New application of p-hydroxycinnamic acid

By applying p-hydroxycinnamic acid to the preventive treatment of noise-induced hearing loss, the problems of insufficient safety and poor compliance of existing drugs are solved, cochlear hair cells are protected, the risk of hearing loss is reduced, and a brand-new preventive treatment approach is provided.

CN122075458APending Publication Date: 2026-05-26SHANDONG FIRST MEDICAL UNIV & SHANDONG ACADEMY OF MEDICAL SCI
0 Cites 0 Cited by

Patent Information

Application Number
CN202610495531.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-04-15
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Existing drugs for treating noise-induced hearing loss have significant side effects and insufficient safety. Furthermore, there is a lack of specific drugs that can repair inner ear damage and reverse hearing loss. Current intervention methods cannot fully cover non-occupational exposure scenarios, have poor compliance, and cannot achieve preventive protection.

Method used

Using p-hydroxycinnamic acid as a natural small molecule compound, a drug for preventing and treating noise-induced hearing loss is prepared by reducing cellular oxidative stress. The appropriate dose is 25-100 mg/kg, which is used to preventively protect cochlear hair cells. It is administered orally and can cross the blood-labyrinth barrier to reach the inner ear target organ.

Benefits of technology

It significantly reduces noise damage to cochlear hair cells, improves patient compliance, reduces the risk of hearing loss, has few side effects, a wide range of applications, is suitable for long-term use, and has higher practical application value.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The invention provides application of p-hydroxycinnamic acid in preparation of a medicine for preventing and treating noise-induced deafness. The invention has the advantages that the p-hydroxycinnamic acid has the advantages of strong pertinence, high safety, convenience in medication, good patient compliance and the like, not only effectively overcomes the defects of the existing noise-induced hearing loss treatment medicines, but also provides a brand-new preventive treatment thought; important clinical popularization significance and industrial application prospects are realized.
Need to check novelty before this filing date? Find Prior Art