A high-efficiency screening method for risk substances in animal-derived food

CN122109414APending Publication Date: 2026-05-29DALIAN INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DALIAN INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES
Filing Date
2024-11-28
Publication Date
2026-05-29

AI Technical Summary

Technical Problem

Existing technologies for screening risk substances in animal-derived foods suffer from problems such as interference from endogenous food components and experimental background information affecting screening efficiency and accuracy.

Method used

Using ultra-high performance liquid chromatography-high resolution mass spectrometry combined with open-source global network optimization tools and interquartile range method, we filtered out endogenous components and background interference in food, and performed structural annotation and qualitative analysis of hazardous substances through database search.

Benefits of technology

It improved the efficiency and accuracy of screening for risky substances, reduced the false positive rate, and achieved efficient identification and accurate screening of unknown risky substances.

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Abstract

The present application relates to a kind of high-efficiency screening methods for risk substances in animal-derived food, comprising the following steps: 1) after the pretreatment of the animal-derived food sample to be tested, non-target detection and analysis are carried out using chromatography-mass spectrometry platform, and original chromatography-mass spectrometry data are obtained;2) by global network optimization, filter food endogenous components, while using quartile range method to remove various background interference, extract suspicious risk substances;Suspected risk substances that meet the conditions of global network optimization and quartile range method filtering at the same time are retained;3) by database search and standard comparison, the structure of suspicious risk substances is annotated and qualified.The present application effectively removes the interference of food endogenous components on risk substance screening, improves the efficiency of non-target screening.On the other hand, it has significant advantages in the screening analysis and efficient locking of unknown risk substances in animal-derived food.The present application has the advantages of high screening accuracy and low false positive rate.
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