Ultrasonic coupling bag, ultrasonic coupling agent and preparation method of ultrasonic coupling agent

Abstract

The invention discloses an ultrasonic coupling bag, an ultrasonic coupling agent and a preparation method of the ultrasonic coupling agent. The ultrasonic coupling agent comprises a first component and a second component, wherein the first component is prepared from the following raw materials in parts by weight: 90 to 110 parts of phenyl xylene ethane; 0.8 to 1.2 parts of 2, 5-diphenyl oxazole; 7 to 12 parts of polymethyl methacrylate; 90 to 110 parts of dichloromethane; 2 to 3 parts of Span; 90 to 110 parts of deionized water; the second component is prepared from poloxamer F188 and deionized water; wherein the mass ratio of the first component to the poloxamer F188 to the deionized water is (2 to 3) to 1 to (4 to 6).

Description

Technical Field

[0001] This application relates to the field of ultrasonic coupling agent technology, specifically to an ultrasonic coupling bag, an ultrasonic coupling agent, and a method for preparing the same. Background Technology

[0002] Ultrasound diagnostic technology, due to its non-invasive, real-time, and low-cost advantages, has become an indispensable imaging examination method in clinical medicine. During ultrasound examinations, ultrasound coupling gel plays a crucial role. Its basic principle is that if an air gap exists between the ultrasound probe and the skin, the extremely low acoustic impedance of air, compared to the significant difference in acoustic impedance between air and human skin or soft tissue, will cause strong reflection of ultrasound waves at the interface, preventing them from effectively penetrating the skin and entering the tissue. The role of the coupling gel is to fill the tiny gap between the probe and the skin, eliminating air and achieving a matched transition of acoustic impedance, thereby ensuring efficient penetration of ultrasound waves and obtaining clear, high-quality diagnostic images.

[0003] Currently, ultrasound coupling media widely used in clinical practice are mainly divided into two categories. One category is traditional coupling agents, which are applied directly to the patient's skin surface. These agents can be contaminated with microorganisms during use, posing a risk of cross-infection for patients with broken or ulcerated skin or undergoing postoperative examinations. While these coupling agents are relatively inexpensive, they are for single use only, requiring a large amount of tissues to wipe them off after the examination, resulting in resource waste, environmental pollution, and increased workload for medical staff. Although sterile or disinfectant coupling agents have emerged on the market, their single-use nature remains unchanged. Furthermore, when examining wounds or special areas (such as during surgery), extremely high requirements are placed on the sterility and safety of the product. Existing sterile gel products offer limited choices and are expensive.

[0004] Another type is the solid or semi-solid coupling pad, with hydrogel coupling pads being the most common. These products are typically for single use, applied directly to the patient's skin for ultrasound examination. Compared to traditional gels, some hydrogel coupling pads offer the advantages of leaving no residue and requiring no wiping. However, the thickness of existing coupling pads is usually fixed, making real-time adjustment impossible based on changes in examination depth and focusing area during the examination. Although studies have indicated that the thickness of the coupling layer significantly affects sound wave transmission efficiency—for example, in some acoustic fluid control devices, precise thickness optimization is required to achieve optimal coupling—existing coupling pads are mostly designed for direct skin contact. If used on broken skin, they also face the risk of cross-contamination and are difficult to thoroughly clean and disinfect for reuse. Summary of the Invention

[0005] To address the aforementioned deficiencies in this field, this application aims to provide an ultrasonic coupling bag, an ultrasonic coupling agent, and a method for preparing the same.

[0006] According to one aspect of this application, an ultrasonic coupling agent is provided, the ultrasonic coupling agent comprising a first component and a second component;

[0007] The first component is prepared from the following raw materials in parts by weight: 90-110 for phenylxyl ethane; 2,5-Diphenyloxazole 0.8-1.2; Polymethyl methacrylate 7-12; Dichloromethane 90-110; 202-3; Deionized water 90-110; The second component includes: Poloxamer F188 and deionized water; The mass ratio of the first component, Poloxamer F188, to deionized water is (2-3):1:(4-6).

[0008] According to some embodiments of this application, the first component is prepared from raw materials comprising the following parts by weight: 100g of phenylxylmethylethane; 2,5-Diphenyloxazole 1; Polymethyl methacrylate 9; 100g of dichloromethane; Span 202.5; 100% deionized water; Optionally, the mass ratio of the first component: poloxamer F188: deionized water is 2.5:1:5.

[0009] According to another aspect of this application, a method for preparing the above-mentioned ultrasonic coupling agent is provided, comprising: A 2,5-diphenyloxazole-phenylxylethane solution was prepared by adding 2,5-diphenyloxazole to phenylxylethane. Polymethyl methacrylate (PMMA) is added to dichloromethane to prepare a PMMA solution; A solution of 2,5-diphenyloxazole-phenylxylene ethane was mixed with a solution of polymethyl methacrylate to form an oil phase. The oil phase was mixed with an aqueous solution of Span 20 to obtain a suspension, which was then dried to obtain a powder. The ultrasonic coupling agent was prepared by mixing and dissolving the powder with poloxamer F188 in deionized water.

[0010] According to some embodiments of this application, the volume ratio of 2,5-diphenyloxazole-phenylxylylethane solution to polymethyl methacrylate solution is 1:(4-5). Optionally, the volume ratio of the oil phase to the Span 20 aqueous solution is 1:(10-20); Optionally, the volume ratio of the oil phase to the Span 20 aqueous solution is 1:15.

[0011] According to some embodiments of this application, the mass concentration of poloxamer F118 dissolved in deionized water is 15%-25%.

[0012] According to a third aspect of this application, an ultrasonic coupling bag is also provided, containing the ultrasonic coupling agent described above or the ultrasonic coupling agent prepared by the above preparation method.

[0013] According to some embodiments of this application, the ultrasonic coupling agent is encapsulated in an ultrasonic coupling bag prepared by a polyolefin elastomer-TiO2 / PWA film.

[0014] According to some embodiments of this application, the preparation method of polyolefin elastomer-TiO2 / PWA film includes: Poloxamer F127 was mixed with anhydrous ethanol to obtain the first mixed solution; Adding titanium tetrachloride to the first mixed solution yields the second mixed solution; Add an aqueous solution of phosphotungstic acid to the second mixed solution to obtain a TiO2 / PWA suspension; The polyolefin elastomer-TiO2 / PWA film was prepared by impregnating the polyolefin elastomer in a TiO2 / PWA suspension using a dip-coating method. Optionally, the weight ratio of poloxamer F127 to anhydrous ethanol is 1:(25-35). Optionally, the weight ratio of the first mixed solution to titanium tetrachloride is 5:(1-1.3). Optionally, the volume ratio of the second mixed solution to the phosphotungstic acid aqueous solution is 1:(0.8-1.2).

[0015] According to some embodiments of this application, the ultrasonic coupling bag includes: a coupling agent storage unit for storing the ultrasonic coupling agent; An adjustment unit, located between the coupling agent storage unit and the probe scanning unit, is openable and closeable to control the flow of the ultrasound coupling agent; and Probe scanning unit.

[0016] According to some embodiments of this application, the adjustment unit is a concave-convex bone sealing strip; Optionally, the probe scanning unit has a groove design; Optionally, the bottom thickness of the probe scanning unit is less than the sidewall thickness. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the ultrasonic coupling bag structure in an example embodiment of this application.

[0018] Figure 2 This is a schematic diagram of the probe scanning unit of the ultrasonic coupling bag in an example embodiment of this application.

[0019] Figure 3 This is a schematic diagram of radiation test results from an example embodiment of this application. Detailed Implementation

[0020] The technical solution of this application will be clearly and completely described below with reference to the embodiments of this application. Obviously, the described embodiments are only some embodiments of this application, not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0021] It should be particularly noted that similar substitutions and modifications made to this application are obvious to those skilled in the art, and they are all considered to be included in this application. Those skilled in the art can obviously make modifications or appropriate alterations and combinations to the methods and applications described herein without departing from the content, spirit, and scope of this application to implement and apply the technology of this application. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments.

[0022] Unless otherwise specified, this application is conducted under standard conditions or conditions recommended by the manufacturer. The raw materials or excipients used, as well as the reagents or instruments used, whose manufacturers are not specified, are all conventional products that can be obtained commercially.

[0023] The following is a detailed description of this application.

[0024] This application provides an ultrasonic coupling bag, an ultrasonic coupling agent, and a method for preparing the same.

[0025] An ultrasonic coupling agent according to this application includes a first component and a second component; The first component is prepared from the following raw materials in parts by weight: 90-110 for phenylxyl ethane; 2,5-Diphenyloxazole 0.8-1.2; Polymethyl methacrylate 7-12; Dichloromethane 90-110; 202-3; Deionized water 90-110; The second component includes: Poloxamer F188 and deionized water; The mass ratio of the first component, Poloxamer F188, to deionized water is (2-3):1:(4-6). Optionally, the mass ratio of the first component: poloxamer F188: deionized water is 2.5:1:5.

[0026] In some examples, the first component is prepared from raw materials comprising the following parts by weight: 100g of phenylxylmethylethane; 2,5-Diphenyloxazole 1; Polymethyl methacrylate 9; 100g of dichloromethane; Span 202.5; 100% deionized water.

[0027] In some examples, the preparation method of the ultrasonic coupling agent includes: A 2,5-diphenyloxazole-phenylxylethane solution was prepared by adding 2,5-diphenyloxazole (PPO) dropwise to phenylxylethane. Polymethyl methacrylate (PMMA) is added to dichloromethane to prepare a PMMA solution; The 2,5-diphenyloxazole-phenylxylene ethane solution was mixed with the polymethyl methacrylate solution to form an oil phase; The oil phase was mixed with an aqueous solution of Span 20 to obtain a suspension, which was then dried to obtain a powder. The ultrasonic coupling agent is prepared by mixing and dissolving the powder with poloxamer F188 in deionized water.

[0028] Optionally, the volume ratio of the oil phase to the Span 20 aqueous solution is 1:(10-20); Optionally, the volume ratio of the oil phase to the Span 20 aqueous solution is 1:15.

[0029] Optionally, the mass concentration of poloxamer F118 dissolved in deionized water is 15%-25%.

[0030] In some examples, the preparation method of the ultrasonic coupling agent includes: A 1 wt% solution of 2,5-diphenyloxazol-phenylxylethane was prepared by adding PPO dropwise to a certain mass of phenylxylethane. Polymethyl methacrylate was added to dichloromethane to prepare a polymethyl methacrylate solution with a concentration of 9 wt%. A 2,5-diphenyloxazolium-phenylxylene ethane solution and a polymethyl methacrylate solution were mixed at a volume ratio of 1:(4-5) and stirred at 10,000 rpm for 5 min to form the oil phase. Span 20 was added to a certain mass of deionized water to prepare a 2.5 wt% Span 20 aqueous solution. 20 g of oil phase was added dropwise to 300 g of Span 20 aqueous solution, and homogenized at 10,000 rpm for 15 min. The homogenized emulsion was sonicated for 50 min, magnetically stirred at 300 rpm, heated at 35 ℃ for 6 h, centrifuged at 8,000 rpm for 10 min, the special luminescent material was retained and washed with deionized water, and dried in an oven at 40 ℃ to obtain luminescent material powder.

[0031] Weigh a grams of poloxamer F188; weigh b grams of deionized water (b=5a); weigh 2.5a grams of luminescent material powder; mix them and stir at a temperature of 1-8℃ until the white powder is completely dissolved and becomes transparent to complete the material preparation.

[0032] The ultrasound coupling agent of this application is liquid when it is not in contact with the human body. When it is placed on the human body surface, the coupling agent solidifies into a hydrogel due to body temperature. When it is in contact with a patient who has undergone radiological implantation or has been injected with radiopharmaceuticals, it can provide a luminescent indication. After use, the temperature is lowered to make the hydrogel turn back into a liquid.

[0033] The ultrasonic coupling bag of this application contains the aforementioned ultrasonic coupling agent; optionally, the ultrasonic coupling agent is encapsulated in an ultrasonic coupling bag made of a polyolefin elastomer-TiO2 / PWA film.

[0034] In some examples, the preparation method of the polyolefin elastomer-TiO2 / PWA film of this application includes: Poloxamer F127 was mixed with anhydrous ethanol to obtain the first mixed solution; Adding titanium tetrachloride to the first mixed solution yields the second mixed solution; Add an aqueous solution of phosphotungstic acid to the second mixed solution to obtain a TiO2 / PWA suspension; Polyolefin elastomer-TiO2 / PWA film was prepared by impregnating a TiO2 / PWA suspension with a dip-coating method.

[0035] Optionally, the weight ratio of poloxamer F127 to anhydrous ethanol is 1:(25-35). Optionally, the weight ratio of the first mixed solution to titanium tetrachloride is 5:(1-1.3). Optionally, the volume ratio of the second mixed solution to the phosphotungstic acid aqueous solution is 1:(0.8-1.2).

[0036] Optionally, the aqueous solution of phosphotungstic acid can be prepared by dissolving approximately 2 times its weight of phosphotungstic acid in 1 times its weight of deionized water to obtain an aqueous solution of approximately 67 wt%.

[0037] In some instances, the ultrasonic coupling bag of this application includes: a coupling agent storage unit for storing the ultrasonic coupling agent; An adjustment unit, located between the coupling agent storage unit and the probe scanning unit, is openable and closeable to control the flow of the ultrasonic coupling agent; and Probe scanning unit.

[0038] Optionally, the adjustment unit is a concave-convex bone sealing strip.

[0039] In some examples, during use, the ultrasound coupling bag of this application is removed from a refrigerator at 4-10 °C, the concave-convex bone sealing structure is left open, and a certain amount of coupling agent is squeezed from the coupling agent storage unit into the probe scanning unit as needed; the concave-convex bone sealing structure is then closed by pressing, sealing the coupling agent into the probe scanning unit; the probe scanning unit is placed on the skin to be examined, and the coupling agent solidifies into a gel through the heat of the skin, and the condition of the coupling agent is observed. If the patient has undergone radiopharmaceutical injection or radiopharmaceutical implantation, the coupling agent or gel will emit a blue-green glow. After the coupling agent solidifies, an ultrasound examination is performed. After the examination, the concave-convex bone sealing structure is opened, all the coupling agent in the coupling agent storage unit is poured into the probe scanning unit, and the unit is placed in a refrigerator to return to a liquid state.

[0040] In some examples, during use, a portion of the coupling agent is squeezed from the storage section into the probe scanning unit through the adjustment unit (concave-convex bone sealing strip), and then the concave-convex bone sealing strip is pressed to seal the coupling agent in the probe scanning unit, without returning it to the coupling agent storage unit, which has a larger volume than the probe scanning unit.

[0041] In some examples, the coupling agent storage unit is made of rubber material with a certain volume change capability, and optionally, it is made of silicone rubber; optionally, the thickness does not exceed 0.1 mm.

[0042] Optionally, the probe scanning unit adopts a groove design, with a thin polyolefin elastomer film (<0.2mm) at the bottom and a thicker polyolefin elastomer film (>0.5mm) around the perimeter, so that the bottom can fit the skin well when placed on the skin.

[0043] In some examples, the preparation method of the polyolefin elastomer-TiO2 / PWA (phosphotungstic acid) film of this application includes: 0.67 g of surfactant poloxamer F127 and 18.43 mL of anhydrous ethanol were heated and stirred at 45 °C for 30 min until colorless and transparent; after returning to room temperature, 1.93 mL of titanium tetrachloride was added and stirred for 1 h to obtain a light yellow solution; finally, 2.2 mL of ultrapure water was added dropwise, stirred, and allowed to stand to obtain the TiO2 precursor solution. Dissolve 1.8 g of phosphotungstic acid in 1 mL of deionized water, then add 1 mL of TiO2 precursor solution. Mix the solution evenly by sonication and shaking to obtain a white suspension. Wash the suspension three times with deionized water and disperse the product in deionized water to obtain a TiO2 / PWA solution. A beaker containing TiO2 / PWA solution was placed on an iron stand, and a polyolefin elastomer substrate was placed on a fixture at the same horizontal level as the beaker. After the substrate was evenly coated with the solution, it was left to remain for 8 seconds. After removing it from the liquid surface, the polyolefin elastomer substrate with wet solution was hung on the fixture for 2 minutes, allowing the liquid to drip off naturally. Finally, it was removed and laid flat. The material was placed flat in a constant temperature and humidity chamber at a temperature of 26 °C and a relative humidity of 80% for 2 hours to obtain a polyolefin elastomer-TiO2 / PWA (phosphotungstic acid) film.

[0044] The ultrasonic coupling bag of this application contains tungsten metal, which has a strong absorption effect on radioactivity. Through the strong absorption of gamma rays, more energy is converted into electron energy, thereby making the color-changing material more sensitive to radiation.

[0045] In some examples, such as Figure 3 As shown, this application uses radiation rays and ultraviolet light generated by the luminescent material in the coupling agent to induce discoloration of TiO2 / PWA composite material. The degree of discoloration caused by a dose of 20 mGy is used as the colorimetric pattern. When the discoloration of the material makes the colorimetric pattern completely indistinguishable, it is considered that the corresponding dose has been reached.

[0046] The above description of the embodiments is only for the purpose of helping to understand the method and core ideas of this application. It should be noted that, for those skilled in the art, several improvements and modifications can be made to this application without departing from the principles of this application, and these improvements and modifications also fall within the protection scope of the claims of this application.

Claims

1. An ultrasonic coupling agent, characterized in that, The ultrasonic coupling agent comprises a first component and a second component; The first component is prepared from raw materials comprising the following parts by weight: 90-110 for phenylxyl ethane; 2,5-Diphenyloxazole 0.8-1.2; Polymethyl methacrylate 7-12; Dichloromethane 90-110; 202-3; Deionized water 90-110; The second component comprises: poloxamer F188 and deionized water; The mass ratio of the first component, poloxamer F188, to deionized water is (2-3):1:(4-6).

2. The ultrasonic coupling agent according to claim 1, characterized in that, The first component is prepared from raw materials comprising the following parts by weight: 100g of phenylxylmethylethane; 2,5-Diphenyloxazole 1; Polymethyl methacrylate 9; 100g of dichloromethane; Span 202.5; 100% deionized water; Optionally, the mass ratio of the first component: poloxamer F188: deionized water is 2.5:1:

5.

3. A method for preparing the ultrasonic coupling agent according to claim 1 or 2, characterized in that, include: A 2,5-diphenyloxazole-phenylxylethane solution was prepared by adding 2,5-diphenyloxazole to phenylxylethane. Polymethyl methacrylate (PMMA) is added to dichloromethane to prepare a PMMA solution; The 2,5-diphenyloxazole-phenylxylene ethane solution was mixed with the polymethyl methacrylate solution to form an oil phase; The oil phase was mixed with an aqueous solution of Span 20 to obtain a suspension, which was then dried to obtain a powder. The ultrasonic coupling agent is prepared by mixing and dissolving the powder with poloxamer F188 in deionized water.

4. The method for preparing the ultrasonic coupling agent according to claim 3, characterized in that, The volume ratio of the 2,5-diphenyloxazole-phenylxylylethane solution to the polymethyl methacrylate solution is 1:(4-5). Optionally, the volume ratio of the oil phase to the Span 20 aqueous solution is 1:(10-20); Optionally, the volume ratio of the oil phase to the Span 20 aqueous solution is 1:

15.

5. The method for preparing the ultrasonic coupling agent according to claim 3, characterized in that, The mass concentration of poloxamer F118 dissolved in the deionized water is 15%-25%.

6. An ultrasonic coupling bag, characterized in that, It contains the ultrasonic coupling agent as described in claim 1 or 2, or the ultrasonic coupling agent prepared by any of the preparation methods described in claims 3-5.

7. The ultrasonic coupling bag according to claim 6, characterized in that, The ultrasonic coupling agent is encapsulated in an ultrasonic coupling bag made of polyolefin elastomer-TiO2 / PWA film.

8. The ultrasonic coupling bag according to claim 7, characterized in that, The method for preparing the polyolefin elastomer-TiO2 / PWA film includes: Poloxamer F127 was mixed with anhydrous ethanol to obtain the first mixed solution; Add titanium tetrachloride to the first mixed solution to obtain a second mixed solution; Add an aqueous solution of phosphotungstic acid to the second mixed solution to obtain a TiO2 / PWA suspension; The polyolefin elastomer was impregnated in the TiO2 / PWA suspension using the dip-coating method to obtain the polyolefin elastomer-TiO2 / PWA film. Optionally, the weight ratio of poloxamer F127 to anhydrous ethanol is 1:(25-35). Optionally, the weight ratio of the first mixed solution to the titanium tetrachloride is 5:(1-1.3). Optionally, the volume ratio of the second mixed solution to the phosphotungstic acid aqueous solution is 1:(0.8-1.2).

9. The ultrasonic coupling bag according to claim 8, characterized in that, The ultrasonic coupling bag includes: a coupling agent storage unit for storing the ultrasonic coupling agent; An adjustment unit, located between the coupling agent storage unit and the probe scanning unit, is openable and closeable to control the flow of the ultrasonic coupling agent; and Probe scanning unit.

10. The ultrasonic coupling bag according to claim 9, characterized in that, The adjustment unit is a concave-convex bone sealing strip; Optionally, the probe scanning unit has a groove design; Optionally, the bottom thickness of the probe scanning unit is less than the sidewall thickness.

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