Visual quantitative lavage device for laboratory mouse

Abstract

The invention provides a visual quantitative gavage device for laboratory mice, and particularly relates to the technical field of biological experiment instruments.The visual quantitative gavage device comprises a fixed bottom plate, a supporting frame is fixedly connected to the center of the top face of the fixed bottom plate, the laboratory mice are restrained in the mode that the belly faces downwards in the laboratory mouse restraining process, and the situation that when an experimenter manually restrains the laboratory mice, the laboratory mice are restrained by the supporting frame is avoided; according to the lavage device, four limbs of an experimental mouse easily scratch the hand of an experimenter, after the experimental mouse is restrained and fixed, the body of the experimental mouse can be automatically turned over by 180 degrees, so that the experimental mouse is finally inclined upwards, and the experimenter can conduct lavage operation conveniently, and compared with the mode that the experimental mouse is manually held by hand and then the abdomen of the experimental mouse is inclined upwards, the lavage operation is more convenient. The automatic rotating mode is more convenient, the laboratory mouse can be stably kept in the overturned posture, the situation that in the prior art, lavage operation is unstable only by holding the laboratory mouse manually is avoided, and the stability and safety of lavage operation of the laboratory mouse are improved.

Description

Technical Field

[0001] This invention provides a visual quantitative gavage device for laboratory mice, specifically relating to the field of biological experimental equipment technology. Background Technology

[0002] A laboratory mouse gavage device is a device that can precisely deliver a specific dose of drug solution or suspension directly into the stomach of a laboratory mouse. Currently, in clinical practice, the operator typically holds the mouse, inserts a syringe needle into the mouse's esophagus, and then manually pushes the syringe plunger to inject the medication directly into the mouse's stomach.

[0003] A utility model patent with authorization announcement number CN217525500U discloses a gavage device for laboratory mice. This gavage device has a reasonable structural design, effectively reduces stress response in laboratory mice, is simple to operate, and facilitates insertion of the gavage tube. In use, the device uses a restraint net to hold the laboratory mouse in place, and then uses a syringe with an injection needle for gavage. However, during needle insertion into the mouse's stomach, the restraint net is too soft and cannot effectively restrain the mouse, resulting in poor stability and affecting needle insertion, thus hindering the gavage procedure. Furthermore, in actual gavage, the mouse's head and mouth should generally be tilted upwards to prevent backflow of the administered liquid. In existing manual procedures, the operator typically holds the mouse by its back, tilting its abdomen upwards while holding the back. This process, with one hand holding the mouse and the other holding the syringe, leads to poor stability during gavage. The aforementioned gavage device cannot effectively adjust the mouse's posture. In addition, some laboratory mice excrete secretions during the gavage process. If these secretions are left directly on the gavage apparatus at the site where the mouse was placed, the next mouse will be covered with the secretions left by the previous mouse after the gavage is completed, thus affecting the hygiene of the gavage procedure.

[0004] Therefore, this invention proposes a visual quantitative gavage device for laboratory mice to compensate for and improve the shortcomings of the prior art. Summary of the Invention

[0005] In view of the deficiencies of the existing technology, the present invention provides a visual quantitative gavage device for laboratory mice, which can effectively solve the related technical problems mentioned in the background art.

[0006] To achieve the above objectives, the present invention provides the following technical solution:

[0007] This invention discloses a visual quantitative gavage device for laboratory mice, including a fixed base plate, four suction cups are uniformly fixedly connected to the bottom of the fixed base plate, and a support frame is fixedly connected to the center of the top surface of the fixed base plate.

[0008] A manual restraint mechanism is provided above the support frame. The manual restraint mechanism includes an inclined shaft rotatably connected to the top of the support frame. A small motor is fixedly mounted on the upper surface of the support frame near the inclined shaft. The output shaft of the small motor is fixedly connected to the inclined shaft. A restraint chamber is fixedly connected to the outer ring surface of the inclined shaft at the end away from the support frame. A placement block is fixedly mounted on the inner surface of the restraint chamber at the end away from the support frame. The surface of the placement block at the end away from the restraint chamber is a semi-circular arc surface. Symmetrical through-holes are provided on both sides of the top of the restraint chamber. Matching blocks are inserted into each of the through-holes on both sides of the top of the restraint chamber. The bottom surface of each of the two matching blocks has a quarter-circular arc surface. A fixed slot plate is fixedly connected to the outer wall of the restraint chamber at the end near the small motor. Two electromagnets are slidably connected inside the fixed slot plate, and initially, the two electromagnets are located on opposite sides. A moving shaft is fixedly connected to the side of each electromagnet near the restraint chamber. The top end of the moving shaft is connected to the two... The outer walls of the mating blocks are fixedly connected to each other on one side. Return springs are fixedly connected between the outer walls of the two electromagnets on the side away from the moving shaft and the outer walls of both ends of the fixed slot plate. Two horizontal bars are symmetrically fixedly connected to the outer walls of the two placement blocks. Fixed cylinders are fixedly connected to the side of the two horizontal bars on the side they are close to each other. Adjusting rods are respectively provided inside the two ends of the fixed cylinders. A slotted plate is provided at the end of the adjusting rod away from the fixed cylinder. A U-shaped opening for placing the head of the experimental mouse is provided on the side of the constraint chamber away from the fixed slot plate. A vertical slot plate is fixedly connected to the outer wall of the constraint chamber on the side near the fixed slot plate. A vertical slot is provided on the vertical slot plate for placing and constraining the tail of the experimental mouse. Two straight slots are symmetrically opened on the side of the constraint chamber near the U-shaped opening. Two threaded rods are symmetrically rotatably connected to the outer wall of the constraint chamber on the side near the straight slots. A clamping plate is threaded onto each of the two threaded rods. The end of the clamping plate away from the threaded rod is located inside the straight slot. A concave strip is fixedly connected between the two clamping plates.

[0009] Preferably, airbags are provided on the quarter-circular arc surface of the bottom surface of both mating blocks.

[0010] Preferably, the adjusting rod and the fixed cylinder are threaded together, and the end of the adjusting rod away from the fixed cylinder is rotatably connected to the support plate.

[0011] Preferably, both the support plate and the vertical groove plate are made of elastic rubber, and the vertical groove plate is located in the middle of the restraint chamber on the side near the fixed groove plate.

[0012] Preferably, there are two card plates, and each of the two card plates has a horizontal surface and an arc surface on the side that is close to each other, wherein the horizontal surface is located above the arc surface.

[0013] Preferably, an auxiliary gavage mechanism is provided on the side of the restraint chamber away from the fixed groove plate. The auxiliary gavage mechanism includes two grooved strips rotatably connected to the outer wall of the restraint chamber on the side away from the fixed groove plate. The two grooved strips are symmetrically distributed on the outer wall of the restraint chamber. The parts of the two grooved strips rotatably connected to the restraint chamber are tightly fitted. Multiple damping holes are evenly provided at the bottom of the two grooved strips. Damping blocks are slidably connected to the interior of the ends of the two grooved strips away from the restraint chamber. Holes are provided in the center of the interior of the two damping blocks. Built-in springs are fixedly connected to the holes inside the two damping blocks. A damping column is fixedly connected to the end of the built-in spring near the damping hole. The end of the damping column away from the built-in spring is hemispherical, and the hemispherical part is initially inserted into one of the damping holes. Flat rods are fixedly connected to the surfaces of the two damping blocks on the sides that are close to each other. A first clamp is fixedly connected to the end of the flat rod away from the damping block. A second clamp is fixedly connected to the end of the first clamp away from the flat rod.

[0014] Preferably, the damping block is rectangular, and the grooved strip has a damping groove for sliding displacement of the damping block.

[0015] Preferably, both the first and second clips are made of elastic plastic, both are circular rings with notches, and both have anti-slip textures on their inner ring surfaces.

[0016] Preferably, the restraint chamber and the placement block are jointly provided with a mating mechanism. This mechanism includes a coaxial plate fixedly connected to the outer wall of a moving shaft away from the placement block. Multiple abutment plates are uniformly fixedly connected to the bottom surface of the coaxial plate. Each abutment plate is rotatably connected to a torsion spring pawl. A large gear is rotatably connected to the outer wall of the restraint chamber near the torsion spring pawl, and the large gear is located on the horizontal movement path of the torsion spring pawl. A winding shaft is rotatably connected to the outer wall of the restraint chamber near the large gear, and a small gear is fixedly connected to the end of the winding shaft near the large gear. The small gear and the large gear mesh with each other. The outer wall of the constraint chamber away from the winding shaft is fixedly connected to a semi-cylinder one. The semi-cylinder one is detachably connected to a semi-cylinder two away from the constraint chamber. Semi-circular holes are opened inside both ends of the semi-cylinder one and the semi-cylinder two. The two semi-circular holes at the same end form a complete circular hole. There are two complete circular holes. A sleeve shaft is inserted between the two circular holes. A cotton roll is sleeved on the outer ring surface of the sleeve shaft. The free end of the cotton roll away from the sleeve shaft passes through the semi-cylinder one, the constraint chamber, and the placement block. The end that passes through the three is glued to the outer ring surface of the winding shaft.

[0017] Preferably, a cylindrical rod is provided on the side of the second half-cylinder close to the first half-cylinder, and a socket is provided on the first half-cylinder corresponding to the cylindrical rod for tight insertion and engagement of the cylindrical rod. Both the first half-cylinder and the second half-cylinder are made of transparent acrylic material.

[0018] Compared with the known prior art, the technical solution provided by this invention has the following beneficial effects:

[0019] This experimental mouse uses a visual quantitative gavage device. After the experimenter restrains and fixes the mouse, the device can automatically rotate the mouse's body 180 degrees so that it is tilted upwards, so that the experimenter can perform the gavage operation. Compared with the existing technology that manually holds the experimental mouse and tilts its abdomen upwards, the automatic rotation method is more convenient and can also keep the experimental mouse stable in the rotated position. It avoids the instability that occurs when the experimental mouse is simply held by hand for gavage operation in the existing technology, and further improves the stability and safety of the experimental mouse gavage operation.

[0020] By using the combination of placement blocks, mating blocks, and other components, the experimental mice are restrained in a belly-down position during restraint. This prevents the mice from easily scratching the experimenters' hands when they are manually restrained, ensuring the safety of the mice before gavage. At the same time, the mating blocks have a central opening for the experimenters to hold or press down on the mice. Even when restraining and fixing the mice, the experimenters can still press down on the mice through the central opening to further ensure the stability of the mice during restraint.

[0021] The method uses a clamping plate to hold the skin of the top of the mouse's head and neck, thereby indirectly restraining the mouse's head and preventing the mouse's head from moving around when being gavaged through its mouth. Compared with the existing technology that relies on manually holding the mouse by the neck, this method does not require manual holding and thus avoids the possibility of accidental biting.

[0022] By rotating the adjustment rods, the distance between the two brackets on the same side can be adjusted to accommodate the limbs of the experimental mouse to the greatest extent possible. This allows the limbs of the experimental mouse to be better restrained within the slots of the brackets. Both the brackets and the vertical slots are made of elastic rubber, which also has good elasticity and adaptability. This not only reduces the damage caused when restraining the experimental mouse, but also better restrains the limbs and tail of the experimental mouse, which is conducive to the gavage procedure.

[0023] During the process of inserting the injection needle into the stomach of the experimental mouse, the combination of components such as clamp one, clamp two, damping block, and grooved strip provides support and guidance for the syringe during its advancement. Compared with the existing technology of simply holding the syringe manually, this method can ensure the stability of the syringe advancement process. At the same time, with the cooperation of components such as damping column and damping hole, it can prevent the experimenter from inserting the injection needle too quickly, thereby reducing damage to the experimental mouse and ensuring the safety of the gavage operation.

[0024] During the process of inserting the injection needle into the stomach of the experimental mouse, the combination of components such as clamp one, clamp two, damping block, and grooved strip provides support and guidance for the syringe during its advancement. Compared with the existing technology of simply holding the syringe manually, this method can ensure the stability of the syringe advancement process. At the same time, with the cooperation of components such as damping column and damping hole, it can prevent the experimenter from inserting the injection needle too quickly, thereby reducing damage to the experimental mouse and ensuring the safety of the gavage operation.

[0025] During the gavage procedure on multiple mice, the cotton roll can be automatically replaced after each mouse is gavaged. During the roll-up process, the cotton cloth absorbs and carries away the secretions of the mice, avoiding cross-contamination caused by the secretions sticking to different mice. It also reduces the number of manual processing steps.

[0026] Using half-roll 2 and half-roll 1 not only prevents dust from adhering to the surface of the new cotton roll, but the transparent acrylic material also makes it easy for the experimenters to observe the use of the cotton roll in real time, so that the experimenters can replace it in time, thereby improving the practicality of the cotton roll in use. Attached Figure Description

[0027] Figure 1 This is a front-view perspective view of the present invention.

[0028] Figure 2 This is a three-dimensional structural diagram from another perspective of the present invention;

[0029] Figure 3 This is a partial three-dimensional structural diagram of the relevant components at the placement block location of the present invention;

[0030] Figure 4 This is a partial three-dimensional structural diagram of the relevant components at the adjusting rod of the present invention;

[0031] Figure 5 This is a partial three-dimensional structural diagram of the relevant components at the slotted plate of the present invention;

[0032] Figure 6 This is a partial cross-sectional three-dimensional structural view of the straight groove opening of the present invention;

[0033] Figure 7 This is a partial three-dimensional structural diagram of the relevant components at the grooved strip of the present invention;

[0034] Figure 8 This is a partial three-dimensional structural diagram of the relevant components at the damping block of the present invention;

[0035] Figure 9 This is a partial structural diagram of the spring-related components of the present invention;

[0036] Figure 10 This is a partial three-dimensional structural diagram of the relevant components of the first and second clips of the present invention in use.

[0037] Figure 11 This is a partial three-dimensional structural diagram of the relevant components at the coaxial plate of the present invention;

[0038] Figure 12 This is a partial three-dimensional structural diagram of the relevant components at the torsion spring pawl of the present invention.

[0039] The markings in the diagram represent:

[0040] 1. Fixed base plate; 11. Support frame; 12. Suction cup;

[0041] Manual restraint mechanism: 21. Inclined shaft; 22. Small motor; 23. Concave strip; 24. Restraint chamber; 25. Placement block; 26. Mating block; 27. Fixed slot plate; 28. Electromagnet; 29. ​​Moving shaft; 210. Return spring; 211. Horizontal bar; 212. Fixed cylinder; 213. Adjusting rod; 214. Support plate; 215. U-shaped opening; 216. Vertical slot plate; 217. Straight slot opening; 218. Threaded rod; 219. Clamping plate;

[0042] Gavage support mechanism: 31. Grooved strip; 32. Damping hole; 33. Damping block; 331. Built-in spring; 332. Damping column; 34. Flat bar; 35. Support clamp one; 36. Support clamp two;

[0043] Coordinating processing mechanisms: 41. Coaxial plate; 42. Support plate; 43. Torsion spring pawl; 44. Large gear; 45. Small gear; 46. Take-up shaft; 47. Half-bowl one; 48. Half-bowl two; 49. Sleeve shaft; 410. Cotton roll. Detailed Implementation

[0044] The present invention will be further described below with reference to embodiments.

[0045] Example 1: As Figure 1 , Figure 2As shown, a visual quantitative gavage device for laboratory mice includes a fixed base plate 1. Four suction cups 12 are evenly fixedly connected to the bottom of the fixed base plate 1, and a support frame 11 is fixedly connected to the center of the top surface of the fixed base plate 1. In use, the four suction cups 12 located at the bottom of the fixed base plate 1 can quickly and easily stabilize the entire visual quantitative gavage device for laboratory mice on the laboratory table, preventing displacement of the gavage device and thus ensuring the stability of the entire gavage device during use.

[0046] As an improvement: such as Figures 1 to 6 As shown, a manual restraint mechanism is provided above the support frame 11. The manual restraint mechanism includes an inclined shaft 21 rotatably connected to the top of the support frame 11. A small motor 22 is fixedly installed on the upper surface of the support frame 11 near the inclined shaft 21. The output shaft of the small motor 22 is fixedly connected to the inclined shaft 21. A restraint chamber 24 is fixedly connected to the outer ring surface of the inclined shaft 21 away from the support frame 11. A placement block 25 is fixedly provided on the inner surface of the restraint chamber 24 away from the support frame 11. The surface of the placement block 25 away from the restraint chamber 24 is a semi-circular arc surface. Through openings are symmetrically opened on both sides of the top of the restraint chamber 24. A mating block 26 is inserted into the through openings on both sides of the top of the restraint chamber 24. The two mating blocks 26 have a central opening in the middle of the side closest to each other, which allows the experimenter to hold or press down the experimental mouse. The bottom surfaces of both mating blocks 26 are provided with a quarter-circular arc surface. Specifically, when the two mating blocks 26 approach and contact each other, the quarter-circular arc surface forms a half-circular arc surface, and this half-circular arc surface, together with the semi-circular arc surface on the placement block 25, forms a complete circle. Airbags are provided on the quarter-circular arc surfaces of the bottom surfaces of both mating blocks 26 to provide flexible restraint for the experimental mice and avoid excessive pressure on their bodies. A fixed slot plate 27 is fixedly connected to the outer wall of the restraint chamber 24 near the small motor 22. Two electromagnets 28 are slidably connected inside the fixed slot plate 27, and initially, the two electromagnets 28 are located on opposite sides. Specifically, the small motor 22 and the two electromagnets 28 are controlled by an external controller. Two electromagnets 28 are each fixedly connected to a moving shaft 29 on the side near the restraint chamber 24. The top of the moving shaft 29 is fixedly connected to the outer wall of the two mating blocks 26 on the side close to each other. Return springs 210 are fixedly connected between the outer wall of the two electromagnets 28 away from the moving shaft 29 and the outer walls of both ends of the fixed slot plate 27. Two horizontal bars 211 are symmetrically fixedly connected to the outer walls of both sides of the placement block 25. Fixed cylinders 212 are fixedly connected to the side of the two horizontal bars 211 close to each other. Adjusting rods 213 are respectively installed inside the two ends of the fixed cylinders 212. A slot plate 214 is installed at the end of the adjusting rod 213 away from the fixed cylinder 212. The adjusting rod 213 is threadedly connected to the fixed cylinder 212, and the end of the adjusting rod 213 away from the fixed cylinder 212 is rotatably connected to the slot plate 214. Figure 1 , Figure 3 , Figure 4As shown, a limiting rod is fixedly connected to one end of the aforementioned bracket 214 near the fixed cylinder 212. The limiting rod is slidably disposed within a limiting groove frame provided on the outer ring surface above the fixed cylinder 212. Specifically, four brackets 214 are provided, symmetrically located in pairs on both sides of the semi-circular arc surface of the placement block 25. Each of the four brackets 214 has a slot for placing the limbs of the experimental mouse, so as to position and restrain the limbs of the experimental mouse using the four brackets 214. The restraint chamber 24 has a U-shaped opening 215 for placing the head of the experimental mouse on the side away from the fixed bracket 27. A vertical slot plate 216 is fixedly connected to the outer wall of the restraint chamber 24 near the fixed bracket 27. The vertical slot plate 216 has a vertical slot for placing and restraining the tail of the experimental mouse. Both the brackets 214 and the vertical slot plate 216 are made of elastic rubber, and the vertical slot plate 216 is located in the middle of the restraint chamber 24 near the fixed bracket 27. Two straight slots 217 are symmetrically opened on the side of the restraint chamber 24 near the U-shaped opening 215. Two threaded rods 218 are symmetrically rotatably connected to the outer wall of the restraint chamber 24 near the straight slots 217. Each threaded rod 218 is threadedly connected to a retaining plate 219. There are two retaining plates 219, and each retaining plate 219 has a flat surface and an arc surface on the side closest to each other, with the flat surface located above the arc surface. The end of the retaining plate 219 away from the threaded rod 218 is located inside the straight slot 217. A concave strip 23 is fixedly connected between the two retaining plates 219. When one retaining plate 219 is adjusted up or down, the other retaining plate 219 will move synchronously. The aforementioned inclined shaft 21, restraint chamber 24, and components on the restraint chamber 24 are all inclined to facilitate the gavage operation of experimental mice by the experimenter.

[0047] In use: The experimenter takes the experimental mouse, holds it by the middle of its back, faces the belly of the experimental mouse towards the semi-circular surface of the placement block 25, and positions the head of the experimental mouse in the position of the U-shaped opening 215, with the mouse's head outside the U-shaped opening 215. Then, the experimental mouse is gradually brought closer to the placement block 25, and its tail is placed in the vertical groove of the vertical groove plate 216, while the experimental mouse's four limbs are placed in the grooves of the corresponding bracket plates 214. During the process, if the limbs of the experimental mouse cannot be properly placed into the slots of the corresponding bracket 214, the experimenter can rotate the adjusting rod 213 to adjust its extension and retraction within the fixed cylinder 212 through threaded rotation, thereby changing the distance between the two brackets 214 on the same side to accommodate the limbs of the experimental mouse to the greatest extent possible. This better restrains the limbs of the experimental mouse within the slots of the bracket 214. Both the bracket 214 and the vertical slot 216 are made of elastic rubber and have good elastic adaptability. This not only reduces the damage caused when restraining the experimental mouse, but also better restrains the limbs and tail of the experimental mouse, which is conducive to the gavage procedure.

[0048] Furthermore, when the mouse's head is placed in the U-shaped opening 215, the experimenter can rotate the threaded rod 218 to move the clamping plate 219 along the trajectory of the straight groove 217, allowing the clamping plate 219 to move up and down according to the height of the mouse's head. This ensures that the arcuate surfaces of the clamping plates 219 on one side align with the contour of the mouse's neck. Subsequently, the experimenter energizes the two electromagnets 28 via an external controller, causing them to move horizontally towards each other. During this process, the return spring 210 is gradually stretched. This causes the corresponding mating blocks 26 to move synchronously towards each other via the two moving shafts 29, ultimately causing the surfaces of the two mating blocks 26 on one side to fit together. At this point, the quarter-circular arcuate surfaces at the bottom of the two mating blocks 26, combined with the semi-circular arcuate surface of the placement block 25, form a complete arcuate surface. In this way, the two mating blocks 26 and the placement block 25 can restrain and fix most of the mouse's body, preventing the mouse from moving around during the gavage process. Therefore, by using the placement block 25, the mating block 26, and other components to restrain the experimental mouse in a belly-down position, the mouse's limbs can easily scratch the experimenter's hands when manually restraining it, ensuring the mouse's safety before gavage. Simultaneously, the mating block 26 has a central opening for the experimenter to hold or press down on the mouse. While restraining and fixing the mouse, the experimenter can still use the central opening to press down on the mouse, further ensuring its stability during restraint. Once the two mating blocks 26, along with the placement block 25, four brackets 214, and the locking plate 219, have completely restrained and fixed the mouse, it is no longer necessary to press down on the mouse by hand.

[0049] Simultaneously, as the two mating blocks 26 move closer to each other horizontally, they also cause the threaded rod 218 and the clamping plate 219 to move synchronously. This causes the arc surface of the clamping plate 219 to come into contact with the head of the experimental mouse, thereby using the flat surface of the clamping plate 219 to hold the skin of the top of the head and neck of the experimental mouse. This indirectly restrains the head of the experimental mouse and prevents the head from moving around when the experimental mouse is given a gavage through its mouth. Compared with the existing technology that relies on manually holding the neck of the experimental mouse, this method does not require manual holding and thus avoids the possibility of accidental biting while holding the mouse manually.

[0050] Subsequently, the researchers activated the small motor 22 via the controller, causing the inclined shaft 21 to rotate 180 degrees. This caused the confinement chamber 24 to rotate synchronously, ultimately resulting in a 180-degree rotation of the confinement chamber 24 and all its components. This also caused the restrained mouse to be flipped 180 degrees, with its head and mouth tilted upwards, allowing the researchers to insert an injection needle through its mouth for gavage. Therefore, after restraining and securing the mouse, the researchers can automatically flip its body 180 degrees, tilting it upwards with its mouth facing upwards, facilitating gavage. Compared to existing technologies that manually hold the mouse and tilt its abdomen upwards, this automatic rotation method is more convenient and ensures the mouse remains stably in the flipped position. It avoids the instability that can occur with manual gavage in existing technologies, further improving the stability and safety of gavage procedures.

[0051] Example 2: Figure 1 , Figures 7 to 10 As shown, a visual quantitative gavage device for laboratory mice also includes an auxiliary gavage mechanism disposed on the side of the restraint chamber 24 away from the fixed groove plate 27. The auxiliary gavage mechanism includes two grooved strips 31 rotatably connected to the outer wall of the restraint chamber 24 away from the fixed groove plate 27. The parts of the two grooved strips 31 rotatably connected to the restraint chamber 24 are tightly fitted. Multiple damping holes 32 are evenly opened at the bottom of the two grooved strips 31. A damping block 33 is slidably connected inside the end of the two grooved strips 31 away from the restraint chamber 24. The damping block 33 is rectangular. The grooved strips 31 are provided with damping grooves for the damping block 33 to slide and displace, so as to ensure the stability of the damping block 33 sliding in the damping groove of the grooved strip 31. Two damping blocks 33 have holes in their centers. Built-in springs 331 are fixedly connected to the holes in both damping blocks 33. A damping post 332 is fixedly connected to the end of the built-in spring 331 closest to the damping hole 32. The end of the damping post 332 furthest from the built-in spring 331 is a hemispherical surface, initially inserted into one of the damping holes 32. Flat rods 34 are fixedly connected to the surfaces of the two damping blocks 33 closest to each other. A clamp 35 is fixedly connected to the end of the flat rod 34 furthest from the damping block 33. A clamp 36 is fixedly connected to the end of the clamp 35 furthest from the flat rod 34. Both clamps 35 and 36 are made of elastic plastic and are notched rings. The inner ring surfaces of both have anti-slip textures to facilitate inserting the syringe for gavage into clamp 36 and to insert the end of the syringe near the injection needle into clamp 35.

[0052] When using this syringe: To ensure the stability of the syringe needle during gavage in laboratory mice, and to avoid injury to the mouse due to excessively rapid insertion, the following precautions should be taken: Figure 10 As shown, the experimenter takes a syringe for gavage and inserts its lower end into clamp 36, while simultaneously inserting the end of the syringe near the injection needle into clamp 35. With the syringe secured by clamps 35 and 36, the injection needle is positioned precisely relative to the mouse's mouth. The experimenter then holds the syringe and moves the needle towards the mouse's mouth. Specifically, the syringe moves along the trajectory defined by clamps 35 and 36; that is, the experimenter holds the syringe and moves clamps 35, the flat rod 34, and the damping block 33 along the damping groove in the grooved strip 31 towards the mouse's mouth. During this movement, the hemispherical surface of the damping column 332 presses against the wall of a damping hole 32 in its initial position, compressing the internal spring 331 and causing the damping column 332 to move upwards away from the interior of the damping hole 32. As the syringe continues to move, when the damping column 332 reaches the next damping hole 32, the rebound force of the built-in spring 331 causes the hemisphere of the damping column 332 to re-enter the damping hole 32. Therefore, during the process of the experimenter holding the syringe and inserting the injection needle into the mouse's mouth and stomach, the damping column 332 will successively disengage from the damping hole 32 and then re-enter it. Thus, during the process of the experimenter inserting the injection needle into the mouse's stomach, the cooperation of components such as the first clamp 35, the second clamp 36, the damping block 33, and the grooved strip 31 provides support and guidance for the syringe during its advancement. Compared to the existing technology of simply holding the syringe manually, this method ensures the stability of the syringe advancement process. At the same time, the cooperation of components such as the damping column 332 and the damping hole 32 prevents the experimenter from inserting the injection needle too quickly, thereby reducing damage to the mouse and ensuring the safety of the gavage procedure.

[0053] Furthermore, if the syringe is mounted on the first clamp 35 and the second clamp 36, and the injection needle is not properly aligned with the mouse's mouth, or if the insertion angle of the injection needle needs to be adjusted during insertion, the experimenter can apply external force to the grooved strip 31 to cause it to rotate. This indirectly changes the angle between the syringe, the injection needle, and the mouse's mouth, maximizing the fit to the mouse's mouth position and thus improving the flexibility of the auxiliary gavage mechanism. Since the grooved strip 31 and the restraint chamber 24 are tightly connected, the grooved strip 31 will not rotate without external force, and it will not rotate during the experimenter's insertion of the syringe.

[0054] Example 3: Figure 1 , Figure 11 , Figure 12 As shown, a visual quantitative gavage device for laboratory mice also includes a coordination mechanism jointly disposed on the restraint chamber 24 and the placement block 25. The coordination mechanism includes a coaxial plate 41 fixedly connected to the outer wall of a moving shaft 29 away from the placement block 25. Multiple abutments 42 are uniformly fixedly connected to the bottom surface of the coaxial plate 41. Torsion spring pawls 43 are rotatably connected to each of the multiple abutments 42. Specifically, a torsion spring is connected to the part of the torsion spring pawl 43 that is rotatably connected to the abutment 42. The torsion spring is used to realize the automatic rotation and reset of the torsion spring pawl 43. A large gear 44 is rotatably connected to the outer wall of the restraint chamber 24 near the torsion spring pawl 43. The large gear 44 is located on the horizontal movement path of the torsion spring pawl 43. A winding shaft 46 is rotatably connected to the outer wall of the restraint chamber 24 near the large gear 44. A small gear 45 is fixedly connected to one end of the winding shaft 46 near the large gear 44. The small gear 45 meshes with the large gear 44. A half-cylinder 47 is fixedly connected to the outer wall of the restraint chamber 24 away from the winding shaft 46. A second half-cylinder 48 is detachably connected to the side of the half-cylinder 47 away from the restraint chamber 24. Semicircular holes are opened inside both ends of the half-cylinder 47 and the second half-cylinder 48. The two semicircular holes at the same end form a complete circular hole. There are two complete circular holes. A sleeve shaft 49 is inserted between the two circular holes. A cotton roll 410 is sleeved on the outer ring surface of the sleeve shaft 49. The cotton roll 410 is made of cotton cloth wound into a cylindrical shape. The cotton cloth has absorbency. The free end of the cotton roll 410 on the side away from the sleeve shaft 49 passes through the half-tube 47, the restraint chamber 24, and the placement block 25, and one end passing through the three is bonded to the outer ring surface of the take-up shaft 46. Specifically, the half-tube 47, the restraint chamber 24, and the placement block 25 are provided with through grooves for the free end of the cotton roll 410 to pass through, and initially, part of the cotton roll 410 corresponding to the semi-circular arc surface of the placement block 25 is in contact with the semi-circular arc surface.

[0055] Furthermore: such as Figure 12 As shown, a cylindrical rod is provided on the side of the second half-cylinder 48 near the first half-cylinder 47. The first half-cylinder 47 is provided with a hole for the cylindrical rod to be tightly inserted and fitted on the corresponding position. Both the first half-cylinder 47 and the second half-cylinder 48 are made of transparent acrylic material.

[0056] In use: Considering that when experimental mice are restrained between placement block 25 and mating block 26 for gavage, some mice may leave secretions on placement block 25. Therefore, the cotton rolls 410 laid on the semi-circular surface of placement block 25 can effectively absorb the mice's secretions, preventing them from directly adhering to the semi-circular surface of placement block 25 and ensuring the hygiene of the surface of placement block 25 during gavage. In the above embodiment, when the two electromagnets 28 drive the two mating blocks 26 to move horizontally towards each other via their corresponding moving shafts 29, they also drive the torsion spring pawl 43 to move synchronously. During this process, the torsion spring pawl 43 will abut against the teeth of the large gear 44, causing the torsion spring pawl 43 to rotate. The torsion spring deforms under force, and during this process, the torsion spring pawl 43 will not drive the large gear 44 to rotate. After the gavage procedure on the experimental mice is completed, the researchers use a controller to cause the small motor 22 to rotate in the opposite direction, which in turn causes the inclined shaft 21 to rotate 180 degrees in the opposite direction, flipping the restraint chamber 24 and the placement block 25 back to their initial state, so that the experimental mice also return to their initial posture, i.e., the experimental mice face up. Subsequently, the controller de-energizes the two electromagnets 28, and then, under the restoring force of the return spring 210, the two electromagnets 28 slide back along the trajectory of the fixed slot plate 27 to reset, thereby causing the two mating blocks 26 to reset synchronously.

[0057] During the reverse reset of the two mating blocks 26, the torsion spring pawl 43 moves synchronously. During this process, the torsion spring pawl 43, blocked by the abutment plate 42, cannot rotate in the reverse direction. Therefore, the torsion spring pawl 43 drives the large gear 44 to rotate, which in turn drives the small gear 45 to rotate in the opposite direction. Since the radius of the large gear 44 is larger than that of the small gear 45, the transmission ratio between them is large, allowing the small gear 45 to rotate multiple times. The rotation of the small gear 45 then drives the take-up shaft 46 to rotate synchronously, thus completely winding the used cotton cloth onto the outer ring surface of the take-up shaft 46. The take-up shaft 46 automatically winds the used cotton roll 410 onto its outer ring surface and releases the new cotton cloth from the sleeve shaft 49. Therefore, during the gavage procedure on multiple mice, after each mouse has been gavaged, the cotton roll 410, which already contains the secretions of the mice, can be automatically replaced. During the roll-up process, the absorbency of the cotton roll is used to absorb and carry away the secretions of the mice, thus avoiding cross-contamination caused by the secretions sticking together on different mice and reducing the number of manual processing steps.

[0058] Furthermore, after all the experimental mice have undergone gavage, when the used cotton rolls 410 need to be discarded, the experimenter can use a knife to cut off the side of the cotton roll 410 near the take-up shaft 46, and then remove and discard the used cotton roll 410 wrapped around the outer ring surface of the take-up shaft 46. If a new cotton roll 410 needs to be replaced, the experimenter can manually separate half-tube 48 from half-tube 47, separate the sleeve 49 from the semi-circular hole, and then put the new cotton roll 410 onto the sleeve 49. Then, the free end of the cotton roll 410 is passed through the through grooves on half-tube 47, the restraint chamber 24, and the placement block 25, respectively, and the free end of the cotton roll 410 is glued to the outer ring surface of the take-up shaft 46. Finally, half-tube 48 and half-tube 47 are fastened together. Therefore, using half-tube 48 and half-tube 47 not only prevents dust from adhering to the surface of the new cotton roll 410, but the transparent acrylic material also makes it easy for the experimenters to observe the usage of the cotton roll 410 in real time, so that the experimenters can replace it in time, thereby improving the practicality of the cotton roll 410 in the use process.

[0059] The above embodiments are only used to illustrate the technical solutions of the present invention, and are not intended to limit it. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions will not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A visual quantitative gavage device for experimental mice, comprising a fixed base plate (1), characterized in that, The bottom of the fixed bottom plate (1) is uniformly fixedly connected with four suction cups (12), and the top surface center of the fixed bottom plate (1) is fixedly connected with a support frame (11); The upper side of the support frame (11) is provided with a manual restraint mechanism, the manual restraint mechanism comprises an inclined shaft (21) which is rotationally connected to the top of the support frame (11), a small motor (22) is fixedly installed on the upper surface of the side of the support frame (11) close to the inclined shaft (21), the output shaft of the small motor (22) is fixedly connected with the inclined shaft (21), a restraint cabin (24) is fixedly connected on the outer ring surface of the end of the inclined shaft (21) away from the support frame (11), an placing block (25) is fixedly arranged on the inner surface of the side of the restraint cabin (24) away from the support frame (11), the side surface of the placing block (25) away from the restraint cabin (24) is a semicircular surface, two through holes are symmetrically formed in the top of the two sides of the restraint cabin (24), a matching block (26) is inserted into each of the through holes in the top of the two sides of the restraint cabin (24), a quarter of a circular surface is arranged on the bottom surface of each of the two matching blocks (26), a fixed groove plate (27) is fixedly connected to the outer wall of the side of the restraint cabin (24) close to the small motor (22), two electromagnets (28) are slidably connected in the fixed groove plate (27), and initially the two electromagnets (28) are located on the sides away from each other, a movable shaft (29) is fixedly connected to the side of each of the two electromagnets (28) close to the restraint cabin (24), the top end of the movable shaft (29) is fixedly connected with the outer wall of the side of each of the two matching blocks (26) close to each other, a reset spring (210) is fixedly connected between the outer wall of the side of each of the two electromagnets (28) away from the movable shaft (29) and the outer wall of each end of the fixed groove plate (27), two horizontal strips (211) are symmetrically fixedly connected to the outer walls of the two sides of the placing block (25), a fixed cylinder (212) is fixedly connected to the side of each of the two horizontal strips (211) close to each other, an adjusting rod (213) is arranged in the inner part of each end of the two fixed cylinders (212), a supporting groove plate (214) is arranged on the end of the adjusting rod (213) away from the fixed cylinder (212), a U-shaped opening (215) for placing the head of the experimental mouse is arranged on the side of the restraint cabin (24) away from the fixed groove plate (27), a vertical groove plate (216) is fixedly connected to the outer wall of the side of the restraint cabin (24) close to the fixed groove plate (27), the vertical groove plate (216) is provided with vertical groove openings for placing and restraining the tail of the experimental mouse, two straight groove openings (217) are symmetrically formed in the side of the restraint cabin (24) close to the U-shaped opening (215), two threaded rods (218) are symmetrically rotationally connected to the outer wall of the side of the restraint cabin (24) close to the straight groove openings (217), a clamping plate (219) is threadedly connected to each of the two threaded rods (218), the end of each of the two clamping plates (219) away from the threaded rod (218) is located in the inner part of the straight groove opening (217), and a concave strip (23) is fixedly connected between the two clamping plates (219).

2. The visual quantitative gavage device for experimental mice according to claim 1, characterized in that, A quarter of a circular surface is arranged on the bottom surface of each of the two matching blocks (26).

3. The visual quantitative gavage device for experimental mice according to claim 1, characterized in that, The adjusting rod (213) is in threaded connection with the fixed cylinder (212), and the end of the adjusting rod (213) away from the fixed cylinder (212) is in rotational connection with the bracket plate (214).

4. The visual quantitative gavage device for experimental mice according to claim 1, characterized in that, The bracket plate (214) and the vertical groove plate (216) are both made of elastic rubber material, and the vertical groove plate (216) is located at the middle of the constraint cabin (24) close to the fixed groove plate (27).

5. The visual quantitative gavage device for experimental mice according to claim 1, characterized in that, The two clamping plates (219) are both provided with horizontal surfaces and arc surfaces on the sides close to each other, and the horizontal surfaces are above the arc surfaces.

6. The visual quantitative gavage device for experimental mice according to claim 1, characterized in that, An auxiliary gavage mechanism is arranged on the side of the constraint cabin (24) away from the fixed groove plate (27), and the auxiliary gavage mechanism comprises two slotted plate strips (31) rotatably connected to the outer wall of the constraint cabin (24) away from the fixed groove plate (27), the two slotted plate strips (31) are symmetrically distributed on the outer wall of the constraint cabin (24), the positions where the two slotted plate strips (31) are rotatably connected to the constraint cabin (24) are in close fit, a plurality of damping holes (32) are uniformly arranged in the bottoms of the two slotted plate strips (31), damping blocks (33) are slidably connected to the interiors of the ends of the two slotted plate strips (31) away from the constraint cabin (24), holes are arranged in the interiors of the centers of the two damping blocks (33), built-in springs (331) are fixedly connected to the interiors of the holes of the two damping blocks (33), damping columns (332) are fixedly connected to the ends of the built-in springs (331) close to the damping holes (32), the ends of the damping columns (332) away from the built-in springs (331) are hemispherical, the hemispherical positions are initially inserted into the interiors of the damping holes (32), flat rods (34) are fixedly connected to the side surfaces of the two damping blocks (33) close to each other, and a first supporting clamp (35) is fixedly connected to the ends of the flat rods (34) away from the damping blocks (33).

7. The visual quantitative gavage device for experimental mice according to claim 6, characterized in that, The damping blocks (33) are rectangular, and damping grooves are arranged on the slotted plate strips (31) for the sliding displacement of the damping blocks (33).

8. The visual quantitative gavage device for experimental mice according to claim 6, characterized in that, The first supporting clamp (35) and the second supporting clamp (36) are both made of elastic plastic material, the first supporting clamp (35) and the second supporting clamp (36) are both circular rings with notches, and the inner ring surfaces of the first supporting clamp (35) and the second supporting clamp (36) are both provided with anti-skid lines.

9. The visual quantitative gavage device for experimental mice according to claim 1, characterized in that, The cooperation processing mechanism is arranged on the constraint cabin (24) and the placing block (25), and the cooperation processing mechanism comprises a coaxial plate (41) fixedly connected to the outer wall of one dynamic shaft (29) away from the placing block (25), the bottom surface of the coaxial plate (41) is uniformly fixedly connected with a plurality of abutting plates (42), a plurality of torsional spring pawls (43) are rotatably connected to the abutting plates (42), a large gear (44) is rotatably connected to the outer wall of the constraint cabin (24) close to the torsional spring pawls (43), the large gear (44) is located on the horizontal movement path of the torsional spring pawls (43), a winding shaft (46) is rotatably connected to the outer wall of the constraint cabin (24) close to the large gear (44), a small gear (45) is fixedly connected to one end of the winding shaft (46) close to the large gear (44), the small gear (45) and the large gear (44) are mutually engaged, a half cylinder one (47) is fixedly connected to the outer wall of the constraint cabin (24) away from the winding shaft (46), a half cylinder two (48) is detachably connected to the half cylinder one (47) away from the constraint cabin (24), half circle holes are formed in the interiors of two ends of the half cylinder one (47) and the half cylinder two (48), two complete circle holes are formed by the two half circle holes at the same end, a sleeve shaft (49) is inserted between the two circle holes, a cotton roll (410) is sleeved on the outer ring surface of the sleeve shaft (49), the free end of the cotton roll (410) away from the sleeve shaft (49) passes through the half cylinder one (47), the constraint cabin (24) and the placing block (25), and is adhered to the outer ring surface of the winding shaft (46) at one end.

10. The visual quantitative gavage device for experimental mice according to claim 9, characterized in that, The half cylinder two (48) is provided with a cylindrical rod close to the half cylinder one (47), the half cylinder one (47) is provided with a insertion hole corresponding to the cylindrical rod, the half cylinder one (47) and the half cylinder two (48) are made of transparent acrylic material.

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