Hair removal composition and application thereof

Abstract

The invention relates to the technical field of pet health care, in particular to a hair removal composition and application thereof. The keratinase and the enterococcus faecium in the hair removal composition have a compound synergistic effect, and after the keratinase softens hair, the keratinase is matched with the enterococcus faecium to effectively promote hair removal and improve the hair removal effect, so that the hair removal composition disclosed by the embodiment of the invention has a good effect of promoting hair removal in animal bodies such as cats and the like; and the occurrence risk of related diseases such as hair bulb is reduced. Besides, through the synergistic effect of keratinase and enterococcus faecium in the hair removal composition, the same hair removal effect can be achieved on the premise that the use dosage of the hair removal composition is reduced, and meanwhile potential side effects and cost are reduced.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of pet health care, and particularly relates to a hair expelling composition and application thereof. BACKGROUND

[0002] Cats have the habit of licking fur for reasons such as cleaning themselves, hunting instinct, regulating body temperature, etc. to relieve itching caused by parasites or bacteria, hide themselves by licking off the odor on their bodies, and avoid being discovered by predators and prey. In the process of licking fur, cats inevitably swallow the floating fur on their bodies. According to statistics, an adult cat may swallow 10-20 grams of fur per year (about 1 / 3 of the total amount of fur), which will gradually accumulate in the stomach with food and form a hair ball. When the hair ball reaches a certain size, it will develop into a hairball disease. Cats with hairball disease will have symptoms such as constipation, dry stool, vomiting, and vomiting. In addition, there are many complications associated with cat hairball disease, such as intestinal obstruction, chronic inflammation, and malnutrition.

[0003] In order to alleviate and prevent cat hairball disease, pet food with hair-removing and hair-expelling effects is usually fed to cats to promote the expulsion of cat fur in the body. The common hair-removing food on the market mainly includes hair-removing cream and hair-removing tablets. However, the existing hair-removing cream and other hair-removing products usually contain mineral oil, artificial preservatives (such as BHA / BHT) or fragrances. Long-term use of hair-removing cream containing mineral oil may cause some irritation to the cat's intestinal tract, which may cause the cat to have diarrhea and intestinal function disorder. Hair-removing tablets and other hair-removing products usually contain malt dextrin, starch and sodium carboxymethyl cellulose for tablet molding, and lactose-containing cow (sheep) milk powder for improving the palatability of cats. Since cats lack sufficient amylase to efficiently break down starch, excessive starch may cause abdominal distension, soft stool or chronic intestinal inflammation. Moreover, as carnivorous animals, cats have weak ability to digest carbohydrates, and excessive malt dextrin may cause digestive problems such as diarrhea. Therefore, hair-removing tablets containing malt dextrin and starch are not suitable for cats with special physiological needs or metabolic characteristics such as diabetes, obesity or gastrointestinal sensitivity.

[0004] In the prior art, keratinase and probiotics are also used to promote the expulsion of cat fur in the body to alleviate the health problems caused by hair accumulation. The use of keratinase and probiotics to promote hair expulsion is relatively mild and has less irritation to the cat's intestinal tract. However, the existing keratinase and probiotics have poor hair-expelling effect. SUMMARY

[0005] The present application aims to provide a hair-expelling composition to solve the technical problem of limited hair-expelling effect of keratinase and probiotics in the prior art.

[0006] To achieve the above application purposes, the technical solutions adopted by the present application are as follows: In a first aspect, the embodiments of the present application provide a hair shedding composition. The hair shedding composition of the embodiments of the present application comprises a keratinase and Enterococcus faecium.

[0007] In the hair shedding composition of the embodiments of the present application, the keratinase and the Enterococcus faecium have a synergistic effect. After the keratinase softens the hair, the Enterococcus faecium can effectively promote the shedding of the hair, improve the hair shedding effect, so that the hair shedding composition of the embodiments of the present application has a good effect on promoting the shedding of the hair in animals such as cats, and reduces the risk of occurrence of related diseases such as hairball syndrome. In addition, the synergistic effect of the keratinase and the Enterococcus faecium in the hair shedding composition of the embodiments of the present application can achieve the same hair shedding effect while reducing the dosage and the potential side effects and cost.

[0008] In a second aspect, the embodiments of the present application provide an application of the hair shedding composition in the above in a pet hair shedding product.

[0009] Based on the good hair shedding effect and less side effects of the hair shedding composition in the above, the hair shedding composition can effectively improve the hair shedding effect of the hair shedding product and reduce the side effects of the hair shedding product when the hair shedding composition is used in the hair shedding product.

[0010] In some embodiments, the hair shedding product can be a depilation paste, a depilation tablet, etc., and the specific type is not limited.

[0011] In a third aspect, the embodiments of the present application provide a hair shedding pet food. The hair shedding pet food of the embodiments of the present application comprises the following components in parts by weight: Barley seedling powder 0.5-2 parts; Wheat seedling powder 0.1-0.5 parts; Plantago ovata husk powder 2-10 parts; Fructo-oligosaccharide 1.5-3 parts; Yucca 0.1-0.5 parts; Hair shedding composition 0.2-1.6 parts; The hair shedding composition is the hair shedding composition described above.

[0012] In the hair shedding pet food of the embodiments of the present application, the hair shedding composition has a good hair shedding effect, the plantago ovata husk powder contains a large amount of soluble fiber, which can be absorbed to form a gel to lubricate and wrap the hair and soften the feces; the barley seedling powder and the wheat seedling powder are rich in insoluble fiber, which can stimulate the intestinal tract and simulate the herbivorous behavior to promote physical hair shedding. The yucca and the fructo-oligosaccharide can regulate the flora, promote digestion and absorption, and improve the intestinal environment, which can directly enhance the intestinal function and indirectly help hair shedding. The hair shedding pet food of the embodiments of the present application further improves the hair shedding effect by compounding the hair shedding composition with the barley seedling powder, the wheat seedling powder, the plantago ovata husk powder, the fructo-oligosaccharide, and the yucca, which can effectively promote the shedding of the hair in cats and improve the intestinal health of the cats and relieve discomfort.

[0013] In a fourth aspect, the embodiments of the present application provide a preparation method of the dehairing pet food. The preparation method of the dehairing pet food comprises the following steps: The barley seedling powder, the wheat seedling powder, the plantago ovata seed shell powder, the yucca, the fructo-oligosaccharide and the dehairing composition are mixed to obtain the dehairing pet food.

[0014] The preparation method of the dehairing pet food mixes the barley seedling powder, the wheat seedling powder, the plantago ovata seed shell powder, the yucca, the fructo-oligosaccharide and the dehairing composition to obtain the dehairing pet food with good dehairing effect. The preparation method of the dehairing pet food has few operation steps and the process parameters are easy to control, and is suitable for commercial production. BRIEF DESCRIPTION OF DRAWINGS

[0015] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following will briefly introduce the drawings needed to be used in the embodiments or prior art description. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative labor.

[0016] Figure 1 The last day of the dehairing (dehairing) efficacy test for cats fed the dehairing tablet of Example B1, Comparative Example B1 and Comparative Example B2, and the fecal hair map of the domestic cat. DETAILED DESCRIPTION

[0017] In order to make the technical problems, technical solutions and beneficial effects of the present application more clearly understood, the following will further describe the present application in combination with embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and not to limit the present application.

[0018] In the present application, the term "and / or" describes the association relationship of the associated objects, which means that there can be three kinds of relationships, for example, A and / or B, which can mean that A exists alone, A and B exist together, and B exists alone. Wherein A and B can be singular or plural. The character " / " generally represents that the front and rear associated objects are in an "or" relationship.

[0019] In this application, "at least one" means one or more, and "multiple" means two or more. "At least one of the following" or similar expressions means any combination of these items, including a single item or any combination of multiple items. For example, "at least one of a, b, or c", or "at least one of a, b, and c", can mean a, b, c, a~b (i.e. a and b), a~c, b~c, or a~b~c, where a, b, and c can be single or multiple.

[0020] It should be understood that the size of the sequence number of the above-mentioned processes in various embodiments of the present application does not mean the order of execution, and part or all of the steps can be executed in parallel or in sequence, and the execution order of the processes should be determined according to their functions and internal logic, and should not constitute any limitation on the implementation process of the embodiments of the present application.

[0021] The terms used in the embodiments of the present application are only for the purpose of describing specific embodiments, and are not intended to limit the present application. The singular forms "a" and "the" used in the embodiments of the present application and the appended claims are also intended to include the plural forms, unless the context clearly indicates otherwise.

[0022] The weight of the related components mentioned in the specification of the embodiments of the present application can not only refer to the specific content of each component, but also represent the weight ratio relationship between each component, therefore, as long as the content of the related components in the specification of the embodiments of the present application is enlarged or reduced in proportion, it is within the scope disclosed in the specification of the embodiments of the present application. Specifically, the mass in the specification of the embodiments of the present application can be µg, mg, g, kg, etc. mass units well known in the chemical industry.

[0023] The terms "first", "second" are only for the purpose of description, used to distinguish objects such as substances from each other, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of indicated technical features. For example, without departing from the scope of the embodiments of the present application, the first XX can also be called the second XX, and similarly, the second XX can also be called the first XX. Therefore, the features limited by "first" and "second" can explicitly or implicitly include one or more of the features.

[0024] To solve the technical problem that the keratinase and probiotics have limited hair removal effect in the prior art, the present application provides the following technical solutions.

[0025] In a first aspect, the embodiments of the present application provide a hair removal composition. The hair removal composition of the present embodiment comprises keratinase and Enterococcus faecium.

[0026] The keratinase in the hair removal composition has the ability to decompose hair keratin, can soften or preliminarily degrade the complex structure in the hair, thereby softening the hair ball and promoting the hair ball to pass through the intestinal tract. Enterococcus faecium as a probiotic can regulate the balance of intestinal flora, improve the intestinal microecological environment, enhance intestinal peristalsis, and promote the excretion of hair. The hair removal composition of the present application can effectively promote the excretion of hair and improve the hair removal effect through the synergistic effect of keratinase and Enterococcus faecium. The hair removal composition of the present application has good effect on promoting the excretion of hair in animals such as cats, and can more effectively alleviate the problem of accumulation of hair in the body caused by licking hair in animals such as cats, and reduce the risk of related diseases such as trichobezoar. In addition, the synergistic effect of keratinase and Enterococcus faecium in the hair removal composition of the present application can achieve the same hair removal effect while reducing the potential side effects and cost under the premise of reducing the dosage of the hair removal composition.

[0027] The hair removal composition of the present application can promote the excretion of hair ball in animals such as cats which are prone to accumulate hair ball in the body. The hair removal effect of the hair removal composition of the present application is described in the present application by taking cats as an example.

[0028] In some embodiments, the keratinase can be a keratinase with an enzyme activity of ≥100,000 u / g.

[0029] In some embodiments, the Enterococcus faecium can be Enterococcus faecium JYEF-355 with a preservation number of CGMCC No. 27222, and the viable count of the Enterococcus faecium can be ≥10 10 CFU / g.

[0030] By controlling the enzyme activity of the keratinase and compounding the keratinase with specific Enterococcus faecium, the synergistic effect of the keratinase and the Enterococcus faecium is further improved, and the hair removal effect of the hair removal composition of the present application is further improved.

[0031] In some embodiments, the mass ratio of the keratinase and the Enterococcus faecium can be 1:8-8:1, optionally 2:6-6:2, 3:2-3:5, 3:6-6:2, and in exemplary examples, it can be 1:8, 1:7, 1:6, 1:5, 1:4, 1:3, 1:2, 1:1, 2:7, 2:5, 2:3, 3:1, 3:2, 3:4, 3:5, 3:7, 4:1, 4:2, 4:3, 5:1, 6:1, 7:1, 8:1, and the like typical but non-limiting ratios, or any ratio between any two ratio values. Controlling the mass ratio of the keratinase and the Enterococcus faecium in this range can further promote the synergistic effect of the keratinase and the Enterococcus faecium, thereby further improving the hair removal effect of the hair removal composition of the present application.

[0032] Secondly, embodiments of this application provide the application of the hair removal composition described above in pet hair removal products.

[0033] Based on the fact that the hair removal composition described above has a good hair removal effect and few side effects, when used in hair removal products, this hair removal composition can effectively improve the hair removal effect of hair removal products and reduce the side effects of hair removal products.

[0034] In some embodiments, the hair removal product may be hair removal cream, hair removal tablets, etc., and the specific product is not limited.

[0035] Thirdly, embodiments of this application provide a pet food for removing hairballs. The pet food for removing hairballs according to embodiments of this application comprises the following components in parts by weight: 0.5-2 parts barley grass powder; Wheatgrass powder 0.1~0.5 parts; 2-10 parts of psyllium husk powder; Fructooligosaccharides 1.5 to 3 parts; Yucca 0.1~0.5 parts; The hair-removing composition is 0.2 to 1.6 parts; The hair-removing composition is the hair-removing composition described above.

[0036] The hair-removing composition in the pet food of this application embodiment effectively promotes the expulsion of hairballs. Psyllium husk powder contains a large amount of soluble fiber; these highly absorbent soluble fibers form a gel that lubricates and wraps around the hair, softens feces, and regulates the microecology. Barley grass powder and wheat grass powder are rich in insoluble fibers such as cellulose and hemicellulose. These insoluble fibers stimulate the intestines and mimic herbivorous behavior, thereby promoting physical hair removal. Yucca and fructooligosaccharides can regulate the flora, promote digestion and absorption, and improve the intestinal environment. This not only directly enhances intestinal function but also indirectly assists in hair removal. The saponins, polysaccharides, and polyphenols in yucca can increase the length of intestinal villi, improve intestinal structure and the ability to absorb nutrients, regulate the balance of intestinal flora, reduce intestinal burden, and alleviate inflammation. As a non-digestible fiber, fructooligosaccharides can selectively promote the proliferation of beneficial bacteria such as Bifidobacteria and enhance the activity of intestinal immune cells. The hair removal pet food of this application further improves the hair removal effect by combining the hair removal composition described above with barley grass powder, wheat grass powder, psyllium husk powder, fructooligosaccharides and yucca. This makes the hair removal pet food not only have a good hair removal effect, but also improve the intestinal health of cats and other animals, relieve cats' discomfort, and promote cats' health.

[0037] In some embodiments, the weight parts of the hair-removing composition in the hair-removing pet food of this application embodiment can be 0.2 to 1.5 parts. In exemplary examples, it can be a typical but non-limiting number of parts such as 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, and 1.5 parts, or any weight part between any two values. Controlling the weight parts of the hair-removing composition in the hair-removing pet food of this application embodiment within this range can further improve the hair-removing effect of the hair-removing pet food and prevent hairballs.

[0038] In some embodiments, the soluble fiber content of psyllium husk powder can be ≥70%. In exemplary cases, the soluble fiber content of psyllium husk powder can be 70%, 75%, or 80%, and is not specifically limited. Controlling the soluble fiber content of psyllium husk powder within this range can further promote hairball lubrication and fecal softening in cats, thereby promoting hair removal and further improving the hair removal effect of the hair removal pet food of the embodiments of this application.

[0039] In some embodiments, the mesh size of barley grass powder can be 80-500 mesh, and the mesh size of wheat grass powder can also be 80-500 mesh. By controlling the particle size of barley grass powder and wheat grass powder within this range, the taste and texture of the hair removal pet food of this application embodiment are further optimized, the cat's acceptance of the hair removal pet food is improved, and the dispersibility of barley grass powder and wheat grass powder in the hair removal pet food is further improved, and the contact area between barley grass powder and wheat grass powder and intestinal mucosa is increased, thereby further promoting hair removal and improving the hair removal effect of the hair removal pet food.

[0040] In some embodiments, the pet food for hair removal in this application may further include a compound palatable agent. In an example, the compound palatable agent may include at least one of chicken liver powder, chicken hydrolysate, and yeast hydrolysate. Chicken liver powder, as a nutrient-rich pet food additive, has abundant nutrients that can meet the daily needs of pets for various vitamins and minerals, and the nutrients in chicken liver powder are easily digested and absorbed by pets. The compounding of chicken liver powder with yeast hydrolysate, chicken hydrolysate, etc., further enriches the nutritional components, promotes nutrient absorption, and thus further improves the nutritional value of the pet food for hair removal in this application; it also improves palatability, reduces the rate of pet refusal to eat, and promotes active licking, thereby further enhancing the palatability of the pet food for hair removal in this application.

[0041] In a further embodiment, the weight percentage of the compounded palatability agent can be 46.5 to 47.5 parts, specifically 46.5, 46.8, 47, 47.3, or 47.5 parts, which are typical but not limiting values, or any weight percentage between any two values. By controlling the weight percentage of the compounded palatability agent within this range, the palatability of the pet food for removing hair is further improved, and its nutritional value is enhanced, while ensuring the hair removal effect of the pet food in this application embodiment.

[0042] In some embodiments, the hair removal pet food of this application may further include collagen. In a further embodiment, the collagen may include at least one of bovine hide collagen, fish collagen, and bovine bone collagen. In an exemplary embodiment, the collagen may be fish collagen. In a further embodiment, the weight parts of collagen may be 9-14 parts, and in an exemplary embodiment, it may be 10 parts. Fish collagen contains functional proteins and abundant amino acids. As a potential alternative excipient, it is superior to traditional excipients in terms of nutritional value, biocompatibility, and functional properties. On the one hand, fish collagen can act as a stabilizer and film-forming agent, while having good biocompatibility and biodegradability, and low immunogenicity, thereby reducing the risk of allergic reactions. Adding collagen to the hair removal pet food of this application further enriches and improves the nutritional content, while also making the hair removal pet food more formable, thus facilitating the production of tablets and other easily portable and precisely fed forms.

[0043] In some embodiments, the pet food containing hair removal products according to this application may also include complex mineral elements. In an example, the complex mineral elements may include at least one of methionine zinc chelate and glycine copper chelate.

[0044] In a further embodiment, the weight percentage of the complex mineral elements can be 0.14 to 1.4 parts, optionally 0.14 to 1 part. Typical but non-limiting weight percentages in exemplary examples include 0.14 parts, 0.15 parts, 0.18 parts, 0.2 parts, 0.5 parts, 0.8 parts, 1 part, 1.2 parts, and 1.4 parts, or any weight percentage between any two values. Methionine zinc chelate and glycine copper chelate are essential nutrients for cat hair growth. Controlling the content of the complex mineral elements within this range further improves poor hair growth and hair loss in cats caused by nutrient deficiencies, and prevents hairballs.

[0045] In some embodiments, the pet food for hair removal in this application may also include B vitamins. In an example, B vitamins may include at least one of vitamin B1, vitamin B2, vitamin B6, and vitamin B12.

[0046] In a further embodiment, the weight percentage of B vitamins can be 0.03 to 0.3 parts, optionally 0.03 to 0.2 parts. Typical but non-limiting weight percentages in the examples include 0.03 parts, 0.05 parts, 0.1 parts, 0.2 parts, and 0.3 parts, or any weight percentage between any two values. B vitamins such as vitamin B1, vitamin B2, vitamin B6, and vitamin B12, as well as complex mineral elements such as zinc methionine chelate and copper glycine chelate, are all essential nutrients for cat hair growth. Controlling the content of B vitamins within this range promotes the organic combination between the components of B vitamins and complex mineral elements. This allows the hair removal pet food of this application embodiment to further improve cat hair growth, maintain cat skin health, alleviate cat hair loss symptoms, thereby reducing hair ingestion, preventing hairballs, further maintaining cat intestinal health, enhancing cat immunity, and thus improving the cat's overall health.

[0047] In some embodiments, the pet food for hair removal in this application may further include vitamin A. In a further embodiment, the weight fraction of vitamin A may be 0.01 to 0.1 parts, and in exemplary cases may be typical but not limiting fractions such as 0.01 parts, 0.02 parts, 0.05 parts, 0.07 parts, 0.1 parts, or any fraction between any two values.

[0048] In some embodiments, the pet food for hair removal in this application may further include vitamin E. In a further embodiment, the weight of vitamin E may be 0.01 to 0.1 parts, and in exemplary cases may be typical but not limiting parts such as 0.01 parts, 0.02 parts, 0.05 parts, 0.07 parts, 0.1 parts, or any weight of any two values.

[0049] Vitamin A promotes the normal growth and differentiation of cat skin cells, keeping the skin soft and elastic, and making the fur shinier. Vitamin E enhances the skin's antioxidant capacity, reducing free radical damage to the skin and fur, and further reducing hair loss. By controlling the weight percentages of Vitamin A and Vitamin E within this range, the hairball-reducing pet food of this application embodiment can further improve the health of the cat's skin and fur, reduce hair loss, and prevent hairballs.

[0050] The hair removal pet food described in this application can be made into paste (such as hairball paste), tablets (such as hairball tablets), powder, granules, etc., and the specific form is not limited. By making the hair removal food into different product forms, it is possible to better meet the needs of different cats.

[0051] In some embodiments, the pet food for removing hairballs according to this application can be a hairball control tablet, which may include 30-40 parts of microcrystalline cellulose. The hairball control tablet may include the following components in parts by weight: 0.5-2 parts barley grass powder; Wheatgrass powder 0.1~0.5 parts; 2-10 parts of psyllium husk powder; Fructooligosaccharides 1.5 to 3 parts; Yucca 0.1~0.5 parts; The hair-removing composition is 0.2 to 1.6 parts; 9-14 parts collagen; Apply 46.5-47.5 parts of the compound oral solution; 30-40 parts of microcrystalline cellulose.

[0052] In some embodiments, the hair removal tablets of this application may further include at least one of a complex of mineral elements, B vitamins, vitamin A, and vitamin E. In a further embodiment, the hair removal tablets of this application may include 0.14 to 1.4 parts of a complex of mineral elements, 0.03 to 0.3 parts of B vitamins, 0.01 to 0.1 parts of vitamin A, and 0.01 to 0.1 parts of vitamin E.

[0053] Based on the compounding of hair removal composition, barley grass powder, wheat grass powder, and psyllium husk powder, the hair removal tablets of this application have a good hair removal effect. Furthermore, the hair removal tablets of this application, through the compounding of microcrystalline cellulose with the hair removal composition, barley grass powder, wheat grass powder, and psyllium husk powder, have good compressibility and formability, eliminating the need for tablet forming components such as starch and maltodextrin. Since the hair removal tablets of this application do not contain starch or maltodextrin, they are gentle on the cat's digestive system and suitable for cats with special physiological needs or metabolic characteristics such as diabetes, obesity, or sensitive digestive systems. By making the hair removal food of this application into hair removal tablets, feeding convenience is improved, facilitating precise feeding and portability when traveling.

[0054] In some embodiments, the microcrystalline cellulose is PH-102 microcrystalline cellulose with a carbohydrate content of 97-102 w / % . PH-102 microcrystalline cellulose has good flowability and compressibility, which allows it to be better and more uniformly mixed with other components such as the hair removal composition, barley grass powder, wheat grass powder, and psyllium husk powder during the preparation of hair removal tablets. It also improves the compressibility of the hair removal tablet raw materials, enabling the hair removal tablets to have suitable hardness, reducing brittleness and making them easier for dogs and cats to chew.

[0055] In a further embodiment, the collagen in the hairball remedy tablets of this application is fish collagen powder. Fish collagen powder, as a stabilizer and film-forming agent, has wide applications in the food industry, for example, as a good fortifying agent for starchy foods. Fish collagen is a functional protein extracted from fish, rich in amino acids, and has good biocompatibility and biodegradability. The hairball remedy tablets of this application use fish collagen powder to replace the binder excipients in the tablets, giving the hairball remedy tablets good formability and further reducing the digestive burden on cats. In addition, compared to traditional binder excipients, fish collagen powder has a better taste, thereby improving the palatability of the hairball remedy tablets.

[0056] In some embodiments, the weight-average molecular weight of fish collagen is 1000-3000 Da, optionally 1000-2000 Da, 1500-2000 Da, and in exemplary cases, it can be typical but not limiting sizes such as 1000 Da, 1200 Da, 1500 Da, 1800 Da, 2000 Da, 2500 Da, 3000 Da, or any size between any two numerical ranges.

[0057] In some embodiments, the polymer dispersity index (PDI) of fish collagen is ≤3, optionally ≤1.5. Typical but not limited values ​​in examples include 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 2.2, 2.4, 2.8, and 3, or any value between any two ranges. Controlling the weight-average molecular weight of fish collagen and controlling its PDI within this range further improves its viscosity and adhesive properties, thereby improving properties such as the brittleness of the collagen flakes.

[0058] In some embodiments, the content of fish collagen powder can be 9 to 14 parts, optionally 10 to 12 parts, and in exemplary cases, it can be 9, 10, 11, 12, 13, 14 parts, or any weight part number between any two values. Controlling the molecular weight and weight part number of fish collagen powder within this range further improves the properties of the hairball remedy, reduces its brittleness, and makes it easier for dogs and cats to chew and digest.

[0059] In some embodiments, the hair removal products of this application may include the following components in parts by weight: 2 parts barley grass powder; 0.5 parts wheatgrass powder; Two parts of psyllium husk powder; 1.5 parts of fructooligosaccharides; Yucca 0.1 parts; 0.8 parts of the hair-removing composition; 6 portions of fish collagen powder; 46.5 parts of compound oral solution; 39 parts of microcrystalline cellulose.

[0060] In a further embodiment, the hair removal products of this application may include the following components in parts by weight: 2 parts barley grass powder; 0.5 parts wheatgrass powder; Two parts of psyllium husk powder; 1.5 parts of fructooligosaccharides; Yucca 0.1 parts; 0.8 parts of the hair-removing composition; 46.5 parts of compound oral solution; 39 parts of microcrystalline cellulose; 0.14 parts of complex mineral elements; 0.03 servings of B vitamins; Vitamin A 0.01 part; Vitamin E 0.01 parts.

[0061] By controlling the formulation ratio of the hair removal tablets in the embodiments of this application, the performance and efficacy of the hair removal tablets are further optimized, the hair removal effect is improved, the formability of the hair removal tablets is improved, the breakage rate of the hair removal tablets during production and storage is reduced, the integrity and stability of the product are guaranteed, and the texture of the hair removal tablets is made more uniform, making it easier for cats to chew and digest, thus further improving the convenience of cats to eat.

[0062] Fourthly, this application provides a method for preparing hair removal pet food. The method for preparing hair removal pet food according to this application includes the following steps: Barley grass powder, wheat grass powder, psyllium husk powder, yucca, fructooligosaccharides, and hair removal composition are mixed and processed to obtain hair removal pet food.

[0063] The method for preparing hair removal pet food in this application embodiment involves a mixing process to combine barley grass powder, wheat grass powder, psyllium husk powder, yucca, fructooligosaccharides, and a hair removal composition, thereby obtaining a hair removal pet food with good hair removal effect. Furthermore, the method for preparing hair removal pet food in this application embodiment has few steps and the process parameters are easy to control.

[0064] In some embodiments, when the hair removal pet food is a hairball remedy tablet, the method for preparing the hairball remedy tablet may include the following steps: Step S01: Wheat seedling powder, psyllium husk powder, yucca, compound granulating agent and microcrystalline cellulose are premixed, granulated, dried and sized in proportion to obtain premixed granules; Step S02: The premixed granules are mixed with barley grass powder, fructooligosaccharide and hair removal composition to obtain a total mixture; Step S03: Compress the total mixture to obtain a tablet.

[0065] By premixing, granulating, and mixing the raw materials for hairball remedies, uniform mixing is achieved, resulting in a more even distribution of components in the compressed tablets. Each tablet delivers a stable hair removal effect. Furthermore, the granulation process improves the flowability of the raw materials, facilitating subsequent tableting and ensuring the quality of the tablets. The hairball remedies prepared using the method described in this application are easy to package, transport, and store, reducing the risk of damage during distribution. In practical applications, the dosage of hairball remedies is easy to control. The appropriate number of tablets can be accurately provided to a cat based on its age, weight, and coat condition, thereby achieving a better hair removal effect while minimizing side effects.

[0066] Step S01: In step S01, wheat seedling powder, psyllium husk powder, yucca, fish collagen powder, compounding agent and microcrystalline cellulose are premixed in proportion to obtain premixed powder. The premixed powder is then mixed with water to prepare a soft material, which is then granulated, dried and sized to obtain premixed granules.

[0067] In some embodiments, the drying temperature can be 45-50°C, and the drying time can be 30 minutes. By controlling the drying temperature and time within this range, the activity of each component can be effectively maintained while removing moisture from the particles, thereby further improving the efficacy of the desiccant tablets.

[0068] Step S02: In step S02, the premixed granules are mixed with barley grass powder, fructooligosaccharides and the hair removal composition to obtain a total mixture, which further improves the mixing uniformity of each component, while effectively preserving the activity of keratinase and Enterococcus faecalis in the hair removal composition.

[0069] Step S03: By performing tableting in step S03, the total mixed powder is made into tablets, which makes the hair removal food of this application embodiment easy to package, store and transport, and easy to accurately control the feeding amount, thereby further enhancing the hair removal effect of the hair removal pet food of this application embodiment.

[0070] In order to enable those skilled in the art to clearly understand the above-described implementation details and operations of this application, and to demonstrate the significant improvement in the performance of the hair removal composition and its application in the embodiments of this application, the above technical solutions are illustrated below through multiple embodiments.

[0071] Example A1 This embodiment provides a hair removal composition. The hair removal composition of this embodiment includes keratinase and Enterococcus faecalis, with a mass ratio of keratinase to Enterococcus faecalis of 1:10.

[0072] The Enterococcus faecium sample was Enterococcus faecium JYEF-35, manufactured by Shandong Weiman Pet Food Co., Ltd., with preservation number CGMCC No. 27222, and a live count ≥ 1.0*10⁻⁶. 10 CFU / g, product standard code Q / 370781SJY 044. Keratinase is 100,000 kcal / g keratinase powder, strain source: Bacillus licheniformis; strain number: 02. Manufacturer: Jinan Bestjet Biotechnology Co., Ltd., specification: 3x10. 10 CFU / kg.

[0073] Examples A2 to A10 Examples A2 to A8 each provide a hair removal composition. The hair removal compositions of Examples A2 to A8 are basically the same as the hair removal composition of Example A1, except that the proportions of keratinase and Enterococcus faecalis in the hair removal compositions of Examples A2 to A8 are shown in Table 1.

[0074] Comparative Example A1 Comparative Example A1 provides a hair removal composition. The hair removal composition of Comparative Example A1 comprises keratinase and Bacillus subtilis in a mass ratio of 3:5, wherein the viable Bacillus subtilis content is ≥1.0*10⁻⁶. 10 CFU / g.

[0075] Table 1

[0076] Example B1 This embodiment provides a hair removal pet food. The hair removal pet food in this embodiment is a hair removal tablet. The formula for the hair removal tablet in this embodiment is shown in Tables 2 and 3, wherein the hair removal composition in the hair removal tablet in this embodiment is the hair removal composition in Example A1.

[0077] The preparation method of the hair removal patch in this embodiment includes the following steps: Step S01: Pass all raw material components through a 60-mesh sieve and set aside.

[0078] Step S02: Take the prescribed amounts of wheatgrass powder, psyllium husk powder, compound mineral elements, B vitamins, yucca, fish collagen powder, compound oral remedy, and microcrystalline cellulose, and add them to a mixer in equal increments for premixing. Mix for five minutes to obtain a premixed powder. The fish collagen powder has a weight-average molecular weight of 1500 and a PDI of 2.63. The compound mineral elements include methionine zinc chelate and glycine copper chelate in a mass ratio of 10:1. The compound oral remedy includes chicken liver powder, chicken hydrolysate, and yeast hydrolysate in a mass ratio of 45.5:1:1. The B vitamins include vitamin B1, vitamin B2, vitamin B6, and vitamin B12 in a mass ratio of 0.0178:0.004:0.0033:0.0082.

[0079] Step S03: Mix purified water with the premixed powder from step S02, stir evenly to obtain a soft material, sieve and granulate to obtain wet granules.

[0080] Step S04: Take the wet granules from step S03, dry them at 50℃±5℃ for 30 minutes, and granulate them by passing them through a 60-mesh sieve to obtain dry granules.

[0081] Step S05: Take the dry granules from step S04 and mix them with the prescribed amounts of barley grass powder, hair removal composition and fructooligosaccharide to obtain a total mixed powder.

[0082] Step S06: Take the total mixed powder from step S05 and compress it into tablets to obtain the chemically treated tablets of this embodiment.

[0083] Examples B2 to B10 Examples B2 to B10 each provide a hair removal pet food. Examples B2 to B8 are all hair removal pet foods that are hairball control tablets. The hairball control tablets of Examples B2 to B8 are basically the same as those of Example B1, except that the formulas for the hairball control tablets of Examples B2 to B8 are shown in Table 3.

[0084] In Example B2, the hair-removing composition in the hair-removing tablet is the same as that in Example A2; in Example B3, the hair-removing composition in the hair-removing tablet is the same as that in Example A3; and so on, in Example B10, the hair-removing composition in the hair-removing tablet is the same as that in Example A10.

[0085] Example B11 Example B11 provides a hair removal pet food. The hair removal pet food in Example B11 is a hair removal tablet. The hair removal tablet in Example B11 is basically the same as the hair removal tablet in Example B1, except that the hair removal tablet in this example does not contain fish collagen powder.

[0086] Because the formula for the hair removal tablets in Example B11 does not contain fish collagen powder, it is difficult to prepare the soft material. When preparing the soft material, the raw materials are easy to disperse and difficult to form into clumps.

[0087] Examples B12 to B18 Examples B12 to B18 each provide a hair removal tablet. The hair removal tablets of Examples B12 to B18 are basically the same as those of Example B1, except that the weight proportions of fish collagen powder in Examples B12 to B18 are different. Specific details of the hair removal tablets of Examples B1 and Examples B12 to B18 are shown in Table 2.

[0088] Table 2

[0089] As shown in Table 2, when the fish collagen powder content is low, the binding performance is insufficient, resulting in a friability of over 5% in the hair removal tablets. Conversely, when the fish collagen powder content is high, the tablets are hard (greater than 60N), making them difficult for dogs and cats to chew and increasing their digestive burden. Controlling the fish collagen powder content within a specific range effectively improves the friability and other properties of the hair removal tablets, while reducing the digestive burden on dogs and cats, further improving the hair removal effect. Furthermore, replacing traditional binders such as starch paste and sodium carboxymethyl cellulose with appropriate amounts of fish collagen powder in the hair removal tablets not only enhances their nutritional value but also increases their consumption rate by dogs and cats.

[0090] Comparative Example B1 Comparative Example B1 provides a hair removal pet food, which is a hair removal tablet. Comparative Examples B1 to B4 all provide hair removal pet foods that are essentially the same as the hair removal tablet in Example B1, except that the hair removal composition in the hair removal tablet in Comparative Example B1 is the same as the hair removal composition in Comparative Example A1.

[0091] Comparative Example B2 Comparative Example B2 provides a hair removal pet food, which is a hair removal tablet. Comparative Examples B2 to B4 all contain hair removal pet foods that are essentially the same as the hair removal tablet in Example B1, except that the hair removal tablet in Comparative Example B2 does not contain a hair removal composition.

[0092] Table 3

[0093] animal experiments (1) Experiment on the effect of cat palatability on overall health status Experimental samples: Hair removal films from Examples B1 to B8 and Comparative Examples B1 to B4.

[0094] Experimental animals and management: 31 healthy adult cats, including 5 American Shorthairs, 1 Siamese, 5 domestic shorthairs, 15 British Shorthairs, and 5 Ragdolls, aged 1-4 years.

[0095] Test Methods: Before the experiment, the experimental cats were placed in a cattery for physical exercise and socialization. Only water was provided during this period; no food was given. Thirty-one cats were tested with different implementation examples and comparative hair patches, with a feeding amount of 2 patches / cat / day. The experimental period was 5 days. Before the next sample was introduced, there was a three-day interval without sample feeding (only regular cat food was fed) to allow the cats to resume their eating habits. For Example B11, since it could not be compressed into tablets, the powder sample of Example B11 was mixed into the main food for testing. The cats' eating habits were recorded, including the time of hesitation before eating and the amount of food consumed. Acceptability analysis was performed, and the results are shown in Table 4.

[0096] Table 4

[0097] As shown in Table 4, the cats' consumption rate of the hairball remedy containing fish collagen powder was greater than 80%, indicating that cats had a high willingness to consume the hairball remedy of the present application embodiments. However, the cats' consumption rate of the sample in Example B11 without fish collagen powder was 77%, lower than other samples containing fish collagen powder. This indicates that the hairball remedy of the present application embodiments, through the combination of fish collagen powder and other components, can improve the cats' consumption rate of the hairball remedy. During the testing process, no abnormalities such as diarrhea, soft stools, or vomiting were observed in any of the cats during the testing period.

[0098] (2) Test of the efficacy of cat hair removal (hair removal) Test samples: Hair removal tablets from Examples B1 to B8 and Comparative Examples B1 to B4.

[0099] Experimental animals and management: Several healthy American Shorthair cats, weighing 4.54±1.36kg, were divided into 12 groups of 6 cats each, with each group consisting of 1-year-old, 2-year-old, and 3-year-old cats.

[0100] Test Method: The test period for each group of hairball remedies was 22 days. From days 1 to 7, cats were fed basal cat food. From days 8 to 22, in addition to the basal cat food feeding amounts shown in Table 5, each cat was supplemented with hairball remedies according to the feeding amounts shown in Table 5. Daily food intake for each cat was recorded during the experiment. At the end of the experiment, the average daily food intake for each cat was calculated. Cats were weighed on days 1, 7, and 21 of the experiment in an empty stomach. Feces were collected, labeled, and packaged daily at 8:00 AM. Store at 20℃. Carefully wash the fecal sample with clean water to remove food residue, dry it, weigh it, and evaluate the fecal morphology using a grading method. Observe the cat daily for any abnormalities such as vomiting, curling up, or slow movement, and observe the cat's mental state for any abnormalities.

[0101] Table 5

[0102] Weight change: The feeding amount for each group of cats was determined according to their energy requirements, and weight data were collected before and after the feeding period. The results showed that there was no significant difference in weight change among the groups of cats after supplementing with hairball remedy (P>0.05).

[0103] A five-point scoring system was used to evaluate the shape and texture of feces in each group of cats participating in the test, thereby reflecting the health of their digestive systems. During the test period, all cats showed normal eating habits, fecal condition, and mental state, and none exhibited abnormalities such as diarrhea, soft stools, or vomiting. Table 4 shows the fecal scores, average total hair weight per cat per day in feces, and average hair-to-feces ratio per cat per day for each group of cats. The fecal appearance of cats fed with hairball remedies in Example 5, Comparative Example B1, and Comparative Example B2 is shown below. Figure 1 As shown.

[0104] Table 6

[0105] The fecal score was calculated as follows: 3 points for soft stool, 3.5 points for slightly soft stool, 4 points for normal stool, and 5 points for constipation. As shown in Table 1, the fecal scores of cats fed different implementation examples and comparative proportions of hair loss tablets were all greater than 3.5 points and less than 4.5 points, and no abnormalities of soft stool or constipation were observed.

[0106] Figure 1 Images of feces and hair from American Shorthair cats in Example B1, Comparative Example B1, and Comparative Example B2 groups on the last day of the efficacy test for hair removal (hair removal) in cats. Figure 1 As shown, in American Shorthair cats that consumed Example B1 hairball remedy (keratinase: Enterococcus faecalis = 3:5), the hair in their feces was almost completely broken down into white protein; in American Shorthair cats that consumed Comparative Example B1 hairball remedy (keratinase: Bacillus subtilis = 3:5), the hair in their feces was partially broken down into white protein; and in American Shorthair cats that consumed Comparative Example B2 hairball remedy (non-hairball composition), the hair in their feces was slightly lighter in color and not significantly broken down.

[0107] As shown in Table 6, after feeding the hair removal tablets of Examples B1 to B10, the amount of hair in the cat feces was significantly greater than that after feeding the hair removal tablets of Comparative Examples B1 and B2. This indicates that the hair removal composition of the present application significantly improves the hair removal effect through the combination of keratinase and Enterococcus faecium.

[0108] Furthermore, as shown in Table 6, from Examples B1 to B10, as the proportion of keratinase and Enterococcus faecium in the hair removal composition of the fed hair removal tablets increased, the hair content in cat feces showed a trend of first increasing and then decreasing after feeding these hair removal tablets. This indicates that by controlling the proportion of keratinase and Enterococcus faecium in the hair removal composition of the embodiments of this application within a specific range, the hair removal effect of the hair removal composition and hair removal tablets can be further improved.

[0109] The above description is merely a preferred embodiment of this application and is not intended to limit this application. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of this application should be included within the protection scope of this application.

Claims

1. A hair-removing composition, characterized in that, Including keratinase and Enterococcus faecalis.

2. The hair-removing composition according to claim 1, characterized in that, The mass ratio of the keratinase to the Enterococcus faecalis is 1:8 to 8:

1.

3. The hair-removing composition according to claim 2, characterized in that, The mass ratio of the Enterococcus faecalis to the keratinase is 3:2 to 3:5; and / or The keratinase activity is ≥100,000 u / g; and / or The Enterococcus faecalis is Enterococcus faecalis JYEF-355; and / or The viable count of the Enterococcus faecalis is ≥10. 10 CFU / g; and / or The preservation number of the Enterococcus faecalis is CGMCC No. 27222.

4. The use of the hair removal composition according to any one of claims 1-3 in pet hair removal products.

5. A pet food for removing hairballs, characterized in that, The components include the following parts by weight: The hair-removing composition is the hair-removing composition as described in any one of claims 1-3.

6. The pet food for removing hairballs as described in claim 5, characterized in that, The psyllium husk powder has a soluble fiber content of ≥70%; and / or The hair removal pet food further includes at least one of the following: compound oral care agent, collagen, compound mineral elements, B vitamins, vitamin A, and vitamin E, and the hair removal pet food satisfies any one of the following (1) to (8): (1) The compound mouthwash is in the form of 46.5 to 47.5 parts by weight; (2) The collagen is in the form of 9 to 14 parts by weight; (3) The collagen is fish collagen, and the weight-average molecular weight of the fish collagen is 1000-3000 Da; (4) The collagen is fish collagen, and the PDI of the fish collagen is ≤3; (5) The weight percentage of the composite mineral elements is 0.14 to 1.4 parts; (6) The B vitamins are present in a weight ratio of 0.03 to 0.3 parts; (7) The vitamin A content is 0.01 to 0.1 parts by weight; (8) The vitamin E is in the amount of 0.01 to 0.1 parts by weight.

7. The pet food for removing hairballs as described in claim 6, characterized in that, The compound mouthwash includes at least one of chicken liver powder, hydrolyzed chicken powder, and yeast hydrolysate; and / or The complex mineral elements include at least one of methionine zinc chelate and glycine copper chelate; and / or The B vitamins include at least one of vitamin B1, vitamin B2, vitamin B6, and vitamin B12; and / or The hair removal pet food is a hair removal tablet, which comprises 30-40 parts microcrystalline cellulose and 9-14 parts fish collagen; and / or The weight-average molecular weight of the fish collagen is 1000–2000 Da; and / or The PDI of the fish collagen is ≤1.

5.

8. The pet food for removing hairballs as described in any one of claims 5-7, characterized in that, The hair removal pet food is a hairball remedy tablet, which comprises the following components in parts by weight: The hair removal composition includes 0.3 parts of keratinase and 0.5 parts of Enterococcus faecalis.

9. A method for preparing a pet food for removing hairballs, characterized in that, Includes the following steps: Barley grass powder, wheat grass powder, psyllium husk powder, yucca, fructooligosaccharides, and hair removal composition are mixed and processed to obtain hair removal pet food.

10. The preparation method according to claim 9, characterized in that, The hair removal pet food is a hairball remedy tablet, and the preparation method of the hairball remedy tablet includes the following steps: Wheat seedling powder, psyllium husk powder, yucca, fish collagen powder, compounding agent and microcrystalline cellulose were premixed, granulated, dried and sized in proportion to obtain premixed granules. The premixed granules were mixed with barley grass powder, fructooligosaccharides and hair removal composition to obtain a total mixture. The total mixture is compressed into tablets to obtain the fuzzy tablets.

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