Supramolecular amino acid facial cleanser and preparation method thereof

Abstract

The invention belongs to the technical field of cosmetics, and particularly relates to a supramolecular amino acid facial cleanser and a preparation method thereof. The facial cleanser comprises the following components: 15-35% of a basic amino acid surfactant and an acidic amino acid surfactant in a molar ratio of (1-2): 1; 3-6% of cyclodextrin; 5-15% of a skin conditioner; and the balance of water. The preparation method comprises the following steps: adding cyclodextrin into hot water for dissolving, then adding the skin conditioner, stirring and mixing uniformly, then sequentially adding the alkaline amino acid surfactant and the acidic amino acid surfactant, homogenizing and mixing uniformly, naturally cooling to room temperature, adjusting the pH value to 5.5-6.5, and defoaming in vacuum to obtain the product. According to the invention, the amino acid surfactant with a specific ratio is self-assembled to form a supramolecular group, so that the problems that the conventional amino acid facial cleanser is large in crystal, unstable and easy to thicken in the later period are solved, and the cleansing and oil-controlling effects which are synergistically improved are achieved.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology, specifically relating to a supramolecular amino acid facial cleanser and its preparation method. Background Technology

[0002] Amino acid facial cleansers are a type of facial cleansing product with amino acid surfactants as the main cleansing active ingredients. Amino acid surfactants are bio-based, naturally derived amino acid derivatives, which have the advantages of being safe, gentle, low-irritant, and having good compatibility with the skin, making amino acid facial cleansers increasingly popular in the market.

[0003] However, amino acid facial cleansers currently have the following problems: First, the crystals are unstable and tend to be coarse, with little pearlescent sheen, requiring a rapid condensation crystallization process to improve the uniformity and stability of the thickened crystals; second, their cleansing and oil-controlling abilities are somewhat insufficient, requiring them to be used in combination with soap-based cleansing components.

[0004] Supramolecular molecules are complex, organized aggregates composed of two or more molecules bonded together by intermolecular interactions. Amino acid surfactants, due to their high hydrogen-bonding group content, possess the ability to form supramolecular compositions. For example, invention patent WO2019233377A1 discloses a novel amino acid self-assembled supramolecular polymer, its preparation method, and its applications. Using N-lauroyl-L-alanyl-L-alanine as the basic unit, it self-assembles into a supramolecular polymer through hydrogen bonding, demonstrating more effective antibacterial and pesticide-removing effects in the daily chemical, agricultural, and pharmaceutical industries. However, the basic unit N-lauroyl-L-alanyl-L-alanine used in this supramolecular polymer requires a special preparation method, resulting in limited raw material sources and high costs. Furthermore, the supramolecular polymer has not been shown to improve crystal uniformity and stability, or enhance cleaning and oil-controlling capabilities. Summary of the Invention

[0005] In view of the shortcomings and deficiencies of the existing technology, the primary objective of this invention is to provide a supramolecular amino acid facial cleanser.

[0006] Another object of the present invention is to provide a method for preparing the above-mentioned supramolecular amino acid facial cleanser.

[0007] The objective of this invention is achieved through the following technical solution:

[0008] A supramolecular amino acid facial cleanser comprises the following components in weight percentage:

[0009] The molar ratio of alkaline amino acid surfactants and acidic amino acid surfactants is 15-35% (1-2):1.

[0010] Cyclodextrin 3-6%;

[0011] Skin conditioning agent 5-15%;

[0012] The remainder is water.

[0013] The alkaline amino acid surfactant described in this invention refers to an amino acid surfactant containing residual alkaline amine groups and having a weakly alkaline pH value, preferably one or both of sodium cocoyl glycinate and potassium cocoyl glycinate. The aforementioned preferred alkaline amino acid surfactants are mature commercial products, widely available, and inexpensive.

[0014] The acidic amino acid surfactant described in this invention refers to an amino acid surfactant containing a residual acidic carboxyl group and having a weakly acidic pH value, preferably one or both of lauroyl glutamic acid and cocoyl glutamic acid. The aforementioned preferred acidic amino acid surfactants are mature commercial products, widely available, and relatively inexpensive.

[0015] The key to this invention lies in the self-assembly of alkaline amino acid surfactants and acidic amino acid surfactants with a molar ratio of (1~2):1 to form supramolecular clusters. Under the condition of not needing to use a rapid condensation crystallization process, a uniform and stable thickened crystal is formed by self-crystallization, which solves the problem that conventional amino acid facial cleansers have large and unstable crystals and are prone to coarsening in the later stage, and has a synergistically improved cleaning and oil control effect.

[0016] The molar ratio of the basic amino acid surfactant to the acidic amino acid surfactant is preferably 1:1. Under the above-mentioned preferred molar ratio conditions, the effect of forming supramolecular stable crystals is even better.

[0017] The cyclodextrin used in this invention is preferably β-cyclodextrin. Through the hydrogen-bonded supramolecular synergistic effect of the high hydroxyl content of β-cyclodextrin and its thickening and film-forming properties, the uniformity and stability of the crystals are further improved, resulting in a finer pearlescent finish in the amino acid facial cleanser.

[0018] The skin conditioning agent of this invention comprises glycerin, 1,2-hexanediol, and plant-based cleansing and oil-controlling components. These plant-based cleansing and oil-controlling components include Sophora angustifolia root extract, Chrysanthemum sinense flower extract, Sapindus mukorossi fruit extract, and Olea europaea leaf extract, with each extract comprising no less than 20% of the total mass of the plant-based cleansing and oil-controlling components. All of the above-mentioned plant-based cleansing and oil-controlling components are commercially available raw materials in the art.

[0019] This invention enhances the cleaning and oil-controlling efficacy of amino acid surfactants by employing specific plant-based cleaning and oil-controlling components.

[0020] The mass percentage of each component in the above skin conditioning agent in the supramolecular amino acid facial cleanser is as follows:

[0021] Glycerin 5-12%, 1,2-hexanediol 1-3%, plant-based cleansing and oil-controlling components 0.1-1%.

[0022] The preparation method of the above-mentioned supramolecular amino acid facial cleanser includes the following preparation steps:

[0023] Cyclodextrin was dissolved in hot water at 80-90℃, then cooled to 50-60℃. Skin conditioning agent was added and stirred until homogeneous. Alkaline amino acid surfactant and acidic amino acid surfactant were added in sequence and homogenized until homogeneous. The mixture was allowed to cool naturally to room temperature. Citric acid was added to adjust the pH of the system to 5.5-6.5. Vacuum defoaming was performed to obtain supramolecular amino acid facial cleanser.

[0024] In the above preparation method, the method of first dissolving cyclodextrin and then adding amino acid surfactant can better improve the uniformity and stability of crystals.

[0025] Compared with the prior art, the beneficial effects of the present invention are:

[0026] (1) By using a specific ratio of alkaline amino acid surfactants and acidic amino acid surfactants to self-assemble into supramolecular clusters, the problem of large and unstable crystals in conventional amino acid facial cleansers, which are prone to coarsening in the later stages, is solved, and the cleaning and oil control effects are synergistically improved.

[0027] (2) Through the hydrogen bond supramolecular synergistic effect and thickening film-forming properties of cyclodextrin, the uniformity and stability of the crystals are further improved, and the resulting amino acid facial cleanser pearls are made more delicate.

[0028] (3) Through a specific preparation process, the uniformity and stability of the crystals can be guaranteed without the need for a rapid condensation crystallization process.

[0029] (4) Carefully selected plant-based cleaning and oil-controlling components work synergistically to enhance the cleaning and oil-controlling effects of amino acid surfactants, eliminating the need for soap-based cleaning components and maintaining the product's advantages of being gentle, low-irritant, and highly safe. Attached Figure Description

[0030] Figure 1 The images show a comparison of the appearance of the amino acid facial cleansers obtained in Example 1 and Comparative Example 1.

[0031] Figure 2 The images show a comparison of the microscopic morphology of the amino acid facial cleansers obtained in Example 1 and Comparative Example 1.

[0032] Figure 3 The image shows a comparison of the crystal microstructures of the amino acid facial cleansers obtained in Example 1 and Comparative Example 1.

[0033] Figure 4 This is a diagram showing the appearance of the amino acid facial cleanser obtained in Example 6.

[0034] Figure 5 This is a diagram showing the appearance of the amino acid facial cleanser obtained in Example 7.

[0035] Figure 6 The image shows the appearance of the amino acid facial cleanser obtained in Comparative Example 2.

[0036] Figure 7 The image shows the appearance of the amino acid facial cleanser obtained in Comparative Example 3. Detailed Implementation

[0037] The present invention will be further described in detail below with reference to the embodiments and accompanying drawings, but the embodiments of the present invention are not limited thereto.

[0038] Example 1

[0039] A supramolecular amino acid facial cleanser is prepared from the following components in weight percentages:

[0040] Sodium cocoyl glycinate and 22% lauroyl glutamic acid in a molar ratio of 1:1;

[0041] β-Cyclodextrin 4%;

[0042] 9% glycerol;

[0043] 1,2-Hexanediol 1.5%;

[0044] Plant-based cleansing and oil-controlling ingredients: 0.6%;

[0045] The plant-based cleansing and oil-controlling component consists of Sophora angustifolia root extract, Sapindus mukorossi fruit extract, Chrysanthem sinese flower extract, and Olea europaea leaf extract in a mass ratio of 3:3:2:2.

[0046] Deionized water up to 100%.

[0047] The preparation method of the supramolecular amino acid facial cleanser is as follows:

[0048] Dissolve the weighed β-cyclodextrin in deionized water at 80-90℃, then cool to 50-60℃. Add glycerin, 1,2-hexanediol, and the pre-prepared plant-based cleansing and oil-controlling components and stir until well mixed. Then add sodium cocoyl glycinate and lauroyl glutamic acid in sequence and homogenize until well mixed. Allow to cool naturally to room temperature, add citric acid to adjust the pH of the system to 6.0, and defoam under vacuum to obtain a supramolecular amino acid facial cleanser.

[0049] Performance test of the obtained supramolecular amino acid facial cleanser:

[0050] 1. Appearance: White, delicate, pearlescent cream (its appearance is shown in the image). Figure 1 As shown; microscopic morphology diagram of the ointment. Figure 2 As shown; crystal microstructure diagram as follows Figure 3 (As shown).

[0051] 2. Stability: Heat resistance was tested by storing the product in a 45℃ constant temperature incubator for 3 months; cold resistance was tested by storing it in a -15℃ refrigerator for 3 months. The results showed that the morphology of the resulting paste did not change significantly.

[0052] 3. Cleaning Effect: Five square test skins with sides of 10cm were taken and cleaned. Each test skin was then placed in a PM2.5-colored smog environment for 10 minutes. After removal, the content of colored pollutants was analyzed by the instrument and recorded as A0. The test skins were then cleaned with the prepared supramolecular amino acid facial cleanser, allowed to air dry, and the residual amount of colored pollutants was tested again and recorded as A1. The pollutant removal rate was calculated as (A0 - A1 / A0) * 100%, and the average value was taken. The results showed that the pollutant removal rate was 95.4%.

[0053] 4. Oil Control Effect: Participants aged 20-45 were selected and divided into groups of five. The experiment was conducted in a room with room temperature and humidity of 50-55%. Two 2cm x 2cm test areas were drawn on the participants' foreheads. One area was cleansed with the supramolecular amino acid facial cleanser of this embodiment (experimental group), while the other area was cleansed only with water (blank group). A skin oil analyzer was used to measure the skin oil content in both areas at the end of cleansing and 2 hours later. The relative change rate of oil was calculated as: (Increase in oil content in the experimental group - Increase in oil content in the blank group) / Increase in oil content in the blank group * 100%. The average value was taken. The results showed a relative change rate of -41.5%.

[0054] Example 2

[0055] A supramolecular amino acid facial cleanser is prepared from the following components in weight percentages:

[0056] Sodium cocoyl glycinate and 18% lauroyl glutamic acid in a 1:1 molar ratio;

[0057] β-Cyclodextrin 5%;

[0058] Glycerin 6%;

[0059] 1,2-Hexanediol 2%;

[0060] Plant-based cleansing and oil-controlling ingredients 1%;

[0061] The plant-based cleansing and oil-controlling component consists of Sophora flavescens root extract, Sapindus mukorossi fruit extract, Chrysanthemum sinense flower extract, and Olive oil leaf extract in a mass ratio of 2.5:2.5:2.5:2.5.

[0062] Deionized water up to 100%.

[0063] The resulting supramolecular amino acid facial cleanser was a white, delicate, pearlescent paste. The appearance of the paste did not change significantly after heat resistance and cold resistance tests.

[0064] Example 3

[0065] A supramolecular amino acid facial cleanser is prepared from the following components in weight percentages:

[0066] Potassium cocoyl glycinate and 15% cocoyl glutamic acid in a molar ratio of 1:1;

[0067] β-Cyclodextrin 3%;

[0068] 5% glycerin;

[0069] 1,2-Hexanediol 3%;

[0070] Plant-based cleansing and oil-controlling ingredients 1%;

[0071] The plant-based cleansing and oil-controlling component consists of Sophora flavescens root extract, Sapindus mukorossi fruit extract, Chrysanthemum sinense flower extract, and Olive oil leaf extract in a mass ratio of 2.5:2.5:2.5:2.5.

[0072] Deionized water up to 100%.

[0073] The resulting supramolecular amino acid facial cleanser was a white, delicate, pearlescent paste. The appearance of the paste did not change significantly after heat resistance and cold resistance tests.

[0074] Example 4

[0075] A supramolecular amino acid facial cleanser is prepared from the following components in weight percentages:

[0076] Sodium cocoyl glycinate and 30% cocoyl glutamic acid in a molar ratio of 1:1;

[0077] β-Cyclodextrin 5%;

[0078] 10% glycerin;

[0079] 1,2-Hexanediol 1.5%;

[0080] Plant-based cleansing and oil-controlling ingredients: 0.4%;

[0081] The plant-based cleansing and oil-controlling component consists of Sophora angustifolia root extract, Sapindus mukorossi fruit extract, Chrysanthem sinese flower extract, and Olea europaea leaf extract in a mass ratio of 2:2:3:3.

[0082] Deionized water up to 100%.

[0083] The resulting supramolecular amino acid facial cleanser was a white, delicate, pearlescent paste. The appearance of the paste did not change significantly after heat resistance and cold resistance tests.

[0084] Example 5

[0085] A supramolecular amino acid facial cleanser is prepared from the following components in weight percentages:

[0086] Sodium cocoyl glycinate and 35% cocoyl glutamic acid in a molar ratio of 1:1;

[0087] β-Cyclodextrin 6%;

[0088] Glycerin 12%;

[0089] 1,2-Hexanediol 1%;

[0090] Plant-based cleansing and oil-controlling ingredients: 0.1%;

[0091] The plant-based cleansing and oil-controlling component consists of Sophora angustifolia root extract, Sapindus mukorossi fruit extract, Chrysanthem sinese flower extract, and Olea europaea leaf extract in a mass ratio of 3:2:3:2.

[0092] Deionized water up to 100%.

[0093] The resulting supramolecular amino acid facial cleanser was a white, delicate, pearlescent paste. The appearance of the paste did not change significantly after heat resistance and cold resistance tests.

[0094] Example 6

[0095] A supramolecular amino acid facial cleanser, compared with Example 1, has its molar ratio of sodium cocoyl glycinate and lauroyl glutamic acid adjusted to 2:1, with the rest remaining the same.

[0096] The resulting supramolecular amino acid facial cleanser has a white, delicate, pearlescent paste-like appearance (see image below). Figure 4 (As shown in the image). Heat and cold stability tests revealed a coarse texture and reduced pearlescent sheen. Cleaning effectiveness tests showed a contaminant removal rate of 90.4%. Oil control effectiveness tests showed a relative change rate of -31.0% in oil content.

[0097] The comparison with Example 1 shows that the molar ratio of alkaline amino acid surfactant to acidic amino acid surfactant is 1:1, which results in a better formation of supramolecular stable crystals and a better cleaning and oil control effect.

[0098] Example 7

[0099] A supramolecular amino acid facial cleanser has the same component composition as in Example 1, but differs in its preparation method as follows:

[0100] Dissolve the weighed sodium cocoyl glycinate and lauroyl glutamic acid in deionized water at 80-90℃, then add β-cyclodextrin and mix well. Cool to 50-60℃, add glycerol, 1,2-hexanediol and the pre-prepared plant-based cleansing and oil-controlling components, stir and mix evenly, let cool naturally to room temperature, add citric acid to adjust the pH of the system to 6.0, and defoam under vacuum to obtain a supramolecular amino acid facial cleanser.

[0101] The resulting supramolecular amino acid facial cleanser has a white, delicate, pearlescent paste-like appearance (see image below). Figure 5 (As shown in the image). Heat and cold stability tests revealed a coarse texture and reduced pearlescent sheen. Cleaning effectiveness tests showed a contaminant removal rate of 92.1%. Oil control effectiveness tests showed a relative change rate of -32.7% in oil content.

[0102] The comparison results with Example 1 show that the present invention can better improve the uniformity and stability of crystals by dissolving cyclodextrin first and then adding amino acid surfactants, and also improves the cleansing and oil-controlling effect of facial cleanser.

[0103] Comparative Example 1

[0104] A supramolecular amino acid facial cleanser, compared with Example 1, uses an equimolar amount of sodium lauroyl glutamate instead of lauroyl glutamic acid, all other aspects are the same.

[0105] The resulting supramolecular amino acid facial cleanser appeared as a white, rough paste with no obvious pearlescent sheen (its appearance is shown in the figure below). Figure 1 As shown; microscopic morphology diagram of the ointment. Figure 2 As shown; crystal microstructure diagram as follows Figure 3 (As shown in the image); the paste separated after heat and cold stability tests (due to the destruction of some thickening crystals). Cleaning effectiveness test results showed a contaminant removal rate of 82.7%. Oil control effectiveness test results showed a relative change rate of -19.8% in oil content.

[0106] Comparative Example 2

[0107] A supramolecular amino acid facial cleanser, compared with Example 1, has its molar ratio of sodium cocoyl glycinate and lauroyl glutamic acid adjusted to 3:1, with the rest remaining the same.

[0108] The resulting supramolecular amino acid facial cleanser has a white, rough paste-like appearance with poor pearlescent luster (its appearance is shown in the figure). Figure 6 (As shown in the image). The paste separated after heat and cold stability tests. Cleaning effectiveness test results showed a contaminant removal rate of 88.5%. Oil control effectiveness test results showed a relative change rate of -25.6% in oil content.

[0109] Comparative Example 3

[0110] A supramolecular amino acid facial cleanser, compared with Example 1, does not contain cyclodextrin, but has the same other functional components.

[0111] The resulting supramolecular amino acid facial cleanser has a white, rough paste-like appearance with poor pearlescent luster (its appearance is shown in the figure). Figure 7 (As shown in the image). The paste separated after heat and cold stability tests. Cleaning effectiveness test results showed a contaminant removal rate of 95.8%. Oil control effectiveness test results showed a relative change rate of -42.2% in oil content.

[0112] The comparison results between Comparative Examples 1-3 and Example 1 show that the use of a specific ratio of alkaline amino acid surfactants and acidic amino acid surfactants, combined with cyclodextrin, is the key to improving the uniformity and stability of crystals; at the same time, the use of a specific ratio of alkaline amino acid surfactants and acidic amino acid surfactants is the key to synergistically improving the cleaning and oil control effect.

[0113] The above embodiments are preferred embodiments of the present invention, but the embodiments of the present invention are not limited to the above embodiments. Any changes, modifications, substitutions, combinations, or simplifications made without departing from the spirit and principle of the present invention shall be considered equivalent substitutions and shall be included within the protection scope of the present invention.

Claims

1. A supramolecular amino acid facial cleanser, characterized in that... The components include the following components by mass percentage: The molar ratio of alkaline amino acid surfactants and acidic amino acid surfactants is 15-35% (1-2):

1. Cyclodextrin 3-6%; Skin conditioning agent 5-15%; The remainder is water.

2. The supramolecular amino acid facial cleanser according to claim 1, characterized in that: The alkaline amino acid surfactant is one or both of sodium cocoyl glycinate and potassium cocoyl glycinate.

3. The supramolecular amino acid facial cleanser according to claim 1, characterized in that: The acidic amino acid surfactant is one or both of lauroyl glutamic acid and cocoyl glutamic acid.

4. A supramolecular amino acid facial cleanser according to any one of claims 1 to 3, characterized in that: The molar ratio of the alkaline amino acid surfactant to the acidic amino acid surfactant is 1:

1.

5. The supramolecular amino acid facial cleanser according to claim 1, characterized in that: The cyclodextrin mentioned is β-cyclodextrin.

6. The supramolecular amino acid facial cleanser according to claim 1, characterized in that: The skin conditioning agent comprises glycerin, 1,2-hexanediol, and plant-based cleansing and oil-controlling components; the plant-based cleansing and oil-controlling components comprise Sophora flavescens root extract, Chrysanthemum morifolium flower extract, Sapindus mukorossi fruit extract, and Olive leaf extract, and the content of each extract is not less than 20% of the total mass of the plant-based cleansing and oil-controlling components.

7. The supramolecular amino acid facial cleanser according to claim 6, characterized in that: The mass percentage of each component in the skin conditioning agent in the supramolecular amino acid facial cleanser is as follows: Glycerin 5-12%, 1,2-hexanediol 1-3%, plant-based cleansing and oil-controlling components 0.1-1%.

8. A method for preparing a supramolecular amino acid facial cleanser according to any one of claims 1 to 7, characterized in that... The preparation steps include the following: Cyclodextrin was dissolved in hot water at 80-90℃, then cooled to 50-60℃. Skin conditioning agent was added and stirred until homogeneous. Alkaline amino acid surfactant and acidic amino acid surfactant were added in sequence and homogenized until homogeneous. The mixture was allowed to cool naturally to room temperature. Citric acid was added to adjust the pH of the system to 5.5-6.

5. Vacuum defoaming was performed to obtain supramolecular amino acid facial cleanser.

Images