Bacteriostatic sanitary wet tissue and preparation method thereof

Abstract

The invention relates to the technical field of wet tissues, in particular to an antibacterial sanitary wet tissue and a preparation method thereof. The antibacterial sanitary wet tissue comprises a fiber substrate and antibacterial liquid. The wet tissue is free of alcohol and quaternary ammonium salt, safe to use and suitable for nursing people with sensitive skin and infants. Glycerin, butanediol, panthenol, allantoin and sodium hyaluronate have a synergistic effect, and moisturizing and skin barrier repairing are provided. The wet tissue is prepared by adopting a conventional spraying process and a low-temperature condition and can be directly applied to an existing wet tissue production line without additional equipment. The product still keeps the antibacterial effect under high-temperature and high-humidity storage conditions, and is suitable for commercial circulation and long-term storage.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of wet wipes, in particular to a bacteriostatic sanitary wet wipe and a preparation method thereof. BACKGROUND

[0002] With the improvement of people's living standards and the enhancement of health consciousness, wet wipe products have been widely used in personal care, household cleaning, medical and health care and other fields. Traditional sanitary wet wipes mainly achieve bacteriostatic function by adding alcohol, quaternary ammonium salt or organic acid and other chemical preservatives, but such ingredients generally have the following problems: Firstly, alcohol-based wet wipes have strong irritation. Low molecular alcohols such as ethanol and isopropyl alcohol have good instantaneous bactericidal effect, but at the same time they can also damage the lipid barrier of the stratum corneum, causing dryness, stinging, allergy and other adverse reactions. Especially when used on infants, sensitive skin or damaged skin, the safety is poor.

[0003] Secondly, quaternary ammonium salt bacteriostatic agents have biological safety hazards. Cationic surfactants such as benzalkonium chloride, chlorhexidine and cetyltrimethylammonium bromide can form a residual film layer on the skin, which may cause cytotoxicity or microecological imbalance, and is easy to cause persistent pollution to the environment.

[0004] Thirdly, the stability of chemical bacteriostatic agents is limited. Most small molecule preservatives are easy to decompose, oxidize or volatilize in high temperature, high humidity or strong light environment, resulting in the attenuation of the bacteriostatic effect of wet wipe products during storage and the limitation of shelf life.

[0005] On the other hand, with the rise of green and sustainable consumption concept, consumers have higher requirements for wet wipe products: They not only hope that the products have natural bacteriostatic properties with mildness and low irritation, but also require them to have persistent and stable antibacterial activity and good skin feel experience. Therefore, how to significantly improve the bacteriostatic performance and stability while ensuring safety has become a technical problem that the industry urgently needs to solve.

[0006] In recent years, polyphenolic compounds (such as tannic acid, ellagic acid, chlorogenic acid and rhubarb polyphenol) in natural plant extracts have gradually attracted attention due to their natural source, antioxidant and antibacterial properties. Polyphenolic compounds can inhibit the growth of various pathogenic bacteria by destroying bacterial cell membranes, inhibiting enzyme activity and chelating metal ions. However, polyphenolic compounds themselves have the disadvantages of easy oxidation, photosensitivity, poor solubility and difficulty in maintaining activity in aqueous systems, which limits their application in daily chemical products such as wet wipes.

[0007] Meanwhile, Metal-Organic Frameworks (MOF) as a kind of porous crystal structure formed by self-assembly of metal ions and organic ligands, has high specific surface area, structural designability and good loading capacity. Studies have shown that certain MOF materials (such as ZIF-8, Cu-MOF, Bi-MOF, etc.) can release metal ions and produce synergistic antibacterial effect, and show good prospects in antibacterial dressings, air purification and biomedical materials. However, the water stability of traditional MOF materials is poor, and the structure collapses or the metal ions are released quickly in a humid environment, making it difficult to maintain long-term antibacterial performance.

[0008] Therefore, how to effectively combine natural polyphenols with MOF materials, both utilizing the biological activity of polyphenols and the structural stability and slow-release performance of MOF, is one of the current technical research hotspots. Some studies have tried to use the strategy of "polyphenol-metal complexation" or "polyphenol surface modification of MOF" to improve the stability and biocompatibility of the material, but it has not been maturely applied in daily wet wipe formula system, mainly limited by poor dispersibility, unstable pH system and insufficient compatibility with moisturizing ingredients, etc.

[0009] In addition, the existing wet wipes mostly use a single moisturizing system (such as glycerol or propylene glycol), which lacks skin barrier repair function. Long-term use may still cause slight dryness or tightness, which is not conducive to the balance of skin microecology.

[0010] In summary, there is still a lack of an antibacterial sanitary wet wipe with natural ingredient safety, MOF structural stability and long-acting antibacterial activity in the prior art. There is an urgent need for a new formula system that can achieve efficient, long-lasting and mild antibacterial care function at room temperature without using high-concentration alcohol or strong irritating preservatives, and has excellent skin affinity and storage stability. SUMMARY

[0011] The purpose of the present application is to provide an antibacterial sanitary wet wipe with long-acting antibacterial performance and mild safety to overcome the problems of skin irritation, unstable antibacterial performance and short storage period caused by the use of chemical preservatives in the prior art.

[0012] The present application forms a Metal-Organic Framework (MOF) material by combining polyphenol natural active substances (such as ellagic acid, tannic acid, and rhubarb polyphenol) with metal ions, and scientifically compounding moisturizing, repairing and preservative systems, so that the obtained wet wipe can still maintain high and long-lasting antibacterial effect under room temperature storage conditions, and has good skin compatibility.

[0013] The present application is realized by the following technical solutions: The bacteriostatic sanitary wet wipe comprises a fiber base and a bacteriostatic liquid; the fiber base is a spunlace non-woven fabric; the bacteriostatic liquid comprises the following components: a metal organic framework bacteriostatic material, deionized water, glycerol butanediol, ethylhexyl glycerin, panthenol, PEG-40 hydrogenated castor oil, citric acid, sodium citrate, allantoin, sodium hyaluronate and 0.6 phenoxyethanol; the metal organic framework bacteriostatic material is at least one selected from the group consisting of a hydrothermal tannic acid bismuth MOF, a tannic acid bismuth MOF, a tannic acid modified ZIF-8, a rhubarb polyphenol modified ZIF-8 and a water extracted rhubarb polyphenol modified ZIF-8.

[0014] Further, the bacteriostatic liquid comprises, by weight: 2 parts of the metal organic framework bacteriostatic material, 85.5 parts of deionized water, 2 parts of glycerol, 3 parts of butanediol, 0.5 parts of ethylhexyl glycerin, 0.3 parts of panthenol, 0.3 parts of PEG-40 hydrogenated castor oil, 0.15 parts of citric acid, 0.25 parts of sodium citrate, 0.3 parts of allantoin, 0.1 parts of sodium hyaluronate, 0.6 parts of phenoxyethanol.

[0015] Further, the pH of the bacteriostatic liquid is 5.5-6.0.

[0016] Further, the metal organic framework bacteriostatic material is a hydrothermal tannic acid bismuth MOF.

[0017] Further, the preparation method of the hydrothermal tannic acid bismuth MOF is as follows: 10 mg of tannic acid and 24 mg of bismuth acetate are added to 3 mL of deionized water, then transferred to a high-pressure reaction kettle, then heated to 120°C for 16 hours, then centrifuged at 8000 rpm for 10 minutes, and then placed in a 60°C oven overnight; after washing with water and ethanol, drying.

[0018] Further, the metal organic framework bacteriostatic material is a tannic acid bismuth MOF.

[0019] Further, the preparation method of the tannic acid bismuth MOF is as follows: 3.3 g of tannic acid and 7.6 g of bismuth acetate are added to a beaker containing a mixture of 600 mL of water and acetic acid; the solution is stirred for 48 hours, then centrifuged and dried.

[0020] Further, the wet wipe has an initial bacteriostatic rate of ≥99% on Staphylococcus aureus, and after being stored at 30°C and a relative humidity of 75% for 180 days, the bacteriostatic rate on Staphylococcus aureus is maintained at ≥92%.

[0021] The application also provides a preparation method of the bacteriostatic sanitary wet wipe, comprising the following steps: spraying the bacteriostatic liquid with a temperature of 40°C onto the spunlace non-woven fabric, a total of 1 time; the spraying amount in the spraying is 150 g / m 2.

[0022] Compared with the prior art, the present application has the following advantages and beneficial effects: The MOF material is formed by compounding with natural polyphenolic compounds. The porous structure of MOF and the antibacterial properties of metal ions are used to achieve slow release and stable protection of active substances. The hydroxyl groups in natural polyphenols are coordinated with the MOF skeleton metal to improve the stability and antioxidant properties of the system. The pH is maintained at 5.5-6.0 by a citric acid / sodium citrate buffer system to keep the polyphenols and bioactive components stable. Glycerol, butanediol, and sodium hyaluronate form a triple moisturizing system to improve skin feel and moisture. PEG-40 hydrogenated castor oil is used to help dissolve the MOF dispersion to prevent settling or clumping. Phenoxyethanol and ethylhexylglycerin are used in combination to provide broad-spectrum antibacterial properties. In combination with the MOF bacteriostatic agent, the traditional alcohol or quaternary ammonium salt irritation is avoided. The bacteriostatic liquid is heated to 40℃ and uniformly applied to the spunlace non-woven fabric in a spraying manner, with a spraying amount of 150g / m². After standing and adsorbing, the product is sealed and packaged. The obtained wet wipes have an initial antibacterial rate of ≥99% against Staphylococcus aureus, and still maintain an antibacterial rate of ≥97% after 180 days of storage, showing significant long-term antibacterial stability. The wet wipes in the present application are alcohol-free and quaternary ammonium salt-free, safe to use, and suitable for skin-sensitive people and infant care. Glycerol, butanediol, panthenol, allantoin, and sodium hyaluronate work together to provide moisturizing and skin barrier repair effects. The product is prepared using conventional spraying process and low temperature conditions, and can be directly applied to the existing wet wipe production line without additional equipment. The product still maintains antibacterial effect under high temperature and high humidity storage conditions, suitable for commercial circulation and long-term preservation. DETAILED DESCRIPTION

[0023] In order to make the purpose, technical scheme and advantages of the present application clearer, further detailed description will be given below in combination with examples, and the illustrative embodiments of the present application and their descriptions are only used to explain the present application, but not as a limitation of the present application.

[0024] Example 1 A bacteriostatic sanitary wet wipe, comprising a fiber base and a bacteriostatic liquid.

[0025] The fiber base is a spunlace non-woven fabric; The bacteriostatic liquid comprises: 2 parts of water heat method bismuth tannic acid MOF, 85.5 parts of deionized water, 2 parts of glycerol, 3 parts of butanediol, 0.5 parts of ethylhexylglycerin, 0.3 parts of panthenol, 0.3 parts of PEG-40 hydrogenated castor oil, 0.15 parts of citric acid, 0.25 parts of sodium citrate, 0.3 parts of allantoin, 0.1 parts of sodium hyaluronate, and 0.6 parts of phenoxyethanol. The pH value of the bacteriostatic liquid is controlled at 5.5-6.0.

[0026] The preparation method of the bacteriostatic sanitary wet wipe is: The bacteriostatic solution at a temperature of 40°C is sprayed onto the spunlace nonwoven fabric, a total of 1 time, and the spraying amount is 150 g / m 2 .

[0027] The preparation method of the tannic acid bismuth MOF in this example is: 10 mg of tannic acid and 24 mg of bismuth acetate are added to 3 mL of deionized water, then transferred to a high-pressure reaction kettle, then heated to 120°C for 16 hours, then centrifuged at 8000 rpm for 10 minutes, and then placed in a 60°C oven overnight; after washing with water and ethanol, dried at 60°C overnight.

[0028] Example 2 A bacteriostatic sanitary wet wipe, comprising a fiber base and a bacteriostatic solution.

[0029] The fiber base is a spunlace nonwoven fabric; The bacteriostatic solution comprises: 2 parts of tannic acid bismuth MOF, 85.5 parts of deionized water, 2 parts of glycerol, 3 parts of butanediol, 0.5 parts of ethylhexyl glycerin, 0.3 parts of panthenol, 0.3 parts of PEG-40 hydrogenated castor oil, 0.15 parts of citric acid, 0.25 parts of sodium citrate, 0.3 parts of allantoin, 0.1 parts of sodium hyaluronate, and 0.6 parts of phenoxyethanol. The pH value of the bacteriostatic solution is controlled at 5.5-6.0.

[0030] The preparation method of the bacteriostatic sanitary wet wipe is: The bacteriostatic solution at a temperature of 40°C is sprayed onto the spunlace nonwoven fabric, a total of 1 time, and the spraying amount is 150 g / m 2 .

[0031] The preparation method of the tannic acid bismuth MOF in this example is: 3.3 g of tannic acid and 7.6 g of bismuth acetate are added to a beaker containing 600 mL of a mixture of water and acetic acid (6 vol.% acetic acid); the solution is stirred for 48 hours, then centrifuged at 8000 rpm for 10 minutes, and then placed in a 60°C oven overnight; after washing with water and ethanol, dried at 60°C overnight.

[0032] Example 3 A bacteriostatic sanitary wet wipe, comprising a fiber base and a bacteriostatic solution.

[0033] The fiber base is a spunlace nonwoven fabric; The bacteriostatic solution comprises 2 parts of tannic acid modified ZIF-8, 85.5 parts of deionized water, 2 parts of glycerol, 3 parts of butanediol, 0.5 parts of ethylhexylglycerin, 0.3 parts of panthenol, 0.3 parts of PEG-40 hydrogenated castor oil, 0.15 parts of citric acid, 0.25 parts of sodium citrate, 0.3 parts of allantoin, 0.1 parts of sodium hyaluronate, and 0.6 parts of phenoxyethanol. The pH value of the bacteriostatic solution is controlled at 5.5-6.0.

[0034] The preparation method of the bacteriostatic sanitary wet wipe is as follows: The bacteriostatic solution at a temperature of 40°C is sprayed onto the spunlace non-woven fabric for a total of 1 time, and the spraying amount is 150 g / m 2 .

[0035] The preparation method of the tannic acid modified ZIF-8 in this embodiment is as follows: , 2-methylimidazole (6.5 g) is mixed with ethanol (200.0 mL) and left to stand at room temperature for 30 min; an ethanol solution (20.0 mL) containing tannic acid (0.5 g) is added, and the system is left to stand at room temperature for another 30 min; after the system is left to stand at room temperature for 24 h, the solid is collected by centrifugation at 6000 rpm for 15 min, washed with ethanol for three times, and vacuum dried at 60°C overnight to obtain the tannic acid modified ZIF-8.

[0036] Example 4 A bacteriostatic sanitary wet wipe, comprising a fiber substrate and a bacteriostatic solution.

[0037] The fiber substrate is a spunlace non-woven fabric; The bacteriostatic solution comprises 2 parts of tannic acid modified ZIF-8, 85.5 parts of deionized water, 2 parts of glycerol, 3 parts of butanediol, 0.5 parts of ethylhexylglycerin, 0.3 parts of panthenol, 0.3 parts of PEG-40 hydrogenated castor oil, 0.15 parts of citric acid, 0.25 parts of sodium citrate, 0.3 parts of allantoin, 0.1 parts of sodium hyaluronate, and 0.6 parts of phenoxyethanol. The pH value of the bacteriostatic solution is controlled at 5.5-6.0.

[0038] The preparation method of the bacteriostatic sanitary wet wipe is as follows: The bacteriostatic solution at a temperature of 40°C is sprayed onto the spunlace non-woven fabric for a total of 1 time, and the spraying amount is 150 g / m 2 .

[0039] The preparation method of the tannic acid modified ZIF-8 in this embodiment is as follows: Rhubarb polyphenols modified ZIF-8 was prepared by mixing 2-methylimidazole (6.5 g) with ethanol (200.0 mL) at room temperature for 30 min, adding an ethanol solution (20.0 mL) containing water-extracted rhubarb polyphenols (0.5 g), and continuing to stand at room temperature for 30 min; after the system was allowed to stand at room temperature for 24 h, the solid was collected by centrifugation at 6000 rpm for 15 min, washed with ethanol three times, and dried in a vacuum at 60°C overnight to obtain rhubarb polyphenols modified ZIF-8; The extraction method of rhubarb polyphenols is as follows: 0.2 g of dry powder of the roots and rhizomes of rhubarb is mixed with 18 mL of 75% (v / v) ethanol water in a flask, and ultrasonic extraction is performed under the conditions of a power of 800 W and a working frequency of 45 kHz for 30 min; After the extraction is completed, the solution is filtered through a 0.45 μm filter membrane, 5 mL of the filtrate is subjected to plate evaporation, and then drying in a water bath. The residue after drying is dissolved with 10 mL of water, 1 mL of hydrochloric acid is added, heated to reflux for 30 min, and then extracted twice with 20 mL of diethyl ether; finally, the diethyl ether solutions obtained by the two extractions are combined, and vacuum drying is performed to obtain rhubarb polyphenols.

[0040] Example 5 A bacteriostatic sanitary wet wipe comprises a fibrous substrate and a bacteriostatic liquid.

[0041] The fibrous substrate is a spunlace non-woven fabric; The bacteriostatic liquid comprises: 2 parts of water-extracted rhubarb polyphenols modified ZIF-8, 85.5 parts of deionized water, 2 parts of glycerol, 3 parts of butanediol, 0.5 parts of ethylhexylglycerin, 0.3 parts of panthenol, 0.3 parts of PEG-40 hydrogenated castor oil, 0.15 parts of citric acid, 0.25 parts of sodium citrate, 0.3 parts of allantoin, 0.1 parts of sodium hyaluronate, and 0.6 parts of phenoxyethanol. The pH value of the bacteriostatic liquid is controlled at 5.5-6.0.

[0042] The preparation method of the bacteriostatic sanitary wet wipe is as follows: The bacteriostatic liquid at a temperature of 40°C is sprayed onto the spunlace non-woven fabric, a total of 1 time, and the spraying amount is 150 g / m 2 .

[0043] The preparation method of water-extracted rhubarb polyphenols modified ZIF-8 in this example is as follows: The , 2-methylimidazole (6.5 g) is mixed with ethanol (200.0 mL) at room temperature for 30 min, an ethanol solution (20.0 mL) containing water-extracted rhubarb polyphenols (0.5 g) is added, and the system is allowed to stand at room temperature for 30 min; after the system is allowed to stand at room temperature for 24 h, the solid is collected by centrifugation at 6000 rpm for 15 min, washed with ethanol three times, and dried in a vacuum at 60°C overnight to obtain rhubarb polyphenols modified ZIF-8; The extraction method of the water-extracted rhubarb polyphenol is as follows: 10 g of dried powder of rhubarb roots and rhizomes is weighed, 100 mL of water is used to decoct the powder for three times at 100 ℃, each time for 1 hour; the decocted liquid obtained is filtered, and dried at 60 ℃ under reduced pressure to obtain the water-extracted rhubarb polyphenol.

[0044] Test Example 1 The antibacterial health wet wipes of Examples 1-5 of the present application were subjected to performance testing. Among them, the antibacterial performance was determined according to the national standard GB / T 15979-2002, the above packaged wet wipe material was stored at a temperature of 30 ℃ and a relative humidity of 75% for 180 days, and then the stability was evaluated by determining the antibacterial performance. The results are shown in Table 1.

[0045] Table 1 Performance test

[0046] The above-described specific embodiments further illustrate the purposes, technical solutions and beneficial effects of the present application, and it should be understood that the above-described embodiments are merely specific embodiments of the present application and are not intended to limit the protection scope of the present application. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present application shall be included in the protection scope of the present application.

Claims

1. An antibacterial sanitary wipe, characterized in that, The antibacterial sanitary wipes include a fiber base and an antibacterial liquid; The fiber substrate is a spunlace nonwoven fabric; The antibacterial solution comprises the following components: metal-organic framework antibacterial material, deionized water, glyceryl butanediol, ethylhexylglycerin, panthenol, PEG-40 hydrogenated castor oil, citric acid, sodium citrate, allantoin, sodium hyaluronate, and phenoxyethanol. The metal-organic framework antibacterial material is selected from at least one of hydrothermal bismuth ellagicate MOF, bismuth ellagicate MOF, tannic acid modified ZIF-8, rhubarb polyphenol modified ZIF-8, and water-extracted rhubarb polyphenol modified ZIF-8.

2. The antibacterial sanitary wipes as described in claim 1, characterized in that, The antibacterial solution comprises, by weight: 2 parts of metal-organic framework antibacterial material, 85.5 parts of deionized water, 2 parts of glycerin, 3 parts of butylene glycol, 0.5 parts of ethylhexylglycerin, 0.3 parts of panthenol, 0.3 parts of PEG-40 hydrogenated castor oil, 0.15 parts of citric acid, 0.25 parts of sodium citrate, 0.3 parts of allantoin, 0.1 parts of sodium hyaluronate, and 0.6 parts of phenoxyethanol.

3. The antibacterial sanitary wipes as described in claim 2, characterized in that, The pH of the antibacterial solution is 5.5–6.

0.

4. The antibacterial sanitary wipes as described in claim 3, characterized in that, The metal-organic framework antibacterial material is selected from hydrothermal bismuth ellagicate (MOF).

5. The antibacterial sanitary wipes as described in claim 4, characterized in that, The hydrothermal method for preparing bismuth ellagicate MOF is as follows: 10 mg of ellagic acid and 24 mg of bismuth acetate are added to 3 mL of deionized water, then transferred to a high-pressure reactor, heated to 120°C and maintained for 16 hours, then centrifuged at 8000 rpm for 10 minutes, and then placed in a 60°C oven overnight; after washing with water and ethanol, it is dried.

6. The antibacterial sanitary wipes as described in claim 3, characterized in that, The metal-organic framework antibacterial material is selected from bismuth ellagicate (MOF).

7. The antibacterial sanitary wipes as described in claim 6, characterized in that, The preparation method of the bismuth ellagicate MOF is as follows: Add 3.3 g ellagic acid and 7.6 g bismuth acetate to a mixture containing 600 mL of water and acetic acid; stir the solution for 48 hours, then centrifuge and dry.

8. The antibacterial sanitary wipes as described in any one of claims 1 to 7, characterized in that, The wipes initially showed an inhibition rate of ≥99% against Staphylococcus aureus, and after being stored at 30°C and 75% relative humidity for 180 days, the inhibition rate against Staphylococcus aureus remained at ≥92%.

9. The method for preparing antibacterial sanitary wipes according to any one of claims 1 to 7, characterized in that, The process includes the following steps: spraying an antibacterial solution at a temperature of 40°C onto the spunlace nonwoven fabric, repeating the spraying process once.

10. The preparation method according to claim 9, characterized in that, The spraying rate is 150g / m³ 2 .

Images