 8-10 parts of water extract of Spatholobus suberectus and Salvia miltiorrhiza, 3-5 parts of Curcuma zedoaria oil, and 20-25 parts of refined wood vinegar.

2. The wood vinegar traditional Chinese medicine composition according to claim 1, characterized in that, The traditional Chinese medicine composition comprises the following components in parts by weight: 55 parts of Yanghe Decoction combined with concentrated extract of Angelica sinensis and Sini Decoction, 12 parts of extract of Cnidium monnieri and Zanthoxylum bungeanum, 9 parts of extract of Spatholobus suberectus and Salvia miltiorrhiza, 4 parts of Curcuma zedoaria oil, and 22 parts of refined wood vinegar.

3. The wood vinegar traditional Chinese medicine composition according to claim 1 or 2, characterized in that, The preparation method of the Yanghe Decoction combined with the concentrated extract of Angelica sinensis and Angelica dahurica includes the following steps: 1) Mix Rehmannia glutinosa, cinnamon, ephedra, deer antler glue, white mustard seed, ginger charcoal, angelica sinensis, cinnamon twig, white peony root, asarum and raw licorice to obtain a mixture; The mass ratio of Rehmannia glutinosa, cinnamon, ephedra, deer antler glue, white mustard seed, ginger charcoal, angelica sinensis, cinnamon twig, white peony root, asarum and raw licorice is 30:3:2:9:6:2:12:9:9:3:5; 2) After mixing the mixture described in step 1) with water, decoct for 50-60 minutes, filter, and concentrate the obtained filtrate to a density of 1.25-1.30 g / ml to obtain Yanghe Decoction combined with Angelica sinensis and Angelica sinensis concentrated extract. The mass ratio of the mixture to water is 1:

10.

4. The wood vinegar traditional Chinese medicine composition according to claim 1 or 2, characterized in that, Step 1) The preparation method of the Cnidium monnieri and Zanthoxylum bungeanum co-extract includes the following steps: supercritical carbon dioxide extraction is performed at a temperature of 50-60℃ and a pressure of 25-30MPa. CO2 is circulated for extraction for 2-3 hours, and the extract is concentrated to a density of 0.8-1.0g / ml to obtain the Cnidium monnieri and Zanthoxylum bungeanum co-extract.

5. The wood vinegar traditional Chinese medicine composition according to claim 1 or 2, characterized in that, Step 1) The preparation method of the aqueous extract of chicken blood vine and salvia miltiorrhiza includes the following steps: chicken blood vine, salvia miltiorrhiza and water are mixed and decocted, filtered, and the filtrate is the aqueous extract of chicken blood vine and salvia miltiorrhiza. The mass ratio of chicken blood vine, salvia miltiorrhiza and water is 1-2:5-7:60-90.

6. The wood vinegar traditional Chinese medicine composition according to claim 1 or 2, characterized in that, Step 1) The preparation method of the refined wood vinegar includes the following steps: Rice straw is pyrolyzed, and the gas produced by pyrolysis is condensed to obtain crude wood vinegar. The pyrolysis conditions include: a temperature of 400-500℃, a heating rate of 5-8℃ / min, and a holding time of 2-3 hours. The crude wood vinegar solution is left to stand for more than one month, and the middle and upper layers of liquid are refined wood vinegar solution.

7. A method for preparing the wood vinegar traditional Chinese medicine composition according to any one of claims 1 to 6, characterized in that, The Yanghe Decoction was combined with concentrated extracts of Angelica sinensis and Sini Decoction, extracts of Cnidium monnieri and Zanthoxylum bungeanum, extracts of Spatholobus suberectus and Salvia miltiorrhiza, Curcuma zedoaria oil, and refined wood vinegar to obtain a wood vinegar traditional Chinese medicine composition.

8. The use of the wood vinegar traditional Chinese medicine composition according to any one of claims 1 to 6 in the preparation of a drug for treating vulvar lichen sclerosus.

9. A compound wash for treating vulvar lichen sclerosus, characterized in that, The components include the following parts by weight: The wood vinegar traditional Chinese medicine composition according to any one of claims 1 to 6 comprises 43.5 parts, 5 parts, 50 parts, 1 part, chitosan, and 0.5 parts, respectively.

10. A sanitary napkin dressing for treating vulvar lichen sclerosus, characterized in that, The structure of the sanitary napkin dressing is as follows: from top to bottom, it consists of a contact layer, a drug sustained-release layer, an isolation layer, and a backing layer; The method for preparing the drug sustained-release layer is as follows: the wood vinegar traditional Chinese medicine composition according to any one of claims 1 to 6 is mixed with carbomer 940 to obtain the drug sustained-release layer; The mass ratio of the herbal composition in the wood vinegar solution to carbomer 940 is 98.5:1.5; The drug loading capacity of the drug-releasing layer on the contact layer is 0.5 g / cm³. 2 .

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