Biomarkers for detecting PARP1 function and application thereof
By screening out a group of highly specific PARP1 functional biomarkers, the problem of low PARP1 detection specificity in existing technologies has been solved, enabling a more efficient tumor diagnosis and treatment strategy and reducing the risk of side effects.
CN121380313APending Publication Date: 2026-01-23SHENZHEN UNIV
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Patent Information
- Application Number
- CN202511256489.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-09-04
- Publication Date
- 2026-01-23
AI Technical Summary
Technical Problem
Existing technologies for PARP1 detection have low specificity, complex detection methods, and stringent requirements for sample collection, making them difficult to meet the needs of clinical applications.
Method used
A set of biomarkers, including CBX5, CKAP2, NKTR, PTCH1, and ZNF318, are provided to detect PARP1 function. By screening out functional marker genes with high specificity to PARP1, new targeted therapies can be developed for tumor diagnosis and prognosis prediction.
Benefits of technology
It improves the specificity and sensitivity of PARP1 detection, broadens the treatment options for PARP1-related diseases, reduces the risk of side effects, and provides a more efficient cancer treatment strategy.
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Abstract
The invention relates to the field of biological medicine, and discloses a biomarker for detecting a PARP1 function and application of the biomarker, and the biomarker comprises CBX5, CKAP2, NKTR, PTCH1, ZNF318, CENPF, ARID4B, CDK19, SRCAP, CELF2, CBFA2T3, TIAM1, SARDH, IDI1, BIRC6, PAN3, PRSS23, ITGA2, PROCR, S100A2, GRN, IFIT1, MMP1, RBPMS, JAG1, IFI27, OASL, HMGA2, SPHK1, KLF10, MYO10, ARRDC4, PLAUR, IER3, PTGS2, ANKRD29 and The biomarker is a regulatory gene of the PARP1, and has higher specificity than that of the PARP1.
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