Colloidal silver and plant ear mite removing composite composition as well as preparation method and application thereof

Abstract

The invention relates to the technical field of veterinary drugs, and particularly discloses a colloidal silver and plant ear mite removing composite composition as well as a preparation method and application thereof. The composition is prepared from 0.1 wt%-0.5 wt% of colloidal silver, 0.1 wt%-0.5 wt% of 4-terpineol, 0.2 wt%-1 wt% of blumea oil, 10 wt%-30 wt% of a surfactant, 1.5 wt%-6 wt% of composite extracts (extracts of melia azedarach, geranium and hamamelis virginiana), 0.01 wt%-0.1 wt% of a complexing agent, 2 wt%-8 wt% of an organic solvent, deionized water and the like. Through synergism of all the components, the effects of resisting bacteria, killing mites, resisting inflammation and cleaning are achieved, and the problems of pet ear mite infection and ears are comprehensively solved. The invention also provides a preparation method of the composition, through step-by-step treatment, the activity of the components is ensured, and the stability and safety of the product are improved. The composition can be prepared into an ear mite removing product for pets, so that the ear health of the pets is effectively nursed.

Description

Technical Field

[0001] This invention relates to the field of veterinary drug technology, and in particular to a colloidal silver and plant-based ear mite compound composition, its preparation method, and its application. Background Technology

[0002] With the rapid development of the pet economy, the pet health care market is showing a high-speed growth trend. According to the "2023 China Pet Industry White Paper," the size of China's pet market has exceeded 300 billion yuan, with pet medical and care products accounting for an increasing proportion year by year. Ear health is one of the common problems for pets (especially dogs and cats), with frequent issues such as ear mites, fungal infections, and earwax buildup, indicating a clear market demand.

[0003] There are two common methods for mite control: internal and external. Internal control primarily involves administering oral medications, while external control mainly uses sprays or drops. External control is more convenient and has fewer side effects, making it more widely used. However, existing sprays and drops often contain chemicals, requiring application to specific areas of the pet's body to prevent licking and adverse reactions. Furthermore, to enhance the effectiveness of chemical mite-killing agents, large amounts of penetration enhancers and organic solvents (such as ethanol) are typically added to sprays or drops. These penetration enhancers, organic solvents, and chemical mite-killing agents can cause significant irritation, often harming pets with weaker constitutions, such as dogs and cats.

[0004] In view of the above-mentioned technologies, the inventors believe that it is necessary to develop a mite-removing compound composition that has good mite-removing effect and high safety. Summary of the Invention

[0005] To address the shortcomings of existing technologies, this application provides a colloidal silver and plant-based ear mite removal composite composition, its preparation method, and its application.

[0006] In a first aspect, this application provides a composite composition of colloidal silver and plant-based ear mite removal agents, employing the following technical solution: A compound composition of colloidal silver and plant-based ear mite treatment comprises: 0.1–0.5 wt% colloidal silver, 0.1–0.5 wt% 4-terpineol, 0.2–1 wt% Artemisia argyi oil, 10–30 wt% surfactant, 1.5–6 wt% compound extract, 0.01–0.1 wt% complexing agent, 2–8 wt% organic solvent, and deionized water to a final concentration of 100%; wherein the compound extract comprises Neem extract, Geranium extract, and Witch hazel extract.

[0007] By employing the above-mentioned technical solutions, colloidal silver penetrates bacterial cell membranes, interferes with enzyme activity, and damages DNA, effectively inhibiting Gram-positive and Gram-negative bacteria in the ear canal. 4-Terpineol supplements the antifungal ability by destroying the cell membranes of fungi such as Candida and Malassezia, causing their death, while simultaneously inhibiting the release of inflammatory factors to alleviate redness, swelling, heat, and pain. The two work synergistically to achieve complementary protection through "bacteriostasis + fungicide + anti-inflammation." In the mite-removal system, Artemisia argyi oil directly kills ear mites with its volatile components and forms a repellent barrier; Neem extract interferes with the nerve conduction of ear mites to block their development and reproduction; Geranium extract enhances the repellent effect and destroys the lipid layer on the mite's surface, causing dehydration; Witch hazel extract astringes the ear canal mucosa, reducing the humid environment. These four components work synergistically to form a closed loop of "immediate killing + blocking reproduction + physical destruction + environmental improvement," significantly improving mite-removal efficiency. Surfactants remove earwax, cerumen, and other secretions, preventing them from blocking contact between active ingredients and pathogens, indirectly improving the efficiency of each component. Each component is scientifically regulated to ensure activity while avoiding irritation, ultimately achieving a synergistic effect of antibacterial, mite-removing, anti-inflammatory, and cleaning properties, comprehensively solving ear mite infections and related ear problems in pets.

[0008] Preferably, the surfactant is one or more of PEG-40 hydrogenated castor oil, AEO-9, sodium diethylhexyl sulfosuccinate, and APG1214.

[0009] By adopting the above technical solution, one or more of PEG-40 hydrogenated castor oil, AEO-9, sodium diethylhexyl sulfosuccinate and APG1214 are selected as surfactants. This not only has strong cleaning ability and can effectively remove earwax, cerumen and other secretions in the ear canal, but also promotes the dispersion and dissolution of each component in the composition, improves the stability and uniformity of the system, and enhances the product's performance.

[0010] Preferably, the complexing agent is one or more of disodium ethylenediaminetetraacetate and sodium thiosulfate.

[0011] By adopting the above technical solution, using one or more of disodium ethylenediaminetetraacetate and sodium thiosulfate as a complexing agent, metal ions in the system can be chelated, avoiding interference of metal ions with the stability of other active ingredients (such as colloidal silver, plant extracts, etc.), thereby maintaining the chemical stability of the composition and extending the shelf life of the product.

[0012] Preferably, the organic solvent is one or more of propylene glycol, 1,3-butanediol, and glycerol.

[0013] By adopting the above technical solution and selecting one or more of propylene glycol, 1,3-butanediol, and glycerin as organic solvents, the fat-soluble components (such as 4-terpineol, Artemisia argyi oil, plant extracts, etc.) in the composition can be effectively dissolved, thereby improving the compatibility of these components in the system, ensuring uniform dispersion of each component, and enhancing the stability and effectiveness of the product.

[0014] Preferably, the colloidal silver and plant-based ear mite removal composite composition has its pH value adjusted to 5-7 using a pH adjuster.

[0015] By adopting the above technical solution, the pH value of the composition is adjusted to 5-7, which is compatible with the physiological pH environment of the pet's ear canal. This can maintain the normal microecological balance of the ear canal, reduce the stimulation of the ear canal mucosa caused by improper pH value, reduce the risk of ear discomfort or damage, and is more conducive to the health of the pet's ears.

[0016] Preferably, the pH adjuster is one or more of triethanolamine, ammonia, sodium citrate, sodium hydroxide, and potassium hydroxide.

[0017] By adopting the above technical solution, one or more of triethanolamine, ammonia, sodium citrate, sodium hydroxide, and potassium hydroxide are used as pH adjusters. The adjustment effect is mild and can accurately control the pH value of the composition within a suitable range of 5 to 7. It also has low irritation to the ear canal mucosa, ensuring the safety and comfort of product use.

[0018] Preferably, the colloidal silver and plant-based ear mite removal composite composition further includes a fragrance.

[0019] By adopting the above technical solution, adding fragrance to the composition can mask any odor that may be produced after the ingredients are mixed, improve the product's odor experience, and enhance pets' acceptance of the product and the pet owner's operating experience.

[0020] Secondly, this application provides a method for preparing a composite composition of colloidal silver and plant-based ear mite removers, using the following technical solution: A method for preparing a composite composition of colloidal silver and plant-based ear mite repellent includes the following steps: S1: Add the organic solvent and half the amount of water in the formula to the reaction vessel, stir and heat to 45°C; S2: Add the surfactant to the reactor and stir until homogeneous, then add the complexing agent to the reactor and stir until completely dissolved; S3: After the temperature of the reactor drops below 30°C, add 4-terpineol, Artemisia argyi oil, compound extract and colloidal silver to the reactor in sequence and stir until homogeneous; S4: Take the solution obtained in step S3 and test its pH value. Adjust the pH value to 5-7. S5: Filter the pH-adjusted solution through a 0.45μm microporous membrane and then store it.

[0021] By adopting the above technical solution, this preparation method, through step-by-step processing (first heating to dissolve surfactants and complexing agents, then cooling before adding heat-sensitive components such as 4-terpineol, plant extracts, colloidal silver, etc.), can avoid the destruction of active ingredients by high temperatures and ensure the efficacy and stability of each component; the subsequent pH adjustment and 0.45μm microporous membrane filtration steps can ensure that the product pH is suitable and remove impurities, further improving the purity, stability and safety of the product.

[0022] Thirdly, this application provides a pet ear mite removal product, which adopts the following technical solution: A pet ear mite removal product comprising the above-mentioned colloidal silver and plant-based ear mite removal composite composition.

[0023] By adopting the above technical solution, the combined effects of antibacterial, anti-mite, anti-inflammatory, and cleaning properties of the composition can be directly exerted, which can specifically solve the problem of ear mite infection in pets, while relieving ear inflammation and discomfort, maintaining the health of pets' ears, and providing effective ear care for pets.

[0024] In summary, this application has the following beneficial effects: 1. The composition of this application establishes a multi-stage mechanism of action against ear mites through the precise combination of various plant ingredients. Artemisia oil, with its volatile active ingredients, directly kills ear mites upon contact, rapidly reducing their numbers in the ear canal while forming a continuous repellent barrier to reduce re-invasion by external mites. Neem extract targets and interferes with the ear mite's neural transmission system, blocking its physiological cycles of feeding, development, and reproduction, thus inhibiting the expansion of the mite population at its source and preventing rebound after short-term eradication. Geranium extract enhances the repellent effect through its volatile components and also destroys the lipid protective layer on the ear mite's surface, causing rapid water loss and death, thus strengthening the physical killing effect. Witch hazel extract astringes the ear canal mucosa, regulates ear canal humidity, improves the moist microenvironment on which ear mites depend for survival, and reduces their breeding grounds. These four ingredients form a closed loop from "immediate killing," "reproduction blocking," "physical destruction," to "environmental improvement," achieving comprehensive and long-term control of ear mites.

[0025] 2. The components of this application are complementary and mutually reinforcing in efficacy, forming a powerful synergistic effect. In terms of antibacterial properties, colloidal silver inhibits ear canal flora by disrupting bacterial cell membranes, interfering with enzyme systems, and damaging DNA, while 4-terpineol supplements antifungal capabilities (targeting Candida, Malassezia, etc.). Together, they reduce secondary bacterial and fungal infections caused by ear mite infestations. In terms of anti-inflammatory properties, 4-terpineol inhibits the release of inflammatory factors, relieving ear canal redness, swelling, heat, and pain. Combined with the anti-mite ingredients, it quickly alleviates discomfort caused by ear mite irritation in pets. In terms of cleansing properties, surfactants remove earwax, cerumen, and other secretions, preventing these substances from blocking contact between the anti-mite and antibacterial ingredients and the target pathogens, indirectly enhancing the efficiency of the active ingredients. Simultaneously, the proportions of all components are scientifically controlled to ensure high efficacy while minimizing irritation to the ear canal mucosa, ensuring both "powerful mite removal" and "gentle care." This multi-dimensional synergistic effect allows the composition to not only effectively eliminate ear mites but also simultaneously address inflammation and flora imbalance caused by infection, comprehensively maintaining the health of pet ears. Detailed Implementation

[0026] The present application will be further described in detail below with reference to the embodiments.

[0027] All raw materials used in the embodiments of this invention are conventional commercially available products.

[0028] Example 1

[0029] A colloidal silver and plant-based ear mite repellent composite composition comprises the following raw materials by weight percentage: 0.1% colloidal silver, 0.1% 4-terpineol, 0.2% Artemisia argyi oil, 10% PEG-40 hydrogenated castor oil, 1% AEO-9, 1% sodium diethylhexyl sulfosuccinate and 1% APG1214, 0.5% Neem extract, 0.5% Geranium extract, 0.5% Witch hazel extract, 0.01% sodium thiosulfate, 8% 1,3-butanediol, pH adjuster, 0.1% fragrance and replenished to 100% deionized water.

[0030] The pH adjuster is triethanolamine, which is used to adjust the pH to 5-7.

[0031] This embodiment also provides a method for preparing the above-mentioned colloidal silver and plant-based ear mite removal composite composition, the steps of which are as follows: S1: Add 1,3-butanediol and half the amount of water in the formula to the reaction vessel, start stirring and heat to 45°C; S2: Add PEG-40 hydrogenated castor oil to the reaction vessel and stir until homogeneous. Then add sodium thiosulfate to the reaction vessel and stir for 15 minutes until completely dissolved. S3: Add sodium diethylhexyl sulfosuccinate, AEO-9, and APG1214 to a mixing tank and stir until homogeneous; S4: After the temperature of the reactor drops below 30°C, add 4-terpineol, Artemisia argyi oil, witch hazel extract, neem extract, geranium extract, colloidal silver and fragrance in sequence, and stir for another 15 minutes. S5: Take an appropriate amount of solution to test the pH value. If the pH value is in the range of 5 to 7, there is no need to add pH adjuster to adjust the pH value. If the pH value is not in the range of 5 to 7, dissolve triethanolamine in an appropriate amount of water and add it to make the pH value between 5 and 7, and then add the remaining deionized water. S6: Filter the pH-adjusted solution through a 0.45µm microporous membrane and then store it.

[0032] Example 2

[0033] A colloidal silver and plant-based ear mite repellent composite composition comprises the following raw materials by weight percentage: 0.2% colloidal silver, 0.2% 4-terpineol, 0.5% Artemisia argyi oil, 14% PEG-40 hydrogenated castor oil, 2% AEO-9, 2.5% sodium diethylhexyl sulfosuccinate and 2% APG1214, 1% Neem extract, 1% Geranium extract, 1% Witch hazel extract, 0.05% disodium EDTA, 5% propylene glycol, pH adjuster, 0.1% fragrance and replenished to 100% deionized water.

[0034] The pH adjuster is triethanolamine, which is used to adjust the pH to 5-7.

[0035] This embodiment also provides a method for preparing the above-mentioned colloidal silver and plant-based ear mite removal composite composition, the steps of which are as follows: S1: Add propylene glycol and half the amount of water in the formula to the reaction vessel, turn on the stirring and heat to 45°C; S2: Add PEG-40 hydrogenated castor oil to the reaction vessel and stir until homogeneous. Then add disodium ethylenediaminetetraacetate to the reaction vessel and stir for 15 minutes until completely dissolved. S3: Add sodium diethylhexyl sulfosuccinate, AEO-9, and APG1214 to a mixing tank and stir until homogeneous; S4: After the temperature of the reactor drops below 30°C, add 4-terpineol, Artemisia argyi oil, witch hazel extract, neem extract, geranium extract, colloidal silver and fragrance in sequence, and stir for another 15 minutes. S5: Take an appropriate amount of solution to test the pH value. If the pH value is in the range of 5 to 7, there is no need to add pH adjuster to adjust the pH value. If the pH value is not in the range of 5 to 7, dissolve triethanolamine in an appropriate amount of water and add it to make the pH value between 5 and 7, and then add the remaining deionized water. S6: Filter the pH-adjusted solution through a 0.45µm microporous membrane and then store it.

[0036] Example 3

[0037] A colloidal silver and plant-based ear mite repellent composite composition comprises the following raw materials by weight percentage: 0.5% colloidal silver, 0.5% 4-terpineol, 1% Artemisia argyi oil, 20% PEG-40 hydrogenated castor oil, 3% AEO-9, 4% sodium diethylhexyl sulfosuccinate and 3% APG1214, 2% Neem extract, 2% Geranium extract, 2% Witch hazel extract, 0.1% disodium EDTA, 2% glycerin, pH adjuster, 0.1% fragrance and replenished to 100% deionized water.

[0038] The pH adjuster is triethanolamine, which is used to adjust the pH to 5-7.

[0039] This embodiment also provides a method for preparing the above-mentioned colloidal silver and plant-based ear mite removal composite composition, the steps of which are as follows: S1: Add glycerin and half the amount of water in the formula to the reaction vessel, turn on the stirring and heat to 45°C; S2: Add PEG-40 hydrogenated castor oil to the reaction vessel and stir until homogeneous. Then add disodium ethylenediaminetetraacetate to the reaction vessel and stir for 15 minutes until completely dissolved. S3: Add sodium diethylhexyl sulfosuccinate, AEO-9, and APG1214 to a mixing tank and stir until homogeneous; S4: After the temperature of the reactor drops below 30°C, add 4-terpineol, Artemisia argyi oil, witch hazel extract, neem extract, geranium extract, colloidal silver and fragrance in sequence, and stir for another 15 minutes. S5: Take an appropriate amount of solution to test the pH value. If the pH value is in the range of 5 to 7, there is no need to add pH adjuster to adjust the pH value. If the pH value is not in the range of 5 to 7, dissolve triethanolamine in an appropriate amount of water and add it to make the pH value between 5 and 7, and then add the remaining deionized water. S6: Filter the pH-adjusted solution through a 0.45µm microporous membrane and then store it.

[0040] The pH adjuster used in the above embodiments can also be replaced with one or more of ammonia, sodium citrate, sodium hydroxide, and potassium hydroxide for pH adjustment.

[0041] Comparative Example 1 An ear mite removal compound composition, which differs from Example 2 in that it does not contain colloidal silver.

[0042] Comparative Example 2 An ear mite removal compound composition, which differs from Example 2 in that it does not contain 4-terpineol and Artemisia argyi oil.

[0043] Performance testing 1. Stability Test Test subject: Sample of composition from Example 2.

[0044] Test method: The composition samples of Examples 1-3 were placed under two conditions, high temperature (60℃) and strong light (4500+500Lx), respectively, to conduct the high temperature and strong light influence factor test. After being placed for 10 days, the samples were tested at 0 days, 5 days, and 10 days. The standard for qualified stability is a colorless and transparent liquid with a relative density of 0.96 to 1.04 g / mL and a pH value of 5.0 to 7.0.

[0045] The test results are shown in Tables 1 and 2.

[0046] Table 1. Results of stability tests under high temperature conditions

[0047] Table 2 Results of stability test under strong light conditions

[0048] As shown in Tables 1 and 2, the compositions of the present invention are stable under high temperature and strong light conditions and meet the standards.

[0049] 2. Antibacterial test Test subjects: the composition sample of Example 2 and Comparative Examples 1-2.

[0050] Test consumables: Staphylococcus aureus test bacteria, Candida albicans test bacteria, 0.5wt% Tween 80, phosphate buffer solution (PBS, 0.03mol / L, pH 7.2), nutrient agar, Sabouraud dextrose agar medium.

[0051] Test method: The experiment was conducted in accordance with the quantitative bactericidal specifications in the "Technical Specifications for Identification of Veterinary Disinfectants" (1992) issued by the Ministry of Agriculture (Agricultural (Animal Husbandry) No. 101).

[0052] The prepared mixed bacterial suspension was subjected to viable cell count, and then diluted with a diluent to a concentration of 10⁻⁶ bacteria. 5 ~10 7The test bacterial suspension was prepared using cfu / ml. The original sample solution was used as the test solution. 0.5 ml of the test bacterial suspension was added to 4.5 ml of the test solution at the test concentration. The test solution and bacterial suspension were mixed and allowed to react for 30 and 60 minutes. After the reaction time, 0.5 ml of the above bacterial-drug mixture was immediately added to 4.5 ml of neutralizing agent and mixed thoroughly. After neutralization for 10 minutes, 0.5 ml of the mixture was added to 4.5 ml of diluent and mixed thoroughly. 0.1 ml of the mixture was spread evenly on nutrient agar and Sabouraud dextrose agar. The nutrient agar was incubated at 35°C for 18–24 h, and the colony count was recorded. The Sabouraud dextrose agar was incubated at 28°C for 24–48 h, and the colony count was recorded. The diluted solution was used instead of the test solution, and the above steps were performed simultaneously as a positive control group.

[0053] The test results are shown in Tables 3, 4, and 5: Table 3. Antibacterial test results of samples from Example 2

[0054] Table 4. Antibacterial test results of Comparative Example 1.

[0055] Table 5. Antibacterial test results of Comparative Example 2 samples

[0056] As shown in Tables 3-5, the composition sample of Example 2 of the present invention has a good antibacterial effect. Even after treatment under high temperature and strong light conditions, it can maintain an antibacterial effect of more than 97% (Candida albicans and Staphylococcus aureus). In contrast, the conventional antibacterial effect of the composition samples of Comparative Example 1 and Comparative Example 2 is less than 90% after 30 minutes. The antibacterial effect is far inferior to that of the composition of the present invention, indicating that the colloidal silver of the present invention has a significant synergistic effect with 4-terpineol and Artemisia argyi oil, and is irreplaceable.

[0057] 3. Clinical testing Test subjects: Composition samples of Example 2 and Comparative Examples 1-2.

[0058] Test method: Select 6 cats infected with ear mites. Use the test twice a week. Each time, fill the ear canal with enough test sample, gently massage the ear, and then clean it with a cotton swab. Count the ear mites 1 day before use, and 1, 4, 7, 14, 21 and 28 days after the first use. Record the earwax / cerumen condition of the cats at each examination time. This will be used as the test result for otitis media.

[0059] The earwax / cerumen condition is rated on a scale of 0 to 3, with 3 indicating severe earwax / cerumen and 0 indicating no earwax / cerumen or very little earwax.

[0060] The test results are shown in Table 6-10 below.

[0061] Table 6. Clinical test results of the composition in Example 2 for ear mites.

[0062] Table 7. Clinical test results of the composition in Comparative Example 1 for ear mites.

[0063] Table 8. Clinical test results of the composition in Comparative Example 2 for ear mites.

[0064] Table 9. Ear canal inflammation test scores.

[0065] As shown in Table 6, after using the composition of Example 2, the reduction rate of ear mites in most cats reached approximately 100% by day 4, and the reduction rate of ear mites in all cats reached 100% by day 7. Subsequent follow-up observation until day 28 showed no recurrence of ear mites. In contrast, the data in Tables 7-8 show that in Comparative Example 1, only most cats in the test group achieved a reduction rate of approximately 100% for ear mites by day 7, and it wasn't until day 14 that the reduction rate of ear mites in all cats reached 100%. Comparative Example 2 performed even worse; even by day 28, the reduction rate of ear mites in all cats had not reached 100%, and some even experienced a resurgence of ear mites, indicating a significantly poor mite-removal effect.

[0066] According to the data in Table 9, on the 4th day after using the care solution of Example 2, the earwax / cerumen scores of the cats in the test group had all dropped to 1 point; by the 7th day, the scores had all reached 0 points, meaning that most of the earwax / cerumen had been removed, fully demonstrating that the composition was effective and fast-acting in treating feline otitis media. Although the composition of Comparative Example 1 had a certain therapeutic effect on feline otitis media, it took until the 14th day for all cats to have their earwax / cerumen scores drop to 0 points; while Comparative Example 2 was completely ineffective in treating feline otitis media, and even after observing until the 28th day, the earwax / cerumen scores of all cats remained at 1 point.

[0067] 4. Stimulation test Test subjects: compositions of Example 2 and Comparative Examples 1-2.

[0068] Test method: According to the clinical trial grouping, the test group cats were recorded at 0h, 0.5h, 1h and 2h after the sample was used to see whether they scratched their ear canals, had ear canal skin allergies, or had adverse reactions such as restlessness, drooling and frequent meowing.

[0069] The test results are shown in Table 10.

[0070] Table 10 Results of Stimulation Tests

[0071] After using the sample of the composition of Example 2, no scratching of the ear canal or ear canal skin allergy was observed in the test group cats at 0h, 0.5h, 1h and 2h. The cats also did not have adverse reactions such as anxiety, drooling or frequent meowing, indicating that the ear canal care solution of Example 2 is mild and non-irritating.

[0072] This specific embodiment is merely an explanation of this application and is not intended to limit it. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they fall within the scope of the claims of this application.

Claims

1. A colloidal silver and plant ear mite complex composition characterized in that, It comprises: 0.1-0.5wt% colloidal silver, 0.1-0.5wt% 4-terpineol, 0.2-1wt% folium artemisiae argyi oil, 10-30wt% surfactant, 1.5-6wt% composite extract, 0.01-0.1wt% complexing agent, 2-8wt% organic solvent and deionized water to 100%; the composite extract comprises neem extract, geranium extract and hamamelis virginiana extract.

2. The colloidal silver and plant ear mite complex composition according to claim 1, characterized in that: The surfactant is one or more of PEG-40 hydrogenated castor oil, AEO-9, sodium sulfosuccinic acid diethylhexyl ester and APG1214.

3. The colloidal silver and plant ear mite complex composition according to claim 1, characterized in that: The complexing agent is one or more of disodium ethylenediaminetetraacetate and sodium thiosulfate.

4. The colloidal silver and plant ear mite complex composition according to claim 1, characterized in that: The organic solvent is one or more of propylene glycol, 1,3-butanediol and glycerol.

5. The colloidal silver and plant ear mite complex composition according to claim 1, characterized in that: The colloidal silver and plant ear mite composite composition is adjusted to pH 5-7 by a pH adjuster.

6. The colloidal silver and plant ear mite complex composition according to claim 5, characterized in that: The pH adjuster is one or more of triethanolamine, ammonia, sodium citrate, sodium hydroxide and potassium hydroxide.

7. The colloidal silver and plant ear mite complex composition according to claim 1, characterized in that: The colloidal silver and plant ear mite composite composition further comprises essence.

8. A process for the preparation of a colloidal silver and plant ear mite complex composition as claimed in any one of claims 1 to 7, characterised in that, It comprises the following steps: S1: add organic solvent and half of the water in the formulation to the reaction kettle, stir and warm to 45℃; S2: add surfactant to the reaction kettle and stir until uniform, then add complexing agent to the reaction kettle and stir until completely dissolved; S3: after the temperature of the reaction kettle drops to below 30℃, sequentially add 4-terpineol, folium artemisiae argyi oil, composite extract and colloidal silver to the reaction kettle and stir until uniform; S4: take the solution obtained in step S3 and detect the pH value, and adjust the pH value to 5-7; S5: filter the solution with a pH value that meets the requirements through a 0.45μm microporous filter membrane, and then store.

9. A pet ear mite product characterized by: The colloidal silver and plant ear mite composite composition according to any one of claims 1-7.

10. Use of the colloidal silver and plant ear mite composite composition according to any one of claims 1-7 for pet ear mite removal.

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