A postnasal denuder for experimental mice

Abstract

A posterior nasal nerve dissection and retractor for laboratory mice, belonging to the field of medical device technology, solves the technical problem of limited anatomical space and inconvenient instrument operation during posterior nasal nerve resection in laboratory mice. The solution includes clamps, a limiting rack, and a supporting leaf spring. The inner side of the tail of one clamp handle is fixedly connected to one end of the limiting rack. A first locking hole is provided on the inner side of the tail of the other clamp handle, and the other end of the limiting rack is movably inserted into the first locking hole. The supporting leaf spring is cross-arranged within the area enclosed by the clamp handles and the limiting rack on both sides. Symmetrical light guide grooves are provided between the opposing surfaces of the two clamp heads, and symmetrical grooves are provided between the opposing surfaces of the outer ends of the two clamp heads. A dissector and a retractor are detachably installed in the grooves on both sides, respectively. A protective plate is detachably installed on the outer surface of the clamp head near the retractor. This invention provides a new tool for establishing a stable and reliable experimental mouse model of posterior nasal nerve resection.

Description

Technical Field

[0001] This utility model belongs to the field of medical device technology, specifically relating to a nasal nerve dissection and dispersant for experimental mice. Background Technology

[0002] Allergic rhinitis is a chronic inflammatory disease with a high incidence and serious harm. Its pathogenesis is not limited to abnormal immune system responses but also involves neuroimmunological mechanisms. Recent studies have found that the pathogenesis of allergic rhinitis is closely related to the "nasobrain axis," that is, the interaction and regulation between the nasal cavity and the central nervous system is achieved through the neuroimmune system. Therefore, posterior nasal nerve resection is not only an effective treatment for moderate to severe allergic rhinitis, but also of great significance in studying the neuroimmunological mechanisms of the "nasobrain axis." By establishing an animal model of posterior nasal nerve resection, this mechanism can be explored in depth, providing new ideas and support for basic research and clinical treatment of allergic rhinitis.

[0003] The application of existing surgical tools in posterior nasal nerve resection in experimental mice has significant limitations, mainly including the following problems:

[0004] (1) The instruments are large in size, making it difficult to accurately locate the posterior nasal nerve when operating on small experimental animals such as experimental mice, resulting in an excessively large cutting range or incomplete blockage. The positioning deviation during the operation makes it difficult to ensure the reliability of the experimental results.

[0005] (2) The anatomical area of ​​the posterior nasal region is narrow and the field of vision is limited. During the operation, it is easy to damage the surrounding tissues, especially the eye structure, causing unnecessary damage. Moreover, it is very easy to bleed, and it is difficult to stop the bleeding effectively, which will increase the difficulty of the operation and affect the accuracy of the experimental results.

[0006] Based on the above problems, there is an urgent need to develop a surgical instrument for posterior nasal nerve resection in laboratory mice. Utility Model Content

[0007] The main purpose of this invention is to overcome the shortcomings of the prior art and solve the technical problems of narrow anatomical space and limited field of vision, large instrument size and unreliable blocking effect in the posterior nasal nerve resection of experimental mice. This invention provides a posterior nasal nerve dissection and retractor for experimental mice.

[0008] This utility model is achieved through the following technical solution: a retronasal nerve dissection and retractor for experimental mice, comprising clamps, a limiting rack, and supporting leaf springs. The supporting leaf springs include a first supporting leaf spring and a second supporting leaf spring. The clamps include clamp heads and clamp handles. The clamp heads are fixedly installed at the front end of the clamp handles. The clamp heads and the middle parts of the clamp handles on both sides are X-shaped, overlapping and hinged to each other.

[0009] At the position of the clamp handle:

[0010] The inner side of the tail of the pliers handle on one side is fixedly connected to one end of the limiting rack, and the inner side of the tail of the pliers handle on the other side is provided with a first locking hole, and the other end of the limiting rack is movably inserted into the first locking hole;

[0011] The tail of the first support leaf spring is fixedly connected to the tail of the pliers handle on one side, and the tail of the second support leaf spring is fixedly connected to the tail of the pliers handle on the other side. The first support leaf spring and the second support leaf spring are arranged opposite to each other, and both the first support leaf spring and the second support leaf spring are located inside the fixed end of the limiting rack. A second locking hole is provided at the free end of the second support leaf spring, and the free end of the first support leaf spring is movably inserted into the second locking hole.

[0012] At the position of the clamp head:

[0013] A V-shaped light guide groove is symmetrically arranged between the opposing surfaces of the two clamp heads, and grooves are symmetrically arranged between the opposing surfaces of the outer ends of the two clamp heads. A peeler is detachably installed in the groove on one side, and a spreader is detachably installed in the groove on the other side.

[0014] A protective plate is detachably installed on the outer side of the pliers near the side of the spreader.

[0015] Furthermore, the material of the peeler and the forceps head near the peeler is transparent PMMA, and the material of the spreader is medical titanium alloy.

[0016] Furthermore, the clamp head and the protective plate are detachably connected via a magnet array.

[0017] Furthermore, the protective panel is made of medical-grade light-shielding PC board.

[0018] Furthermore, the peeler, the spreader, and the corresponding clamps are detachably connected by bolts.

[0019] Furthermore, the surface of the peeler is frosted (to reduce reflection), the side edge of the peeler is marked with scale marks, the working end of the peeler is blunt and shovel-shaped, and gradually thickens from the end to the root.

[0020] Furthermore, the spreader includes a rod body, and from top to bottom, a return hook body and a curved hook body are arranged at the lower end of the rod body. The end of the curved hook body is set as a ball head (that is, the end of the curved hook body is blunted and rounded). The radius of curvature of the return hook body is 1.5mm and the central angle is 30°; the radius of curvature of the curved hook body is 4mm and the central angle is 110°.

[0021] The beneficial effects of this utility model are as follows:

[0022] This invention comprises a dissector, a retractor, an opening fixation device (limiting rack and supporting leaf spring), and a protective plate. Through optimized structural design, it provides a wider field of vision and more precise positioning during surgery. This device allows for effective dissection, fixation, and severing of the posterior nasal nerve within narrow spaces, avoiding unnecessary tissue damage, reducing the risk of bleeding, and improving surgical success rates. It provides a new tool for establishing a stable and reliable mouse model of posterior nasal nerve severance, laying the foundation for further exploration of the pathological mechanisms and treatment methods of allergic rhinitis. Attached Figure Description

[0023] Figure 1 This is a three-dimensional structural diagram of the present invention;

[0024] Figure 2 This is a three-dimensional structural diagram of the present invention with the protective plate omitted.

[0025] Figure 3 This is a rear-view 3D structural diagram of the protective panel;

[0026] Figure 4 This is a front-view three-dimensional structural diagram of the peeling unit;

[0027] Figure 5 This is a front view three-dimensional structural diagram of the expander.

[0028] In the diagram, 1 is the clamp, 1-1 is the clamp head, 1-2 is the clamp handle, 2 is the limiting rack, 3 is the support leaf spring, 3-1 is the first support leaf spring, 3-2 is the second support leaf spring, 4 is the peeler, 5 is the spreader, 5-1 is the rod, 5-2 is the return hook body, 5-3 is the curved hook body, 6 is the protective plate, 7 is the magnet array, and 8 is the bolt. Detailed Implementation

[0029] The present invention will now be described in further detail with reference to the accompanying drawings and embodiments.

[0030] like Figures 1 to 5 The diagram shows a retronasal nerve dissection and retractor for experimental mice, comprising clamps 1, a limiting rack 2, and supporting leaf springs 3. The supporting leaf springs include a first supporting leaf spring 3-1 and a second supporting leaf spring 3-2. The clamps 1 include clamp heads 1-1 and clamp handles 1-2. In this specific embodiment, the length of the clamp head 1-1 is 6 cm, and the length of the clamp handle 1-2 is 12 cm. The clamp head 1-1 is fixedly installed at the front end of the clamp handle 1-2. The middle portions of the two clamp heads 1-1 and clamp handles 1-2 are arranged in an X-shape and hinged to each other. The characteristic feature is that:

[0031] At position 1-2 of the clamp handle:

[0032] The inner side of the tail of the pliers 1-2 on one side is fixedly connected to one end of the limiting rack 2, and the inner side of the tail of the pliers 1-2 on the other side is provided with a first locking hole, and the other end of the limiting rack 2 is movably inserted into the first locking hole;

[0033] The tail of the first support leaf spring 3-1 is fixedly connected to the tail of either side of the plier handle 1-2, and the tail of the second support leaf spring 3-2 is fixedly connected to the tail of the other side of the plier handle 1-2. The first support leaf spring 3-1 and the second support leaf spring 3-2 are arranged opposite to each other, and both the first support leaf spring 3-1 and the second support leaf spring 3-2 are located inside the fixed end of the limiting rack 2. A second locking hole is provided at the free end of the second support leaf spring 3-2, and the free end of the first support leaf spring 3-1 is movably inserted into the second locking hole.

[0034] At position 1-1 of the clamp head:

[0035] A V-shaped light guide groove is symmetrically arranged between the opposing surfaces of the forceps heads 1-1 on both sides. In this embodiment, the light guide groove is 30mm long, 0.2mm deep, and 0.5mm wide. A groove is symmetrically arranged between the opposing surfaces of the outer ends of the forceps heads 1-1 on both sides. A dissector 4 is detachably installed in the groove on one side. The dissector 4 is made of transparent PMMA material, and the forceps head 1-1 on the side closest to the dissector 4 is also made of transparent PMMA material. During posterior nasal nerve dissection or retraction in mice, the light source can illuminate the field of view through the forceps head 1-1, the V-shaped light guide groove, and the dissector 4. A retractor 5 is detachably installed in the groove on the other side. The retractor 5 is made of medical-grade titanium alloy. The dissector 4, the retractor 5, and the corresponding forceps head 1-1 are detachably connected by bolts 8.

[0036] A protective plate 6 is detachably mounted on the outer surface of the forceps head 1-1 near the spreader 5. The protective plate 6 is made of medical light-shielding PC board. In this embodiment, a magnetic ring with a diameter of 2mm and a thickness of 1mm is fixedly mounted at 25mm, 35mm and 45mm from the end of the forceps head 1-1, forming a straight-line magnetic array 7. A corresponding straight-line magnetic array 7 is also mounted on the side edge of the protective plate 6. The forceps head 1-1 and the protective plate 6 are detachably connected through the magnetic array 7.

[0037] In this embodiment, the peeler 4 is 20mm long and 3mm wide. The surface of the peeler 4 is frosted (to reduce reflection). The side edge of the peeler 4 is marked with scale marks, with a line every 1mm. The working end of the peeler 4 is blunt and shovel-shaped, and gradually thickens from the end to the root (0.8mm at the thickest point).

[0038] In this embodiment, the spreader 5 includes a rod 5-1. From top to bottom, the lower end of the rod 5-1 is provided with a return hook 5-2 and a curved hook 5-3. The end of the curved hook 5-3 is set as a ball head (i.e., the end of the curved hook is blunted and rounded, with a ball head diameter of 0.3mm). The radius of curvature of the return hook 5-2 is 1.5mm, and the central angle is 30°. The radius of curvature of the curved hook 5-3 is 4mm, and the central angle is 110°. In this embodiment, the diameter of the rod 5-1 is 2mm, and the length is 15mm.

[0039] In this embodiment, the protective plate 6 is made of amber-colored PC board with a matte finish, and its dimensions are: length 40mm × width 20mm × thickness 1mm.

[0040] The usage process of this utility model is as follows:

[0041] Preparation before use: Determine the flexibility of the support leaf spring 3 (open and close 3 times, check for rebound); check for any tissue residue at the double-sided clamp heads 1-1 and install the peeler 4 and the spreader 5; verify the adsorption force between the protective plate 6 and the magnet array 7 (vertical tension > 0.5N).

[0042] Intraoperative procedure: A longitudinal incision is made between the upper eyelid and the supraorbital crest of the experimental mouse. The tissue is bluntly dissected until the frontal bone is exposed. Holding forceps handles 1-2 in the left hand, with one side of the dissector 4 below and the other side of the retractor 5 above, the forceps are moved downwards along the bone surface. The dissector 4 is used to dissect and protect the underlying periorbital tissues and maxillary nerve, etc., until the bottom of the bone surface is reached. The upper scale of the dissector 4 is read, and the depth of entry is recorded. The retractor 5 is held against the upper bone surface. The forceps handles 1-2 are pressed inwards with the left hand to compress the limiting rack 2. Once the posterior nasal foramen and the posterior nasal nerve passing through it are exposed at the bottom of the bone surface, and its location is confirmed to be ventral below the anterior ethmoidal foramen, instruments (bipolar, heating pen, etc.) can be inserted through the gap between the dissector 4 and the retractor 5 to manage the nerves and blood vessels within the posterior nasal foramen. After the operation is completed, the limiting rack 2 is removed while remaining in place.

[0043] Post-use processing: Remove the peeler 4, the spreader 5, and the protective plate 5; clean the blood stains on the instruments; and individually package and autoclave.

[0044] The above description is merely a specific embodiment of this utility model, but the protection scope of this utility model is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in this utility model should be included within the protection scope of this utility model. Therefore, the protection scope of this utility model should be determined by the protection scope of the claims.

Claims

1. A nasal nerve dissection and retractor for experimental rats, comprising clamps (1), a limiting rack (2), and a supporting leaf spring (3), the supporting leaf spring comprising a first supporting leaf spring (3-1) and a second supporting leaf spring (3-2), the clamps (1) comprising clamp heads (1-1) and clamp handles (1-2), the clamp heads (1-1) being fixedly mounted on the front end of the clamp handles (1-2), the clamp heads (1-1) and the clamp handles (1-2) on both sides being X-shapedly crossed and hinged to each other, characterized in that: At the position of the clamp handle (1-2): The inner side of the tail of the pliers handle (1-2) on one side is fixedly connected to one end of the limiting rack (2), and the inner side of the tail of the pliers handle (1-2) on the other side is provided with a first locking hole, and the other end of the limiting rack (2) is movably inserted into the first locking hole; The tail of the first support leaf spring (3-1) is fixedly connected to the tail of the pliers (1-2) on one side, and the tail of the second support leaf spring (3-2) is fixedly connected to the tail of the pliers (1-2) on the other side. The first support leaf spring (3-1) and the second support leaf spring (3-2) are arranged opposite to each other, and both the first support leaf spring (3-1) and the second support leaf spring (3-2) are located inside the fixed end of the limiting rack (2). A second locking hole is provided at the free end of the second support leaf spring (3-2), and the free end of the first support leaf spring (3-1) is movably inserted into the second locking hole. At the position of the clamp head (1-1): A V-shaped light guide groove is symmetrically arranged between the opposing surfaces of the two clamp heads (1-1), and grooves are symmetrically arranged between the opposing surfaces of the outer ends of the two clamp heads (1-1). A peeler (4) is detachably installed in the groove on one side, and a spreader (5) is detachably installed in the groove on the other side. A protective plate (6) is detachably provided on the outer surface of the pliers (1-1) near the side of the spreader (5).

2. The experimental rat nasal nerve dissection and retractor according to claim 1, characterized in that: The material of the peeler (4) and the forceps (1-1) on the side near the peeler (4) is transparent PMMA, and the material of the spreader (5) is medical titanium alloy.

3. The experimental rat nasal nerve dissection and retractor according to claim 1, characterized in that: The clamp head (1-1) and the protective plate (6) are detachably connected by a magnet array (7).

4. A retronasal nerve dissection and retractor for experimental mice according to claim 1 or 3, characterized in that: The protective plate (6) is made of medical-grade light-shielding PC board.

5. The experimental rat nasal nerve dissection and retractor according to claim 1, characterized in that: The peeler (4), the spreader (5), and the corresponding clamps (1-1) are detachably connected by bolts (8).

6. A retronasal nerve dissection and retractor for experimental mice according to claim 1 or 5, characterized in that: The surface of the peeler (4) is sanded, and scale marks are set on the side edge of the peeler (4). The working end of the peeler (4) is set as a blunt head and a shovel-shaped end, and gradually thickens from the end to the root.

7. A retronasal nerve dissection and retractor for experimental mice according to claim 1 or 5, characterized in that: The spreader (5) includes a rod (5-1), and the lower end of the rod (5-1) is provided with a return hook body (5-2) and a curved hook body (5-3) from top to bottom. The end of the curved hook body (5-3) is set as a ball head. The radius of curvature of the return hook body (5-2) is 1.5mm and the central angle is 30°. The radius of curvature of the curved hook body (5-3) is 4mm and the central angle is 110°.

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