Selective activation leukocyte adsorber with flow guide net

Abstract

The invention belongs to the field of medical blood purification instruments, and discloses a selective activated leukocyte adsorber, which is used for solving the problems that a film layer of an existing adsorber is easy to deform, the blood flow is uneven, the activated leukocyte adsorption efficiency is low and the assembly safety is poor. According to the adsorber, a three-layer preassembly is formed by a flow guide net and a selective activated leukocyte adsorption film, wherein the thickness of the flow guide net is matched with the mesh diameter of a blood cell amoeba motion; a cylindrical winding body containing a radial repeated circulation unit is formed by clamping and winding the core rod I and the core rod II in a non-adhesive mode, and the cylindrical winding body is matched with a multi-blood input / output pipeline extending in the axial direction and is packaged through a shell with a sealing end cover and a sealing ring. The flow guide net can support the membrane layer, guide blood to be uniformly distributed, construct a cell microcirculation environment and improve the adsorption efficiency; the double-core-rod glue-free fixing and shell sealing design ensures the assembly safety and the structural stability, and is suitable for selectively removing activated white blood cells in clinical blood purification and assisting in treatment of inflammation-related diseases.

Description

Technical Field

[0001] This invention relates to the field of medical blood purification equipment technology, specifically to a selectively activated leukocyte adsorbent with a flow guide mesh. Background Technology

[0002] In clinical blood purification therapy, selectively removing activated leukocytes from the blood is one of the key methods to alleviate the inflammatory response. Existing selectively activated leukocyte adsorbents typically involve directly winding a selectively activated leukocyte adsorption membrane to form an adsorption unit, but this method has the following drawbacks: 1. The adsorption membrane lacks a supporting structure and is prone to deformation and wrinkling after being rolled up, resulting in insufficient contact between blood and the membrane surface; 2. When blood flows directly through the adsorption membrane, the distribution is uneven, the local blood flow is too fast or stagnant, and the binding efficiency of activated leukocytes to the membrane is low. 3. Blood cells cannot form an orderly movement environment on the membrane surface, making it difficult for them to fully contact the adsorption sites on the membrane surface through amoeba movement; 4. During the winding process, the adsorption membrane and the core rod are often fixed with glue, which not only makes the assembly operation cumbersome, but may also introduce chemical contaminants and increase the risk of clinical use. Summary of the Invention

[0003] To address the shortcomings of existing technologies, the present invention aims to provide a selectively activated leukocyte adsorbent. By adding a flow guide net, it achieves the functions of support, flow guidance, and the creation of a microcirculation environment, thereby improving the removal efficiency of activated leukocytes. At the same time, the use of a core rod clamping to replace glue bonding simplifies assembly and improves safety in use.

[0004] To solve the above-mentioned technical problems, the present invention adopts the following solution: A flow guide net coupled to a selectively activated leukocyte adsorption membrane is disclosed. The flow guide net is attached to the surface of the selectively activated leukocyte adsorption membrane and can be wound synchronously with the membrane. The thickness of the flow guide net is adapted to the amoeboid movement requirements of blood cells. The flow guide net has multiple mesh openings, the pore size of which is adapted to the amoeboid movement requirements of blood cells, allowing blood cells to crawl and move through the mesh openings, thereby forming a microcirculatory environment on the surface of the activated leukocyte adsorption membrane and promoting the contact and adsorption of activated leukocytes with the membrane.

[0005] This guide net, through its adhesive coupling and synchronous winding with the adsorption membrane, provides support for the adsorption membrane layer and, with a thickness and mesh size adapted to the movement of blood cell amoebae, guides blood cells to actively crawl and form microcirculation. This addresses the pain points of existing adsorbers, such as lack of support leading to deformation, uneven blood flow, and low utilization of adsorption sites. Existing technologies do not involve the design of a "guide net adapted to the movement of blood cell amoebae." This solution integrates support, guidance, and microcirculation construction functions, breaking through the traditional passive adsorption logic and significantly improving the removal efficiency of activated leukocytes, demonstrating outstanding substantive features and significant progress.

[0006] A further preferred technical solution is that the thickness of the guide net is 0.05mm-0.33mm, and the mesh size is 0.07mm-0.42mm.

[0007] The thickness and mesh pore size range are precisely matched to the spatial and traversal requirements of amoeba movement in blood cells, ensuring that cells actively crawl to form microcirculation while also taking into account the support strength of the flow guide mesh and the smoothness of blood flow. This further improves adsorption efficiency and structural stability, representing a targeted optimization of core technical features and enhancing the practicality of the solution.

[0008] A further preferred technical solution is that the width of the ribs between two adjacent mesh openings is 0.05mm-2mm, and the center-to-center distance between the mesh openings is 0.075mm-0.62mm.

[0009] The design of the rib width and the center-to-center spacing of the mesh ensures both the structural strength of the flow guide and the uniform distribution of the mesh, providing a dense and orderly passage path for the movement of blood cells and amoebae. This avoids blood flow disturbance caused by excessively wide ribs obscuring the surface of the adsorption membrane or excessively large spacing, further optimizing the synergistic effect of the microcirculation environment and adsorption efficiency.

[0010] A selectively activated leukocyte adsorbent includes a flow guide net and a selectively activated leukocyte adsorption membrane; the flow guide net includes an upper flow guide net and a lower flow guide net, which are respectively tightly attached to the upper and lower surfaces of the selectively activated leukocyte adsorption membrane to form a three-layer pre-assembled body in a rectangular planar shape; the three-layer pre-assembled body is wound to form a cylindrical wound body; The cylindrical winding body includes multiple repeating flow units, which are connected sequentially along the radial direction of the cylindrical winding body. Each repeating flow unit includes, from the inside to the outside, a first guide mesh layer, a first blood flow channel, a selectively activated leukocyte adsorption membrane layer, a second blood flow channel, and a second guide mesh layer. The two axial end faces of the cylindrical winding body are a blood inlet end face and a blood outlet end face, respectively. A blood input channel is provided at the blood inlet end face, and a blood output channel is provided at the blood outlet end face. The blood flow path is as follows: Blood enters the cylindrical coil from the blood inlet end face through the blood input channel and flows radially into the first blood flow channel and the second blood flow channel of each repeating flow unit; within the blood flow channel, the blood comes into full contact with the surface of the selectively activated leukocyte adsorption membrane layer, and the activated leukocytes in the blood are selectively adsorbed by the selectively activated leukocyte adsorption membrane layer; the blood cells that are not adsorbed complete the crawling displacement and pass through the first or second guide mesh layer by means of the mesh pores adapted to the amoeboid movement of blood cells in the guide mesh layer, thereby forming a microcirculatory environment on the surface of the selectively activated leukocyte adsorption membrane layer, promoting the contact and adsorption of activated leukocytes with the selectively activated leukocyte adsorption membrane layer.

[0011] This adsorber forms a three-layer pre-assembled structure by sandwiching an adsorption membrane between upper and lower guide nets. After winding, it constitutes a cylindrical coil containing repeating flow units, achieving orderly blood flow in conjunction with axial blood inlet / outlet channels. The core innovation lies in coupling the guide net with the coiled structure. The guide net provides support for the membrane layer and guides the blood to distribute evenly. Furthermore, its mesh, adapted to amoeba movement, allows blood cells to actively crawl and form microcirculation, completely solving the pain points of existing adsorbers such as lack of support leading to deformation, uneven blood flow, and low utilization of adsorption sites. This solution integrates support, guidance, and high-efficiency adsorption functions, breaking through the traditional passive adsorption logic and significantly improving the removal efficiency of activated leukocytes, demonstrating outstanding substantive features and significant progress.

[0012] A further preferred technical solution is that the blood input channel comprises multiple blood input pipes, which extend along the axial direction of the cylindrical winding body and are correspondingly disposed within the first blood flow channel and the second blood flow channel of each repeating flow unit; the blood output channel comprises multiple blood output pipes, which extend along the axial direction of the cylindrical winding body and are correspondingly disposed within the first blood flow channel and the second blood flow channel of each repeating flow unit.

[0013] This preferred design employs a precise matching design of "multiple channels corresponding to multiple blood flow pathways," refining the blood input / output channels into multiple channels extending axially along the cylindrical coil. Each repeating flow unit has its first and second blood flow channels configured with dedicated input / output channels. Its core value lies in two aspects: firstly, overcoming the problem of uneven radial blood distribution caused by traditional single inlet / outlet systems, allowing blood to be delivered directly and evenly to each blood flow channel; secondly, the dedicated output channels can promptly remove adsorbed blood, reducing retention and backflow within the channels. This synergizes with the microcirculation guidance function of the flow guide net, ensuring "macroscopic uniform distribution" through the channels and achieving "microscopic active crawling" through the flow guide net. This dual effect further enhances the contact efficiency between blood and the adsorption membrane.

[0014] A further preferred technical solution includes a mandrel, which includes mandrel I and mandrel II arranged opposite to each other, with the three-layer pre-assembled body sandwiched in the middle, and the three-layer pre-assembled body being wound along the axis of the mandrel.

[0015] This preferred design, through the "three-layer pre-assembly sandwiched between mandrels I and II positioned opposite each other," provides a stable benchmark for winding and forming. Simultaneously, winding along the mandrel axis ensures that the three-layer pre-assembly does not shift during winding and that the interlayer adhesion is uniform. The core innovation lies in replacing the existing method of "adhesive bonding to fix the pre-assembly and mandrel," achieving adhesive-free fixation through mechanical clamping. This avoids the risk of glue residue contaminating blood and clogging adsorption sites on the adsorption membrane, while simplifying the assembly process and reducing process complexity. Furthermore, the mandrel, as the winding center, ensures the coaxiality of the cylindrical winding, making the blood flow channel thickness consistent in each repeating flow unit, further optimizing the uniformity of radial blood distribution, and forming functional synergy with multi-channel input / output and microcirculation guidance via the flow guide network. This solution is the first to propose the technical concept of "dual-core rod clamping without glue fixation", breaking through the limitations of traditional fixation methods. This design is not a simple addition of core rods, but rather addresses the dual pain points of "assembly safety + structural stability". It is deeply adapted to the core membrane-network coupling architecture, which not only retains the original advantages of high-efficiency adsorption, but also solves the safety hazards in clinical use. It is a non-obvious optimization of the core solution, with outstanding substantive features and significant progress.

[0016] A further preferred technical solution includes a shell, end caps, sealing rings, a blood inlet end, and a blood outlet end; the shell is a hollow cylindrical structure, and the cylindrical winding body is coaxially housed within the shell; end caps are respectively fitted to both ends of the shell, and a sealing ring is provided between each end cap and the end of the shell to achieve a seal; a blood inlet end is integrally formed or fixedly connected to one end cap, and the blood inlet end communicates with the blood input channel of the cylindrical winding body; a blood outlet end is integrally formed or fixedly connected to the other end cap, and the blood outlet end communicates with the blood output channel of the cylindrical winding body; the inner wall of the shell is clearance-fitted with the outer circumferential surface of the cylindrical winding body to limit the radial deformation of the cylindrical winding body.

[0017] The beneficial effects of this invention are as follows: 1. Support and flow guiding function: The flow guiding mesh provides stable support for the adsorption membrane, preventing deformation after the membrane is rolled up; at the same time, the mesh structure guides blood to be evenly distributed on the membrane surface, eliminating the problem of uneven local blood flow; 2. Construction of microcirculation environment: The mesh of the guide net is adapted to the amoeboid movement requirements of blood cells, enabling blood cells to crawl and move on the membrane surface, fully contact the adsorption sites of the membrane, and significantly improve the removal efficiency of activated leukocytes; 3. Simplified and safe assembly method: The three-layer pre-assembled body is sandwiched between mandrel I and mandrel II, eliminating the need for glue bonding, which simplifies the assembly process and avoids the risk of contamination introduced by glue. 4. High structural stability: The combination of interlayer bonding of the three-layer pre-assembled body and mandrel clamping results in a compact cylindrical winding structure after winding, with good blood flow channel closure and is not prone to delamination after long-term use. Attached Figure Description

[0018] Figure 1 This is a three-dimensional structural diagram of the three-layer pre-assembled body described in this invention; Figure 2 This is a schematic diagram of the axial end face structure of the cylindrical winding body described in this invention; Figure 3 is a schematic diagram of the radial cross-sectional structure of the repeating flow unit of the present invention; Figure 4 is a schematic diagram of the blood circulation path of the present invention; Figure 5 is a schematic diagram of the structure of the mandrel described in this invention; Figure 6 is a schematic diagram of the overall assembly structure of the selectively activated leukocyte adsorbent of the present invention; Figure 7 This is a schematic diagram of the dynamic blood flow process; Figure 8 Front view of the selectively activated leukocyte adsorption membrane after use; Figure 9 Reverse view of the selectively activated leukocyte adsorption membrane after use; Figure 10 This is a microscopic view of the activated leukocyte adsorption membrane and the flow-guiding mesh layer under a 1000x scanning electron microscope.

[0019] Reference numerals: 1. Upper guide net; 2. Lower guide net; 3. Selectively activated leukocyte adsorption membrane; 4. Three-layer pre-assembled body; 5. Cylindrical winding body; 6. Repeated flow unit; 7. First guide net layer; 8. First blood flow channel; 9. Selectively activated leukocyte adsorption membrane layer; 10. Second blood flow channel; 11. Second guide net layer; 12. Blood inlet end face; 13. Blood outlet end face; 14. Blood input channel; 15. Blood output channel; 16. Core rod; 17. Core rod I; 18. Core rod II; 19. Shell; 20. End cap; 21. Sealing ring; 22. Blood inlet end; 23. Blood outlet end; 24. Activated leukocyte; 25. Red blood cell. Detailed Implementation

[0020] The present invention will be further described in detail below with reference to the embodiments and accompanying drawings, but the embodiments of the present invention are not limited thereto.

[0021] A flow guide net coupled to a selectively activated leukocyte adsorption membrane 3 is provided. The flow guide net is attached to the surface of the selectively activated leukocyte adsorption membrane 3 and can be wound synchronously with the selectively activated leukocyte adsorption membrane 3. The thickness of the flow guide net is adapted to the movement requirements of blood cell amoebae. The flow guide net has multiple mesh holes, and the pore size of each mesh hole is adapted to the movement requirements of blood cell amoebae, allowing blood cells to complete crawling displacement through the mesh holes, thereby forming a microcirculation environment on the surface of the selectively activated leukocyte adsorption membrane 3 and promoting the contact adsorption of activated leukocytes with the selectively activated leukocyte adsorption membrane 3.

[0022] This guide net, through its bonding and synchronous winding with the selectively activated leukocyte adsorption membrane 3, provides support for the adsorption membrane layer and, with a thickness and mesh size adapted to the movement of blood cell amoebae, guides blood cells to actively crawl and form a microcirculation. This addresses the shortcomings of existing adsorbers, such as lack of support leading to deformation, uneven blood flow, and low utilization of adsorption sites. Existing technologies do not involve the design of a "guide net adapted to the movement of blood cell amoebae." This solution integrates support, guidance, and microcirculation construction functions, breaking through the traditional passive adsorption logic and significantly improving the removal efficiency of activated leukocytes, demonstrating outstanding substantive features and significant progress.

[0023] A further preferred technical solution is that the thickness of the guide net is 0.05mm-0.33mm, and the mesh size is 0.07mm-0.42mm.

[0024] The thickness and mesh pore size range are precisely matched to the spatial and traversal requirements of amoeba movement in blood cells, ensuring that cells actively crawl to form microcirculation while also taking into account the support strength of the flow guide mesh and the smoothness of blood flow. This further improves adsorption efficiency and structural stability, representing a targeted optimization of core technical features and enhancing the practicality of the solution.

[0025] A further preferred technical solution is that the width of the ribs between two adjacent mesh openings is 0.05mm-2mm, and the center-to-center distance between the mesh openings is 0.075mm-0.62mm.

[0026] The design of the rib width and the center-to-center spacing of the mesh ensures both the structural strength of the flow guide and the uniform distribution of the mesh, providing a dense and orderly passage path for the movement of blood cells and amoebae. This avoids blood flow disturbance caused by excessively wide ribs obscuring the surface of the adsorption membrane or excessively large spacing, further optimizing the synergistic effect of the microcirculation environment and adsorption efficiency.

[0027] like Figure 1-2As shown, a selectively activated leukocyte adsorbent includes a flow guide net and a selectively activated leukocyte adsorption membrane 3; the flow guide net includes an upper flow guide net 1 and a lower flow guide net 2, which are respectively tightly attached to the upper and lower surfaces of the selectively activated leukocyte adsorption membrane 3 to form a three-layer pre-assembled body 4 in a rectangular planar shape; the three-layer pre-assembled body 4 is wound to form a cylindrical wound body 5; like Figure 2-4 As shown, the cylindrical winding body 5 includes multiple repeating flow units 6, which are connected sequentially along the radial direction of the cylindrical winding body 5. Each repeating flow unit 6 includes, from the inside to the outside, a first guide mesh layer 7, a first blood flow channel 8, a selectively activated leukocyte adsorption membrane layer 9, a second blood flow channel 10, and a second guide mesh layer 11. The two axial end faces of the cylindrical winding body 5 are a blood inlet end face 12 and a blood outlet end face 13, respectively. A blood input channel 14 is provided at the blood inlet end face 12, and a blood output channel 15 is provided at the blood outlet end face 13. like Figure 4 As shown, Figure 4 The diagram illustrates the blood flow path of this invention. The blood flow path is as follows: Blood enters the cylindrical coil 5 from the blood inlet end face 12 through the blood input channel 14, and flows radially into the first blood flow channel 8 and the second blood flow channel 10 of each repeating flow unit 6. In the blood flow channel, the blood comes into full contact with the surface of the selectively activated leukocyte adsorption membrane layer 9, and the activated leukocytes in the blood are selectively adsorbed by the selectively activated leukocyte adsorption membrane layer 9. The blood cells that are not adsorbed complete the crawling displacement and pass through the first guide mesh layer 7 or the second guide mesh layer 11 by means of the mesh pores adapted to the amoeboid movement of blood cells in the guide mesh layer, thereby forming a microcirculation environment on the surface of the selectively activated leukocyte adsorption membrane layer 9, promoting the contact adsorption of activated leukocytes with the selectively activated leukocyte adsorption membrane layer 9.

[0028] This adsorber forms a three-layer pre-assembled structure by sandwiching an adsorption membrane between upper and lower guide nets. After winding, it constitutes a cylindrical coil containing repeating flow units, achieving orderly blood flow in conjunction with axial blood inlet / outlet channels. The core innovation lies in coupling the guide net with the coiled structure. The guide net provides support for the membrane layer and guides the blood to distribute evenly. Furthermore, its mesh, adapted to amoeba movement, allows blood cells to actively crawl and form microcirculation, completely solving the pain points of existing adsorbers such as lack of support leading to deformation, uneven blood flow, and low utilization of adsorption sites. This solution integrates support, guidance, and high-efficiency adsorption functions, breaking through the traditional passive adsorption logic and significantly improving the removal efficiency of activated leukocytes, demonstrating outstanding substantive features and significant progress.

[0029] A further preferred technical solution is that the blood input channel 14 comprises multiple blood input pipes, which extend along the axial direction of the cylindrical winding body 5 and are correspondingly disposed within the first blood flow channel 8 and the second blood flow channel 10 of each repeating flow unit 6; the blood output channel 15 comprises multiple blood output pipes, which extend along the axial direction of the cylindrical winding body 5 and are correspondingly disposed within the first blood flow channel 8 and the second blood flow channel 10 of each repeating flow unit 6.

[0030] This preferred design employs a precise matching design of "multiple channels corresponding to multiple blood flow pathways," refining the blood input / output channels into multiple channels extending axially along the cylindrical coil. Each repeating flow unit has its first and second blood flow channels configured with dedicated input / output channels. Its core value lies in two aspects: firstly, overcoming the problem of uneven radial blood distribution caused by traditional single inlet / outlet systems, allowing blood to be delivered directly and evenly to each blood flow channel; secondly, the dedicated output channels can promptly remove adsorbed blood, reducing retention and backflow within the channels. This synergizes with the microcirculation guidance function of the flow guide net, ensuring "macroscopic uniform distribution" through the channels and achieving "microscopic active crawling" through the flow guide net. This dual effect further enhances the contact efficiency between blood and the adsorption membrane.

[0031] like Figure 1 , 2 As shown in Figure 5, the mandrel 16 includes mandrel I17 and mandrel II18 arranged opposite to each other, which sandwich the three-layer pre-assembled body 4 in the middle, and the three-layer pre-assembled body 4 is wound along the axial direction of the mandrel 16.

[0032] This preferred design, through the "three-layer pre-assembly sandwiched between mandrels I and II positioned opposite each other," provides a stable benchmark for winding and forming. Simultaneously, winding along the mandrel axis ensures that the three-layer pre-assembly does not shift during winding and that the interlayer adhesion is uniform. The core innovation lies in replacing the existing method of "adhesive bonding to fix the pre-assembly and mandrel," achieving adhesive-free fixation through mechanical clamping. This avoids the risk of glue residue contaminating blood and clogging adsorption sites on the adsorption membrane, while simplifying the assembly process and reducing process complexity. Furthermore, the mandrel, as the winding center, ensures the coaxiality of the cylindrical winding, making the blood flow channel thickness consistent in each repeating flow unit, further optimizing the uniformity of radial blood distribution, and forming functional synergy with multi-channel input / output and microcirculation guidance via the flow guide network. This solution is the first to propose the technical concept of "dual-core rod clamping without glue fixation", breaking through the limitations of traditional fixation methods. This design is not a simple addition of core rods, but rather addresses the dual pain points of "assembly safety + structural stability". It is deeply adapted to the core membrane-network coupling architecture, which not only retains the original advantages of high-efficiency adsorption, but also solves the safety hazards in clinical use. It is a non-obvious optimization of the core solution, with outstanding substantive features and significant progress.

[0033] like Figure 6 As shown, Figure 6 This is a schematic diagram of the overall assembly structure of the selectively activated leukocyte adsorbent of the present invention. The selectively activated leukocyte adsorbent also includes a shell 19, end caps 20, sealing rings 21, a blood inlet end 22, and a blood outlet end 23. The shell 19 is a hollow cylindrical structure, and the cylindrical coil 5 is coaxially housed within the shell 19. End caps 20 are respectively fitted to both ends of the shell 19, and a sealing ring 21 is provided between each end cap 20 and the end of the shell 19 to achieve sealing of the shell 19. One end cap 20 is integrally formed or fixedly connected to a blood inlet end 22, which communicates with the blood input channel 14 of the cylindrical coil 5. The other end cap 20 is integrally formed or fixedly connected to a blood outlet end 23, which communicates with the blood output channel 15 of the cylindrical coil 5. The inner wall of the shell 19 is clearance-fitted with the outer circumferential surface of the cylindrical coil 5 to limit the radial deformation of the cylindrical coil 5.

[0034] like Figure 7 As shown in the figure, this diagram illustrates the dynamic blood flow process, clearly showing the flow logic of blood within the adsorber. The arrows indicate the flow trajectory of blood in the second guide mesh layer 11. Blood does not pass through in a straight line quickly, but forms an orderly microcirculation under the guidance of the second guide mesh layer 11, creating conditions for the movement of blood cell amoebas and ensuring that the blood is in full contact with the surface of the selectively activated leukocyte adsorption membrane layer 9.

[0035] like Figure 8 As shown, Figure 8 This image shows the physical state of the selectively activated leukocyte adsorption membrane after the adsorber has been used, highlighting the technical effects of "high adsorption efficiency and full membrane utilization." 1. Adsorption uniformity: Dense and uniformly distributed adsorption sites (areas where activated leukocytes attach) are visible on the membrane surface, with no obvious "blank unused areas," proving that the uniform blood flow distribution design is effective and solves the problem of "partial membrane without blood flow and low utilization rate" in existing structures; 2. Adsorption capacity verification: The number of activated leukocytes adsorbed on the front side is sufficient, which directly reflects that the adsorption performance of the adsorption membrane is not affected by the structural design. Moreover, due to the full contact with blood flow, the adsorption capacity is better than that of the traditional structure. 3. Structural compatibility: The membrane surface is free of wrinkles and deformation, which confirms the supporting role of the flow guiding mesh and ensures that the adsorption membrane remains flat during use, further guaranteeing the adsorption effect.

[0036] like Figure 9 As shown, Figure 9 This image shows the reverse side of the selectively activated leukocyte adsorption membrane after use, verifying the adsorption effect on the reverse side and demonstrating the advantage of "double-sided utilization." This image, along with Figure 8, forms a front-to-back comparison, highlighting the design feature of "maximizing membrane area utilization." 1. Double-sided adsorption capacity: The reverse side of the adsorption membrane also shows uniformly distributed adsorption traces of activated leukocytes, proving that blood can fully penetrate to both sides of the membrane under the action of microcirculation, rather than only contacting one side, thus solving the problem of "insufficient membrane area utilization" in traditional structures. 2. Selective adsorption verification: The figure does not show a large number of unrelated blood cells such as red blood cells adhering to the membrane. Only activated white blood cells are selectively adsorbed, which confirms the "selective" function of the adsorption membrane and shows that the combination of the flow guide net and the membrane does not affect the core adsorption characteristics of the membrane. 3. Proof of no adhesive contamination: There is no adhesive residue or impurities on the membrane surface, which echoes the design of "no adhesive required for fixing" and avoids the risk of allergies and infections caused by traditional structural adhesives, reflecting the safety of use.

[0037] like Figure 10 As shown in the figure, this is a microscopic view under a 1000x scanning electron microscope. The figure clearly shows that the selectively activated leukocyte adsorption membrane 9 adsorbs a large number of activated leukocytes 24, erythrocytes 25, and other unadsorbed blood cells. With the help of the mesh pores of the guide mesh layer adapted to the movement of blood cell amoebae, they complete the crawling displacement and pass through the guide mesh layer, thereby forming a microcirculatory environment on the surface of the selectively activated leukocyte adsorption membrane 9, which promotes the contact adsorption of activated leukocytes with the selectively activated leukocyte adsorption membrane 9.

[0038] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention in any way. Based on the technical essence of the present invention, any simple modifications, equivalent substitutions, and improvements made to the above embodiments within the spirit and principles of the present invention shall still fall within the protection scope of the present invention.

Claims

1. A guide net coupled with a selective leukocyte adsorption membrane, characterized in that, The flow guide net is arranged on the surface of the selective activated leukocyte adsorption membrane (3) and can be wound synchronously with the selective activated leukocyte adsorption membrane (3); the thickness of the flow guide net is adapted to the ameba movement requirement of blood cells; the flow guide net is provided with a plurality of mesh holes, the aperture of each mesh hole is adapted to the ameba movement requirement of blood cells, and blood cells are allowed to complete crawling displacement through the mesh holes, so that a microcirculation environment is formed on the surface of the selective activated leukocyte adsorption membrane, and the contact adsorption of activated leukocytes and the selective activated leukocyte adsorption membrane is promoted.

2. The guide net coupled with selective activated leukocyte adsorption film according to claim 1, characterized in that, The thickness of the flow guide net is 0.05mm-0.33mm, and the aperture of the mesh hole is 0.07mm-0.42mm.

3. The mesh according to claim 1, wherein the mesh is coupled to a selective leukocyte-adsorbing membrane. The width of the rib between two adjacent mesh holes is 0.05mm-2mm, and the center distance between the mesh holes is 0.075mm-0.62mm.

4. A selective leukocyte adsorber comprising, The flow guide net, the selective activated leukocyte adsorption membrane (3), the upper flow guide net (1) and the lower flow guide net (2) are arranged on the upper and lower surfaces of the selective activated leukocyte adsorption membrane (3) respectively, and a three-layer pre-assembled body (4) in the shape of a rectangular plane is formed; the three-layer pre-assembled body (4) is wound to form a cylindrical winding body (5); The cylindrical winding body (5) comprises a plurality of repeated flow-through units (6), the repeated flow-through units (6) are sequentially connected along the radial direction of the cylindrical winding body (5), each repeated flow-through unit (6) comprises, from the inside to the outside, a first flow guide net layer (7), a first blood flow channel (8), a selective activated leukocyte adsorption membrane layer (9), a second blood flow channel (10), and a second flow guide net layer (11); two axial end faces of the cylindrical winding body (5) are a blood inlet end face (12) and a blood outlet end face (13), respectively; a blood input channel (14) is arranged at the blood inlet end face (12), and a blood output channel (15) is arranged at the blood outlet end face (13); The blood flow path is as follows: blood enters the cylindrical winding body (5) from the blood inlet end face (12) through the blood input channel (14) and is dispersed along the radial direction into the first blood flow channel (8) and the second blood flow channel (10) of each repeated flow-through unit (6); in the blood flow channel, blood is in full contact with the surface of the selective activated leukocyte adsorption membrane layer (9), and activated leukocytes in the blood are selectively adsorbed by the selective activated leukocyte adsorption membrane layer (9); blood cells that are not adsorbed complete crawling displacement by means of the mesh holes of the flow guide net layer adapted to the ameba movement of blood cells and pass through the first flow guide net layer (7) or the second flow guide net layer (11), so that a microcirculation environment is formed on the surface of the selective activated leukocyte adsorption membrane layer (9), and the contact adsorption of activated leukocytes and the selective activated leukocyte adsorption membrane layer (9) is promoted.

5. The selective leukocyte adsorber of claim 4, wherein, The blood input channel (14) is a plurality of blood input pipes extending along the axial direction of the cylindrical winding body (5) and arranged in the first blood flow channel (8) and the second blood flow channel (10) of each repeating flow unit (6) correspondingly.

6. The selective leukocyte adsorber of claim 4, wherein, The core rod (16) includes oppositely arranged core rod I (17) and core rod II (18), which sandwich the three-layer pre-assembled body (4) in the middle, and the three-layer pre-assembled body (4) is wound along the axial direction of the core rod (16).

7. The selective leukocyte adsorber of claim 4, wherein, The shell (19) is a hollow cylindrical structure, and the cylindrical winding body (5) is coaxially contained in the shell (19); the two ends of the shell (19) are respectively fitted with end covers (20), and a sealing ring (21) is arranged between each end cover (20) and the end of the shell (19) to realize the sealing of the shell (19); one of the end covers (20) is integrally formed or fixedly connected with a blood flow inlet end (22), and the blood flow inlet end (22) is in communication with the blood input channel (14) of the cylindrical winding body (5); the other end cover (20) is integrally formed or fixedly connected with a blood outlet end (23), and the blood outlet end (23) is in communication with the blood output channel (15) of the cylindrical winding body (5); the inner wall of the shell (19) and the outer peripheral surface of the cylindrical winding body (5) are in clearance fit, which is used to limit the radial deformation of the cylindrical winding body (5).

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