Lactobacillus reuteri YZ-1 and application thereof

By isolating Lactobacillus reuteri YZ-1 from the intestines of zebrafish, the problems of hepatointestinal damage, Streptococcus dysgalactiae infection, and intestinal inflammation induced by high-iron feed in aquaculture were solved, achieving improvement in hepatointestinal health and enhanced resistance to pathogens.

CN122038232AActive Publication Date: 2026-05-15OCEAN UNIV OF CHINA
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Patent Information

Application Number
CN202610319701.4
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-03-17
Publication Date
2026-05-15
Estimated Expiration
2046-03-17

AI Technical Summary

Technical Problem

There is a lack of comprehensive probiotics in the current technology that can simultaneously solve multiple health problems in aquaculture, such as liver and intestinal damage induced by high-iron feed, streptococcal infection, and bacterial enteritis. In particular, there are no clear reports on native probiotic strains derived from aquatic animals themselves.

Method used

A strain of Lactobacillus reuteri YZ-1, isolated from the intestine of zebrafish, was provided. It can inhibit Streptococcus faecium by reducing liver iron content and secreting specific metabolites, improve intestinal inflammation, and enhance resistance to pathogens. It can be applied to functional fish feed.

Benefits of technology

Lactobacillus reuteri YZ-1 significantly reduces iron content in the liver and intestines of fish, inhibits Streptococcus faecium, enhances resistance to Edwardsiella tarda, improves intestinal structure, reduces the expression of inflammatory factors, and alleviates liver and intestinal damage and intestinal inflammation caused by high-iron feed.

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Abstract

The invention belongs to the technical field of microorganisms, and particularly relates to lactobacillus reuteri YZ-1 and application thereof. The lactobacillus reuteri YZ-1 is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.34974, and the lactobacillus reuteri YZ-1 is separated from the intestinal tract of an aquatic animal zebra fish. The strain can relieve fish liver and intestine injury induced by high-iron feed and reduce the content of total iron and ferrous iron in the liver; the fermentation supernate inhibits streptococcus dysgalactiae, but thalli do not inhibit streptococcus dysgalactiae; the survival rate of the zebrafish infected by the edwardsiella tarda is improved; expression of inflammatory factors is inhibited, and intestinal inflammation is improved. The invention also provides a microbial inoculum containing the strain and a functional fish feed. The strain disclosed by the invention has the functions of relieving iron overload, resisting infection and resisting inflammation, is unique in antibacterial mode and is suitable for being applied to aquaculture.
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