Low-irritation composition and low-irritation hand sanitizer containing same

Abstract

The invention relates to a daily chemical product, in particular to a low-irritation composition and a low-irritation hand sanitizer containing the same. The invention aims to provide a low-irritation composition and a low-irritation hand sanitizer containing the composition. The composition and the low-irritation hand sanitizer containing the composition have the characteristics of low irritation to human skin and simple and convenient preparation process. According to the technical scheme, the low-irritation composition is prepared from the following components: a, 20 to 30 weight percent of PEG-7 (Polyethylene Glycol-7) glyceryl cocoate; b. 10 wt% to 20 wt% of lactic acid; c. From 10 wt% to 20 wt% of sophorolipid; d, a pH regulator; e, the balance of pure water; the pH (Potential of Hydrogen) value of the composition is 3.0 to 5.0.

Description

TECHNICAL FIELD

[0001] The present application relates to a daily chemical product, in particular to a low-irritation composition and a low-irritation hand sanitizer containing the same. BACKGROUND

[0002] Due to cost constraints, most of the existing commercially available hand sanitizer products use anionic surfactants, such as sodium dodecyl benzene sulfonate (LAS), sodium C10-16 alcohol polyoxyethylene ether sulfate (AES), etc. Although these surfactants have good detergency and very high cost performance, they can easily cause skin irritation and may cause dryness or allergic reactions. Therefore, how to develop a low-irritation hand sanitizer has become a problem to be solved in the field of washing product technology. SUMMARY

[0003] The purpose of the present application is to overcome the shortcomings of the background art, and to provide a low-irritation composition and a low-irritation hand sanitizer containing the same, which has the characteristics of low irritation to human skin and simple and convenient manufacturing process.

[0004] The technical solution provided by the present application is:

[0005] A low-irritation composition, comprising the following components:

[0006] a. 20wt%-30wt% of PEG-7 glyceryl cocoate;

[0007] b. 10wt%-20wt% of lactic acid;

[0008] c. 10wt%-20wt% of sophorolipid;

[0009] d. pH adjuster;

[0010] e. the rest is pure water;

[0011] The pH value of the composition is 3.0-5.0.

[0012] The lactic acid is L-lactic acid, and the structural formula is as follows:

[0013]

[0014] The sophorolipid is acid type, lactone type or a mixture of the two in any ratio;

[0015] The structural formula of the acid sophorolipid is as follows:

[0016]

[0017] The structural formula of the lactone sophorolipid is as follows:

[0018]

[0019] The pH regulator is at least one of sodium hydroxide, potassium hydroxide, triethanolamine, and monoethanolamine.

[0020] The low-irritation hand sanitizer containing the low-irritation composition is characterized in comprising the following components:

[0021] a. 7wt% to 10wt% of C10-16 alcohol polyoxyethylene ether sulfate sodium (AES);

[0022] b. 2wt% to 4wt% of cocamide propyl betaine (CAB);

[0023] c. 0.1wt% to 0.5wt% of a chelating agent;

[0024] d. 5wt% to 10wt% of the low-irritation composition;

[0025] e. a preservative;

[0026] f. a pH regulator;

[0027] g. an appropriate amount of fragrance;

[0028] h. the rest is pure water;

[0029] The pH value of the low-irritation hand sanitizer is 4.0-6.0.

[0030] The chelating agent is at least one of ethylenediaminetetraacetate, diethylenetriamine pentaacetate, methyl glycine diacetate, glutamic acid diacetate tetrasodium (GLDA-4Na), and sodium citrate dihydrate.

[0031] The preservative is at least one of methyl isothiazolinone, phenoxyethanol, sodium benzoate, and methyl chloroisothiazolinone.

[0032] The pH regulator is at least one of sodium hydroxide, potassium hydroxide, triethanolamine, and monoethanolamine.

[0033] The fragrance is a daily-use fragrance, belonging to Category 9 of GB / T 22731 Daily-Use Fragrance. DETAILED DESCRIPTION

[0034] The embodiments of the present application are described in detail below. Unless otherwise specified, the raw materials and equipment used are commercially available or commonly used in the art. The methods in the embodiments are conventional methods in the art, unless otherwise specified.

[0035] Examples 1-2

[0036] Examples 1 and 2 provide a low-irritant composition and its preparation method, wherein the weight percentage of each component of the low-irritant composition is shown in Table 1.

[0037] The preparation method is as follows: add pure water, PEG-7, lactic acid and sophorolipid to the main reaction vessel, stir thoroughly until the raw materials are completely dissolved, and control the pH value of the solution to 3.0-5.0.

[0038] Table 1 Examples of Low-Irritation Compositions

[0039]

[0040] Examples 3-5

[0041] Examples 3-5 provide a low-irritant hand sanitizer and its preparation method, wherein the weight percentage of each component of the low-irritant hand sanitizer is shown in Table 2.

[0042] The preparation method is as follows:

[0043] S1. Add pure water and chelating agent to the main reactor, start stirring, and add AES and CAB. Stir thoroughly until the raw materials are completely dissolved, and control the pH of the solution to be neutral.

[0044] S2. Add the composition of Examples 1 and 2, Kathon, and flavoring, and stir thoroughly until the raw materials are completely dissolved, controlling the pH of the solution to 4-6.

[0045] Table 2. Case studies of low-irritation hand sanitizer implementation.

[0046]

[0047]

[0048] Sample testing:

[0049] Irritation test: Zein method

[0050] Prepare a 1% (w / w) aqueous solution of the active ingredient. Take 30 mL of this solution, add 1–1.5 g of excess Zein, stir at room temperature for 120 minutes, and filter. Transfer 5 mL of the filtrate to a Kjeldahl flask, add 0.2 g of copper sulfate, 2.5 g of potassium sulfate, and 10 mL of concentrated sulfuric acid. Nitrate in a nitrification furnace for 60 minutes until a clear, light blue liquid appears. Alkaline distillation is performed using a 40% (w / w) NaOH solution in a Kjeldahl nitrogen analyzer, and the sample is titrated with standardized hydrochloric acid.

[0051] An aqueous solution of surfactant without Zein and containing 1% active ingredient by mass was used as a blank control.

[0052] The nitrogen content of the sample is calculated using the following formula:

[0053]

[0054] wherein:

[0055] X* is the nitrogen content in the sample;

[0056] V1 is the volume of hydrochloric acid consumed by the sample, mL;

[0057] V0 is the volume of hydrochloric acid consumed by the blank, mL;

[0058] C is the concentration of the hydrochloric acid standard solution, mol / L;

[0059] 0.014 is the number of grams of nitrogen corresponding to 1 mL of 1 mol / L hydrochloric acid standard solution;

[0060] V 样品 is the sampling volume of the sample, mL.

[0061] The zein value of the sample is calculated according to the following formula, which is used as a standard for evaluating the irritation of the sample, and the greater the zein value, the stronger the irritation and delipidation ability of the sample on the skin.

[0062]

[0063] wherein:

[0064] X1* is the nitrogen content measured without alcohol-soluble protein;

[0065] X2* is the nitrogen content measured with alcohol-soluble protein;

[0066] V1 is the volume of hydrochloric acid consumed by the sample without alcohol-soluble protein, mL;

[0067] V2 is the volume of hydrochloric acid consumed by the sample with alcohol-soluble protein, mL;

[0068] C is the concentration of the hydrochloric acid standard solution, mol / L;

[0069] 0.014 is the number of grams of nitrogen corresponding to 1 mL of 1 mol / L hydrochloric acid standard solution;

[0070] V 样品 is the sampling volume of the sample, mL.

[0071] Test Results

[0072] Table 3 Example Irritation Results

[0073] Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 zein value 0.08 0.03 0.37 0.25 0.76 1.56 Evaluation Low irritancy Low irritancy Low irritancy Low irritancy Medium irritancy Strong irritancy

[0074] Table 4 Irritation Results Evaluation

[0075] zein value Irritancy classification ＜0.5 Low irritancy 0.5～1.5 Medium irritancy ＞1.5 Strong irritancy

[0076] From the irritant results of the examples in Table 3, it can be seen that Example 6, which did not add the composition, was strongly irritating. Example 5, which added less than the specified amount of the composition, was less irritating, but was still moderately irritating. Examples 3 and 4, which added the composition, were within the low irritation range, demonstrating the feasibility of the application.

[0077] The specific embodiments described herein merely illustrate the application. The application is not limited to these specific embodiments and any modification made to the embodiments without departing from the spirit and scope of the application will be considered to fall within the scope of the application.

Claims

1. A low-irritation composition characterized in that: It comprises the following components: a. 20wt% to 30wt% of PEG-7 glyceryl cocoate; b. 10wt% to 20wt% of lactic acid; c. 10wt% to 20wt% of sophorolipid; d. pH regulator; e. the rest is pure water; The pH value of the composition is 3.0-4.

0.

2. The low-irritation composition according to claim 1, characterized in that: The lactic acid is L-lactic acid, and its structural formula is as follows:

3. The composition of claim 2, wherein: The sophorolipid is acid type, lactone type or a mixture of both in any ratio; The structural formula of the acid type sophorolipid is as follows: The structural formula of the lactone type sophorolipid is as follows 4. The composition of claim 3, wherein: The pH regulator is at least one of sodium hydroxide, potassium hydroxide, triethanolamine, and monoethanolamine.

5. A low-irritation hand sanitizer comprising the composition of claim 1, characterized in that: It comprises the following components: a. 7wt% to 10wt% of sodium C10-16 alcohol polyoxyethylene ether sulfate; b. 2wt% to 4wt% of cocamidopropyl betaine; c. 0.1wt% to 0.5wt% of chelating agent; d. 5wt% to 10wt% of the composition of claim 1; e. an appropriate amount of preservative; f. an appropriate amount of pH regulator; g. an appropriate amount of essence; h. the rest is pure water; The pH value of the low-irritation hand sanitizer is 4.0-6.

0.

6. The low-irritation hand sanitizer of claim 5, wherein: The chelating agent is at least one of ethylenediaminetetraacetate, diethylenetriamine pentaacetate, methyl glycine diacetate, glutamic acid diacetate, and sodium citrate dihydrate.

7. The low-irritation hand sanitizer according to claim 6, wherein The preservative is at least one of methyl isothiazolinone, phenoxyethanol, sodium benzoate, and methyl chloroisothiazolinone.

8. The low-irritation hand sanitizer of claim 7, wherein, The pH regulator is at least one of sodium hydroxide, potassium hydroxide, triethanolamine, and monoethanolamine.

9. The low-irritation hand sanitizer of claim 8, wherein, The essence is a daily-use essence.

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