Probiotic formula suitable for plateau population and preparation method

By combining Lactobacillus plantarum, Bifidobacterium, Lactobacillus acidophilus, Lactobacillus rhamnosus, and Bacillus coagulans, a probiotic preparation suitable for people living in high-altitude areas was prepared. This solved the problem of poor systemic immune regulation in existing technologies and achieved the improvement of systemic immune regulation and intestinal barrier function.

CN122104467APending Publication Date: 2026-05-29HOSPITAL OF CHENGDU OFFICE OF PEOPLES GOVERNMENT OF TIBETAN AUTONOMOUS REGION (HOSPITAL C T)
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Patent Information

Application Number
CN202610245333.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-03-02
Publication Date
2026-05-29

AI Technical Summary

Technical Problem

Existing probiotic formulations, such as Culturelle, mainly use Lactobacillus rhamnosus LGG as the core strain. Although they can play a role in local immune regulation, they are not very effective in systemic immune regulation, especially in meeting the adaptation and immune regulation needs of people living in high-altitude areas.

Method used

A probiotic preparation suitable for people living in high-altitude areas was prepared by using a combination of Lactobacillus plantarum, Bifidobacterium, Lactobacillus acidophilus, Lactobacillus rhamnosus and Bacillus coagulans, and by anaerobic and aerobic culture, fermentation and freeze-drying. The activation of T cells and B cells by Lactobacillus rhamnosus and Bifidobacterium enhances the systemic immune regulation effect.

Benefits of technology

While suppressing excessive inflammatory responses, it enhances the neutralizing ability of B cells against pathogens, ensures systemic immune regulation, improves the growth efficiency and activity rate of the bacterial strain, strengthens the intestinal barrier function, and reduces the possibility of pathogen invasion.

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Abstract

The invention relates to the technical field of probiotic preparation, in particular to a probiotic formula suitable for plateau crowds and a preparation method, and the formula comprises the following components in parts by weight: 3-5 parts of lactobacillus plantarum, 2-4 parts of bifidobacterium, 1.5-3 parts of lactobacillus acidophilus, 1-2.5 parts of lactobacillus rhamnosus and 0.5-1.5 parts of bacillus coagulans. The method comprises the following steps: step 1, strain activation and propagation; step 2, strain fermentation; 3, thalli are collected; and step 4, strain treatment and packaging. Double barriers are formed through the lactobacillus plantarum and the lactobacillus rhamnosus, the risk of intestinal infection of a user can be reduced, meanwhile, by adding the bacillus coagulans into the formula, a growth environment is provided for other strains, and the stability of the formula is further ensured.
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