Anti-allergic eye composition

Abstract

An anti-allergic product containing: at least 0.01% w / w of a plant extract wherein the plant extract is selected from the group consisting of tea leaf extract, melaleuca alternifolia leaf oil and mixtures thereof; an amphiphilic preservative and a glycolipid. The eyelid cleansing composition is configured to alleviate redness, discomfort, and irritation in and around the eyelid.

Description

Technical Field

[0001] This invention generally relates to anti-allergy products for relieving symptoms associated with eyelid allergies. Background Technology

[0002] Eye health refers to the eye and its associated structures, such as the eyelids. The eyelids are important for overall eye health because they protect the eye from dangers such as nearby objects or airborne contaminants like pollen, dust particles, or other foreign objects. The eyelids contain essential glands; the lacrimal glands and meibomian glands, which produce the tear film layer, crucial for healthy eyes. When a person blinks, a new tear film forms, and tears are distributed across the cornea, lubricating the surface of the eye. This blinking action also "washes away" foreign objects from the eye.

[0003] However, eyelids are susceptible to skin allergies and bacterial infections. Seasonal allergies can also cause redness, swelling, itching, and irritation of the eyes and eyelids. Allergy eye drops can relieve eye symptoms, but they cannot relieve irritated eyelids. Therefore, a product that can alleviate eyelid allergy symptoms is needed. Summary of the Invention

[0004] According to one embodiment, the anti-allergy composition comprises at least 0.01% w / w of a plant extract, said plant extract being selected from the group consisting of: tea tree (Camellia sinesis) leaf extract, Melaleuca alternifolia leaf oil, and mixtures thereof. The composition also comprises glycolipids, an amphiphilic preservative, and water. In one embodiment, the glycolipid is a sphingolipid selected from the group consisting of: sphingolipids, ceramides, glycerophospholipids, sphingolipid derivatives, and combinations thereof.

[0005] In an exemplary embodiment, the sphingolipid is selected from the group consisting of: sphingosine, dihydrosphingosine, phytosphingosine, phytosphingosine salts, tetraacetylphytosphingosine, N-acetylphytosphingosine, and mixtures thereof. The sphingolipid is preferably in the range of 0.1% to 0.3% w / w.

[0006] In one or more embodiments, the preservative is present in the range of 0.01% to 5% w / w. In one specific embodiment, the preservative is laurylamine oxide.

[0007] According to one embodiment, the anti-allergy composition further comprises at least one polyol having 2-12 carbon atoms. The at least one polyol may be a 1,2-diol selected from the group consisting of 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, and mixtures thereof. Embodiments of the composition comprise at least one polyol in the range of 0.01% to 5% w / w.

[0008] Exemplary embodiments of the anti-allergy composition further comprise one or more surfactants present in the range of 0.1% to 20% w / w. Of said one or more surfactants, the first surfactant has an HLB value of 10-18, and the second surfactant (if present) has an HLB value of 10-18 or 5-10. In one specific embodiment, the surfactant comprises decyl glucoside and polysorbate 20.

[0009] In one embodiment, the anti-allergy composition further comprises a foam stabilizer. The foam stabilizer is preferably a polyethylene glycol diester of methyl glucose and fatty acids.

[0010] In some embodiments of the anti-allergy composition, the pH is in the range of 3.5 to 6.5, the refractive index is about 1.33 to 1.35, and the specific gravity is about 0.99 to 1.01.

[0011] Other embodiments of the anti-allergy composition include one or more moisturizers, emollients, humectants, and lubricants, as well as one or more skin conditioning agents, antioxidants, soothing agents, cooling agents, viscosity modifiers, and nutrients.

[0012] According to one embodiment, the anti-allergy composition is combined with a matrix that can be impregnated by a desired amount of the composition, and wherein the matrix impregnated by the composition is configured as a disposable product.

[0013] In an exemplary embodiment, the anti-allergy composition comprises 0.1-0.3% phytosphingosine hydrochloride, 0.01-5% hexanediol, 0.01-5% octanediol, 0.1-20% polysorbate 20, 0.1-20% decyl glucoside, at least 0.01% tea tree oil, at least 0.01% green tea extract, 0.01-5% laurylamine oxide, and water to 100%. The pH is in the range of 3.5 to 6.5, the refractive index is about 1.33 to 1.35, and the specific gravity is about 0.99 to 1.0.

[0014] In one embodiment, redness, discomfort, and irritation at the application site can be relieved by gently applying the anti-allergy composition to the surface of the eyelid and the surrounding eye area. The composition can be formulated as a no-rinse or rinse-off formulation. Detailed Implementation

[0015] The terms and phrases “invention,” “the present invention,” “the invention,” and similar terms and phrases used herein are non-limiting and are not intended to limit the subject matter to any single embodiment, but rather to include all possible embodiments described.

[0016] As used herein, unless otherwise stated, all weight percentages (wt.%) are based on the total weight percentage of the anti-allergy composition. Furthermore, unless otherwise stated, all percentages of components are based on a total amount equal to 100% by weight.

[0017] The products and methods described herein may “comprise any component or step disclosed in the specification,” “consistently comprise any component or step disclosed in the specification,” or “comprise any component or step disclosed in the specification.” As used in this specification and claims, the terms “comprising” (and any form of inclusion, such as “comprise” and “comprises”), “having” (and any form of having, such as “have” and “has”), “including” (and any form of inclusion, such as “includes” and “include”), or “containing” (and any form of containing, such as “contains” and “contain”) are inclusive or open-ended and may include components / steps of the invention, but do not exclude other components or steps described herein. When used in conjunction with the term “comprising” in the claims and / or specification, the use of the terms “a” or “an” may mean “one,” but it is also consistent with the meanings of “one or more,” “at least one,” and “more than one.” As used herein, "consistent with..." means that the invention may include other components / steps besides those listed in the claims, provided that these additional components do not substantially alter the essential and novel characteristics of the claimed invention. Typically, additives may be absent entirely or present only in trace amounts. However, up to about 10% by weight of materials that could substantially alter the essential and novel characteristics of the invention may be included, provided that the utility of the composition is maintained (relative to the extent of utility).

[0018] All ranges described herein include endpoint values, including those describing a range "between" two numerical values. Terms such as "about," "usually," and "substantially" should be interpreted as modifying a term or value so that it is not an absolute value. These terms will be defined by the context as understood by those skilled in the art and by the terms they modify. In a non-limiting embodiment, these terms are defined as within 1%, more preferably within 0.1%, and most preferably within 0.01%. The term "substantially" and its variations are defined as having a substantial but not necessarily exact meaning as understood by those skilled in the art.

[0019] As used herein, the term "effective amount" of a composition refers to an amount sufficient to elicit a desired biological response. As will be understood by those skilled in the art, the effective amount of a substance can vary depending on factors such as the desired biological endpoint, the patient, etc. In some embodiments, the therapeutically effective amount of a composition is an amount sufficient to treat, suppress, alleviate, prevent, and / or delay the onset of one or more symptoms of eyelid allergy when administered to a subject who has or is susceptible to the disease, condition, and / or symptom. The terms "treat" or "alleviate," or any variations thereof, include a qualitative or quantitative reduction of allergic symptoms. For example, an effective amount / therapeutically effective amount of a composition for treating eyelid allergy is an amount that reduces, improves, alleviates, suppresses, prevents, delays the onset of one or more symptoms or features associated with eyelid allergy, reduces their severity, and / or reduces their incidence.

[0020] Anti-allergy compositions may include anti-inflammatory agents, antimicrobial agents, antifungal agents, and antiirritants. In one embodiment, the composition is an eyelid cleanser for removing pollen, contaminants, and allergens from the eyelids and eyelid margins / eyes / periorbital area. The composition may be formulated to prevent or relieve eyelid allergy-like symptoms, namely redness, itching, roughness, or inflammation of the eyelids or surrounding area. The composition contains effective amounts of one or more plant extracts, lipophilic or amphiphilic agents, preservatives with antimicrobial activity, and suitable solvents or carriers.

[0021] The plant extract may be selected from the group consisting of: tea tree (green tea) leaf extract, Melaleuca alternifolia (tea tree) leaf oil, citrus, chamomile, and combinations thereof. In one specific embodiment, the plant extract may include a mixture of green tea extract and tea tree leaf oil. The selected plant extract will contain an effective amount (i.e., at least 0.01% w / w of polyphenols and terpenoids) of these compounds. Such plant extracts typically possess antimicrobial, antifungal, and / or anti-inflammatory activities.

[0022] For example, certain tea tree or green tea leaf extracts have been shown to contain polyphenols. These polyphenols may include flavanol derivatives. Flavanol derivatives may include catechins, epigallocatechin, and epigallocatechin gallate. Green tea extracts generally have antioxidant properties, protecting the skin from free radical damage. Furthermore, some green tea extracts contain anti-inflammatory agents that can reduce skin inflammation. Some green tea extracts have also been shown to have moisturizing effects and, as inhibitors of epidermal collagenase (a collagen reductase that breaks down collagen), help maintain firm and elastic skin.

[0023] Tea tree oil, or tea leaf oil, is typically obtained from the Australian natural plant Melaleuca alternifolia through steam distillation and contains approximately one hundred components, such as terpenes, terpenes, and related derivatives and combinations. More specifically, tea tree oil usually contains monoterpenes, sesquiterpenes, and related alcohols.

[0024] An important aspect of this composition relates to its antimicrobial activity, which is typically provided by one or more antimicrobial agents. In one embodiment, the composition comprises glycolipids. The glycolipids are selected from the group consisting of sphingolipids, ceramides, glycerophospholipids, sphingolipid derivatives, and combinations thereof. In one embodiment, a sphingosine base is selected from the group consisting of sphingosine, dihydrosphingosine, phytosphingosine, phytosphingosine salts, tetraacetylphytosphingosine, N-acetylphytosphingosine, and mixtures thereof. In a specific embodiment, the sphingosine base comprises about 0.1% to about 0.3% of phytosphingosine and / or phytosphingosine hydrochloride (HCl) as an active ingredient. In one embodiment, the composition comprises about 0.2% phytosphingosine hydrochloride. Phytosphingosine and phytosphingosine hydrochloride can inhibit the growth of microorganisms on the skin, reduce skin redness and inflammation, and are active at very low concentrations. PSG HCl helps prevent skin moisture loss, promotes collagen synthesis while reducing its degradation, and soothes inflamed skin. It can also exhibit skin-protective and anti-inflammatory properties at concentrations as low as 0.1%.

[0025] A preferred embodiment of the composition comprises a preservative with effective antimicrobial activity. One preservative with significant antimicrobial properties is laurylamine oxide. Laurylamine oxide is an ideal amphiphilic preservative for use in the ocular region because it is compatible with a variety of surfactant systems, including anionic, cationic, amphoteric, nonionic systems, and various combinations thereof. In one or more embodiments, the preservative is selected from the group consisting of laurylamine oxide, myristamine oxide, combinations of laurylamine oxide and myristamine oxide, N,N-dialkylamine oxides having a long alkyl chain between C10 and C18, and mixtures thereof. In one embodiment, the N,N-dialkyl group is preferably methyl. Furthermore, the N,N-dialkylamine oxide having a long alkyl chain between C10 and C18 is preferably an oleodimethylamine oxide.

[0026] The composition further comprises a polyol having 2-12 carbon atoms. Preferably, at least one 1,2-diol compound is included for the dissolution of glycolipids. Due to the antimicrobial-enhancing activity of 1,2-diols, they may be included in the composition. Preferred 1,2-diols are selected from the group consisting of: 1,2-hexanediol, a synthetic preservative with broad-spectrum antimicrobial activity; and 1,2-octanediol (also known as octanediol), another active substance with both preservative and antimicrobial functions.

[0027] The anti-allergy composition may also contain a mixture of one or more surfactants to promote the dissolution of tea tree oil. Various surfactants may be included in the composition to achieve the desired foaming and / or cleaning abilities. The inclusion of surfactants will enhance the composition's ability to dissolve and remove oils, antigens, debris, and peeling skin. Preferred surfactants have foaming capabilities, including nonionic or amphoteric surfactants with HLB values ​​of 10-18. If more than one surfactant is used, at least one surfactant should have an HLB value of 10-18, and the other surfactants should have an HLB value of 10-18 or 5-10.

[0028] Suitable surfactants can include amphoteric surfactants, anionic surfactants, and nonionic surfactants. Suitable amphoteric surfactants include, but are not limited to, alkyl dimethyl betaine, alkylamide betaine, sulfobetaine, and imidazoline amphoteric surfactants. Suitable anionic surfactants include, but are not limited to, fatty alcohol sulfates, α-oleic acid glyceride sulfonates, sulfosuccinates, sarcosinates, phosphate esters, and carboxylates. Suitable nonionic surfactants include, but are not limited to, alkanolamides, ethoxylated amides, esters, alkylated alcohols, alkyl polyglucosides, amine oxides, sorbitan esters, and ethoxylates.

[0029] One or more surfactants may comprise, but are not limited to, sorbitan esters (e.g., Span 20 or sorbitan monolaurate), polyethylene glycol (PEG) modified surfactants (e.g., polysorbate 20, Brij 52, PEG-75 lanolin), modified phospholipids, modified sugars (e.g., alkyl polyglucosides, alkyl glucosides, fatty acid glucosamides), amine oxides, and / or block copolymers, such as poloxamer (Pluronic F120) or tyloxapol. The total concentration of surfactants will be in the range of 0.1-20% w / w in the final formulation, but more preferably in the range of 0.5-5%. The addition of surfactants enhances the cleaning ability of the composition and imparts foaming properties. Foam is considered to have the best cleaning effect.

[0030] The preferred surfactant system of this composition comprises decyl glucoside and polysorbate 20 to promote the dissolution of tea tree oil. This system is optimized to enhance the foaming properties of the composition and the delivery of the active ingredient to the skin surface. The HLB values ​​of decyl glucoside and polysorbate 20 are 12.8 and 16.7, respectively.

[0031] Although optional, foam stabilizers may also be incorporated into the composition and may include, but are not limited to, polyethylene glycol diesters of methyl glucose and fatty acids. The fatty acids may be selected from the group consisting of oleic acid, stearic acid, lauric acid, caprylic acid, and capric acid. Preferably, one or more foam stabilizers comprise PEG-120 methyl glucose dioleate.

[0032] One or more humectants, emollients, humectants, or lubricants are also commonly incorporated into the composition and are generally referred to herein as humectants. Suitable humectants are propylene glycol, glycerin, polyethylene glycol (e.g., PEG300, 400, 600) or commonly used liquid polyols, argan oils and derivatives, rose water (flower extract), cucumber extract, fruit extracts, sodium alginate, hyaluronic acid, diglycerides, triglycerides, PEG-75 lanolin, mineral oil, and silicone oil.

[0033] Other optional components may also be added to the composition, up to a maximum of 5% w / w of the composition. These optional components include compounds such as skin conditioning agents (e.g., D-panthenol), antioxidants (e.g., vitamin E and its derivatives, green tea extract, vitamin C and its derivatives), anti-irritant / soothing agents (e.g., allantoin, aloe vera, tea tree oil), cooling agents (e.g., sorbitol, xylitol, menthol, thymol), viscosity modifiers (e.g., carboxymethyl cellulose, hydroxypropyl methylcellulose, carbomer), and nutrients (e.g., minerals, vitamins, amino acids, or peptides).

[0034] An exemplary embodiment of the composition is shown in Table 1. This embodiment has a pH value in the range of 3.5 to 6.5, a refractive index of about 1.33 to 1.35, and a specific gravity of about 0.99 to 1.01. Those skilled in the art will recognize that the properties of the composition can be adjusted within a range while maintaining physiological compatibility with the eye. The given ranges reflect optimal values ​​for the following components and are not limitations on all possible embodiments of the invention.

[0035] Table 1.

[0036]

[0037] This composition is substantially non-irritating to the eyes. Advantageously, the composition does not contain astringents such as zinc or zinc salts.

[0038] The composition may be selected from the group consisting of: solutions, aerosols, foams, gels, sprays, lotions, suspensions, emulsions, ointments, and combinations thereof.

[0039] In one embodiment, the composition can be combined with a suitable matrix to form an anti-allergy product for cleaning the eyelids. The matrix can be impregnated with a clinically effective amount of the composition. The matrix can be a wipe, fabric pad, or small wet wipe, or any suitable material capable of absorbing the desired amount of the composition. The term "pad" refers to a thick sheet of fabric capable of containing or absorbing the composition. The fabric can be a lint-free fabric, such as rayon or other suitable materials. In some embodiments, the fabric pad can be a cotton pad. The fabric pad may include a textured surface.

[0040] The anti-allergy product can be configured as a single-use product. The anti-allergy product can be provided in sealed packaging. One to 100 such packages can be provided in a single container.

[0041] In another embodiment, a method of treating eyelid allergies includes providing the anti-allergy product disclosed herein. The method further includes gently applying the product to the surface of the eyelid and / or the area surrounding the eyelid to relieve redness, discomfort, and irritation within and around the eyelid. The composition can be formulated to leave no residue. The composition can be left on the eyelid or rinsed off with water. The composition can cleanse and remove foreign matter and debris, including microorganisms such as bacteria or allergens on the eyelid, from the application site. It can also induce foaming (which contributes to the cleansing ability of the formulation) and prevent allergies, as well as promote anti-inflammatory and anti-redness effects on the eyelid and eyelid margins.

[0042] The present invention may include unlisted components and other components (e.g., biological gloves), or may consist substantially of unlisted components and other components (e.g., biological gloves).

[0043] In one or more embodiments, the anti-allergic ophthalmic composition can be prepared by first preparing a glycolipid mixture. This involves adding a predetermined amount of 1,2-diol to a mixing container to promote the dissolution of the glycolipid mixture. An antimicrobial glycolipid is then added to the same container. The mixture is subsequently mixed at 500 RPM for 30 minutes, or until the glycolipid is completely dissolved into a clear solution. Heating the mixture to completely dissolve the glycolipid is not required.

[0044] In a separate container, add purified water to approximately 90% of the final batch weight. Next, add the dissolved sugar and fat mixture to the purified water. Rinse the initial mixing container with purified water as needed and transfer the contents to a new container. The mixing process begins at 500 RPM.

[0045] During mixing, add surfactants, plant extracts, preservatives, and any other additional ingredients described herein to the mixture. Rinse all containers and utensils with purified water and transfer them to the current mixing vessel. Continue mixing until homogeneous. Finally, adjust the mixture to the final weight with purified water and mix for another 30 minutes to ensure homogeneity.

[0046] The potential for ocular irritation was assessed using the non-animal testing method EpiOcular. 100% of the anti-allergy formulation scored approximately "0" in the Draize ocular irritation test, and the irritation category was classified as "non-irritating." A Human Repeat Insult Patch Test was conducted on a panel of 50 human subjects. Ultimately, no potential for skin irritation or sensitization was found in the stated anti-allergy formulation.

[0047] The stability of the anti-allergy composition was evaluated for over 18 months at room temperature and over 6 months at 40°C. Under both conditions, the pH, refractive index, and specific gravity of the composition remained unchanged compared to their initial values. Furthermore, throughout the study, the composition maintained its clear to yellow appearance without any visible particulate matter formation. Antimicrobial efficacy was tested on the 18-month-old sample at room temperature according to USP51, and the results were satisfactory.

[0048] It will be apparent to those skilled in the art that various modifications and variations can be made to this invention without departing from its scope or spirit. Other embodiments of the invention will be readily apparent to those skilled in the art in light of the specification and examples disclosed herein. The specification and examples are considered exemplary only. Claims (as amended under Article 19 of the Treaty) 1. An anti-allergy composition comprising: (i) at least 0.01% w / w of plant extract, wherein the plant extract is selected from the group consisting of tea leaf extract, Melaleuca alternifolia leaf oil and mixtures thereof; (ii) glycolipids; (iii) An amphiphilic preservative, wherein the amphiphilic preservative is selected from the group consisting of: laurylamine oxide, myristamine oxide, combinations of laurylamine oxide and myristamine oxide, N,N-dialkylamine oxides having a long alkyl chain between C10 and C18, and mixtures thereof; and (iv) Water. 2. The anti-allergic composition according to claim 1, wherein the glycolipid is selected from the group consisting of: sphingolipids, ceramides, glycerophospholipids, sphingolipid derivatives, and combinations thereof. 3. The anti-allergic composition according to claim 2, wherein the glycolipid is a sphingolipid selected from the group consisting of: sphingosine, dihydrosphingosine, phytosphingosine, phytosphingosine salt, tetraacetyl phytosphingosine, N-acetyl phytosphingosine, and mixtures thereof. 4. The anti-allergy composition according to claim 3, wherein the sphingolipid is in the range of 0.1% to 0.3% w / w. 5. The anti-allergic composition according to claim 1, wherein the amphiphilic preservative is present in the range of 0.01% to 5% w / w. 6. The anti-allergy composition according to claim 1, further comprising at least one polyol. 7. The anti-allergy composition according to claim 6, wherein the polyol has 2-12 carbon atoms. 8. The anti-allergy composition according to claim 7, wherein the polyol is a 1,2-diol selected from the group consisting of: 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, and mixtures thereof. 9. The anti-allergy composition according to claim 8, wherein the polyol is present in the range of 0.01% to 5% w / w. 10. The anti-allergy composition according to claim 1, further comprising one or more surfactants. 11. The anti-allergy composition of claim 10, wherein the one or more surfactants are present in the range of 0.1% to 20% w / w. 12. The anti-allergy composition according to claim 10, wherein the one or more surfactants comprise decyl glucoside and polysorbate 20. 13. The anti-allergy composition according to claim 10, wherein the first surfactant has an HLB value of 10 to 18. 14. The anti-allergy composition according to claim 13, wherein the second surfactant has an HLB value of 10 to 18 or 5 to 10. 15. The anti-allergy composition according to claim 1, further comprising a foam stabilizer. 16. The anti-allergy composition according to claim 15, wherein the foam stabilizer is a polyethylene glycol diester of methyl glucose and fatty acids. 17. The anti-allergy composition according to claim 1, wherein the pH is in the range of 3.5 to 6.5. 18. The anti-allergic composition according to claim 1, wherein the refractive index is about 1.33 to 1.35. 19. The anti-allergy composition according to claim 1, wherein the specific gravity is from about 0.99 to 1.01. 20. The anti-allergy composition according to claim 1, further comprising one or more humectants, emollients, humectants, and lubricants. 21. The anti-allergy composition according to claim 1, further comprising one or more skin conditioning agents, antioxidants, soothing agents, cooling agents, viscosity modifiers, and nutrients. 22. The anti-allergy composition of claim 1, wherein the composition is combined with a matrix capable of being impregnated by a desired amount of the composition. 23. The anti-allergy composition and matrix according to claim 22, wherein the matrix impregnated by the composition is configured as a disposable product. 24. An anti-allergy composition comprising: 0.1-0.3% phytosphingosine hydrochloride, 0.01-5% hexanediol, 0.01-5% octanediol, 0.1-20% polysorbate 20, 0.1-20% decyl glucoside, At least 0.01% tea tree oil, At least 0.01% green tea extract, 0.01-5% laurylamine oxide, and Add water to 100%. 25. Use of the anti-allergy composition according to claim 1 in the preparation of a medicament for treating eyelid allergies, said use comprising: Provide the anti-allergy composition according to claim 1; and Gently apply the composition to the surface of the eyelids and around the eyes. The composition is configured to reduce redness, discomfort, and irritation at the application site. 26. The use according to claim 25, wherein the anti-allergy composition is configured as a no-rinse or rinse-off composition.

Claims

1. An anti-allergy composition comprising: (i) at least 0.01% w / w of plant extract, wherein the plant extract is selected from the group consisting of tea leaf extract, Melaleuca alternifolia leaf oil and mixtures thereof; (ii) glycolipids; (iii) Amphiphilic preservatives; and (iv) Water.

2. The anti-allergic composition according to claim 1, wherein the glycolipid is selected from the group consisting of: sphingolipids, ceramides, glycerophospholipids, sphingolipid derivatives, and combinations thereof.

3. The anti-allergic composition according to claim 2, wherein the glycolipid is a sphingolipid selected from the group consisting of: sphingosine, dihydrosphingosine, phytosphingosine, phytosphingosine salt, tetraacetyl phytosphingosine, N-acetyl phytosphingosine, and mixtures thereof.

4. The anti-allergy composition according to claim 3, wherein the sphingolipid is in the range of 0.1% to 0.3% w / w.

5. The anti-allergic composition according to claim 1, wherein the amphiphilic preservative is present in the range of 0.01% to 5% w / w.

6. The anti-allergic composition according to claim 1, wherein the amphiphilic preservative is selected from the group consisting of: laurylamine oxide, myristamine oxide, combinations of laurylamine oxide and myristamine oxide, N,N-dialkylamine oxide having a long alkyl chain between C10 and C18, and mixtures thereof.

7. The anti-allergy composition according to claim 1, further comprising at least one polyol.

8. The anti-allergy composition according to claim 7, wherein the polyol has 2-12 carbon atoms.

9. The anti-allergy composition according to claim 8, wherein the polyol is a 1,2-diol selected from the group consisting of: 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, and mixtures thereof.

10. The anti-allergy composition according to claim 9, wherein the polyol is present in the range of 0.01% to 5% w / w.

11. The anti-allergy composition according to claim 1, further comprising one or more surfactants.

12. The anti-allergy composition of claim 11, wherein the one or more surfactants are present in the range of 0.1 to 20% w / w.

13. The anti-allergy composition according to claim 11, wherein the one or more surfactants comprise decyl glucoside and polysorbate 20.

14. The anti-allergy composition according to claim 11, wherein the first surfactant has an HLB value of 10 to 18.

15. The anti-allergy composition according to claim 14, wherein the second surfactant has an HLB value of 10 to 18 or 5 to 10.

16. The anti-allergy composition according to claim 1, further comprising a foam stabilizer.

17. The anti-allergy composition according to claim 16, wherein the foam stabilizer is a polyethylene glycol diester of methyl glucose and fatty acids.

18. The anti-allergy composition according to claim 1, wherein the pH is in the range of 3.5 to 6.

5.

19. The anti-allergic composition according to claim 1, wherein the refractive index is about 1.33 to 1.

35.

20. The anti-allergy composition according to claim 1, wherein the specific gravity is from about 0.99 to 1.

01.

21. The anti-allergy composition according to claim 1, further comprising one or more moisturizers, emollients, humectants, and lubricants.

22. The anti-allergy composition according to claim 1, further comprising one or more skin conditioning agents, antioxidants, soothing agents, cooling agents, viscosity modifiers, and nutrients.

23. The anti-allergy composition of claim 1, wherein the composition is combined with a matrix capable of being impregnated by a desired amount of the composition.

24. The anti-allergy composition and matrix according to claim 23, wherein the matrix impregnated by the composition is configured as a disposable product.

25. An anti-allergy composition comprising: 0.1-0.3% phytosphingosine hydrochloride, 0.01-5% hexanediol, 0.01-5% octanediol, 0.1-20% polysorbate 20, 0.1-20% decyl glucoside, At least 0.01% tea tree oil, At least 0.01% green tea extract, 0.01-5% laurylamine oxide, and Add water to 100%.

26. Use of the anti-allergy composition according to claim 1 in the preparation of a medicament for treating eyelid allergies, said use comprising: Provide the anti-allergy composition according to claim 1; and Gently apply the composition to the surface of the eyelids and around the eyes. The composition is configured to reduce redness, discomfort, and irritation at the application site.

27. The use according to claim 26, wherein the anti-allergy composition is configured as a no-rinse or rinse-off composition.

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