Application of exosome blocker in treatment of sleep disorder

By using miR-24 blockers such as GW4869 to inhibit the production or secretion of miR-24, the shortcomings of traditional methods for treating sleep disorders have been overcome, enabling safe and effective improvement of hypoxia-induced sleep disorders and providing a new treatment strategy.

CN121466079APending Publication Date: 2026-02-06ACADEMY OF MILITARY MEDICAL SCIENCES
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Patent Information

Application Number
CN202511656574.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-11-12
Publication Date
2026-02-06

AI Technical Summary

Technical Problem

Traditional treatments for sleep disorders suffer from drug dependence, significant side effects, short-lived efficacy, and inability to fundamentally address nerve damage. There is an urgent need to develop new treatment options that are safe and free of toxic side effects.

Method used

miR-24 blockers, including substances that inhibit the production, secretion, maturation, or interaction of miR-24 with target cells, such as GW4869, are used to prepare drugs for treating hypoxia-induced sleep disorders. The expression or activity of the miR-24 gene or protein is detected by screening methods to select candidate drugs.

Benefits of technology

Inhibiting miR-24 secretion significantly improved the reduction in total sleep and daytime sleep duration and sleep fragmentation induced by hypoxia stress, providing a new intervention strategy with broad application prospects.

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Abstract

The invention discloses an application of an exosome blocker in treatment of sleep disorders. It is found for the first time that after miR-24 secretory expression is inhibited, the hypoxia stress induced total sleep and daytime sleep duration reduction and sleep fragmentation phenomena are obviously improved. A new intervention strategy is provided for coping with sleep disorder caused by environmental stress, and the application prospect is wide.
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