Dendrobium germ and ginseng powder solid beverage and preparation method thereof

Abstract

The invention relates to the field of solid beverages and preparation thereof, in particular to a dendrobium germ and ginseng powder solid beverage and a preparation method thereof.The dendrobium germ and ginseng powder solid beverage is prepared from brown sugar, sodium bicarbonate, Xinhui pericarpium citri reticulatae, dendrobium germs, ginseng and the like according to the specific mass percent, the dendrobium germs are subjected to symbiotic cultivation under the specific condition, and the ginseng is subjected to low-temperature fermentation treatment; amomum villosum extracts and the like can also be added, dosage forms such as powder, effervescent tablets and tea bags can be added, a corresponding preparation method is provided, and the raw materials are subjected to the steps of pretreatment, embedding treatment, total mixing, forming and sub-packaging and the like. The solid beverage has the effects of being beneficial to relieving stomach discomfort symptoms such as hyperacidity, stomachache and gasteremphraxis, improving the body leukocyte level, enhancing the immunity and improving fatigue and weakness caused by deficiency of qi and blood.

Description

Technical Field

[0001] This application relates to the field of solid beverages and their preparation, and in particular to a Dendrobium germ ginseng powder solid beverage and its preparation method. Background Technology

[0002] Stomach discomfort, such as acid reflux, stomach pain, bloating, nausea, vomiting, and acid regurgitation, not only severely impacts people's quality of life, preventing them from working and living normally, reducing work efficiency and happiness, but can also lead to more serious health problems like stomach ulcers and gastritis, causing immense suffering and increasing the medical burden on families and society. Therefore, developing products that alleviate stomach discomfort, enhance immunity, and regulate qi and blood is of vital practical significance for improving people's health. Solid beverages, as a highly convenient and portable form of product, are easy to store, transport, and use, fully meeting consumer needs in various scenarios. Whether traveling, working, studying, or in daily life, consumers can enjoy them anytime, anywhere. Furthermore, with the continuous advancement of food science and technology, more and more new food resources and medicinal substances are being discovered and applied to the research and development of solid beverages, providing more possibilities for product innovation and upgrading, and offering new ideas for solving stomach health problems. This not only helps promote the development of the food industry but also provides consumers with more high-quality and efficient health product choices.

[0003] In the traditional field of stomach health products, various methods are commonly used to alleviate symptoms such as stomach acid and stomach pain. One common approach is the use of antacids, such as sodium bicarbonate. Sodium bicarbonate can neutralize stomach acid, quickly relieving discomfort caused by excessive stomach acid. When there is excessive stomach acid secretion, taking products containing sodium bicarbonate can rapidly react with the stomach acid, reducing its irritation to the gastric mucosa and thus alleviating pain and discomfort. In addition, products containing ingredients such as dried tangerine peel are also common. Dried tangerine peel has the effect of regulating qi and strengthening the spleen, helping to relieve symptoms such as abdominal distension. The active ingredients in dried tangerine peel can promote gastrointestinal motility, enhance digestive function, and improve the digestive environment of the stomach. Some products also add traditional Chinese medicinal herbs such as ginseng. Ginseng has the effects of greatly replenishing vital energy, strengthening the spleen and benefiting the lungs, and can regulate gastrointestinal function. Ginsenosides and other components in ginseng can promote the proliferation of gastric mucosal cells, protect the gastric mucosa from damage, and regulate gastric acid secretion. Furthermore, some products on the market use common dendrobium, hoping to improve stomach health by utilizing its ability to promote gastric mucosal repair. Components such as Dendrobium polysaccharides in common Dendrobium have a certain protective and repairing effect on the gastric mucosa. These methods can alleviate stomach discomfort to some extent, but they often have limitations such as singular efficacy and inability to fundamentally solve stomach problems. For example, using antacids alone can only temporarily relieve the symptoms of excessive stomach acid and cannot repair damaged gastric mucosa; while products containing tangerine peel or ginseng can regulate gastrointestinal function to some extent, their effects on enhancing immunity and improving blood circulation are relatively weak.

[0004] However, traditional stomach health products have significant drawbacks. On one hand, the raw material sources and production processes of traditional products may be limited, resulting in low levels of active ingredients and difficulty in achieving ideal therapeutic effects. For example, the content of active ingredients in common Dendrobium officinale on the market is relatively low, with extracts below 10% and oligosaccharide content only 3-5%, failing to fully exert its effects such as promoting gastric mucosal repair. Furthermore, the production process of common Dendrobium officinale is prone to contamination by heavy metals, pesticides, and antibiotics, compromising food safety. Traditional Dendrobium officinale cultivation methods may use pesticides to control pests and diseases, and the plant is also susceptible to heavy metal contamination from the soil during growth. These harmful substances remain in the Dendrobium officinale, posing a potential threat to human health. On the other hand, traditional products often fail to achieve synergistic effects across multiple functions, making it difficult to address both the symptoms and the root cause. They cannot comprehensively enhance the body's immunity or regulate Qi and blood and gastrointestinal function. When dealing with stomach discomfort, traditional products typically only alleviate a single symptom, failing to improve overall stomach health or resolve other problems caused by low immunity or insufficient Qi and blood. For example, some products can only relieve stomach pain symptoms, but they are powerless to enhance the body's immunity or improve blood and qi deficiency, and cannot fundamentally improve the body's health. Summary of the Invention

[0005] The purpose of this application is to overcome the above-mentioned technical problems and provide a Dendrobium germ ginseng powder solid beverage and its preparation method.

[0006] A solid beverage containing Dendrobium officinale germ and ginseng powder, comprising, by weight percentage: 55%-65% brown sugar, 15%-22% sodium bicarbonate, 5%-10% Xinhui tangerine peel, 5%-10% Dendrobium officinale germ, and 5%-9% ginseng; wherein the Dendrobium officinale germ is obtained from the protocorms of Dendrobium officinale through symbiotic cultivation with a strain of *Dendrobium*, under the following cultivation conditions: 0.4-0.6 mg / L of *Dendrobium officinale* germ is added to the culture medium. 6-Benzylaminopurine (6-BA) and 0.15-0.25 mg / L naphthaleneacetic acid (NAA), with glucose and sucrose mixed at a ratio of 1.8:1-2.2:1 as the carbon source, under a light intensity of 1200-1800 lux, for a cultivation period of 45-60 days, and the oligosaccharide content of the Dendrobium embryo is ≥30% and the extract content is ≥50%; the ginseng is artificially cultivated ginseng less than five years old, which is fermented at a low temperature of 35-45℃ for 24-36 hours, and its total content of rare saponins Rg3 and Rh2 is ≥0.3%.

[0007] By adopting the above technical solutions, the sodium bicarbonate used in this solid beverage can quickly relieve acute stomach discomfort caused by excessive gastric acid; brown sugar can warm and nourish the spleen and stomach, harmonize the properties of other medicines, and relieve dull pain caused by deficiency and cold; combined with ginseng, it achieves "dual replenishment of qi and blood," enhancing the body's disease resistance and recovery ability; Xinhui tangerine peel helps relieve abdominal distension, inhibits gastric mucosal inflammation, and promotes digestive juice secretion; combined with tissue-cultured Dendrobium officinale protocorms, it can nourish stomach yin, regulate qi and eliminate dampness, quickly reduce stomach fire, regulate stomach qi, and promote gastrointestinal motility; tissue-cultured Dendrobium officinale protocorms, cultivated under specific conditions, contain Dendrobium polysaccharides and alkaloids, which can promote gastric mucosal repair, relieve burning pain and dry mouth caused by insufficient stomach yin, and have anti-ulcer effects, targeting chronic gastritis and ulcers. For mucosal damage, it can enhance the gastric barrier function. Its oligomeric polysaccharides are small and fast-acting, and can quickly repair damaged gastric mucosa. Its polysaccharide components have shown regulatory activity on immune cells in in vitro studies. Ginseng processed by low-temperature fermentation contains ginsenosides, which can promote the proliferation of gastric mucosal cells, protect the gastric mucosa from damage, regulate gastric acid secretion, and may have a certain inhibitory effect on Helicobacter pylori. It can improve indigestion caused by spleen and stomach weakness. It works synergistically with tissue-cultured Dendrobium officinale protocorms to achieve "dual replenishment of qi and yin", repair insufficient gastric motility. Its rare saponin molecules are small and fast-acting, and can quickly repair the gastric mucosa, help maintain normal immune response, and solve problems such as headache, dizziness, palpitations, fatigue, and lack of energy caused by insufficient blood supply or anemia. Overall, this solid beverage can enhance the gastric mucosal barrier function, promote gastric mucosal cell regeneration, and repair damaged gastric mucosa. It is beneficial in relieving and improving discomforts such as stomach pain, bloating, nausea, vomiting, and acid reflux caused by gastritis, thus reducing patient suffering. It can also inhibit gastric mucosal inflammation, regulate gastric acid secretion, and may have a certain auxiliary effect on inhibiting Helicobacter pylori, thus improving indigestion. It can increase white blood cell levels, enhance the body's immunity, and may have a certain alleviating effect on some discomforts caused by low immunity or immune system disorders. It can achieve dual replenishment of qi and blood, and balance yin and yang, thus improving symptoms of insufficient blood supply or anemia. It can also regulate gastrointestinal motility, reduce stomach fire, regulate stomach qi, solve problems such as dry mouth, bitter taste, and constipation, and promote digestion and absorption.

[0008] Preferably, the optimal ratio of the raw materials by mass percentage is: 60% brown sugar, 18% sodium bicarbonate, 8% Xinhui tangerine peel, 7% Dendrobium germ, and 7% ginseng; the *Tulasnella* strain is a *Tulasnella* sp. strain, and during the symbiotic cultivation process, the inoculation amount of the strain is 0.5%-1.0% of the culture medium mass, and the relative humidity of the cultivation environment is controlled at 60%-70%.

[0009] Preferably, the raw materials further include 1.5%-2.5% of Amomum villosum extract; the preparation process of the Amomum villosum extract is as follows: using dried Amomum villosum fruit from Yangchun as raw material, supercritical CO2 extraction is adopted, the extraction pressure is 20-25MPa, the extraction temperature is 40-45℃, and the extraction time is 1.5-2.0 hours. After extraction, the volatile oil is removed by molecular distillation, the volatile oil removal rate is ≥90%, and the retention rate of bornyl acetate is ≥95%.

[0010] Preferably, the brown sugar is replaced with 4%-6% erythritol, and 5%-7% citric acid and 3%-5% povidone K30 are added to the raw materials to form an effervescent tablet. The performance parameters of the effervescent tablet are: tablet hardness 4-6 kg, disintegration time 25-35 seconds, and after dissolving in 100 mL of purified water at 25°C, the solution pH value is 5.5-6.5, and there are no visible insoluble substances.

[0011] Preferably, the raw materials also include 8%-12% maltodextrin. After mixing the raw materials, they are made into slow-release granules and packaged in corn fiber triangular filter bags to form a tea bag dosage form. The preparation process of the slow-release granules is as follows: the mixed powder and maltodextrin are mixed at a mass ratio of 8-10:1, 20%-30% ethanol solution is added to make a soft mass, granulated by passing through a 14-16 mesh sieve, and dried at 50-55℃ until the moisture content is ≤5%. The performance parameters of the tea bag dosage form are: when soaked in 200mL of 85-95℃ hot water at 25℃ for 2.5-3.5 minutes, the extraction rate of effective ingredients (Dendrobium oligosaccharides, ginsenoside Rg1) is ≥85%. A method for preparing a solid beverage of Dendrobium officinale germ and ginseng powder includes the following steps: S1. Raw material pretreatment: Dendrobium officinale germ, ginseng, and Xinhui tangerine peel are processed separately using a low-temperature pulverization process at a pulverization temperature of 5-15℃. After pulverization, the powder is passed through a 70-90 mesh sieve to obtain medicinal powder. If the raw material contains Amomum villosum extract, the Amomum villosum extract is mixed with the medicinal powder and stirred for 10-15 minutes until homogeneous. S2. If component encapsulation is required, the Amomum villosum extract is encapsulated separately using hydroxypropyl methylcellulose (HPMC) thermosensitive encapsulation material with a wall thickness of 1.2-1.8 μm. Sodium bicarbonate is mixed with Dendrobium officinale germ powder and ginseng powder and encapsulated using ethyl cellulose (EC) pH... Response material encapsulation, capsule wall thickness 3.5-4.5μm; Dendrobium germ powder and ginseng powder are mixed, and sodium alginate-pH responsive material is used for encapsulation, capsule wall thickness 3.5-4.5μm; after encapsulation, it is passed through an 18-22 mesh sieve to remove agglomerated particles, obtaining encapsulated particles; S3. Total mixing: The medicinal powder from step S1 or the encapsulated particles from step S2 are added to a three-dimensional mixer with brown sugar (or erythritol) and the remaining raw materials, the mixing speed is 15-20 r / min, the total mixing time is 25-35 minutes, and the mixture is passed through an 8-12 mesh sieve 1-2 times during the mixing process. The mixing uniformity is ensured to be ≥96% by online near-infrared spectroscopy monitoring, and a mixed powder is obtained. S4. Molding and Packaging: - For powder dosage form: Fill the mixed powder into bags at a specification of 1.5-2.5g / bag, using an oxide isolation film for packaging, with the humidity inside the packaging controlled at ≤12%-18%; - For effervescent tablets: Mix the mixed powder with povidone K30 and citric acid to form granules, pass them through a 16-20 mesh sieve for granulation, compress them into tablets under a pressure of 12-15MPa, and dry them at 55-60℃ for 1-1.5 hours after compression to remove residual moisture; - For tea bag dosage form: After the mixed powder is made into slow-release granules, package them into corn fiber triangular filter bags at a specification of 2.0-2.5g / bag, using ultrasonic sealing, with a sealing strength ≥5N / 15mm.

[0012] By adopting the above technical solutions, the low-temperature pulverization process treats Dendrobium officinale embryos, ginseng, and Xinhui tangerine peel at 5-15℃, which can prevent the effective components in the raw materials from being destroyed by high temperatures. Passing through a 70-90 mesh sieve ensures that the particle size of the raw materials is moderate, which is conducive to subsequent mixing and dissolution. If there is Amomum villosum extract, stirring for 10-15 minutes can ensure that it is fully and evenly mixed with the herbal powder. Using hydroxypropyl methylcellulose (HPMC) thermosensitive capsule material to embed sodium bicarbonate and Amomum villosum extract with a capsule wall thickness of 1.2-1.8μm can achieve targeted drug release at specific temperatures. Sodium alginate-pH responsive capsule material to embed Dendrobium officinale embryo powder and ginseng powder with a capsule wall thickness of 3.5-4.5μm can release drugs under different pH environments. Passing through an 18-22 mesh sieve removes agglomerated particles and ensures the uniformity of the embedded particles. The three-dimensional mixer mixes materials at a speed of 15-20 r / min and a total mixing time of 25-35 minutes. During the process, the mixture is passed through an 8-12 mesh sieve 1-2 times, and online near-infrared spectroscopy monitoring is used to ensure that the mixing uniformity is ≥96%, so that all raw materials are fully mixed and the product quality is stable. For powder dosage forms, they are filled in 1.5-2.5g / bag specifications, using PET / AL / PE composite film with an oxygen permeability ≤5cm³ / (m²·24h·0.1MPa), a water vapor permeability ≤2g / (m²·24h), and a film thickness of 80-100μm. This effectively isolates oxygen and water vapor, controls the humidity inside the packaging to ≤12%-18%, and prevents the product from absorbing moisture, clumping, and deteriorating. Effervescent tablets undergo granulation, sizing, compression, and drying processes to ensure a tablet hardness of 4-6kg, a disintegration time of 25-35 seconds, and a solution pH of 5.5-6.5 after dissolving in 100mL of purified water at 25℃, with no visible insoluble matter. For tea bag dosage forms, the mixed powder is made into sustained-release granules and packaged in corn fiber triangular filter bags in 2.0-2.5g / bag specifications. Ultrasonic sealing with a sealing strength ≥5N / 15mm is used, ensuring a safe dissolution rate of 200mL at 25℃. When soaked in hot water at 85-95℃ for 2.5-3.5 minutes, the extraction rate of active ingredients (Dendrobium oligosaccharides and ginsenoside Rg1) is ≥85%. The resulting solid beverage aims to relieve and improve discomfort such as stomach pain, bloating, nausea, vomiting, and acid reflux caused by gastritis, reducing patient suffering; it may also help inhibit gastric mucosal inflammation, regulate gastric acid secretion, and improve indigestion; its component combination may help support the normal function of the body's immune system; it achieves dual replenishment of qi and blood, balancing yin and yang, improving symptoms of insufficient blood supply or anemia; it regulates gastrointestinal motility, reduces stomach fire, regulates stomach qi, solves problems such as dry mouth, bitter taste, and constipation, and promotes digestion and absorption.

[0013] Preferably, in step S2, the raw materials for preparing the temperature-sensitive capsule material are HPMC and polyethylene glycol 400 mixed at a mass ratio of 9-10:1; the raw materials for preparing the pH-responsive capsule material are sodium alginate and chitosan mixed at a mass ratio of 8-9:1, and the encapsulation process adopts spray drying method with an inlet air temperature of 180-200℃ and an outlet air temperature of 80-90℃.

[0014] Preferably, in step S3, the characteristic wavelengths of the online near-infrared spectroscopy monitoring are: 1200-1250nm for Dendrobium oligosaccharides and 1600-1650nm for ginsenoside Rg1. Spectral data are collected every 5 minutes, and the relative standard deviation (RSD) of the components is calculated. When RSD ≤ 2.0%, the mixture is considered to be uniform.

[0015] Preferably, in step S4, the oxide separator is a PET / AL / PE composite membrane with a thickness of 80-100 μm, an oxygen permeability of ≤5 cm³ / (m²·24h·0.1 MPa), and a water vapor permeability of ≤2 g / (m²·24h).

[0016] Preferably, the solid beverage is used to relieve stomach discomfort symptoms such as excessive stomach acid, stomach pain, and bloating, and its composition may help support the normal function of the body's immune system and improve fatigue and weakness caused by insufficient qi and blood. The solid beverage is consumed as follows: the powder is mixed with 100-150mL of warm water at 40-60℃, the effervescent tablets are dissolved directly in 100-150mL of room temperature water, and the tea bag is steeped in 200mL of hot water at 85-95℃. The daily dosage is 1-2 packets (tablets / packets), and it is recommended to consume it 1-2 hours after meals.

[0017] In summary, this application includes at least one of the following beneficial technical effects: 1. It uses Dendrobium officinale embryos cultivated symbiotically with *Dendrobium* strains and ginseng less than five years old fermented at low temperatures. These raw materials have high content of effective components, which can enhance the gastric mucosal barrier function, promote gastric mucosal cell regeneration, and quickly and efficiently repair damaged gastric mucosa, effectively relieving and improving discomfort symptoms such as stomach pain, bloating, nausea, vomiting, and acid reflux caused by gastritis, reducing patient suffering; at the same time, it inhibits gastric mucosal inflammation, regulates gastric acid secretion, and may have a certain auxiliary effect on the inhibition of Helicobacter pylori, improving indigestion; 2. The combination of Dendrobium officinale embryos and ginseng can increase white blood cell levels, enhance the body's immunity, and may have a certain relieving effect on some discomfort caused by low immunity or immune system disorders; 3. The combination of raw materials can achieve dual replenishment of qi and blood, and balance yin and yang, improving symptoms of insufficient blood supply or anemia; regulating gastrointestinal motility, reducing stomach fire, regulating stomach qi, solving problems such as dry mouth, bitter taste, and constipation, and promoting digestion. 4. The raw material ratio and process parameters are all set within a reasonable range, ensuring that the product efficacy meets the standards and regulatory requirements, while also being suitable for industrial production, balancing efficacy and cost, and guaranteeing the product's cost-effectiveness and the pass rate of mass production; 5. The addition of Amomum villosum extract to the raw materials works synergistically with other raw materials to enhance the gastrointestinal motility effect; its preparation process can effectively remove volatile oils and retain hesperidin, improving product performance; 6. The product is available in three dosage forms: powder, effervescent tablets, and tea bags, which can meet the needs of consumers in different scenarios; the effervescent tablets have a good taste and are convenient to take, while the tea bags are convenient to carry and brew; 7. The encapsulation treatment in the preparation method can achieve targeted release of the ingredients and prolong the duration of drug action; online near-infrared spectroscopy monitoring ensures the uniformity of mixing and guarantees the stability of product quality; 8. The product uses oxide isolation film packaging or ultrasonic sealing, which can effectively protect the product, extend the shelf life, and ensure the stability of the product during storage and transportation. Detailed Implementation

[0018] The technical solutions in the embodiments of the present invention are further described in detail below. The described embodiments are merely possible technical implementations of the present invention, and are not limited thereto. Those skilled in the art can certainly combine the embodiments of the present invention to obtain other embodiments without creative effort, which are also within the protection scope of the present invention.

[0019] This application mainly uses a variety of raw materials in a scientific ratio to make a solid beverage, which achieves the effects of relieving stomach discomfort, enhancing immunity, and improving blood circulation. The following is a further detailed description of this application.

[0020] Example 1: The Dendrobium officinale germ and ginseng powder solid beverage provided in this application includes raw materials such as brown sugar, sodium bicarbonate, Xinhui tangerine peel, Dendrobium officinale germ, and ginseng. These raw materials are rationally combined in weight percentages to alleviate various stomach discomfort symptoms such as stomach acid and stomach pain, while also enhancing immunity, repairing the gastric mucosa, and improving blood circulation. This is because each raw material has unique effects, and their combined action can exert a synergistic effect. Specifically, the Dendrobium officinale germ is obtained from the protocorm of Dendrobium officinale through symbiotic cultivation with a strain of the genus *Dendrobium*. The cultivation conditions are relatively strict, with the culture medium containing 0.4-0.6 mg / L 6-benzylaminopurine (6-BA) and 0.15-0.25 mg / L naphthaleneacetic acid (NAA). These two substances provide necessary nutrition and growth regulation for the Dendrobium officinale germ. The carbon source is a mixture of glucose and sucrose at a ratio of 1.8:1-2.2:1; this appropriate carbon source ratio meets the energy requirements for the growth of the Dendrobium officinale germ. A light intensity of 1200-1800 lux provides suitable light conditions for the photosynthesis of Dendrobium officinale embryos. A cultivation cycle of 45-60 days ensures sufficient time for the embryos to grow and develop. This cultivation method results in an oligosaccharide content of ≥30% and an extract content of ≥50% in the Dendrobium officinale embryos, significantly increasing the content of its active ingredients compared to ordinary Dendrobium. For example, the extract content of ordinary Dendrobium is less than 10%, and the oligosaccharide content is only 3-5%. During the cultivation process, the *Dendrobium* strains can be replaced with other symbiotic bacteria beneficial to Dendrobium growth, as long as they can promote the growth of the embryos and increase the content of active ingredients.

[0021] Preferably, stem segments from aseptic seedlings of *Dendrobium officinale* were used as explants and inoculated onto MS solid medium supplemented with *Dendrobium* strains for protocorm induction and symbiotic cultivation, with a total culture period of 50 days. The medium contained 0.5 mg / L 6-benzylaminopurine (6-BA) and 0.2 mg / L naphthaleneacetic acid (NAA), with glucose and sucrose mixed in a 2:1 ratio as the carbon source, and a sucrose concentration of 30 g / L. The culture conditions were: light intensity 1500 lux, photoperiod 12 h / d, temperature 25 ± 2℃, inoculum size 0.8% of the medium mass, and relative humidity 65%.

[0022] Sterilization and Testing: After cultivation, the protocorms were removed, rinsed thoroughly with clean water, and pasteurized in a 60℃ oven for 30 minutes. After cooling, random samples were taken for microbial limit testing using the plate count method, requiring a total bacterial count ≤1000 CFU / g, molds and yeasts ≤100 CFU / g, and no detectable coliforms. After passing the test, the protocorms were vacuum-dried at 45℃ until the moisture content was ≤8%, and then pulverized through a 100-mesh sieve using an ultrafine pulverizer to obtain tissue-cultured Dendrobium officinale protocorm powder. The oligosaccharide content was 32.5% and the extract content was 53.8%, as determined by HPLC.

[0023] The ginseng used is artificially cultivated ginseng less than five years old, which undergoes low-temperature fermentation at 35-45℃ for 24-36 hours. Low-temperature fermentation ensures that the total content of rare saponins Rg3 and Rh2 in the ginseng is ≥0.3%. These rare saponins have effects such as rapidly repairing the gastric mucosa and enhancing immunity. Artificially cultivated ginseng less than five years old is widely available and its safety is guaranteed. Other ginseng varieties that meet edible standards can also be used, as long as they achieve similar effects through appropriate processing.

[0024] Xinhui tangerine peel has the effects of regulating qi and strengthening the spleen, drying dampness and resolving phlegm. It helps relieve symptoms of abdominal distension and can also promote the secretion of digestive juices, aiding digestion and absorption. It is rich in hesperidin, which has a good inhibitory effect on gastric mucosal inflammation. In the formula, Xinhui tangerine peel can be replaced with other Chinese medicinal materials with similar qi-regulating and spleen-strengthening effects, such as green tangerine peel.

[0025] Brown sugar has the effects of warming and nourishing the spleen and stomach, harmonizing the properties of other medicines, and relieving dull pain caused by deficiency and cold. When combined with ginseng, it can achieve "dual nourishment of qi and blood," enhancing the body's disease resistance and recovery capabilities. Brown sugar can also be replaced with other sugars with similar warming and nourishing effects, such as black sugar.

[0026] Sodium bicarbonate, as an excipient, can quickly relieve acute stomach discomfort caused by excessive stomach acid. It neutralizes stomach acid, reducing its concentration and lessening its irritation to the gastric mucosa. Together, these ingredients work synergistically: Dendrobium officinale germ promotes gastric mucosal repair; ginseng enhances immunity and regulates gastrointestinal function; Xinhui tangerine peel regulates qi, strengthens the spleen, and promotes digestion; brown sugar warms and nourishes the spleen and stomach and harmonizes the medicinal properties; and sodium bicarbonate quickly relieves excessive stomach acid. Together, they achieve a comprehensive effect of relieving stomach discomfort, enhancing immunity, and improving blood circulation.

[0027] By weight percentage, the raw materials should contain 55%-65% brown sugar. If it is less than 55%, the warming and nourishing effects will be insufficient, and if it is more than 65%, it will easily absorb moisture and clump. Sodium bicarbonate should contain 15%-22%. If it is less than 15%, it will not be able to quickly neutralize stomach acid, and if it is more than 22%, it will easily lead to bloating and excessive sodium intake. Xinhui tangerine peel should contain 5%-10%. If it is less than 5%, the effects of regulating qi and strengthening the spleen will be weak, and if it is more than 10%, it will easily produce a bitter taste due to the high content of volatile oils. Dendrobium germ should contain 5%-10%. If it is less than 5%, the total amount of active ingredients will be insufficient, and if it is more than 10%, it will increase costs and there will be no significant synergy of effects. Ginseng should contain 5%-9%. If it is less than 5%, the content of ginsenosides will be insufficient, and if it is more than 9%, it will easily cause the side effect of "heatiness".

[0028] Before crushing and mixing, turn on the workshop dehumidification equipment to ensure that the ambient humidity is ≤30%. The tissue-cultured Dendrobium officinale protocorms, after symbiotic cultivation, are pasteurized at 60℃ for 30 minutes. After cooling, samples are taken for microbial limit testing. Random samples are required to perform microbial limit testing after cooling using the plate count method. The total bacterial count must be ≤1000 CFU / g, mold and yeast ≤100 CFU / g, and coliforms must not be detected. Only after passing the test can the next process proceed. The implementation principle of this embodiment is as follows: This Dendrobium germ and ginseng powder solid beverage uses Dendrobium germ cultivated using a specific method and ginseng fermented at low temperatures, combined with raw materials such as Xinhui tangerine peel, brown sugar, and sodium bicarbonate. The effects of each raw material are synergistic. It utilizes the immune-boosting and gastric mucosa-repairing effects of Dendrobium germ and ginseng, while also leveraging the qi-regulating and spleen-strengthening effects of Xinhui tangerine peel, the warming and stomach-tonifying effects of brown sugar, and the stomach acid-neutralizing effects of sodium bicarbonate. This overcomes the shortcomings of traditional stomach health products, such as single efficacy and low content of effective ingredients. It can improve stomach health from multiple aspects, while also enhancing the body's immunity and improving qi and blood, providing consumers with a more effective stomach health product. Example

[0029] The difference between this embodiment and the previous embodiment lies in the optimal ratio of raw materials and the more detailed requirements for the symbiotic cultivation of Dendrobium officinale embryos. The optimal ratio of raw materials by mass percentage is: 60% brown sugar, 18% sodium bicarbonate, 8% Xinhui tangerine peel, 7% Dendrobium officinale embryos, and 7% ginseng.

[0030] At this ratio, the efficacy of each ingredient can be fully utilized, achieving the best synergistic effect. The *Tulasnella* sp. strain is used. During the symbiotic cultivation process, the inoculum size is 0.5%-1.0% of the culture medium mass, and the relative humidity of the cultivation environment is controlled at 60%-70%. Appropriate inoculum size and relative humidity provide a favorable environment for the growth of *Dendrobium* embryos, promoting their growth and the accumulation of active ingredients.

[0031] The implementation principle of this embodiment is as follows: By determining the optimal ratio of raw materials, this embodiment can achieve the best synergistic effect of each raw material, further improving the product's efficacy. Simultaneously, the refinement of the symbiotic cultivation conditions for Dendrobium officinale embryos ensures the stability of the quality and content of active ingredients in the Dendrobium officinale embryos, thereby improving the overall quality and reliability of the product. Compared to traditional products, it can more effectively relieve stomach discomfort, enhance immunity, and improve blood circulation. Example

[0032] The difference between this embodiment and the above embodiment is that the raw materials also include 1.5%-2.5% of Amomum villosum extract. Amomum villosum extract has the effect of promoting gastrointestinal motility and can work synergistically with other raw materials to better regulate gastrointestinal function.

[0033] The preparation process of Amomum villosum extract is as follows: using dried Amomum villosum fruit from Yangchun as raw material, supercritical CO2 extraction is employed at an extraction pressure of 20-25 MPa, an extraction temperature of 40-45℃, and an extraction time of 1.5-2.0 hours. Supercritical CO2 extraction can efficiently extract the effective components from Amomum villosum while ensuring the purity and activity of the extract. After extraction, volatile oils are removed by molecular distillation, with a volatile oil removal rate ≥90% and a bornyl acetate retention rate ≥95%. Removing volatile oils reduces the irritating odor of the extract, while retaining hesperidin preserves its protective and conditioning effects on the gastric mucosa.

[0034] The implementation principle of this embodiment is as follows: The addition of Amomum villosum extract further enriches the product's efficacy. The gastrointestinal motility-promoting effect of Amomum villosum extract synergizes with the efficacy of other ingredients, providing a more comprehensive regulation of gastrointestinal function and enhancing the product's relief of stomach discomfort. Simultaneously, advanced preparation processes ensure the quality and effectiveness of the extract, improving the overall performance of the product and giving it a stronger competitive edge compared to traditional products. Example

[0035] The difference between this embodiment and the previous embodiment is that brown sugar is replaced with 4%-6% erythritol, and 5%-7% citric acid and 3%-5% povidone K30 are added to the raw materials to form an effervescent tablet. Erythritol is a sugar substitute with moderate sweetness and a refreshing taste, providing a certain level of sweetness while avoiding the high-calorie problem associated with traditional sugars. Citric acid, as an effervescent acid source, reacts with sodium bicarbonate, causing the effervescent tablet to rapidly disintegrate in water, producing bubbles, increasing the product's appeal and ease of use. Povidone K30 acts as a binder, ensuring the effervescent tablet's shape and hardness. The performance parameters of the effervescent tablet are: tablet hardness 4-6 kg, disintegration time 25-35 seconds, and a solution pH of 5.5-6.5 after dissolving in 100 mL of purified water at 25°C, with no visible insoluble matter. Appropriate tablet hardness ensures the effervescent tablet is not easily broken during storage and transportation, and the disintegration time ensures rapid onset of action without excessively generating a large number of bubbles that could negatively impact the user experience. A suitable solution pH value can ensure that the product has minimal irritation to the gastric mucosa.

[0036] The implementation principle of this embodiment is as follows: This embodiment formulates the product into effervescent tablets, making it convenient for consumers to take, especially in situations such as when out and about. The rational use of erythritol, citric acid, and povidone K30 ensures the quality and performance of the effervescent tablets. At the same time, the effervescent tablet form allows the product to disperse rapidly in water, enabling faster release and absorption of the active ingredients, improving the product's bioavailability, and providing a better user experience and effect compared to traditional powder formulations. Example

[0037] The difference between this embodiment and the previous embodiment is that the raw materials also include 8%-12% maltodextrin. After mixing the raw materials, sustained-release granules are formed and packaged in corn fiber triangular filter bags to form a tea bag dosage form. Maltodextrin, as the carrier of the sustained-release granules, allows for the slow release of the active ingredients in the product, prolonging the therapeutic effect. The corn fiber triangular filter bag has good air permeability and filtration properties, ensuring the leaching of active ingredients during the steeping process while filtering out impurities. The preparation process of the sustained-release granules is as follows: the mixed powder and maltodextrin are mixed at a mass ratio of 8-10:1, a 20%-30% ethanol solution is added to form a soft mass, granulated through a 14-16 mesh sieve, and dried at 50-55℃ until the moisture content is ≤5%. This preparation process ensures the formation and stability of the sustained-release granules, as well as the retention of the active ingredients. The performance parameters of the tea bag dosage form are as follows: when steeped in 200mL of 85-95℃ hot water at 25℃ for 2.5-3.5 minutes, the extraction rate of active ingredients (Dendrobium oligosaccharides and ginsenoside Rg1) is ≥85%. Appropriate steeping time and temperature ensure the full extraction of active ingredients, meeting consumers' needs for product efficacy.

[0038] The implementation principle of this embodiment is as follows: This embodiment formulates the product into a tea bag dosage form, providing a consumption method that is more in line with traditional tea drinking habits. The design of the sustained-release granules and tea bags allows the product to slowly release its active ingredients during steeping, prolonging the duration of its medicinal effect. At the same time, the tea bag dosage form is easy to carry and store, suitable for use in different scenarios, and meets the diverse needs of consumers, giving it unique advantages compared to other dosage forms. Example

[0039] The preparation method of Dendrobium germ ginseng powder solid beverage provided in this application includes the following steps: S1. Raw Material Pretreatment: Dendrobium officinale embryos, ginseng, and Xinhui tangerine peel are processed using a low-temperature pulverization process at 5-15℃. Low-temperature pulverization reduces the loss of active ingredients in the raw materials, ensuring their quality. After pulverization, the powder is passed through a 70-90 mesh sieve. If the raw materials contain Amomum villosum extract, the extract is mixed with the powder and stirred for 10-15 minutes until homogeneous. Thorough stirring ensures complete mixing of the extract and powder, guaranteeing the uniformity of the product's components.

[0040] S2. Encapsulation Treatment (Optional): If component encapsulation is required, the Amomum villosum extract is encapsulated alone using hydroxypropyl methylcellulose (HPMC) thermosensitive encapsulation material with a wall thickness of 1.2-1.8 μm; sodium bicarbonate is mixed with Dendrobium officinale germ powder and ginseng powder and encapsulated using ethyl cellulose (EC) pH-responsive encapsulation material with a wall thickness of 3.5-4.5 μm. Thermosensitive encapsulation material can control the release of components according to temperature changes, rapidly releasing the active ingredients at suitable temperatures. Dendrobium officinale germ powder and ginseng powder are mixed and encapsulated using sodium alginate-pH-responsive encapsulation material with a wall thickness of 3.5-4.5 μm. pH-responsive encapsulation material can control the release of components according to changes in the pH value of the gastrointestinal tract, ensuring that the active ingredients exert their effects at specific sites in the gastrointestinal tract. After encapsulation, the particles are passed through an 18-22 mesh sieve to remove agglomerated particles, obtaining encapsulated particles. Sieving ensures the uniformity and quality of the encapsulated particles.

[0041] S3. Final Mixing: Add the herbal powder from step S1 or the encapsulated granules from step S2, along with brown sugar (or erythritol) and the remaining ingredients to a three-dimensional mixer. Mix at 15-20 rpm for 25-35 minutes. Appropriate mixing speed and time ensure thorough and uniform mixing of all ingredients. During mixing, pass the mixture through an 8-12 mesh sieve 1-2 times. Online near-infrared spectroscopy monitoring ensures a mixing uniformity ≥96%, yielding a mixed powder. Online near-infrared spectroscopy monitoring allows real-time monitoring of the content and uniformity of each component during mixing, ensuring product quality stability.

[0042] S4. Forming and Packaging: For powder dosage form: The mixed powder is filled into 1.5-2.5g / bags using an oxide separator film, with the humidity inside the packaging controlled at ≤12%-18%. Appropriate packaging specifications and humidity control ensure the quality and stability of the powder, preventing moisture absorption and deterioration. For effervescent tablets: The mixed powder is mixed with povidone K30 and citric acid, granulated, and sieved through a 16-20 mesh sieve. The granules are then compressed into tablets under 12-15MPa pressure, and dried at 55-60℃ for 1-1.5 hours to remove residual moisture. This process ensures the formation and quality of the effervescent tablets, and removing residual moisture improves their stability and shelf life. For tea bag dosage form: The mixed powder is made into slow-release granules and packaged in corn fiber triangular filter bags at 2.0-2.5g / bag specifications. Ultrasonic sealing is used, with a sealing strength ≥5N / 15mm. Appropriate packaging specifications and sealing strength ensure the airtightness and quality of the tea bags, preventing leakage of active ingredients.

[0043] The implementation principle of this embodiment is as follows: The preparation method of this embodiment ensures the quality and stability of the product through strict raw material pretreatment, encapsulation, total mixing, molding, and packaging steps. The preparation processes for different dosage forms can meet the diverse needs of consumers. At the same time, the application of advanced technologies such as online near-infrared spectroscopy monitoring improves the accuracy and reliability of product quality control, and compared with traditional preparation methods, it can better guarantee the efficacy and safety of the product.

[0044] The above are all preferred embodiments of this application, and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A solid beverage made from Dendrobium germ and ginseng powder, characterized in that, By weight percentage, the raw material composition includes: 55%-65% brown sugar, 15%-22% sodium bicarbonate, 5%-10% Xinhui tangerine peel, 5%-10% Dendrobium officinale embryo, and 5%-9% ginseng; the Dendrobium officinale embryo is obtained from the protocorm of Dendrobium officinale through symbiotic cultivation with a strain of the genus *Dendrobium*, under the following cultivation conditions: 0.4-0.6 mg / L of *Dendrobium officinale* added to the culture medium. 6-Benzylaminopurine (6-BA) and 0.15-0.25 mg / L naphthaleneacetic acid (NAA), with glucose and sucrose mixed at a ratio of 1.8:1-2.2:1 as the carbon source, under a light intensity of 1200-1800 lux, for a cultivation period of 45-60 days, and the oligosaccharide content of the Dendrobium embryo is ≥30% and the extract content is ≥50%; the ginseng is artificially cultivated ginseng less than five years old, which is fermented at a low temperature of 35-45℃ for 24-36 hours, and its total content of rare saponins Rg3 and Rh2 is ≥0.3%.

2. The Dendrobium germ and ginseng powder solid beverage according to claim 1, characterized in that, The optimal proportion of the raw materials, by weight percentage, is: 60% brown sugar, 18% sodium bicarbonate, 8% Xinhui tangerine peel, 7% dendrobium germ, and 7% ginseng; the strain of the genus Tulasnella is Tulasnella sp., and during the symbiotic cultivation process, the inoculum amount of the strain is 0.5%-1.0% of the culture medium mass, and the relative humidity of the cultivation environment is controlled at 60%-70%.

3. The Dendrobium germ and ginseng powder solid beverage according to claim 1, characterized in that, The raw materials also include 1.5%-2.5% of Amomum villosum extract; the preparation process of the Amomum villosum extract is as follows: using dried Amomum villosum fruit from Yangchun as raw material, supercritical CO2 extraction is adopted, with an extraction pressure of 20-25 MPa, an extraction temperature of 40-45℃, and an extraction time of 1.5-2.0 hours. After extraction, the volatile oil is removed by molecular distillation, with a volatile oil removal rate of ≥90% and a hesperidin retention rate of ≥95%.

4. The Dendrobium germ and ginseng powder solid beverage according to claim 1, characterized in that, The brown sugar is replaced with 4%-6% erythritol, and 5%-7% citric acid and 3%-5% povidone K30 are added to the raw materials to form an effervescent tablet. The performance parameters of the effervescent tablet are: tablet hardness 4-6 kg, disintegration time 25-35 seconds, and after dissolving in 100 mL of purified water at 25°C, the solution pH value is 5.5-6.5, and there are no visible insoluble substances.

5. The Dendrobium germ and ginseng powder solid beverage according to claim 1, characterized in that, The raw materials also include 8%-12% maltodextrin. After mixing the raw materials, they are made into slow-release granules and packaged in corn fiber triangular filter bags to form a tea bag dosage form. The preparation process of the slow-release granules is as follows: the mixed powder and maltodextrin are mixed at a mass ratio of 8-10:1, 20%-30% ethanol solution is added to make a soft mass, granulated by passing through a 14-16 mesh sieve, and dried at 50-55℃ until the moisture content is ≤5%. The performance parameters of the tea bag dosage form are: when soaked in 200mL of 85-95℃ hot water at 25℃ for 2.5-3.5 minutes, the extraction rate of effective ingredients (Dendrobium oligosaccharides, ginsenoside Rg1) is ≥85%.

6. A method for preparing a solid beverage of Dendrobium germ and ginseng powder as described in any one of claims 1-5, characterized in that, Includes the following steps: S1. Raw Material Pretreatment: Dendrobium officinale germ, ginseng, and Xinhui tangerine peel are processed separately using a low-temperature pulverization process at 5-15℃. After pulverization, the powder is passed through a 70-90 mesh sieve to obtain medicinal powder. If the raw material contains Amomum villosum extract, the Amomum villosum extract is mixed with the medicinal powder and stirred for 10-15 minutes until homogeneous. S2. Encapsulation Treatment: If component encapsulation is required, Amomum villosum extract is encapsulated separately using hydroxypropyl methylcellulose (HPMC) thermosensitive encapsulation material with a wall thickness of 1.2-1.8 μm. Sodium bicarbonate is mixed with Dendrobium officinale germ powder and ginseng powder, and encapsulated using ethyl cellulose (EC) pH... Response material encapsulation, capsule wall thickness 3.5-4.5μm; Dendrobium germ powder and ginseng powder are mixed, and sodium alginate-pH responsive material is used for encapsulation, capsule wall thickness 3.5-4.5μm; after encapsulation, it is passed through an 18-22 mesh sieve to remove agglomerated particles, and encapsulated particles are obtained; S3. Total mixing: The medicinal powder from step S1 or the encapsulated particles from step S2 are added to a three-dimensional mixer with brown sugar (or erythritol) and the remaining raw materials. The mixing speed is 15-20 r / min, and the total mixing time is 25-35 minutes. During the mixing process, it is passed through an 8-12 mesh sieve 1-2 times. The mixing uniformity is ensured to be ≥96% by online near-infrared spectroscopy monitoring, and mixed powder is obtained; S4. Molding and Packaging: For powder dosage form: the mixed powder is filled into bags at a specification of 1.5-2.5g / bag, packaged with an oxide release film, and the humidity inside the packaging is controlled at ≤12%-18%; For effervescent tablets: the mixed powder is mixed with povidone K30 and citric acid, granulated, passed through a 16-20 mesh sieve, and compressed into tablets under a pressure of 12-15MPa. After compression, the tablets are dried at 55-60℃ for 1-1.5 hours to remove residual moisture; For tea bag dosage form: the mixed powder is made into slow-release granules, packaged into corn fiber triangular filter bags at a specification of 2.0-2.5g / bag, and sealed with ultrasonic waves with a sealing strength ≥5N / 15mm.

7. The preparation method according to claim 6, characterized in that, In step S2, the raw materials for preparing the temperature-sensitive capsule material are HPMC and polyethylene glycol 400 mixed at a mass ratio of 9-10:1; the raw materials for preparing the pH-responsive capsule material are sodium alginate and chitosan mixed at a mass ratio of 8-9:1, and the encapsulation process adopts spray drying method with an inlet air temperature of 180-200℃ and an outlet air temperature of 80-90℃.

8. The preparation method according to claim 6, characterized in that, In step S3, the characteristic wavelengths of the online near-infrared spectroscopy monitoring are: 1200-1250nm for Dendrobium oligosaccharides and 1600-1650nm for ginsenoside Rg1. Spectral data are collected every 5 minutes, and the relative standard deviation (RSD) of the components is calculated. When the RSD ≤ 2.0%, it is determined that the mixture is uniform.

9. The preparation method according to claim 6, characterized in that, In step S4, the oxide separator is a PET / AL / PE composite membrane with a thickness of 80-100 μm, an oxygen permeability of ≤5 cm³ / (m²·24h·0.1 MPa), and a water vapor permeability of ≤2 g / (m²·24h).

10. The Dendrobium germ and ginseng powder solid beverage according to any one of claims 1-5, characterized in that, The solid beverage is beneficial for relieving stomach discomfort symptoms such as excessive stomach acid, stomach pain, and bloating. It can also increase the body's white blood cell level to enhance immunity and improve fatigue and weakness caused by insufficient qi and blood. The solid beverage is to be consumed as follows: the powder is mixed with 100-150mL of 40-60℃ warm water, the effervescent tablets are dissolved directly in 100-150mL of room temperature water, and the tea bag is steeped in 200mL of 85-95℃ hot water. The daily dosage is 1-2 sachets (tablets / packets), taken on an empty stomach or 1-2 hours after meals.