Multi-mode physiotherapy system integrating ion release and electromagnetic stimulation

Abstract

The invention relates to the technical field of physiotherapy, in particular to a multi-mode physiotherapy system integrating ion release and electromagnetic stimulation. The system comprises a biological feedback sensing module, an intelligent control module, a space-time cooperative control module, a multi-channel ion release module, a multi-band electromagnetic generation module and a self-adaptive optimization module. Firstly, skin impedance, blood flow and temperature parameters are collected by the system, and a collaborative strategy is generated through multi-parameter analysis of an intelligent control module; the time-space cooperative control module synchronously adjusts the ion release and electromagnetic field excitation time sequence; the multi-channel ion release module realizes quantitative release of multiple types of ions by utilizing microfluidics; the multi-band electromagnetic generation module outputs low-frequency, medium-frequency and high-frequency programmable electromagnetic fields; the adaptive optimization module dynamically corrects treatment parameters based on the electrophysiological feedback. According to the system, multi-modal fusion of iontophoresis and electromagnetic stimulation is realized, and the accuracy and individualization level of treatment are improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of physiotherapy, in particular to a multi-modal physiotherapy system integrating ion release and electromagnetic stimulation. BACKGROUND

[0002] With the development of rehabilitation medicine and physical therapy, iontophoresis and electromagnetic stimulation have gradually become important auxiliary means for tissue repair, inflammation relief and nerve regulation. However, a single mode often cannot adapt to complex and variable physiological environments, and the treatment effect varies.

[0003] In the prior art, iontophoresis devices mostly rely on constant current or simple time control, lacking real-time response to changes in skin impedance and blood flow; although electromagnetic stimulation devices can provide different frequency bands and field strengths, they often present independent control modes from ion release, making it difficult to overlap the action areas and insufficient in time sequence coordination, and the synergistic effect is limited. At the same time, some devices do not introduce a dynamic feedback mechanism, making it difficult to optimize parameters according to the electrophysiological response of individual patients, and are prone to cause excessive stimulation or insufficient effect. SUMMARY

[0004] The present application provides a multi-modal physiotherapy system integrating ion release and electromagnetic stimulation, which can realize multi-modal synergistic effect to improve the precision and individualization level of treatment.

[0005] To achieve the above-mentioned purpose, the present application provides the following technical solutions: A multi-modal physiotherapy system integrating ion release and electromagnetic stimulation, comprising: a biofeedback sensing module for collecting skin impedance, microcirculation blood flow and tissue temperature parameters of a patient; an intelligent control module for receiving the skin impedance, microcirculation blood flow and tissue temperature parameters, calculating synergistic treatment parameters through multi-parameter coupling analysis, and generating a synergistic treatment strategy; a spatiotemporal synergistic control module for synchronously controlling the timing of ion release and the timing of electromagnetic field excitation according to the synergistic treatment strategy, and accurately overlapping the ion release area and the electromagnetic field action area through spatial positioning technology, and outputting ion release control instructions and electromagnetic field excitation control instructions; a multi-channel ion release module for quantitatively releasing different types of treatment ions to the treatment area through microfluidic technology according to the ion release control instructions; a multi-frequency electromagnetic generation module for generating programmable electromagnetic fields covering low, medium and high frequencies according to the electromagnetic field excitation control instructions, and realizing spatially controllable electromagnetic field distribution through an electrode array; an adaptive optimization module for monitoring changes in the electrophysiological response of the tissue during treatment, evaluating the strength of ion-electromagnetic synergistic effect, and adjusting the subsequent synergistic treatment strategy according to the treatment effect feedback.

[0006] As a preferred technical solution of the present application, the multi-parameter coupling analysis comprises: A coupling model of skin impedance, microcirculation blood flow and tissue temperature parameters is established, and when the skin impedance change rate exceeds a preset threshold and the tissue temperature is lower than a safe upper limit, a time stamp is recorded as the starting point of the ion permeation window period; The electromagnetic field intensity parameter is adjusted according to the comprehensive evaluation results of the tissue temperature parameter and the blood flow parameter, and when the temperature parameter exceeds the upper limit value, the electromagnetic field intensity is multiplied by a first preset coefficient, and when the blood flow parameter is simultaneously lower than a preset threshold, the electromagnetic field intensity is multiplied by a second preset coefficient; The skin impedance change rate and the blood flow parameter growth rate are comprehensively analyzed, and when both satisfy the preset conditions, the tissue metabolic active state is determined and the synergistic treatment parameter is output.

[0007] As a preferred technical solution of the present application, the generation of the synergistic treatment strategy comprises: combination analysis of the tissue metabolic active state, the temperature safe state and the impedance change state, setting corresponding treatment parameter gears for different state combinations, each gear containing specific ion release concentration multiple, electromagnetic field intensity coefficient and action time proportion, forming a multi-gear synergistic treatment strategy.

[0008] As a preferred technical solution of the present application, the synchronization control of the timing of ion release and the timing of electromagnetic field excitation comprises: A low-frequency electromagnetic field pretreatment stage before ion release, a medium-frequency pulse electromagnetic field synchronization stage during ion release, and a high-frequency electromagnetic field maintenance stage after ion release; A three-stage timing control protocol, and the time interval between stages is dynamically adjusted according to the skin impedance change rate; The timing controller receives the time adjustment parameter in the synergistic treatment strategy, and generates a timing instruction table containing the starting time and duration of each stage.

[0009] As a preferred technical solution of the present application, the spatial positioning technology comprises: Obtaining three-dimensional coordinate data of the skin surface, and establishing a spatial coordinate system of the treatment area; Calculating the geometric center coordinates and boundary coordinates of the ion release area; Detecting the current position coordinates of the electromagnetic field electrode, and calculating the geometric center coordinates of the electromagnetic field action area; Comparing the spatial deviation of the ion release area center coordinates and the electromagnetic field action area center coordinates, and generating a position adjustment instruction when the deviation exceeds a preset threshold; According to the position adjustment instruction, the electrode position parameter is corrected, and the spatial coincidence coefficient is recalculated.

[0010] As a preferred technical solution of the present application, the multi-channel ion release module is configured to perform the following steps: The ion release control instruction is parsed to obtain ion type identification, release concentration parameters and release time parameters; According to the ion type identification, the corresponding ion storage channel is selected, and the volume flow rate of each channel ion solution is calculated; The opening angle and opening time of the microfluidic valve are set, and the opening and closing state of each channel is controlled according to the time sequence of the release time parameter; The flow sensor data of each channel is monitored, and the valve opening angle is adjusted when the deviation between the actual flow rate and the set flow rate exceeds the allowable range; The cumulative release amount of each channel is recorded, and the ion release of the corresponding channel is stopped when the cumulative amount reaches the preset threshold.

[0011] As a preferred technical solution of the present application, the multi-frequency electromagnetic generation module is configured to perform the following steps: The electromagnetic field excitation control instruction is parsed to obtain frequency band selection parameters, field strength amplitude parameters and waveform type parameters; According to the frequency band selection parameters, the basic frequency and modulation method of the signal generator are determined, and the driving signal of the corresponding frequency band is generated; According to the field strength amplitude parameter, the gain coefficient of the power amplifier is adjusted, and electromagnetic field excitation signals of different intensities are output; According to the spatial coordinate parameters, the phase difference and amplitude ratio of each electrode are calculated, and the excitation parameter table of the electrode array is generated; The corresponding excitation signal is loaded into each electrode in the electrode array in sequence to form a spatially distributed controllable electromagnetic field.

[0012] As a preferred technical solution of the present application, the evaluation of the intensity of ion-electromagnetic synergistic effect includes: The product of ion release amount and electromagnetic field intensity is calculated as the synergistic effect intensity index; The change amplitude of electrophysiological parameters before and after treatment is measured, and the quantitative relationship between the synergistic effect intensity index and the improvement degree of electrophysiology is established; The difference between the current patient's electrophysiological improvement degree and the standard improvement degree is compared, and the individual response deviation coefficient is calculated; The effect evaluation result containing the synergistic effect intensity and the individual response deviation coefficient is output.

[0013] As a preferred technical solution of the present application, the subsequent synergistic treatment strategy is adjusted according to the treatment result feedback, which includes: The treatment parameters are corrected in proportion according to the individual response deviation coefficient; When the individual response deviation coefficient is positive, the treatment intensity parameter of the next cycle is reduced by a proportional factor; When the individual response deviation coefficient is negative, the treatment intensity parameter for the next cycle is increased by a proportional factor. The adjustment range of ion concentration parameters and electromagnetic field parameters is dynamically adjusted according to the response characteristics of different individuals.

[0014] The beneficial effects of this invention are: 1. This invention proposes a spatiotemporal coordinated control concept, achieving precise synchronization between ion release timing and electromagnetic field excitation timing through a three-stage timing control protocol, and utilizing spatial positioning technology to precisely overlap the ion release area and the electromagnetic field action area. Unlike existing technologies where iontophoresis and electromagnetic therapy are independent or simply superimposed, this invention achieves precise coordination in both temporal and spatial dimensions, significantly improving the efficiency of ion transmembrane transport, breaking through the limitations of traditional single treatment modes, and producing a synergistic effect far exceeding the simple summation of individual technologies.

[0015] 2. This invention innovatively establishes a multi-parameter coupled analysis model of skin impedance, microcirculatory blood flow, and tissue temperature. Combined with an adaptive optimization algorithm for individual response deviation coefficients, it constructs a complete closed-loop control system from biofeedback sensing to dynamic adjustment of treatment strategies. Compared with existing fixed-parameter open-loop control technologies, this invention can intelligently adjust the synergistic treatment strategy based on the patient's individual physiological characteristics and real-time treatment response, achieving truly personalized and precise treatment. This significantly improves the success rate of treatment for complex cases, while ensuring the safety and continuous effectiveness of the treatment process through intelligent monitoring throughout. Attached Figure Description

[0016] The accompanying drawings are provided to further illustrate the invention and form part of the specification. They are used in conjunction with embodiments of the invention to explain the invention and do not constitute a limitation thereof. In the drawings: Figure 1 This is a schematic diagram of the structure of a multimodal physiotherapy system integrating ion release and electromagnetic stimulation according to the present invention; Figure 2 This is a schematic diagram of the process of a multimodal physiotherapy system integrating ion release and electromagnetic stimulation according to the present invention. Detailed Implementation

[0017] The preferred embodiments of the present invention will be described below with reference to the accompanying drawings. It should be understood that the preferred embodiments described herein are for illustration and explanation only and are not intended to limit the present invention.

[0018] Example 1: As Figure 1 As shown, the present invention discloses a multimodal physiotherapy system integrating ion release and electromagnetic stimulation, comprising: The biofeedback sensing module collects parameters such as patient skin impedance, microcirculation blood flow, and tissue temperature. Specifically, electrodes are arranged on the skin surface of the treatment area, and the electrodes are connected with impedance detection circuit. The detection circuit applies a stable alternating excitation signal to the skin and measures the voltage response of the skin surface in real time. The processing unit calculates the skin impedance parameters according to the ratio of the voltage to the excitation signal, and updates within a fixed sampling period. An optical probe is placed on the skin surface adjacent to the electrodes, the probe emits a low-intensity laser beam to the skin, and receives the reflected light. After photoelectric conversion and signal processing, parameters related to microcirculation blood flow velocity and perfusion are obtained, forming continuous blood flow dynamic data. A temperature sensor is arranged on the surface of the treatment area, the sensor is connected with amplification and conversion circuit, the detected temperature change is converted into an electric signal, and transmitted to the processing unit. The processing unit corrects and filters the temperature signal to obtain stable tissue temperature parameters. The processing unit collects and synchronizes the skin impedance, blood flow and temperature data under the control of a unified clock, ensuring that the three types of parameters correspond consistently on the time axis. The synchronized data is output in the form of a unified data packet, transmitted to the intelligent control module for subsequent multi-parameter coupling analysis.

[0019] Through the above steps, the biofeedback sensing module can stably and synchronously obtain real-time parameters of skin impedance, microcirculation blood flow and tissue temperature, ensuring the accuracy and continuity of the input data, and providing a reliable physiological basis for the generation of subsequent collaborative treatment strategies.

[0020] The intelligent control module receives the skin impedance, microcirculation blood flow and tissue temperature parameters, calculates the collaborative treatment parameters through multi-parameter coupling analysis, and generates the collaborative treatment strategy; Further, the multi-parameter coupling analysis includes: A coupling model of the skin impedance, microcirculation blood flow and tissue temperature parameters is established, and when the skin impedance change rate exceeds a preset threshold and the tissue temperature is lower than a safe upper limit, a time stamp is recorded as the starting point of the ion permeation window period; The electromagnetic field intensity parameter is adjusted according to the comprehensive evaluation results of the tissue temperature parameter and the blood flow parameter, and when the temperature parameter exceeds the upper limit value, the electromagnetic field intensity is multiplied by a first preset coefficient, and when the blood flow parameter is lower than a preset threshold value at the same time, the electromagnetic field intensity is multiplied by a second preset coefficient; The skin impedance change rate and the blood flow parameter growth rate are comprehensively analyzed, and when both satisfy the preset conditions, the tissue metabolic active state is determined and the collaborative treatment parameters are output.

[0021] Further, the generation of the collaborative treatment strategy includes: combination analysis of the tissue metabolic active state, the temperature safe state and the impedance change state, setting corresponding treatment parameter gears for different state combinations, each gear containing specific ion release concentration multiple, electromagnetic field intensity coefficient and action time proportion, forming a multi-gear collaborative treatment strategy.

[0022] Specifically, the intelligent control module first calculates the synergistic treatment parameters through multi-parameter coupling analysis, and then generates the synergistic treatment strategy based on these parameters. After the treatment is started, the intelligent control module continuously receives the three-way data of skin impedance, microcirculation blood flow and tissue temperature through the internal bus, and adds a timestamp to each record with a unified clock. To ensure the continuity of subsequent coupling calculations, the module maintains a sliding buffer, removes abnormal data that exceeds the preset physiological range, fills in the short-time missing data using time axis linear interpolation, aligns them according to the timestamp, and forms three-way synchronized original time series.

[0023] To reduce the influence of individual differences on the determination threshold, the module extracts the baseline of the three-way signal during the stable period before treatment, and then normalizes the real-time data according to the respective baseline to obtain the impedance normalized sequence, blood flow normalized sequence and temperature normalized sequence. On this basis, the module calculates the change rate of the impedance normalized sequence, the growth rate of the blood flow normalized sequence, and generates the temperature safety state flag according to the relationship between the temperature normalized sequence and the safety upper limit.

[0024] When the impedance change rate exceeds the preset threshold and the temperature safety state is true, the module immediately records the current timestamp as the starting point of the ion permeation window period and writes it into the parameter set. Subsequently, taking the unit field strength coefficient as the initial value of the electromagnetic field strength, if the temperature detection value exceeds the safety upper limit, the coefficient is multiplied by the first preset coefficient for suppression; in the case of temperature exceeding the limit and blood flow being lower than the threshold at the same time, the second preset coefficient is multiplied to complete further suppression, and the modified electromagnetic field strength coefficient is obtained. At the same time, the module jointly determines the impedance change rate and the blood flow growth rate, and sets the tissue metabolic activity state flag when both meet the set conditions. Thus, the ion permeation window starting point, electromagnetic field strength coefficient, metabolic activity state, temperature safety state and impedance state are integrated as synergistic treatment parameters, serving as inputs for strategy generation.

[0025] The strategy generation adopts a fixed mapping method from state group to gear. The module forms a ternary state group with the metabolic activity state, temperature safety state and impedance state, and predefines a one-to-one correspondence between the state group and the gear identifier in the device software. The module looks up the gear identifier according to the current state group, and assembles the three types of control quantities corresponding to the gear to form the synergistic treatment strategy: the first is the ion release concentration multiple, which is used to determine the target concentration level of the microfluidic channel; the second is the electromagnetic field strength coefficient, which is the product of the gear corresponding coefficient and the aforementioned modified electromagnetic field strength coefficient, serving as the target field strength coefficient of electromagnetic generation; the third is the action time proportion, which is used to allocate the duration proportion of the pre-treatment, synchronization and maintenance stages in the time sequence protocol, and generate the time adjustment parameter accordingly.

[0026] To ensure the consistency of the strategy in safety and efficacy, the module performs constraint checking on the ion release concentration multiple, electromagnetic field intensity coefficient and action time ratio. If there is a case that does not meet the temperature safety state or the minimum blood perfusion requirement, the module preferentially reduces the electromagnetic field intensity coefficient and rechecks until all constraints are met. After completing the checking, the module solidifies the synergistic treatment strategy including the time adjustment parameter, ion release concentration multiple and electromagnetic field intensity coefficient into a structured instruction set, records and issues it to the space-time synergistic control module and related execution module together with the gear identification, for driving subsequent time sequence control and spatial alignment.

[0027] Through the multi-parameter coupling analysis and synergistic treatment strategy generation of the above intelligent control module, the present application realizes the transformation from traditional experience dependence to data-driven intelligent treatment, establishes a quantitative mapping relationship between physiological parameters and treatment parameters, ensures that each patient obtains an individualized optimal treatment plan, and significantly improves the intelligent level and clinical safety of multi-modal synergistic treatment.

[0028] The space-time synergistic control module synchronously controls the timing of ion release and the timing of electromagnetic field excitation according to the synergistic treatment strategy, and accurately overlaps the ion release area and the electromagnetic field action area through spatial positioning technology, and outputs ion release control instructions and electromagnetic field excitation control instructions. Further, the synchronous control of the timing of ion release and the timing of electromagnetic field excitation includes: a low-frequency electromagnetic field pretreatment stage before ion release, a medium-frequency pulsed electromagnetic field synchronous stage during ion release, and a high-frequency electromagnetic field maintenance stage after ion release; a three-stage timing control protocol, and the time interval between stages is dynamically adjusted according to the skin impedance change rate; The timing controller receives the time adjustment parameter in the synergistic treatment strategy, and generates a timing instruction table including the starting time and duration of each stage.

[0029] Specifically, first, read the synergistic treatment strategy from the intelligent control module, which includes ion release concentration multiple, electromagnetic field intensity coefficient and action time ratio. The module divides the entire treatment cycle into three stages according to the action time ratio, i.e. a low-frequency electromagnetic field pretreatment stage before ion release, a medium-frequency pulsed electromagnetic field synchronous stage during ion release, and a high-frequency electromagnetic field maintenance stage after ion release.

[0030] In the first stage, the module issues low-frequency field excitation instructions to the electromagnetic generating unit according to the pretreatment parameters in the strategy, and sets the corresponding duration. This stage is used to adjust the local tissue environment to improve the ion penetration conditions in the following stages. At the end of the stage, the module records the time stamp and checks whether the skin impedance change rate meets the preset condition. If it does, it automatically enters the second stage.

[0031] In the second stage, the timing protocol received by the module requires that ion release and electromagnetic field action remain strictly synchronized. The module issues a start instruction to the ion release unit, controls the microfluidic valve to open at a set time point, and issues an excitation instruction for the intermediate frequency pulse field to the electromagnetic generating unit. The promotion of ion transmembrane transport by the electromagnetic field makes the two actions coincide in time and produce a synergistic effect. In this stage, the module dynamically corrects the duty cycle and phase of the intermediate frequency pulse field according to the real-time feedback of the impedance change rate to ensure ion permeation efficiency. The duration of the entire stage is determined by the action time proportion in the synergistic treatment strategy.

[0032] In the third stage, the module closes the ion release channel, records the cumulative release amount of each channel, and switches the electromagnetic generating unit to a high frequency mode to enter the maintenance stage. The high frequency field action is used to stabilize the ion distribution that has entered the tissue in the early stage and maintain the metabolic activity of the tissue. The duration of this stage is directly given by the time parameter table generated by the timing controller according to the strategy.

[0033] To ensure the continuous connection of each stage, the spatiotemporal synergistic control module has a three-stage timing control protocol built in. The protocol automatically calibrates the time interval before and after the stage switching and dynamically adjusts according to the change rate of the skin impedance. When the impedance decrease rate is too fast, it indicates that the tissue has reached an appropriate permeation state, and the protocol appropriately shortens the pretreatment stage and enters the synchronization stage in advance; when the impedance decrease rate is too slow, the pretreatment time is appropriately extended to ensure that ion release begins in a more appropriate window period.

[0034] Finally, the module outputs a complete timing instruction table on a unified time axis, including the start time, duration of each stage, and corresponding electromagnetic field parameters, and issues them to the ion release module and the electromagnetic generating module. At the same time, the module also issues spatial coordinate parameters to ensure that ion release and electromagnetic field excitation are precisely controlled in both time and space dimensions, significantly improving the efficiency and stability of synergistic treatment.

[0035] Further, the spatial positioning technology comprises: acquiring three-dimensional coordinate data of the skin surface to establish a spatial coordinate system of the treatment area; calculating the geometric center coordinates and boundary coordinates of the ion release area; detecting the current position coordinates of the electromagnetic field electrodes and calculating the geometric center coordinates of the electromagnetic field action area; comparing the spatial deviation of the ion release area center coordinates and the electromagnetic field action area center coordinates, and generating a position adjustment instruction when the deviation exceeds a preset threshold; correcting the electrode position parameters according to the position adjustment instruction and recalculating the spatial coincidence coefficient.

[0036] Specifically, the role of the spatial positioning technology is to ensure the precise coincidence of the ion release area and the electromagnetic field action area in the spatial dimension, thereby further enhancing the synergistic effect of the two physical stimuli. Before the treatment starts, the system first acquires the three-dimensional coordinate information of the patient's skin surface through the surface scanning device, and establishes a spatial coordinate system for the local treatment area based on this. This coordinate system serves as the basis for all spatial calculations and is used to describe the positional relationship between the ion release device and the electromagnetic electrodes.

[0037] Subsequently, the module geometrically models the outlet position of the ion release unit, calculates the center coordinates and boundary range of the ion release area. At the same time, the current position of the electromagnetic electrode array is detected in real time by the position sensor, and based on the coordinates of each electrode, the center coordinates of the electromagnetic field action area are obtained through geometric calculation method.

[0038] After both types of areas are determined, the module compares the center coordinates. When it is found that there is a spatial deviation between the center of the ion release area and the center of the electromagnetic field action area, the module calculates the deviation vector and compares it with the preset allowed range. If the deviation exceeds the threshold, the module will generate a position adjustment instruction. This instruction is used to correct the placement parameters of the electrode array on the one hand, and to fine-tune the position of the ion release unit on the other hand, thereby gradually reducing the spatial gap between the two areas.

[0039] During the position adjustment process, the module repeatedly calculates the coincidence parameter, i.e. the spatial coincidence coefficient. Through continuous iteration, the system only allows entering the next treatment stage when the spatial coincidence coefficient reaches the qualified standard set in the strategy. This ensures that the spatial action area of ion release and the electromagnetic field excitation area are highly consistent, thereby achieving precise coupling of double stimulation in the spatial dimension. It ensures that ion release and electromagnetic field excitation achieve precise synergistic control in both time and space dimensions during the treatment process.

[0040] When the spatial positioning correction is completed, the space-time synergistic control module generates a corresponding control instruction set based on the received synergistic treatment strategy, combining the time sequence control result and the spatial positioning result, which includes ion release control instructions and electromagnetic field excitation control instructions, and is respectively sent to the multi-channel ion release module and the multi-frequency electromagnetic generation module to ensure that the synergistic treatment strategy is accurately implemented in both time and space dimensions.

[0041] The multi-channel ion release module, according to the ion release control instructions, quantitatively releases different types of therapeutic ions to the treatment area through microfluidic technology; Further, the multi-channel ion release module is configured to perform the following steps: Parsing the ion release control instructions to obtain ion type identification, release concentration parameters and release time parameters; According to the ion type identification, the corresponding ion storage channel is selected, and the volume flow rate of each channel ion solution is calculated; The opening angle and opening time of the microfluidic valve are set, and the opening and closing state of each channel is controlled according to the time sequence arrangement of the release time parameter; The flow sensor data of each channel is monitored, and when the deviation between the actual flow rate and the set flow rate exceeds the allowed range, the opening angle of the valve is adjusted; The cumulative release amount of each channel is recorded, and when the cumulative amount reaches the preset threshold, the ion release of the corresponding channel is stopped.

[0042] Specifically, the multi-channel ion release module releases ions according to the ion release control instruction issued by the space-time coordination control module, and realizes quantitative and multi-type ion delivery in the treatment area based on microfluidic technology.

[0043] After the system receives the ion release control instruction, the module parses the parameter information in the instruction, extracts the ion type identification, release concentration parameter and release time parameter. Through the identification of different types of ion identification, the module locates the corresponding ion solution channel in the internal liquid storage unit. For the selected channel, the control unit calculates the required flow rate and the duration of continuous release according to the release concentration parameter and the release time parameter.

[0044] After the flow parameter is determined, the microfluidic valve enters the regulation state, and the opening angle and opening time of the valve are set according to the calculation result. The module drives each channel valve with a time sequence signal, so that the ions are accurately released to the treatment area within a predetermined time period. Different types of ions can be released in parallel or alternately to meet the requirements of the coordinated treatment strategy for ion combination.

[0045] During the release process, the module collects the monitoring data output by the flow sensor in real time. If there is a deviation between the actual flow rate and the set flow rate, the opening angle of the valve is adjusted to realize closed-loop control, so as to ensure the accuracy and stability of ion release.

[0046] Each channel is provided with a cumulative release amount statistics function, and when the cumulative release amount reaches the preset threshold, the channel automatically enters the closed state to avoid adverse effects caused by excessive ion release. All release processes are recorded and uploaded to the system database to provide data support for subsequent treatment effect analysis and parameter optimization.

[0047] The multi-frequency electromagnetic generation module generates a programmable electromagnetic field covering low frequency, medium frequency and high frequency according to the electromagnetic field excitation control instruction, and realizes a spatially controllable electromagnetic field distribution through an electrode array; Further, the multi-frequency electromagnetic generation module is configured to perform the following steps: The frequency band selection parameter, field strength amplitude parameter and waveform type parameter are obtained by parsing the electromagnetic field excitation control instruction; The basic frequency and modulation mode of the signal generator are determined according to the frequency band selection parameter, and a driving signal corresponding to the frequency band is generated; The gain coefficient of the power amplifier is adjusted according to the field strength amplitude parameter, and an electromagnetic field excitation signal of different intensity is output; The phase difference and amplitude ratio of each electrode are calculated according to the spatial coordinate parameter, and an excitation parameter table of the electrode array is generated; The corresponding excitation signal is sequentially loaded to each electrode in the electrode array to form a spatially distributed controllable electromagnetic field.

[0048] Specifically, after the module receives the electromagnetic field excitation control instruction, it analyzes the frequency band selection parameter, field strength amplitude parameter and waveform type parameter contained therein. The analysis result is input to the signal generation unit, and the unit sets the basic frequency and modulation mode according to the frequency band selection parameter to generate a driving signal that meets the requirements of the control instruction. The driving signal can be switched or combined in the low frequency, medium frequency and high frequency range to meet the needs of different frequency bands of electromagnetic action in the collaborative treatment strategy.

[0049] After the signal generation is completed, the module transmits the driving signal to the power amplification unit. The power amplification unit directly adjusts the output power of the amplifier according to the field strength amplitude parameter to realize the output of electromagnetic field of different intensity. The amplified electromagnetic excitation signal maintains the waveform characteristics and frequency band characteristics to ensure the stability and accuracy of the field strength during treatment.

[0050] In terms of spatial distribution control, the module calculates the phase difference and amplitude ratio of each electrode in the electrode array in combination with the spatial coordinate parameter. The calculation result forms an electrode excitation parameter table, which records the driving voltage amplitude and phase angle of each electrode. The control unit loads the corresponding excitation signal to each electrode according to the parameter table, so that the electrode array forms a preset spatial electromagnetic field distribution.

[0051] During the whole electromagnetic field excitation process, the module continuously monitors the frequency stability and field strength consistency of the output signal. When the actual output deviates from the set value, the driving signal or the power amplification parameter is automatically corrected to maintain the electromagnetic field within the target range. The module also monitors the working state of the electrode array, and when a single electrode signal mismatch or abnormality occurs, the overall electromagnetic field distribution is ensured to be balanced by recalculating the phase difference and amplitude ratio.

[0052] Through the above process, the multi-frequency electromagnetic generation module can flexibly regulate the electromagnetic field in time and space dimensions, and provide reliable support for the synergistic effect of ion release and electromagnetic stimulation.

[0053] The adaptive optimization module monitors the changes in the electrophysiological response of the tissue during treatment, evaluates the strength of the ion-electromagnetic synergistic effect, and adjusts the subsequent collaborative treatment strategy according to the treatment effect feedback.

[0054] Further, the evaluating the strength of the ion-electromagnetic synergistic effect comprises: calculating the product of the ion release amount and the electromagnetic field strength as a synergistic effect strength index; measuring the change amplitude of the electrophysiological parameters before and after treatment, and establishing a quantitative relationship between the synergistic effect strength index and the electrophysiological improvement degree; comparing the difference between the current patient's electrophysiological improvement degree and the standard improvement degree, and calculating an individual response deviation coefficient; outputting an effect evaluation result containing the synergistic effect strength and the individual response deviation coefficient.

[0055] Specifically, the adaptive optimization module acquires ion release control information and electromagnetic field excitation control information at the same time, and records the ion release amount and the electromagnetic field strength parameters in real time. The processing unit performs product operation on the two, and takes the result as a preliminary index of synergistic effect strength. The larger the value of the index, the higher the degree of superposition of ion concentration and electromagnetic field stimulation in the same time window, and thus the greater the potential strength of the synergistic effect.

[0056] After obtaining the synergistic effect strength index, the module synchronously acquires the electrophysiological parameters before and after treatment, including the action potential amplitude, the action potential conduction velocity and the tissue impedance value. By calculating the difference and the proportional change before and after treatment respectively, the change amplitude of each parameter is obtained. For example, when the action potential amplitude rises and the conduction velocity accelerates after treatment, and the tissue impedance decreases, it indicates that the treatment promotes the improvement of tissue excitability and conduction. The module comprehensively calculates the weighted average value of the three types of change amplitudes, and defines the average value as the electrophysiological improvement degree as a quantitative index for measuring the treatment effect.

[0057] The module further calculates the individual response deviation. This process takes the standard improvement degree in the storage unit as a reference value, which is obtained from clinical trial data or the electrophysiological reference range of healthy individuals. The module subtracts the reference value from the current electrophysiological improvement degree of the patient to obtain a difference value, and divides the difference value by the reference value to calculate the individual response deviation coefficient. When the coefficient is positive, it indicates that the improvement amplitude is higher than the standard level, when the coefficient is negative, it indicates that it is lower than the standard level, and when the coefficient is close to zero, it indicates that it is close to the standard level. Thus, the individual response deviation coefficient can objectively reflect the sensitivity and adaptability of the patient to the ion-electromagnetic synergistic effect.

[0058] After the evaluation is completed, the module outputs the comprehensive evaluation result containing the synergistic effect strength index and the individual response deviation coefficient. The result is not only used for real-time display of treatment efficiency, but also as an input basis for subsequent adjustment of synergistic treatment strategy. Through the above-mentioned manner, the embodiment ensures that the quantitative evaluation of the synergistic effect strength is fully disclosed, avoids ambiguous description, and ensures that the step can be clearly implemented by those skilled in the art.

[0059] Further, the adjustment of the subsequent synergistic treatment strategy according to the feedback of the treatment result comprises: proportionally correcting the treatment parameters according to the individual response bias coefficient; decreasing the treatment intensity parameter of the next cycle by a proportional factor when the individual response bias coefficient is positive; increasing the treatment intensity parameter of the next cycle by a proportional factor when the individual response bias coefficient is negative; dynamically correcting the adjustment range of the ion concentration parameter and the electromagnetic field parameter according to the response characteristics of different individuals.

[0060] Specifically, the individual response bias coefficient obtained in the foregoing is received. Numerical validity check is performed on the coefficient, and abnormal mutation samples are excluded and the abnormal reasons are recorded. The checked coefficient is used as the basis for adjustment in the embodiment.

[0061] An original proportional factor is generated from the individual response bias coefficient. A single monotonic mapping relationship is used to convert the bias coefficient into the original proportional factor. The mapping rule is that the "baseline multiplier" is taken as the invariant point, and the bias coefficient is mapped to the original proportional factor by a function; when the bias coefficient is positive, the original proportional factor is less than the baseline multiplier, indicating that the treatment intensity should be proportionally reduced in the next cycle; when the bias coefficient is negative, the original proportional factor is greater than the baseline multiplier, indicating that the treatment intensity should be proportionally increased in the next cycle. The mapping function is designed to ensure monotonicity and be constrained at extreme values to avoid extreme amplification or reduction by mapping. After the original proportional factor is generated, it is sent to a smoothing module to avoid sharp fluctuations within a single cycle.

[0062] The original proportional factor is subjected to smoothing and amplitude limiting processing. A recursive smoothing filter is used to smooth the original proportional factor, and a smoothed proportional factor is output. The smoothing processing is combined with upper and lower boundary amplitude limiting rules to truncate the smoothed proportional factor, ensuring that any adjustment does not exceed the safe allowable range. The amplitude limiting rule is based on safety constraints (upper temperature limit, minimum blood perfusion, maximum change in a single cycle), and the part exceeding the limit is truncated and recorded in the log.

[0063] The smoothed proportional factor is mapped to the parameter-specific adjustment coefficient. To reflect the contribution difference of different parameters to the treatment effect, ion concentration sensitivity coefficients and electromagnetic field sensitivity coefficients are defined respectively. The adjustment coefficient of the ion concentration is equal to 1 plus the sensitivity coefficient multiplied by (smoothed proportional factor−1); the adjustment coefficient of the electromagnetic field is calculated in the same form but multiplied by the electromagnetic field sensitivity coefficient; the adjustment of the action time proportion is realized by proportionally scaling the original proportions of the three stages according to the time sensitivity coefficient and then normalizing to ensure consistency of the total time proportion of the stages. The final multiplication factor of each parameter is generated, and the candidate parameter value of the next cycle is calculated accordingly: the current parameter value is multiplied by the corresponding final multiplication factor to obtain the candidate value.

[0064] The candidate parameters are subjected to safety check and priority correction. The candidate values are checked by a safety check module to see if they meet the temperature safety state, the minimum blood perfusion, the single-cycle parameter change upper limit, and the cumulative dose limit. If the check fails, the preset priority rules are followed to make corrections: the electromagnetic field intensity is reduced first to alleviate the risk of temperature rise, and then the ion concentration and time allocation are adjusted under the premise of safety; if the safety constraints cannot be met after successive corrections, the conservative mode is triggered, a more conservative parameter set is automatically selected, and an alarm is generated for clinical personnel intervention. Any modified or replaced candidate value will be marked with the reason and the original candidate value to be modified in the record.

[0065] The module dynamically updates the ion concentration and electromagnetic field sensitivity coefficient according to the observed individual response bias coefficient in each treatment cycle, combined with the records of historical cycles. The individual response bias coefficient is used to reflect the deviation of the therapeutic effect from the baseline, and the sensitivity coefficient is used as a weight factor for parameter adjustment to determine the adjustment amplitude. The system establishes a statistical model based on multi-cycle data to evaluate the correlation between each parameter adjustment and subsequent electrophysiological improvement, and estimates the sensitivity coefficient accordingly. The update uses a smooth iteration method: the difference between the latest bias and the expected response is used to fine-tune the sensitivity coefficient, and the previous version is retained for rollback and audit.

[0066] The module monitors the individual response bias coefficient and parameter adjustment trend in consecutive cycles. If it finds that the direction frequently reverses or the amplitude is too large, it automatically reduces the single-cycle adjustment amplitude and uses a micro-step addition and subtraction method until the response stabilizes. If the therapeutic effect of multiple consecutive cycles still does not meet the standard, the strategy is marked for manual review, and further automatic enhancement is suspended. All calculation and correction steps generate logs, including input coefficients, scaling factors, candidate parameters, and correction reasons. The final parameter set that passes the check is sent to the space-time collaborative control module, and an adjustment summary is displayed on the interface for clinical review. The system supports parameter rollback, which can restore to the last generation of safe parameter set when an abnormality is detected.

[0067] This embodiment forms a technical solution that strictly and controllably maps the "individual response bias coefficient" to the next cycle treatment parameters through explicit monotonic mapping, smooth limiting, parameter-specific sensitivity coefficient, online updating, and stability control. This solution balances response speed and safety and stability, making it easy to set specific mapping curves, smoothing strategies, and safety thresholds in engineering implementation, thereby realizing individual-oriented adaptive collaborative treatment.

[0068] Embodiment Two: A hospital introduced a multi-modal physiotherapy system integrating ion release and electromagnetic stimulation for the treatment of chronic muscle pain and sports injury rehabilitation. After 3 months of clinical application, significant results were achieved.

[0069] A patient suffered from chronic neck and shoulder syndrome due to long-term desk work, with continuous pain for 8 months, VAS pain score of 8, left rotation of the neck limited to 30° (normal value about 60°), and obvious local muscle stiffness. The patient received traditional treatments such as electrotherapy and massage, but the effect was not good.

[0070] The system measured the skin impedance of trapezius muscle of the neck as 3200Ω, the microcirculation blood flow as 32PU, and the skin temperature as 33.8℃, indicating poor local circulation. A low-intensity synergistic treatment program was automatically generated, with the Na+ ion concentration set as 0.8 times the standard concentration (1.12mmol / L), the electromagnetic field intensity coefficient set as 0.8, and the treatment time including 5 minutes of pretreatment, 8 minutes of synchronization, and 7 minutes of maintenance. At the 3rd minute of ion release, the impedance was detected to decrease to 2680Ω, with a change rate of -8.7Ω / s, which was determined as an ideal penetration window, and the system immediately triggered the intermediate-frequency electromagnetic field stimulation. During the treatment, the blood flow increased to 49PU, and the temperature increased to 35.2℃. After the first treatment, the VAS score decreased to 6, and the neck activity increased to 45°. The system calculated the individual response deviation coefficient as +0.33, and determined that the patient was sensitive to the synergistic treatment. In the second treatment, the system automatically adjusted the ion concentration to 0.75 times the standard concentration, and reduced the electromagnetic field intensity to 0.75, to avoid excessive stimulation. After 5 continuous treatments, the VAS decreased to 2, the neck activity recovered to 58°, and the symptoms were basically relieved.

[0071] During the same period, another patient with similar medical history used traditional electrotherapy (fixed 50Hz, intermediate-frequency electrotherapy instrument, intensity manually adjusted, no ion introduction), and after 5 treatments, the VAS only decreased from 8 to 5, and the neck activity increased from 28° to 38°. The effect was significantly worse than that of the system.

[0072] During the 3-month application in the hospital, a total of 93 patients with chronic pain were treated. The statistical results showed that the cure rate of patients using the system of the application was significantly better than that of the control group (for example, more than doubled), the average number of treatments was reduced by about 40%, and the recurrence rate was reduced by about 70% or more. In addition, the hospital rehabilitation department statistics showed that the patient satisfaction and treatment compliance using the system of the application were significantly improved.

[0073] And after the introduction of the system, the hospital's rehabilitation department improved the patient treatment efficiency under the same conditions: the monthly average number of patients treated increased from about 120 to about 170; the daily average number of patients treated by doctors increased from 8 to about 11; the average treatment time was shortened, the waiting time was reduced, and the overall satisfaction increased by about 10% according to the satisfaction survey; medical complaints were significantly reduced. From the perspective of department income, the overall business volume increased due to the increase in the number of treatments completed per unit of time. Although the system has a higher equipment investment cost than traditional equipment, the treatment efficiency and efficacy are improved, the average treatment period is shortened, and the overall cost-benefit ratio is better. According to internal estimates, the investment can be recovered within a reasonable period at a regular usage frequency.

[0074] In addition, there are some special cases, such as a patient with diabetic peripheral neuropathy and pain, who has always had poor results with conventional physiotherapy. The skin impedance was 4500Ω and the blood flow was only 18PU during treatment. The system automatically extended the pre-treatment to 8 minutes and used a low-frequency (5Hz) electromagnetic field to promote blood vessel dilation, combined with a small dose of multiple ion releases (each interval 2 minutes). After treatment, the impedance decreased to 3200Ω and the blood flow increased to 35PU, and the pain was significantly relieved. This result shows that the system can be individually adapted to special cases.

[0075] Therefore, the system can dynamically adjust treatment parameters according to real-time physiological data of patients, achieve precise coordination of ion release and electromagnetic field action, and significantly improve treatment efficiency and patient compliance.

[0076] Finally, it should be noted that the above-described only preferred embodiments of the present application and not intended to limit the present application, although the foregoing detailed description of the application has been made, for those skilled in the art, it can still modify the technical solutions recorded in the foregoing embodiments, or make equivalent replacement for some technical features. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application shall be included within the scope of protection of the present application.

Claims

1. A multi-modal physiotherapy system integrating iontophoresis and electromagnetic stimulation, characterized in that, The method comprises the following steps: A biofeedback sensing module is used to collect skin impedance, microcirculation blood flow and tissue temperature parameters; An intelligent control module is used to receive the skin impedance, microcirculation blood flow and tissue temperature parameters, calculate the synergistic treatment parameters through multi-parameter coupling analysis, and generate a synergistic treatment strategy; A space-time synergistic control module is used to synchronize the timing of ion release and the timing of electromagnetic field excitation according to the synergistic treatment strategy, and make the ion release area and the electromagnetic field action area accurately overlap through space positioning technology, and output ion release control instructions and electromagnetic field excitation control instructions; A multi-channel ion release module is used to quantitatively release different types of treatment ions to the treatment area through microfluidic technology according to the ion release control instructions; A multi-frequency electromagnetic generation module is used to generate a programmable electromagnetic field covering low, medium and high frequencies according to the electromagnetic field excitation control instructions, and realize a spatially controllable electromagnetic field distribution through an electrode array; An adaptive optimization module is used to monitor the electrophysiological response changes of the tissue during treatment, evaluate the strength of the ion-electromagnetic synergistic effect, and adjust the subsequent synergistic treatment strategy according to the treatment result feedback.

2. The multi-modal physiotherapy system integrating iontophoresis and electromagnetic stimulation of claim 1, wherein, The multi-parameter coupling analysis comprises: A coupling model of skin impedance, microcirculation blood flow and tissue temperature parameters is established, and when the skin impedance change rate exceeds the preset threshold and the tissue temperature is lower than the safety upper limit, the time stamp is recorded as the starting point of the ion permeation window period; The electromagnetic field intensity parameter is adjusted according to the comprehensive evaluation results of the tissue temperature parameter and the blood flow parameter, and when the temperature parameter exceeds the upper limit value, the electromagnetic field intensity is multiplied by a first preset coefficient, and when the blood flow parameter is lower than the preset threshold at the same time, the electromagnetic field intensity is multiplied by a second preset coefficient; The skin impedance change rate and the blood flow parameter growth rate are comprehensively analyzed, and when both satisfy the preset conditions, the tissue metabolic active state is determined and the synergistic treatment parameters are output.

3. The multi-modal physiotherapy system of claim 1, wherein, The generation of the synergistic treatment strategy comprises: combination analysis of the tissue metabolic active state, the temperature safety state and the impedance change state, setting corresponding treatment parameter levels for different state combinations, each level containing specific ion release concentration multiple, electromagnetic field intensity coefficient and action time proportion, forming a multi-level synergistic treatment strategy.

4. The multi-modal physiotherapy system of claim 1, wherein, The synchronization control of the timing of ion release and the timing of electromagnetic field excitation comprises: A low-frequency electromagnetic field pretreatment stage before ion release, a medium-frequency pulse electromagnetic field synchronization stage during ion release, and a high-frequency electromagnetic field maintenance stage after ion release; A three-stage timing control protocol, and the time interval between stages is dynamically adjusted according to the skin impedance change rate; A timing controller receives the time adjustment parameters in the synergistic treatment strategy, and generates a timing instruction table containing the starting time and duration of each stage.

5. The multi-modal physiotherapy system of claim 1, wherein, The space positioning technology comprises: Obtaining three-dimensional coordinate data of the skin surface, and establishing a spatial coordinate system of the treatment area; Calculating the geometric center coordinates and boundary coordinates of the ion release area; Detecting the current position coordinates of the electromagnetic field electrode, and calculating the geometric center coordinates of the electromagnetic field action area; Comparing the spatial deviation of the ion release area center coordinates and the electromagnetic field action area center coordinates, and generating a position adjustment instruction when the deviation exceeds the preset threshold; According to the position adjustment instruction, the electrode position parameter is corrected, and the spatial coincidence coefficient is recalculated.

6. The multi-modal physiotherapy system of claim 1, wherein, The multi-channel ion release module is configured to perform the following steps: The ion release control instruction is parsed to obtain ion type identification, release concentration parameter and release time parameter; According to the ion type identification, the corresponding ion storage channel is selected, and the volume flow rate of the ion solution in each channel is calculated; The opening angle and opening time of the microfluidic valve are set, and the opening and closing state of each channel is controlled according to the time sequence of the release time parameter; The flow sensor data of each channel is monitored, and when the deviation between the actual flow rate and the set flow rate exceeds the allowed range, the opening angle of the valve is adjusted; The cumulative release amount of each channel is recorded, and when the cumulative amount reaches the preset threshold, the ion release of the corresponding channel is stopped.

7. The multi-modal physiotherapy system of claim 1, wherein, The multi-frequency electromagnetic generation module is configured to perform the following steps: The electromagnetic field excitation control instruction is parsed to obtain frequency band selection parameter, field strength amplitude parameter and waveform type parameter; According to the frequency band selection parameter, the base frequency and modulation mode of the signal generator are determined, and the driving signal of the corresponding frequency band is generated; According to the field strength amplitude parameter, the gain coefficient of the power amplifier is adjusted, and electromagnetic field excitation signals of different intensities are outputted; According to the spatial coordinate parameter, the phase difference and amplitude ratio of each electrode are calculated, and the excitation parameter table of the electrode array is generated; The corresponding excitation signals are sequentially loaded to each electrode in the electrode array to form a spatially distributed controllable electromagnetic field.

8. The multi-modal physiotherapy system of claim 1, wherein, The evaluation of the strength of the ion-electromagnetic synergistic effect includes: The product of the ion release amount and the electromagnetic field intensity is calculated as the synergistic effect strength index; The change amplitude of the electrophysiological parameter before and after treatment is measured, and the quantitative relationship between the synergistic effect strength index and the improvement degree of electrophysiology is established; The difference between the current patient's electrophysiological improvement degree and the standard improvement degree is compared, and the individual response deviation coefficient is calculated; The effect evaluation result including the synergistic effect strength and the individual response deviation coefficient is outputted.

9. The multi-modal physiotherapy system of claim 1, wherein, The adjustment of the subsequent synergistic treatment strategy according to the treatment result feedback includes: According to the individual response deviation coefficient, the treatment parameters are proportionally corrected; When the individual response deviation coefficient is positive, the treatment intensity parameter of the next cycle is reduced by a proportional factor; When the individual response deviation coefficient is negative, the treatment intensity parameter of the next cycle is increased by a proportional factor; The adjustment range of the ion concentration parameter and the electromagnetic field parameter is dynamically corrected according to the response characteristics of different individuals.

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