Anti-aging and skin-tendering composition and preparation method thereof

Abstract

The invention discloses an anti-aging and skin-tendering composition and a preparation method thereof. The anti-aging and skin-tendering composition comprises glycerin, dipropylene glycol, trehalose, a cynomorium songaricum extract, acetyl tetrapeptide-11, palmitoyl tripeptide-38, sodium hyaluronate, caprylic / capric triglyceride, isononyl isononanoate, phytosterol, meadowfoam seed oil, an emulsifier, a thickening stabilizer, superoxide dismutase, fullerene, ergothioneine, an osmotic regulator and a pH regulator. A preservative and deionized water. An existing formula system is completely abandoned, brand-new core functional components are introduced, the design of constructing a complete channel of telomere protection, signal activation, oxidation resistance, barrier repair and energy supplement to cooperate with aging resistance is adopted, the multiple aging resisting, repairing and skin tendering effects are achieved, and the skin tendering effect is achieved. The excellent effects of resisting wrinkles, lifting, moisturizing and improving the skin quality are realized, and the product is stable and safe.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of cosmetic technology, in particular to an anti-aging and skin-nourishing composition with multiple anti-aging, repairing and skin-nourishing effects and a preparation method thereof. BACKGROUND

[0002] Skin aging is a complex physiological process, mainly manifested as wrinkle formation, skin laxity, loss of elasticity, dryness and roughness, and pigmentation, etc. Its internal mechanisms include telomere shortening, cell aging, genomic instability, epigenetic changes, loss of protein homeostasis, nutrient sensing disorder, mitochondrial dysfunction and changes in cell-cell communication, etc. External factors such as ultraviolet radiation (photoaging), pollution, and unhealthy lifestyle habits can accelerate this process.

[0003] Currently, anti-aging skin care products on the market mostly focus on a single pathway, such as collagen supplementation, strong antioxidant or simple moisturizing. For example, Chinese patent application CN117159438A discloses an anti-aging and skin-nourishing compound, which has complex ingredients including bifida yeast fermentation product, various ceramides, hydroxypropyl tetrahydropyran triol and other common functional ingredients. However, such formulations have the following shortcomings: (1) the components are too complex, the synergistic effect between components is not clear, and the skin may be sensitized; (2) insufficient attention is paid to deep anti-aging mechanisms such as cell energy metabolism and telomere protection; (3) ceramides and other components are costly, and the skin compatibility of chemically synthesized ceramides needs to be further improved.

[0004] Therefore, there is an urgent need in the art to develop an anti-aging and skin-nourishing composition with scientific formula design, clear mechanism, targeting multiple levels of aging pathways, and excellent stability and safety. SUMMARY

[0005] The present application aims to overcome the shortcomings of the prior art and provide an anti-aging and skin-nourishing composition with novel formula, synergistic effect, and good stability, and a preparation method thereof. By constructing a complete pathway of "telomere protection-signal activation-antioxidation-barrier repair-energy supplementation" for synergistic anti-aging, it has multiple anti-aging, repairing and skin-nourishing effects, achieving excellent anti-wrinkle, lifting, moisturizing and skin quality improvement effects, and the product is stable and safe.

[0006] To achieve the above-mentioned purposes, the present application adopts the following technical solutions:

[0007] In a first aspect, the present application provides an anti-aging skin care composition comprising, by weight percentage, the following components: glycerin 3.0-8.0%, dipropylene glycol 2.0-5.0%, trehalose 1.0-3.0%, horny goat weed extract 0.5-2.0%, acetyl tetrapeptide-11 0.05-0.2%, palmitoyl tripeptide-38 0.05-0.2%, sodium hyaluronate 0.05-0.3%, caprylic / capric triglyceride 3.0-10.0%, isononyl isononanoate 1.0-5.0%, phytosterol 0.1-0.5%, white pool rapeseed oil 0.5-2.0%, emulsifier 2.4-6%, thickening stabilizer 0.5-2.0%, superoxide dismutase 0.01-0.1%, fullerene 0.1-0.5%, ergothioneine 0.05-0.2%, osmotic regulator 0.5-2.0%, pH regulator 0.1-0.3%, preservative 0.45-1.2%, and deionized water in the remainder.

[0008] In some specific embodiments, the anti-aging skin care composition comprises, by weight percentage, the following components: glycerin 5%, dipropylene glycol 3%, trehalose 2%, horny goat weed extract 1%, acetyl tetrapeptide-11 0.1%, palmitoyl tripeptide-38 0.1%, sodium hyaluronate 0.1%, caprylic / capric triglyceride 6%, isononyl isononanoate 3%, phytosterol 0.2%, white pool rapeseed oil 1%, emulsifier 4%, thickening stabilizer 1%, superoxide dismutase 0.05%, fullerene 0.3%, ergothioneine 0.1%, osmotic regulator 1%, pH regulator 0.2%, preservative 0.75%, and deionized water in the remainder.

[0009] In some specific embodiments, the fullerene is water-soluble fullerene. The water-soluble fullerene, by the dispersion effect of water-soluble polymer PVP, forms a water-soluble cosmetic raw material, which can absorb free radicals in the human body, not only helps to repair cell damage, but also stimulates cell regeneration and speeds up cell metabolism, thereby effectively resisting skin aging.

[0010] In some specific embodiments, the emulsifier is composed of cetearyl olivate / sorbitan olivate, cetearyl olivate with a mass ratio of 3:1.

[0011] In some specific embodiments, the thickening stabilizer is acryloyldimethyltaurine sodium / VP copolymer.

[0012] In some specific embodiments, the osmotic regulator is trimethylglycine.

[0013] In some specific embodiments, the pH regulator is at least one of citric acid, sodium benzoate, and potassium sorbate.

[0014] In some specific technical solutions, the preservative is composed of 1,2-hexanediol and octanediol with a mass ratio of 2:1.

[0015] The overall design concept of the formula is that the application adopts a multi-level and multi-target anti-aging design, constructs a complete anti-aging network from the cell level to the epidermis level by selecting core components of each pathway, and avoids simple piling of components to achieve synergistic effect.

[0016] Specifically, the specific effects and effects of each component are described as follows:

[0017] (1) Deep protection and activation component

[0018] Cynomys root extract: rich in cynomys polysaccharide, can be used as a plant telomere protective agent, simulates the effect of caloric restriction, activates Sirtuins longevity protein (such as SIRT1 and SIRT6), and improves telomerase activity, thereby inhibiting the shortening of telomeres as a cell "biological clock" and protecting the length of telomeres, directly delaying the process of replicative senescence of cells. It can also enhance the resistance of cells to stress, and improve skin vitality from the root.

[0019] (2) Signal regulation and repair component

[0020] Acetyl tetrapeptide-11: as a signal peptide, it can simulate collagen fragments to send repair signals to skin fibroblasts, promote the synthesis of type I and III collagen, effectively reduce the depth and number of wrinkles, and improve skin tightness.

[0021] Palmitoyl tripeptide-38: synergistic effect with acetyl tetrapeptide-11, this peptide can specifically promote the synthesis of type IV collagen and laminin, strengthen the structure of the basement membrane, and improve skin elasticity and tightness. The combination of the two can produce a superimposed effect.

[0022] (3) Strong antioxidant network component

[0023] Superoxide dismutase (SOD): as the primary antioxidant enzyme, it can efficiently catalyze the conversion of superoxide anion free radicals to hydrogen peroxide and oxygen, directly removing the primary product of oxidative stress and reducing cell damage.

[0024] Fullerene: a strong antioxidant with a unique cage structure, it can continuously adsorb and neutralize various free radicals (such as hydroxyl radicals and superoxide anions) like a "free radical sponge", providing long-term and stable antioxidant protection, which is much more effective than traditional antioxidants.

[0025] Tocopherol: A natural antioxidant that can penetrate cell membranes and protect cells from oxidative damage, helping to maintain mitochondrial function and reduce DNA damage.

[0026] (4) Barrier Repair and Moisturizing Components

[0027] Glycerin: As a classic moisturizer, it captures moisture from the environment through hygroscopicity, maintains water content in the stratum corneum, keeps the skin moist, improves dry and rough skin, and repairs the skin barrier function.

[0028] Dipropylene glycol: As a moisturizer and solvent, it has both moisturizing and penetration-promoting effects, helping other active ingredients to be better absorbed by the skin, while providing a refreshing skin feel.

[0029] Trehalose: A natural small molecule sugar that acts as a natural moisturizer, can form a protective hydration film on the cell surface to prevent water loss, and can improve cell survival rate under stress such as dryness and ultraviolet light, with anti-stress effect.

[0030] Sodium Hyaluronate: As a highly effective moisturizer, sodium hyaluronate of different molecular weights can lock water in the skin surface and deep layers. Low molecular weight can penetrate into the dermis to promote repair, and high molecular weight can form a water-locking film in the epidermis. Through the synergistic effect of sodium hyaluronate of different molecular weights, it can achieve three-dimensional moisturizing, filling wrinkles, and improving skin texture.

[0031] Phytosterols: Similar in structure to cholesterol, they can mimic skin lipids, embed in the skin lipid bilayer, repair damaged skin barrier, reduce transdermal water loss, and have anti-inflammatory properties.

[0032] White pool seed oil: A very stable plant oil rich in long-chain fatty acids and antioxidant components, which can form a soft protective film on the skin surface, provide long-lasting nourishment, protect the skin from oxidative damage, and enhance the stability of other lipid-soluble active substances.

[0033] (5) Cell Energy Supplement Components

[0034] Trimethylglycine: It acts as a penetration regulator. As a penetration compensating solute, it can stabilize protein structure, provide energy to cells (as a methyl donor), improve cell vitality under osmotic stress, and enhance the hydration capacity of the skin.

[0035] (6) Basic and Auxiliary Components

[0036] Deionized water: As a solvent and carrier, it ensures uniform dispersion and stable existence of all components.

[0037] Caprylic / capric triglyceride: light synthetic oil, gives the product a good spreadability and a moisturizing feel without a greasy burden.

[0038] Isocetyl isononanoate: improves product texture, gives a smooth and easy to spread skin feel, enhances user experience.

[0039] Cetearyl olivate / sorbitan olivate: natural emulsifier system from olive oil, mild and efficient, forms stable O / W emulsion structures, while providing additional emollient benefits. Emulsifies while effectively repairing the skin barrier function, reducing external irritants, long-lasting moisturization.

[0040] Cetearyl olivate: as emulsifier and emollient, from olive oil, provides mild emulsification and skin softening benefits.

[0041] Acrylates / dimethylaminoethyl methacrylate / VP copolymer: as thickening and stabilizing agent, gives the product a suitable viscosity, enhances emulsion stability, prevents separation and sedimentation during storage.

[0042] Citric acid, 1,2-hexanediol, caprylyl glycol: mild pH adjustment and preservative system. Citric acid maintains the product pH in the physiological range of the skin (about 5.5-6.0), reduces irritation and enhances stability. 1,2-hexanediol and caprylyl glycol synergistically provide broad-spectrum antibacterial action, while also having moisturizing functions, replacing traditional irritating preservatives.

[0043] In a second aspect, the present application further provides a preparation method of the anti-aging skin care composition, comprising the following steps:

[0044] S1, mixing deionized water, glycerin, dipropylene glycol, trehalose, sodium hyaluronate, and osmotic regulator, heating to 75-78°C, homogenously stirring to obtain an aqueous phase component;

[0045] S2, mixing caprylic / capric triglyceride, isononyl isononanoate, emulsifier, phytosterol, and white pool seed oil, heating to 75-78°C to dissolve, to obtain an oil phase component;

[0046] S3, adding the oil phase component to the aqueous phase component under stirring, high-speed homogenizing emulsification;

[0047] S4, cooling to below 45°C, adding thickening and stabilizing agent, stirring uniformly;

[0048] S5, continuing to cool to below 40°C, sequentially adding horny goat weed extract, acetyl tetrapeptide-11, palmitoyl tripeptide-38, superoxide dismutase, fullerene, and ergothioneine, stirring uniformly;

[0049] S6, adding pH adjusting agent and preservative, stirring until completely uniform;

[0050] S7, cooling to 30 DEG C or below, discharging to obtain the anti-aging skin composition.

[0051] In some specific technical solutions, in step S3, the rotation speed of the high-speed homogenization emulsification is 4000 rpm-6000 rpm, and the time is 3 min-6 min.

[0052] Compared with the prior art, the anti-aging skin composition and the preparation method thereof have the following beneficial effects:

[0053] 1. The present application completely abandons the existing formula system, introduces a brand-new core efficacy component, and forms a multi-level, multi-target anti-aging design:

[0054] (1) Deep protection and activation: through the use of Cynomorium songaricum extract, the heat restriction effect is simulated, Sirtuins longevity protein is activated, and telomeres are protected, thereby delaying the aging process from the cellular level.

[0055] (2) Signal regulation and repair: a brand-new signal peptide combination is constructed by using acetyl tetrapeptide-11 and palmitoyl tripeptide-38 in cooperation, which simulates collagen fragments, sends repair signals to fibroblasts, promotes the synthesis of collagen types I, III and IV, and laminin, and effectively improves wrinkles and enhances skin tightness.

[0056] (3) Strong antioxidant network: a strong antioxidant network combination composed of superoxide dismutase, fullerene and ergothioneine is constructed. Superoxide dismutase removes superoxide anions first, fullerene acts as a "free radical sponge" to continuously remove various free radicals, and ergothioneine provides intracellular protection. The three work together to comprehensively resist oxidative stress damage.

[0057] (4) Barrier repair and moisturizing: phytosterols and white pool seed oil are used in cooperation to simulate skin lipids and repair the skin barrier. Trehalose and trimethylglycine form a natural moisturizing complex to form a protective film around cells, achieving long-acting moisturizing. Sodium hyaluronate locks and moisturizes water from different molecular levels.

[0058] (5) Cell energy supplement: trimethylglycine, as an osmotic regulator, can also provide energy for cells and improve cell vitality.

[0059] 2. Formulation is simple and efficient: The present application avoids simple stacking of ingredients, and realizes multi-dimensional anti-aging of "telomere protection-signal activation-antioxidation-barrier repair-energy supplement" through the selection of core ingredients in each pathway and the optimization of the ratio, with synergistic effect, reducing the potential irritation risk. For example, the cells protected by Cynomorium songaricum extract synthesize collagen more efficiently under the guidance of peptide signals; a strong antioxidant network creates a low oxidative stress environment for cell repair; barrier repair components ensure that active substances penetrate effectively and maintain the basis of skin health. This synergistic effect makes the anti-aging and skin-whitening composition of the present application significantly better than single ingredients or simply compounded products in terms of anti-wrinkle, lifting, moisturizing and improving skin quality.

[0060] 3. Stable and mild process: A milder low-temperature emulsification process is used, and heat-sensitive active substances are added at an appropriate temperature stage, which maximizes the biological activity of each component, especially peptides, enzymes and plant extracts.

[0061] 4. High safety: Mainly using ingredients of natural or biotechnological origin, mild and low irritation, suitable for a variety of skin types including sensitive skin.

[0062] The anti-aging and skin-whitening composition of the present application can be applied to skin care formulations and developed into corresponding efficient anti-aging cosmetics. DETAILED DESCRIPTION

[0063] The technical solutions of the present application will be described clearly and completely below. Obviously, the described embodiments are only a part of the embodiments of the present application, not all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0064] The present application will be further described in detail below through specific examples.

[0065] In the examples and comparative examples of the present application, the experimental methods used are conventional methods unless otherwise specified, and the raw materials, reagents, etc. used are commercially available unless otherwise specified. Those skilled in the art know that any equivalent product meeting the specifications of cosmetic raw materials can be used to realize the present application.

[0066] Example 1

[0067] The embodiment provides an anti-aging skin composition, and the formula composition is as follows (in percentage by weight): glycerin 5%, dipropylene glycol 3%, trehalose 2%, horny goat weed extract 1%, acetyl tetrapeptide-11 0.1%, palmitoyl tripeptide-38 0.1%, sodium hyaluronate 0.1%, caprylic / capric triglyceride 6%, isononyl isononanoate 3%, phytosterol 0.2%, white pool rapeseed oil 1%, emulsifier 4%, thickening stabilizer 1%, superoxide dismutase 0.05%, fullerene 0.3%, ergothioneine 0.1%, osmotic regulator 1%, pH regulator 0.2%, preservative 0.75% and deionized water in the remainder.

[0068] In the formula, the fullerene is water-soluble fullerene, the emulsifier is composed of cetearyl olivate / sorbitan olivate and cetearyl olivate with a mass ratio of 3:1, the thickening stabilizer is acryloyldimethyltaurine sodium / VP copolymer, the osmotic regulator is trimethylglycine, the pH regulator is citric acid, and the preservative is composed of 1,2-hexanediol and caprylyl glycol with a mass ratio of 2:1.

[0069] The preparation method of the anti-aging skin composition comprises the following steps.

[0070] S1, deionized water, glycerin, dipropylene glycol, trehalose, sodium hyaluronate and an osmotic regulator are added to a main kettle, stirred and heated to 76 DEG C, and then homogenized and uniformly stirred to obtain a water phase component;

[0071] S2, caprylic / capric triglyceride, isononyl isononanoate, an emulsifier, phytosterol and white pool rapeseed oil are added to an oil phase kettle, stirred and heated to 78 DEG C to completely dissolve, and then an oil phase component is obtained;

[0072] S3, the oil phase component is slowly added to the water phase component under stirring, and then high-speed homogenization emulsification is performed at 5000 rpm for 5 min;

[0073] S4, slow cooling is performed to 45 DEG C, a thickening stabilizer is added, and then stirred and uniformly mixed;

[0074] S5, continuous cooling is performed to below 40 DEG C, and then horny goat weed extract, acetyl tetrapeptide-11, palmitoyl tripeptide-38, superoxide dismutase, fullerene and ergothioneine are sequentially added, and then stirred and uniformly mixed after each addition of raw material;

[0075] S6, finally, a pH regulator and a preservative are added, and then stirred until completely uniform;

[0076] S7, cooling is performed to below 30 DEG C, and then the anti-aging skin composition is discharged.

[0077] Embodiment 2

[0078] The embodiment provides an anti-aging skin composition, wherein the use amount of each component is adjusted, and the rest is unchanged. Specifically, the formula of the anti-aging skin composition is as follows (in percentage by weight): glycerin 4%, dipropylene glycol 2.5%, trehalose 1.5%, horny goat weed extract 0.8%, acetyl tetrapeptide-11 0.08%, palmitoyl tripeptide-38 0.08%, sodium hyaluronate 0.08%, caprylic / capric triglyceride 5%, isononyl isononanoate 2%, phytosterol 0.15%, white pool seed oil 0.8%, emulsifier 3.2%, thickening stabilizer 0.8%, superoxide dismutase 0.03%, fullerene 0.2%, ergothioneine 0.08%, penetration regulator 0.8%, pH regulator 0.15%, preservative 0.6%, and deionized water in the remainder.

[0079] The preparation method of the anti-aging skin composition of the embodiment is the same as that of the embodiment 1, and does not need to be repeated here.

[0080] Embodiment 3

[0081] The embodiment provides an anti-aging skin composition, wherein the use amount of each component is adjusted, and the rest is unchanged. Specifically, the formula of the anti-aging skin composition is as follows (in percentage by weight): glycerin 4%, dipropylene glycol 2.5%, trehalose 1.5%, horny goat weed extract 0.8%, acetyl tetrapeptide-11 0.08%, palmitoyl tripeptide-38 0.08%, sodium hyaluronate 0.08%, caprylic / capric triglyceride 5%, isononyl isononanoate 2%, phytosterol 0.15%, white pool seed oil 0.8%, emulsifier 3.2%, thickening stabilizer 0.8%, superoxide dismutase 0.03%, fullerene 0.2%, ergothioneine 0.08%, penetration regulator 0.8%, pH regulator 0.15%, preservative 0.6%, and deionized water in the remainder.

[0082] The preparation method of the anti-aging skin composition of the embodiment is the same as that of the embodiment 1, and does not need to be repeated here.

[0083] Embodiment 4

[0084] The present example provides an anti-aging skin composition, which is different from example 1 in that the amount of each component is adjusted, and the rest remains unchanged. Specifically, the formula of the anti-aging skin composition is as follows (in percentage by weight): glycerin 3.5%, dipropylene glycol 2%, trehalose 1%, horny goat weed extract 0.5%, acetyl tetrapeptide-11 0.05%, palmitoyl tripeptide-38 0.05%, sodium hyaluronate 0.05%, caprylic / capric triglyceride 4%, isononyl isononanoate 1.5%, phytosterol 0.1%, white pool seed oil 0.5%, emulsifier 2.4%, thickening stabilizer 0.5%, superoxide dismutase 0.01%, fullerene 0.1%, ergothioneine 0.05%, penetration regulator 0.5%, pH regulator 0.1%, preservative 0.45%, and the balance is deionized water.

[0085] The preparation method of the anti-aging skin composition of the present example is the same as that of example 1, and thus will not be repeated.

[0086] Example 5

[0087] The present example provides an anti-aging skin composition, which is different from example 1 in that the amount of each component is adjusted, and the rest remains unchanged. Specifically, the formula of the anti-aging skin composition is as follows (in percentage by weight): glycerin 3.5%, dipropylene glycol 2%, trehalose 1%, horny goat weed extract 0.5%, acetyl tetrapeptide-11 0.05%, palmitoyl tripeptide-38 0.05%, sodium hyaluronate 0.05%, caprylic / capric triglyceride 4%, isononyl isononanoate 1.5%, phytosterol 0.1%, white pool seed oil 0.5%, emulsifier 2.4%, thickening stabilizer 0.5%, superoxide dismutase 0.01%, fullerene 0.1%, ergothioneine 0.05%, penetration regulator 0.5%, pH regulator 0.1%, preservative 0.45%, and the balance is deionized water.

[0088] The preparation method of the anti-aging skin composition of the present example is the same as that of example 1, and thus will not be repeated.

[0089] Comparative Example 1

[0090] The present comparative example provides an anti-aging skin composition, which is different from example 1 in that no horny goat weed extract, acetyl tetrapeptide-11 and palmitoyl tripeptide-38 are added, and the same amount of deionized water is added to make up 100%, and the rest of the ingredients and the amount are the same as those of example 1. The corresponding preparation method can refer to example 1, and thus will not be repeated.

[0091] Comparative Example 2

[0092] The comparative example provides an anti-aging skin care composition, which does not add superoxide dismutase, fullerene and ergothioneine compared with Example 1, and is supplemented with an equal amount of deionized water to 100%, and the remaining ingredients and amounts are the same as those in Example 1. The corresponding preparation method can refer to Example 1, and thus will not be described here.

[0093] Comparative Example 3

[0094] The comparative example provides an anti-aging skin care composition, which is obtained by using the formula and preparation method of Example 1 in the invention patent application CN117159438A.

[0095] In order to verify the technical effect of the present application, the following performance test experiments were carried out.

[0096] 1. In vitro antioxidant capacity test (DPPH free radical scavenging rate)

[0097] 0.1 g of the sample prepared in Examples 1-5 and Comparative Examples 1-3 was mixed with 2.9 mL of DPPH ethanol solution (0.1 mM), and the absorbance was measured at 517 nm after 30 minutes of light-free reaction. The DPPH free radical scavenging rate was calculated, and the results are shown in Table 1.

[0098] Table 1: DPPH free radical scavenging rate

[0099] 2. Human efficacy evaluation

[0100] 60 healthy female volunteers aged 35-55 were recruited and randomly divided into 8 groups, and used the products of Example 1, Comparative Example 1, Comparative Example 2, Comparative Example 3, respectively, once in the morning and evening, for 28 consecutive days. Professional skin testing instruments were used for measurement.

[0101] Skin elasticity: R2 value (total elasticity) was measured using Cutometer.

[0102] Skin wrinkles: The area ratio of crow's feet at the corner of the eye was evaluated using Visioface image analysis system.

[0103] Skin moisture: The water content of the stratum corneum was measured using Corneometer CM825.

[0104] The results are expressed as the improvement rate after 28 days of use (compared with day 0), and the results are shown in Table 2.

[0105] Table 2: Human efficacy evaluation results (improvement rate % after 28 days of use)

[0106] 3. Stability test

[0107] The samples of Example 1 and Comparative Example 3 were placed in a 40°C incubator (accelerated test), a -15°C refrigerator (cold resistance test) and at room temperature (25°C), and their appearance, color, odor were observed and the pH value and viscosity changes were measured after 1 month, 3 months and 6 months of storage, respectively. At the same time, centrifugal experiments (4000 rpm, 30 min) were performed on all samples to evaluate their emulsion stability. The specific results are shown in Tables 3 and 4 below.

[0108] Table 3: Stability test results of Example 1 (initial pH 5.82, viscosity 25500 mPa·s)

[0109] Table 4: Stability test results of Comparative Example 3 (initial pH 5.9, viscosity 23800 mPa·s)

[0110] From the results of Tables 3 and 4, it can be seen that the sample of Example 1 exhibits excellent stability under various test conditions. After 6 months of accelerated testing at 40°C, only a slight color change occurs, the pH value and viscosity decrease slightly but the magnitude is very small, and the emulsion remains in good condition without separation. Under -15°C and room temperature conditions, all indicators are very stable.

[0111] The stability of the sample of Comparative Example 3 is significantly inferior to that of the present application. After 3 months of storage at 40°C, oil separation begins to occur, and after 6 months, obvious separation occurs. Under -15°C conditions, the cold resistance is very poor, and after multiple freeze-thaw cycles, particles appear and eventually lead to demulsification. After 6 months of storage at room temperature, slight bleeding also occurs.

[0112] Analyzing the results of the above tests, it can be known that:

[0113] (1) The anti-aging skin care compositions prepared in Examples 1-5 of the present application all exhibit excellent in vitro antioxidant capacity, significantly better than Comparative Example 2 which lacks core antioxidant ingredients and Comparative Example 3 of the prior art.

[0114] (2) Human efficacy evaluation shows that Example 1 of the present application has the most significant effect on improving skin elasticity, reducing wrinkles and increasing skin moisture, and is superior to Comparative Example 1 which lacks deep anti-aging ingredients, Comparative Example 2 which lacks antioxidant ingredients, and Comparative Example 3 of the prior art.

[0115] (3) Stability tests prove that the anti-aging skin care compositions of the present application, through the optimized formulation system and preparation process, have significantly better physical and chemical stability than the prior art, have good storage stability, can ensure the quality and efficacy of the product within the shelf life, and meet the needs of marketing.

[0116] In conclusion, the application builds a brand new, multi-pathway synergistic anti-aging system through multi-level, multi-target scientific formula design, and realizes excellent anti-aging, skin tendering and moisturizing effects through synergistic effect of each component, and the product is stable and safe.

[0117] The above embodiments only exemplarily illustrate the concept and technical solutions of the application, and are not used to limit the application. Any person skilled in the art can modify or change the above embodiments without departing from the spirit and category of the application. Therefore, all equivalent modifications or changes completed by those skilled in the art without departing from the spirit and technical idea disclosed by the application should be covered by the claims of the application.

[0118] In addition, it should be understood that although the present specification is described in terms of embodiments, not every embodiment contains only one independent technical solution, and the specification is described in this way only for the sake of clarity, and those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that those skilled in the art can understand.

Claims

1. An anti-aging and skin-rejuvenating composition, characterized in that, By weight percentage, it comprises the following components: glycerin 3.0%~8.0%, dipropylene glycol 2.0%~5.0%, trehalose 1.0%~3.0%, Cynomorium songaricum extract 0.5%~2.0%, acetyl tetrapeptide-11 0.05%~0.2%, palmitoyl tripeptide-38 0.05%~0.2%, sodium hyaluronate 0.05%~0.3%, caprylic / capric triglycerides 3.0%~10.0%, isononyl isononanoate 1.0%~5.0%, phytosterols 0.1%~0.5%, meadowfoam seed oil 0.5%~2.0%, emulsifier 2.4%~6%, thickener and stabilizer 0.5%~2.0%, superoxide dismutase 0.01%~0.1%, fullerene 0.1%~0.5%, ergothioneine 0.05%~0.2%, osmotic conditioner 0.5%~2.0%, pH adjuster 0.1%~0.3%, preservative 0.45%~1.2%, and the balance being deionized water.

2. The anti-aging and skin-rejuvenating composition according to claim 1, characterized in that, By weight percentage, it comprises the following components: glycerin 5%, dipropylene glycol 3%, trehalose 2%, Cynomorium songaricum extract 1%, acetyl tetrapeptide-11 0.1%, palmitoyl tripeptide-38 0.1%, sodium hyaluronate 0.1%, caprylic / capric triglyceride 6%, isononyl isononanoate 3%, phytosterols 0.2%, meadowfoam seed oil 1%, emulsifier 4%, thickener and stabilizer 1%, superoxide dismutase 0.05%, fullerene 0.3%, ergothioneine 0.1%, osmotic conditioner 1%, pH adjuster 0.2%, preservative 0.75%, and the balance being deionized water.

3. The anti-aging and skin-rejuvenating composition according to claim 1, characterized in that, The fullerene is a water-soluble fullerene.

4. The anti-aging and skin-rejuvenating composition according to claim 1, characterized in that, The emulsifier is composed of cetearyl oleate / sorbitan oleate and cetearyl oleate in a mass ratio of 3:

1.

5. The anti-aging and skin-rejuvenating composition according to claim 1, characterized in that, The thickening stabilizer is sodium acryloyl dimethyl taurate / VP copolymer.

6. The anti-aging and skin-rejuvenating composition according to claim 1, characterized in that, The osmotic regulator is trimethylglycine.

7. The anti-aging and skin-rejuvenating composition according to claim 1, characterized in that, The pH adjuster is at least one of citric acid, sodium benzoate, and potassium sorbate.

8. The anti-aging and skin-rejuvenating composition according to claim 1, characterized in that, The preservative is composed of 1,2-hexanediol and octyl glycol in a mass ratio of 2:

1.

9. A method for preparing an anti-aging and skin-rejuvenating composition according to any one of claims 1 to 8, characterized in that, Includes the following steps: S1. Mix deionized water, glycerin, dipropylene glycol, trehalose, sodium hyaluronate, and osmotic regulator, heat to 75℃~78℃, and stir homogenously to obtain the aqueous phase component; S2. Mix caprylic / capric triglyceride, isononyl isononanoate, emulsifier, phytosterol, and meadowfoam seed oil, and heat to 75℃~78℃ to dissolve, to obtain the oil phase component; S3. Add the oil phase component to the aqueous phase component under stirring, and perform high-speed homogenization and emulsification; S4. Cool down to below 45℃, add thickener and stabilizer, and stir well; S5. Continue cooling to below 40℃, then add Cynomorium extract, acetyl tetrapeptide-11, palmitoyl tripeptide-38, superoxide dismutase, fullerene, and ergothioneine in sequence, and stir well. S6. Add pH adjuster and preservative, and stir until completely homogeneous; S7. Cool down to below 30°C and discharge to obtain the anti-aging and skin-rejuvenating composition.

10. The preparation method according to claim 9, characterized in that, In step S3, the high-speed homogenization emulsification speed is 4000 rpm to 6000 rpm, and the time is 3 min to 6 min.

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