Traditional Chinese medicine compound preparation for promoting wound healing of equus animals

Abstract

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine compound preparation for promoting equus animal wound healing, which is technically characterized by being prepared from dried alum, slaked lime, calcined gypsum, myrrh, dragon's blood, frankincense, puffball and borneol according to a specific weight part ratio. Through a scientific formula, toxic medicinal materials such as yellow lead, realgar, calomel and the like in traditional preservative and tissue regeneration promoting powder are thoroughly replaced, and the risk of heavy metal poisoning is fundamentally eradicated; the formula is designed according to the physiological characteristics of thick skin, easy seepage of wound surfaces and slow healing of equus animals, all the medicines cooperate to jointly achieve the effects of astringing and promoting tissue regeneration, promoting blood circulation to arrest pain, resisting inflammation and expelling parasites, and the composition has the advantages of being fast in healing of various wounds of the equus animals, high in safety and convenient to use.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine compound preparation for promoting wound healing of equidae. BACKGROUND

[0002] The incidence of skin wounds of equidae (including horses, donkeys, mules, etc.) is extremely high during their feeding, training and use. Due to the physiological and management characteristics of equidae, such as relatively thick skin, loose subcutaneous tissue, more exudate after wound, wound surface easily contaminated by urine and feces, and disturbed by mosquitoes and flies, etc., the wound healing process of equidae is often slower and more complex than other domestic animals, which is easy to develop into chronic wounds or secondary severe infections, causing significant losses to the breeding industry and economy.

[0003] In the traditional veterinary practice, the classical prescription "Fangsuo Shengji Powder" has been widely used for the treatment of animal wounds. The prescription is usually composed of Huangdan (mainly composed of Pb3O4), Xionghuang (mainly composed of As2S2) and Qingfen (mainly composed of Hg2Cl2). Although it has certain astringent and muscle-regenerating effects, the heavy metal elements such as lead (Pb), arsenic (As) and mercury (Hg) contained in the above-mentioned medicinal materials have clear and strong toxicity. In practical application, the above-mentioned toxic components will bring double harm: first, the irritant produced after the drug is applied to the wound will cause the animal to lick, bite or rub the wound repeatedly due to discomfort, resulting in the ingestion of the drug through the mouth, causing acute or chronic heavy metal poisoning, damaging the nervous system, digestive system and kidney function; second, even if the animal does not lick, these fine toxic powders can be directly absorbed into the blood circulation through the damaged skin and wound tissue, causing accumulative poisoning to the body, and the long-term use has great safety risks. Therefore, the prescription containing such heavy metal medicinal materials has been strictly limited in clinical application.

[0004] In order to avoid the above-mentioned toxicity problems, some improved external preparations have appeared in the prior art, but all have their own limitations. For example, some technical solutions use single heat-clearing and detoxifying or muscle-regenerating and astringent medicinal materials, which although have improved safety, but often have single drug effect, and are difficult to cope with the complex and diverse types of wounds of equidae, especially for wounds with more exudate, the astringent and drying effect is insufficient. Some other solutions turn to modern dosage forms, such as preparing traditional Chinese medicine into ointments or gels. However, such dosage forms usually need to add oil or high molecular excipients such as sesame oil and vaseline as the matrix. For equidae, which have the nature of liking to lick, the use of ointments is extremely easy to cause digestive disorders due to the ingestion of too much oil; at the same time, the oil matrix may block the wound, affecting the evaporation of exudate, which creates conditions for the growth of anaerobic bacteria, which is not conducive to the cleaning and healing of the wound.

[0005] In addition, the current market for veterinary wound drugs are general preparations, and do not fully consider the unique physiological and pathological characteristics of equidae, and lack a comprehensive and targeted solution that can simultaneously achieve rapid convergence and moisture absorption, high efficiency anti-inflammatory analgesia, promotion of granulation tissue regeneration, and to a certain extent, mosquito and fly repelling.

[0006] Therefore, the skilled in the art has long been committed to the study of a safe, efficient and convenient Chinese medicine compound preparation that can completely replace traditional toxic prescriptions and overcome the defects of the prior art, which is specifically directed to wound healing of equidae.

[0007] To this end, the present application provides a Chinese medicine compound preparation for promoting wound healing of equidae to solve the above problems. SUMMARY

[0008] The present application aims to solve the technical problems raised in the background art, and provides a Chinese medicine compound preparation for promoting wound healing of equidae.

[0009] The above-mentioned object of the present application is achieved in the following manner: The present application provides a Chinese medicine compound preparation for promoting wound healing of equidae, which is prepared from raw medicinal materials in the following proportions by weight: Potassium alum 8-15 parts, lime 5-10 parts, calcined gypsum 5-15 parts, myrrh 6-12 parts, dragon's blood 3-8 parts, frankincense 3-8 parts, callopilava 3-10 parts, and borneol 1-3 parts.

[0010] Further, the preparation is prepared from raw medicinal materials in the following proportions by weight: Potassium alum 10 parts, lime 10 parts, calcined gypsum 9 parts, myrrh 9 parts, dragon's blood 5 parts, frankincense 5 parts, callopilava 3 parts, and borneol 1 part.

[0011] Further, the dosage form of the preparation is a powder.

[0012] The present application also provides a preparation method of a Chinese medicine compound preparation for promoting wound healing of equidae, which comprises the following steps: S1, pretreatment of medicinal materials: remove impurities from potassium alum and dry at 60°C; pass lime through a 20-mesh sieve to remove coarse particles; freeze dragon's blood and frankincense at -5°C for 1 hour and then crush them; S2, crushing and sieving: crush each pre-treated medicinal material and then pass through a 100-mesh sieve; S3, mixing and homogenizing: mix the sieved fine powder of each medicinal material in the proportions by weight as claimed in claim 1 or 2 into a mixer and mix for 30 minutes until uniform; S4, quality inspection and packaging: perform quality inspection on the mixed uniform powder and package after passing the inspection.

[0013] Further, the step S2 adopts a super micro pulverizer for pulverization.

[0014] Further, the rotating speed of the mixing machine in the step S3 is 180 r / min.

[0015] Further, the quality detection in the step S4 includes microbial limit test and heavy metal content test.

[0016] The scheme of the present application also provides a use of the traditional Chinese medicine compound preparation in the preparation of a medicine for treating trauma of equidae.

[0017] Further, the trauma is abrasion, laceration or suppurative wound surface.

[0018] Compared with the prior art, the present application has the following beneficial effects: 1. The safety of the compound preparation of the scheme of the present application is significantly improved (compared with the classic prescription and the existing general veterinary medicine): (1) The toxic components such as lead, arsenic and mercury in the original "Fangsong Shengji Powder" are completely removed, and no equidae has toxic symptoms during the medication, so the safety is much higher than that of the traditional prescription containing heavy metals; (2) There is no oil and fat auxiliary material (such as sesame oil and vaseline) in the ointment form of the prior art, so that the equidae is prevented from ingesting too much oil and fat due to licking and causing digestive problems; 2. The curative effect of the compound preparation of the scheme of the present application is adapted to the special needs of equidae (compared with the existing general veterinary medicine): (1) According to the characteristics of thick skin and easy liquid penetration of equidae, the "dry alum + lime + calcined gypsum" is used to cooperate with moisture absorption and wound fixation; (2) The eight kinds of traditional Chinese medicines cooperate with each other, and the fresh abrasion wound of equidae can be basically healed after 7 days of medication.

[0019] (3) The compound preparation is suitable for a wider type of wound, and can be used for fresh abrasion, laceration after suture and suppurative wound of equidae, and the prior art is mainly suitable for mild abrasion and has limited effect on suppurative wound; 3. The application scene of the compound preparation of the scheme of the present application is flexible (compared with the complex process of the prior art): (1) The preparation process does not need expensive equipment such as Co60 sterilization, only needs conventional traditional Chinese medicine processing equipment, and the pasture can directly produce on a large scale, so that the batch production cost is reduced compared with the existing ointment form; (2) The powder form is packaged with an aluminum-plastic composite bag, does not need refrigeration, is convenient to carry, and can be directly applied on the spot of the equidae injury, which perfectly adapts to the emergency treatment demand of the pasture in the wild. BRIEF DESCRIPTION OF DRAWINGS

[0020] Figure 1 is the preparation method flow chart in the embodiment of the present application; Figure 2 is the wound healing state photo of the test horse after using the preparation of the present application for one week in the embodiment of the present application. DETAILED DESCRIPTION

[0021] In order to make the purpose, technical scheme and advantages of the present application more clear, the present application is further described in detail below in combination with the drawings and examples. It should be understood that the specific examples described herein are only used to explain the present application and do not limit the present application.

[0022] The implementation of the present application is described in detail below in combination with specific examples.

[0023] Example: Preparation and effect verification of the best ratio of compound preparation I. Test materials and equipment Medicinal materials: 100 g of calcined alum, 100 g of aged lime, 90 g of calcined gypsum, 90 g of myrrh, 50 g of dragon's blood, 50 g of frankincense, 30 g of calvatia, and 10 g of borneol (total weight 520 g) are weighed according to the best ratio.

[0024] Equipment: traditional Chinese medicine super micro grinder, double motion mixer, 100 mesh stainless steel sieve, constant temperature drying oven.

[0025] II. Preparation steps of the preparation Pretreatment of medicinal materials: Calcined alum: remove lumpy impurities, dry at 60°C for 2 hours to a moisture content of ≤8%.

[0026] Aged lime: remove coarse particles through a 20 mesh sieve and sterilize at 121°C for 30 minutes.

[0027] Dragon's blood and frankincense: cut into 1 cm pieces, freeze at -5°C for 1 hour, and then crush.

[0028] Crushing and sieving: Put the pretreated medicinal materials into the super micro grinder respectively, and crush at a speed of 3000 r / min for 5 minutes.

[0029] Pass all the crushed powder through a 100 mesh sieve and collect the fine powder.

[0030] Mixing and homogenization: Put the above fine powder into the double motion mixer according to the ratio, and mix at a speed of 180 r / min for 30 minutes.

[0031] Sample detection, mixing uniformity RSD is 1.5% (meeting the requirement of ≤2%).

[0032] Quality inspection and packaging: Quality test result: total bacterial count 680 cfu / g, total mold count 32 cfu / g; lead content 3.1 mg / kg, arsenic content 1.4 mg / kg, mercury content 0.07 mg / kg. All indexes meet the predetermined standards.

[0033] The qualified medicine powder is divided into aluminum-plastic composite bags, 100 g per bag, sealed and stored in the dark.

[0034] III. Drug use and effect observation Test object: healthy adult Yili horses are selected, and fresh abrasion wounds of 8 cm x 10 cm are made on the rib.

[0035] Drug use method: the powder is directly and evenly applied to the wound once a day.

[0036] Effect observation: as shown in the table, the left side is the state of the just injured horse, and the right side is the state of the horse after using the improved anti-corrosion Shengji powder for one week. During the period, no other operation is performed except for the medicine application. Figure 2 Figure 2 Figure 2 Conclusion: The present application has good therapeutic effect on fresh abrasion, sutured tear, and purulent wounds of equidae animals, has no risk of infection, and meets the diversified needs of pasture for wound treatment. The traditional Chinese medicine compound preparation provided by the present application has excellent effects of rapid healing, safety and non-toxicity on wounds of equidae animals.

[0037] The above only describes the preferred embodiments of the present application and is not intended to limit the present application. Any modification, equivalent replacement and improvement within the spirit and principle of the present application shall be included in the protection scope of the present application.​​​

Claims

1. A traditional Chinese medicine compound preparation for promoting wound healing in equine animals, characterized in that, The preparation is made from the following raw medicinal materials by weight: Glauber's salt 5-10 parts, calcined gypsum 5-15 parts, myrrh 6-12 parts, dragon's blood 3-8 parts, frankincense 3-8 parts, calvatia 3-10 parts, and borneol 1-3 parts.

2. The traditional Chinese medicine compound preparation according to claim 1, characterized in that, The preparation is made from the following raw medicinal materials by weight: Glauber's salt 10 parts, calcined gypsum 9 parts, myrrh 9 parts, dragon's blood 5 parts, frankincense 5 parts, calvatia 3 parts, and borneol 1 part.

3. The traditional Chinese medicine compound preparation according to claim 1 or 2, characterized in that, The dosage form of the preparation is powder.

4. A method for preparing the traditional Chinese medicine compound preparation according to any one of claims 1-3, characterized in that, The method comprises the following steps: S1, medicinal material pretreatment: remove impurities from Glauber's salt and dry it at 60°C; pass Glauber's salt through a 20-mesh sieve to remove coarse particles; freeze dragon's blood and frankincense at -5°C for 1 hour and then crush them; S2, crushing and sieving: crush each kind of pretreated medicinal material and then pass it through a 100-mesh sieve; S3, mixing and homogenization: put the sieved fine powder of each kind of medicinal material into a mixer according to the weight ratio as claimed in claim 1 or 2, and mix for 30 minutes until uniform; S4, quality inspection and packaging: perform quality inspection on the mixed uniform powder, and package it after passing the inspection.

5. The method of claim 4, wherein, In step S2, the crushing is performed by using a supermicro grinder.

6. The method of claim 4, wherein, In step S3, the rotating speed of the mixer is 180 r / min.

7. The method of claim 4, wherein, In step S4, the quality inspection comprises microbial limit test and heavy metal content test.

8. Use of the traditional Chinese medicine compound preparation according to any one of claims 1-3 in the preparation of a medicament for treating trauma of equidae.

9. Use according to claim 8, characterized in that, The trauma is abrasion, laceration, or suppurative wound surface.

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