A hydrogel patch and a preparation method thereof
By optimizing the composition and structure of hydrogel patches, and using ingredients such as sodium polyacrylate and aluminum hydroxyl to form a mesh and block gel layer, the problems of short effective time and harmful preservatives in hydrogel patches have been solved, achieving a long-lasting antibacterial and safe skin patch.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- HENAN HEYI BIOTECHNOLOGY CO LTD
- Filing Date
- 2025-12-26
- Publication Date
- 2026-05-29
AI Technical Summary
Existing hydrogel patches have a short effective time, usually losing their function after 2-3 hours or 4-12 hours, and contain preservatives that may be harmful to the human body.
Using sodium polyacrylate, aluminum hydroxyl, humectants, thickeners, propylene glycol, and antibacterial agents (such as nano zinc oxide or nano silver) as the main components, a gel layer with a network and block structure is formed by controlling the proportion of components and the process, thus avoiding the use of preservatives.
The effective time of the hydrogel patch has been increased to more than 48 hours. It has antibacterial function, reduces skin irritation and inflammation risk, and reduces negative impacts on the human body.
Smart Images
Figure CN122097313A_ABST
Abstract
Description
Technical Field
[0001] This application relates to the field of hydrogel technology, specifically to a hydrogel patch and its preparation method. Background Technology
[0002] Hydrogel patches can typically be used as medical hydrogel patches or other functional hydrogel patches. Currently, medical hydrogel patches generally lose their effectiveness after 2-3 hours, while other functional hydrogel patches generally lose their corresponding functions after 4-12 hours. Summary of the Invention
[0003] In view of this, the main technical problem to be solved by this application is how to improve the effective time of hydrogel patches, and provides a hydrogel patch and its preparation method to improve the effective time of hydrogel patches.
[0004] To solve the above-mentioned technical problems, one technical solution adopted in this application is: to provide a hydrogel patch and its preparation method, comprising a gel layer, wherein the materials of the gel layer include, by mass percentage: Sodium polyacrylate, 10 to 20 parts by weight; Aluminum hydroxychloroquine, 1 part to 3 parts by weight; Moisturizer, 40 to 70 parts by weight; Tackifier, 6 to 15 parts by weight; Propylene glycol, 10 to 20 parts by weight; Antibacterial agent, 1 to 5 parts by weight; Kaolin, 1 part by weight to 3 parts by weight; The antibacterial agents include nano zinc oxide and / or nano silver.
[0005] In some embodiments, the materials of the gel layer include, by weight parts: Sodium polyacrylate, 10 to 15 parts by weight; Aluminum hydroxyacetate, 1.2 to 2 parts by weight; Moisturizer, 50-60 parts by weight; Tackifier, 8 to 12 parts by weight; Propylene glycol, 12 to 18 parts by weight; Antibacterial agent, 1 to 5 parts by weight; Kaolin, 1 to 2 parts by weight.
[0006] In some embodiments, a crosslinking regulator is also included, wherein the crosslinking regulator is present in a mass fraction of 2 to 5 parts by mass; The crosslinking regulator includes EDTA and / or citric acid; The humectant includes one or more of glycerol, butylene glycol, glyceryl polyether-26 and D-panthenol; The thickeners include gelatin and PVP.
[0007] In some embodiments, the gel layer includes a mesh structure and a block structure, with the block structure embedded in the mesh of the mesh structure.
[0008] In some implementations, multiple block structures form a strip structure, which includes an arc-shaped strip structure or an irregular strip structure.
[0009] In some implementations, the following are included: We provide nano zinc oxide sol, which includes nano zinc oxide hydrogel or nano silver hydrogel; The humectant and propylene glycol were mixed, and aluminum hydroxyl was added to obtain the first intermediate. Sodium polyacrylate and a tackifier are mixed to form a second intermediate. The second intermediate is then mixed with the first intermediate to form a third intermediate. Adding kaolin to water forms a fourth intermediate; The nano zinc oxide sol was added to the fourth intermediate, and the third intermediate was added. The mixture was stirred, degassed under vacuum, and sonicated to obtain the fifth intermediate. The fifth intermediate is coated onto a nonwoven fabric, dried to form a gel layer, and then a backing is placed on top of the gel layer.
[0010] "Providing nano zinc oxide sol" includes: Nano zinc oxide was added to pure water and ultrasonically treated to obtain nano zinc oxide sol; the mass-volume ratio (g / L) of nano zinc oxide to pure water was 1-5:100, and the ultrasonic time was 30-60 min to obtain nano zinc oxide sol.
[0011] In some embodiments, "mixing a humectant and propylene glycol, and adding aluminum hydroxyl to obtain a first intermediate; mixing sodium polyacrylate and a thickener to form a second intermediate; and mixing the second intermediate with the first intermediate to form a third intermediate" includes: Glycerol and propylene glycol were mixed at a volume ratio of 3-5:1 and stirred at a speed of 300-400 r / min for 5-10 min. EDTA and aluminum hydroxyl were added sequentially and stirred to obtain the first intermediate. The mass-volume ratio of EDTA to glycerol was (1-2) g: 100 mL, and the mass-volume ratio of aluminum hydroxyl to glycerol was (2-5) g: 100 mL. Sodium polyacrylate, gelatin, CMC-Na and PVPK90 are mixed evenly using an equal-volume incremental mixing method; the mass ratio of sodium polyacrylate, gelatin, CMC-Na and PVPK30 is (10-15):(5-10)(3-10):(3-5), forming a second intermediate; The second intermediate is added to the first intermediate and stirred at a speed of 300-400 r / min for 5-10 min. The mass-to-volume ratio of sodium polyacrylate in the second intermediate to glycerol in the first intermediate is (10-45) g: 100 mL.
[0012] In some implementations, "adding kaolin to water to form a fourth intermediate" includes: Citric acid and kaolin citric acid in a mass ratio of 4-10:10 are added to distilled water and stirred at a speed of 300-400 r / min for 5-10 min to form the fourth intermediate product.
[0013] In some embodiments, "adding nano-zinc oxide sol to a fourth intermediate, adding a third intermediate, stirring, vacuum degassing, and sonicating to obtain a fifth intermediate" includes: Add the nano zinc oxide sol to the fourth intermediate and stir at 300-400 r / min for 5-10 min; wherein the mass-volume ratio of citric acid to nano zinc oxide sol is (10-15) g: 100 mL. Add the third intermediate and stir for 15-25 minutes; the mass ratio of citric acid to aluminum hydroxide is 2-5:5.
[0014] The beneficial effects of this application are as follows: Unlike the prior art, the hydrogel patch of this application embodiment has an effective time of up to 48 hours or more, providing a longer effective period. The hydrogel patch of this application embodiment also has antibacterial properties, reducing the proliferation of anaerobic bacteria, thus reducing irritation to skin tissue and the risk of inflammation or infection. Attached Figure Description
[0015] Figure 1 This is a scanning electron microscope image of one embodiment of the hydrogel patch of this application; Figure 2 This is another scanning electron microscope image of one embodiment of the hydrogel patch of this application; Figure 3 This is a scanning electron microscope image of one embodiment of the nano zinc oxide of this application. Detailed Implementation
[0016] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of this application, and not all of them. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.
[0017] Unless otherwise defined, all technical and scientific terms used in this application have the same meaning as commonly understood by one of ordinary skill in the art to which this application pertains. The terminology used in the specification of this application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. The term "and / or" as used in this application includes any and all combinations of one or more of the associated listed items.
[0018] The following describes some embodiments of this application in detail. Unless otherwise specified, the following embodiments and features can be combined with each other.
[0019] In related technologies, hydrogel patches typically dehydrate and dry into insoluble sheets within about 4 hours after use, and at most within 10 hours, thus losing their responsive function.
[0020] To extend the shelf life of hydrogels, most hydrogel products contain preservatives to varying degrees. Commonly used preservatives include benzoic acid, sorbic acid, and sulfurous acid. Excessive intake of preservatives or high levels of impurities can cause acute or chronic poisoning. Long-term, high-dose intake of acidic substances such as benzoic acid and sorbic acid may disrupt the body's acid-base balance, leading to symptoms such as dizziness and diarrhea. Preservatives may also contain heavy metals such as lead and mercury. Excessive levels of these heavy metals can cause heavy metal poisoning. Mercury poisoning, for example, can cause abdominal pain, shock, and uremia. Some individuals may have sensitive constitutions and be allergic to certain preservative components, such as isothiazolinones, formaldehyde releasers, and parabens. Ingesting food or medications containing preservatives may cause allergic reactions such as itching and rashes. Furthermore, some preservatives, if used or ingested long-term, may pose risks of cancer or birth defects. For example, parabens may increase the risk of breast cancer, while nitrates may react with nitrites in meat products to form carcinogenic nitrosamines. Additionally, triclosan and triclocarban may harm the health of the fetus.
[0021] This application provides a hydrogel patch, including a gel layer, wherein the materials of the gel layer comprise, by weight percentage: Sodium polyacrylate, 10 to 20 parts by weight; Aluminum hydroxychloroquine, 1 part to 3 parts by weight; Moisturizer, 40 to 70 parts by weight; Tackifier, 6 to 15 parts by weight; Propylene glycol, 10 to 20 parts by weight; Antibacterial agent, 1 to 5 parts by weight; Kaolin, 1 part by weight to 3 parts by weight; The antibacterial agents include nano zinc oxide and / or nano silver.
[0022] In this embodiment, by controlling the composition of the gel layer to include the above components—sodium polyacrylate as the cross-linking backbone, aluminum hydroxyl as the cross-linking agent, kaolin as the backbone, and propylene glycol as the penetration enhancer—and by mixing these components and controlling their amounts within the aforementioned range, the components interact to form a hydrogel layer. Specifically, by adding gelatin and controlling its amount within the aforementioned range, the gelatin, with its good water absorption and swelling properties, interacts with the humectant and thickener, increasing the moisturizing time of the gel layer to 48 hours or more. In this embodiment, by adding nano-zinc oxide and / or nano-silver, the gel layer acquires antibacterial properties, reducing the proliferation of anaerobic bacteria, thus minimizing irritation to skin tissue and reducing the risk of inflammation or infection.
[0023] Sodium polyacrylate can be in quantities of 10, 13, 15, 18, or 20 parts by weight. Aluminum hydroxyl can be in quantities of 1, 2, 2.5, or 3 parts by weight. A humectant can be in quantities of 40, 45, 50, 60, 63, or 70 parts by weight. A tackifier can be in quantities of 6, 8, 10, 13, or 15 parts by weight. Propylene glycol can be in quantities of 10, 13, 15, 18, or 20 parts by weight. An antibacterial agent can be in quantities of 1, 2, 2.5, 3, or 5 parts by weight. Kaolin can be in quantities of 1, 2, 2.5, or 3 parts by weight.
[0024] In some embodiments, the materials of the gel layer include, by weight parts: Sodium polyacrylate, 10 to 15 parts by weight; Aluminum hydroxyacetate, 1.2 to 2 parts by weight; Moisturizer, 50-60 parts by weight; Tackifier, 8 to 12 parts by weight; Propylene glycol, 12 to 18 parts by weight; Antibacterial agent, 1 to 5 parts by weight; Kaolin, 1 to 2 parts by weight.
[0025] In this embodiment of the application, by controlling the mass ratio of the above-mentioned components within the above-mentioned range, the drug loading performance, effective time, and antibacterial properties of the gel layer are improved.
[0026] Sodium polyacrylate can be in quantities of 10 parts by weight, 13 parts by weight, 15 parts by weight, etc. Aluminum hydroxyl can be in quantities of 1.2 parts by weight, 1.5 parts by weight, 1.8 parts by weight, 2 parts by weight. The humectant can be in quantities of 50 parts by weight, 52 parts by weight, 55 parts by weight, 60 parts by weight, etc. The tackifier can be in quantities of 8 parts by weight, 9 parts by weight, 10 parts by weight, 12 parts by weight, etc. Propylene glycol can be in quantities of 12 parts by weight, 13 parts by weight, 15 parts by weight, 16 parts by weight, 18 parts by weight, etc. The antibacterial agent can be in quantities of 1 part by weight, 2 parts by weight, 2.5 parts by weight, 3 parts by weight, 5 parts by weight, etc. Kaolin can be in quantities of 1 part by weight, 1.3 parts by weight, 1.5 parts by weight, 2 parts by weight, etc.
[0027] In some embodiments, the gel layer material further includes a crosslinking regulator, wherein the crosslinking regulator is present in parts by mass of 2 to 5. In the embodiments of this application, the addition of a crosslinking regulator to the adhesive facilitates the crosslinking reaction of polyacrylic acid and aluminum hydroxyl group to form a gel layer. The crosslinking regulator can be present in parts by mass of 2, 2.5, 3, or 5, etc.
[0028] In some embodiments, crosslinking regulators include EDTA and citric acid; humectants include glycerol, butylene glycol, glyceryl polyether-26, and D-panthenol; and thickeners include gelatin and PVP (polyvinylpyrrolidone). In the embodiments of this application, the above-mentioned crosslinking regulators, humectants, and thickeners can effectively coordinate with other components of the gel layer. In the embodiments of this application, PVP can be PVPk90 (polyvinylpyrrolidone with a K value of 90).
[0029] In this embodiment, the gel layer does not contain preservatives, which reduces negative impacts on the human body. The gel layer in this embodiment has good drug-carrying capacity and can carry drugs such as all topical medications, as well as traditional Chinese medicine and Western medicine suitable for transdermal absorption.
[0030] In some implementations, such as Figure 1 and Figure 2 As shown, the gel layer includes a network structure and a block structure, with the block structure embedded within the mesh of the network structure. In this application example, the gel layer, as can be seen from its microstructure, includes both a network structure and a block structure, resulting in greater stability of the gel layer.
[0031] In some embodiments, multiple block structures form a strip structure, which includes arc-shaped strip structures or irregular strip structures. In the embodiments of this application, multiple block structures form an irregular strip structure, so that the gel layer has multiple strip structures, which has a certain degree of air permeability and strong structural stability.
[0032] In this embodiment, the thickness of the gel layer is 1-2 mm.
[0033] In this embodiment, the hydrogel patch further includes a nonwoven fabric and a backing, which are respectively disposed on both sides of the gel layer.
[0034] In some embodiments, the method for preparing the hydrogel includes: We provide nano zinc oxide sol, which includes nano zinc oxide hydrogel or nano silver hydrogel; The humectant and propylene glycol were mixed, and aluminum hydroxyl was added to obtain the first intermediate. Sodium polyacrylate and a tackifier are mixed to form a second intermediate. The second intermediate is then mixed with the first intermediate to form a third intermediate. Adding kaolin to water forms a fourth intermediate; The nano zinc oxide sol was added to the fourth intermediate, and the third intermediate was added. The mixture was stirred, degassed under vacuum, and sonicated to obtain the fifth intermediate. The fifth intermediate is coated onto a nonwoven fabric, dried to form a gel layer, and then a backing is placed on top of the gel layer.
[0035] In this embodiment, the gel layer prepared by the above method can effectively react to generate a gel layer with a microscopic network structure and block structure, so that the gel layer in this embodiment has a longer effective time and better antibacterial properties.
[0036] In some embodiments, the method for preparing the hydrogel includes: Nano zinc oxide was added to pure water and ultrasonically treated to obtain nano zinc oxide sol; the mass-volume ratio (g / L) of nano zinc oxide to pure water was 1-5:100, and the ultrasonic time was 30-60 min to obtain nano zinc oxide sol.
[0037] Glycerol and propylene glycol were mixed at a volume ratio of 3-5:1 and stirred at a speed of 300-400 r / min for 5-10 min. EDTA (ethylenediaminetetraacetic acid) and aluminum hydroxyl were added sequentially and stirred to obtain the first intermediate. The mass-volume ratio of EDTA to glycerol was (1-2) g: 100 mL, and the mass-volume ratio of aluminum hydroxyl to glycerol was (2-5) g: 100 mL.
[0038] Sodium polyacrylate, gelatin, CMC-Na and PVPK90 are mixed evenly by an equal-volume incremental mixing method; the mass ratio of sodium polyacrylate, gelatin, CMC-Na (sodium carboxymethyl cellulose) and PVPK30 is (10-15):(5-10)(3-10):(3-5), forming a second intermediate.
[0039] The second intermediate is added to the first intermediate and stirred at a speed of 300-400 r / min for 5-10 min. The mass-to-volume ratio of sodium polyacrylate in the second intermediate to glycerol in the first intermediate is (10-45) g: 100 mL.
[0040] Citric acid and kaolin citric acid in a mass ratio of 4-10:10 are added to distilled water and stirred at a speed of 300-400 r / min for 5-10 min to form the fourth intermediate product.
[0041] Add the nano-zinc oxide sol to the fourth intermediate, stirring at 300-400 r / min for 5-10 min; the mass-to-volume ratio of citric acid to nano-zinc oxide sol is (10-15) g:100 mL; then add the third intermediate and stir for 15-25 min; the mass ratio of citric acid to aluminum hydroxyl is 2-5:5. Stir, degas under vacuum, and sonicate to obtain the fifth intermediate.
[0042] The fifth intermediate is coated onto a nonwoven fabric, dried to form a gel layer, and then a backing is placed on top of the gel layer.
[0043] In this embodiment, by controlling the order and proportion of raw material addition within the above-mentioned range, and by controlling the stirring speed and stirring time, the resulting gel layer has a high effective working time.
[0044] For ease of understanding, the following specific embodiments are provided. Example 1
[0045] Nano zinc oxide was added to pure water and ultrasonically treated to obtain nano zinc oxide sol. The mass-volume ratio (g / L) of nano zinc oxide to pure water was 1 g: 100 mL, and the ultrasonic time was 30 min to obtain nano zinc oxide sol.
[0046] Glycerol and propylene glycol were mixed at a volume ratio of 3:1 and stirred at a speed of 300 r / min for 5 min. EDTA and aluminum hydroxyl were added sequentially and stirred to obtain the first intermediate. The mass-volume ratio of EDTA to glycerol was 2 g: 100 mL, and the mass-volume ratio of aluminum hydroxyl to glycerol was 5 g: 100 mL.
[0047] Sodium polyacrylate, gelatin, CMC-Na, and PVPK90 were mixed evenly using an equal-volume incremental mixing method; the mass ratio of sodium polyacrylate, gelatin, CMC-Na, and PVPK30 was 10:6:3:3, forming a second intermediate.
[0048] The second intermediate was added to the first intermediate and stirred at a speed of 300 r / min for 5 min. The mass-to-volume ratio of sodium polyacrylate in the second intermediate to glycerol in the first intermediate was 20 g: 100 mL.
[0049] Citric acid and kaolin citric acid in a mass ratio of 4:10 were added to distilled water and stirred at a speed of 300 r / min for 5 min to form the fourth intermediate product.
[0050] The nano-zinc oxide sol was added to the fourth intermediate, and the mixture was stirred at 300 rpm for 5 minutes; the mass-to-volume ratio of citric acid to nano-zinc oxide sol was 10 g:100 mL. The third intermediate was then added, and the mixture was stirred for 15 minutes; the mass ratio of citric acid to aluminum hydroxyl was 2:5. The mixture was stirred, degassed under vacuum, and sonicated to obtain the fifth intermediate.
[0051] The fifth intermediate is coated onto a nonwoven fabric, dried to form a gel layer, and then a backing is placed on top of the gel layer.
[0052] In this embodiment, by controlling the order and proportion of raw material addition within the above-mentioned range, and by controlling the stirring speed and stirring time, the resulting gel layer has a high effective working time.
[0053] In this embodiment of the application, the obtained hydrogel patch is characterized by comprising a gel layer, wherein the materials of the gel layer comprise, by weight percentage: sodium polyacrylate, 20 parts by weight; aluminum hydroxyl, 4 parts by weight; humectant, 100 parts by weight; tackifier, 12 parts by weight; propylene glycol, 20 parts by weight; antibacterial agent, 2 parts by weight; kaolin, 1.6 parts by weight; and crosslinking regulator, 3.6 parts by weight.
[0054] like Figure 1 and Figure 2 The image shown is a scanning electron microscope (SEM) image of the gel layer according to an embodiment of this application. It can be seen from the image that the gel layer includes a network structure and a block structure, with the block structure embedded within the mesh of the network structure. In this embodiment, the gel layer, from a microscopic perspective, includes both a network structure and a block structure, resulting in greater stability of the gel layer. Figure 3 The image shown is a scanning electron microscope image of nano-zinc oxide according to an embodiment of this application. Figure 3 It can be seen that the particle size of zinc oxide particles is around 5nm-10nm, which means that zinc oxide particles are at the nanoscale.
[0055] When the hydrogel patch of this embodiment is applied to the human body, it is observed that the hydrogel patch remains effective after 48 hours; no redness or swelling is observed on the skin.
[0056] Example 2 Unlike Example 1, the amount of nano zinc oxide added was changed, and the mass-volume ratio (g / L) of nano zinc oxide to pure water was 5g:100L. Everything else was the same as in Example 1, and will not be repeated here.
[0057] Example 3 The difference from Example 1 is that nano zinc oxide is replaced with nano silver. Otherwise, it is the same as Example 1 and will not be repeated here.
[0058] Example 4 Unlike Example 1, the specific amounts of the ingredients were adjusted as follows: Nano zinc oxide was added to pure water and ultrasonically treated to obtain nano zinc oxide sol. The mass-volume ratio (g / L) of nano zinc oxide to pure water was 1 g: 100 mL, and the ultrasonic time was 30 min to obtain nano zinc oxide sol.
[0059] Glycerol and propylene glycol were mixed at a volume ratio of 5:1 and stirred at a speed of 300 r / min for 5 min. EDTA and aluminum hydroxyl were added sequentially and stirred to obtain the first intermediate. The mass-volume ratio of EDTA to glycerol was 2 g: 100 mL, and the mass-volume ratio of aluminum hydroxyl to glycerol was 5 g: 100 mL.
[0060] Sodium polyacrylate, gelatin, CMC-Na, and PVPK90 were mixed evenly using an equal-volume incremental mixing method; the mass ratio of sodium polyacrylate, gelatin, CMC-Na, and PVPK30 was 15:10:3:5, forming a second intermediate.
[0061] The second intermediate was added to the first intermediate and stirred at a speed of 300 r / min for 5 min. The mass-to-volume ratio of sodium polyacrylate in the second intermediate to glycerol in the first intermediate was 15 g: 100 mL.
[0062] Citric acid and kaolin in a mass ratio of 10:1 were added to distilled water and stirred at a speed of 300 r / min for 5 min to form the fourth intermediate product.
[0063] Nano-zinc oxide sol was added to the fourth intermediate, and the mixture was stirred at 300 rpm for 5 minutes; the mass-to-volume ratio of citric acid to nano-zinc oxide sol was 15 g:100 mL. The third intermediate was then added, and the mixture was stirred for 15 minutes; the mass ratio of citric acid to aluminum hydroxyl was 2:5. The mixture was stirred, degassed under vacuum, and sonicated to obtain the fifth intermediate.
[0064] The fifth intermediate is coated onto a nonwoven fabric, dried to form a gel layer, and then a backing is placed on top of the gel layer.
[0065] In this embodiment of the application, the obtained hydrogel patch is characterized by comprising a gel layer, wherein the materials of the gel layer comprise, by weight percentage: sodium polyacrylate, 15 parts by weight; aluminum hydroxyl, 5 parts by weight; humectant, 100 parts by weight; tackifier, 15 parts by weight; propylene glycol, 20 parts by weight; antibacterial agent, 1 part by weight; kaolin, 0.2 parts by weight; and crosslinking regulator, 4 parts by weight.
[0066] When the hydrogel patch of this embodiment is applied to the human body, it is observed that the hydrogel patch remains effective after 48 hours.
[0067] Example 5 Unlike Example 1, the specific amounts of the ingredients were adjusted as follows: Nano zinc oxide was added to purified water and ultrasonically treated to obtain nano zinc oxide sol. The mass-volume ratio (g / L) of nano zinc oxide to purified water was 1 g: 100 mL, and the ultrasonic time was 30 min to obtain nano zinc oxide sol.
[0068] Glycerol and propylene glycol were mixed at a volume ratio of 4:1 and stirred at a speed of 300 r / min for 5 min. EDTA and aluminum hydroxyl were added sequentially and stirred to obtain the first intermediate. The mass-volume ratio of EDTA to glycerol was 1.5 g: 100 mL, and the mass-volume ratio of aluminum hydroxyl to glycerol was 3 g: 100 mL.
[0069] Sodium polyacrylate, gelatin, CMC-Na, and PVPK90 were mixed evenly using an equal-volume incremental mixing method; the mass ratio of sodium polyacrylate, gelatin, CMC-Na, and PVPK30 was 12:8:7:4, forming a second intermediate.
[0070] The second intermediate was added to the first intermediate and stirred at a speed of 300 r / min for 5 min. The mass-to-volume ratio of sodium polyacrylate in the second intermediate to glycerol in the first intermediate was 13 g: 100 mL.
[0071] Citric acid and kaolin in a mass ratio of 7:1 were added to distilled water and stirred at a speed of 300 r / min for 5 min to form the fourth intermediate product.
[0072] The nano-zinc oxide sol was added to the fourth intermediate, and the mixture was stirred at 300 rpm for 5 minutes; the mass-to-volume ratio of citric acid to nano-zinc oxide sol was 13 g:100 mL. The third intermediate was then added, and the mixture was stirred for 15 minutes; the mass ratio of citric acid to aluminum hydroxyl was 2:5. The mixture was stirred, degassed under vacuum, and sonicated to obtain the fifth intermediate.
[0073] The fifth intermediate is coated onto a nonwoven fabric, dried to form a gel layer, and then a backing is placed on top of the gel layer.
[0074] In this embodiment of the application, the obtained hydrogel patch is characterized by comprising a gel layer, wherein the materials of the gel layer comprise, by weight percentage: sodium polyacrylate, 13 parts by weight; aluminum hydroxyl, 3 parts by weight; humectant, 100 parts by weight; tackifier, 13 parts by weight; propylene glycol, 25 parts by weight; antibacterial agent, 1 part by weight; kaolin, 0.3 parts by weight; and crosslinking regulator, 3.5 parts by weight.
[0075] When the hydrogel patch of this embodiment is applied to the human body, it is observed that the hydrogel patch remains effective after 48 hours.
[0076] Example 6 The difference from Example 1 lies in the change of process parameters, as follows: Nano zinc oxide was added to purified water and ultrasonically treated to obtain nano zinc oxide sol. The mass-volume ratio (g / L) of nano zinc oxide to purified water was 1 g: 100 mL, and the ultrasonic time was 60 min to obtain nano zinc oxide sol.
[0077] Glycerol and propylene glycol were mixed at a volume ratio of 3:1 and stirred at a speed of 400 r / min for 10 min. EDTA and aluminum hydroxyl were added sequentially and stirred to obtain the first intermediate. The mass-volume ratio of EDTA to glycerol was 1 g: 100 mL, and the mass-volume ratio of aluminum hydroxyl to glycerol was 2 g: 100 mL.
[0078] Sodium polyacrylate, gelatin, CMC-Na, and PVPK90 were mixed evenly using an equal-volume incremental mixing method; the mass ratio of sodium polyacrylate, gelatin, CMC-Na, and PVPK30 was 10:6:3:3, forming a second intermediate.
[0079] The second intermediate was added to the first intermediate and stirred at a speed of 400 r / min for 10 min. The mass-to-volume ratio of sodium polyacrylate in the second intermediate to glycerol in the first intermediate was 10 g: 100 mL.
[0080] Citric acid and kaolin in a mass ratio of 4:1 were added to distilled water and stirred at a speed of 400 r / min for 10 min to form the fourth intermediate product.
[0081] The nano-zinc oxide sol was added to the fourth intermediate, and the mixture was stirred at 400 rpm for 10 min; the mass-to-volume ratio of citric acid to nano-zinc oxide sol was 10 g:100 mL. The third intermediate was then added, and the mixture was stirred for 20 min; the mass ratio of citric acid to aluminum hydroxyl was 2:5. The mixture was stirred, degassed under vacuum, and sonicated to obtain the fifth intermediate.
[0082] The fifth intermediate is coated onto a nonwoven fabric, dried to form a gel layer, and then a backing is placed on top of the gel layer.
[0083] In this embodiment, by controlling the order and proportion of raw material addition within the above-mentioned range, and by controlling the stirring speed and stirring time, the resulting gel layer has a high effective working time.
[0084] In this embodiment of the application, the obtained hydrogel patch is characterized by comprising a gel layer, wherein the materials of the gel layer comprise, by weight percentage: sodium polyacrylate, 10 parts by weight; aluminum hydroxyl, 2 parts by weight; humectant, 100 parts by weight; tackifier, 9 parts by weight; propylene glycol, 33 parts by weight; antibacterial agent, 1 part by weight; kaolin, 0.8 parts by weight; and crosslinking regulator, 4.2 parts by weight.
[0085] When the hydrogel patch of this embodiment is applied to the human body, it is observed that the hydrogel patch remains effective after 48 hours.
[0086] The above are merely embodiments of this application and do not limit the patent scope of this application. Any equivalent structural or procedural transformations made using the content of this application's specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this application.
Claims
1. A hydrogel patch, characterized by, The gel layer includes the following materials in parts by mass: Sodium polyacrylate, 10 to 20 parts by weight; Aluminum hydroxychloroquine, 1 part to 3 parts by weight; Moisturizer, 40 to 70 parts by weight; Tackifier, 6 to 15 parts by weight; Propylene glycol, 10 to 20 parts by weight; Antibacterial agent, 1 to 5 parts by weight; Kaolin, 1 part by weight to 3 parts by weight; The antibacterial agent includes nano zinc oxide and / or nano silver.
2. The hydrogel patch of claim 1, wherein, The materials of the gel layer, by mass percentage, include: Sodium polyacrylate, 10 to 15 parts by weight; Aluminum hydroxychloroquine, 1.2 to 2 parts by weight; Moisturizer, 50-60 parts by weight; Tackifier, 8 to 12 parts by weight; Propylene glycol, 12 to 18 parts by weight; Antibacterial agent, 1 to 5 parts by weight; Kaolin, 1 to 2 parts by weight.
3. The hydrogel patch of claim 1, wherein, It also includes a crosslinking regulator, wherein the crosslinking regulator is present in a mass fraction of 2 to 5 parts by mass; The crosslinking regulator includes EDTA and / or citric acid; The humectant includes one or more of glycerol, butylene glycol, glyceryl polyether-26 and D-panthenol; The thickeners include gelatin and PVP.
4. The hydrogel patch of claim 1, wherein, The gel layer includes a mesh structure and a block structure, with the block structure embedded in the mesh of the mesh structure.
5. The hydrogel patch according to claim 4, characterized in that, The multiple block structures form a strip structure, which includes an arc-shaped strip structure or an irregular strip structure.
6. A method for manufacturing a hydrogel patch, characterized in that, include: A nano zinc oxide sol is provided, wherein the nano zinc oxide sol comprises a nano zinc oxide hydrogel or a nano silver hydrogel; The humectant and propylene glycol were mixed, and aluminum hydroxyl was added to obtain the first intermediate. Sodium polyacrylate and a tackifier are mixed to form a second intermediate, and the second intermediate is mixed with the first intermediate to form a third intermediate; Adding kaolin to water forms a fourth intermediate; The nano zinc oxide sol was added to the fourth intermediate, and the third intermediate was added. The mixture was stirred and degassed under vacuum to obtain the fifth intermediate. The fifth intermediate is coated onto a nonwoven fabric, dried to form a gel layer, and then a backing is placed on the gel layer.
7. The method for manufacturing a hydrogel patch according to claim 6, characterized in that, The "providing of nano zinc oxide sol" includes: Nano zinc oxide was added to pure water and ultrasonically treated to obtain nano zinc oxide sol; the mass-volume ratio of nano zinc oxide to pure water was (1-5) g: 100 ml, and the ultrasonic time was 30-60 min to obtain nano zinc oxide sol.
8. The method for manufacturing a hydrogel patch according to claim 7, characterized in that, The process involves mixing a humectant and propylene glycol, and then adding aluminum hydroxide to obtain a first intermediate. The process of mixing sodium polyacrylate and a tackifier to form a second intermediate, and then mixing the second intermediate with the first intermediate to form a third intermediate, comprises: Glycerol and propylene glycol were mixed at a volume ratio of 3-5:1 and stirred at a speed of 300-400 r / min for 5-10 min. EDTA and aluminum hydroxyl were added sequentially and stirred to obtain the first intermediate. The mass-volume ratio of EDTA to glycerol was (1-2) g: 100 mL, and the mass-volume ratio of aluminum hydroxyl to glycerol was (2-5) g: 100 mL. Sodium polyacrylate, gelatin, CMC-Na and PVPK90 are mixed evenly using an equal-volume incremental mixing method; the mass ratio of sodium polyacrylate, gelatin, CMC-Na and PVPK90 is (10-15):(5-10)(3-10):(3-5), forming a second intermediate; The second intermediate is added to the first intermediate and stirred at a speed of 300-400 r / min for 5-10 min. The mass-to-volume ratio of sodium polyacrylate in the second intermediate to glycerol in the first intermediate is (10-45) g: 100 mL.
9. The method for manufacturing a hydrogel patch according to claim 8, characterized in that, The phrase "adding kaolin to water to form a fourth intermediate" includes: Citric acid and kaolin citric acid in a mass ratio of 4-10:10 are added to distilled water and stirred at a speed of 300-400 r / min for 5-10 min to form the fourth intermediate product.
10. The method for manufacturing a hydrogel patch according to claim 6 or 9, characterized in that, The step of "adding the nano zinc oxide sol to the fourth intermediate, adding the third intermediate, stirring, vacuum degassing, and sonicating to obtain the fifth intermediate" includes: Add the nano zinc oxide sol to the fourth intermediate and stir at 300-400 r / min for 5-10 min; wherein the mass-volume ratio of citric acid to nano zinc oxide sol is (10-15) g: 100 mL. Add the third intermediate and stir for 15-25 minutes; the mass ratio of citric acid to aluminum hydroxide is 2-5:5.