Preparation method of red ginseng product capable of preventing senile dementia

Abstract

The invention relates to the technical field of red ginseng preparation, in particular to a preparation method of a red ginseng product capable of preventing senile dementia, and the raw material formula comprises the following components: red ginseng, Chinese wolfberry fruit extract, walnut peptide, vitamin E, maltodextrin and magnesium stearate. The components and the proportion are as follows: the proportion of the red ginseng is 40 parts; the matching ratio of the fructus lycii extract is 15 parts; the ratio of the walnut peptide is 10 parts; the proportion of the vitamin E is 2 parts; the proportion of the maltodextrin is 31.5 parts; the proportion of the magnesium stearate is 1.5 parts; the processing technology comprises the following steps: step 1, pretreating raw materials; 2, strengthening extraction of effective components of red ginseng; step 3, mixing multiple components; step 4, granulating and forming; and step 5, packaging and inspecting. The invention aims to solve the problems that the crushing and grinding degree of red ginseng is insufficient, the compact tissue structure of red ginseng is difficult to fully break, the dissolution efficiency of subsequent effective components is influenced, and part of active components are oxidized and degraded.

Description

Technical Field

[0001] This invention relates to the field of red ginseng preparation technology, specifically to a method for preparing red ginseng products that can prevent Alzheimer's disease. Background Technology

[0002] The preparation of red ginseng products for preventing Alzheimer's disease uses red ginseng as the core raw material, and scientifically combines it with other food and medicine ingredients with nutritional and health benefits such as wolfberry extract and walnut peptides. The aim is to fully utilize the natural activity of red ginseng and other ingredients through the synergistic effect between the raw materials, so as to provide a safe and effective health product for preventing Alzheimer's disease.

[0003] Current methods for preparing red ginseng products for preventing Alzheimer's disease involve insufficient pulverization and grinding of the red ginseng, and an unreasonable drying process design. This makes it difficult to fully break down the dense structure of the red ginseng, which not only affects the dissolution efficiency of the subsequent active ingredients but may also cause some active ingredients to oxidize and degrade due to improper drying. At the same time, the screening process for excipients is relatively crude, which makes it easy to mix in lumpy materials or impurities, making it impossible to ensure the uniformity of raw materials and thus affecting the overall quality of the finished product. Summary of the Invention

[0004] The purpose of this invention is to provide a method for preparing red ginseng products that can prevent Alzheimer's disease, in order to solve the problems in the above-mentioned background technology where the degree of crushing and grinding of red ginseng is insufficient, the drying process design is not reasonable enough, and the dense tissue structure of red ginseng is difficult to break down, which not only affects the dissolution efficiency of the subsequent active ingredients, but may also cause some active ingredients to oxidize and degrade due to improper drying; at the same time, the screening process of excipients is relatively rough, which makes it easy to mix in lumpy materials or impurities, and cannot ensure the uniformity of raw materials, thus affecting the overall quality of the finished product.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a method for preparing red ginseng products that can prevent Alzheimer's disease, wherein the raw material formula includes the following components: red ginseng, wolfberry extract, walnut peptide, vitamin E, maltodextrin, and magnesium stearate;

[0006] The ingredients and proportions are as follows: red ginseng 40 parts; wolfberry extract 15 parts; walnut peptide 10 parts; vitamin E 2 parts; maltodextrin 31.5 parts; magnesium stearate 1.5 parts.

[0007] It also includes the following processing techniques:

[0008] Step 1: Raw material pretreatment;

[0009] Step Two: Enhanced Extraction of Active Ingredients from Red Ginseng;

[0010] Step 3: Mixing of multiple components;

[0011] Step 4: Granulation and molding;

[0012] Step 5: Packaging and Inspection.

[0013] Preferably, the raw material pretreatment includes: red ginseng treatment and auxiliary material treatment. In the red ginseng treatment, surface impurities, residual roots, and insect-infested parts are manually removed, and then the ginseng is placed in a universal pulverizer. The pulverizer is set to a speed of 2000 r / min and pulverized to 80 mesh before being discharged. The coarse powder is then fed into an ultrafine pulverizer, and the vacuum sealing system is activated to grind it to a particle size D. 50 ≤10μm, then the ultrafine red ginseng powder is evenly spread on the baking tray, placed in a vacuum drying oven, set at 60℃ and vacuum degree -0.09MPa, dried for 4 hours, and then cooled to room temperature. The moisture content is controlled at ≤8% under low temperature vacuum environment. For the excipient processing, wolfberry extract and walnut peptide are poured into a vibrating sieve, set at a vibration frequency of 1500 times / min and an amplitude of 5mm, and lumps and impurities are removed through a 100-mesh sieve to ensure uniform particle size of the excipients. Maltodextrin is poured into a sterile tray, placed in a hot air circulating oven, set at 50℃ and wind speed of 1.5m / s, dried for 2 hours, ventilated once every 30 minutes, and the moisture content is controlled at ≤1.5% to improve fluidity and prevent mixing and clumping. Vitamin E and magnesium stearate are stored at room temperature in a sealed container and protected from direct sunlight.

[0014] Preferably, the enhanced extraction of active ingredients from red ginseng includes adding 40 parts of ultrafine red ginseng powder to an ultrasonic extraction tank, adding deionized water filtered through a 0.22μm filter membrane at a material-to-liquid ratio of 1:10, setting the temperature to 60℃, ultrasonic power to 300W, and stirring speed to 50r / min, extracting for 1.5 hours, stirring for 5 minutes every 30 minutes. After extraction, the mixture is introduced into a plate and frame filter press via a feed pump, setting the pressure to 0.3MPa, separating the filtrate and filter residue through a 0.45μm filter membrane, and repeating the extraction of the filter residue once using the same process. The filtrates are then combined... To improve raw material utilization, the combined filtrate was poured into a rotary evaporator, with the temperature set at 70℃, vacuum at -0.08MPa, and rotation speed at 80r / min, and concentrated until the solid content was ≥50%. The low-temperature vacuum environment can prevent degradation of active ingredients and reduce subsequent energy consumption. Finally, the spray dryer was started, with the inlet air temperature set at 180℃, the outlet air temperature at 80℃, and the atomizer rotation speed at 15000r / min. After the temperature stabilized, the concentrated liquid was uniformly introduced, atomized, and quickly dried with hot air. The red ginseng extract powder was collected through a cyclone separator to retain the active ingredients to the greatest extent.

[0015] Preferably, in the multi-component mixing stage, red ginseng extract powder, 15 parts of wolfberry extract, 10 parts of walnut peptide, 2 parts of vitamin E, and 31.5 parts of maltodextrin are sequentially added to a double helix mixer. After closing the feed inlet, the speed is set to 60 r / min. After mixing for 20 minutes, a sample is taken for testing. If it passes the test, the side feed inlet is opened, and 1.5 parts of magnesium stearate are slowly added. Mixing continues for 5 minutes.

[0016] Preferably, the material mixed in the granulation and molding stages is poured into a rotary granulator. The screen aperture is set to 1.2 mm, the rotation speed to 40 r / min, and the pressure roller pressure to 1 MPa. The material is fed at a uniform speed and sprayed with an appropriate amount of deionized water. After extrusion, the material passes through the screen to form wet granules. The wet granules are evenly spread on the mesh belt of a belt dryer. The temperature is set to 55℃, the wind speed to 2.0 m / s, and the conveying speed to 1 m / min. After drying for 30 minutes, the moisture content is controlled to be ≤2% to ensure granule stability. The dry granules are then poured into a rotary tablet press. The pressure is set to 8 MPa, the rotation speed to 20 r / min, and the tablet weight to 0.5 g. The tablets are pressed into round tablets with a diameter of 8 mm. The hardness is sampled and tested every 10 minutes to ensure that the appearance and the user experience are consistent.

[0017] Preferably, after tableting in the packaging and inspection stage, the tablets are evenly spread on the metal detector conveyor belt at a set speed of 1 m / min. The belt is calibrated using a standard test block. Qualified tablets enter a fully automatic aluminum foil packaging machine, where they are loaded with aluminum foil composite film at a set speed of 60 blister packs / h, a heat-sealing temperature of 150℃, and a cooling time of 1 second. The tablets are packaged at a specification of 12 tablets per blister pack, with the production batch number and shelf life printed simultaneously. The shelf life is extended to 18 months through independent sealing. Finally, finished product inspection is performed: three bags are randomly selected from each batch, 5g of tablets are ground, and 45mL of sterile physiological saline is added. 1mL of the suspension is injected into a total bacterial count detector, with a set temperature of 37℃ and a time of 24 hours. The total bacterial count, coliform bacteria, and pathogenic bacteria are tested. Qualified tablets are then stored in the warehouse.

[0018] Compared with the prior art, the beneficial effects of the present invention are:

[0019] 1. In terms of efficacy, this invention scientifically combines red ginseng with wolfberry extract, walnut peptides, and other food-grade medicinal ingredients. The synergistic effect of these ingredients fully leverages the active components in red ginseng, while also incorporating the nutritional advantages of other components. This provides a high-quality natural product option for preventing Alzheimer's disease. In terms of production, the refined raw material pretreatment and enhanced extraction process maximizes the retention of active ingredients and nutrients in the raw materials, improves the comprehensive utilization rate of raw materials, and avoids the loss of effective components. Subsequent processes such as mixing, granulation, and tableting are standardized and orderly, coupled with precise equipment operation, ensuring that the finished product has uniform composition, regular shape, and stable quality, effectively avoiding batch-to-batch quality differences.

[0020] 2. Through a rigorous inspection process and sealed packaging technology, this invention not only ensures the food safety of the product but also extends its shelf life and facilitates storage and portability. The overall process is adapted to the needs of industrial production, is standardized and efficient, helps reduce production losses and costs, enables large-scale supply of the product, and takes into account both the product's efficacy and market application prospects. Attached Figure Description

[0021] Figure 1 This is a schematic diagram of the process of the present invention. Detailed Implementation

[0022] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

[0023] This invention provides a method for preparing red ginseng products that can prevent Alzheimer's disease. The raw material formula includes the following components: red ginseng, wolfberry extract, walnut peptide, vitamin E, maltodextrin, and magnesium stearate.

[0024] The ingredients and proportions are as follows: red ginseng 40 parts; wolfberry extract 15 parts; walnut peptide 10 parts; vitamin E 2 parts; maltodextrin 31.5 parts; magnesium stearate 1.5 parts.

[0025] It also includes the following processing techniques:

[0026] Step 1: Raw material pretreatment;

[0027] Step Two: Enhanced Extraction of Active Ingredients from Red Ginseng;

[0028] Step 3: Mixing of multiple components;

[0029] Step 4: Granulation and molding;

[0030] Step 5: Packaging and Inspection;

[0031] Specifically, red ginseng: 40 portions, must be selected from 6-year-old Korean red ginseng, meeting the GB / T22538 "Ginseng" standard, with a total saponin (Rg1+Rb1+Re) content ≥3.0%, moisture ≤12%, heavy metal Pb ≤0.5mg / kg, and free from mold, insect infestation and pesticide residues;

[0032] Goji berry extract: 15 parts, made from Ningxia Zhongning goji berries, with goji berry polysaccharide content ≥50%, particle size ≥100 mesh, moisture ≤8.0%, total flavonoids ≥1.2%, and no clumping impurities;

[0033] Walnut peptides: 10 parts, molecular weight ≤3000Da, protein content ≥85%, amino acid nitrogen ≥3.0g / 100g, no solvent residue, no bitter taste;

[0034] Vitamin E: 2 parts, extracted from natural soybean oil, conforming to GB14756 standard, α-tocopherol content ≥96%, moisture ≤0.5%;

[0035] Maltodextrin: 31.5 parts, conforming to GB / T20884 standard, DE value 18-20, water solubility ≥98%, 80 mesh passing rate ≥95%, moisture ≤6.0%;

[0036] Magnesium stearate: 1.5 parts, food grade, conforming to GB1886.91 standard, magnesium content 9.5%-11.5%, moisture ≤5.0%.

[0037] Raw material pretreatment includes: red ginseng processing and auxiliary material processing. For red ginseng processing, surface impurities, residual roots, and insect-infested parts are manually removed. The ginseng is then placed in a universal pulverizer, set to a speed of 2000 rpm, and pulverized to 80 mesh before being discharged. The coarse powder is then fed into an ultrafine pulverizer, and the vacuum sealing system is activated to grind it to a particle size D. 50 ≤10μm, then spread the ultrafine red ginseng powder evenly on the baking tray, put it into the vacuum drying oven, set the temperature to 60℃ and the vacuum degree to -0.09MPa, dry for 4 hours and then cool to room temperature, control the moisture content to ≤8% under low temperature vacuum environment; for excipient processing, pour the wolfberry extract and walnut peptide into the vibrating sieve, set the vibration frequency to 1500 times / min and the amplitude to 5mm, and remove lumps and impurities through a 100-mesh sieve to ensure uniform particle size of excipients, pour the maltodextrin into a sterile tray, put it into a hot air circulating oven, set the temperature to 50℃ and the wind speed to 1.5m / s, dry for 2 hours, ventilate once every 30 minutes, control the moisture content to ≤1.5%, improve fluidity to prevent mixing and clumping, and store vitamin E and magnesium stearate in a sealed container at room temperature, avoiding direct sunlight;

[0038] Specifically, red ginseng processing: Pre-treatment process: Manual removal of surface impurities, residual roots, and insect-infested parts; then, using a universal pulverizer (model WF-130 pulverizer, speed 2000r / min, 80 mesh) to feed the ginseng into an ultrafine pulverizer (model WFM-100) for grinding (vacuum sealing system, particle size D). 50 ≤10μm particles are introduced into a vacuum drying oven (model DZF-6050) for drying (60℃, vacuum degree -0.09MPa, 4h, moisture content ≤8%), followed by cooling to room temperature; Equipment requirements and functions: Universal pulverizer (WF-130): inner liner 304 stainless steel, speed adjustable 1000-3000r / min, function is to break down the dense structure of red ginseng, reduce the difficulty of subsequent grinding, and improve processing efficiency; Ultrafine pulverizer (WFM-100): grinding chamber made of zirconium corundum, vacuum sealed design, function is to increase the specific surface area of ​​red ginseng powder, improve the dissolution efficiency of effective components during subsequent extraction, and facilitate human absorption; Vacuum drying oven (DZF-6050): temperature control accuracy ±1℃, vacuum degree up to -0.095MPa, function is to remove moisture in a low-temperature vacuum environment, avoid saponin oxidation and decomposition, and inhibit microbial growth;

[0039] Excipient Processing: Pre-treatment Process: Goji Berry Extract and Walnut Peptide: Screened using a vibrating sieve (model ZS-515) (vibration frequency 1500 times / min, amplitude 5mm, 100-mesh sieve) to remove lumps and impurities; Maltodextrin: Placed in a sterile tray (layer thickness ≤2cm) and introduced into a hot air circulating oven (model CT-C-200) for drying (50℃, wind speed 1.5m / s, 2h, ventilated once every 30min, moisture content ≤1.5%); Vitamin E and Magnesium Stearate: Stored at room temperature in a sealed container, avoiding direct sunlight; Equipment Requirements and Functions: Vibrating Sieve (ZS-515): Stainless steel sieve with aperture accuracy ±0.01mm, its function is to ensure uniform particle size of excipients and prevent lumps from affecting subsequent mixing effects; Hot Air Circulating Oven (CT-C-200): Hot air uniformity ±5%, odorless inner chamber, its function is to reduce the moisture content of maltodextrin, improve fluidity, and prevent moisture absorption and lumps during mixing.

[0040] Enhanced extraction of active ingredients from red ginseng involves adding 40 parts of ultrafine red ginseng powder to an ultrasonic extraction tank, adding deionized water filtered through a 0.22μm membrane at a material-to-liquid ratio of 1:10, setting the temperature to 60℃, ultrasonic power to 300W, and stirring speed to 50r / min, and extracting for 1.5 hours with stirring for 5 minutes every 30 minutes. After extraction, the mixture is fed into a plate and frame filter press using a feed pump, with a pressure set to 0.3MPa. The filtrate and residue are separated through a 0.45μm membrane. The residue is extracted once more using the same process, and the filtrates are combined to improve the original content. To improve material utilization, the combined filtrate was poured into a rotary evaporator, with the temperature set at 70℃, vacuum at -0.08MPa, and rotation speed at 80r / min, and concentrated until the solid content was ≥50%. The low-temperature vacuum environment can prevent the degradation of active ingredients and reduce subsequent energy consumption. Finally, the spray dryer was started, with the inlet air temperature set at 180℃, the outlet air temperature at 80℃, and the atomizer rotation speed at 15000r / min. After the temperature stabilized, the concentrated liquid was introduced at a uniform speed, atomized, and quickly dried with hot air. The red ginseng extract powder was collected through a cyclone separator to retain the active ingredients to the greatest extent.

[0041] Specifically, the extraction process is as follows: 40 parts of ultrafine red ginseng powder and deionized water are added to the ultrasonic extraction tank (model HS-50) and filtered through a 0.22μm filter membrane at a material-to-liquid ratio of 1:10. The parameters are set (60℃, ultrasonic power 300W, stirring speed 50r / min, extraction time 1.5h, stirring for 5min every 30min). The mixture is then filtered using a plate and frame filter press (model XAY-100) (pressure 0.3MPa, 0.45μm filter membrane). The filter residue is extracted once more. The filtrates are combined and concentrated using a rotary evaporator (model RE-52AA) (70℃, vacuum degree -0.08MPa, rotation speed 80r / min, solids ≥50%). The mixture is then dried using a spray dryer (model LPG-5) (inlet air 180℃, outlet air 80℃, atomizer speed 15000r / min). The red ginseng extract powder is collected using a cyclone separator.

[0042] Equipment requirements and functions:

[0043] Ultrasonic Extraction Tank (HS-50): 316L stainless steel tank, ultrasonic frequency 40kHz, equipped with anchor-type stirring paddle. Its function is to use the ultrasonic cavitation effect to break down the cell wall of red ginseng, accelerate the dissolution of saponins, shorten the extraction time by 60% and increase the retention rate of effective ingredients by 20% compared with traditional extraction.

[0044] Plate and frame filter press (XAY-100): Food-grade polypropylene filter membrane, adjustable pressure 0.1-0.6MPa, its function is to quickly separate filtrate and filter residue to obtain clear filtrate, and secondary extraction to improve raw material utilization;

[0045] Rotary evaporator (RE-52AA): High borosilicate glass evaporation flask, condensation recovery device, its function is low temperature vacuum concentration to remove a large amount of water, reduce subsequent drying energy consumption, and avoid degradation of effective ingredients;

[0046] Spray dryer (LPG-5): The atomizer speed is adjustable from 10,000 to 20,000 r / min, and the powder collection rate is ≥90%. Its function is to quickly atomize and dry the concentrated liquid to form a dry powder with good flowability, and retain the active ingredients to the maximum extent.

[0047] In the multi-component mixing stage, red ginseng extract powder, 15 parts of wolfberry extract, 10 parts of walnut peptide, 2 parts of vitamin E, and 31.5 parts of maltodextrin were added to the double helix mixer in sequence. After closing the feed inlet, the speed was set to 60 r / min. After mixing for 20 minutes, a sample was taken for testing. After passing the test, the side feed inlet was opened, and 1.5 parts of magnesium stearate were slowly added. Mixing continued for 5 minutes.

[0048] Specifically, the hybrid process:

[0049] Add red ginseng extract powder, 15 parts wolfberry extract, 10 parts walnut peptide, 2 parts vitamin E, and 31.5 parts maltodextrin to a double helix mixer (model WHS-500) in sequence. Close the feed inlet, set the speed to 60 r / min, mix for 20 min, and take samples for testing (saponin content deviation ≤5%, qualified). Open the side feed port, add 1.5 parts magnesium stearate, continue mixing for 5 min, and then discharge.

[0050] Equipment Requirements and Functions: Double Helix Mixer (WHS-500): 316L stainless steel mixing chamber, double helix blades, mixing uniformity variation coefficient ≤5%. Its function is to achieve uniform mixing of multiple components through shearing and convection, avoiding uneven concentration of local components; at the same time, it allows magnesium stearate to adhere evenly to the surface of the material, reducing the phenomenon of sticking to the wall during subsequent granulation and tableting.

[0051] After mixing in the granulation and forming stages, the material is poured into a rotary granulator. The screen aperture is set to 1.2 mm, the rotation speed to 40 r / min, and the pressure roller pressure to 1 MPa. The material is fed at a uniform speed and sprayed with an appropriate amount of deionized water. After extrusion, the material passes through the screen to form wet granules. The wet granules are then evenly spread on the belt of a belt dryer. The temperature is set to 55℃, the wind speed to 2.0 m / s, and the conveying speed to 1 m / min. After drying for 30 minutes, the moisture content is controlled to be ≤2% to ensure granule stability. The dry granules are then poured into a rotary tablet press. The pressure is set to 8 MPa, the rotation speed to 20 r / min, and the tablet weight to 0.5 g. The tablets are pressed into round tablets with a diameter of 8 mm. The hardness is sampled and tested every 10 minutes to ensure that the appearance and the user experience are consistent.

[0052] Specifically, the granulation and tableting process:

[0053] The mixed materials were granulated using a rotary granulator (model XL-30) (1.2mm screen aperture, 40r / min rotation speed, 1MPa pressure roller, and deionized water spraying for bonding), dried in a wet granule belt dryer (model DWT-1.2×8) (55℃, 2.0m / s air velocity, 1m / min conveying speed, 30min, moisture content ≤2%), and compressed into tablets using a dry granule rotary tablet press (model ZP-17) (8MPa pressure, 20r / min rotation speed, 0.5g tablet weight, 8mm diameter). Hardness was tested every 10min (acceptable range 5-7kgf).

[0054] Equipment Requirements and Functions: Rotary Granulator (XL-30): 304 stainless steel granulation chamber, replaceable screen aperture. Its function is to convert mixed powder into uniform granules, improve material flowability and compressibility, and prevent tablet cracking and fragmentation; Belt Dryer (DWT-1.2×8): 1.2m wide belt, temperature control accuracy ±2℃. Its function is to remove moisture from wet granules, improve granule stability, and ensure that tablet disintegration time meets the requirements; Rotary Tableting Machine (ZP-17): Alloy steel pressure rollers, weight control accuracy ±0.01g. Its function is to accurately control tablet weight and hardness, ensuring that tablets are of regular shape and provide a consistent user experience.

[0055] After tableting in the packaging and inspection stage, the tablets are evenly spread on the metal detector conveyor belt at a speed of 1 m / min. The belt is calibrated with a standard test block. Qualified tablets enter the fully automatic aluminum foil packaging machine, where they are loaded with aluminum foil composite film at a speed of 60 blister packs / h, a heat sealing temperature of 150℃, and a cooling time of 1 second. They are packaged at a specification of 12 tablets per blister pack, with the production batch number and shelf life printed simultaneously. The shelf life is extended to 18 months through independent sealing. Finally, the finished product is inspected: 3 bags are randomly selected from each batch, 5g of tablets are ground and added to 45mL of sterile physiological saline, and 1mL of suspension is injected into the total bacterial count detector. The temperature is set at 37℃ and the time is 24h to detect the total bacterial count, coliform bacteria, and pathogenic bacteria. Qualified tablets are then put into storage.

[0056] Specifically, the packaging and inspection process:

[0057] Tablet metal detector (model MD-3000) detection (transmission speed 1m / min, standard test block Fe0.5mm, SUS1.0mm calibration, removing metal impurities), fully automatic aluminum foil packaging machine (model DPP-140) packaging (speed 60 plates / h, heat sealing temperature 150℃, cooling time 1s, 12 tablets per plate, printing production information), finished product inspection, 3 bags of each batch are sampled, 5g tablets are mixed with 45mL of sterile physiological saline, 1mL of suspension is taken, and total bacterial count is tested by a colony count detector (model JC-200) (37℃, 24h). The qualified standard is: total bacterial count ≤100CFU / g, coliform bacteria ≤30CFU / 100g, pathogenic bacteria not detected, and then put into storage (warehouse temperature ≤25℃, humidity ≤65%).

[0058] Equipment Requirements and Functions: Metal Detector (MD-3000): Detection accuracy Fe≥0.5mm, SUS≥1.0mm, equipped with audible and visual alarms and an automatic rejection device. Its function is to remove metal impurities (such as equipment wear particles) mixed in during processing, ensuring food safety; Fully Automatic Aluminum Foil Packaging Machine (DPP-140): Heat sealing temperature accuracy ±5℃, clear and abrasion-resistant coding. Its function is to independently seal packaging, isolating oxygen and moisture, extending shelf life to 18 months, and facilitating portability and traceability; Total Bacterial Count Analyzer (JC-200): Detection range 10-10... 6 The CFU / g test, with a testing time of ≤24h, is used to control the microbial safety of finished products and avoid the risk of food consumption due to excessive microbial levels.

[0059] Work Process: First, the raw materials undergo meticulous pretreatment. After manually removing impurities and blemishes from the surface of the red ginseng, its morphology and moisture content are optimized through crushing, fine grinding, and low-temperature drying. Simultaneously, excipients such as goji berry extract and walnut peptides are screened and purified, and maltodextrin is dried to ensure all raw materials meet the requirements for subsequent processing. Vitamin E and magnesium stearate are sealed and stored according to standard conditions. Next, the extraction of active ingredients from the red ginseng begins. The pretreated red ginseng powder is mixed with purified deionized water, and the active ingredients are fully dissolved using ultrasonic-assisted extraction technology, followed by filtration. After separation, the filter residue is repeatedly extracted to improve the utilization rate of raw materials. The combined extract is concentrated and dried to form red ginseng extract powder, which is easy to process later. Then, the red ginseng extract and various excipients are put into the mixing equipment in sequence and stirred thoroughly to achieve uniform mixing. Then, through granulation, drying and tableting processes, the mixture is transformed into tablets with regular shape and qualified hardness. Finally, the tablets are tested for metal impurities and individually sealed and packaged. Product traceability information is printed at the same time. After passing the microbial index test, they are stored in the warehouse according to the standard conditions to ensure the safety, stability and shelf life of the finished product.

[0060] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A preparation method of red ginseng product capable of preventing senile dementia, the raw material formula comprising the following ingredients: red ginseng, wolfberry extract, walnut peptide, vitamin E, malt dextrin, magnesium stearate; the ingredients and the ratio are as follows: the ratio of the red ginseng is 40 parts; the ratio of the wolfberry extract is 15 parts; the ratio of the walnut peptide is 10 parts; the ratio of the vitamin E is 2 parts; the ratio of the malt dextrin is 31.5 parts; and the ratio of the magnesium stearate is 1.5 parts; and further comprising the following processing technology: Step 1: raw material pretreatment; Step 2: red ginseng active ingredient extraction; Step 3: multi-component mixing; Step 4: granulation and molding; Step 5: packaging and inspection.

2. The method for preparing a red ginseng product that can prevent Alzheimer's disease according to claim 1, characterized in that, The raw material pretreatment includes: red ginseng treatment and auxiliary material treatment, after the artificial removal of surface impurities, residual roots and insect damaged parts, the red ginseng is put into a universal crusher, the rotation speed is set to 2000r / min, and the red ginseng is crushed to 80 mesh, then the coarse powder is put into a super micro grinder, the vacuum sealing system is started, and the red ginseng is ground to a particle size D 50 ≤10μm, then the super micro red ginseng powder is evenly laid on a baking tray, and is put into a vacuum drying box, the temperature is set to 60℃, the vacuum degree is set to-0.09MPa, the red ginseng is dried for 4h, and then cooled to room temperature, the moisture content is controlled to be less than or equal to 8% under the low-temperature vacuum environment; the auxiliary material treatment is that the wolfberry extract and walnut peptide are respectively poured into a vibrating sieve machine, the vibration frequency is set to 1500 times / min, the amplitude is set to 5mm, the caking and impurities are removed through a 100 mesh screen, the uniform particle size of the auxiliary material is ensured, the malt dextrin is poured into a sterile tray, and is put into a hot air circulation oven, the temperature is set to 50℃, the air speed is set to 1.5m / s, the malt dextrin is dried for 2h, the ventilation is performed once every 30min, the moisture content is controlled to be less than or equal to 1.5%, the flowability is improved to prevent caking, the vitamin E and magnesium stearate are stored at room temperature in a sealed manner, and direct sunlight is avoided.

3. The method for preparing a red ginseng product that can prevent Alzheimer's disease according to claim 1, characterized in that, The red ginseng active ingredient extraction comprises adding 40 parts of ultra-fine red ginseng powder into an ultrasonic extraction tank, adding deionized water filtered through a 0.22 μm filter according to a material-liquid ratio of 1:10, setting a temperature of 60°C, an ultrasonic power of 300 W, and a stirring speed of 50 r / min, and extracting for 1.5 h with 5 min of stirring every 30 min; after the extraction is completed, the mixture is introduced into a plate-and-frame filter press through a feed pump, a pressure of 0.3 MPa is set, and the filtrate and the filter residue are separated through a 0.45 μm filter; the filter residue is extracted again according to the same process once, the filtrates are combined to improve the utilization rate of the raw material, the combined filtrate is poured into a rotary evaporator, a temperature of 70°C, a vacuum degree of -0.08 MPa, and a rotating speed of 80 r / min are set, and the filtrate is concentrated to a solid content of ≥50%; a low-temperature vacuum environment can avoid degradation of the active ingredients and reduce subsequent energy consumption; finally, a spray dryer is started, the inlet air temperature is set to 180°C, the outlet air temperature is set to 80°C, the rotating speed of the atomizer is set to 15000 r / min, the concentrated liquid is introduced at a uniform speed after the temperature is stabilized, and the atomized liquid is quickly dried with hot air; the red ginseng extract dry powder is collected through a cyclone separator, and the active ingredients are retained to the maximum extent.

4. The method for preparing a red ginseng product that can prevent Alzheimer's disease according to claim 1, characterized in that, In the multi-component mixing stage, the red ginseng extract dry powder, 15 parts of wolfberry extract, 10 parts of walnut peptide, 2 parts of vitamin E, and 31.5 parts of malt dextrin are sequentially added into a double-screw mixer, the rotating speed is set to 60 r / min after the feeding port is closed, the mixture is mixed for 20 min and sampled for detection, 1.5 parts of magnesium stearate is slowly added through the side feeding port after the mixture is qualified, and the mixture is continuously mixed for 5 min.

5. A method for preparing a red ginseng product that can prevent Alzheimer's disease according to claim 1, characterized in that, In the granulation and molding stage, the mixed material is poured into a rotary granulator, the screen mesh aperture is set to 1.2 mm, the rotating speed is set to 40 r / min, the pressure of the pressure roller is set to 1 MPa, the material is fed at a uniform speed and sprayed with an appropriate amount of deionized water, the wet granules are formed through the screen mesh after being extruded, the wet granules are evenly laid on the belt dryer net belt, the temperature is set to 55°C, the air speed is set to 2.0 m / s, and the transmission speed is set to 1 m / min, the moisture content of the dry granules is controlled to ≤2% after being dried for 30 min to ensure the stability of the granules, the dry granules are poured into a rotary tablet press, the pressure is set to 8 MPa, the rotating speed is set to 20 r / min, and the tablet weight is set to 0.5 g, and the dry granules are pressed into circular tablets with a diameter of 8 mm; the hardness of the tablets is sampled and detected every 10 min to ensure the consistency of the appearance and the taking experience.

6. The method for preparing a red ginseng product that can prevent Alzheimer's disease according to claim 1, characterized in that, After the tabletting of the packaging and inspection stage, the tablets are evenly laid on the metal detector transmission belt, the speed is set to 1 m / min, and the standard test block is calibrated. The qualified tablets enter the full-automatic aluminum foil packaging machine, are packed in aluminum foil composite film, the speed is set to 60 plates / h, the heat sealing temperature is 150 DEG C, the cooling time is 1 s, the tablets are packed according to the specification of 12 tablets per plate, the production batch number and the shelf life are synchronously sprayed and printed, the shelf life is extended to 18 months through independent sealing, and finally the finished product inspection is carried out: 3 bags are taken from each batch, 5 g of tablets are ground and then added into 45 mL of sterile normal saline, 1 mL of the suspension is injected into a total number of colonies detector, the temperature is set to 37 DEG C, the time is 24 h, the total number of colonies, coliform bacteria and pathogenic bacteria are detected, and the qualified products are stored in the warehouse.

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